Cu, Ag, Au Patents (Class 436/80)
  • Patent number: 10365222
    Abstract: Object: To provide a biochip for use in exhaustive analysis of a particular protein including DNA (deoxyribose nucleic acid) in a body fluid through Raman quantitative analysis.
    Type: Grant
    Filed: May 8, 2014
    Date of Patent: July 30, 2019
    Assignee: MYTECH CO., LTD.
    Inventors: Yuki Hasegawa, Katsuyuki Hasegawa
  • Patent number: 10118169
    Abstract: Metal-organic framework (MOFs) compositions based on chiral phosphine-, chiral oxazoline-, chiral pyridine-, and chiral diene-derived organic bridging ligands were synthesized and then post-synthetically metalated with metal precursors such as Ru and Rh complexes. The metal complexes could also be directly incorporated into the MOFs. The MOFs provide a versatile family of recyclable and reusable single-site solid catalysts for catalyzing a variety of asymmetric organic transformations, including the addition of arylboronic acids to ?,?-unsaturated ketones and alkimines, the hydrogenation of substituted alkene and carbonyl compounds, and cyclization reactions. The solid catalysts can also be integrated into a flow reactor or a supercritical fluid reactor.
    Type: Grant
    Filed: March 30, 2015
    Date of Patent: November 6, 2018
    Assignees: The University of Chicago, The University of North Carolina at Chapel Hill
    Inventors: Wenbin Lin, Joseph M. Falkowski, Takahiro Sawano
  • Publication number: 20150132856
    Abstract: The preparation of silver quantum clusters embedded in organic-templated-boehmite-nanoarchitecture (OTBN) and its use as a sensor for quantity of water flow measured by change of color in visible light upon flow of contaminated water have been provided. Silver quantum clusters-embedded OTBN are highly luminescent. Since the quantum clusters are embedded in the matrix, they are highly stable over a long period of time. The composition described here is utilized in the form of a device for ‘visible/ultraviolet light color change-based detection’ upon passage of water through a water purification device. Upon interaction with ions present in water, luminescent silver clusters undergo chemical transformation to Ag2S nanoparticles. The transformation is reflected in the form of visible color change (from pink to black) and luminescence quenching (from red emission to negligible luminescence).
    Type: Application
    Filed: April 17, 2013
    Publication date: May 14, 2015
    Inventors: Thalappil Pradeep, Leelavathi Annamalai, Mohan Udhaya Sankar, Chaudhary Amrita, n/a Anshup, Thumu Udayabhaskara Rao
  • Patent number: 9012239
    Abstract: Element tags based on novel metal-polymer conjugates are provided for elemental analysis of analytes, including ICP-MS. A polymer backbone is functionalized to irreversibly bind metals that are selected prior to use by the user. The polymer is further functionalized to attach a linker which allows for attachment to antibodies or other affinity reagents. The polymer format allows attachment of many copies of a given isotope, which linearly improves sensitivity. The metal-polymer conjugate tags enable multiplexed assay in two formats: bulk assay, where the average biomarker distribution in the sample is diagnostic, and single cell format to distinguish a rare (for example a diseased) cell in a complex sample (for example, blood).
    Type: Grant
    Filed: May 28, 2007
    Date of Patent: April 21, 2015
    Assignee: Fluidigm Canada Inc.
    Inventors: Mitchell A. Winnik, Mark Nitz, Vladimir Baranov, Xudong Lou
  • Publication number: 20150104792
    Abstract: A fluorimetric system, apparatus and method are disclosed to measure an analyte concentration in a sample. A sensor reagent housing is also disclosed which comprises a channel and a porous medium having an analysis chemistry reagent, such as a nucleic acid analysis chemistry reagent. The apparatus and system are portable for field use, with an apparatus housing having a size adapted to fit into a user's hand. An apparatus also includes a sensing chamber and cover, a user interface, a light source; a photomultiplier tube, an amplifier, an A/D converter, a memory, and a processor. In various embodiments, the processor performs a data fitting, determines a sample reaction rate parameter, and determines the analyte concentration from a comparison of the sample reaction rate parameter with stored calibration data. The processor may also generate the calibration data and site-specific offset factors, and modify the calibration data using an offset factor.
    Type: Application
    Filed: December 22, 2014
    Publication date: April 16, 2015
    Inventors: Debapriya Mazumdar, David G. Kellner
  • Patent number: 9005983
    Abstract: The present invention provides an electrochemical sensor having a solid electrically conductive substrate and a compound immobilized thereon which has binding affinity for an analyte species to be detected and also displays electrochemical behavior which is modified upon binding of that analyte species, so that binding of an analyte species can be detected by measuring electrochemical properties, such as by voltammetry. Desirably the immobilized compound contains both a first moiety with binding affinity for the analyte and a separate second moiety which is a redox system whose electrochemical oxidation/reduction properties become modified when the first moiety binds the analyte. The analyte binding moiety may be a diol or polyol and preferably is a sugar. The electrochemical sensor finds use in methods of analyzing reservoir and process fluids, particularly at a subterranean location. The electrochemical sensor may be a component of a downhole tool, adapted for deployment downhole.
    Type: Grant
    Filed: August 26, 2009
    Date of Patent: April 14, 2015
    Assignee: Schlumberger Technology Corporation
    Inventors: Kay McGuinness, Nathan Lawrence, Andrew Meredith
  • Patent number: 8999717
    Abstract: A composition includes a quantum cluster of Agm or Aun, one or more protector molecules; and a molecular cavity partially or wholly surrounding the quantum cluster. A method for preparing the quantum clusters includes adding a first amount of glutathione to a gold salt, a silver salt, or a mixture thereof to form a mixture; adding a reducing agent to the mixture to form a precipitate; and mixing the precipitate with a second amount of glutathione and a cyclodextrin to form a composition. Devices are prepared from the quantum clusters, and the devices may be used in methods of authentification of articles.
    Type: Grant
    Filed: February 14, 2011
    Date of Patent: April 7, 2015
    Assignee: Indian Institute of Technology Madras
    Inventors: Pradeep Thalappil, Shibu Sidharth Edakkattuparambil
  • Patent number: 8980639
    Abstract: The present invention is concerned with a method of discriminating between, in a surface of a transition metal alloy, transition metals in different oxidation states using surface sensor molecules adapted to associate selectively with one of the transition metals. In particular, the present invention provides a method of identifying degradation in aircraft components such as turbine blades, engine casings and aerofoils. In embodiments, a surface sensor molecule comprising an oxidation state discriminating group, such as an imidazole, and a fluorescein probe is applied in aqueous solution to the surface of a service-run Ni alloy aircraft component. The sensor molecule selectively associates with transition metals in oxidation states greater than zero such that fluorescence imaging can be used to identify areas of degradation.
    Type: Grant
    Filed: April 16, 2010
    Date of Patent: March 17, 2015
    Assignee: Rolls-Royce PLC
    Inventors: Daniel Clark, Justin Burrows
  • Patent number: 8975082
    Abstract: Compositions comprising a tripeptide having the sequence XC1C2; wherein X is any amino acid such that XC1C2 is capable of binding a metal in a square planar orientation or square pyramidal orientation or both; and wherein C1 and C2 are the same or different; and wherein C1 and C2 individually are chosen from a cysteine and a cysteine-like nonnatural amino acid, as well as metal-XC1C2 complexes and methods for forming such complexes.
    Type: Grant
    Filed: March 23, 2012
    Date of Patent: March 10, 2015
    Assignee: University of Kansas
    Inventors: Jennifer Ann Stowell Laurence, Anthony Andrew Vartia, Mary Elizabeth Krause
  • Patent number: 8945937
    Abstract: A method of analyzing graphene includes providing a first graphene structure including graphene having grains and grain boundaries, and a support portion for supporting the graphene, generating a second graphene structure by oxidizing the first graphene structure, and detecting a shape of the graphene.
    Type: Grant
    Filed: May 29, 2013
    Date of Patent: February 3, 2015
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Young-hee Lee, Gang-hee Han, Dinh Loc Duong
  • Patent number: 8889414
    Abstract: Methods for determining metabolic properties of living cells through the uptake of semiconductor nanocrystals by cells. Generally the methods require a layer of neutral or hydrophilic semiconductor nanocrystals and a layer of cells seeded onto a culture surface and changes in the layer of semiconductor nanocrystals are detected. The observed changes made to the layer of semiconductor nanocrystals can be correlated to such metabolic properties as metastatic potential, cell motility or migration.
    Type: Grant
    Filed: October 30, 2002
    Date of Patent: November 18, 2014
    Assignee: The Regents of the University of California
    Inventors: A. Paul Alivisatos, Carolyn A. Larabell, Wolfgang J. Parak, Mark Le Gros, Rosanne Boudreau
  • Patent number: 8765480
    Abstract: A method for recovering a metal, capable of recovering a metal easily without requiring the use of an organic medium, is provided. A first complex between a first chelating agent and a metal present in a sample is formed in a first mixture prepared by mixing the first chelating agent and the sample. Then, the first complex is recovered from the first mixture, and a second complex between the metal derived from the first complex and a second chelating agent is formed in a second mixture prepared by mixing the first complex and an aqueous solution of the second chelating agent. The aqueous solution is under the pH conditions where the first chelating agent can be insoluble in the aqueous solution. Then, a liquid fraction containing the second complex is recovered from the second mixture. Thus, the metal can be recovered.
    Type: Grant
    Filed: April 2, 2012
    Date of Patent: July 1, 2014
    Assignee: ARKRAY, Inc.
    Inventor: Yuka Shimomura
  • Patent number: 8679849
    Abstract: This disclosure discloses a method and a device for the detection of heavy metal ions in water. The method includes: providing a detection material, wherein the detection material includes a hydrophilic layer which is at least partially covered by a hydrophobic layer formed from a long-chain compound selected from the group consisting of a long-chain thiol, a long-chain fatty acid and combinations thereof, and wherein a detection area is an area covered by the hydrophobic layer, and the detection area has a surface having an initial contact angle with water of more than or equal to about 120°; contacting the detection area with an aqueous solution sample; determining whether the surface of the detection area has a hydrophobicity-hydrophilicity change after contact with the aqueous solution sample; and deciding whether heavy metal ions exist in the aqueous solution sample according to the determination.
    Type: Grant
    Filed: January 11, 2012
    Date of Patent: March 25, 2014
    Assignee: Sony Corporation
    Inventors: Xiaoke Zhang, Hisashi Kajiura, Yongming Li
  • Patent number: 8652849
    Abstract: This invention relates to a composite material that comprises a support member that has a plurality of pores extending through the support member and, located in the pores of the support member, and filling the pores of the support member, a macroporous cross-linked gel. The invention also relates to a process for preparing the composite material described above, and to its use. The composite material is suitable, for example, for separation of substances, for example by filtration or adsorption, including chromatography, for use as a support in synthesis or for use as a support for cell growth.
    Type: Grant
    Filed: October 14, 2008
    Date of Patent: February 18, 2014
    Assignee: Natrix Separations Inc.
    Inventors: Ronald F. Childs, Carlos Filipe, Raja Ghosh, Alicja M. Mika, Jinsheng Zhou, Elena N. Komkova, Marcus Y. Kim, Tapan K. Dey
  • Publication number: 20130323850
    Abstract: The present disclosure relates to an oligonucleotide-immobilized microoscillator for detecting silver ions and a method for detecting silver ions using resonance of the same. A DNA including a thiol-terminated cytosine is immobilized on the surface of the microoscillator. In accordance with the present disclosure, silver nanoparticles detrimental to the human body and environment can be detected and quantified through a simple method based on the mechanical property of resonance frequency. Since trace silver nanoparticles below 1 nM can be detected with high sensitivity and selectivity, it may be usefully applied as a biosensor for detecting the toxic material.
    Type: Application
    Filed: November 29, 2012
    Publication date: December 5, 2013
    Applicant: Korea University Research and Business Foundation
    Inventors: Sung Soo Na, Jinsung Park, Kue-Whan Jang, Wook Choi
  • Publication number: 20130210793
    Abstract: The present invention provides compounds of Formula I: along with compositions comprising the same and methods of using the same, such as for photodynamic therapy in the treatment of cancer.
    Type: Application
    Filed: March 21, 2013
    Publication date: August 15, 2013
    Applicant: Duke University
    Inventor: Duke University
  • Publication number: 20130210157
    Abstract: Disclosed herein are mixed metal-organic frameworks, Zn3(BDC)3[Cu(SalPycy)] and Zn3(CDC)3[Cu(SalPycy)], wherein BDC is 1,4-benzenedicarboxylate, CDC is 1,4-cyclohexanedicarboxylate, and SalPyCy is a ligand of the formula: These are useful for applications such as selective gas storage, selective molecular separations, and selective detection of molecules, including enantioselective applications thereof.
    Type: Application
    Filed: January 17, 2013
    Publication date: August 15, 2013
    Applicant: The Board of Regents of the University of Texas System
    Inventor: The Board of Regents of the University of Texas System
  • Patent number: 8497131
    Abstract: Surface Enhanced Spectroscopy-Active Composite Nanoparticles (SACN) comprising: core/shell nanoparticles comprising nanoparticle cores covered with shells, wherein the cores and the shells may comprise the same or different materials; at least one Raman-active reporter molecule associated with said core/shell nanoparticle; and an SiO2 encapsulant which encapsulates the core/shell nanoparticle and the at least one Raman-active reporter molecule, are described.
    Type: Grant
    Filed: April 25, 2005
    Date of Patent: July 30, 2013
    Assignee: Becton, Dickinson and Company
    Inventors: Michael J. Natan, Sharron Gaynor Penn, R. Griffith Freeman, Gabriela Chakarova, William E. Doering, Ian D. Walton
  • Patent number: 8481324
    Abstract: The present invention provides a system containing an array of chemically sensitive sensors based on coated single walled carbon nanotubes, for measuring volatile organic compounds indicative of renal failure. Methods of breath analysis for diagnosing chronic, acute and end-stage renal failure are disclosed.
    Type: Grant
    Filed: December 2, 2009
    Date of Patent: July 9, 2013
    Assignee: Technion Research and Development Foundation Ltd.
    Inventors: Hossam Haick, Zaid Abassi, Farid Nakhoul
  • Publication number: 20130130392
    Abstract: A composition includes a quantum cluster of Agm or Aun, one or more protector molecules; and a molecular cavity partially or wholly surrounding the quantum cluster. A method for preparing the quantum clusters includes adding a first amount of glutathione to a gold salt, a silver salt, or a mixture thereof to form a mixture; adding a reducing agent to the mixture to form a precipitate; and mixing the precipitate with a second amount of glutathione and a cyclodextrin to form a composition. Devices are prepared from the quantum clusters, and the devices may be used in methods of authentification of articles.
    Type: Application
    Filed: February 14, 2011
    Publication date: May 23, 2013
    Inventors: Pradeep Thalappil, Shibu Sidharth Edakkattuparambil
  • Patent number: 8445678
    Abstract: Disclosed are 2-quinoxalinol salen compounds and in particular 2-quinoxalinol salen Schiff-base ligands. The disclosed 2-quinoxalinol salen compounds may be utilized as ligands for forming complexes with cations, and further, the formed complexes may be utilized as catalysts for oxidation reactions. The disclosed 2-quinoxalinol salen compounds also may be conjugated to solid supports and utilized in methods for selective solid-phase extraction or detection of cations.
    Type: Grant
    Filed: October 11, 2011
    Date of Patent: May 21, 2013
    Assignee: Auburn University
    Inventors: Anne E. V. Gorden, Xianghong Wu
  • Publication number: 20130116138
    Abstract: Described herein are small peptide domains and consensus sequences that bind small target molecules of industrial importance, e.g., metals such as nickel, ? carotene, and isoflavones such as genistein. Also described are fusion proteins containing such binding domains fused to proteins or to peptide domains like GST or GBD that bind other ligands and can be used to immobilize the target binding domain on a support. One class of fusion proteins that is useful in industrial settings are fusions that contain concatemers of target binding domains, which increases the binding equivalents per molecule.
    Type: Application
    Filed: January 28, 2011
    Publication date: May 9, 2013
    Applicants: Archer-Daniels-Midland Company, Iowa State University Research Foundation, Inc.
    Inventors: Thomas P. Binder, Aragula Gururaj Rao, Yasufumi Yamamoto, Paul Hanke
  • Patent number: 8426211
    Abstract: The present invention relates to a method of detecting soil nutrients or soil nutrients in soil from reflected light, and also includes systems for the measurement, calculation and transmission of data relating to or carrying out that method.
    Type: Grant
    Filed: February 8, 2010
    Date of Patent: April 23, 2013
    Assignee: Bowling Green State University
    Inventors: B. B. Maruthi Sridhar, Robert K. Vincent
  • Patent number: 8409863
    Abstract: A system to selectively deliver relatively small analyte molecules of interest to a SERS-active nanoparticle surface while excluding dozens to hundreds of other species in the environment. In particular, the present invention provides a permselective film that renders the particles of interest as viable small molecule optically addressable sensors.
    Type: Grant
    Filed: December 14, 2006
    Date of Patent: April 2, 2013
    Assignee: Becton, Dickinson and Company
    Inventors: Michael J. Natan, Marcelo Eduardo Piotti
  • Patent number: 8404491
    Abstract: A luminescent chemical sensor integrated with at least one molecular trap. The luminescent chemical sensor includes at least one molecular trap and at least one metallic-nanofinger device integrated with at least one molecular trap. The molecular trap includes a plurality of electrodes that trap at least one analyte molecule. The metallic-nanofinger device includes a substrate, and a plurality of nanofingers coupled with the substrate. A nanofinger of the plurality includes a flexible column, and a metallic cap coupled to an apex of the flexible column. At least the nanofinger and a second nanofinger of the plurality of nanofingers are to self-arrange into a close-packed configuration with the analyte molecule. A method for using, and a chemical-analysis apparatus including the luminescent chemical sensor are also provided.
    Type: Grant
    Filed: October 29, 2010
    Date of Patent: March 26, 2013
    Assignee: Hewlett-Packard Development Company, L.P.
    Inventors: Zhiyong Li, Michael Josef Stuke, Shih-Yuan Wang, Huei Pei Kuo
  • Publication number: 20130059392
    Abstract: Pyridine-containing polyenes and their applications as metal ion sensors. These polyenes are practically nonluminescent in the solution state but become highly emissive as nanoparticle suspensions in aqueous solutions or thin films in the solid state, due to aggregation-induced emission (AIE). The nanoaggregates of these compounds can work as “turn-off” fluorescent chemosensors for metal ions and display different fluorescence responses to various metal ions. For example, a characteristic red shift in the emission spectra is observed with a terpyridine-containing luminogen in the presence of Zn2+. However, the terpyridine-containing luminogen displays a magenta color upon selectively binding with Fe2+. This allows easy identification of both Zn2+ and Fe2+ ions in aqueous media. The function of the polyenes can be easily tuned by altering the substituent groups. Due to their AIE properties, these polyenes can be used in aqueous solutions and in solid substrates for metal sensing.
    Type: Application
    Filed: September 4, 2012
    Publication date: March 7, 2013
    Applicant: THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Benzhong TANG, Yuning HONG, Wai Tung LEUNG
  • Patent number: 8389298
    Abstract: Methods using chemiluminescent label compounds and chemiluminescent labeled conjugates are provided. The compounds comprise an acridan ring bearing an exocyclic ketene dithioacetal group and further contain a labeling substituent which permits attachment to compounds of interest. The novel chemiluminescent compounds and labeled conjugates are convenient to prepare, are highly stable, and generate chemiluminescence rapidly on demand. The compounds and conjugates are useful in assays of an analyte in a sample and in assays employing labeled specific binding pairs.
    Type: Grant
    Filed: March 19, 2010
    Date of Patent: March 5, 2013
    Assignee: Lumigen, Inc.
    Inventors: Hashem Akhavan-Tafti, Renuka De Silva, Wenhua Xie
  • Publication number: 20130034909
    Abstract: Provided is a diagnosis method for an oil-filled electrical apparatus, which is for evaluating the degree of danger of copper sulfide being generated within the oil-filled electrical apparatus, comprising: a first step for detecting a specific compound contained within insulating oil inside the oil-filled electrical apparatus; a second step for evaluating the possibility of copper sulfide being generated inside the oil-filled electrical apparatus, on the basis of the result detected by the first step; and a third step for diagnosing the degree of danger of a malfunction occurring in the oil-filled electrical apparatus, on the basis of the evaluation result obtained in the second step. The specific compound contains dibenzyl disulfide and/or a reaction product of a radical resulting from dibenzyl disulfide, and di-tert-butyl-p-cresol and/or a reaction product of a radical resulting from di-tert-butyl-p-cresol, or, di-tert-butyl-phenol and/or a reaction product of a radical resulting from di-tert-butyl-phenol.
    Type: Application
    Filed: May 10, 2011
    Publication date: February 7, 2013
    Applicant: Mitsubishi Electric Corporation
    Inventors: Satoru Toyama, Junji Tanimura, Fukutaro Kato, Tsuyoshi Amimoto, Eiichi Nagao, Takeshi Kawashima, Noboru Hosokawa
  • Patent number: 8278111
    Abstract: Compositions comprising a tripeptide having the sequence XC1C2; wherein X is any amino acid such that XC1C2 is capable of binding a metal in a square planar orientation or square pyramidal orientation or both; and wherein C1 and C2 are the same or different; and wherein C1 and C2 individually are chosen from a cysteine and a cysteine-like nonnatural amino acid, as well as metal-XC1C2 complexes and methods for forming such complexes.
    Type: Grant
    Filed: December 30, 2011
    Date of Patent: October 2, 2012
    Assignee: University of Kansas
    Inventors: Jennifer Ann Stowell Laurence, Anthony Andrew Vartia, Mary Elizabeth Krause
  • Patent number: 8263410
    Abstract: Disclosed is an innovative method for detecting metal ions based on selective plasmonic resonance energy transfer between metal-ligand complexes and a single nanoplasmonic particle as a probe. The selective plasmonic resonance energy transfer occurs if a resonance frequency matching condition between the single nanoplasmonic particle and the metal-ligand complexes is satisfied.
    Type: Grant
    Filed: July 30, 2009
    Date of Patent: September 11, 2012
    Assignees: Industry-University Cooperation Foundation Sogang University, University of California, Berkeley
    Inventors: Taewook Kang, Luke P. Lee, Yeonho Choi, Younggeun Park
  • Patent number: 8232105
    Abstract: Certain embodiments described herein are directed to a reagent that includes an effective amount of an adsorber to remove interfering species present during heavy metal level measurement in a fluid sample. In some examples, the reagent can include an effective amount of an adsorber to remove a suitable amount of glutathione from the fluid sample such that the glutathione does not interfere with measurements of lead levels in the fluid sample.
    Type: Grant
    Filed: September 30, 2010
    Date of Patent: July 31, 2012
    Assignee: Magellan Biosciences Point-of-Care, Inc.
    Inventor: W James Scott
  • Publication number: 20120184040
    Abstract: This disclosure discloses a method and a device for the detection of heavy metal ions in water. The method includes: providing a detection material, wherein the detection material includes a hydrophilic layer which is at least partially covered by a hydrophobic layer formed from a long-chain compound selected from the group consisting of a long-chain thiol, a long-chain fatty acid and combinations thereof, and wherein a detection area is an area covered by the hydrophobic layer, and the detection area has a surface having an initial contact angle with water of more than or equal to about 120°; contacting the detection area with an aqueous solution sample; determining whether the surface of the detection area has a hydrophobicity-hydrophilicity change after contact with the aqueous solution sample; and deciding whether heavy metal ions exist in the aqueous solution sample according to the determination.
    Type: Application
    Filed: January 11, 2012
    Publication date: July 19, 2012
    Applicant: SONY CORPORATION
    Inventors: Xiaoke Zhang, Hisashi Kajiura, Yongming Li
  • Patent number: 8187890
    Abstract: Methods for rapid sensing of dissolved toxic heavy metals use a hybrid inorganic material (“HIM”), which is synthesized from hydrated iron oxide (“HFO”) and calcium magnesium silicate. HIM thus synthesized is used in sensing dissolved toxic heavy metals. Water containing toxic heavy metals (e.g., lead, copper, zinc, nickel, etc.) is passed through a sorbent bed of HIM, whereupon it shows a sharp drop in pH after a certain length of time. The presence of HFO and calcium magnesium silicates in HIM synergistically provide a precipitous drop in pH, which is characteristic of the concentration and type of toxic heavy metal. Therefore, observing a change in pH indicates the presence and identity of heavy metal ions in a test water sample.
    Type: Grant
    Filed: June 4, 2008
    Date of Patent: May 29, 2012
    Assignee: Lehigh University
    Inventors: Arup K. Sengupta, Prasaun K. Chatterje
  • Patent number: 8137759
    Abstract: The invention is drawn to novel nanostructures comprising hollow nanospheres and nanotubes for use as chemical sensors, conduits for fluids, and electronic conductors. The nanostructures can be used in microfluidic devices, for transporting fluids between devices and structures in analytical devices, for conducting electrical currents between devices and structure in analytical devices, and for conducting electrical currents between biological molecules and electronic devices, such as bio-microchips.
    Type: Grant
    Filed: April 5, 2007
    Date of Patent: March 20, 2012
    Assignee: The Regents of the University of California
    Inventors: Jin Z. Zhang, Adam Schwartzberg, Tammy Y. Olson
  • Publication number: 20120064632
    Abstract: The present invention provides an electrochemical sensor having a solid electrically conductive substrate and a compound immobilized thereon which has binding affinity for an analyte species to be detected and also displays electrochemical behaviour which is modified upon binding of that analyte species, so that binding of an analyte species can be detected by measuring electrochemical properties, such as by voltammetry. Desirably the immobilised compound contains both a first moiety with binding affinity for the analyte and a separate second moiety which is a redox system whose electrochemical oxidation/reduction properties become modified when the first moiety binds the analyte. The analyte binding moiety may be a diol or polyol and preferably is a sugar. The electrochemical sensor finds use in methods of analysing reservoir and process fluids, particularly at a subterranean location. The electrochemical sensor may be a component of a downhole tool, adapted for deployment downhole.
    Type: Application
    Filed: August 26, 2009
    Publication date: March 15, 2012
    Applicant: Schlumberger Technology Corporation
    Inventors: Kay Robinson, Nathan Lawrence, Andrew Meredith
  • Publication number: 20120052513
    Abstract: The present technology relates gold sub-nanoclusters comprising a gold core and one or more thiolates bound to the gold core, wherein the gold core consists essentially of 23 gold atoms. Methods of preparing and using such sub-nanoclusters are also provided.
    Type: Application
    Filed: August 24, 2010
    Publication date: March 1, 2012
    Inventors: Pradeep THALAPPIL, Madathumpady Abubaker Habeeb Muhammed
  • Publication number: 20120045840
    Abstract: Applicants have produced a chromophore and a polymer that are highly sensitive to the presence of various agents, including organophosphates, pesticides, neurotoxins, metal ions, some explosives, and biological toxins. The detection is accomplished by detecting a change in the fluorescence characteristics of the chromophore or polymer when in the presence of the agent to be detected. The chromophore and polymer may be incorporated into sensors of various types, and they are adaptable for potential field use in areas where detection of these types of agents is desired.
    Type: Application
    Filed: February 7, 2011
    Publication date: February 23, 2012
    Applicant: NDSU-RESEARCH FOUNDATION
    Inventors: Johnson Thomas, Philip Boudjouk
  • Publication number: 20120040467
    Abstract: The present invention is concerned with a method of discriminating between, in a surface of a transition metal alloy, transition metals in different oxidation states using surface sensor molecules adapted to associate selectively with one of the transition metals. In particular, the present invention provides a method of identifying degradation in aircraft components such as turbine blades, engine casings and aerofoils. In embodiments, a surface sensor molecule comprising an oxidation state discriminating group, such as an imidazole, and a fluorescein probe is applied in aqueous solution to the surface of a service-run Ni alloy aircraft component. The sensor molecule selectively associates with transition metals in oxidation states greater than zero such that fluorescence imaging can be used to identify areas of degradation.
    Type: Application
    Filed: April 16, 2010
    Publication date: February 16, 2012
    Inventors: Daniel Clark, Justin Burrows
  • Patent number: 8110250
    Abstract: A chemical sensor that utilizes localized surface Plasmon resonance including a substrate, metal-containing particles and dielectric particles, wherein the metal-containing particles and the dielectric particles are disposed on the substrate, is used as a chemical sensor element. Thereby, a chemical sensor element having a sufficient detecting sensitivity when localized surface Plasmon resonance is utilized, and a method for the fabrication thereof, can be provided.
    Type: Grant
    Filed: February 23, 2011
    Date of Patent: February 7, 2012
    Assignee: Canon Kabushiki Kaisha
    Inventors: Tetsunori Ojima, Miki Ogawa
  • Patent number: 8110402
    Abstract: Compositions comprising a tripeptide having the sequence XC1C2; wherein X is any amino acid such that XC1C2 is capable of binding a metal in a square planar orientation or square pyramidal orientation or both; and wherein C1 and C2 are the same or different; and wherein C1 and C2 individually are chosen from a cysteine and a cysteine-like nonnatural amino acid, as well as metal-XC1C2 complexes and methods for forming such complexes.
    Type: Grant
    Filed: May 13, 2009
    Date of Patent: February 7, 2012
    Assignee: University of Kansas
    Inventors: Jennifer Ann Stowell Laurence, Anthony Andrew Vartia, Mary Elizabeth Krause
  • Publication number: 20120028362
    Abstract: Disclosed are 2-quinoxalinol salen compounds and in particular 2-quinoxalinol salen Schiff-base ligands. The disclosed 2-quinoxalinol salen compounds may be utilized as ligands for forming complexes with cations, and further, the formed complexes may be utilized as catalysts for oxidation reactions. The disclosed 2-quinoxalinol salen compounds also may be conjugated to solid supports and utilized in methods for selective solid-phase extraction or detection of cations.
    Type: Application
    Filed: October 11, 2011
    Publication date: February 2, 2012
    Applicant: AUBURN UNIVERSITY
    Inventors: Anne E. V. Gorden, Xianghong Wu
  • Patent number: 8101415
    Abstract: A method of adjusting a final signal value measured on a lateral flow assay test strip, by: identifying a pre-determined calibration method for the test strip, wherein the pre-determined calibration method corresponds to the manufacturing lot from which the test strip has been made; measuring signal values while performing a lateral flow assay reaction on a test strip; determining a final signal value; and adjusting the final signal value based upon the identified pre-selected calibration method for the test strip.
    Type: Grant
    Filed: July 5, 2005
    Date of Patent: January 24, 2012
    Assignee: Bayer HealthCare LLC
    Inventor: Benjamin R. Irvin
  • Publication number: 20120009683
    Abstract: The present invention provides fluorogenic compounds for the detection of target metal ions wherein the compounds exhibit a Stokes shift greater than 50 nm and the detectable signal is modulated by photoinduced electron transfer (PET). The present compounds consist of three functional elements, the ion sensing moiety (chelating moiety), the reporter moiety (fluorophore or fluorescent protein) and spacer or linker between the sensing and reporter moieties of the present compound that allows for PET upon binding of a metal ion and excitation by an appropriate wavelength.
    Type: Application
    Filed: July 29, 2011
    Publication date: January 12, 2012
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: Kyle Richard GEE, Vladimir MARTIN
  • Patent number: 8071387
    Abstract: Electrodeposition baths, systems and methods are provided. In some embodiments, the baths, systems and methods are used to deposit metal alloy coatings.
    Type: Grant
    Filed: May 27, 2011
    Date of Patent: December 6, 2011
    Assignee: Xtalic Corporation
    Inventors: Alan C. Lund, Nazila Dadvand, John Cahalen, Daniel J. Montville
  • Patent number: 8062597
    Abstract: This invention relates to a discoloration indicator for checking the life span of a desulfurization adsorbent, and a desulfurization reactor and a desulfurization system including the same, and specifically, to a discoloration indicator for checking the life span of a desulfurization adsorbent able to effectively adsorb and remove organic sulfur compounds from fossil fuels, including natural gas or LPG containing the organic sulfur compound, and to a desulfurization reactor and a desulfurization system including the same. This invention makes it possible to remove the organic sulfur compound using the desulfurization adsorbent and to check the replacement time of the adsorbent with the naked eye or using an electrical signal, and thus may be applied to the treatment of natural gas or LPG requiring desulfurization, and also to hydrogen generators for home fuel cell generation systems or distributed fuel cell generation systems requiring that devices be simple, or requiring unmanned operation.
    Type: Grant
    Filed: July 11, 2007
    Date of Patent: November 22, 2011
    Assignee: SK Energy Co., Ltd.
    Inventors: Myung Jun Kim, Young Seek Yoon, Jin Hong Kim
  • Publication number: 20110281363
    Abstract: A method for detecting and measuring a metal ion in an aqueous medium includes derivatizing a solid phase extraction material with a reactive material that undergoes a chemical reaction when contacted with the metal ion. The solid phase extraction material and the reactive material are positioned in an aqueous medium containing the metal ion, such that the metal ion contacts the reactive material and causes it to chemically react. The reaction of the reactive material is detected by optical spectroscopy to detect and measure the metal ion.
    Type: Application
    Filed: April 16, 2011
    Publication date: November 17, 2011
    Inventors: Alice E. Bruce, Carl P. Tripp, Mitchell R.M. Bruce, Amer A.G. Al Abdel Hamid, Asela C. Maha Acharige
  • Publication number: 20110263032
    Abstract: The present invention discloses a method and composition for testing the wear on mechanical hardware. During the testing method a metal oxidant is applied the mechanical hardware being tested which deposits onto the mechanical and can be visually detected. One of the properties of the metal oxidant is that it is a substantially non-flow or non-drip medium that can be applied in situ with reduced risk to surrounding hardware.
    Type: Application
    Filed: December 9, 2009
    Publication date: October 27, 2011
    Applicant: The Commonwealth of Australia
    Inventor: Darren Gerrard
  • Patent number: 8043866
    Abstract: A object of the present invention is to provide an immunochromatography method that makes it possible to rapidly detect an ultratrace amount of an analyte that has been impossible to analyze by conventional immunochromatography methods. The present invention provides an immunochromatography method, which comprises developing an analyte and a labeling substance which is modified with a first binding substance against the analyte in a mixed state on a porous carrier and capturing the analyte and the label at a reaction site on the porous carrier having a second binding substance against the analyte or a substance capable of binding to the first binding substance against the analyte, so as to detect the analyte, wherein the labeling substance having an average particle size of 1 ?m or more and 20 ?m or less is detected.
    Type: Grant
    Filed: September 29, 2008
    Date of Patent: October 25, 2011
    Assignee: Fujifilm Corporation
    Inventors: Takayoshi Oyamada, Junichi Katada
  • Patent number: 8043860
    Abstract: This application relates to vaprochromic coordination polymers useful for analyte detection. The vapochromism may be observed by visible color changes, changes in luminescence, and/or spectroscopic changes in the infrared (IR) signature. One or more of the above chromatic changes may be relied upon to identify a specific analyte, such as a volatile organic compound or a gas. The chromatic changes may be reversible to allow for successive analysis of different analytes using the same polymer. The polymer has the general formula MW[M?X(Z)Y]N wherein M and M? are the same or different metals capable of forming a coordinate complex with the Z moiety; Z is selected from the group consisting of halides, pseudohalides, thiolates, alkoxides and amides; W is between 1-6; X and Y are between 1-9; and N is between 1-5. Optionally, an organic ligand may be bound to M. In alternative embodiments of the invention M may be a transition metal, such as Cu and Zn.
    Type: Grant
    Filed: July 8, 2008
    Date of Patent: October 25, 2011
    Assignee: Simon Fraser University
    Inventors: Julie Lefebvre, Michael Iacov Katz, Daniel B. Leznoff
  • Patent number: 8034621
    Abstract: The present technology provides a dual chemical sensor for zinc and nickel ions and a chemical sensor for copper ions. Also provided are methods of making and using the chemical sensors. The chemical sensors have the structure of formula I, wherein R1, and R2 are defined as set forth herein.
    Type: Grant
    Filed: August 18, 2009
    Date of Patent: October 11, 2011
    Assignee: Indian Institute of Technology
    Inventors: Chebrolu Pulla Rao, Roymon Joseph