And Means For Introducing Either Material Or Auxiliary Fluid Into Bowls Patents (Class 494/17)
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Patent number: 10724942Abstract: According to one embodiment, an inspection apparatus includes a socket, a first arm, and a recognition device. The socket has at least one container holding part for holding a container containing an object. The first arm includes at least two links of which ends are connected. The first arm is able to install the container into the container holding part when the links are in a first posture and to reinstall the container into the container holding part when the links are in a second posture different from the first posture. The recognition device obtains at least recognition results indicating respective positions of the object when the container is installed into the container holding part in the first posture and the second posture.Type: GrantFiled: August 28, 2017Date of Patent: July 28, 2020Assignee: Kabushiki Kaisha ToshibaInventors: Masato Akita, Takamitsu Sunaoshi, Misato Ishikawa
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Patent number: 10258997Abstract: A device provides selective modes of vibrational oscillations and centrifugal rotations for preparing analysis samples. The device includes a base, an elastic connection body, a group of a synchronous unidirectional bearing inner ring and a synchronous unidirectional bearing outer ring, a group of an eccentric unidirectional bearing inner ring and an eccentric unidirectional bearing outer ring, and a synchronous fixed ring and a motor on the base. The eccentric unidirectional bearing outer ring is connected to a sample plate for holding the analysis samples.Type: GrantFiled: August 11, 2016Date of Patent: April 16, 2019Assignee: BEIJING ABILITY TECHNOLOGY CO., LTD.Inventors: Dongming Zhang, Shanshan Zhang, Yuemeng Liu
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Patent number: 9779927Abstract: Method for loading a sample of a target compound into a nanospray emitter tube for analysis by nanospray ionization mass spectrometry, wherein a cartridge having a fluid container, an inlet and an outlet is mounted onto a nanospray emitter tube on a nanospray emitter mount to form a nanospray emitter tube assembly, the assembly is mounted on a micro-centrifuge tube, a volume of the sample to be analyzed is loaded into the fluid container and the micro-centrifuge tube is spun on a centrifuge to transfer the sample into the nanospray emitter tube.Type: GrantFiled: April 18, 2013Date of Patent: October 3, 2017Assignee: NEW OBJECTIVE, INC.Inventor: Gary A. Valaskovic
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Publication number: 20150094196Abstract: A revolver component for a reagent vessel has at least one first chamber that is configured to be filled at least partly with at least one liquid. The first chamber is formed or fitted such that a first chamber filling volume that is configured to be filled with the at least one liquid is delimited by an expansion-variable boundary. The expansion-variable boundary has a spatial expansion that can be reversibly adjusted such that the filling volume is configured to be varied. Reagent vessel insert parts and reagent vessels are also disclosed. Methods for centrifuging a material and for pressure treating a material are also disclosed.Type: ApplicationFiled: February 21, 2013Publication date: April 2, 2015Inventors: Martina Daub, Guenter Roth, Arne Kloke, Nils Paust, Juergen Steigert, Felix von Stetten
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Publication number: 20150031521Abstract: The invention relates to a sample carrier centrifuge for a sample carrier (24) that has at least one sample channel (26) extending along an essentially central sample channel longitudinal axis (P), having a sample carrier receptacle (14), which can be rotated around a rotation axis (R) and has a holding section (38) into which the sample carrier (24) can be inserted in a loading procedure when the sample carrier receptacle (14) is not rotating, in which section the sample carrier (24) is held in the loaded state of the sample carrier receptacle (14), and from which section the sample carrier (24) can be removed in an unloading procedure, which is characterized in that a platform (22) of the sample carrier centrifuge (10), which is embodied for supporting the sample carrier centrifuge (10) in accordance with its designated use, is oriented parallel to the rotation axis (R).Type: ApplicationFiled: February 6, 2013Publication date: January 29, 2015Inventors: Zhaoqiang Wang, Friedrich Neuhäusser-Wespy
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Publication number: 20140352410Abstract: A device is disclosed for centrifugally driving liquid flow to sequentially dispense aliquots from a reservoir while the device rotates. Also disclosed is a method and system for analysing a liquid to derive an indicator of sedimentation rate of the liquid using sequential aliquoting, using the disclosed device in some embodiments. A particular application is the analysis of blood samples, including sedimentation rate and hematocrit.Type: ApplicationFiled: December 7, 2012Publication date: December 4, 2014Inventors: Nuno Alexandre Esteves Reis, Joao Manuel De Oliveira Garcia Da Fonseca
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Patent number: 8556792Abstract: A fraction collector, sample drier that automatically re-fills sample contains is described. Profiles of RPM and/or back EMF decays as a rotating but unpowered rotor comes to a stop are generated. The profiles may be generated for rotors with full, partially filled and empty sample containers. During a drying operation as the non-volatile samples are collected by evaporating the liquids more sample may be loaded while the rotor is spinning. The operation is to unpower the mechanism and measure the decay profile of PPM and/or EMF over time. A threshold may be set so that the lighter rotor will stop more quickly, and if the threshold is crossed the mechanism will load more sample into the containers.Type: GrantFiled: June 28, 2010Date of Patent: October 15, 2013Assignee: Harvard Bioscience, Inc.Inventor: Herbert J. Hedberg
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Patent number: 8540082Abstract: A centrifugal assembly is provided that can be used in common laboratory fixed angle or swinging bucket centrifuges for the separation of material, such as parasitic ova, based on particle density. The centrifugal assembly allows the fluid level to be gently adjusted to form a meniscus without disruption of the buoyant matter, such as ova. The centrifugal assembly also enables a user to easily and hygienically collect and transfer a measured amount of a sample, such as fecal material, and to break apart and mix the sample with a floatation fluid contained in a centrifuge tube.Type: GrantFiled: September 25, 2009Date of Patent: September 24, 2013Assignee: Iris International, Inc.Inventors: James Kelland, Henry Petithory, Kevin Sullivan
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Patent number: 8444934Abstract: A microfluidic flow cell for removably interfacing with a removable-member for performing a reaction therebetween. The microfluidic flow cell device comprises at least one reaction portion defining with the removable-member a reaction chamber when in an interfaced position thereof. The microfluidic flow cell comprises at least one fluid-receiving portion for receiving a fluid therein and being in fluid communication with the reaction chamber. When the microfluidic flow cell and the removable-member are in the interfaced position, the cell is adapted to allow for the fluid in the fluid-receiving portion to flow to the reaction chamber. Devices, systems and methods comprising this microfluidic flow cell are also disclosed.Type: GrantFiled: March 29, 2005Date of Patent: May 21, 2013Assignee: Universite LavalInventor: Regis Peytavi
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Patent number: 8328024Abstract: A separator that uses centrifugation to fractionate a suspension such as blood comprises a separation container and a buoy. The buoy is carried in the separation container and has a tuned density that is configured to reach an equilibrium position in a suspension. The guide surface is carried on the buoy upper surface and is inclined to an accumulation position near a buoy perimeter. The buoy suspension fractionation system can be used in a method of isolating a fraction from a suspension, and in a method for re-suspending particulates for withdrawal.Type: GrantFiled: August 4, 2011Date of Patent: December 11, 2012Assignees: Hanuman, LLC, Biomet Biologics, LLCInventors: Michael D. Leach, Randel Dorian, Jacy C. Hoeppner
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Patent number: 8152707Abstract: According to an aspect of the present invention, there is provided a bio cell cleaning centrifuge including: a motor; a rotor rotated by the motor; holders that are equipped on the rotor and that hold test tubes to be pivotable toward a rotational radial direction of the rotor; a cleaning liquid distributor mounted on the rotor to supply a cleaning liquid to the test tubes; a locking mechanism that locks the holders so that the test tubes are in a vertical state with respect to the rotational radial direction; and a controller that controls the motor and the locking mechanism, wherein the holders are configured to hold the test tubes so that central axes thereof are inclined from a rotational axis direction toward a rotational tangent direction of the rotor.Type: GrantFiled: June 19, 2008Date of Patent: April 10, 2012Assignee: Hitachi Koki Co., Ltd.Inventor: Kenji Yamada
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Patent number: 8105551Abstract: A microfluidic device and a method of fabricating the microfluidic device are provided. The microfluidic device includes: a platform including an upper substrate and a lower substrate that are bonded to face each other; a microfluidic structure obtained by forming grooves in the lower substrate; a lower substrate protrusion pattern including an outline protrusion that protrudes from the lower substrate toward the upper substrate along an outline of the microfluidic structure; and an adhesive layer disposed between the lower substrate protrusion pattern and the upper substrate in order to bond the upper substrate and the lower substrate to each other. The lower substrate protrusion pattern only supports the upper substrate, and remaining portions of the lower substrate except for the lower substrate protrusion pattern do not have structures for supporting the upper substrate.Type: GrantFiled: April 3, 2009Date of Patent: January 31, 2012Assignee: Samsung Electronics Co., LtdInventors: Jongmyeon Park, Jeonggun Lee
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Publication number: 20110067488Abstract: Systems and methods for determining the presence of a target material in a suspension are provided. In one embodiment, a system (100) for isolating a target material in suspension includes at least one tube and float system (106,108), an offset fluid (135) disposed with at least one chamber (101-104), and a centrifuge (109) for centrifugally processing the suspension disposed within the at least one tube and float system the at least one chamber.Type: ApplicationFiled: September 10, 2010Publication date: March 24, 2011Inventors: Robert A. Levine, Stephen C. Wardlaw
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Publication number: 20110045958Abstract: There is described an apparatus for automatically centrifuging test tubes containing biological material comprising a plurality of centrifuges (9, 31) functionally identical to one another yet independent and adapted to centrifuge test tubes (3) offered to an interface (5) for centrifuging test tubes (3) by means of a conveying system included in an automatic conveyor of test tubes (3). Said plurality of centrifuges (9, 31) are fitted on a turntable (10, 32) adapted to offer each centrifuge (9, 31) at a suitable loading/unloading point (100, 200) adjacent to the loading/unloading point (7, 202) of the interface (5).Type: ApplicationFiled: February 11, 2009Publication date: February 24, 2011Inventor: Gianandrea Pedrazzini
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Publication number: 20100009832Abstract: The present invention relates to improved methods for processing fluids and to a fluid processing device (1) for use in a centrifuge comprising: (a) a first holder (14) form-fit to the shape of a first tube (18) for holding said first tube (18) whereby said first tube (18) has a first cross section (A1); and (b) a second holder (22) form-fit to the shape of a second tube (26) for holding said second tube (26) whereby said second tube (26) has a second cross section (A2) that is different from said first cross section (A1). With the fluid processing devices and the methods according to the invention, it is possible to simplify the centrifugal processing steps for a given fluid processing sequence and to automate them.Type: ApplicationFiled: September 26, 2006Publication date: January 14, 2010Inventors: Andreas Schaefer, Thomas Voit, Markus Zbinden
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Patent number: 7588692Abstract: The present invention is directed to a method and system that separates first particles from second particles, or white blood cells from red blood cells, by sedimentation in a fluid chamber with debulking of one of the first or second particles or red blood cells through the inlet of the fluid chamber. The method and system further includes fractionation of the remaining particles or white blood cells into selected subsets. In one embodiment of the instant invention a blood product containing white blood cells is loaded in a separation chamber, a diluting or sedimenting agent is added to encourage rouleaux formation of any red blood cells, the cells are sedimented and the red blood cells are removed.Type: GrantFiled: February 28, 2007Date of Patent: September 15, 2009Assignee: CaridianBCT, Inc.Inventors: Glenn Delbert Antwiler, Linda A. Taylor
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Publication number: 20090215603Abstract: Centrifuges, in particular for a lubricant oil in an internal combustion engine, are provided with a housing which comprises a base, a lid forming the second part of the housing and connectable to the base and a rotor arrangeable in the housing. Each centrifuge is embodied in the form of a modular unit which is assembled with the aid of modular system parts, wherein the modular system comprises different bases, and/or different lids and/or different rotors which can be assembled in the form of different combinations in such a way that different centrifuges are obtained.Type: ApplicationFiled: August 23, 2006Publication date: August 27, 2009Inventor: Dieter Baumann
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Publication number: 20090098266Abstract: An apparatus and method for separating joined components, purifying liquid, promoting interaction between two or more components and improving combustion. The apparatus has a housing, a rotor inside of the housing, a plurality of protrusions extending from the rotor, a shaft coupled with the rotor and a prime mover for rotating the shaft. Fluid within the housing cavitates as the rotor rotates and the protrusions move through the fluid. Cavitation causes joined components within the fluid to separate, kills undesirable organisms within the fluid, promotes interaction of components within the fluid and improves combustion of a liquid fuel. The fluid and components may also be subjected to abrasion and centrifugal and impact forces for separating the components, purifying the fluid, promoting interaction of the components and improving combustion.Type: ApplicationFiled: October 10, 2007Publication date: April 16, 2009Inventors: Fernando Roberto Paz Briz, Fernando Roberto Paz Alcazar
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Publication number: 20090054222Abstract: Systems and methods for robotic transport are disclosed herein. In some embodiments, robotic systems for transporting biological samples include: a plurality of capillary vessels, in which each capillary vessel can contain a biological sample from a population; a receptacle that can contain the plurality of capillary vessels; a centrifuge; a first robotic device that can transport the receptacle between an input module and the centrifuge; a second robotic device that can transport the receptacle between the centrifuge and a sample harvest location; a cutting device that can cut each of the plurality of capillary vessels; a multi-well plate having a plurality of wells arranged in an array; and a third robotic device that can transfer at least one portion of each of the plurality of biological samples from each of the plurality of capillary vessels to a corresponding well in the array.Type: ApplicationFiled: August 24, 2007Publication date: February 26, 2009Inventors: Jian Zhang, Alessio Salerno, Nabil Simaan, Y. Lawrence Yao, Gerhard Randers-Pehrson, Guy Garty, Aparajita Dutta, David J. Brenner
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Publication number: 20080318755Abstract: According to an aspect of the present invention, there is provided a bio cell cleaning centrifuge including: a motor; a rotor rotated by the motor; holders that are equipped on the rotor and that hold test tubes to be pivotable toward a rotational radial direction of the rotor; a cleaning liquid distributor mounted on the rotor to supply a cleaning liquid to the test tubes; a locking mechanism that locks the holders so that the test tubes are in a vertical state with respect to the rotational radial direction; and a controller that controls the motor and the locking mechanism, wherein the holders are configured to hold the test tubes so that central axes thereof are inclined from a rotational axis direction toward a rotational tangent direction of the rotor.Type: ApplicationFiled: June 19, 2008Publication date: December 25, 2008Inventor: Kenji YAMADA
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Publication number: 20080164194Abstract: A centrifugal fraction collection system including a rotating carrier for holding at least one sample collection container and inducing a centrifugal force, a guide disposed on the rotating carrier, and a flexible eluant tube disposed over the rotating carrier and through the guide for receiving a flow of eluant having volatile and non-volatile components and directing the flow of eluant into at least one sample collection container wherein the centrifugal force separates the non-volatile and volatile components based on their respective densities and collects the non-volatile components in at least one sample collection container.Type: ApplicationFiled: September 19, 2007Publication date: July 10, 2008Inventor: Herbert J. Hedberg
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Patent number: 7396452Abstract: An apparatus comprises an inlet to convey a first fluid comprising first and second components having different density into a rotating chamber such that an interface forms between at least portions of such components at a first location. At least one outlet removes at least one of the first and second components. A controller is adapted to introduce the first fluid and is operable to move the interface from the first location to a second location and to move the interface from the second location in a direction toward the first location and to return the interface to the second location. The controller is operable to determine a flow rate of the first or second component based, at least in part, on the time interval between when the interface moves from and returns to the second location. At least one sensing assembly is adapted to sense the location of the interface.Type: GrantFiled: June 29, 2006Date of Patent: July 8, 2008Assignee: Fenwal, Inc.Inventors: Kyungyoon Min, Richard I. Brown
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Patent number: 7201848Abstract: The present invention is directed to a method and system that separates first particles from second particles, or white blood cells from red blood cells, by sedimentation in a fluid chamber with debulking of one of the first or second particles or red blood cells through the inlet of the fluid chamber. The method and system further includes fractionation of the remaining particles or white blood cells into selected subsets. In one embodiment of the instant invention a blood product containing white blood cells is loaded in a separation chamber, a diluting or sedimenting agent is added to encourage rouleaux formation of any red blood cells, the cells are sedimented and the red blood cells are removed.Type: GrantFiled: December 4, 2002Date of Patent: April 10, 2007Assignee: Gambro BCT, Inc.Inventors: Glen Delbert Antwiler, Linda A. Taylor
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Patent number: 6857997Abstract: A bio cell cleaning rotor assembled in a centrifuge. The rotor includes a plurality of test tube holders for holing a plurality of test tubes. The holders are pivotally movably supported to a rotor body so that the test tube holders are moved toward a horizontal direction upon application of centrifugal force. A cleaning liquid distributor is positioned above the rotor and is rotatable together with the rotor for distributing even amount of cleaning liquid to the plurality of test tubes. The distributor includes a disc like upper segment and a disc like lower segment in opposition thereto. The upper and lower distribution segments are molded products and have radially outer side flat sections in intimate contact with each other. A plurality of radial grooves are formed in at least one of the flat sections. The radial grooves serving as cleaning liquid distribution nozzles each having radially outer end open toward each opening of each test tube.Type: GrantFiled: March 13, 2003Date of Patent: February 22, 2005Assignee: Hitachi Koki Co., Ltd.Inventors: Kenji Yamada, Kazuhiko Murayama, Daijiro Shiraishi
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Patent number: 6846460Abstract: A simple, efficient apparatus and method for separating layers of immiscible or partially miscible liquids useful in methods of high-throughput combinatorial organic synthesis or parallel extraction of large libraries or megaarrays of organic compounds is disclosed. The apparatus and method are useful, whether as part of an automated, robotic or manual system for combinatorial organic synthesis or purification (extraction). In a preferred embodiment, an apparatus and method for separating layers of immiscible or partially miscible liquids compatible with microtiter plate type array(s) of reaction vessels is disclosed. Another application of centrifugation based liquid removal was found for washing the plates in biological assays or synthesis on modified substrates.Type: GrantFiled: January 28, 2000Date of Patent: January 25, 2005Assignee: Illumina, Inc.Inventor: Michal Lebl
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Patent number: 6846281Abstract: A bio cell cleaning centrifuge having a detachable inner chamber body. The centrifuge includes a rotor detachable from a drive mechanism. Test tube holders are pivotally movably supported on the rotor for holding test tubes. A cleaning liquid distributor is detachably disposed on the rotor for supplying cleaning liquid to the respective test tubes. A bowl detachable from the drive mechanism is disposed below the test tube holders. The inner chamber body is disposed below the bowl for receiving therein supernatant liquid discharged out of the test tubes during rotation of the rotor. The inner chamber body is detachably mounted on a main case. The inner chamber body is detached after the distributor, the rotor, and the bowl are detached.Type: GrantFiled: March 13, 2003Date of Patent: January 25, 2005Assignee: Hitachi Koki Co., Ltd.Inventors: Kazuhiko Murayama, Kenji Yamada, Daijiro Shiraishi
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Patent number: 6808633Abstract: A centrifugal separator of the invention has a centrifugal rotor (10-1), with symmetric rotation axes, having single sample separation chamber in it for centrifuging samples contained in sample solutions, an upper opening passing through to said sample separation chamber in the upper part, members of frameworks capable of being coupled to said upper opening, a rotation driving means, assuming that the direction of said symmetric rotation axis is the first direction, for driving said centrifugal rotor around said rotation axis in the first direction, wherein assuming that two directions intersecting with said first direction are the second and third directions, the length of said sample preparation chamber in said third direction is longer than the length of said sample preparation chamber in said second direction.Type: GrantFiled: December 20, 2001Date of Patent: October 26, 2004Assignee: Hitachi, Ltd.Inventors: Kazunori Okano, Katsuji Murakawa, Shinichi Fukuzono, Yukiko Ikeda
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Patent number: 6793828Abstract: A centrifugal method of separating and collecting components from a fluid is provided, comprising providing a centrifuge operable at a plurality of rotation speeds and having a mounting assembly for positioning and retaining a disposable collection assembly relative to the centrifuge at the rotation speeds; mounting a separation assembly comprising a number of collection chambers in the mounting assembly, wherein each of the collection chambers include an outer, conical-shaped collection portion with a port for providing a fluid pathway for the fluid into and out of the collection chambers and wherein the mounting includes fluidically connecting the ports with a fluid tube; connecting a fluid source to the fluid tube; rotating the centrifuge at a fill speed; and operating the fluid source to supply the fluid to the fluid tube, whereby the fluid is concurrently supplied in substantially equal volumetric and component density quantities to each of the collection chambers.Type: GrantFiled: May 8, 2003Date of Patent: September 21, 2004Assignee: Medtronic, Inc.Inventors: Victor D. Dolecek, David Malcolm, Kevin D. McIntosh
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Patent number: 6743632Abstract: Centrifugal analyzer and method for staining biological or non-biological samples in microgravity, wherein the method utilizes an increase in weight of a fluid sample as a function of g-load, to overcome cohesive and frictional forces from preventing its movement in a preselected direction. Apparatus is characterized by plural specimen reservoirs and channels in a slide, each channel being of differing cross-section, wherein respective samples are selectively dispensed, from the reservoirs in response to an imposed g-factor, precedent to sample staining. Within the method, one thus employs microscope slides which define channels, each being of a differing cross-section dimension relative to others. In combination therewith, centrifugal slide mounting apparatus controllably imposes g-vectors of differing magnitudes within a defined structure of the centrifuge such as a chip array.Type: GrantFiled: March 14, 2001Date of Patent: June 1, 2004Assignee: Universities Space Research AssociationInventors: Mark S. F. Clarke, Daniel L. Feeback
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Patent number: 6709378Abstract: Primaiy supernatant liquid collector 1 allows blood A to separate into a primary supernatant liquid B and red blood cells by leaving the blood A stationary for a prescribed period of time, and then it discharges the primary supernatant liquid B and physiological saline W in the same amount into a first treatment container 13 and a first balance container 14, respectively. Centrifuge 61 centrifuges the above primary supernatant liquid B using the first balance container 14 as a balance weight, and a secondary supernatant liquid in the first treatment container 13 is transferred to a second treatment container 109 by take-out device 91 and at the same time the physiological saline W in the same amount as the transferred secondary supernatant liquid is transferred from the first balance container 14 to a second balance container 110.Type: GrantFiled: April 1, 2002Date of Patent: March 23, 2004Assignees: Fujisawa Pharmaceutical Co., Ltd., Shibuya Kogyo Co., Ltd.Inventors: Shintaro Nishimura, Kazuyoshi Yajima, Satoshi Minoshima, Ichiro Matsunari, Hiroshi Myogan
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Patent number: 6689042Abstract: A centrifuge with an associated container system in the form of cassettes for separation and treatment of blood or blood components has been developed. The centrifuge includes a rotor having a central compartment in the form of a tubular shaft cavity extending concentrically with the axis of rotation of the rotor and an annular separation compartment which is arranged around the cavity at the upper part thereof. A first container system is arranged in the rotor, for washing of blood cells, includes a round bag and two or more flexible secondary containers connected thereto, one of which contains a treatment liquid and a tubular sleeve adapted to the shaft cavity of the rotor. The secondary containers are arranged in the sleeve to rest against each other and the round bag is mounted on a projecting flange at the upper part of the sleeve.Type: GrantFiled: January 22, 2002Date of Patent: February 10, 2004Assignee: Gambro, Inc.Inventors: Peter Unger, Eric Westberg
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Publication number: 20030232712Abstract: A centrifugal method, and corresponding system, for processing blood to collect platelet rich plasma. A separation chamber is filled with blood from a fill syringe by rotating the separation chamber at a fill rotation rate and pumping the blood from the fill syringe. A soft spin is used to initially separate red blood cells from platelets by spinning the separation chamber at a soft spin rate. A percentage of the blood is drawn from the separation chamber back into the fill syringe to remove separated red blood cells. A second portion of the separated blood is drawn from the separation chamber until a red blood cell/platelet interface is detected. A hard spin is performed by spinning the separation chamber at a higher rate and connecting tubing is cleared of red blood cells by drawing a predetermined clearing volume. The platelet rich plasma is then collected in the collection syringe.Type: ApplicationFiled: January 10, 2003Publication date: December 18, 2003Inventors: Victor D. Dolecek, Gary L. Berg, Kenneth E. Merte, David Malcolm, Kevin D. McIntosh, Vitaly G. Sitko
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Publication number: 20020142470Abstract: Centrifugal analyzer and method for staining biological or non-biological samples in microgravity, wherein the method utilizes an increase in weight of a fluid sample as a function of g-load, to overcome cohesive and frictional forces from preventing its movement in a preselected direction. Apparatus is characterized by plural specimen reservoirs and channels in a slide, each channel being of differing cross-section, wherein respective samples are selectively dispensed, from the reservoirs in response to an imposed g-factor, precedent to sample staining. Within the method, one thus employs microscope slides which define channels, each being of a differing cross-section dimension relative to others. In combination therewith, centrifugal slide mounting apparatus controllably imposes g-vectors of differing magnitudes within a defined structure of the centrifuge such as a chip array.Type: ApplicationFiled: March 14, 2001Publication date: October 3, 2002Inventors: Mark S.F. Clarke, Daniel L. Feeback
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Patent number: 5906570Abstract: An apparatus and method are disclosed for filtering or separating particles. The apparatus has a motor coupled to a centrifuge rotor rotatable about an axis of rotation. A fluid chamber rotates with the rotor. A substance is supplied to the inlet of the chamber. At least one of the motor and the substance supply are controlled to maintain a saturated fluidized bed of first particles within the fluid chamber while causing second particles to be retained in the chamber.Type: GrantFiled: August 4, 1997Date of Patent: May 25, 1999Assignee: Cobe Laboratories, Inc.Inventors: Robert Langley, Dennis Hlavinka, Linda A. Taylor, John C. Walker
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Patent number: 5885239Abstract: A rotor for collecting and centrifuging biological fluids in a range of volumes. The rotor includes an elastic impermeable diaphragm which defines at least a portion of a variable-volume processing chamber, where the fluid is centrifuged. The rotor includes a rigid mounting member, to which the diaphragm is mounted and which is held and spun by a chuck. Preferably, this rigid mounting member includes a boundary wall which together with the elastic diaphragm defines the chamber. The boundary wall may be a substantially imperforate circular wall which extends to the periphery of the processing chamber but defining one opening, preferably near the axis of rotation, permitting a conduit or conduits to pass therethrough so as to be in fluid communication with the processing chamber. The rotor may include a separate structure for controlling the flow of liquid out of the chamber into the conduit.Type: GrantFiled: February 12, 1997Date of Patent: March 23, 1999Assignee: Transfusion Technologies CorporationInventors: Thomas D. Headley, Edward T. Powers
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Patent number: 5674173Abstract: A fluid chamber and method are disclosed for filtering or separating particles. The fluid chamber includes a wall extending between an inlet and outlet to form a fluid chamber interior. The interior converges from a position of maximum cross-sectional area toward the inlet. A groove or a step may be formed on an inner surface of the fluid chamber wall to improve particle separation within the fluid chamber.Type: GrantFiled: April 18, 1995Date of Patent: October 7, 1997Assignee: Cobe Laboratories, Inc.Inventors: Dennis Hlavinka, Robert Langley, Linda Taylor, John C. Walker
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Patent number: 5610074Abstract: A centrifugal rotor effects the isolation, in a sequence of steps, of a substance from a mixture of substances dissolved, suspended or dispersed in a sample liquid. Multiple samples are processed simultaneously by means of a plurality of fractionation cells, each of which contains a series of interconnected, chambered and vented compartments in which individual steps of the fractionation and isolation procedure take place. Specific steps in the preferred embodiments include lysis, sedimentation, aggregation, sorption, rinsing, and desorption. The specific compartment occupied by the sample liquid or one of its fractions at any stage of the process is governed by the speed and direction of rotation of the rotor and by gravitational force. The interconnections, chambers and passages of each compartment are sized and angled to prevent predetermined amounts of sample and reagent liquids from overflowing the compartment.Type: GrantFiled: February 24, 1993Date of Patent: March 11, 1997Inventors: David R. Beritashvili, Maxim V. Myakishev, Gennady M. Ershov, George P. Georgiev, George I. Kapanadze
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Patent number: 5518930Abstract: The present invention provides centrifugal rotors for delivering a liquid, typically a biological sample such as diluted plasma, to a plurality of cuvettes in the rotor. The cuvettes are positioned radially inward of an annulate manifold and are connected to the manifold through a plurality of inlet channels. The liquid is introduced in one end of the manifold and, as the rotor spins, the liquid fills the manifold from the radially outward edge inward. After, the manifold fills, the liquid flows radially inward through the inlet channels into the chambers. The design allows the simultaneous filling of the cuvettes. The inlet channels may also be sized such that as liquid enters the cuvettes, gas escapes through the inlet channel.Type: GrantFiled: January 27, 1995Date of Patent: May 21, 1996Assignee: Abaxis, Inc.Inventor: Tammy L. Burd
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Patent number: 5409665Abstract: The present invention provides centrifugal rotors for delivering a liquid, typically a biological sample such as diluted plasma, to a plurality of cuvettes in the rotor. The cuvettes are positioned radially inward of an annulate manifold and are connected to the manifold through a plurality of inlet channels. The liquid is introduced in one end of the manifold and, as the rotor spins, the liquid fills the manifold from the radially outward edge inward. After, the manifold fills, the liquid flows radially inward through the inlet channels into the chambers. The design allows the simultaneous filling of the cuvettes. The inlet channels may also be sized such that as liquid enters the cuvettes, gas escapes through the inlet channel.Type: GrantFiled: September 1, 1993Date of Patent: April 25, 1995Assignee: Abaxis, Inc.Inventor: Tammy L. Burd
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Patent number: 5328440Abstract: A bucket for use in a swinging bucket centrifuge. A core holder is located between two end chambers, with the annular space between the core holder and the bucket sidewall maintaining the chambers in fluid communication. Windows at each end of the bucket allow fluid collections to be monitored. This enables more accurate data to be obtained regarding the effect of fluids of different specific gravity on a fluid saturating a sample. For example, to obtain data allowing a more accurate modeling of reservoir conditions in an oil field impacted by both gas and water displacement, the amount of oil expelled from a rock sample by gas under pressure and temperature conditions simulating those in the reservoir is measured and, after replacing the gas with water, the amount of oil expelled by water under simulated conditions is measured.Type: GrantFiled: June 9, 1993Date of Patent: July 12, 1994Assignee: Marathon Oil CompanyInventors: Hung-Lung Chen, Hiemi K. Haines, Sidney R. Smith
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Patent number: 5310527Abstract: A tube for use in a pelleting centrifuge rotor is characterized in first aspect by a first, acute, corner and a second, obtuse, corner defined in the lowermost pelleting region thereof. The corner defined by the acute angle lies a greater axial distance from the mouth of the tube than the corner defined by the obtuse angle. In a second aspect the tube the interior of the tube has a constricted region with a guide adjacent thereto. The guide channel is sized to accept a supernatant removal implement.Type: GrantFiled: December 14, 1992Date of Patent: May 10, 1994Assignee: E. I. Du Pont de Nemours and CompanyInventors: William A. Romanauskas, Hugh H. Tansey, III
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Patent number: 5242606Abstract: An analytical rotor for separating plasma whole blood comprises a rotor body having a sample application port in an upper surface thereof. Blood introduced to the sample application port is metered into a metering chamber by capillary flow while the rotor remains stationary. Excess blood passes into an overflow chamber by capillary flow, either simultaneously with the metered flow or after opening of a vent in the overflow chamber. Subsequent rotation of the rotor causes metered blood in the metering chamber to flow into a receiving chamber, typically a plasma separation chamber.Type: GrantFiled: October 29, 1991Date of Patent: September 7, 1993Assignee: Abaxis, IncorporatedInventors: Boris Braynin, Tammy L. Burd, Steven Buhl, Carol T. Schembri
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Patent number: 5215376Abstract: A test tube handling assembly has an elongate member with an end for engaging a test tube and an end opposite thereto driven about an axis of the member for orbital movement with its axis. The member is a slender rod with a spherical bearing about a center part thereon between the ends thereof and along its axis. An arm extends from a support to carry the spherical bearing and permit limited motion of the rod relative to the support. A gripping means on the end for engaging the test tube holds the test tube and its contents during movement of the rod relative to the axis. A drive located on the support near the end opposite causes the test tube to swing about the center part. Contacting means with a seal for closing the open end of the test tube is part of an inflatable bladder which holds the open end of the test tube by fitting in the open end of the test tube. The drive has a motor for providing orbital motion.Type: GrantFiled: March 9, 1992Date of Patent: June 1, 1993Assignee: Becton, Dickinson and CompanyInventors: Harvey Schulte, Sal Noto
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Patent number: 5178602Abstract: A centrifuge having an automatic dispensing rotor is employed for pelleting material and automatically decanting supernatant liquid by means of gravity drainage. The automatic decanting rotor employs a magnetically activated lock mechanism for locking swinging buckets in an elevated position while the rotor is at speed. When the rotor is brought to rest, the swinging buckets do not pivot to their rest position but are sustained in their elevated position by means of the magnetically activated lock. Liquids are automatically decanted from the swinging buckets when the rotor is brought to rest while the swinging buckets are sustained within their elevated position.Type: GrantFiled: September 9, 1991Date of Patent: January 12, 1993Inventor: John R. Wells
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Patent number: 5173262Abstract: A rotor assembly for performing a relatively large number of processing steps upon a sample, such as a whole blood sample, and a diluent, such as water, includes a rotor body for rotation about an axis and including a network of chambers within which various processing steps are performed upon the sample and diluent and passageways through which the sample and diluent are transferred. A transfer mechanism is movable through the rotor body by the influence of a magnetic field generated adjacent the transfer mechanism and movable along the rotor body, and the assembly utilizes centrifugal force, a transfer of momentum and capillary action to perform any of a number of processing steps such as separation, aliquoting, transference, washing, reagent addition and mixing of the sample and diluent within the rotor body. The rotor body is particularly suitable for automatic immunoassay analyses.Type: GrantFiled: May 30, 1989Date of Patent: December 22, 1992Assignee: Martin Marietta Energy Systems, Inc.Inventors: Carl A. Burtis, Wayne F. Johnson, William A. Walker
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Patent number: 5160702Abstract: An analyzer with an improved rotor structure for analyzing solid-containing and solid free liquids having an improved rotor design that utilizes chambers and channels that operate by centrifugal force and capillary action to separate and meter the liquids for testing purposes.Type: GrantFiled: January 17, 1989Date of Patent: November 3, 1992Assignee: Molecular Devices CorporationInventors: Anne R. Kopf-Sill, Robert Zuk
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Patent number: 5122284Abstract: A centrifugal rotor comprising a plurality of peripheral cuvettes and a collection chamber spaced radially inward from the cuvettes is disclosed. The rotor includes a means for introducing fluid into the collection chamber and plurality of generally radial inlet channels connecting each cuvette to the chamber. Each inlet channel has a discrete flow path for fluid to enter the cuvette and another discrete flow path for gas to exit the cuvette as the cuvette is filled. Positioned radially inward from each cuvette is a reflective surface capable of deflecting a light beam from a generally vertical direction to a generally horizontal direction or vice versa. As the rotor is spun, fluid enters the cuvettes from collection chamber through the inlet channels, which also allow gas in the cuvettes to escape, thus avoiding the creation of bubbles in the cuvette after the cuvettes are filled. The contents are then optically analyzed by passing a light beam horizontally through the cuvette.Type: GrantFiled: April 1, 1991Date of Patent: June 16, 1992Assignee: Abaxis, Inc.Inventors: Boris Braynin, Tammy L. Burd, Vladimir Ostoich
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Patent number: 5096573Abstract: An apparatus wherein a centrifuge organization includes a mounting ring, and includes a plurality of pairs of stirrups, each securing therewithin an associated container. Each container includes a color-coded lid and anhydrous gel cylindrical floor and an annular wall, including a coating of silicone in a powdered or gel form. Vacuum porting is provided through each lid of each container in cooperation with an intake conduit for directing blood and associated fluid into the container.Type: GrantFiled: March 21, 1991Date of Patent: March 17, 1992Inventor: Wilfred Bermudez
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Patent number: 5084133Abstract: The centrifugal evaporator-concentrator comprises a central tubular pivot (18) surmounted by a nozzle (35) and constituting the pivot axis of a rotor (9) rotating in a vessel (8) closed by a cover (11). With the rotor rotating in the partial vacuum created by a vacuum pump (33), a small quantity of gas or air is temporarily and periodically admitted into the vessel, this gas being heated by a heating resistor (38) inside the vessel for the purpose of heating by conduction the specimens to be concentrated and of accelerating the rate of evaporation.Type: GrantFiled: March 12, 1990Date of Patent: January 28, 1992Assignee: JouanInventors: Jean L. Guy, Michel Serveau
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Patent number: 5061381Abstract: A centrifugal rotor for separating plasma from whole blood includes a plurality of internal chambers and passages for combining the plasma with one or more reagents and distributing the plasma to a plurality of individual test wells. The chambers and passages necessary for separating the whole blood into plasma are located on a first, upper level within the rotor and include a measuring chamber, an overflow chamber, a separation chamber, and a reagent chamber. The measuring chamber and overflow chamber have capillary dimensions so that an initial volume of whole blood partitions therebetween, with the measuring chamber filling first to provide a preselected volume. The separation chamber is located radially outward from both the measuring chamber and the reagent chamber to that spinning of the rotor causes both the reagent and the measured blood volume to flow outward into the separation chamber.Type: GrantFiled: June 4, 1990Date of Patent: October 29, 1991Assignee: Abaxis, Inc.Inventor: Tammy L. Burd