Including Plurality Of Miniature Bowls (e.g., Test Tubes) Distrubuted About Rotatable Carrier And Readily Removable Therefrom Patents (Class 494/16)
  • Patent number: 10434522
    Abstract: A fixed angle centrifuge rotor includes a rotor body having a circumferential sidewall and a plurality of circumferentially spaced tubular cavities. Each tubular cavity has an open end and a closed end, and is configured to receive a sample container therein. The rotor further includes a pressure plate operatively coupled to the rotor body so that the pressure plate, in combination with the plurality of tubular cavities and the circumferential sidewall of the rotor body, define a hollow chamber within the rotor. The rotor further includes a plurality of elongated torque transfer members supported by the rotor body and an annular containment groove.
    Type: Grant
    Filed: March 14, 2019
    Date of Patent: October 8, 2019
    Assignee: Fiberlite Centrifuge, LLC
    Inventor: Sina Piramoon
  • Patent number: 10272446
    Abstract: A fixed angle centrifuge rotor includes a rotor body having a circumferential sidewall and a plurality of circumferentially spaced tubular cavities. Each tubular cavity has an open end and a closed end, and is configured to receive a sample container therein. The rotor further includes a pressure plate operatively coupled to the rotor body so that the pressure plate, in combination with the plurality of tubular cavities and the circumferential sidewall of the rotor body, define a hollow chamber within the rotor. The rotor further includes a plurality of elongated torque transfer members supported by the rotor body and an annular containment groove.
    Type: Grant
    Filed: August 27, 2018
    Date of Patent: April 30, 2019
    Assignee: Fiberlite Centrifuge, LLC
    Inventor: Sina Piramoon
  • Patent number: 10086383
    Abstract: A fixed angle centrifuge rotor includes a rotor body having a circumferential sidewall and a plurality of circumferentially spaced tubular cavities. An annular containment groove is disposed above and circumferentially surrounds the tubular cavities. Each tubular cavity has an open end and a closed end, and is configured to receive a sample container therein. The rotor further includes a pressure plate operatively coupled to the rotor body so that the pressure plate, in combination with the plurality of tubular cavities and the circumferential sidewall of the rotor body, define a hollow chamber within the rotor. The pressure plate includes circumferentially spaced upstanding tabs that are received in respective pockets located between adjacent tubular cavities. The rotor further includes a plurality of elongated torque transfer members supported by the rotor body.
    Type: Grant
    Filed: January 5, 2015
    Date of Patent: October 2, 2018
    Assignee: Fiberlite Centrifuge, LLC
    Inventor: Sina Piramoon
  • Patent number: 9556412
    Abstract: An example includes an apparatus for separating cells from a fluid sample, including a plenum, defining: a centrally located top inlet, and respective side outlets disposed below the inlet and to the side of the inlet; and a bottom outlet disposed below the top inlet, to the side of the two or more outlets, wherein the plenum is configured to receive a fluid and cells suspension through the inlet, and direct it to the bottom outlet, against respective side-walls extending between the bottom outlet and the two or more side outlets, and wherein the distance between each of the two or more side outlets and the bottom outlet is selected to encourage cells to exit through the bottom outlet under a force. Lateral/vertical distance between the inlet and side outlets can provide lateral fluid travel, thereby allowing time for gravity to bias cells toward an outlet.
    Type: Grant
    Filed: April 17, 2013
    Date of Patent: January 31, 2017
    Assignee: Regents of the University of Minnesota
    Inventors: Allison Hubel, Jacob Hanna
  • Patent number: 9260763
    Abstract: An automated process for converting samples includes: receiving tube strips having a number of sample tubes and samples therein, transferring multiple tube strips to a tube strip holder, dispensing sample conversion buffer into each tube, shaking the tube strip holder a first time, centrifuging the tube strip holder, removing a liquid supernatant from each tube, simultaneously inspecting the contents of each tube, dispensing a specimen transport medium and a denaturation reagent into each tube, shaking the tube strip holder a second time, heating the tube strip holder for a first length of time, shaking the tube strip holder a third time, heating the tube strip holder for a second length of time, shaking the tube strip holder a fourth time, and transferring at least a portion of each sample to a respective well on an output plate.
    Type: Grant
    Filed: October 22, 2012
    Date of Patent: February 16, 2016
    Assignee: Qiagen Gaithersburg, Inc.
    Inventors: Bradley Scott Thomas, Suganthi Ramachandran, Jason Troxell, Bowen Cui, Carl Theodore Edens, Andrew Leonard, Bert Jungheim
  • Patent number: 9114407
    Abstract: A rotor includes a plurality of holding cavities for holding specimen containers, respectively. A transverse cross sectional shape of the holding cavity is a substantially triangular shape having one vertex on an inner circumference side of the rotor. Two vertices of the substantially triangular shape are arranged on an outer circumference side of the rotor so as to have equidistance from a rotary shaft of the rotor. Spacing between sides of the substantially triangular shape in a circumferential direction of the rotor gradually increase over 60% or more a radial length of the holding cavity from an innermost circumferential position to the outer circumference side of the rotor when viewed in its transverse plane.
    Type: Grant
    Filed: June 30, 2010
    Date of Patent: August 25, 2015
    Assignee: HITACHI KOKI CO., LTD.
    Inventors: Yoshimitsu Kitazawa, Masaharu Aizawa, Kenichi Nemoto, Jun Sato
  • Patent number: 9039992
    Abstract: A centrifuge to which sample tubes can be introduced while the centrifuge is in motion. The centrifuge comprises a carousel having an upper portion and a lower portion. The upper portion of the carousel has a plurality of positions for sample tubes for a centrifugation operation, a plurality of drive mechanisms attached to the upper portion of the carousel, a movable element mounted upon each drive mechanism, the movable element capable of traversing the length of the drive mechanism when the drive mechanism is actuated, a sample tube-holding assembly comprising a sample tube holder and a bearing attached to each movable element, and at least one balancing element capable of contributing to a force vector that cancels an imbalance vector generated by rotation of the centrifuge.
    Type: Grant
    Filed: June 6, 2011
    Date of Patent: May 26, 2015
    Assignee: ABBOTT LABORATORIES
    Inventor: Patrick P. Fritchie
  • Publication number: 20150141233
    Abstract: The invention relates to an adapter for a centrifuge vessel having a shell-shaped base body formed as one piece and delimiting a cavity for the purpose of accommodating the centrifuge vessel and comprising a base region and an adjacent side-wall region of which the top edge defines the opening edge of the cavity, at least one expansion joint being present in the side-wall region, which expansion joint when subjected to a force allows for moving the side-wall region from a starting position to an expanded position such that the length of the opening edge is greater in the expanded position than in the starting position. The adapter is made of a plastics material such that when the force is removed from the side-wall region the base body automatically returns to the starting position.
    Type: Application
    Filed: July 8, 2013
    Publication date: May 21, 2015
    Inventor: Norman Ballhause
  • Publication number: 20150141232
    Abstract: A centrifuge for high-speed centrifuging, includes: a shaft, mounted for continuous rotation about its axis, the shaft having a working section having a loading end and an unloading end; an acceleration member mounted adjacent to the loading end for rotation with respect to the shaft and; a deceleration member mounted adjacent to the unloading end for rotation with respect to the shaft; auxiliary drive arrangement for accelerating the acceleration member and the deceleration member to the shaft speed; carriages for supporting specimens for centrifugation. The carriages are slideably mounted for traversing from the acceleration member to the working section and from the working section to the deceleration member. A carriage may be accelerated on the acceleration member and then transferred to the working section for a period sufficient to perform centrifuging and then transferred from the working section to the deceleration member.
    Type: Application
    Filed: May 21, 2013
    Publication date: May 21, 2015
    Inventor: Willen Marius VERWEIJ
  • Publication number: 20150114123
    Abstract: A gripper unit for handling a vessel for receiving biological material is proposed, inter alia. The vessel has a lid which can assume an open position and a closed position. The gripper unit comprises a gripper for gripping and releasing the vessel, and a lid holder, for holding a lid in a defined position in relation to the vessel. The defined position is an open position of the lid.
    Type: Application
    Filed: November 24, 2014
    Publication date: April 30, 2015
    Inventors: Andreas SCHAEFER, Thomas VOIT, Walter TSCHOPP, Adrian GEIGER, Markus ZBINDEN, Harald HIBBING, Andreas KARL, Frank EIGEMEIER, Volker BEHRMANN, Dietmar KOPP, Andreas SCHMIEDE
  • Publication number: 20150094196
    Abstract: A revolver component for a reagent vessel has at least one first chamber that is configured to be filled at least partly with at least one liquid. The first chamber is formed or fitted such that a first chamber filling volume that is configured to be filled with the at least one liquid is delimited by an expansion-variable boundary. The expansion-variable boundary has a spatial expansion that can be reversibly adjusted such that the filling volume is configured to be varied. Reagent vessel insert parts and reagent vessels are also disclosed. Methods for centrifuging a material and for pressure treating a material are also disclosed.
    Type: Application
    Filed: February 21, 2013
    Publication date: April 2, 2015
    Inventors: Martina Daub, Guenter Roth, Arne Kloke, Nils Paust, Juergen Steigert, Felix von Stetten
  • Patent number: 8986185
    Abstract: A hand-cranked centrifuge is adapted for use in isolating autologous fat in injectible from. A number of syringes are hingeably coupled to a flywheel of the centrifuge. As the centrifuge turns, the syringe(s), which are supported at one end, move into a horizontal orientation and are centrifuged until the fats get separated from other liquids present in the syringes. A number of syringes, syringe holders and related devices are disclosed to accommodate centrifugation.
    Type: Grant
    Filed: September 24, 2010
    Date of Patent: March 24, 2015
    Assignee: Lipovera, LLC
    Inventor: Daniel A. Del Vecchio
  • Patent number: 8950586
    Abstract: A platelet collection device comprising a centrifugal spin-separator container with a cavity having a longitudinal inner surface. A float in the cavity has a base, a platelet collection surface above the base, an outer surface. The float density is below the density of erythrocytes and above the density of plasma. The platelet collection surface has a position on the float which places it below the level of platelets when the float is suspended in separated blood. During centrifugation, a layer of platelets or buffy coat collects closely adjacent the platelet collection surface. Movement of a float having a density greater than whole blood through the sedimenting erythrocytes releases entrapped platelets, increasing the platelet yield.
    Type: Grant
    Filed: July 1, 2013
    Date of Patent: February 10, 2015
    Assignee: Hanuman LLC
    Inventors: Randel Dorian, Richard W. Storrs, Scott R. King
  • Patent number: 8951180
    Abstract: The invention refers to a centrifuge for separating whole blood into its blood components and a method for extracting a highly enriched thrombocyte concentrate out of whole blood. For this purpose, the centrifuge comprises a closed loop and/or open-loop control unit as well as a drive unit coupled to the closed loop and/or open-loop control unit, a rotor (12) having at least two container receptacles (14a, 14b; 16a, 16) for removably holding containers (18, 20, 22, 24) being in fluid communication with each other, at least one sensor arranged between the container receptacles (14a, 14b; 16a, 16b) and coupled with the closed loop and/or open-loop control unit for detecting a separation layer. Herein, a motor/gear unit (30a, 30b, 32a, 32b) coupled to the closed loop and/or open-loop control unit is associated with each of the container receptacles (14a, 14b; 16a, 16b).
    Type: Grant
    Filed: September 3, 2010
    Date of Patent: February 10, 2015
    Assignee: Andreas Hettich GmbH & Co. KG
    Inventor: Klaus-Günter Eberle
  • Publication number: 20150031521
    Abstract: The invention relates to a sample carrier centrifuge for a sample carrier (24) that has at least one sample channel (26) extending along an essentially central sample channel longitudinal axis (P), having a sample carrier receptacle (14), which can be rotated around a rotation axis (R) and has a holding section (38) into which the sample carrier (24) can be inserted in a loading procedure when the sample carrier receptacle (14) is not rotating, in which section the sample carrier (24) is held in the loaded state of the sample carrier receptacle (14), and from which section the sample carrier (24) can be removed in an unloading procedure, which is characterized in that a platform (22) of the sample carrier centrifuge (10), which is embodied for supporting the sample carrier centrifuge (10) in accordance with its designated use, is oriented parallel to the rotation axis (R).
    Type: Application
    Filed: February 6, 2013
    Publication date: January 29, 2015
    Inventors: Zhaoqiang Wang, Friedrich Neuhäusser-Wespy
  • Patent number: 8932542
    Abstract: A gripper unit for handling a vessel for receiving biological material is proposed, inter alia. The vessel has a lid which can assume an open position and a closed position. The gripper unit comprises a gripper for gripping and releasing the vessel, and a lid holder, for holding a lid in a defined position in relation to the vessel. The defined position is an open position of the lid.
    Type: Grant
    Filed: September 26, 2006
    Date of Patent: January 13, 2015
    Assignee: Qiagen GmbH
    Inventors: Andreas Schaefer, Thomas Voit, Walter Tschopp, Adrian Geiger, Markus Zbinden, Harald Hibbing, Andreas Karl, Frank Eigemeier, Volker Behrmann, Dietmar Kopp, Andreas Schmiede
  • Publication number: 20140357465
    Abstract: Systems and methods are provided for processing blood or a fluid containing blood plasma and platelets. The blood or fluid is continuously added into a fluid separation chamber, which is used to isolate platelet-rich plasma therein. At least a portion of the platelet-rich plasma is automatically transferred from the fluid separation chamber into an injection device, with the fluid separation chamber and the injection device comprising components of a disposable flow circuit, which may be a closed system. One or more injection devices may be connected to a collection container or a pump device of the disposable flow circuit.
    Type: Application
    Filed: May 31, 2013
    Publication date: December 4, 2014
    Inventors: John W. Barry, JR., Brian C. Case, Jonathan Prendergast, Lan T. Nguyen, John Foley
  • Patent number: 8852070
    Abstract: A locking system for axially securing a rotor onto a rotatably mounted shaft. The arrangement includes a plurality of locking levers which are each pivotably mounted about axes extending perpendicularly to the shaft between a locking position and an unlocking position in planes containing the axes. The locking levers can each be automatically transferred between an unlocking position and a locking position depending on rotational speed. The locking levers are mounted on the rotor and an annular groove is provided on the shaft and engages with the locking levers in the locking position, wherein the locking levers are prestressed in the unlocking position. Advantageously, the rotor can be both installed and removed without tools by merely placing the rotor onto or removing the rotor from the shaft, in each case depending on rotational speed.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: October 7, 2014
    Assignee: Sigma Laborzentrifugen GmbH
    Inventor: Benjamin Peters
  • Patent number: 8840838
    Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.
    Type: Grant
    Filed: September 26, 2011
    Date of Patent: September 23, 2014
    Assignee: Theranos, Inc.
    Inventors: Elizabeth Holmes, John Kent Frankovich
  • Patent number: 8808551
    Abstract: An apparatus that allows for separating and collecting a fraction of a sample. The apparatus, when used with a centrifuge, allows for the creation of at least three fractions in the apparatus. It also provides for a new method of extracting the buffy coat phase from a whole blood sample and mesenchymal stem cells from bone reaming material. A buoy system that may include a first buoy portion and a second buoy member operably interconnected may be used to form at least three fractions from a sample during a substantially single centrifugation process. Therefore, the separation of various fractions may be substantially quick and efficient.
    Type: Grant
    Filed: November 15, 2010
    Date of Patent: August 19, 2014
    Assignee: Biomet Biologics, LLC
    Inventors: Michael D. Leach, Joel C. Higgins, Matthew Swift, Nathan Gordon
  • Publication number: 20140206521
    Abstract: A centrifugal separating assembly for separating a fluid biological product into discrete components by centrifugation is disclosed. The assembly includes a first container defining a first cavity adapted to receive a human biological product, the first container having a circular upper wall, a cylindrical sidewall, and a concave shaped bottom wall. The assembly further includes a second container defining a second cavity adapted to receive discrete components, the second container having a convex shaped upper wall, a second cylindrical wall, and a circular bottom wall; and a tubular conduit providing fluid communication between the first cavity and the second cavity.
    Type: Application
    Filed: January 21, 2014
    Publication date: July 24, 2014
    Inventor: Ziad Hamandi
  • Patent number: 8771614
    Abstract: The present invention relates to improved methods for processing fluids and to a fluid processing device (1) for use in a centrifuge comprising: (a) a first holder (14) form-fit to the shape of a first tube (18) for holding said first tube (18) whereby said first tube (18) has a first cross section (A1); and (b) a second holder (22) form-fit to the shape of a second tube (26) for holding said second tube (26) whereby said second tube (26) has a second cross section (A2) that is different from said first cross section (A1). With the fluid processing devices and the methods according to the invention, it is possible to simplify the centrifugal processing steps for a given fluid processing sequence and to automate them.
    Type: Grant
    Filed: September 26, 2006
    Date of Patent: July 8, 2014
    Assignee: Qiagen GmbH
    Inventors: Andreas Schaefer, Thomas Voit, Markus Zbinden, Andreas Schmiede
  • Publication number: 20140179505
    Abstract: The present invention relates to a centrifuge insert for sample holders and to a carrier for a centrifuge insert for sample holders. The centrifuge insert according to the invention has substantial advantages over known centrifuge inserts. These advantages are not limited to the fact that the carrier is attachable and detachable in a particularly easy and comfortable manner. It is also feasible to use different carriers for different sample holders. Furthermore, the centrifuge insert according to the invention is configured particularly light and compact so that the loading of the rotor is significantly lower for identical centrifugation powers or so that significantly higher RCA values can be used.
    Type: Application
    Filed: September 3, 2013
    Publication date: June 26, 2014
    Applicant: Eppendorf AG
    Inventors: Sandra David, Sylke Grune
  • Publication number: 20140100102
    Abstract: Methods and devices for molecular analysis are disclosed, based on centrifugation. A centrifuge device comprises strips of centrifuge tubes and elements to create a magnetic field. The magnetic shear forces applied to beads inside a solution with biological molecules permit the performance of different analytic techniques, such as lysis and sample preparation for PCR.
    Type: Application
    Filed: October 8, 2013
    Publication date: April 10, 2014
    Applicant: California Institute Of Technology
    Inventors: Aditya RAJAGOPAL, Emil P. KARTALOV, Carl J. ALLENDORPH, Axel SCHERER, Samson CHEN
  • Patent number: 8678987
    Abstract: The invention relates to a centrifuge with a drive head which can be connected with a drive, a rotor which can detachably be mounted on the drive head, at least one connection element with which the drive head can be connected in a torsion-proof manner with the rotor, and at least one coupling element which is attached to the drive head and is able to exert an axial force on the rotor in such a way that the rotor can be fixed axially, with the axial force increasing with the rising rotational speed of the drive head, with the coupling element on the rotor transmitting the axial force by means of a ramp surface which is inclined at an angle (?) relative to the horizontal line in a range of more than 0° to 15°. Secure locking of the rotor during standstill and high speeds can thus be achieved.
    Type: Grant
    Filed: September 3, 2009
    Date of Patent: March 25, 2014
    Assignee: Thermo Electron LED GmbH
    Inventor: Sebastian Henne
  • Publication number: 20140045670
    Abstract: An automated centrifuge apparatus for conducting a cell preparation procedure is provided. A rotor assembly supports centrifuge tubes, which are installable at respective tube positions. The tube positions are indexable to an index location. A sensing module monitors the index location during a set of status checks, which relate to the centrifuge tubes. Logic signals generated by the sensing module are used to automatically determine whether the status checks are satisfied.
    Type: Application
    Filed: August 7, 2012
    Publication date: February 13, 2014
    Applicant: MOLECULAR DEVICES, LLC
    Inventors: Thomas L. Smith, Bryan Wade, Edward Verdonk
  • Patent number: 8641968
    Abstract: A chemical analyzer, a method for sample-based analysis, a device for handling cuvette assemblies including a rotatable incubator with at least one curved opening for receiving a new cuvette assembly, an analyzer arranged around the incubator for analyzing contents of the new cuvette assembly, and a loading device adapted to carry the new cuvette assembly while initially being aligned in a straight manner before being loaded. The loading device includes a feed funnel having a first end for receiving the new cuvette assembly initially aligned in the straight manner into the feed funnel, and a second end for feeding the new cuvette assembly into the at least one curved opening, the second end having a curvature which corresponds to the curvature of the curved opening, the second end for bending the initially straight new cuvette assembly and fitting the new cuvette assembly into the at least one curved opening.
    Type: Grant
    Filed: May 27, 2009
    Date of Patent: February 4, 2014
    Assignee: Thermo Fisher Scientific Oy
    Inventors: Vesa Nuotio, Ville Saarainen, Juha Savonsalmi
  • Patent number: 8617041
    Abstract: Illustrative embodiments of automated sample workcells and methods of operation are disclosed.
    Type: Grant
    Filed: March 31, 2011
    Date of Patent: December 31, 2013
    Assignee: Roche Diagnostics Operations, Inc.
    Inventor: Joerg Haechler
  • Publication number: 20130324388
    Abstract: The present invention relates to a method and device for separating and transferring container (1) contents by dynamical use of centrifuge force, transferring a specific volume of liquid (A) from a recipient (1) to another (2) without contact with any external element other than the initial container (1) itself. Therefore, the present invention is useful for transferring for example part of a blood sample (A) from a tube (1) without touching the blood sample, also dispensing with a disposable needle as is currently usual. The invention is also advantageous as it allows keeping in the original container (1) a predetermined portion of the sample (B). By rotating the container, with a sufficiently high speed, over an axis (x) located at the boundary of the parts (A, B), the sample is split at a predetermined position. A preferred embodiment comprises the container at an angle (V) to the rotation axis (x).
    Type: Application
    Filed: December 9, 2010
    Publication date: December 5, 2013
    Applicant: ISENS - ELECTRONICA, LDA.
    Inventor: Pedro Ernesto Goncalves Guedes
  • Patent number: 8591391
    Abstract: A separation system for separating a multiple component material into at least two fractions. The separation system includes a separation device having a first end, a second end opposite to the first end, and a sidewall that extends between the first end and the second end to define a separation chamber having an interior volume. The system also includes a valve moveable between an open position and a closed position, the valve is mounted at a fixed location within the separation chamber at a position that is closer to the second end than to the first end and is spaced apart from the second end, the valve is operable to isolate a first fraction of the multiple component material having a first density on a first side of the valve from a second fraction having a second density on a second side of the valve that is opposite to the first side.
    Type: Grant
    Filed: April 12, 2010
    Date of Patent: November 26, 2013
    Assignee: Biomet Biologics, LLC
    Inventors: Jason Chavarria, Michael D. Leach
  • Publication number: 20130265417
    Abstract: A centrifuge is provided. The centrifuge includes a power source, the power source configured to generate electrical power from a renewable power source. At least one battery electrically coupled to the power source. A motor is electrically coupled to the at least one battery. A rotor is coupled to the motor. The rotor has a generally cylindrical body and a pair of opposing openings opposite the motor, and a pair of holders each disposed in one of the pair of opposing openings, each of the holders having an opening on one end sized to receive a capillary tube.
    Type: Application
    Filed: April 8, 2013
    Publication date: October 10, 2013
    Inventors: Michael Rust, Joseph T. Papu, Andrew W. Browne
  • Publication number: 20130190161
    Abstract: Centrifuges have been designed in the past for centrifuging multi-welled containers, but they are limited in centripetal acceleration or have a large footprint. The invention provides a centrifuge with a high centripetal acceleration and imbalance tolerance while maintaining a small footprint and being able to integrate with laboratory automation equipment. Methods and apparatuses for centrifugation include a rotor assembly positioned within a shield assembly suspended in a centrifuge. The rotor assembly is operably connected to the motor for rotating payloads (e.g., multi-welled containers) around an axis. The shield assembly is positioned such that the center of mass is aligned with the axis of rotation of the rotor assembly and the plane containing the rotational imbalance force vector. This alignment allows rotation of the container with an acceleration of at least 2000 g (or at least 3000 g, 4000 g, 5000 g, etc.).
    Type: Application
    Filed: January 24, 2013
    Publication date: July 25, 2013
    Applicant: BioNex Solutions, Inc.
    Inventor: BioNex Solutions, Inc.
  • Patent number: 8474630
    Abstract: A platelet collection device comprising a centrifugal spin-separator container with a cavity having a longitudinal inner surface. A float in the cavity has a base, a platelet collection surface above the base, an outer surface. The float density is below the density of erythrocytes and above the density of plasma. The platelet collection surface has a position on the float which places it below the level of platelets when the float is suspended in separated blood. During centrifugation, a layer of platelets or buffy coat collects closely adjacent the platelet collection surface. Movement of a float having a density greater than whole blood through the sedimenting erythrocytes releases entrapped platelets, increasing the platelet yield.
    Type: Grant
    Filed: May 25, 2012
    Date of Patent: July 2, 2013
    Assignee: Hanuman, LLC
    Inventors: Randel Dorian, Scott R. King, Richard Wood Storrs
  • Patent number: 8469202
    Abstract: A centrifugal processing bag, system and method for separating the components of a mixed material is presented. The processing bag includes a hub and a first port for receiving the mixed material, where the first port includes an outlet positioned within the processing bag at a perimeter of the bag. The processing bag also including a second port having a second port inlet spaced proximate the hub and away from a central axis of the hub. The second port directs a separated material collected from the second port inlet out of the processing bag.
    Type: Grant
    Filed: November 1, 2010
    Date of Patent: June 25, 2013
    Assignee: Velico Medical, Inc.
    Inventor: Keith M. Rosiello
  • Patent number: 8444934
    Abstract: A microfluidic flow cell for removably interfacing with a removable-member for performing a reaction therebetween. The microfluidic flow cell device comprises at least one reaction portion defining with the removable-member a reaction chamber when in an interfaced position thereof. The microfluidic flow cell comprises at least one fluid-receiving portion for receiving a fluid therein and being in fluid communication with the reaction chamber. When the microfluidic flow cell and the removable-member are in the interfaced position, the cell is adapted to allow for the fluid in the fluid-receiving portion to flow to the reaction chamber. Devices, systems and methods comprising this microfluidic flow cell are also disclosed.
    Type: Grant
    Filed: March 29, 2005
    Date of Patent: May 21, 2013
    Assignee: Universite Laval
    Inventor: Regis Peytavi
  • Patent number: 8414466
    Abstract: A centrifuge rotor cover has a lid, a circular plate attached to the lid with click holes formed in a circle, a knob and knob shaft, a plate spring attached to a surface of the knob facing the circular plate and an elastic body pushing the lid against the rotor depending on the distance between the knob and the lid. If this distance is equal to or less than a predetermined value, the plate spring is caught repeatably in the click holes as the knob is turned to cause sounds and vibrations that indicate the knob is not tightened securely.
    Type: Grant
    Filed: April 8, 2010
    Date of Patent: April 9, 2013
    Assignee: Kubota Manufacturing Corporation
    Inventor: Toshiharu Hashimoto
  • Publication number: 20130078149
    Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.
    Type: Application
    Filed: September 26, 2011
    Publication date: March 28, 2013
    Applicant: Theranos, Inc., a Delaware Corporation
    Inventors: Elizabeth Holmes, John Kent Frankovich
  • Patent number: 8377395
    Abstract: A blood specimen processor by means of which blood specimens are collected into a collection tube containing an anticoagulant and a molded buoy of predetermined density between 1.045 and 1.084 with an embedded water swellable o-ring that expands to form a robust seal in a leucocyte density gradient between the buoy's outer surface and tube's inner surface. The buoy is made of a first resin and a second resin, the first resin having a lower density than the second resin, the first resin and the second resin being present in such amounts and relative proportions so that the body has an overall density between 1.045 and 1.084 and preferably, a center of gravity below a geometric center of the body. When the blood specimen contained in the processor is centrifuged, the buoy is thrust through the separating blood and the developing interface of erythrocytes, leucocytes, and plasma.
    Type: Grant
    Filed: April 29, 2011
    Date of Patent: February 19, 2013
    Inventor: Charles M. Coleman
  • Patent number: 8336718
    Abstract: The present invention provides a centrifugal separation-use device capable of maintaining a centrifugal separation-use container in a clean state easily at low cost even when centrifugal separation treatment is carried out using a centrifugal separator in an unclean field. A centrifugal separation-use device 1 for collecting a target component by subjecting a solution containing multiple components to centrifugal separation treatment comprises an inner container 10 having a cylindrical section 12 for accommodating the solution and a plug 14 for hermetically sealing the cylindrical section and configured so as to accommodate the solution in a hermetically sealed state, and an outer container 20 having a support section 22 for removably accommodating the cylindrical section and a delivery section 24 for exposing part of the inner container so that the inner container can be removed, and configured so as to accommodate the inner container in a hermetically sealed state.
    Type: Grant
    Filed: March 11, 2008
    Date of Patent: December 25, 2012
    Assignee: Kyocera Medical Corporation
    Inventors: Noriyuki Shintani, Shuji Nosaka, Michihiro Yokokawa
  • Patent number: 8328024
    Abstract: A separator that uses centrifugation to fractionate a suspension such as blood comprises a separation container and a buoy. The buoy is carried in the separation container and has a tuned density that is configured to reach an equilibrium position in a suspension. The guide surface is carried on the buoy upper surface and is inclined to an accumulation position near a buoy perimeter. The buoy suspension fractionation system can be used in a method of isolating a fraction from a suspension, and in a method for re-suspending particulates for withdrawal.
    Type: Grant
    Filed: August 4, 2011
    Date of Patent: December 11, 2012
    Assignees: Hanuman, LLC, Biomet Biologics, LLC
    Inventors: Michael D. Leach, Randel Dorian, Jacy C. Hoeppner
  • Publication number: 20120309636
    Abstract: The present invention provides systems, devices, and methods for point-of-care and/or distributed testing services. The methods and devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device can be modified to allow for more flexible and robust use with the disclosed methods for a variety of medical, laboratory, and other applications. The systems, devices, and methods of the present invention can allow for effective use of samples by improved sample preparation and analysis.
    Type: Application
    Filed: January 20, 2012
    Publication date: December 6, 2012
    Inventors: Ian Gibbons, Anthony J. Nugent, Anthony Delacruz, Daniel Young, Elizabeth Holmes, Andrew Drake, Timothy Michael Kemp, Sunny Balwani, Chinmay Pangarkar
  • Patent number: 8323169
    Abstract: A fixed angle centrifuge rotor is provided. The rotor includes a rotor body having a circumferential sidewall and a plurality of tubular cavities. Each of the cavities has an open end and a closed end and is configured to receive a sample container therein. A pressure plate is operatively coupled to the plurality of tubular cavities so that the pressure plate, in combination with the plurality of tubular cavities, defines an enclosed hollow chamber between each adjacent pair of the plurality of tubular cavities. Each of the plurality of tubular cavities has a sidewall facing an interior of the rotor body and a bottom wall at the closed end.
    Type: Grant
    Filed: November 11, 2009
    Date of Patent: December 4, 2012
    Assignee: Fiberlite Centrifuge, LLC
    Inventor: Sina Piramoon
  • Patent number: 8236258
    Abstract: A method and apparatus can separate and concentrate a selected component from a multi-component material. The multi-component material may include a whole sample such as adipose tissue, whole blood, or the like. The apparatus generally includes a moveable piston positioned within a separation container and a withdrawal tube that is operable to interact with a distal end of the collection container past the piston. Material can be withdrawn through the withdrawal tube.
    Type: Grant
    Filed: October 31, 2011
    Date of Patent: August 7, 2012
    Assignee: Biomet Biologics, LLC
    Inventors: Michael D. Leach, James M. McKale
  • Patent number: 8226536
    Abstract: High-throughput centrifugation of batches of samples is achieved by dividing a single centrifugation run of a batch of samples into two or more staggered, discrete spins with fewer samples and in which the availability of centrifuge slots for loading or unloading of samples and the subsequent delivery of experimental results can be enhanced. The methodology is particularly useful in situations where multiple samples need to be processed rapidly, for example, as part of a STAT blood typing program in urgent care facilities prior to blood transfusion.
    Type: Grant
    Filed: December 12, 2011
    Date of Patent: July 24, 2012
    Assignee: Ortho-Clinical Diagnostics, Inc.
    Inventors: Michael L. Dee, Donald J. Moran, Jr., Mark Sawczuk, William G. Atterbury, Michael L. Marshall, Douglas E. Boyd
  • Patent number: 8221300
    Abstract: A centrifuge having two arcuate slots to receive resilient, bendable mounting flanges that each carry a plurality of test tubes in side by side relation. The resilience of the mounting flanges enables them to flex and assume either the curvature of the slot, or a linear configuration enabling the flanges to be suspended in a flat condition, such as on a test rack. The arrays of test tubes is attached to the flanges via living hinges that enable the flexing to occur. The advantages are that simplified identification of individual test tubes, as well as reduced likelihood of intermixing of spillage are realized.
    Type: Grant
    Filed: July 22, 2010
    Date of Patent: July 17, 2012
    Inventors: Yury Sherman, Michael Sherman, Ian Glasgow
  • Publication number: 20120156177
    Abstract: Methods and devices are disclosed for repairing injured, infected, or otherwise damaged connective tissues. Such repairs use injectable combinations of: (i) stromal precursor cells, which can be obtained from a patient via liposuction, and which can mature rapidly into muscle, ligament, tendon, or other types of connective tissue cells that are needed at a repair site; and (ii) platelets, which will accelerate and promote a repair process, and which can be obtained from the patient's blood. When mixed together, stromal precursor cells and platelet cells will act synergistically, to generate new tissue which can replace or repair damaged tissue. Devices and methods are disclosed for processing an already-centrifuged layer of “spun fat”, obtained from a liposuction extract, to remove unhelpful materials and concentrate the stromal precursor cells, before the stromal cells are mixed with platelet cells for injection into a patient.
    Type: Application
    Filed: October 7, 2011
    Publication date: June 21, 2012
    Inventor: MICHAEL A. SCARPONE
  • Patent number: 8187477
    Abstract: A platelet collection device comprising a centrifugal spin-separator container with a cavity having a longitudinal inner surface. A float in the cavity has a base, a platelet collection surface above the base, an outer surface. The float density is below the density of erythrocytes and above the density of plasma. The platelet collection surface has a position on the float which places it below the level of platelets when the float is suspended in separated blood. During centrifugation, a layer of platelets or buffy coat collects closely adjacent the platelet collection surface. Movement of a float having a density greater than whole blood through the sedimenting erythrocytes releases entrapped platelets, increasing the platelet yield.
    Type: Grant
    Filed: November 22, 2010
    Date of Patent: May 29, 2012
    Assignees: Hanuman, LLC, Biomet Biologics, LLC
    Inventors: Randel Dorian, Scott R. King, Richard W. Storrs
  • Publication number: 20120129673
    Abstract: The weight difference is limited between buckets (17) mounted at respective symmetrical positions with respect to a centrifugal separation rotational center and examination of samples is continuously performed in the order in which they are received. In particular, when a sample (21) is carried in a centrifugal buffer line (11), its weight is measured by weight measuring means (31). It is assumed that the names of two adaptors (22) placed at respective symmetrical positions with respect to the centrifugal separation rotational center are defined as an adaptor A and an adaptor B. A first sample is put on the adaptor A and a second sample is put on the adaptor B. Then, a third sample and subsequent ones are each put on the adaptor (22) lighter than the other adaptor after the total weights of samples put on the adaptors are computation-compared with each other.
    Type: Application
    Filed: July 28, 2010
    Publication date: May 24, 2012
    Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
    Inventors: Tatsuya Fukugaki, Hiroshi Oga, Shigemi Oba, Tetsuya Isobe, Kuniaki Onizawa
  • Patent number: 8167139
    Abstract: The invention includes compositions of stem and progenitor cells recovered from bone marrow or cord blood containing most of the viable CD34+ cells and substantially depleted of red blood cells resident in the original sample, without any xenobiotic additives to aid cell separation. The invention also includes a system and method for preparing the compositions. The system includes a bag set and a processing device, which utilizes an optical sensor, microcontroller, servo motor, accelerometer, load cell, and battery. The system and method utilize centrifugation to stratify the cells into layers and then separate and transfer the stem cells into a stem cell bag. The processing device's microcontroller receives input from the device's accelerometer, load cell and optical sensor to direct the metering valve in the bag set to open and close to permit the transfer of as many stems cells as possible with as few red cells as possible.
    Type: Grant
    Filed: July 6, 2007
    Date of Patent: May 1, 2012
    Assignee: ThermoGenesis Corp.
    Inventors: Philip H. Coelho, Bruce A. Baker, John R. Chapman, Junzhi Li, Prince Emmanuel, Robert S. Childers
  • Patent number: 8147392
    Abstract: A centrifuge rotor includes a rotor body having first and second axial ends and a circumferential sidewall extending therebetween. The rotor body has a plurality of wells for receiving sample containers to be processed in the rotor. The rotor further includes an elongate reinforcement extending around the circumferential sidewall of the rotor body along a helical path. At least two portions of the elongate reinforcement interlock at one or more specific points on the surface of the rotor.
    Type: Grant
    Filed: February 24, 2009
    Date of Patent: April 3, 2012
    Assignee: Fiberlite Centrifuge, LLC
    Inventors: Sina Piramoon, Alireza Piramoon