Abstract: A centrifugal processing unit for directing the movement of substances within a sample processing cartridge having a rotor for receiving the sample processing cartridge, a rotor drive to create a centrifugal force, the centrifugal processing unit having a pivot accommodation and a fix accommodation for receiving the sample processing cartridge that are arranged on the rotor, where each pivot accommodation being adapted to allow a free pivoting motion of the received sample processing cartridge about a respective pivot axis, and each pivot axis being orthogonal to the rotor axis to the respective force vector of the centrifugal force.

Abstract: Devices, systems, and methods are provided for mixing by asymmetric rotation using a servo motor to drive the symmetric rotation. The system may include a robotic arm and robotic controller.

Abstract: The present disclosure provides a method of cell sedimentation and retention of target cells, for example circulating tumour cells, CTC, from a fluid sample onto a solid support. The method comprises placing a fluid medium comprising the target cells in a fluid chamber, the fluid chamber having an open end sealed against a surface of the solid support. The method further comprises subjecting the fluid medium to centrifugation within the fluid chamber to induce sedimentation of the target cells and promote cell adhesion to the surface of the solid support. The method further comprises, post-centrifugation, positioning a fluid absorbing element in the fluid chamber to remove fluid from the fluid chamber. The method further comprises controlling a flow rate of the fluid being absorbed by the fluid absorbing element such that the sedimented cells are not detached from the surface of the solid support.

Abstract: A device and a method for reducing wind resistance power of a large geotechnical centrifuge are provided. A semicircular tube cylindrical cooling device is provided between an internal side of a high-speed rotor system and a cylindrical shell. A serpentine top semicircular tube cooling plate is provided right above a hanging basket, and return helium gas inlet holes are provided at a center of the top semicircular tube cooling plate. A helium gas in a helium gas storage tank passes through helium gas outlets on the helium gas inlet pipes, and enters a centrifuge chamber from a bottom sealing plate. The helium gas is used to replace air in the centrifuge chamber to reduce the wind resistance power and corresponding energy consumption. No vacuuming is required, so sealing requirements are lower. Heat dissipation equipment is placed inside the centrifuge chamber, and a helium gas circulation wind duct is added.

Abstract: A method of testing a biological sample, the method comprising: providing a centrifuge sample holder having a camera; arranging a transparent container comprising a fluid test medium in a recess of said centrifuge sample holder, wherein the camera is arranged to image a portion of the container comprising said fluid test medium; arranging said biological sample above and not in contact with said fluid test medium in said container; and with the camera, imaging a mixing of said biological sample with said fluid test medium while centrifuging the sample holder.

Abstract: A weighing device to weigh at least one container suitable to contain one or more substances, including weighing means and a body connected to the weighing means and in which a compartment is defined, configured to temporarily house the container and provided with an aperture defining a passage gap for the introduction of the container inside the compartment along an axis of introduction, in which the body also includes a plurality of holding levers to hold the container inside the compartment.

Abstract: A rotor assembly includes a rotor plate to rotate around a first axis; a bucket rotatably attached to the rotor plate and to rotate around a second axis; and a stop plate to rotate around the first axis relative to the rotor plate between an open position and a closed position, when in the closed position, the stop plate is to engage the bucket to fix an angular position of the bucket relative to a plane of rotation of the rotor assembly.

Abstract: A centrifugal processing unit for directing the movement of substances within a sample processing cartridge, the centrifugal processing unit having a rotor at least one accommodation for receiving the sample processing cartridge, and a rotor drive for rotating the at least one rotor about a respective rotor axis to create the centrifugal force. The centrifugal processing unit has a blocking element allowing the free pivoting motion of the at least one accommodation in a release position when the rotor is rotated in a first direction and preventing the free pivoting motion in a blocking position, when the rotor is rotated in the opposite direction.

Abstract: The present disclosure provides a cell harvesting method and device for the efficient sedimentation and retention of cells from liquid samples onto a solid support with low cell losses and low impact on cell morphology. The device has two configurations, one being for use in a centrifuge to centrifuge the sample, a second for controlled release of the liquid post centrifugation. The device includes a base to hold a solid support that receives cells on a top surface thereof that releasably holds a fluid chamber which has a first opening with a gasket surrounding the opening with that bears against a top surface of the support. An opening receives the liquid sample and the gasket defines an area into which the targeted cells deposit. A first cap closes the second opening during centrifugation.

Abstract: The present disclosure provides a cell harvesting method for the efficient sedimentation and retention of cells from liquid samples onto a solid support with low cell losses and low impact on cell morphology.

Abstract: Embodiments can provide a test tube vacuum retainer system, comprising an outer body comprising a midline plate; one or more side walls, a bottom wall, and a top plate comprising an access hole; a test tube holder comprising a sealant ring; a base; and a vacuum tube comprising an external outlet; wherein the test tube holder is secured within the outer body to the base, which in turn is secured to the midline plate; wherein the vacuum tube is connected to the test tube holder at a first end, and the external outlet is configured to be connected to a vacuum pump configured to apply a vacuum force to the test tube holder when a test tube is inserted into the access hole and placed onto the test tube holder.

Abstract: The bioenvironmental simulation device according to an embodiment of the present invention includes at least one mounting unit on which cells to be measured are placed, a rotational force application unit configured to rotate the mounting unit so as to apply a rotational force to the cells to be measured placed on the mounting unit, and a culture liquid flow device through which a culture liquid flows across the mounting unit, wherein the culture liquid flows by the culture liquid flow device so as to apply a shear force to the cells to be measured.

Abstract: The present disclosure provides a rotary motor, which includes: a clamping member having a gripping unit installed at an inner circumference of a rotor to grip the rotor during a predetermined time; and a driving member installed at the inner circumference of the rotor and having a rotation unit configured to make an elastic deformation to rotate by a predetermined angle and then return to an original state so that the rotor is rotated.

Abstract: The present disclosure provides a cell harvesting method and device for the efficient sedimentation and retention of cells from liquid samples onto a solid support with low cell losses and low impact on cell morphology. The device has two configurations, one being for use in a centrifuge to centrifuge the sample, a second for controlled release of the liquid post centrifugation. The device includes a base to hold a solid support that receives cells on a top surface thereof that releasably holds a fluid chamber which has a first opening with a gasket surrounding the opening with that bears against a top surface of the support. An opening receives the liquid sample and the gasket defines an area into which the targeted cells deposit. A first cap closes the second opening during centrifugation.

Abstract: A swinging bucket centrifuge (1) comprises a rotor (10) with at least one mounting end and at least one bucket (20) mounted to the at least one mounting end of the rotor (10). Therein, the at least one bucket (20) is mounted to the at least one mounting end of the rotor (10) by at least one clevis pin (30) held in a clevis (13) so that the bucket (20) is pivotable about the clevis pin (30).

Abstract: A centrifuge includes a swing rotor. Rotor arms of the swing rotor have recesses into which hangers of the swing rotor at least partially swing in a swung-out state. As a result, the centrifuge container and thus also the centrifuges are more compact, because the swinging-out requires less space. An inertial mass of the swing rotor is reduced due to the recesses provided therein, whereby energy consumption, primarily when starting the centrifuge, is significantly reduced.

Abstract: A rotor assembly includes a rotor plate to rotate around a first axis; a bucket rotatably attached to the rotor plate and to rotate around a second axis; and a stop plate to rotate around the first axis relative to the rotor plate between an open position and a closed position, when in the closed position, the stop plate is to engage the bucket to fix an angular position of the bucket relative to a plane of rotation of the rotor assembly.

Abstract: A modular centrifuge device for separating fluid samples, including a housing having a modular power assembly mechanism for rotating samples with manual or electric power. A manual centrifuge device, including a housing having a power assembly mechanism for rotating samples with manual power, and a speed indicator for indicating if a predetermined speed has been reached and a time indicator for indicating if a predetermined or calculated time has been reached for rotating said samples operatively connected to the device. A method of centrifuging samples, by selecting a manual power mode or electric power mode on a centrifuge, rotating samples at a predetermined speed for a predetermined or calculated time, alerting a user that the predetermined speed and predetermined or calculated time have been achieved, and obtaining separated samples.

Abstract: A system for manufacturing a discrete object from an additively manufactured body of material including a precursor to a discrete object and at least a reference feature is disclosed. The system includes an automated manufacturing device, the automated manufacturing device including at least a controller configured to receive a graphical representation of precursor to a discrete object, receive a graphical representation of at least a reference feature on the precursor to the discrete object, and generate a computer model of the body of material, wherein the computer model of the body of material includes the graphical representation of the precursor to the discrete object and the graphical representation of the at least a reference feature.

Abstract: A sample preparation apparatus includes a robotic system providing movement in three orthogonal directions to an arm operable to receive a pipette tip and to facilitate movement of fluid into and out of the pipette tip. Optionally, the robot can include a gripper arm in addition to the pipette receiving arm. In addition, the sample preparation apparatus can include a tray for receiving pipette tips, receptacles for receiving tubes, an apparatus for forming an emulsion, a device for forming particles that include copies of the polynucleotide, a device for enriching the particles, as well as a centrifuge for loading such particles onto a sensor array. The sample preparation apparatus can further include receptacles for holding containers of reagent solutions.

Abstract: A rotor assembly includes a rotor plate to rotate around a first axis; a bucket rotatably attached to the rotor plate and to rotate around a second axis; and a stop plate to rotate around the first axis relative to the rotor plate between an open position and a closed position, when in the closed position, the stop plate is to engage the bucket to fix an angular position of the bucket relative to a plane of rotation of the rotor assembly.

Abstract: A centrifuge to which sample tubes can be introduced while the centrifuge is in motion. The centrifuge comprises a carousel having an upper portion and a lower portion. The upper portion of the carousel has a plurality of positions for sample tubes for a centrifugation operation, a plurality of drive mechanisms attached to the upper portion of the carousel, a movable element mounted upon each drive mechanism, the movable element capable of traversing the length of the drive mechanism when the drive mechanism is actuated, a sample tube-holding assembly comprising a sample tube holder and a bearing attached to each movable element, and at least one balancing element capable of contributing to a force vector that cancels an imbalance vector generated by rotation of the centrifuge.

Abstract: A centrifuge including a lid section of a sample container, the lid section having a rotating shaft for swinging, and a swing-type rotor, and the centrifuge conducts centrifugation operation in a state where the sample container is seated in a bucket housing section by making the sample container in which the rotating shaft is mounted to a rotating shaft engagement groove of the rotor swing due to the rotation of the rotor. The rotating shaft comprises a plurality of members connected by a connection section and is configured so as to be bendable at the connection section by a centrifugal load accompanying the rotation of the rotor.

Abstract: Adapter for inserting a sample container in a centrifuge bucket, comprising a bucket-like base body, which delimits a cavity for accommodating the sample container and has a bottom region and an adjoining side wall region, the top edge of which defines an opening edge of the cavity, and an insertion opening, through which the sample container can be inserted in the cavity and which is delimited by the opening edge, at least one separation joint being present in the side wall region of the base body, which separation joint extends from the opening edge in the direction towards the bottom region and which allows for expanding the side wall region from a starting position (P1) to an expanded position (P2) by applying a force in such a way that the opening edge has a larger circumference as compared to the starting position (P1).

Abstract: A centrifuge and a rotor thereof are provided. The centrifuge performs centrifugation in a state where the sample container is swung by rotation and seated in a cutout part of a rotor body. The sample container includes a bucket accommodating a container filled with a sample, and a lid for sealing the bucket and having a rotation shaft. Grooves extending in the longitudinal direction are formed on the outer peripheral surface of the bucket on the bottom side with respect to a seating surface of the bucket. The grooves are arranged at equal intervals in the circumferential direction. Formation of the grooves can prevent increasing the weight of the bucket and realize a highly rigid sample container that can withstand deformation.

Abstract: Provided is a swing rotor for a centrifuge. The centrifuge includes a swing type rotor body having a plurality of holding pins and a plurality of buckets held by the holding pins in a swingable manner. On the rotor body, a connection part is formed to connect two branch arms that diverge from an arm part on an outer peripheral side. A thickness-reduced part penetrating in the same direction as a driving shaft is formed in a region surrounded by the two branch arms on an inner peripheral side of the connection part. Since the branch arms deform accordingly to a certain extent, partial concentration of the stress applied on the holding pins due to a centrifugal load can be alleviated. Thus, the lifespan of the centrifuge can be improved and the centrifugal separation operation can be stabilized.

Abstract: A knuckle thrower for a railway coupler assembly, the thrower having a knuckle actuating leg, a leg lock seat, an upper pivot structure, a lower trunnion, and stress relief feature for relieving stresses imparted on the thrower, which, according to some embodiments may include a recess provided in the perimeter wall thereof, and one or more supporting ribs.

Abstract: A spring operated swing out rotor system for a centrifuge includes a rotor with a rotor top and a rotor bay extending down from the rotor top, the rotor bay having a bay wall and a bay bottom; a carrier tray rotatably attached to a retaining element on the bay wall; and a compression-resistant element between the tray and the bay wall urging the tray to rotate away from the bay wall, so that when the rotor is at rest, the tray is maintained at a positive angle from vertical, and when the centrifuge spins the rotor, centrifugal force positions the tray at a vertical angle. The compression-resistant element may be a spring or soft foam.

Abstract: The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.

Abstract: A housing for an automated centrifuge with side and top access is disclosed. The housing includes an inner housing (104) for enclosing at least one labware nest (108) of the automated centrifuge, the inner housing having a top and a substantially cylindrical body, wherein the inner housing includes an opening through both a portion of the top and a portion of the body; and a door (114) configured to move between an open position in which the door exposes the opening and a closed position in which the door blocks the opening.

Abstract: An apparatus includes a robotic system providing movement in three orthogonal directions to an arm operable to receive a pipette tip and to facilitate movement of fluid into and out of the pipette tip. In addition, the apparatus can include a tray for receiving pipette tips, receptacles for receiving tubes, an apparatus for forming an emulsion, a device for forming particles that include copies of the polynucleotide, a device for enriching the particles and an apparatus for loading such particles onto a sensor array. The apparatus can further include receptacles for holding containers of reagent solutions. Optionally, the robot can include a gripper arm in addition to the pipette receiving arm.

Abstract: A cartridge is configured for insertion and centrifugation in a centrifuge. The cartridge includes a first drum which has a first chamber, and a displacement device which is designed to rotate the first drum about a center axis thereof to selectively and conductively connect the first chamber to a second or a third chamber. In another embodiment, the cartridge includes a first drum which has a first chamber and a second chamber, and a displacement device which is designed to rotate the first drum about the center axis thereof to selectively and conductively connect the first chamber to a third chamber or the second chamber to the third chamber. The displacement device has an actuator which directly or indirectly moves the first drum about the center axis.

Abstract: The present disclosure relates to a detection system for detecting a liquid level in a rotating driveline component. The detection system may include a first sensor for detecting the liquid, a second sensor for detecting a rotational position of the driveline component, and a receiver for determining the liquid level based on the first and second sensors.

Abstract: A centrifuge to which sample tubes can be introduced while the centrifuge is in motion. The centrifuge comprises a carousel having an upper portion and a lower portion. The upper portion of the carousel has a plurality of positions for sample tubes for a centrifugation operation, a plurality of drive mechanisms attached to the upper portion of the carousel, a movable element mounted upon each drive mechanism, the movable element capable of traversing the length of the drive mechanism when the drive mechanism is actuated, a sample tube-holding assembly comprising a sample tube holder and a bearing attached to each movable element, and at least one balancing element capable of contributing to a force vector that cancels an imbalance vector generated by rotation of the centrifuge.

Abstract: A gripper unit for handling a vessel for receiving biological material is proposed, inter alia. The vessel has a lid which can assume an open position and a closed position. The gripper unit comprises a gripper for gripping and releasing the vessel, and a lid holder, for holding a lid in a defined position in relation to the vessel. The defined position is an open position of the lid.

Abstract: A gripper unit for handling a vessel for receiving biological material is proposed, inter alia. The vessel has a lid which can assume an open position and a closed position. The gripper unit comprises a gripper for gripping and releasing the vessel, and a lid holder, for holding a lid in a defined position in relation to the vessel. The defined position is an open position of the lid.

Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.

Abstract: Instrumentation is provided for the separation of a multiple component sample, such as BMA containing lysed red blood cells and a lysing agent, into a desired component, for example a cell pellet containing stem cells, and a remaining component. The application discloses a device that includes a separator configured to separate the desired portion from the remaining portion, a collector that is supported by the separator and configured to collect the desired component of the multiple component sample after the desired component has been separated from the remaining component by the separator, and a housing that at least partially encloses and supports the separator and the collector.

Abstract: A centrifugal separator comprising: a driving portion; and a swing rotor including, a rotor body, a through-hole passing through the rotor body, pin insert grooves which are provided parallel to the through-hole so as to oppose each other and only partially penetrate the rotor body, and a bucket including, a bucket body that has a contact surface which is configured to contact the rotor body during centrifugal separation, and a cap assembly that seals the bucket body and has a swing shaft extending in a direction perpendicular to an longitudinal direction of the bucket, wherein the swing rotor is rotated when the bucket is inserted into the through-hole, to swing the bucket, and the swing shaft can be moved in the longitudinal direction of the bucket relative to the bucket body and rotated about a longitudinal central axis of the bucket.

Abstract: An apparatus for automatically centrifuging test tubes containing biological material including a plurality of centrifuges functionally identical to one another yet independent and adapted to centrifuge test tubes offered to an interface for centrifuging test tubes using a conveying system included in an automatic conveyor of test tubes. The plurality of centrifuges is fitted on a turntable adapted to offer each centrifuge at a suitable loading/unloading point adjacent to the loading/unloading point of the interface. Each centrifuge is provided with a motor adapted to generate the centrifugal motion by setting a rotor in rotation, and a test tube handling device including an arm with a first gripper adapted to load test tubes to be centrifuged and a second gripper adapted to unload centrifuged test tubes, simultaneously to the loading, the arm sliding along a curved guide adapted to generate a forced rotation of the grippers.

Abstract: The present invention relates to improved methods for processing fluids and to a fluid processing device (1) for use in a centrifuge comprising: (a) a first holder (14) form-fit to the shape of a first tube (18) for holding said first tube (18) whereby said first tube (18) has a first cross section (A1); and (b) a second holder (22) form-fit to the shape of a second tube (26) for holding said second tube (26) whereby said second tube (26) has a second cross section (A2) that is different from said first cross section (A1). With the fluid processing devices and the methods according to the invention, it is possible to simplify the centrifugal processing steps for a given fluid processing sequence and to automate them.

Abstract: The present invention relates to a centrifuge insert for sample holders and to a carrier for a centrifuge insert for sample holders. The centrifuge insert according to the invention has substantial advantages over known centrifuge inserts. These advantages are not limited to the fact that the carrier is attachable and detachable in a particularly easy and comfortable manner. It is also feasible to use different carriers for different sample holders. Furthermore, the centrifuge insert according to the invention is configured particularly light and compact so that the loading of the rotor is significantly lower for identical centrifugation powers or so that significantly higher RCA values can be used.

Abstract: An automated centrifuge apparatus for conducting a cell preparation procedure is provided. A rotor assembly supports centrifuge tubes, which are installable at respective tube positions. The tube positions are indexable to an index location. A sensing module monitors the index location during a set of status checks, which relate to the centrifuge tubes. Logic signals generated by the sensing module are used to automatically determine whether the status checks are satisfied.

Abstract: A centrifuge is provided. The centrifuge includes a power source, the power source configured to generate electrical power from a renewable power source. At least one battery electrically coupled to the power source. A motor is electrically coupled to the at least one battery. A rotor is coupled to the motor. The rotor has a generally cylindrical body and a pair of opposing openings opposite the motor, and a pair of holders each disposed in one of the pair of opposing openings, each of the holders having an opening on one end sized to receive a capillary tube.

Abstract: Centrifuges have been designed in the past for centrifuging multi-welled containers, but they are limited in centripetal acceleration or have a large footprint. The invention provides a centrifuge with a high centripetal acceleration and imbalance tolerance while maintaining a small footprint and being able to integrate with laboratory automation equipment. Methods and apparatuses for centrifugation include a rotor assembly positioned within a shield assembly suspended in a centrifuge. The rotor assembly is operably connected to the motor for rotating payloads (e.g., multi-welled containers) around an axis. The shield assembly is positioned such that the center of mass is aligned with the axis of rotation of the rotor assembly and the plane containing the rotational imbalance force vector. This alignment allows rotation of the container with an acceleration of at least 2000 g (or at least 3000 g, 4000 g, 5000 g, etc.).

Abstract: A swing rotor for a centrifugal separator, the swing rotor including: a hub; and a rotor body disposed around the hub, wherein a plurality of pairs of arms are disposed at the rotor body, wherein a holding pin configured to hold a bucket is disposed to the arm, wherein an engagement portion which is configured to be supported by the holding pin is formed to the bucket, and wherein a sliding surface of the holding pin with an engagement portion of the bucket is formed such that a width of a contact area, which is an area that the holding pin contacts with the engagement portion of the bucket, in an axial direction when the bucket does not swing differs from a width of the contact area in the axial direction when the bucket reaches a horizontal position by swinging during a centrifugal separation operation.

Abstract: A centrifuge rotor is provided having a rotor core that defines a rotational axis of the rotor. A plurality of bucket supports is arranged about the axis of rotation. The rotor includes first and second straps that respectively wrap around two diametrically-opposed ones of the bucket supports for restricting outward movement of the two bucket supports relative to the rotor core. The first and second straps intersect one another at a location through the axis of rotation of the rotor.

Abstract: The present invention provides systems, devices, and methods for point-of-care and/or distributed testing services. The methods and devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device can be modified to allow for more flexible and robust use with the disclosed methods for a variety of medical, laboratory, and other applications. The systems, devices, and methods of the present invention can allow for effective use of samples by improved sample preparation and analysis.

Abstract: A centrifuge rotor is provided. The rotor includes a compression-molded rotor body that includes a central hub defining an axis of rotation of the rotor body, and a plurality of bays, each configured to receive a bucket therein. A plurality of load transferring members are integrally molded with the rotor body and each include a bucket support for supporting a bucket, with the bucket support permitting pivoting movement of the bucket during centrifugation of the rotor body about the axis of rotation. A reinforcement layer extends circumferentially and/or helically around an exterior of the rotor body.

Abstract: A centrifuge includes a rotator comprising a receiving unit receiving materials and guiding the materials to move upward by centrifugal force to an upper portion of the receiving unit, and a rotator cover covering the upper portion of the receiving unit. The centrifuge also includes a container that is coupled to the rotator cover to be connected to the receiving unit and that receives the materials moved upward along the receiving unit. The centrifuge and a centrifuging method as disclosed herein are used for separating a fluid to which a large centrifugal force is applied and a fluid to which a smaller centrifugal force is applied by adjusting the rotation speed using the principle that centrifugal force during rotation varies according to specific components of a fluid. Thus, using the centrifuge and the centrifugal method, materials can be centrifuged and layers of the materials can be classified and collected accurately and easily.