Comprising Flexible Bowls Embraced By Pockets Provided Therefor In Carrier Patents (Class 494/21)
  • Patent number: 9238096
    Abstract: The invention relates to a method and a device for separating blood using a centrifuge in order to obtain different blood fractions. The aim of the invention is to eliminate the risk of contamination during the supply of blood and the removal of blood fractions. To achieve this, the separation container is filled with blood via a feed connection that can be aseptically connected to the container, the relevant blood fraction is removed from the separation container via a removal connection that can be aseptically connected to the container and both the feed device and the removal device form a respective closed system during the sterile connection to the separation container. The separation container (4) has at least one feed connection (5, 6) that can be aseptically connected to the container and at least one removal connection (7) that can be aseptically connected to the container, to which hermetically sealed feed and removal devices (8, 9, 10) can be aseptically attached in a sterile manner.
    Type: Grant
    Filed: September 13, 2009
    Date of Patent: January 19, 2016
    Inventor: Walter Pobitschka
  • Patent number: 9199250
    Abstract: The present invention relates to methods, devices and systems for separation and concentration of particles from liquid and fluid samples. In some embodiments, the separation/concentration is achieved by sequential centrifugation steps. In particular, one aspect of the invention relates to a separation/concentration device which comprises at least a first chamber (101) and a second chamber (103) connected by a first valve (111), whereby operation of the first valve controls the material transfer from the first chamber to the second chamber. In some embodiments, valve operation can be manually, semi-manually or automatically. Other aspects of the invention relate to single- or multi-chambered separation/concentrator devices, and methods and systems for use. Other aspects of the invention relate to devices for operation of the valves, e.g., semi-manual actuation devices, and automatic inertial activation devices and mechanical actuation devices present in purpose-built centrifuges.
    Type: Grant
    Filed: April 30, 2010
    Date of Patent: December 1, 2015
    Assignees: Trustees of Boston University, Fraunhofer USA, Inc.
    Inventors: Andre Sharon, Alexis Sauer-Budge, Aaron Size, Holger Wirz
  • Patent number: 8469202
    Abstract: A centrifugal processing bag, system and method for separating the components of a mixed material is presented. The processing bag includes a hub and a first port for receiving the mixed material, where the first port includes an outlet positioned within the processing bag at a perimeter of the bag. The processing bag also including a second port having a second port inlet spaced proximate the hub and away from a central axis of the hub. The second port directs a separated material collected from the second port inlet out of the processing bag.
    Type: Grant
    Filed: November 1, 2010
    Date of Patent: June 25, 2013
    Assignee: Velico Medical, Inc.
    Inventor: Keith M. Rosiello
  • Patent number: 8167139
    Abstract: The invention includes compositions of stem and progenitor cells recovered from bone marrow or cord blood containing most of the viable CD34+ cells and substantially depleted of red blood cells resident in the original sample, without any xenobiotic additives to aid cell separation. The invention also includes a system and method for preparing the compositions. The system includes a bag set and a processing device, which utilizes an optical sensor, microcontroller, servo motor, accelerometer, load cell, and battery. The system and method utilize centrifugation to stratify the cells into layers and then separate and transfer the stem cells into a stem cell bag. The processing device's microcontroller receives input from the device's accelerometer, load cell and optical sensor to direct the metering valve in the bag set to open and close to permit the transfer of as many stems cells as possible with as few red cells as possible.
    Type: Grant
    Filed: July 6, 2007
    Date of Patent: May 1, 2012
    Assignee: ThermoGenesis Corp.
    Inventors: Philip H. Coelho, Bruce A. Baker, John R. Chapman, Junzhi Li, Prince Emmanuel, Robert S. Childers
  • Patent number: 8066127
    Abstract: An apparatus and method for collecting whole blood and then separating it into components for subsequent use or storage. A self-contained bag set is used to collect the sample, which may then be placed into a device adapted to fit into a centrifuge for separation of components. Each component is then sequentially extracted according to density, with a sensor present in the device to control the operation of valves directing the collection of each component. The sensor may be reading one or more of the following characteristics: infrared, optics, density, weight, radioactive, fluorescence, color, magnetism, ultrasonic, capacitance wherein the characteristic is inherent in the blood and blood component or is an additive. Each component may then be separated into its own storage container. The preferred sensors include optics and weight.
    Type: Grant
    Filed: August 16, 2005
    Date of Patent: November 29, 2011
    Assignee: ThermoGenesis Corp.
    Inventors: Philip H. Coelho, Eric Sommer, Richard Klosinski, Jim Hobbs, Bruce Baker, Brian Malone
  • Publication number: 20110077140
    Abstract: An apparatus for separating a volume of composite liquid into at least a first component and a second component comprising a centrifuge having a rotor with a turntable for supporting a separation bag; a central compartment for containing satellite bags, and fitted with a support member for supporting at least one satellite bag so that a liquid contained in the supported satellite bag drains from the supported satellite bag into the separation bag under centrifugation forces when the rotor is set in rotation.
    Type: Application
    Filed: August 14, 2006
    Publication date: March 31, 2011
    Applicant: GAMBRO BCT, INC.
    Inventors: Brian M. Holmes, Johan-Petter Hagström
  • Patent number: 7824558
    Abstract: A centrifugal processing bag, system and method for separating the components of a mixed material is presented. The processing bag includes a hub and a first port for receiving the mixed material, where the first port includes an outlet positioned within the processing bag at a perimeter of the bag. The processing bag also including a second port having a second port inlet spaced proximate the hub and away from a central axis of the hub. The second port directs a separated material collected from the second port inlet out of the processing bag.
    Type: Grant
    Filed: June 26, 2006
    Date of Patent: November 2, 2010
    Assignee: Velico Medical, Inc.
    Inventor: Keith M. Rosiello
  • Patent number: 7819793
    Abstract: An apparatus for separating blood into blood components using a separation vessel satellite bags mounted on a centrifuge rotor and a balancing assembly for the centrifuge to compensate for changes to the center of gravity.
    Type: Grant
    Filed: May 22, 2007
    Date of Patent: October 26, 2010
    Assignee: CaridianBCT, Inc.
    Inventors: Hans Lindell, Thomas L. Menhennett, Johan-Petter Hogström, Per-Olov Jan Lundberg, Brian M. Holmes, Charles L. Hake, Daniel A. Joseph
  • Publication number: 20100216622
    Abstract: A centrifuge rotor includes a rotor body having first and second axial ends and a circumferential sidewall extending therebetween. The rotor body has a plurality of wells for receiving sample containers to be processed in the rotor. The rotor further includes an elongate reinforcement extending around the circumferential sidewall of the rotor body along a helical path. At least two portions of the elongate reinforcement interlock at one or more specific points on the surface of the rotor.
    Type: Application
    Filed: February 24, 2009
    Publication date: August 26, 2010
    Applicant: FIBERLITE CENTRIFUGE, LLC
    Inventors: Sina Piramoon, Alireza Piramoon
  • Patent number: 7670563
    Abstract: A centrifuge has a bucket for receiving the product to be centrifuged, and a support which is configured to be inserted in the bucket and receive microtiter plates and the like. The support has substantial stability and comprises a generally planar base and four upstanding lateral walls which are integrally formed with the base and which are coupled together at their upper edges to form a substantially self-contained enclosure.
    Type: Grant
    Filed: February 15, 2006
    Date of Patent: March 2, 2010
    Assignee: European Molecular Biology Laboratory
    Inventors: Jürgen Zimmermann, Christian Boulin, Vladimir Benes, Leo Burger
  • Publication number: 20100009832
    Abstract: The present invention relates to improved methods for processing fluids and to a fluid processing device (1) for use in a centrifuge comprising: (a) a first holder (14) form-fit to the shape of a first tube (18) for holding said first tube (18) whereby said first tube (18) has a first cross section (A1); and (b) a second holder (22) form-fit to the shape of a second tube (26) for holding said second tube (26) whereby said second tube (26) has a second cross section (A2) that is different from said first cross section (A1). With the fluid processing devices and the methods according to the invention, it is possible to simplify the centrifugal processing steps for a given fluid processing sequence and to automate them.
    Type: Application
    Filed: September 26, 2006
    Publication date: January 14, 2010
    Inventors: Andreas Schaefer, Thomas Voit, Markus Zbinden
  • Patent number: 7211191
    Abstract: An apparatus and method for collecting whole blood and then separating it into components for subsequent use or storage. A self-contained bag set is used to collect the sample, which may then be placed into a device adapted to fit into a centrifuge for separation of components. Each component is then sequentially extracted according to density, with a sensor present in the device to control the operation of valves directing the collection of each component. Each component may then be separated into its own storage container.
    Type: Grant
    Filed: September 30, 2004
    Date of Patent: May 1, 2007
    Assignee: ThermoGenesis Corp.
    Inventors: Philip H. Coelho, Eric Sommer, Richard Klosinski, Jim Hobbs
  • Patent number: 7128838
    Abstract: A removable conformal liner for a centrifuge container is described. The liner has a flexible or semi-rigid body with an opening for introducing a sample. When the liner is inserted into an internal cavity of a centrifuge container, the body of the liner conforms to the interior cavity. The liner body may be made of a material that is sufficiently resilient to allow a reversible deformation of the body by folding, twisting, collapsing, rolling, or pleating.
    Type: Grant
    Filed: January 16, 2004
    Date of Patent: October 31, 2006
    Assignee: Beckman Coulter, Inc.
    Inventors: Melvin Dorin, Patrick Q. Moore
  • Patent number: 7074172
    Abstract: A centrifugal processing bag, system and method for separating the components of a mixed material is presented. The processing bag includes a hub and a first port for receiving the mixed material, where the first port includes an outlet positioned within the processing bag at a perimeter of the bag. The processing bag also including a second port having a second port inlet spaced proximate the hub and away from a central axis of the hub. The second port directs a separated material collected from the second port inlet out of the processing bag.
    Type: Grant
    Filed: August 2, 2002
    Date of Patent: July 11, 2006
    Assignee: ZymeQuest, Inc.
    Inventor: Keith Rosiello
  • Patent number: 7001321
    Abstract: A fluid processing assembly can be easily inserted into and removed from a rotatable centrifuge channel. The processing assembly comprises a processing container and a carrier. The processing container has flexibility and, in use, occupies the channel to receive fluids for separation in the centrifugal field. The carrier retains the processing container outside the channel in a flexed condition conforming to the channel. The carrier resists deformation of the processing container during its insertion into or removal from the channel.
    Type: Grant
    Filed: March 30, 1998
    Date of Patent: February 21, 2006
    Assignee: Baxter International Inc.
    Inventors: Richard I. Brown, Ying-Cheng Lo
  • Publication number: 20040185998
    Abstract: A method for separating a composite fluid into components in a centrifugal fluid separation system. The system includes a rotor that has a composite fluid containment area, an inlet channel, a peripheral separation channel, outlet channels and separated component collection areas, which together form a processing area. The separation channel may be semi-spiraled. The inlet channel may connect to the center of the separation channel and an outlet channel may connect to each end of the separation channel. The outlet channels have different heights. The ends of the separation channels may have different heights. The separation channels may have extensions. The rotor may have multiple processing areas. The collection areas may be pockets slanted radially outwardly and downwardly. A motor may produce a rotating magnetic field, which co-acts with a magnetically reactive material in the rotor. A disposable bag and tubing system may be used in a processing area of the rotor.
    Type: Application
    Filed: April 12, 2004
    Publication date: September 23, 2004
    Applicant: GAMBRO, INC.
    Inventors: Dennis J. Hlavinka, Thomas J. Felt
  • Patent number: 6746601
    Abstract: A removable conformal liner for a centrifuge container is described. The liner has a flexible or semi-rigid body with an opening for introducing a sample. When the liner is inserted into an internal cavity of a centrifuge container, the body of the liner conforms to the interior cavity. The liner body may be made of a material that is sufficiently resilient to allow a reversible deformation of the body by folding, twisting, collapsing, rolling, or pleating.
    Type: Grant
    Filed: August 5, 2002
    Date of Patent: June 8, 2004
    Assignee: Beckman Coulter, Inc.
    Inventors: Melvin Dorin, Patrick Q. Moore
  • Publication number: 20040065626
    Abstract: A simple blood separation kit that is suitable for small surgeries for single-usage to separate whole blood into blood components, the separation kit comprising: a) two reservoirs for separating whole blood into blood components, each reservoir being connected to the other reservoir via a hollow tube at an outlet/inlet port, permitting transfer of blood components between said reservoirs; b) a pump mechanism in communication with the two reservoirs via the hollow tube and for injecting/suctioning blood components into and out of the reservoirs via the hollow tube; and c) a valve means for substantially closing the inlet/outlet port of the reservoirs while the pump mechanism is in operation injecting/suctioning blood components into or out of the reservoirs.
    Type: Application
    Filed: October 2, 2002
    Publication date: April 8, 2004
    Inventor: Tony Woo
  • Publication number: 20030195104
    Abstract: A centrifugal fluid separation system is disclosed for centrifugally separating a composite fluid into components thereof. This centrifugal separation system includes at least a centrifugal rotor which has a composite fluid containment area, a fluid flow channel/tubing and at least one separated component collection area defined therein. A composite fluid to be separated is delivered to the fluid containment area where under centrifugal forces the composite fluid is separated into components and then from which a component travels through an outlet channel to a respective separated component fluids flowing therethrough. A centrally disposed pump is also provided to move the separated component(s) to the collection area(s). Optical sensing of the interface of the separated fluid components may be used with a clamp to stop flow. A disposable bag and tubing system is also disclosed for use with reusable rotor devices.
    Type: Application
    Filed: April 14, 2003
    Publication date: October 16, 2003
    Applicant: Gambro, Inc.
    Inventors: Dennis J. Hlavinka, William G. Palsulich, Thomas J. Felt, Frank Corbin
  • Patent number: 6629918
    Abstract: An adapter for supporting a flexible container in a cylindrical cavity of centrifuge carrier. The adapter is of a size that can be received in the cavity and comprises a wall comprised of a flexible material. The wall comprises a first concave wall portion having a first curvature and a second wall portion having a second curvature that is lower than the first curvature. The first wall portion is concave with reference to the flexible container. The first wall portion and the second wall portion are diametrically opposed to each other so as to receive the flexible container in an interior region substantially bounded by an inner surface of the wall. The invention also pertains to a centrifuge including carriers which receive the adapter and to a method of using the adapter in a centrifuge to thaw contents of the flexible container.
    Type: Grant
    Filed: May 21, 2001
    Date of Patent: October 7, 2003
    Inventor: Carlos Guillermo Mesa
  • Publication number: 20030176267
    Abstract: The invention relates to a centrifuge provided with a blood bag system having an upper and lower outlet for separation of blood constituents, containing a rotor which can be driven in a rotative manner about a hub, wherein at least one conventional whole blood bag equipped with an upper outlet and with a lower outlet can be positioned vertically in this blood bag, while the whole blood bag can be arranged on the rotor in such a way that one outlet of the whole blood bag is bent in a radial direction, and the opposite outlet of the whole blood bag is bent in the other radial direction, so that the entire whole blood bag and the outlets thereof adopt an approximately Z- or S-shaped form in its functional position. In this case it is preferred that the upper outlet of the whole blood bag lie radially toward the interior and the lower outlet of the whole blood bag lie radially toward the exterior of the whole blood bag.
    Type: Application
    Filed: October 31, 2002
    Publication date: September 18, 2003
    Inventor: Gunter Eberle
  • Patent number: 6605223
    Abstract: An automated blood separation method and apparatus is described that allows for the separation of multiple units of blood simultaneously. The method and apparatus reliably and quickly separates blood into its components. An auto-balancing feature within the apparatus automatically preferably compensates for the changing state of imbalance, thereby eliminating the need for additional balancing steps during the separation process. The apparatus has a rotor into which a plurality of cassettes can be inserted. The cassettes have a number of sections for the containment of the whole blood and for the separated blood components, which are contained in disposable bags. The rotor is placed into a centrifuge assembly, and the blood components are then separated and transferred to the bags in the individual sections of the cassettes. Means for including secondary separation devices such as filters is included.
    Type: Grant
    Filed: October 22, 2001
    Date of Patent: August 12, 2003
    Assignee: MEDIcept, Inc.
    Inventors: Glen Jorgensen, Donald E. Barry
  • Patent number: 6596180
    Abstract: A centrifuge system for the formation of an autologous platelet gel wherein all of the blood components for the gel are derived from a patient to whom the gel is to be applied. First a platelet rich plasma and a platelet poor plasma are formed by centrifuging a quantity of anticoagulated whole blood that was previously drawn from the patient. The platelet rich plasma or platelet poor plasma is then automatically drawn out of the centrifuge bag and proportioned into separate chambers in a dispenser. The first portion is activated where a clot is formed and thrombin is obtained. The thrombin is then latter mixed with the second portion to obtain a platelet gel.
    Type: Grant
    Filed: April 9, 2001
    Date of Patent: July 22, 2003
    Assignee: Medtronic, Inc.
    Inventors: Robert F. Baugh, Lisa M. Lim, Julie S. Johnston, John G. Rivera, Victor D. Dolecek
  • Patent number: 6592507
    Abstract: A single use system and kit for producing blood platelet concentrates is described herein. In a preferred form, the kit includes a bag set in which compartments containing blood components are adjacent to to separate compartments which can be inflated to express the blood components after their separation by centrifuging.
    Type: Grant
    Filed: June 18, 2002
    Date of Patent: July 15, 2003
    Assignee: Implant Innovations, Inc.
    Inventors: Glen E. Jorgensen, Bruce Berckmans, III
  • Publication number: 20030054934
    Abstract: Methods and apparatus for concentrating and recovering pathogens from a fluid other than blood are disclosed. The method includes concentrating the pathogens contained in the fluid by continuously feeding the fluid through one or more flexible chamber(s) and subjecting the chamber(s) to centrifugal forces. The concentrated pathogens may be re-suspended by shaking the chamber(s).
    Type: Application
    Filed: November 1, 2002
    Publication date: March 20, 2003
    Inventors: Richard I. Brown, Kyungyoon Min
  • Publication number: 20020173415
    Abstract: An adapter for supporting a flexible container in a cylindrical cavity of centrifuge carrier. The adapter is of a size that can be received in the cavity and comprises a wall comprised of a flexible material. The wall comprises a first concave wall portion having a first curvature and a second wall portion having a second curvature that is lower than the first curvature. The first wall portion is concave with reference to the flexible container. The first wall portion and the second wall portion are diametrically opposed to each other so as to receive the flexible container in an interior region substantially bounded by an inner surface of the wall. The invention also pertains to a centrifuge including carriers which receive the adapter and to a method of using the adapter in a centrifuge to thaw contents of the flexible container.
    Type: Application
    Filed: May 21, 2001
    Publication date: November 21, 2002
    Inventor: Carlos Guillermo Mesa
  • Publication number: 20020151423
    Abstract: A single use system and kit for producing blood platelet concentrates is described herein. In a preferred form, the kit includes a bag set in which compartments containing blood components are adjacent to separate compartments which can be inflated to express the blood components after their separation by centrifuging.
    Type: Application
    Filed: June 18, 2002
    Publication date: October 17, 2002
    Inventors: Glen E. Jorgensen, Bruce Berckmans
  • Publication number: 20020082153
    Abstract: An automated blood separation method and apparatus is described that allows for the separation of multiple units of blood simultaneously. The method and apparatus reliably and quickly separates blood into its components. An auto-balancing feature within the apparatus automatically preferably compensates for the changing state of imbalance, thereby eliminating the need for additional balancing steps during the separation process. The apparatus has a rotor into which a plurality of cassettes can be inserted. The cassettes have a number of sections for the containment of the whole blood and for the separated blood components, which are contained in disposable bags. The rotor is placed into a centrifuge assembly, and the blood components are then separated and transferred to the bags in the individual sections of the cassettes. Means for including secondary separation devices such as filters is included.
    Type: Application
    Filed: October 22, 2001
    Publication date: June 27, 2002
    Inventors: Glen Jorgensen, Donald E. Barry
  • Patent number: 6350225
    Abstract: A container assembly having a support bridge to prevent centrifugal forces from collapsing the container. A lid is positioned on top of the container, and the support bridge is disposed between the lid and an upper portion of the container.
    Type: Grant
    Filed: June 29, 2000
    Date of Patent: February 26, 2002
    Assignee: Kendro Laboratory Products, L.P.
    Inventors: Edward Thomas Sheeran, William Andrew Romanauskas
  • Patent number: 6325750
    Abstract: A blood platelet collection system includes a bucket having wells 24, 26 adapted to receive a bag system therein. The bag system includes a pair of compartmented containers. Each container includes a collection bag 12, 16 and an adjacent inflatable bag 22, 28 and is preferably an integrated structure made of three sheets 52, 54, 56. After centrifugation, the inflatable bags are caused to expand, in turn, to transfer blood components between the collection bags via tube 14.
    Type: Grant
    Filed: March 15, 2000
    Date of Patent: December 4, 2001
    Assignee: Implant Innovations, Inc.
    Inventors: Glen E. Jorgensen, Bruce Berckmans, III
  • Patent number: 6019716
    Abstract: A device is provided for use in a centrifuge to separate or isolate material (such as pelleted cells, particulates, aggregates, compounds, blood components, and the like) from the liquid in which they are suspended while limiting or preventing loss of any of the resulting separated or pelleted material during further manipulations. The device can be inserted into a standard centrifugation bucket in a centrifuge and holds a flexible centrifuge bag. The device includes at least one damp assembly, which includes a partition that is maintained in an open position during centrifugation and in a closed position at unit gravity, thus isolating separated or pelleted material at the bottom of the flexible bag in the device after centrifugation and preventing the isolated material from being disturbed during liquid changes and other manipulations.
    Type: Grant
    Filed: July 13, 1998
    Date of Patent: February 1, 2000
    Assignee: Novartis AG
    Inventors: Sean Forestell, Robert J. Tushinski, Richard J. Rigg, Yakov Bobrov
  • Patent number: 5770069
    Abstract: A method and apparatus for sterile separation of a fluid into components, for washing of a material, and for preparing a washed, separated material for refrigerated storage includes rotating the fluid or material in a multi-chambered container to accomplish a centrifuging operation. An apparatus embodying the invention may include an elongated, collapsible container having plural chambers connected in series by necks. The multi-chambered container may be formed of a single flexible bag having plural chambers. Alternately, the container may comprise plural flexible bags, each of which comprises one or more of the chambers of the container. A chamber of the container may be separated into plural sections by partition walls, each of the sections of the chamber being connected to an adjacent chamber by a separate branch of a neck between the chambers.
    Type: Grant
    Filed: February 21, 1997
    Date of Patent: June 23, 1998
    Assignee: Organ, Inc.
    Inventor: Harold T. Meryman
  • Patent number: 5690602
    Abstract: A centrifuge comprising a yoke element that rotates about a rotational axis and a processing chamber having an axis. The processing chamber includes a bowl element, a spool element, and a mechanism for joining the spool and bowl elements for relative movement between a mutually cooperating position for centrifugal processing and a mutually separated position for loading. A hinge attaches the processing chamber to the yoke element for pivotal movement between an operating position and an access position. In the operating position, the spool and bowl elements are in their mutually cooperating position and oriented for rotation with the yoke element about the rotational axis. In the access position, the processing chamber axis lies outside the axis of rotation and the spool and bowl elements are oriented for movement from their mutually cooperating position into their mutually separated position.
    Type: Grant
    Filed: August 30, 1996
    Date of Patent: November 25, 1997
    Assignee: Baxter International Inc.
    Inventors: Richard I. Brown, Warren P. Williamson, Paul M. Di Perna
  • Patent number: 5549540
    Abstract: An insert nestingly receivable within a centrifuge cup to support a pair of fluid containing bags therein is formed from a pair of concave shapes having an upper end and a lower end and which are centrally adhered together in back-to-back relationship. The shapes together with an interior surface of the centrifuge cup together form a pair of elliptically shaped chambers for supporting a pair of the bags within the cup. A pair of pins extend through the concave shapes and extend outwardly therefrom. The bags each are provided with a pair of spaced-apart holes to receive the pins, thereby supporting the bags within the elliptically shaped chambers. Preferably a block is fitted between the adhered together surfaces of the shapes at each lateral edge at the lower ends thereof. These blocks preferably extend laterally outwardly beyond the lateral extremities of the shapes, and the edges of the concave shapes and the blocks are rounded to thereby be nestingly receivable in the interior of the cup.
    Type: Grant
    Filed: October 13, 1994
    Date of Patent: August 27, 1996
    Assignee: Baxter International Inc.
    Inventors: Glenn Moore, Caryl Ellis
  • Patent number: 5224921
    Abstract: A device and method are provided for separating mononuclear cells from red blood cell depleted plasma in a centrifuge blood cell separator. The device includes an inlet for receiving plasma, an area for receiving mononuclear cells, and an outlet for receiving mononuclear cell depleted plasma. The distance and flow path between the inlet and outlet being so constructed and arranged as to cause mononuclear cells to sediment out into the area for receiving the mononuclear cells and causing at least 66% of the platelets contained in the plasma to flow to and through the outlet.
    Type: Grant
    Filed: May 31, 1990
    Date of Patent: July 6, 1993
    Assignee: Baxter International Inc.
    Inventors: T. Michael Dennehey, Joseph C. West, Jr.
  • Patent number: 5110552
    Abstract: The apparatus of the invention includes a plurality of cartridges (1) each containing serum, and reagents in a sachet. The cartridges are inserted into the automatic processing device (40) enabling the serum to be put into contact with the various reagents and then enabling the results to be read.
    Type: Grant
    Filed: July 18, 1989
    Date of Patent: May 5, 1992
    Inventor: Jean Guigan
  • Patent number: 5092996
    Abstract: A closed blood filter system comprising a filter connected to at least one blood bag, the filter comprising a housing having peripheral support means adapted to hold the filter in place on top of a blood bag centrifuge bucket (cup) and above the blood bags during centrifugation of blood bag contents. In a preferred embodiment the filter is connected between two blood bags by blood bag tubing. A preferred filter housing is generally disk-like and includes an annular projection adapted to fit snugly on the shoulder of a cylindrical centrifuge bucket (cup) while allowing passage of a tubing connecting the top side of the filter with a blood bag held in the centrifuge cup and below the filter.
    Type: Grant
    Filed: February 19, 1991
    Date of Patent: March 3, 1992
    Assignee: Miles Inc.
    Inventor: Richard Spielberg
  • Patent number: 5061446
    Abstract: The device of the invention comprises a plurality of cartridges (1) containing serum, conjugate, substrate, blocking liquid, and a liquid-receiving well containing an antigen-carrying brush. A processing device (40) for simultaneously processing cartridges (1) considerably reduces the time required for the reaction compared with prior art devices.
    Type: Grant
    Filed: July 18, 1989
    Date of Patent: October 29, 1991
    Inventor: Jean Guigan
  • Patent number: 4909949
    Abstract: A bridge is attachable to and mountable upon the upper edge of a centrifuge cup for suspending a blood collection bag within the cavity of the centrifuge cup during centrifugation of the collected blood. The bridge includes structure for supporting the bridge upon an expressor to permit expressing the centrifuged blood from the bridge suspended blood collection bag.
    Type: Grant
    Filed: October 26, 1987
    Date of Patent: March 20, 1990
    Assignee: Engineering & Research Associates
    Inventors: Daniel C. Harmony, Bradley T. Noble
  • Patent number: 4892668
    Abstract: Isolation of a quantity of blood within a fold of a blood collection bag is prevented during centrifugation by applying a laterally oriented force against the blood collection bag to pressurize it and encourage unfolding of any folds. The laterally oriented force is generated by the apparent weight increase of the blood collection bag during centrifugation.
    Type: Grant
    Filed: October 5, 1988
    Date of Patent: January 9, 1990
    Assignee: Engineering & Research Associates, Inc.
    Inventors: Daniel C. Harmony, Bradley T. Noble
  • Patent number: 4753739
    Abstract: A blood bag support system is described which is very useful for supporting a blood bag in a centrifuge. The support system includes two upright support members and horizontal connecting means extending between the upright supports. A blood bag is suspended from the connecting means. The support system is balanced so as to avoid vortexing or mixing inside the blood bag during centrifuging. The support system holds up the ports at the top of the bag, enabling red blood cells in the ports to be forced downwardly during centrifuging. This prevents contamination of blood components with red blood cells.
    Type: Grant
    Filed: January 27, 1986
    Date of Patent: June 28, 1988
    Assignee: Engineering & Research Associates
    Inventor: Bradley T. Noble
  • Patent number: 4714457
    Abstract: In the preparation of concentrated fibrinogen extracted from the blood for making fibrin glue for use, e.g., as tissue adhesive or intra-arterial embolizing agent, the blood and subsequently obtained plasma are separated by centrifuging. In order to efficiently and rapidly prepare a small quantity of fibrinogen from a patient's own blood to be administered to the same patient during imminent surgery, an arrangement is disclosed wherein the blood or plasma to be centrifuged is transferred to a flat bag or packet which is then fitted into an insert fixture assembly which reliably secures the packet in the centrifuge cup in a suitable orientation.
    Type: Grant
    Filed: September 15, 1986
    Date of Patent: December 22, 1987
    Inventor: Robert Alterbaum
  • Patent number: 4683120
    Abstract: A biological fluid assay system and method for the determination of immunoreactive characteristics of biological specimen and more particularly for the qualitative determination of immunological reactions. The apparatus includes a centrifuge rotor, a disposable belt mountable on the centrifuge rotor, and a plurality of light transmissive chambers as components of the removable belt, each of the chambers having a vertical apex and a horizontal radial apex for accepting a sample comprising a specimen and an appropriate reagent. An illumination system projects an image of the sample while a linear photosensitive array detects the image of the sample for measuring the vertical dimension of the sample and a microprocessor analyzes the vertical dimension of the sample. A sample is radially accelerated to compress the particulate portion of the sample or reagent into a compact mass in the extreme radial portion of the transparent chamber.
    Type: Grant
    Filed: October 18, 1984
    Date of Patent: July 28, 1987
    Assignee: Gamma Biologicals, Inc.
    Inventors: Peter M. Meserol, Jesse L. Acker
  • Patent number: 4617009
    Abstract: Centrifugal batch separation of blood in a closed collapsible container is carried out by placing the container in a rigid casing in which the container is divided into two or more sections in that the casing constricts the container at one or more predetermined positions between the ends of the container. The casing with the container therein is then centrifuged, a gap-like passage between the container sections permitting rearrangement of the contents of the container so that each section will accommodate a blood fraction. After the centrifugation the fractions are isolated from each other. The volume of the cavity within the casing accommodating the radially outermost container section is matched with the hematocrit and the total blood volume by means of filler bodies.
    Type: Grant
    Filed: July 26, 1984
    Date of Patent: October 14, 1986
    Assignee: Seroteknik HG
    Inventors: L. Erik Ohlin, H. Peter Unger, J. Eric Westberg
  • Patent number: 4582606
    Abstract: Apparatus for separating or partitioning different density components of a liquid includes a liquid transfer pack composed of first and second flexible bags whose interiors are connected by tubing and a carrier for supporting the transfer pack. the carrier includes first and second sections defining first and second chambers for containing said first and second bags which sections can telescope between an extended condition wherein the volume of the second chamber is a maximum and a collapsed or retracted condition wherein the volume of the second chamber is a minimum. The two sections are biased toward their extended condition so that the first and second bags can be positioned in said chambers so that when the carrier and pack are spun at a selected high speed about an axis perpendicular to the carrier telescoping axis, the carrier sections will retract thereby maintaining the second bag in a collapsed condition in the second chamber minimum volume until the spinning slows to a selected lower speed.
    Type: Grant
    Filed: January 30, 1984
    Date of Patent: April 15, 1986
    Assignee: Neotech, Inc.
    Inventor: Read S. McCarty
  • Patent number: 4531932
    Abstract: The device comprises a single needle circuit having lines for admitting whole blood drawn from a patient to a continuously rotating rotor, re-introducing red cells and collecting plasma, the lines being respectively connected to the three outlets of a coupling static block rigidly attached to the rotor, two photocell-lightsource assemblies being further provided for automatically cyclically switching over the blood pick up and red cells introduction steps in the device steady state condition of operation.
    Type: Grant
    Filed: November 22, 1982
    Date of Patent: July 30, 1985
    Assignee: Dideco S.p.A.
    Inventors: Libero Luppi, Alessandro Calari
  • Patent number: 4493691
    Abstract: The device comprises a rotor formed with a circumferential groove including a widening with an apertured bottom whereat two monitoring stroboscopes are arranged, the groove being provided for engaging with the red cell and plasma exit end of a disposable bag, the other end whereof is so designed and arranged as to receive whole blood.
    Type: Grant
    Filed: March 14, 1983
    Date of Patent: January 15, 1985
    Assignee: Dideco S.P.A.
    Inventor: Alessandro Calari
  • Patent number: 4482342
    Abstract: A cell washing method and apparatus which utilizes centrifugation to separate blood components in a flexible bag. The less dense separated components e.g., supernatant, is expressed from the bag by centrifugal force acting on a plate adjacent the bag and the more dense component e.g., RBC's, remains. The bag is oriented at a double angle in the centrifuge so that less dense component accumulates at one location and more dense at a second location diagonally opposite the first location, thus facilitating removal of the less dense and washing of the more dense component.
    Type: Grant
    Filed: June 17, 1982
    Date of Patent: November 13, 1984
    Assignee: Haemonetics Corporation
    Inventors: Richard M. Lueptow, Jeffrey J. Peterson
  • Patent number: 4445883
    Abstract: A deformable support for a pressure plate blood processing centrifuge apparatus is described. A plate 50 is disposed adjacent a deformable support 10 having a recess for a flexible bag 8 in which blood is processed. Under the influence of centrifugal force the plate 50, which is disposed inwardly nearer the center of rotation than the bag 8, exerts a force against the support 10 and bag 8 and expels a separated blood component from the bag into a receiver container 6.The support 10 absorbs forces in the bag 8 thereby enabling the bag to be made of thin walled inexpensive material which would otherwise rupture under the separation forces. Yet the support 10 is sufficiently yielding to enable the pressure plate 50 to move and create an expelling force.
    Type: Grant
    Filed: January 18, 1982
    Date of Patent: May 1, 1984
    Assignee: Haemonetics Corporation
    Inventor: Donald W. Schroendorfer
  • Patent number: 4413773
    Abstract: A blood bag is described which aids in maintaining the separation of blood components. This bag is constructed of a flexible plastic, has a conical top leading to an outlet line and internal septa to reduce swirling of the bag's contents during rotor deceleration. The bag is adapted to be placed in a split sleeve prior to placement in the swinging bucket of a centrifuge rotor. A collar is placed over the top of the bag to aid in reducing wrinkles in the bag.Methods are described for reducing contamination of separated blood components by reducing bag wrinkles, reducing swirling of the blood fractions during rotor deceleration, and reducing mixing during expression.
    Type: Grant
    Filed: September 29, 1980
    Date of Patent: November 8, 1983
    Assignee: E. I. Du Pont de Nemours and Company
    Inventors: Vernon C. Rohde, William A. Romanauskas