Protein Patents (Class 502/403)
  • Patent number: 9125885
    Abstract: This invention provides a multivalent immunogenic composition including a soluble portion of a Mycoplasma hyopneumoniae (M. hyo) whole cell preparation; and a porcine circovirus type 2 (PCV2) antigen, wherein the soluble portion of the M. hyo preparation is substantially free of both (i) IgG and (ii) immunocomplexes comprised of antigen bound to immunoglobulin.
    Type: Grant
    Filed: March 26, 2013
    Date of Patent: September 8, 2015
    Assignee: Zoetis Services LLC
    Inventors: Gregory P. Nitzel, Jeffrey E. Galvin, John Keith Garrett, James R. Kulawik, II, Tracy L. Ricker, Megan Marie Smutzer
  • Patent number: 9125886
    Abstract: This invention provides a trivalent immunogenic composition including a soluble portion of a Mycoplasma hyopneumoniae (M.hyo) whole cell preparation; a porcine circovirus type 2 (PCV2) antigen; and a PRRS virus antigen, wherein the soluble portion of the M. hyo preparation is substantially free of both (i) IgG and (ii) immunocomplexes comprised of antigen bound to immunoglobulin.
    Type: Grant
    Filed: March 26, 2013
    Date of Patent: September 8, 2015
    Assignee: Zoetis Services LLC
    Inventors: Gregory P. Nitzel, Jeffrey E. Galvin, John Keith Garrett, James R. Kulawik, II, Tracy L. Ricker, Megan Marie Smutzer
  • Patent number: 9120859
    Abstract: This invention provides an immunogenic composition including a soluble portion of a Mycoplasma hyopneumoniae (M.hyo) whole cell preparation, wherein the soluble portion of the M.hyo preparation is substantially free of both (i) IgG and (ii) immunocomplexes comprised of antigen bound to immunoglobulin.
    Type: Grant
    Filed: March 26, 2013
    Date of Patent: September 1, 2015
    Assignee: Zoetis Services LLC
    Inventors: Jeffrey E. Galvin, Gregory P. Nitzel, John Keith Garrett, James R. Kulawik, Tracy L. Ricker, Megan Marie Smutzer
  • Publication number: 20150027953
    Abstract: The present invention discloses a silica particle having a diameter less than or equal to 2 ??, wherein the particle is spherical and comprises interconnected pores having a diameter in the range from 50 nm to 300 nm. The silica particle is preferably produced by spray pyrolysis (=spray drying) of a silica colloid. In the production process, porosity is introduced by means of an inorganic salt, such as NaCl, KCI, LiCl, NaNO3 or Ll NO3, which serves as a pore template. The silica particle may further be functionalized with proteins, peptides, nucleic acids, polysaccharides and proteoglycans, preferably concanavalin A or avidin. The present invention further discloses the use of the silica particle in chromatography, in particular in affinity chromatography.
    Type: Application
    Filed: January 9, 2013
    Publication date: January 29, 2015
    Inventors: Amanda K. Peterson Mann, Benjamin F. Mann, Sara E. Skrabalak, Milos V. Novotny
  • Publication number: 20150024931
    Abstract: In some embodiments, the present disclosure pertains to methods of capturing CO2 from an environment by associating the environment (e.g., a pressurized environment) with a porous carbon material that comprises a plurality of pores and a plurality of nucleophilic moieties. In some embodiments, the associating results in sorption of CO2 to the porous carbon materials. In some embodiments, the sorption of CO2 to the porous carbon materials occurs selectively over hydrocarbons in the environment. In some embodiments, the methods of the present disclosure also include a step of releasing captured CO2 from porous carbon materials. In some embodiments, the releasing occurs without any heating steps by decreasing environmental pressure. In some embodiments, the methods of the present disclosure also include a step of disposing released CO2 and reusing porous carbon materials. Additional embodiments of the present disclosure pertain to porous carbon materials that are used for CO2 capture.
    Type: Application
    Filed: June 26, 2014
    Publication date: January 22, 2015
    Applicant: William Marsh Rice University
    Inventors: James M. Tour, Chih-Chau Hwang, Josiah Tour
  • Publication number: 20140323697
    Abstract: The invention relates generally to solid supports for chromatography. In specific embodiments the invention provides for solid supports suitable for affinity chromatography along with methods, systems and kits which use the same.
    Type: Application
    Filed: July 7, 2014
    Publication date: October 30, 2014
    Inventors: Nanying Bian, Senthil Ramaswamy, Neil Soice, Chen Wang, Yuan Wong
  • Patent number: 8859726
    Abstract: The present invention relates to a method of separating one or more immunoglobulin containing proteins from a liquid. The method includes first contacting the liquid with a separation matrix comprising ligands immobilised to a support; allowing the immunoglobulin containing proteins to adsorb to the matrix by interaction with the ligands; followed by an optional step of washing the adsorbed immunoglobulin containing proteins; and recovering said immunoglobulin containing proteins by contacting the matrix with an eluent which releases the proteins. The method improves upon previous separation methods in that each of the ligands comprises one or more of a protein A domain (E, D, A, B, C), or protein Z, or a functional variant thereof, with at least one of the monomers having a substitution of the C-terminal most proline residue after the third alpha-helix.
    Type: Grant
    Filed: November 28, 2011
    Date of Patent: October 14, 2014
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Tomas Bjorkman, Gustav Rodrigo
  • Publication number: 20140235435
    Abstract: To provide an affinity carrier with a low pressure loss and a large binding capacity even when the linear flow rate of a solution to be made to pass therethrough is high. Silica spheres, which satisfy the following conditions: (a) the average particle size is from 30 ?m to 40 ?m as measured by a laser light scattering method; (b) the ratio (D10/D90) of the particle size (D10) of smaller 10% cumulative volume to the particle size (D90) of 90% cumulative volume in a particle size distribution as measured by a Coulter counter method, is at most 1.50; and (c) the average pore size is from 85 nm to 115 nm and the pore volume is at least 1.5 mL/g, as measured by a mercury intrusion technique.
    Type: Application
    Filed: April 25, 2014
    Publication date: August 21, 2014
    Applicant: AGC SI-TECH CO., LTD.
    Inventors: Hiroyoshi MIYAHARA, Ryou NAKASHIMA, Kenji HIGASHI
  • Patent number: 8728320
    Abstract: This invention relates to a lignin sorbent, a lignin removal unit, a biorefinery, a process for removing lignin, a process for binding lignin, and a renewable material. The lignin sorbent includes a substrate, and a lignin binding material dispersed with respect to the substrate. The lignin binding process includes the step of adding a lignin binding material to an input stream, and the step of converting the input stream into a renewable material.
    Type: Grant
    Filed: June 25, 2009
    Date of Patent: May 20, 2014
    Assignee: BP Corporation North America Inc.
    Inventor: Jacob Borden
  • Patent number: 8562905
    Abstract: In one aspect, the present invention provides a method of forming a film of nanocomposites of carbon nanotubes (CNTs) and platinum (Pt) nanoparticles. In one embodiment, the method includes the steps of (a) providing a first solution that contains a plurality of CNTs, (b) providing a second solution that contains a plurality of Pt nanoparticles, (c) combining the first solution and the second solution to form a third solution, and (d) filtering the third solution through a nanoporous membrane using vacuum filtration to obtain a film of nanocomposites of CNTs and Pt nanoparticles.
    Type: Grant
    Filed: September 8, 2010
    Date of Patent: October 22, 2013
    Assignee: Northwestern University
    Inventors: Mark C. Hersam, Gordana Ostojic, Yu Teng Liang
  • Publication number: 20130209312
    Abstract: A multilayer film may include a polymeric film layer and an absorbing layer on a side of the polymeric film layer. The absorbing layer may be adapted to absorb an odor, a volatile organic compound, or both. The absorbing layer may include a palladium complex and at least one of a cyclodextrin, a hydrophobin protein, and a derivative thereof.
    Type: Application
    Filed: February 13, 2012
    Publication date: August 15, 2013
    Applicant: Morgan Adhesives Company
    Inventors: Olivier Jacques Dupuis, Carine Gabrièle Lefevre, Jean-Christophe Fernand Minor
  • Patent number: 8435336
    Abstract: A deoxidizer includes a porous body of fluorite-type cerium oxide represented by CeOx (where x is a positive number smaller than 2) and having a reversible oxygen deficiency. The deoxidizer has a specific surface area of 0.6 to 1.8 m2/g and a pore median diameter of 1.6 to 5.3 ?m. The cerium oxide used for the deoxidizer is produced by: firing a cerium-containing salt in the atmosphere at 500° C. to 1400° C. for 1 to 20 hours, to produce fluorite-type cerium oxide composed of a porous body; and firing the cerium oxide at 700° C. to 1100° C. for 1 to 3 hours in a reducing atmosphere having a hydrogen concentration equal to or above the lower explosive limit, to remove oxygen from the cerium oxide and produce the fluorite-type cerium oxide represented by CeOx and having a reversible oxygen deficiency.
    Type: Grant
    Filed: July 6, 2009
    Date of Patent: May 7, 2013
    Assignee: Mitsui Mining & Smelting Co., Ltd.
    Inventors: Kazuya Kinoshita, Yuichi Senoo, Yousuke Shibata, Isamu Yashima
  • Patent number: 8394350
    Abstract: A method for separating CO2 from gas mixtures uses a slurried media impregnated with buffer compounds and coating the solid media with a catalyst or enzyme that promotes the transformation of CO2 to carbonic acid. Buffer sorbent pebbles with a catalyst or enzyme coating are provided for rapid separation of CO2 from gas mixtures.
    Type: Grant
    Filed: May 19, 2010
    Date of Patent: March 12, 2013
    Assignee: Lawrence Livermore National Security, LLC
    Inventor: Roger D. Aines
  • Publication number: 20120226054
    Abstract: The present invention generally provides a separation matrix comprising at least two stationary phases and a stationary phase comprising at least one chiral modality and at least one achiral modality. Also provided are methods of using the separation matrix or the stationary phase to separate enantiomers of one or more chiral molecules.
    Type: Application
    Filed: March 3, 2011
    Publication date: September 6, 2012
    Applicant: BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS
    Inventors: Grover Miller, Drew R. Jones, Gunnar Boysen
  • Patent number: 8148501
    Abstract: Absorbent hydrogels are formed by reacting a protein meal base, a radical initiator and a polymerizable monomer. Optionally, a cross-linking agent and/or a radical accelerant, such as tetramethylethylenediamine (TMEDA) or sodium bisulfite (NaHSO3), is also added to the mixture. Preferably, the radical initiator is ammonium persulfate (APS) or potassium persulfate (KPS), and the cross-linking agent is preferably trifunctional trimethylolpropane trimethacrylate (TMPTMA) or methylene bis acrylamide (MBA). The polymerizable monomer is preferably acrylic acid, or a combination of acrylic acid and acrylamide. The as-formed hydrogel is washed in order to extract non-reactant components from the gel and then dried. The resultant absorbent and superabsorbent hydrogels have high water uptake ratios, and can be utilized for a variety of applications.
    Type: Grant
    Filed: February 23, 2009
    Date of Patent: April 3, 2012
    Assignee: Battelle Memorial Institute
    Inventors: Herman P. Benecke, Bhima R. Vijayendran, Kevin B. Spahr
  • Publication number: 20120055860
    Abstract: The present invention provides novel chromatographic materials, e.g., for chromatographic separations, processes for their preparation and separations devices containing the chromatographic materials. The preparation of the inorganic/organic hybrid materials of the invention wherein a surrounding material is condensed on a porous hybrid core material will allow for families of different hybrid packing materials to be prepared from a single core hybrid material. Differences in hydrophobicity, ion-exchange capacity, surface charge or silanol activity of the surrounding material may be used for unique chromatographic separations of small molecules, carbohydrates, antibodies, whole proteins, peptides, and/or DNA.
    Type: Application
    Filed: June 1, 2010
    Publication date: March 8, 2012
    Applicant: Waters Technologies Corporation
    Inventor: Kevin D. Wyndham
  • Publication number: 20110278500
    Abstract: A multi-component synergistic absorbent composition includes at least one polysaccharide and at least one or more polysaccharide-based components or gelling proteins. This composition possesses synergistic effects in its capacity to absorb water, saline solutions and biological fluids, at normal pressure or under load, or to retain these fluids, or a combination of these properties.
    Type: Application
    Filed: July 25, 2011
    Publication date: November 17, 2011
    Inventor: David Bergeron
  • Publication number: 20110212830
    Abstract: A dry product that permanently removes oil and oil stains from liquid or dry surfaces and is environmentally safe. The dry product is formed by mixing efficacious proportions of untreated amorphous silica with a dry, inert organic, inorganic or synthetic carrier, or combinations of said carriers. Suitable inert carriers include, but are not limited to, (a) inert inorganic carriers including, but not limited to, clays, perlite, vermiculite, crushed glass, volcanic ash and sand; (b) inert organic carriers, including, but not limited to, peat moss, straw, hay, sawdust, ground corncobs, flours, and coconut coir, and (c) inert synthetic carriers, including, but not limited to, polyurethane, polyethylene and polypropylene. The dry product can be applied directly to oil stains either on a hard surface, such as concrete or asphalt, or to oil spills on water.
    Type: Application
    Filed: April 5, 2011
    Publication date: September 1, 2011
    Applicant: Rousseau Research, Inc.
    Inventor: Joseph D. Russo
  • Publication number: 20110201085
    Abstract: The present disclosure describes an adsorbent and exemplary protocols for extracting nucleic acids, such as DNA and RNA, from complex matrices, such as stool samples and water samples. The adsorbent is activated charcoal coated with a material such as polyvinylpyrrolidone, dextran, or coconut flours. The adsorbent may be used in microcentrifuge spin columns, where it may be present as a slurry in a storage solution. The sample may be prepared by vortexing in a buffer solution, centrifuging, adding a protease to the supernatant, and passing the supernatant through a microcentrifuge spin column containing coated activated charcoal. The key components, including buffer, protease, and spin columns, may be packaged in a kit.
    Type: Application
    Filed: February 16, 2011
    Publication date: August 18, 2011
    Applicant: Phthisis Diagnostics Corporation
    Inventors: Crystal R. ICENHOUR, Brian V. Loyal, Linh H.K. Nguyen
  • Patent number: 7964559
    Abstract: The present invention relates, e.g., to an isolated polypeptide from a cyanobacterium, Microcystis viridis, which binds specifically to an oligosaccharide comprising the tetrasaccharide Man-alpha-(1?6)Man-beta (1?4) GlcNAc-beta(1?4)GlcNAc. The polypeptide can be obtained, for example, from a cell that expresses a recombinant nucleic acid that encodes a MVL-like polypeptide. The invention also relates to an isolated polypeptide comprising one or more copies of the sequence GPLWSNXEAQXXGPX (SEQ ID NO: 1) and/or one or more copies of the sequence FTGQWXTXVEXXMSV (SEQ ID NO: 2), wherein the polypeptide binds specifically to the above-mentioned oligosaccharide. Conjugates comprising such polypeptides and an effector molecule are also disclosed, as are methods of using such polypeptides or conjugates, e.g., for inhibiting infection by a virus, such as HIV, or for removing a virus, such as HIV, from a sample, such as a bodily fluid or an inanimate object.
    Type: Grant
    Filed: March 9, 2005
    Date of Patent: June 21, 2011
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventor: Carole A. Bewley
  • Publication number: 20110117596
    Abstract: A composite sorbent material is disclosed which comprises A) a housing of a dense, insoluble material having openings therein and B) a porous polymer gel housed within said housing, said housing being provided with openings therein for fluid communication between said porous monolithic polymer gel and the surroundings, and said porous monolithic polymer gel occupying the inner space of said housing and being kept on place within said housing by mechanical means. Processes for the preparation of composite sorbent materials by cryoprecipitation are also disclosed as well as the use of the composite sorbent material according to the invention e.g. for the removal of pollutants from gases or liquids, for the enrichment or separation of molecules and for cell culture.
    Type: Application
    Filed: March 20, 2007
    Publication date: May 19, 2011
    Inventors: Bo Mattiasson, Fatima Plieva
  • Publication number: 20110117149
    Abstract: Discloses are stabilized calcium pyrophosphate nanotubes, a process for making calcium pyrophosphate nanotubes comprising agitating at less than 2 OkHz an aqueous suspension of a calcium and a phosphate for a time sufficient to precipitate said inorganic calcium pyrophosphate nanotubes, and uses thereof.
    Type: Application
    Filed: July 2, 2009
    Publication date: May 19, 2011
    Applicant: Nanunanu Ltd.
    Inventor: Jake Barralet
  • Publication number: 20110082421
    Abstract: The invention discloses compositions of matter and methods of using such compositions to detoxify blood and blood products. The invention as particular use in the treatment of diabetes, Alzheimer's disease, hemodialysis associated amyloidosis, and cardiovascular complications.
    Type: Application
    Filed: February 7, 2007
    Publication date: April 7, 2011
    Inventors: Guillermo A. Ameer, Cynthia M. Daniels, Stuart M. Sprague
  • Publication number: 20110071227
    Abstract: The present invention relates to a method for the production of a quickly wettable material containing natural hydrocolloid in the form of a shaped body, in which a material containing natural hydrocolloid in the form of a shaped body is exposed to a plasma.
    Type: Application
    Filed: October 4, 2010
    Publication date: March 24, 2011
    Applicant: GELITA AG
    Inventors: Michael Ahlers, Steffen Oesser, Michael Grzinia, Klaus Flechsenhar
  • Publication number: 20110028315
    Abstract: Peptides have been generated that have binding affinity to carbon nanostructures and particularly carbon nanotubes. Peptides of or the invention are generally about twelve amino acids in length. Methods for generating carbon nanotube binding peptides are also disclosed.
    Type: Application
    Filed: October 1, 2010
    Publication date: February 3, 2011
    Applicant: E. I. DU PONT DE NEMOURS AND COMPANY
    Inventors: ANAND JAGOTA, STEVEN RAYMOND LUSTIG, SIQUN WANG, HONG WANG
  • Publication number: 20110028316
    Abstract: Peptides have been generated that have binding affinity to carbon nanostructures and particularly carbon nanotubes. Peptides of or the invention are generally about twelve amino acids in length. Methods for generating carbon nanotube binding peptides are also disclosed.
    Type: Application
    Filed: October 1, 2010
    Publication date: February 3, 2011
    Applicant: E. I. Du Pont De Nemours and Company
    Inventors: Anand JAGOTA, Steven Raymond Lustig, Siqun Wang, Hong Wang
  • Publication number: 20110021348
    Abstract: Peptides have been generated that have binding affinity to carbon nanostructures and particularly carbon nanotubes. Peptides of or the invention are generally about twelve amino acids in length. Methods for generating carbon nanotube binding peptides are also disclosed.
    Type: Application
    Filed: October 1, 2010
    Publication date: January 27, 2011
    Applicant: E. I. DU PONT DE NEMOURS AND COMPANY
    Inventors: ANAND JAGOTA, STEVEN RAYMOND LUSTIG, SIQUN WANG, HONG WANG
  • Publication number: 20110021347
    Abstract: The present invention provides a new molecular recognition material, wherein the control of morphology is possible and the selectivity and capture efficiency of the template molecule are excellent, and to provide a simple production method thereof. The molecular recognition material of the present invention is a core-shell particle, which has a shell layer on the core particle surface, and the material is characterized in that template molecules are imprinted on the above-described shell layer. And a production method of the molecular recognition material of the present invention comprising: (a) introducing an iniferter group on the core particle surface, (b) adsorbing the template molecule, after process (a), onto the core particle surface, and (c) forming the shell layer, after process (b), on the core particle surface.
    Type: Application
    Filed: August 29, 2008
    Publication date: January 27, 2011
    Applicants: KEIO UNIVERSITY, SHISEIDO COMPANY LTD.
    Inventors: Hiroshi Ugajin, Haruma Kawaguchi, Norio Ueno
  • Publication number: 20100331560
    Abstract: This invention relates to a lignin sorbent, a lignin removal unit, a biorefinery, a process for removing lignin, a process for binding lignin, and a renewable material. The lignin sorbent includes a substrate, and a lignin binding material dispersed with respect to the substrate. The lignin binding process includes the step of adding a lignin binding material to an input stream, and the step of converting the input stream into a renewable material.
    Type: Application
    Filed: June 25, 2009
    Publication date: December 30, 2010
    Applicant: BP Corporation North America Inc.
    Inventor: JACOB BORDEN
  • Publication number: 20100276373
    Abstract: A device for the removal of heavy metals and heavy metal complexes, such as thimerosal, from medications is provided wherein the device comprises a solid support having at least one substantially purified metallothionein protein associated therewith.
    Type: Application
    Filed: June 21, 2010
    Publication date: November 4, 2010
    Inventors: Roger A. Acey, Richard Clinton Kanner
  • Publication number: 20100269758
    Abstract: The invention relates to a method for manufacturing an absorbent material from at least one plant raw material and an absorbent material manufactured by this method. The invention further relates to uses of the absorbent material and an apparatus having at least one device for grinding grains. The method according to the invention comprises the following steps: grinding whole cereal grains; extruding the ground cereal grains into spheres; and grinding the spheres to form absorbent material. Overall, an independently clumping absorbent material is produced via the method according to the invention from purely plant raw materials, by which liquids to be disposed of, such as, for example, oils, solvents, animal excrement or similar can be bound very rapidly and with high capacity.
    Type: Application
    Filed: June 27, 2008
    Publication date: October 28, 2010
    Applicant: AGROS TRADING GMBH
    Inventor: Klaus Fuchshuber
  • Patent number: 7816301
    Abstract: The present invention provides an aqueous-liquid-absorbing agent which comprises water-absorbent resin particles as essential components and is suitable for uses in sanitary materials. The aqueous-liquid-absorbing agent according to the present invention is an aqueous-liquid-absorbing agent comprising water-absorbent resin particles as essential components, wherein the water-absorbent resin particles are obtained by a process including the step of polymerizing a water-soluble ethylenically unsaturated monomer having a carboxyl group, and have a crosslinked structure in their inside, the aqueous-liquid-absorbing agent exhibiting a water absorption capacity (CRC) of 5 to 25 g/g and a saline flow conductivity (SFC) of not less than 1216 cm3·s·10?7/g.
    Type: Grant
    Filed: September 25, 2006
    Date of Patent: October 19, 2010
    Assignee: Nippon Shokubai Co., Ltd.
    Inventors: Hiroyuki Ikeuchi, Shigeru Sakamoto, Sayaka Machida
  • Patent number: 7759286
    Abstract: The invention is a system and method for containing a spill of petroleum product. The system includes a combination of ground rubber, beeswax, and ground corn cobs, which is then tossed into an area of a spill, then allowed to remain for a period until a substantial amount of the spilt petrol is adsorbed. Once this period expires, the adsorbed combination can be removed.
    Type: Grant
    Filed: May 4, 2009
    Date of Patent: July 20, 2010
    Assignee: Ameret, LLC
    Inventor: Charles T Chick
  • Publication number: 20100173376
    Abstract: A method of functionalizing carbon nanotubes with metallic moieties is disclosed. Carbon nanotubes are first associated with one or more binding moieties to provide carbon nanotubes encapsulated by the binding moieties. The encapsulated carbon nanotubes are then contacted with a metal salt or a metal complex that binds to the binding moieties. Reduction of the metal salt or metal complex provides carbon nanotubes functionalized with metal nanoparticles.
    Type: Application
    Filed: July 7, 2009
    Publication date: July 8, 2010
    Inventors: Gordana Ostojic, Mark C. Hersam
  • Publication number: 20100160605
    Abstract: To provide a novel packing material for liquid chromatography capable of separating and purifying, or collecting and recovering, a biopolymer such as a protein or a peptide by adsorption and desorption by a pH change without being influenced by the isoelectric point of the protein or by the salt concentration in a solvent in which the biopolymer such as the protein is dissolved, and to provide a process for concentrating and recovering a desired biopolymer such as a protein or a peptide from a large amount of dilute cell culture solution by means of such a packing material.
    Type: Application
    Filed: December 17, 2009
    Publication date: June 24, 2010
    Applicant: TOSOH CORPORATION
    Inventors: Katsuo KOMIYA, Koji NAKAMURA
  • Publication number: 20100048876
    Abstract: The present invention relates to a chromatography ligand, which comprises Domain C from Staphylococcus protein A (SpA), or a functional fragment or variant thereof. The chromatography ligand presents an advantageous capability of withstanding harsh cleaning in place (CIP) conditions, and is capable of binding Fab fragments of antibodies. The ligand may be provided with a terminal coupling group, such as arginine or cysteine, to facilitate its coupling to an insoluble carrier such as beads or a membrane. The invention also relates to a process of using the ligand in isolation of antibodies, and to a purification protocol which may include washing steps and/or regeneration with alkali.
    Type: Application
    Filed: September 27, 2007
    Publication date: February 25, 2010
    Inventors: Martin Hall, Sture Larsson, Andreas Muranyi, Gustav Rodrigo, Jinyu Zou, Per-Mikael Aberg
  • Publication number: 20090215619
    Abstract: Absorbent hydrogels are formed from soy protein isolate. More specifically, an absorbent hydrogel is formed by contacting soy protein isolate with urea to produce solubilized soy protein isolate which is combined with 2-mercaptoethanol to form a first mixture. The first mixture is heated and combined with a polymerizable monomer and ammonium persulfate to form a second mixture. The second mixture is then heated, followed by removal of the hydrogel from the second mixture. Optionally, the as-formed hydrogel may be subjected to a washing process to extract non-reactant components from the gel and then dried.
    Type: Application
    Filed: February 23, 2009
    Publication date: August 27, 2009
    Applicant: BATTELLE MEMORIAL INSTITUTE
    Inventors: Herman P. Benecke, Bhima R. Vijayendran, Kevin B. Spahr
  • Publication number: 20090192037
    Abstract: The invention relates to an adsorption filter material (1) that provides protection against chemical toxins, chemical weapons and pollutants, with a preferably multi-layer composite construction (2). The layer construction (2) includes at least one planar support layer (3) with two opposing sides (3?, 3?) and an adsorption layer (4), provided on the support layer (3) made from a material which adsorbs chemical toxins, the surface of at least one of the both sides (3? and/or 3?) of the support layer (3) being modified by plasma treatment. The surface properties, in particular the surface finish and the surface reactivity can be adjusted and optimised to match the application by means of the plasma treatment.
    Type: Application
    Filed: April 7, 2009
    Publication date: July 30, 2009
    Inventors: Bertram Bohringer, Tomas Stoll, Peter Heinrich, Michael Moskopp
  • Publication number: 20090087346
    Abstract: Capture particles for harvesting analytes from solution and methods for using them are described. The capture particles are made up of a polymeric matrix having pore size that allows for the analytes to enter the capture particles. The pore size of the capture particles are changeable upon application of a stimulus to the particles, allowing the pore size of the particles to be changed so that analytes of interest remain sequestered inside the particles. The polymeric matrix of the capture particles are made of co-polymeric materials having a structural monomer and an affinity monomer, the affinity monomer having properties that attract the analyte to the capture particle. The capture particles may be used to isolate and identify analytes present in a mixture. They may also be used to protect analytes which are typically subject to degradation upon harvesting and to concentrate low an analyte in low abundance in a fluid.
    Type: Application
    Filed: August 19, 2008
    Publication date: April 2, 2009
    Inventors: Alessandra Luchini, Lance Liotta, Emanuel Petricoin, Barney Bishop, Francesco Meani, Claudia Fredolini, Thomas M. Dunlap, Alexis Patanarut
  • Publication number: 20080132679
    Abstract: The present invention relates to a peptide excellently capable of binding to a protein capable of binding to insulin (IBP), an adsorbent comprising the aforementioned peptide immobilized on a carrier, an adsorber comprising the aforementioned adsorbent, and a method of adsorbing IBPs by using the aforementioned adsorbent or adsorber. The peptide, adsorbent, adsorber and method provided by the present invention can selectively adsorb and remove IBPs efficiently, and therefore be used, for example, in the treatment of diseases, typically diabetes, in which such IBP acts as an aggravating factor.
    Type: Application
    Filed: August 9, 2005
    Publication date: June 5, 2008
    Applicant: KANEKA CORPORATION
    Inventors: Ai Yonezawa, Souichi Morikawa, Eiji Ogino
  • Patent number: 7183336
    Abstract: Polymer particles are irradiated with radiation from a high energy source to increase the water or other fluid absorbency of the particles. Products manufactured using the activated particles include protective undergarments, bandages, kitty litter, and spill clean up materials.
    Type: Grant
    Filed: July 30, 2003
    Date of Patent: February 27, 2007
    Assignee: Super Absorbent Company
    Inventors: Phillip Berlin, Mark Sinkinson
  • Patent number: 7052609
    Abstract: The present invention relates to the regeneration of adsorbent matrices that are used for the purification of substances from aqueous liquid samples derived from biological material. The method is adapted to adsorbent matrices that are sensitive to hydrolysis either because of a sensitive base matrix or a sensitive ligand including also a sensitive spacer and is characterized in contacting at least one regeneration solution with the adsorbent matrix which comprises an organic solvent which is water-miscible and has a pH value ?4, preferably ?3 (acid solution) or ?10 but <13 (alkaline solution).
    Type: Grant
    Filed: August 11, 2004
    Date of Patent: May 30, 2006
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Gabriele Braunger, Jan Feuser, Joachim Walter
  • Patent number: 6875254
    Abstract: Methods for detecting gold and quantitating gold in ore samples utilizing a gold-specific protein are provided, including methods for multiple sample handling. Also provided are methods for extracting gold from mineral suspensions utilizing a magnetic mineral binding reagent and gold-specific protein, or hydrophobic reagent and gold-specific protein in conjunction with a flotation reagent.
    Type: Grant
    Filed: February 3, 2004
    Date of Patent: April 5, 2005
    Assignees: University of Washington, Placer Dome, Inc.
    Inventors: Clement E. Furlong, Scott Jorgenson-Soelberg, James B. Clendenning, Noel W. Kirshenbaum, Victor Chevillon, Peter Leon Kowalczyk
  • Patent number: 6774082
    Abstract: The compositions of the present invention comprise one or more palladium bound ligands that are covalently bonded to inorganic or organic solid supports. These palladium bound ligands bonded to solid supports can be used for single heterocyclic amine base separation, or can be used to separate nucleotide chain containing specific sequences from other nucleotides or nucleotide chains. In one aspect of the invention, each ligand present is individually complexed to a single Pd(II) ion. If there are from 2 to 4 ligands present in the composition, then each ligand present must be separated from the other ligands by at least 3 atoms, preferably from 3 to 20 carbon atoms or equivalent spacing.
    Type: Grant
    Filed: May 10, 2002
    Date of Patent: August 10, 2004
    Assignee: IBC Advanced Technologies, Inc.
    Inventors: Ronald L. Bruening, Krzysztof E. Krakowiak, David Vernell Dearden, Barry L. Haymore, Milton Bruening
  • Patent number: 6686202
    Abstract: Methods for detecting gold and quantitating gold in ore samples utilizing a gold-specific protein are provided, including methods for multiple sample handling. Also provided are methods for extracting gold from mineral suspensions utilizing a magnetic mineral binding reagent and gold-specific protein, or hydrophobic reagent and gold-specific protein in conjunction with a flotation reagent.
    Type: Grant
    Filed: August 8, 2001
    Date of Patent: February 3, 2004
    Assignees: Placer Dome, Inc., University of Washington
    Inventors: Clement E. Furlong, Scott Jorgenson-Soelberg, James B. Clendenning, Noel W. Kirshenbaum, Victor Chevillon, Peter Leon Kowalczyk
  • Publication number: 20030186807
    Abstract: The present invention relates to a hydrogel product for adsorption purposes where an in water insoluble support matrix is cross-linked with polymers which give rise to an in water swellable adsorbent. Further the polymers are internally cross-linked through at least one cross-linking agent. As a support matrix an organic polymer is used or a combination of such; e.g. polysaccharide such as agar, cellulose, starch and so on, protein and components of protein and polysaccharide. The support matrix is substituted with a first, soluble polymer material chemically bound to the support matrix, whereupon additional polymer materials optionally are built-in in the primary synthesised support matrix complex through different kinds of cross-links, wherein optionally the support matrix is present in the form of an acid- and base-stable residue.
    Type: Application
    Filed: May 28, 2003
    Publication date: October 2, 2003
    Inventors: Jerker Porath, Bo Ersson
  • Patent number: 6610630
    Abstract: A pseudobioaffinity chromatography adsorbent adapted for use in selectively adsorbing immunoglobulins. In one embodiment, the adsorbent includes: (a) a solid support material; and (b) a ligand immobilized on the surface of the solid support material, said ligand being a compound of the formula wherein Y1 is selected from the group consisting of S, SCH3+, O, NH, NCH3, CH2 and CR1R2 wherein at least one of R1 and R2 is not hydrogen; wherein each of Y2, Y3 and Y4 is selected from the group consisting of N, NCH3+, CH, and CR wherein R is not hydrogen; and wherein at least two of Y1, Y2, Y3 and Y4 are neither CH2, CH, CR nor CR1R2.
    Type: Grant
    Filed: February 13, 1998
    Date of Patent: August 26, 2003
    Assignee: Ciphergen Biosystems, Inc.
    Inventors: Alexander Schwarz, Meir Wilchek
  • Publication number: 20020164644
    Abstract: An adsorbent of high-mobility-group proteins (HMG protein) which can remove HMG protein in body fluid is disclosed. The adsorbent according to the present invention comprises a water-insoluble carrier on which (a) substance(s) having (a) hydrogen-bondable functional group(s) and/or (a) hydrophobic functional group(s) is(are) immobilized.
    Type: Application
    Filed: March 28, 2002
    Publication date: November 7, 2002
    Inventors: Ikuro Maruyama, Nobuo Ida, Sanae Masuko
  • Patent number: 6414096
    Abstract: Olefins of the formula R11—CH═CH—R12 (R11, R12=H or C1-C14-alkyl) are polymerized in the presence of a catalyst consisting of at least one metallocene of the formula I (M=zirconium or hafnium) and an aluminoxane. Polymers having a high molecular weight are obtained in a high yield.
    Type: Grant
    Filed: April 7, 1995
    Date of Patent: July 2, 2002
    Assignee: Basell Polyolefine GmbH
    Inventors: Volker Dolle, Martin Antberg, Jürgen Rohrmann, Walter Spaleck, Andreas Winter
  • Patent number: 6309999
    Abstract: A process for the preparation of an immunoadsorbent matrix includes preparing polyvinyl alcohol beads by partially crosslinking polyvinyl alcohol (PVA) with a crosslinking agent to provide polyvinyl alcohol beads which are at least partially crosslinked; coupling phenylalanine onto the polyvinyl alcohol beads to obtain a —COOH functionality for the phenylalanine coupled polyvinyl alcohol beads; and activating the —COOH functionality for immobilizing heparin onto the phenylalanine coupled polyvinyl alcohol beads.
    Type: Grant
    Filed: March 19, 1999
    Date of Patent: October 30, 2001
    Inventors: Chandra P. Sharma, P. R. Hari, Willi Paul