Library Containing Only Inorganic Compounds Or Inorganic Materials Patents (Class 506/22)
  • Patent number: 9126175
    Abstract: The disclosure relates to compositions, devices and methods for screening of photocatalysts for water-splitting.
    Type: Grant
    Filed: August 12, 2009
    Date of Patent: September 8, 2015
    Assignee: California Institute of Technology
    Inventors: Nathan S. Lewis, Jordan Katz, Todd Gingrich
  • Publication number: 20150141293
    Abstract: The invention provides a method for increasing the order of an array of polymeric micelles or of nanoparticles on a substrate surface comprising a) providing an ordered array of micelles or nanoparticles coated with a polymer shell on a substrate surface and b) annealing the array of micelles or nanoparticles by ultrasonication in a liquid medium which is selected from the group comprising H2O, a polar organic solvent and a mixture of H2O and a polar organic solvent. In a related aspect, the invention provides the highly ordered arrays of micelles or nanoparticles obtainable by the methods of the invention.
    Type: Application
    Filed: May 15, 2013
    Publication date: May 21, 2015
    Inventors: Christian Williges, Christoph Morhard, Joachim P. Spatz, Robert B. Brunner
  • Publication number: 20150126409
    Abstract: The present invention relates to the detection of microbial organisms using non-toxic nanostructured sensors that change their physical or chemical properties upon detecting these microbial organisms. These sensors allow an unskilled person to rapidly detect the presence of microbial contamination.
    Type: Application
    Filed: November 3, 2014
    Publication date: May 7, 2015
    Inventors: Khashayar Ghandi, Zahid Mahimwalla, Tan Yang, Cody Landry
  • Patent number: 8791053
    Abstract: The invention relates to a spatially encoded polymer matrix in the form of a bead or a granule for combinatorial solid phase synthesis, assaying, functional proteomics and diagnostic use. Compositions of such beads or granules are also provided. Each beaded polymer matrix of the composition comprises a plurality of spatially immobilized particles. The spatial immobilization of the particles confers on each beaded polymer matrix a “fingerprint” which enables identification of unique beads in a population of beads. The unique identification of individual beads makes it possible to perform combinatorial chemistry strategies while logging individual chemical transformation. Also provided are methods for detection of relative positions in space of particles, methods for generating matrices, methods for distance matrix determination, methods for identifying individual matrices and devices for recording and storing images of matrices.
    Type: Grant
    Filed: September 26, 2003
    Date of Patent: July 29, 2014
    Assignee: MPM-Holding APS
    Inventors: Soren Flygenring Christensen, Jens Hog Truelsen, Morten Meldal, Roice Michael, Ib Johannsen
  • Publication number: 20140121117
    Abstract: In a mass cytometer system, a tissue sample labeled with multiple metal tags is supported on an encoded substrate for distribution profile mapping by laser ablation. Groups of elemental ions from each plume generated by each laser pulse are detected by the mass cytometer and the data is mapped according to the encoded substrate. This configuration allows for the production of a 3-dimentional distribution profile of the multiple metal tags in the tissue sample.
    Type: Application
    Filed: October 22, 2013
    Publication date: May 1, 2014
    Applicant: DVS SCIENCES INC.
    Inventor: SCOTT TANNER
  • Publication number: 20130203627
    Abstract: A rapid diagnostic system that delivers a panel of serologic assay results using a small amount of blood, serum, or plasma is described. The system includes a disposable cartridge, including an integral lens portion coupled to a planar waveguide, and a reader instrument, based on planar waveguide imaging technology. The cartridge incorporates a microarray of recombinant antigens and antibody controls in a fluidic channel, providing multiple parallel fluorescence assay results for a single sample.
    Type: Application
    Filed: March 15, 2013
    Publication date: August 8, 2013
    Applicant: MBIO DIAGNOSTICS, INC.
    Inventor: MBIO DIAGNOSTICS, INC.
  • Publication number: 20130190211
    Abstract: A method of fabricating a microwell in an array structure is disclosed herein. The array structure can include a plurality of field effect transistors (FETs), where each FET has a gate structure. The method can include disposing a titanium nitride (TiN) layer on at least one conductive layer coupled to the gate structure of at least one FET. A insulation layer can also be disposed on the array structure, where the insulation layer lies above the TiN layer. Further, an opening above the gate structure of the at least one FET can be etched to remove the insulation layer above the gate structure and to expose the TiN layer. A microwell with at least one sidewall formed from the insulation layer and with a bottom surface formed from the TiN layer is a result of the etching process.
    Type: Application
    Filed: January 19, 2012
    Publication date: July 25, 2013
    Applicant: LIFE TECHNOLOGIES CORPORATION
    Inventors: James Bustillo, Todd Rearick, Wolfgang Hinz, Keith Fife
  • Publication number: 20130090264
    Abstract: An object of the invention is to provide a metal nanoparticle array structure in which metal nanoparticle arrays are firmly bonded to the substrate thereof via chemical bonding or the like and in which the coverage with the metal nanoparticle arrays is high. The problem can be solved by using a metal nanoparticle array structure 10 that comprises a substrate 1, a immobilizing layer 2 formed on one surface 1a of the substrate 1, and metal nanoparticle arrays 3 formed on one surface 2a of the immobilizing layer 2, wherein the metal nanoparticle arrays 3 are so arrayed that multiple metal nanoparticles 4 can be at regular intervals and the metal nanoparticles 4 are bonded to each other via the modifying part 5 arranged on a surface thereof while the metal nanoparticles 4 are immobilized on one surface 2a of the immobilizing layer 2 via chemical bonds.
    Type: Application
    Filed: March 3, 2011
    Publication date: April 11, 2013
    Applicant: NATIONAL INSTITUTE FOR MATERIALS SCIENCE
    Inventors: Katsuhiro Isozaki, Kazushi Miki, Takao Ochiai, Tomoya Taguchi, Kohichi Nittoh
  • Publication number: 20130040856
    Abstract: The disclosure relates to a method of forming a pattern having pattern elements with a plurality of sizes on a substrate surface with a tilted pen array that includes choosing a tilt geometry for a pen array with respect to a substrate, inducing the tilt geometry between the pen array and the substrate surface, and forming a pattern having pattern elements on the substrate surface with the titled pen array, whereby the size of the formed pattern elements varies across the substrate surface along the tilted axis or axes. For example, the tilt geometry is in reference to the substrate surface and comprises a first angle with respect to a first axis of the substrate and a second angle with respect to a second axis of the substrate, the second axis being perpendicular to the first axis, and at least one of the first and second angles being non-zero.
    Type: Application
    Filed: December 2, 2010
    Publication date: February 14, 2013
    Applicant: NORTHEWESTERN UNIVERSITY
    Inventors: Chad A. Mirkin, Adam B. Braunschweig, Jinan Chai, Dan J. Eichelsdoerfer, Louise R. Giam, Xing Liao, Lu Shin Wong
  • Publication number: 20130040862
    Abstract: A multi-pillar structure for molecular analysis is provided. The structure comprises at least two nanopoles, each nanopole attached at one end to a substrate and freely movable along its length. The opposite ends of the at least two nanopoles are each capable of movement toward each other to trap at least one analyte molecule at their opposite ends. Each nanopole is coated with a metal coating. An array of such multi-pillar structures is also provided. A method for preparing the multi-pillar structure is further provided.
    Type: Application
    Filed: April 20, 2010
    Publication date: February 14, 2013
    Inventors: Zhiyong Li, Min Hu, Fung Suong Ou, Wei Wu, R. Stanley Williams
  • Patent number: 8372949
    Abstract: The present invention includes methods for selective binding of inorganic materials and the compositions that made up of the selecting agent and the target materials. One form of the present invention is a method for selecting crystal-binding peptides with binding specificity including the steps of contacting one or more amino acid oligomers with one or more single-crystals of a semiconductor material so that the oligomers may bind to the crystal and eluting the bound amino acid oligomers from the single-crystals.
    Type: Grant
    Filed: July 24, 2007
    Date of Patent: February 12, 2013
    Assignee: The Board of Regents, The University of Texas System
    Inventor: Angela M. Belcher
  • Publication number: 20120238471
    Abstract: Systems and methods biochemically sense a concentration of a ligand using a sensor having a substrate having a metallic nanoparticle array formed onto a surface of the substrate. A light source is incident on the surface. A matrix is deposited over the nanoparticle array and contains a protein adapted to binding the ligand. A detector detects s-polarized and p-polarized light from the reflective surface. Spacing of nanoparticles in the array and wavelength of light are selected such that plasmon resonance occurs with an isotropic point such that ?s and ?p polarizations of the incident light result in substantially identical surface Plasmon resonance, wherein binding of the ligand to the protein shifts the resonance such that differences between the ?S and ?P polarizations give in a signal indicative of presence of the ligand.
    Type: Application
    Filed: March 16, 2012
    Publication date: September 20, 2012
    Inventor: Anatoliy Pinchuk
  • Publication number: 20120184451
    Abstract: Natural and/or synthetic antibodies for specific proteins are adhered to nanoparticles. The nanoparticles are adhered to a substrate and the substrate is exposed to a sample that may contain the specific proteins. The substrates are then tested with surface enhanced Raman scattering techniques and/or localized surface plasmon resonance techniques to quantify the amount of the specific protein in the sample.
    Type: Application
    Filed: December 2, 2011
    Publication date: July 19, 2012
    Applicant: WASHINGTON UNIVERSITY
    Inventors: Srikanth Singamaneni, Evan Kharasch, Jeremiah Morrissey, Chang Hee Lee
  • Publication number: 20120108465
    Abstract: A sensor array is provided including a plurality of fibers being woven to form 3-D periodic fiber structures. A selective number of the fibers include gaseous sensing materials to detect selective gases. A plurality of spacing elements provides adequate spacing between successively arranged nano-fibers. The nano-fibers and spacing elements are arranged to form a 3-D scaffolding structure for detecting specific or combinations of gaseous analytes.
    Type: Application
    Filed: September 28, 2009
    Publication date: May 3, 2012
    Inventors: Eric B. Duoss, Jennifer A. Lewis, Avner Rothschild, Kathy Sahner, Harry L. Tuller
  • Publication number: 20120077715
    Abstract: A carbon nanotube array is provided. The carbon nanotube array includes at least two isotope-doped carbon nanotube sub-arrays. Each isotope-doped carbon nanotube sub-array includes a plurality of carbon nanotubes. The carbon nanotubes in different isotope-doped carbon nanotube sub-array are composed of different kinds of carbon isotopes. The present disclosure also provides a method for making the carbon nanotube arrays.
    Type: Application
    Filed: March 25, 2011
    Publication date: March 29, 2012
    Applicants: HON HAI PRECISION INDUSTRY CO., LTD., TSINGHUA UNIVERSITY
    Inventors: LIANG LIU, KAI-LI JIANG, SHOU-SHAN FAN
  • Publication number: 20110230373
    Abstract: The present disclosure relates to a carbon nanotube array structure and a method for making the same. The carbon nanotube array structure includes a bendable flexible substrate and a carbon nanotube array. The flexible substrate has at least one surface. The carbon nanotube array is grown on at least one surface of the flexible substrate. In the method for making the carbon nanotube array structure, a reacting chamber, and a bendable flexible substrate with at least one surface are provided. The flexible substrate is disposed in the reacting chamber and heated to a certain temperature. A carbon source gas is supplied into the reacting chamber, thereby forming a carbon nanotube array on the catalyst layer.
    Type: Application
    Filed: October 29, 2010
    Publication date: September 22, 2011
    Applicant: BEIJING FUNATE INNOVATION TECHNOLOGY CO., LTD.
    Inventor: LIANG LIU
  • Publication number: 20110160095
    Abstract: A carbon nanotube precursor includes a strip-shaped carbon nanotube array comprising a plurality of carbon nanotubes. The strip-shaped carbon nanotube array is defined by dividing a carbon nanotube array with a separating line. A length of the strip-shaped carbon nanotube array is greater than a largest width of the carbon nanotube array.
    Type: Application
    Filed: June 29, 2010
    Publication date: June 30, 2011
    Applicants: TSINGHUA UNIVERSITY, HON HAI PRECISION INDUSTRY CO., LTD.
    Inventors: KAI-LI JIANG, LIANG LIU, SHOU-SHAN FAN
  • Publication number: 20110136691
    Abstract: Provided are a gold-silver alloy nanoparticle chip, a method of fabricating the same and a method of detecting microorganisms using the same. The gold-silver alloy nanoparticle chip includes a hydrophilized glass substrate, a self-assembled monolayer formed on the glass substrate, and gold-silver alloy nanoparticles fixed on the self-assembled monolayer. The gold-silver alloy nanoparticle chip having such a structure enables microorganisms in a water purifier and tap water to be readily detected and enables detection efficiency to be enhanced.
    Type: Application
    Filed: September 9, 2010
    Publication date: June 9, 2011
    Applicant: Electronics and Telecommunications Research Institute
    Inventors: Wan Joong KIM, Bong Kyu Kim, Gun Yong Sung, Chul Huh, Hyun Sung Ko, Jong Cheol Hong, Kyung Hyun Kim, Chil Seong Ah
  • Publication number: 20110118141
    Abstract: A disease specific panel having at least one primary test for different analytes that are relevant for either early detection of a primary disease or management of patients already diagnosed with said primary disease. The panel also includes at least one secondary test which is relevant for detection of a co-morbid condition or complications of the primary disease. Generally, the primary and secondary tests are disposed on a support surface. The disease specific panel is different from the prior art creening tests in that there are no tests included in the panel whose results are not relevant or do not relate to either primary disease or a co-morbid condition or complications of the primary disease. The disease specific panel may also include systems and methods utilizing algorithms for creating and outputting diagnostic aids, as well as warnings about the presence of possible sample interferants, especially those commonly associated with the subject disease of the panel.
    Type: Application
    Filed: June 24, 2009
    Publication date: May 19, 2011
    Applicant: Siemens Healthcare Diagnostics Inc.
    Inventor: Michael J. Pugia
  • Publication number: 20110053794
    Abstract: Provided according to embodiments of the invention are nanostructured surfaces that include a substrate; and an array of metallic nanopillar islands on the substrate, wherein each metallic nanopillar island includes a metal base layer on the substrate and a plurality of metallic nanopillars on the metal base layer, and wherein portions of the substrate between adjacent metallic nanopillar islands are free of the metal base layer. Also provided according to some embodiments of the invention are nanostructured surfaces that include a non-conductive substrate; and at least one nanoelectrode defined within the non-conductive substrate, wherein the at least one nanoelectrode is sized and/or shaped to immobilize an analyte or a probe molecule. Also provided are apparatuses and methods for SERS and detection of analytes or biological binding by EDL capacitance.
    Type: Application
    Filed: August 26, 2010
    Publication date: March 3, 2011
    Inventor: Guigen Zhang
  • Publication number: 20100324656
    Abstract: A method for manufacturing a carbon composite is provided. The method includes providing a carbon-containing resin material to which an appropriate concentration of catalyst particles may be added. Thereafter, the catalyzed resin may be subject to a high temperature range, at which point carbon in the resin to begins to couple to the catalyst particles. Continual exposure to high temperature leads to additional attachment of carbon to existing carbon on the particles. Subsequently growth, within the resin material, of an array of carbon nanotubes occurs, as well as the formation of the composite material.
    Type: Application
    Filed: July 22, 2010
    Publication date: December 23, 2010
    Inventors: David S. Lashmore, Joseph J. Brown
  • Publication number: 20100311605
    Abstract: A sensing platform includes: a plurality of metal nanoparticles; a plurality of aggregate inducers each comprising first and second functional groups different from each other, and the first functional group of the aggregate inducers being in contact with the metal nanoparticles; and a plurality of recognition molecules for binding the metal nanoparticles and for interacting with a target to recognize the target, wherein the second functional group of the aggregate inducers is free from being in contact with the metal nanoparticles, and is used to induce the metal nanoparticles to aggregate after the recognition molecules interact with the target.
    Type: Application
    Filed: September 25, 2009
    Publication date: December 9, 2010
    Applicant: NATIONAL CHIAO TUNG UNIVERSITY
    Inventors: Chih-Sheng Lin, Yao-Chen Chuang, Sz-Hao Chen
  • Publication number: 20100311615
    Abstract: The invention is directed to a method for producing titanium dioxide nanotubes, the method comprising anodizing titanium metal in contact with an electrolytic medium containing an ionic liquid. The invention is also directed to the resulting titanium dioxide nanotubes, as well as devices incorporating the nanotubes, such as photovoltaic devices, hydrogen generation devices, and hydrogen detection devices.
    Type: Application
    Filed: June 9, 2009
    Publication date: December 9, 2010
    Applicant: UT-BATTELLE, LLC
    Inventors: Jun Qu, Huimin Luo, Sheng Dai
  • Publication number: 20100279887
    Abstract: A method of separating a target biological analyte from a mixture of substances in a fluid sample employs nonlinear magnetophoresis. Magnetic particles having the capacity to bind to the target analyte are contacted with the fluid sample so that the analyte is immobilized on the surface of at least some of the particles. The magnetic particles are provided adjacent an array of micromagnets patterned on a substrate so that the particles are attracted the micromagnets. The magnetic particles are then subjected to a traveling magnetic field operating at or above a frequency effective to sweep those particles not bound to analyte to an adjacent micromagnet. Those magnetic particles bound to analyte have a larger size or smaller magnetic moment that prevents them from being moved to adjacent micromagnets, thereby affording separation of the analyte.
    Type: Application
    Filed: June 14, 2008
    Publication date: November 4, 2010
    Inventors: Gil U. Lee, Benjamin Yellen, Randall Morgan Erb
  • Patent number: 7824648
    Abstract: A carbon nanotube array includes a plurality of carbon nanotubes and at least one line mark formed on the carbon nanotubes. The carbon nanotubes have a top end and a bottom end. The at least one line mark is formed on the carbon nanotubes. The at least one line mark transversely extends across the carbon nanotubes, and is located between the top end and the bottom end. The at least one line mark is spaced from the top and bottom ends.
    Type: Grant
    Filed: April 29, 2010
    Date of Patent: November 2, 2010
    Assignees: Tsinghua University, Hon Hai Precision Industry Co., Ltd.
    Inventors: Kai-Li Jiang, Kai Liu, Shou-Shan Fan
  • Patent number: 7803739
    Abstract: The present invention is directed to novel substrates for Hu-Asp. More particularly, the invention provides peptide substrates and fusion polypeptide substrates comprising a ?-secretase cleavage site. Methods and compositions for making and using the peptides are disclosed.
    Type: Grant
    Filed: March 16, 2004
    Date of Patent: September 28, 2010
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Riqiang Yan, Alfredo G. Tomasselli, Mark E. Gurney, Thomas L. Emmons, Michael Jerome Bienkowski, Robert L. Heinrikson
  • Patent number: 7767627
    Abstract: Methods and apparatus for the preparation and use of a substrate having an array of diverse materials in predefined regions thereon. A substrate having an array of diverse materials thereon is generally prepared by delivering components of materials to predefined regions on a substrate, and simultaneously reacting the components to form at least two materials or, alternatively, allowing the components to interact to form at least two different materials. Materials which can be prepared using the methods and apparatus of the present invention include, for example, covalent network solids, ionic solids and molecular solids. More particularly, materials which can be prepared using the methods and apparatus of the present invention include, for example, inorganic materials, intermetallic materials, metal alloys, ceramic materials, organic materials, organometallic materials, nonbiological organic polymers, composite materials (e.g., inorganic composites, organic composites, or combinations thereof), etc.
    Type: Grant
    Filed: April 22, 1997
    Date of Patent: August 3, 2010
    Assignees: Symyx Solutions, Inc., The Regents of the University of California
    Inventors: Isy Goldwasser, Debra A. Ross, Peter G. Schultz, Xiao-Dong Xiang, Gabriel Briceño, Xian-Dong Sun, Kai-An Wang
  • Patent number: 7749477
    Abstract: A carbon nanotube array includes a plurality of carbon nanotubes. Each of the carbon nanotubes has a plurality of line marks formed on each of the carbon nanotubes. The line marks transversely extend across the carbon nanotubes. The line marks of each of the carbon nanotubes are spaced apart from each other.
    Type: Grant
    Filed: December 19, 2008
    Date of Patent: July 6, 2010
    Assignees: Tsinghua University, Hon Hai Precision Industry Co., Ltd.
    Inventors: Kai-Li Jiang, Kai Liu, Shou-Shan Fan
  • Patent number: 7666818
    Abstract: A combinatorial library includes a gelcast substrate defining a plurality of cavities in at least one surface thereof; and a plurality of gelcast test materials in the cavities, at least two of the test materials differing from the substrate in at least one compositional characteristic, the two test materials differing from each other in at least one compositional characteristic.
    Type: Grant
    Filed: March 13, 2006
    Date of Patent: February 23, 2010
    Assignee: UT-Battelle, LLC
    Inventors: Robert J. Lauf, Claudia A. Walls, Lynn A. Boatner
  • Patent number: 7651979
    Abstract: The present invention relates to novel coordination complexes, methods for synthesizing and identifying coordination complexes, using combinatorial techniques, and assaying their activity.
    Type: Grant
    Filed: August 27, 2004
    Date of Patent: January 26, 2010
    Assignee: Massachusetts Institute of Technology
    Inventors: Stephen J. Lippard, Christopher J. Ziegler
  • Publication number: 20090278114
    Abstract: The diameter of carbon nanotubes grown by chemical vapor deposition is controlled independent of the catalyst size by controlling the residence time of reactive gases in the reactor.
    Type: Application
    Filed: June 12, 2009
    Publication date: November 12, 2009
    Applicant: International Business Machines Corporation
    Inventors: Alfred Grill, Deborah Neumayer, Dinkar Singh
  • Publication number: 20090253590
    Abstract: The present invention attempts to establish a method for surface-fixing single-walled carbon nanotubes having a desired chirality highly selected from among the single-walled carbon nanotubes having various chiralities, and utilizes the method to provide an array of the carbon nanotubes for electronic devices. The present invention attempts also to provide a carbon nanotube composition including carbon nanotubes having a single chiral vector (n, m) at a purity of more than 50% based on the unit of number wherein n and m are integers, and a method for manufacturing the same.
    Type: Application
    Filed: May 12, 2006
    Publication date: October 8, 2009
    Applicant: National University Corporation Hokkaido University
    Inventors: Kei Murakoshi, Norihiko Takeda
  • Publication number: 20090221443
    Abstract: The invention relates to processes and devices for the controlled fabrication of nanostructures from starting components that have high fidelity recognition properties and multiple binding groups. In one embodiment, the invention relates to the formation of nanostructures using controlled sequential addition of nanocomponents at regular intervials via sequential formation of binding pairs or other chemical binding reactions.
    Type: Application
    Filed: May 11, 2006
    Publication date: September 3, 2009
    Applicant: The Regents of the University of California
    Inventors: Michael Heller, Benjamin Sullivan, Dietrich Dehlinger
  • Publication number: 20090215651
    Abstract: A carbon nanotube array includes a plurality of carbon nanotubes aligned in a uniform direction. Each carbon nanotube has at least one line mark formed thereon.
    Type: Application
    Filed: December 19, 2008
    Publication date: August 27, 2009
    Applicants: Tsinghua University, HON HAI Precision Industry Co., LTD.
    Inventors: Kai-Li Jiang, Kai Liu, Shou-Shan Fan
  • Publication number: 20090170725
    Abstract: The methods, apparatus and systems disclosed herein concern ordered arrays of carbon nanotubes. In particular embodiments of the invention, the nanotube arrays are formed by a method comprising attaching catalyst nanoparticles 140, 230 to polymer 120, 210 molecules, attaching the polymer 120, 210 molecules to a substrate, removing the polymer 120, 210 molecules and producing carbon nanotubes on the catalyst nanoparticles 140, 230. The polymer 120, 210 molecules can be attached to the substrate in ordered patterns, using self-assembly or molecular alignment techniques. The nanotube arrays can be attached to selected areas 110, 310 of the substrate. Within the selected areas 110, 310, the nanotubes are distributed non-randomly. Other embodiments disclosed herein concern apparatus that include ordered arrays of nanotubes attached to a substrate and systems that include ordered arrays of carbon nanotubes attached to a substrate, produced by the claimed methods.
    Type: Application
    Filed: January 31, 2006
    Publication date: July 2, 2009
    Inventors: Mineo Yamakawa, Yuegang Zhang, Xing Su, Lei Sun, Andrew A. Berlin, Narayanan Sundararajan
  • Publication number: 20090131274
    Abstract: This invention relates generally to biosensor technology, and pertains more particularly to novel multifunctional biosensors based on ordered arrays of metallic, semiconductors and magnetic nano-islands for medical, biological, biochemical, chemical and environmental applications.
    Type: Application
    Filed: June 6, 2006
    Publication date: May 21, 2009
    Applicant: GILUPI GMBH
    Inventors: Ulrich Pison, Michael Giersig, Alex Schaefer
  • Publication number: 20090124518
    Abstract: A method for assaying phenotypic similarity or dissimilarity between organisms is disclosed in which a composite sample of admixed first and second samples is provided. The first, standard sample contains average concentrations of compounds of molecular mass less than about 1000 AMU present in the organism species. The second, assay sample contains compounds of having a similar molecular mass present in the organism whose phenotype is to be assayed. The constituents of both samples are (i) in a liquid medium and (ii) each compound of a sample has the same, first and second respective amounts of first and second stable isotopes of a first atom. The composite sample is mass spectroscopically analyzed for analytes, with the ratio of first to second isotope being determined for each analyte, along with a composite sample median ratio. The ratios for each analyte are compared to the median, with outlying ratios indicating dissimilarity.
    Type: Application
    Filed: October 2, 2008
    Publication date: May 14, 2009
    Inventor: Christopher William Ward Beecher
  • Publication number: 20090124509
    Abstract: The invention relates to an arrangement of proteins containing at least one cDNA-expression library and to the use thereof as a protein-biochip, in particular for validating binding agents and protein binding agents and to a method for determining in a simultaneous manner quantitative variables.
    Type: Application
    Filed: November 24, 2005
    Publication date: May 14, 2009
    Applicant: Protagen AG
    Inventors: Petra Weingarten, Angelika Luking, Verena Trappe
  • Patent number: 7462490
    Abstract: A combinatorial lubricating oil composition library is provided including at least a plurality of different lubricating oil compositions comprising (a) a major amount of a base oil of lubricating viscosity and (b) at least one lubricating oil additive. Methods for preparing same are also provided.
    Type: Grant
    Filed: October 31, 2003
    Date of Patent: December 9, 2008
    Assignee: Chevron Oronite Company LLC
    Inventors: Robert H. Wollenberg, Thomas J. Balk