Abstract: Provided herein are methods and compositions for chemical mechanical polishing (CMP) of metals. The present methods and compositions involve the use of a corrosion inhibitor having the general formula CmH2m+1—(OCH2CH2)n-L-R in the CMP slurry composition, where m is an integer between 6 and 11, inclusive of end points, and n is an integer greater than or equal to 6, L is a bond, —O—, —S—, —R1—, —S—R1—, or —O—R1—, where R1 is a C1-4 alkylene; and R is an anionic group. The present methods and compositions can be used to achieve a high metal removal rate, while effectively inhibiting metal corrosion during CMP, and are particularly useful for CMP of cobalt (Co).

Abstract: Methods of making a (e.g. dilute) cleaning solution from a hydrogel cleaning concentrate, packages of hydrogel cleaning concentrate, and methods of making a hydrogel cleaning concentrate are described.

Abstract: The present invention provides a lens care kit for disinfecting and cleaning contact lenses. The lens care kit of the invention allows customers to visually identify when their lenses are disinfected, clean, and ready to wear. The invention is relied on color change to indicate the readiness of disinfection and cleaning of contact lenses.

Abstract: A contact lens-treating solution contains polyelectrolyte complex particulates and an aqueous solution for dispersing the polyelectrolyte complex particulates. Each of the polyelectrolyte complex particulates is formed of a cationic polymer and an anionic polymer. The aqueous solution contains water and an additive including a surfactant, an antibacterial agent, a cleaning agent, a thickening agent, a chelating agent, and combinations thereof for cleaning or maintaining the contact lens. A method for treating a contact lens using a contact lens-treating solution containing water and polyelectrolyte complex particulates is also disclosed.

Abstract: A method of making antimicrobial quaternary ammonium polymers, comprising: a) mixing 1,4-bis-dimethylamino-2-butene, water, a first portion of triethanolamine and a first portion of acid; b) adding a 1,4-dihalo-2-butene and heating the reaction mixture; c) adding a second portion of triethanolamine and a second portion of acid, and d) isolating a quaternary ammonium polymer having a molecular weight of at least 26 k.

Abstract: The present embodiments relate to a novel method of making quaternary ammonium polymers comprising the steps of: a) mixing 1,4-bis-dimethylamino-2-butene, triethanolamine, water and an acid; and b) introducing a 1,4-dihalo-2-butene to the mixture so as to initiate a reaction resulting in the quaternary ammonium polymer.

Abstract: The use of NIPAM polymers to prevent or reduce the formation of protein deposits on the surfaces of medical devices is described. The invention is particularly directed to reduction of the adsorption of proteins on surfaces of contact lenses and other medical prosthetics.

Abstract: The present invention relates to contact lens care product comprising dexpanthenol. The invention similarly relates to the usage of a contact lens care compositions of this kind for cleaning and optionally disinfecting contact lenses.

Abstract: A method and composition for disinfecting a contact lens is disclosed. The method includes treating a lens with an aqueous solution having reduced toxicity to the eye which contains an effective amount of a monoperphthalic acid compound in a concentration of less than about 0.5% by weight of the solution. The lens disinfecting solution is capable of disinfecting contact lenses without irritating the eye due to reduced toxicity of the composition.

Abstract: An in-eye method for cleaning contact lenses comprises use of a cleaner using water-containing beads. The water-containing beads are prepared such that the bead size is smaller than the punctual opening. They are easily flushed from the ocular environment by normal tear flow. The cleaner may also be used to clean contact lenses, with the cleaner applied directly to the lens and digitally rubbed to remove accumulated debris on the lens.

Abstract: A method of disinfecting a contact lens is provided, including the steps of preparing a disinfecting liquid which contains water-dispersible fine particles of a titanium oxide dispersed in an aqueous medium, immersing the contact lens in the disinfecting liquid; and irradiating the disinfecting liquid in which the contact lens is immersed, with a light.

Abstract: A method and composition for disinfecting a contact lens is disclosed. The method includes treating a lens with an aqueous solution having reduced toxicity to the eye which contains an effective amount of a monoperphthalic acid compound in a concentration of less than about 0.5% by weight of the solution. The lens disinfecting solution is capable of disinfecting contact lenses without irritating the eye due to reduced toxicity of the composition.

Abstract: The present invention relates to a solid enzyme cleaning composition in which the enzyme is stable in the presence of mixtures of carbonate and bicarbonate at alkaline pH, and methods employing this composition. The enzyme cleaning composition preferably employs weight ratios of carbonate and bicarbonate to stabilize one or more enzymes in a solid, a concentrate, and/or a use composition, and at temperatures higher than ambient.

Abstract: A method and composition for disinfecting a contact lens is disclosed. The method includes treating a lens with an aqueous solution having reduced toxicity to the eye which contains an effective amount of a monoperphthalic acid compound in a concentration of less than about 0.5% by weight of the solution. The lens disinfecting solution is capable of disinfecting contact lenses without irritating the eye due to reduced toxicity of the composition.

Abstract: The invention provides a method for inhibiting the binding of a biguanide antimicrobial in aqueous solution to a hydrogel in contact with said solution comprising providing in said solution an amount of cyclodextrin sufficient to inhibit sorption of the biguanide antimicrobial to a hydrogel.

Abstract: Multi-purpose solutions for contact lens care provide substantial lens wearer/user comfort and/or acceptability. Such solutions include an aqueous liquid medium; an antimicrobial component, preferably a biguanide polymer present in an amount of less than about 5 ppm; a surfactant component, preferably a poly(oxyethylene)-poly(oxypropylene) block copolymer surfactant, in an effective amount; a phosphate buffer component in an effective amount; a viscosity inducing component, preferably selected from cellulosic derivatives, in an effective amount; and a tonicity component in an effective amount. Such solutions have substantial performance, comfort and-acceptability benefits, which, ultimately, lead to ocular health advantages and avoidance of problems caused by contact lens wear.

Abstract: The present invention provides an agent for contact lenses, which contains an oxo-acid compound and/or a polyacid compound. The agent for contact lenses of the present invention can remove protein as, for example, a protein remover, irrespective of the kind of contact lens and without using a special cleaning device. In addition, washing with water after protein removal is not necessary.

Abstract: The invention is directed to compositions and methods used as in-the-eye and/or out-of-eye inhibitors of proteinaceous deposits on hydrophilic contact lenses. Compositions of the present invention comprise moderately charged polyquaternium polymers that selectively bind to hydrophilic contact lenses to block the binding of proteinaceous materials. Compositions of the present invention may be used in multipurpose cleaning solutions for contact lenses and can eliminate the need for special enzyme cleaners and the like for removing proteinaceous materials.

Abstract: Multi-purpose solutions for contact lens care provide substantial lens wearer/user comfort and/or acceptability. Such solutions include an aqueous liquid medium; an antimicrobial component, preferably a biguanide polymer present in an amount of less than about 5 ppm; a surfactant component, preferably a poly(oxyethylene)-poly(oxypropylene) block copolymer surfactant, in an effective amount; a phosphate buffer component in an effective amount; a viscosity inducing component, preferably selected from cellulosic derivatives, in an effective amount; and a tonicity component in an effective amount. Such solutions have substantial performance, comfort and acceptability benefits, which, ultimately, lead to ocular health advantages and avoidance of problems caused by contact lens wear.

Abstract: A compacted granulate and a method for making the same, comprises 60-99 wt.-% of a water-insoluble, water-swellable cellulose and optionally at least one water-swellable polysaccharide derivative, 1-40 wt.-% of at least one polymeric binder of a polymer or a copolymer of (meth)acrylic acid and/or salts thereof, and at least one liquid surfactant, in which the granulate has a water content of from 2 to 8 wt.-%.

Abstract: The present invention is based on the unexpected finding that the combination of a carboxylate containing anionic polymer, of molecular weight greater than about 1000 daltons, with cleaning agents, provides improved contact lens cleaning preparations. The present invention includes contacting a soiled contact lens with an aqueous solution comprising an anionically charged polymer and a surfactant or surfactant combination selected from the classes of nonionic surfactants, anionic surfactants, and amphoteric surfactants.

Abstract: Contact-lens disinfectant containing(a) magnesium monoperphthalate and(b) sodium cumenesulphonate,(c) sodium alkylbenzenesulphonate,(d) isotridecanol ethoxylate and(e) methylhydroxyethylcellulose,and packaging and a process for the preparation thereof.

Abstract: The present invention is directed to an ophthalmically safe disinfecting solution for contact lenses comprising the combination of a polymeric biguanide and a polyquaternium polymer of a substituted or unsubstituted vinylimidazole or its vinylimidazoliuum salt, which copolymer has a weight average molecular weight of 5,000 to 5,000,000. The invention is also directed to an improved method of disinfecting a contact lens.

Abstract: Multi-purpose solutions for contact lens care provide substantial lens wearer/user comfort and/or acceptability. Such solutions include an aqueous liquid medium; an antimicrobial component, preferably a biguanide polymer present in an amount of less than about 5 ppm; a surfactant component, preferably a poly(oxyethylene)-poly(oxypropylene) block copolymer surfactant, in an effective amount; a phosphate buffer component in an effective amount; a viscosity inducing component, preferably selected from cellulosic derivatives, in an effective amount; and a tonicity component in an effective amount. Such solutions have substantial performance, comfort and acceptability benefits, which, ultimately, lead to ocular health advantages and avoidance of problems caused by contact lens wear.

Abstract: An aqueous composition for cleaning contact lenses comprises an aliphatic monohydric alcohol, a surface active agent having cleaning action for contact lens deposits, and an abrasive agent.

Abstract: The invention discloses PEG-modified proteases, compositions containing these modified enzymes, and methods for using them to clean contact lenses. The methods of the present invention are also directed to the simultaneous cleaning and disinfecting of contact lenses, when compositions of the present invention are combined with a suitable disinfectant.

Abstract: Compositions and methods useful for disinfecting a contact lens are disclosed. The present methods comprise contacting a contact lens with a liquid medium containing an effective amount of an oxidative disinfectant component at conditions to effectively disinfect the contact lens. The contacting occurs in the presence of a color indicator component which is soluble in the liquid medium and is adapted to provide a color indication of the presence of the oxidative disinfectant component in the liquid medium. The color indicator component comprises an effective amount of a transition metal component which is redox active, has an oxidized state of a first color and a reduced state of a different second color and a polyanionic component in an amount effective to inhibit the staining of the contact lens by the transition metal component.

Abstract: A method of simultaneously cleaning and disinfecting a contact lens is disclosed, which method comprises the steps of: (a) preparing a cleaning solution for the contact lens comprising an effective amount of a proteolytic enzyme, 15-60 w/v % (percent by weight/volume) of propylene glycol, 10-60 w/v % of glycerine, and water, a total content of the propylene glycol and glycerine being in a range of 30-80 w/v %; (b) diluting the cleaning solution with a disinfecting or storing liquid for the contact lens which contains an ionic antimicrobial agent, so as to provide a dilution; and (c) immersing the contact lens in the dilution.

Abstract: It is an object of the present invention to provide a cleaning and disinfecting solution for a contact lens to be cleaned and disinfected simultaneously in a simplified manner with high efficiency. It is also an object of the present invention to provide a method of cleaning and disinfecting the contact lens wherein the cleaning and disinfection of the contact lens can be effected simultaneously in a short period of time by using the above-indicated cleaning and disinfecting solution. The above objects may be obtained according to one aspect of the present invention which provided a cleaning and disinfecting solution for a contact lens comprising an effective amount of proteolytic enzyme, 60-80% w/v % of propylene glycol, 10-35% w/v % of glycerine, and water, a total content of propylene glycol and glycerine being in the range of 70% to 95 w/v %.

Abstract: Compositions containing a stable, liquid, ophthalmically acceptable enzyme and methods involving the combined use of these compositions with a polymeric antimicrobial agent are disclosed for the simultaneous cleaning and disinfecting of contact lens. Methods for a daily use regimen are also disclosed.

Abstract: Compositions and methods for caring for a contact lens include an inositol phosphate component in an amount effective to at least facilitate the beneficial treatment of the lens.

Abstract: Compositions and methods useful for disinfecting a contact lens are disclosed. The present methods comprise contacting a contact lens with a liquid medium containing an effective amount of an oxidative disinfectant component at conditions to effectively disinfect the contact lens. The contacting occurs in the presence of a color indicator component which is soluble in the liquid medium and is adapted to provide a color indication of the presence of the oxidative disinfectant component in the liquid medium. The color indicator component comprises an effective amount of a transition metal component which is redox active, has an oxidized state of a first color and a reduced state of a different second color and a polyanionic component in an amount effective to inhibit the staining of the contact lens by the transition metal component.

Abstract: Compositions and methods are provided for cleaning and wetting of contact lenses, especially rigid, gas-permeable contact lenses. The compositions comprise low molecular weight polyalkylene oxide modified siloxanes, which are particularly effective in removing lipids from the surface of contact lenses.

Abstract: Compositions and methods for treating a contact lens are disclosed. In one embodiment, the composition comprises an ophthalmically acceptable liquid aqueous medium and a plurality of particles which possess a hardness gradient. The hardness gradient of the particles is due to the particles having a relatively inelastic, water-impermeable core and a soft, water-permeable outer layer surrounding the core. The particles afford both high specific pressure on a contact lens surface and textural softness, which diminishes surface abrasion.

Abstract: Granular detergent compositions of density >55 g/liter are provided comprising a plurality of particulate components, wherein one or more surfactant-containing particulate components comprise a surfactant system consisting essentially of one or more primary anionic or nonionic surfactants in intimate admixture with a water-soluble C.sub.11 -C.sub.18 alkyl ethoxysulfate salt containing an average of from one to seven ethoxy groups per mole, together with a builder system. The weight ratio of the primary anionic or nonionic surfactants or mixtures thereof to the alkyl ethoxysulfate salt is in the range from 19:1 to 2:1 provided that the level of the alkyl ethoxysulfate salt is from 0.25% to 10% by weight of the component. Improved rate of dissolution characteristics are observed for the composition and for the individual particulate components containing said surfactant system.

Abstract: A detergent composition is disclosed. The composition comprises polymer particles having an average particle size of 50-500 .mu.m in 5% by weight sodium chloride aqueous solution and a modulus of elasticity of 1.times.10.sup.3 -5.times.10.sup.5 dyne/cm.sup.2 in said sodium chloride aqueous solution. It exhibits a superior physical or mechanical washing performance, and gives remarkably reduced irritation and minimal damage to the object being washed. When a germicide is incorporated in addition to the polymer particles, its sterilization effect is greatly enhanced.