Abstract: A preservative-free contact lens treating solution includes (a) about 0.005 to about 2 wt. %, based on the total weight of the preservative-free contact lens treating solution, of hyaluronic acid or a salt thereof; (b) about 0.01 to about 1 wt. %, based on the total weight of the preservative-free contact lens treating solution, of erythritol; (c) one or more nonionic surfactants; (d) sodium chloride, potassium chloride or any combination thereof; and (e) one or more buffers.

Abstract: There is disclosed a formulation suitable for the reduction or prevention of contamination of articles by microorganisms. The formulation includes at least one block copolymer of ethylene oxide and propylene oxide, at least one polyacrylic acid salt, and at least one propoxylated ethylenediamine compound.

Abstract: The present invention relates to ophthalmic compositions and methods for the treatment of dry eye and other inflammatory ocular conditions. In particular, the present invention relates to a composition comprising an esterified anti-inflammatory lipid mediator, which is an ester of an anti-inflammatory lipid mediator that is a reaction product of the anti-inflammatory lipid mediator and a monohydric alcohol or an amide wherein the majority of the anti-inflammatory lipid mediator is present in an ester form. In this way, the compositions are substantially free of an acid form of the anti-inflammatory lipid mediators. Anti-inflammatory lipid mediators can be selected from the group consisting of polyunsaturated fatty acids (e.g.

Abstract: The present invention is a contact lens treatment solution containing the following copolymer A and copolymer B in a ratio of A/B=1000/1 to 2/1 (by weight). According to the present invention, there can be provided a contact lens treatment solution capable of removing dirt having adhered to contact lens surfaces and capable of imparting persisting hydrophilicity to contact lens surfaces, by simple immersion treatment. Copolymer A: a copolymer obtained by copolymerization of a monomer (a) represented by formula (1) and a monomer (b) represented by formula (2), in which the copolymerization ratio of the monomer (a) to the monomer (b), a/b=7/3 to 9/1 (by mol), and having a weight-average molecular weight of 400,000 to 700,000.

Abstract: Provided is a treating solution for soft contact lenses capable of imparting hydrophilicity and sustainability thereof to a soft contact lens surface. It has been found that a treating solution for soft contact lenses containing a copolymer that contains two kinds of monomers different from each other as constituent units at a specific ratio, and that has a specific weight-average molecular weight can impart excellent hydrophilicity and sustainability thereof.

Abstract: The present invention is a contact lens treatment solution containing the following copolymer A and copolymer B in a ratio of A/B=40/1 to 5/1 (by weight). According to the present invention, there can be provided a contact lens treatment solution capable of removing dirt having adhered to contact lens surfaces, capable of improving lubricity of contact lens surfaces and capable of imparting persisting hydrophilicity to contact lens surfaces, by simple immersion treatment. Copolymer A: a copolymer obtained by copolymerization of a monomer (a) represented by formula (1) and a monomer (b) represented by formula (2), in which the copolymerization ratio of the monomer (a) to the monomer (b), a/b=7/3 to 9/1 (by mol), and having a weight-average molecular weight of 400,000 to 800,000.

Abstract: A polymerizable composition, polymer capsules and a fabric softener composition are provided. The fabric softener composition includes polymer capsules in which cationic groups are introduced on the surfaces thereof, so that early release of a fragrance can be suppressed and aromas can be generated depending on rupture of a shell material of the polymer capsules by light friction at certain times. In addition, the polymer capsules have high adhesion to fibers and are not attached to fibers during washing to minimize the discharged fragrance, so that sufficient aromas can be provided even if a small amount of fragrance is used.

Abstract: A sporicidal composition has a moderately low pH and includes a glycosidase and the dissocia-tion product of at least one inorganic oxidizing agent. High effective solute concentrations can enhance the efficacy of the composition. The composition can be applied to a surface and allowed to absorb into an endospore, ultimately killing at least some of those bacteria in mature endospore form. Surfaces to be treated include inanimate (hard) surfaces via cleaning and medical devices such as endoscopes, typically via immersion.

Abstract: The invention provides aqueous ophthalmic solutions of phentolamine or pharmaceutically acceptable salts thereof, medical kits, and methods for using such ophthalmic solutions to improve visual performance in a patient. Exemplary aqueous ophthalmic solutions include those containing phentolamine mesylate, mannitol, sodium acetate, and water.

Abstract: A cleaning composition including a primarily C12 quaternary functionalized alkyl polyglucoside selected from the group consisting of stearyldimoniumhydroxypropyl laurylglucosides chloride and lauryldimoniumhydroxypropyl cocoglucosides chloride, a water conditioning agent, an acid source, a solvent, and water. In one embodiment, the cleaning composition is substantially free of alkyl phenol ethoxylates. The cleaning composition is capable of removing soils including up to 20% proteins. The cleaning compositions include a biorenewable, environmentally friendly alternative to nonyl phenol ethoxylates and exhibit superior cleaning of food soils.

Abstract: The present invention relates to compositions providing improved preservative efficacy. The present invention further relates to polyquaternium compound containing compositions having improved the antifungal activity. In certain embodiments, the present invention relates to ophthalmic compositions comprising a polyquaternium compound, a polyol or combination of polyols, borate compound, and an antimicrobial mixture comprising electrolytes and nutrients.

Abstract: The invention is directed to a method of cleaning and disinfecting a contact lens. The method includes instructing a consumer to disinfect their contact lens comprising the following steps: remove a contact from an eye and position the lens in a lens assembly that includes a cap member; add a disinfection solution to the lens case such that the lens is submerged in the solution upon closure of the lens case with the cap member. The disinfection solution will comprise 0.5 wt. % to 6 wt. % hydrogen peroxide or a chemical precursor of hydrogen peroxide, and a P-metal modulating compound. The presence of the P-metal modulating compound in the disinfection solution decreases the neutralization rate of the hydrogen peroxide. The disinfection system exhibits a pseudo first-order, half-life of hydrogen peroxide from 12 minutes to 30 minutes over an initial sixty minutes of neutralization following exposure of the disinfection solution to a catalyst comprising a P-metal.

Abstract: A disinfecting solution for a nonionic soft contact lens, which solution contains polylysine as a disinfectant, and further contains: 0.1-1.0% by weight of a component (A) which is an acidic tonicity agent having at least one carboxyl group; 0.10-1.25% by weight of a component (B) which is a basic tonicity agent having an amino group; and 0.1-2.0% by weight of a component (C) which is at least one of a nonionic tonicity agent and an amphoteric tonicity agent, wherein each of the components (A) to (C) has a molecular weight of not larger than 200, and a ratio of a molar concentration of the component (A) to a molar concentration of the component (B) is not larger than 1.2. The disinfecting solution has a pH of 6.5-8.0, an osmotic pressure of 250-330 mOsm/kg and an electric conductivity of 130-750 mS/m.

Abstract: A cleaning composition including a primarily C12 quaternary functionalized alkyl polyglucoside selected from the group consisting of stearyldimoniumhydroxypropyl laurylglucosides chloride and lauryldimoniumhydroxypropyl cocoglucosides chloride, a water conditioning agent, an acid source, a solvent, and water. In one embodiment, the cleaning composition is substantially free of alkyl phenol ethoxylates. The cleaning composition is capable of removing soils including up to 20% proteins. The cleaning compositions include a biorenewable, environmentally friendly alternative to nonyl phenol ethoxylates and exhibit superior cleaning of food soils.

Abstract: An object of the invention is to provide an application method capable of facilitating the application of the soft contact lens without using any instrument, a liquid for contact lenses capable of being used for the application method, and a soft contact lens package. The present invention is a method for applying a soft contact lens, including a shrinkage step of shrinking a soft contact lens by contacting the soft contact lens with a liquid for contact lenses, the liquid for contact lenses being capable of shrinking the soft contact lens to a state of being more intensively shrunken than an equilibrium state thereof in a physiological saline; and an application step of applying the shrunken soft contact lens to the eye, in which after the application step, the size of the soft contact lens is restored.

Abstract: Methods and apparatus for separating mold sections, removing a lens product from the separated mold sections, and transferring the lens product to a processing tray are provided and include contacting assembled mold sections with a warm fluid to break fused portions between the mold sections, and using one or more wedge shaped elements to pry apart and separate the mold sections, one from the other. A vacuum head having multiple vacuum ports is employed for lifting the newly molded lens product from a mold section and for releasing the lens from the vacuum head into a processing tray. A cylinder of flowing air directed around the circumference of the lens is effective to maintain the lens in an unfolded position as the lens is being released into the processing tray. A tray set including multiple trays holding multiple lenses is provided and includes features for enabling visual and/or mechanical distinction of the trays and lenses held thereby.

Abstract: The present invention provides a base composition that allows for the formulation of non-irritating cosmetic and/or dermatological compositions. The base composition includes one or more of electrolyte, buffer, mild preservative, lubricant, or any combinations thereof. It is preferred that one or more of the above components are eye-safe and/or eye-compatible. The present invention also provides photoprotective cosmetic and/or dermatological compositions that include the base composition and one or more sunscreen active components and are non-irritating to mammalian eyes.

Abstract: Provided are a contact lens care preparation capable of imparting durable surface lubricity and amebic adhesion inhibitory effect to a contact lens surface through a simple treatment, and a contact lens packaging solution utilizing the same. The contact lens care preparation is composed of a solution containing 0.01 to 2 weight/volume % of a polymer having particular monomer units with a phosphorylcholine-like group, particular (meth)acrylamide derivative units, and particular monomer units with a hydrophobic group at a particular ratio, and a weight average molecular weight of 5,000 to 2,000,000, and is useful as a contact lens packaging solution.

Abstract: The invention provides a contact lens cleaning composition comprising at least two nonionic surfactants and optionally including a non-Newtonian viscosity enhancing excipient.

Abstract: The invention provides a contact lens cleaning composition comprising at least two nonionic surfactants and optionally including a non-Newtonian viscosity enhancing excipient.

Abstract: This invention relates to an aqueous ophthalmic composition comprising (A) polyoxyethylene castor oil in which the number of moles of added ethylene oxide is 2 to 30, and (B) at least one member selected from the group consisting of castor oil and vitamin A. According to the aqueous ophthalmic composition of the present invention, the defoaming time can be reduced even when foam is generated by vibration or impact.

Abstract: A used contact lens is placed in a contact lens receptacle. An aqueous composition is added to the contact lens receptacle, the aqueous composition capable of changing from a first appearance to a second appearance in response to an interaction with the used contact lens after a predetermined period of time.

Abstract: The present invention relates to compositions and methods for eye and contact lens care. More particularly, the invention relates to ophthalmic compositions which contain at least one bioflavonoid component for ocular care, preserving ophthalmic solutions and/or disinfecting contact lenses.

Abstract: There are provided a stabilized polyphenol solution which is applicable as various contact lens solutions and has high lens compatibility and safety, and further also a method for stabilizing such a polyphenol solution. At least one inorganic salt-free buffer is contained in a concentration of 0.001-5% by weight in an aqueous solution containing at least one polyphenol, at least one polyol is further contained therein in a concentration of 0.01-5% by weight to prepare a solution so as to contain no inorganic salt, and the pH of the solution is adjusted to 7.3 or less.

Abstract: A synchronized water is disclosed, in which all single water molecules at the same time are arranged in an identical way to a stable homogeneous microstructure, wherein said synchronized water in a distilled condition and at atmospheric pressure has a) a density of from 0.997855 to 0.998836 g/ml at 22° C., b) a water temperature at the freezing point of from ?6.7° C. to ?8.2° C., c) a melting point of from 0.1° C. to 0.2° C., d) a surface tension of from 72.3 to 72.7 dyn/cm at 22 and e) a dielectric constant of from 82.4 to 82.6 F/m, as well as a method for preparation thereof and different uses thereof.

Abstract: An ophthalmic solution comprising a polyethoxylated glyceride in the range of 0.001 to about 10 percent by weight and a buffer agent. These solutions impart surprising comfort and wearability to contact lenses. At the same time the solutions provide good preservative capacity and do not increase protein deposit.

Abstract: Antimicrobial or preservative compositions with high user comfort and/or low ocular irritation. The compositions comprise a polyquaternary ammonium compound and an amidoamine having an alcohol group and exhibit synergistic antimicrobial activity. The compositions may be used as stand-alone antimicrobials/preservatives or may be incorporated into other ocular compositions such as those for ocular lens care or the treatment of ocular conditions.

Abstract: The present invention provides a lens care kit for disinfecting and cleaning contact lenses. The lens care kit of the invention allows customers to visually identify when their lenses are disinfected, clean, and ready to wear. The invention is relied on color change to indicate the readiness of disinfection and cleaning of contact lenses.

Abstract: The present invention provides an aqueous solution for sterilizing and storing ophthalmic devices, preferably a contact lens, made of a hydrogel material, preferably a poly(oxyalkylene)-containing hydrogel material. The solution comprises one or more organic buffer agents, such as a Good buffer or a bis-aminopolyols; an organic tonicity-adjusting agent with multiple hydroxyl groups in an amount sufficient to provide an osmolarity of from about 200 to about 450 mosm/l, wherein the aqueous solution has a pH of from about 5.5 to about 8.5, provided that the aqueous solution include phosphate buffer at a concentration of about 15 mM or less and about 5000 ppm sodium chloride. The present invention also provides a method for sterilizing and storing an ophthalmic device using an aqueous solution of the invention.

Abstract: The present invention relates to methods for disinfecting or cleaning a contact lens comprising contacting a contact lens with a formulation comprising a N-halogenated amino acid and a phase transfer agent for a time sufficient to disinfect or clean the lens. This specification further discloses a formulation for disinfecting a contact lens comprising an N-halogenated amino acid and a phase transfer agent.

Abstract: A polymeric biguanide composition comprising less than 18 mol % of terminal amine groups as measured by 13C NMR. The polymeric biguanide composition also is characterized by a relative increase in the molar concentration of terminal guanidine groups or terminal cyanoguanidino groups. The invention is also directed to ophthalmic compositions comprising the polymeric biguanide compositions. The polymeric biguanide compositions can be used as an antimicrobial component in an ophthalmic lens care solution, or as a preservative to in a pharmaceutical composition or other health care product.

Abstract: A multipurpose lens care solution comprising 0.005 wt. % to 1 wt. % of an anionic biopolymer, and an antimicrobial agent selected from 0.5 ppm to 2 ppm of poly(hexamethylene biguanide), 0.5 ppm to 2 ppm polyquaternium-1, or 1 ppm to 4 ppm alexidine. The lens care solution exhibits a ZO-1 immunostaining of HCEpiC similar to phosphate buffered saline for after thirty minutes of contact time with the solution. The lens care solution will also have a transepithelial electrical resistance (TEER) of HCEpiC within a 25% difference or less than phosphate buffered saline in Ohm/cm2 after one hour of contact time with a 3:1 dilution (solution:DMEM), or the ECIS electrode arrays exhibit a 25% difference or less than phosphate buffered saline in Ohm after one hour of contact time with a 1:1 dilution (solution:DMEM).

Abstract: A method of providing a polymerized ophthalmic lens in which a polymerized ophthalmic lens is heated with a packaging solution comprising about 100 ppm to about 3,000 ppm of a wetting agent after its polymerization, and the ophthalmic lens formulation not having the wetting agent prior to its polymerization.

Abstract: An aqueous solution for cleaning and disinfecting a contact lens comprising 0.5 ppm to 5 ppm of 1,1?-hexamethylene-bis[5-(2-ethylhexyl)biguanide; 0.5 ppm to 3 ppm ?-[4-tris(2-hydroxyethyl)-ammonium chloride-2-butenyl]poly[1-dimethyl ammonium chloride-2-butenyl]-?-tris(2-hydroxyethyl)ammonium chloride; 0.005 wt. % to 0.04 wt. % hyaluronic acid; a boric acid/borate buffer; and a nonionic surfactant selected from poloxamer, poloxamine or any combination thereof.

Abstract: The present application refers to pharmaceutical preparations comprising an active ingredient and a carrier wherein the carrier comprises an aqueous electrochemically activated salt solution.

Abstract: Antimicrobial agents, products and compositions incorporating the agents, and methods of using the compositions and products are provided. The antimicrobial agents comprise 1,2-cyclohexanedimethanol, 1,4-cyclohexanedimethanol, 2,2,4,4-tetramethyl-1,3-cyclobutanediol, or mixtures thereof. These agents have surprisingly been found to inhibit microbial growth at a much lower concentration than other glycols with known antimicrobial activity.

Abstract: The present invention relates to a method for reducing the occurrence of superficial punctate staining comprising the step of packaging, storing or contacting an uncoated ophthalmic lens comprising at least one polymeric wetting agent and polymer units derived from at least one silicone containing component in a solution comprising an osmolality of about 220 mOsm/kg or greater.

Abstract: An ophthalmic solution comprising a polyethoxylated glyceride in the range of 0.001 to about 10 percent by weight and a buffer agent. These solutions impart surprising comfort and wearability to contact lenses. At the same time the solutions provide good preservative capacity and do not increase protein deposit.

Abstract: An ophthalmic solution comprising a polyethoxylated glyceride in the range of 0.001 to about 10 percent by weight and a buffer agent. These solutions impart surprising comfort and wearability to contact lenses. At the same time the solutions provide good preservative capacity and do not increase protein deposit.

Abstract: An aqueous ophthalmic composition comprising a branched, glycerol monoalkyl compound and a fatty acid monoester. The fatty acid monoester comprises an aliphatic fatty acid portion having six to fourteen carbon atoms and an aliphatic hydroxyl portion. The composition will also have an osmolality in a range from 200 mOsmol/kg to 400 mOsmol/kg. The invention is also directed to a method of inhibiting the formation of foam in an aqueous ophthalmic composition that includes a surfactant as well as to a method of enhancing the biocidal efficacy of an aqueous ophthalmic composition containing a fatty acid monoester.

Abstract: The present invention provides solutions containing dexpanthenol in combination with xylitol, preferably further including a viscosity-enhancing agent to make solutions viscous so that the viscous solutions are not only capable of cleaning, disinfecting, and/or rinsing a contact lens in a lens case but also capable of cleaning and lubricating the contact lens directly in an eye. Such solutions can provide to the user an ability to clean and to rewet lenses anytime anywhere even without taking them out.

Abstract: A contact lens care solution comprising one or more alkyldimonium hydroxypropyl alkylglucosides of general formula I or general formula II wherein R is a straight or branched C8-C24alkyl; A is —CH2CH(OH)CH2N+(CH3)2R1X?, wherein R1 is a C8-C24alkyl and X? is a common counteranion, n is an average value from 1 to 6 and m is an average value from 1 to 2. The solution is formulated to clean and disinfect contact lenses or the solution is formulated as a rewet eye drop for use with contact lenses.

Abstract: The present invention relates to contact lens care product comprising dexpanthenol. The invention similarly relates to the usage of a contact lens care compositions of this kind for cleaning and optionally disinfecting contact lenses.

Abstract: The present invention relates to compositions and their use for the treatment of human skin, particularly facial skin, to alleviate the symptoms of cosmetic or determatologic skin conditions. The invention relates to compositions for treating and ameliorating skin conditions including acne, rosacea and wrinkling caused by photodamage or conditions related to aging, hormonal imbalances, hyper-pigmentation, melasma, keratosis or the like. The invention can also be used to treat conditions of the scalp such as dandruff. The present invention also relates to compositions that can be used to remove biofilms from contact lenses. More particularly, this invention relates to a composition comprising (a) one or more metasilicate; (b) one or more carbonate; (c) one or more glyconate; and (d) one or more sulfate. The composition may also contain (e) salts, e.g., sea salts and other additives or active agents.

Abstract: A multi-purpose contact lens care solution having high antimicrobial activity comprising, in an aqueous liquid medium, cetylpyridinium chloride and a non-ionic surfactant. In one embodiment of the invention, the non-ionic surfactant is a poly(oxypropylene)-poly(oxyethylene) block copolymer. The solution may optionally also include additional antimicrobial components, a buffer component, a viscosity inducing component, a surfactant, taurine, propylene glycol and/or a tonicity component. This solution additionally prevents losses in ocular tissue membrane integrity during contact lens wear.

Abstract: Ophthalmic compositions that comprise 0.1 ppm to 50 ppm of a cationic antimicrobial component selected from the group consisting of biguanides, polymeric biguanides, quaternium ammonium compounds and any one mixture thereof; 0.005 wt. % to 2 wt. % of an anionic biopolymer; and 0.01 wt. % to 2 wt. % of an amphoteric surfactant of general formula I wherein R1 is R or —(CH2)n—NHC(O)R, wherein R is a C8-C30alkyl optionally substituted with hydroxyl and n is 2, 3 or 4; R2 and R3 are each independently selected from C1-C4alkyl; R4 is a C2-C8alkylene optionally substituted with hydroxyl; and Y is CO2? or SO3. The invention is also direct to the use of the ophthalmic compositions to clean and disinfect contact lenses, and in particular, soft, silicone hydrogel contact lenses.

Abstract: A method of disinfecting a contact lens is provided, including the steps of preparing a disinfecting liquid which contains hydrogen peroxide and at least one metal phthalocyanine compound dispersed or dissolved in an aqueous medium, immersing the contact lens in the disinfecting liquid, and irradiating the disinfecting liquid in which the contact lens is immersed with a light.

Abstract: An buffered aqueous contact lens disinfecting solution having much lower concentration of disinfecting agents, and less irritating to the eye. The solutions have a tonicity of 200 to 450 mOsm/kg, a pH of between 6 and 8, and a concentration of chloride ions below 1500 ppm. Despite having less than 1 ppm of antimicrobial, the solutions are effective against C. albicans within 15 minutes of contact.

Abstract: Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms.

Abstract: The present invention relates to a detergent composition containing (a) 2 to 30% by weight of an inorganic alkali, (b) 0.5 to 20% by weight of at least one surfactant selected from an anionic surfactant and a nonionic surfactant, (c) 0.01 to 2% by weight (based on calcium ion) of a calcium salt, (d) 0.1 to 15% by weight of a calcium ion-sequestering agent, (e) 1 to 30% by weight of a water-soluble organic solvent and (f) 20 to 95% by weight of water.