Enzyme Component Of Specific Activity Or Source (e.g., Protease; Of Bacterial Origin, Etc.) Patents (Class 510/114)
  • Patent number: 9072712
    Abstract: An anti-microbial preservative for use in ophthalmic and dermatologic products. The preservative includes from about 0.005 wt. % to about 0.20 wt. % chlorite compound and from about 0.005 wt. % to about 0.05 wt. % peroxy compound. Additionally, the preservative does not generate chlorine dioxide within the pH range of 5.0-8.8. Also included are an antimicrobial ophthalmic and dermatologic compositions for direct application onto an eye or skin of a living being including from about 0.005 wt. % to about 0.20 wt. % chlorite compound and from about 0.005 wt. % to about 0.05 wt. % peroxy compound. Also included are methods for treating dryness of the eyes and skin disorders (e.g., wounds, burns, infections, ulcerations, psoriasis, etc.) and for disinfecting and cleansing contact lenses while in place upon an eye by applying the composition to the eye or to the contact lens.
    Type: Grant
    Filed: June 18, 2014
    Date of Patent: July 7, 2015
    Assignee: S.K. Pharmaceuticals, Inc.
    Inventor: Hampar L. Karagoezian
  • Patent number: 9005947
    Abstract: The present invention provides a novel ?-glucosidase nucleic acid sequence, designated bgl7, and the corresponding BGL7 amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding BGL7, recombinant BGL7 proteins and methods for producing the same.
    Type: Grant
    Filed: January 17, 2014
    Date of Patent: April 14, 2015
    Assignee: Danisco US Inc.
    Inventors: Nigel Dunn-Coleman, Michael Ward
  • Patent number: 8945900
    Abstract: The present invention relates to fungal serine protease variants, which comprise an amino acid substitution of valine at position 208 of the parent Fusarium equiseti Fe_RF6318 serine protease, wherein the position of the substitution corresponds to the amino acid sequence of the mature Fe_RF6318 enzyme defined in SEQ ID NO:2. The variants have improved thermal stability and/or detergent stability compared to the parent Fe_RF6318 enzyme. Preferably the substitution is V208I and more preferably the variants comprise additional amino acid changes which further increase the stability. Also disclosed are nucleic acid sequences encoding said protease variants as well as recombinant vectors and host cells for the production of the variants.
    Type: Grant
    Filed: October 28, 2011
    Date of Patent: February 3, 2015
    Assignee: AB Enzymes Oy
    Inventors: Kari Juntunen, Leena Valtakari, Nina Hakulinen, Marja Paloheimo
  • Patent number: 8859480
    Abstract: Detergent compositions containing high efficiency lipase enzymes and specific detergent formulations comprising less than 10 wt % zeolite and phosphate builder are described. Preferred formulations comprise surfactants selected from alkyl benzene sulphonates in combination with alky ethoxylated sulfates or MES or non-ionic surfactants.
    Type: Grant
    Filed: March 18, 2009
    Date of Patent: October 14, 2014
    Assignee: The Procter & Gamble Company
    Inventors: Neil Joseph Lant, Steven George Patterson
  • Patent number: 8802614
    Abstract: A hydrolytic enzyme is to be stabilized in a liquid surfactant preparation. This is achieved by using a component that stabilizes the hydrolytic enzyme and encompasses a multiply substituted benzenecarboxylic acid that has a carboxyl group on at least two carbon atoms of the benzene residue.
    Type: Grant
    Filed: January 25, 2013
    Date of Patent: August 12, 2014
    Assignee: Henkel AG & Co. KGaA
    Inventors: Petra Siegert, Marion Merkel, Hendrik Hellmuth, Timothy O'Connell, Karl-Heinz Maurer
  • Patent number: 8796009
    Abstract: A substrate or coating is provided that includes a protease with enzymatic activity toward a component of a biological stain. Also provided is a process for facilitating the removal of a biological stain is provided wherein an inventive substrate or coating including a protease is capable of enzymatically degrading of one or more components of the biological stain to facilitate biological stain removal from the substrate or said coating.
    Type: Grant
    Filed: June 21, 2010
    Date of Patent: August 5, 2014
    Assignees: Toyota Motor Engineering & Manufacturing North America, Inc., Toyota Motor Corporation
    Inventors: Hongfei Jia, Wei Song, Masahiko Ishii, Minjuan Zhang
  • Patent number: 8716208
    Abstract: A solid particulate laundry detergent composition including: (a) polyethylene glycol polymer including a polyethylene glycol backbone and polyvinyl acetate side chains, wherein the average molecular weight of the polyethylene glycol backbone is in the range of from 4,000 Da to 8,000 Da, wherein the molecular weight ratio of the polyethylene glycol backbone to the polyvinyl acetate side chains is in the range of from 1:1.2 to 1:2, and wherein the average number of graft sites per ethylene oxide units is in the range of from 0.2 to 0.4; (b) amylase with greater than 90% identity to the AA560 alpha amylase endogenous to Bacillus sp. DSM 12649 and including: (i) mutations at one or more of positions 9, 149, 182, 186, 202, 257, 295, 299, 323, 339 and 345; and (ii) mutations at four or more of positions 118, 183, 184, 195, 320 and 458; and (c) laundry detergent ingredients.
    Type: Grant
    Filed: March 1, 2011
    Date of Patent: May 6, 2014
    Assignee: The Procter & Gamble Company
    Inventors: Michelle Meek, Philip Frank Souter, Neil Joseph Lant, Alan Thomas Brooker, Nigel Patrick Somerville Roberts
  • Patent number: 8679818
    Abstract: The present invention provides a novel ?-glucosidase nucleic acid sequence, designated bgl7, and the corresponding BGL7 amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding BGL7, recombinant BGL7 proteins and methods for producing the same.
    Type: Grant
    Filed: December 17, 2012
    Date of Patent: March 25, 2014
    Assignee: Danisco US Inc.
    Inventors: Nigel Dunn-Coleman, Michael Ward
  • Patent number: 8592195
    Abstract: Novel fungal endoglucanases Ce15 and Ce112 are disclosed. The endoglucanases are conveniently produced by recombinant technology, and means for their production are described. The endoglucanases are used for treating cellulosic material, especially in textile industry, e.g. in biofinishing or biostoning. They may also be used in detergents, in animal feed and/or in pulp and paper industry, or in hydrolysis of lignocellulosic material for, e.g. bioethanol production.
    Type: Grant
    Filed: December 28, 2009
    Date of Patent: November 26, 2013
    Assignee: AB Enzymes Oy
    Inventors: Terhi Puranen, Leena Valtakari, Marika Alapuranen, George Szakacs, Pentti Ojapalo, Jari Vehmaanperä
  • Patent number: 8580720
    Abstract: The present invention relates to a laundry detergent composition comprising a glycosyl hydrolase and a benefit agent containing delivery particles, compositions comprising said particles, and processes for making and using the aforementioned particles and compositions.
    Type: Grant
    Filed: December 22, 2008
    Date of Patent: November 12, 2013
    Assignee: The Procter & Gamble Company
    Inventors: Jean-Pol Boutique, Nathalie Jean Marie-Louise Vanwyngaerden, Neil Joseph Lant, Philip Frank Souter, Eugene Steven Sadlowski, Genevieve Cagalawan Wenning
  • Patent number: 8580721
    Abstract: A solid particulate laundry detergent composition including: (a) substituted cellulosic polymer including carboxymethyl substituent groups, and having a degree of substitution (DS) of at least 0.55, and having a degree of blockiness (DB) of at least 0.35, and having a DS+DB is in the range of from 1.05 to 2.00; (b) amylase with greater than 90% identity to the AA560 alpha amylase endogenous to Bacillus sp. DSM 12649 and including: (i) mutations at one or more of positions 9, 149, 182, 186, 202, 257, 295, 299, 323, 339 and 345; and (ii) mutations at four or more of positions 118, 183, 184, 195, 320 and 458; and (c) laundry detergent ingredients.
    Type: Grant
    Filed: March 1, 2011
    Date of Patent: November 12, 2013
    Assignee: The Procter & Gamble Company
    Inventors: Michelle Meek, Philip Frank Souter, Neil Joseph Lant, Alan Thomas Brooker, Nigel Patrick Somerville Roberts
  • Patent number: 8535928
    Abstract: A novel protease comprising any one of (a) the amino acid sequence of SEQ ID NO: 1, (b) an amino acid sequence having deletion, substitution or addition of one to several amino acids in the amino acid sequence of SEQ ID NO: 1, (c) the amino acid sequence of SEQ ID NO: 3, and (d) an amino acid sequence having deletion, substitution or addition of one to several amino acids in the amino acid sequence of SEQ ID NO: 3, has a high activity under high temperature and high alkaline conditions, a high stability to protein denaturants and surfactants and high effectiveness as a protease used in detergents.
    Type: Grant
    Filed: July 30, 2009
    Date of Patent: September 17, 2013
    Assignee: Osaka University
    Inventors: Shigenori Kanaya, Tita Foophow, Kazufumi Takano, Yuichi Koga
  • Patent number: 8501448
    Abstract: The present invention relates to xyloglucanases belonging to family 44 of glycosyl hydrolases and having a relative xyloglucanase activity of at least 30% between pH 5 and pH 8 are derived from the genus Paenibacillus, especially from a strain of Paenibacillus polymyxa or Paenibacillus sp. The xyloglucanases exhibit high performance in conventional detergent compositions.
    Type: Grant
    Filed: December 12, 2012
    Date of Patent: August 6, 2013
    Assignee: Novozymes A/S
    Inventors: Kirk Schnorr, Martin Schulein, Per Lina Jorgensen
  • Patent number: 8354263
    Abstract: The present invention relates to xyloglucanases belonging to family 44 of glycosyl hydrolases and having a relative xyloglucanase activity of at least 30% between pH 5 and pH 8 are derived from the genus Paenibacillus, especially from a strain of Paenibacillus polymyxa or Paenibacillus sp. The xyloglucanases exhibit high performance in conventional detergent compositions.
    Type: Grant
    Filed: November 2, 2011
    Date of Patent: January 15, 2013
    Assignee: Novozymes A/S
    Inventors: Kirk Schnorr, Per Lina Jorgensen, Hanne Dela
  • Patent number: 8268763
    Abstract: The present invention provides a lens care kit for disinfecting and cleaning contact lenses. The lens care kit of the invention comprises a colored lens care solution including a colored protein and a proteolytic enzyme. The kit of the invention allows customers to visually identify when their lenses are disinfected, clean, and ready to wear. The invention relies upon a color change to indicate the completion of disinfection and cleaning of contact lenses.
    Type: Grant
    Filed: August 14, 2007
    Date of Patent: September 18, 2012
    Assignee: Novartis AG
    Inventors: Jennifer Dawn Lane, Mary Mowrey-McKee, Karen Belinda Sentell, Karen Frances Lindley
  • Patent number: 8097442
    Abstract: The invention provides laccases, polynucleotides encoding these enzymes, the methods of making and using these polynucleotides and polypeptides.
    Type: Grant
    Filed: April 21, 2010
    Date of Patent: January 17, 2012
    Assignee: Verenium Corporation
    Inventors: Tim S. Hitchman, Dan E. Robertson, Masao Hiraiwa, Yoko Phillips, Kevin A. Gray
  • Patent number: 8071351
    Abstract: The present invention relates to xyloglucanases belonging to family 44 of glycosyl hydrolases and having a relative xyloglucanase activity of at least 30% between pH 5 and pH 8 are derived from the genus Paenibacillus, especially from a strain of Paenibacillus polymyxa or Paenibacillus sp. The xyloglucanases exhibit high performance in conventional detergent compositions.
    Type: Grant
    Filed: May 13, 2010
    Date of Patent: December 6, 2011
    Assignee: Novozymes A/S
    Inventors: Kirk Schnorr, Martin Schulein, Hanne Dela, legal representative, Per Lina Jorgensen
  • Patent number: 7981654
    Abstract: The present invention provides novel cellulase fusion proteins, preparations of cellulase fusion proteins and compositions of cellulase fusion proteins. The present invention further provides cellulase expression vectors, host cells expressing cellulase and methods for preparing such vectors and cells. Uses of cellulases, cellulase preparations and cellulase compositions in the textile, detergent, pulp and paper industries are also provided.
    Type: Grant
    Filed: April 15, 2010
    Date of Patent: July 19, 2011
    Assignee: AB Enzymes Oy
    Inventors: Jari Vehmaanperä, Terhi Puranen, Leena Valtakari, Jarno Kallio, Marika Alapuranen, Marja Paloheimo, Pentti Ojapalo
  • Patent number: 7807434
    Abstract: The present invention provides a novel endoglucanase nucleic acid sequence, designated egl6, and the corresponding EGVI amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding EGVI, recombinant EGVI proteins and methods for producing the same.
    Type: Grant
    Filed: January 10, 2006
    Date of Patent: October 5, 2010
    Assignee: Danisco US Inc.
    Inventors: Nigel Dunn-Coleman, Frits Goedegebuur, Michael Ward, Jian Yao
  • Patent number: 7794997
    Abstract: This invention relates to an amylase derived from Bacillus horikoshii. The amylase has a preference for soluble substrates, shows substantial exo-amylase activity and has a pH optimum of about 9.8.
    Type: Grant
    Filed: December 10, 2009
    Date of Patent: September 14, 2010
    Assignee: Novozymes A/S
    Inventors: Tine Hoff, Shamkant Anant Patkar, Jeppe Wegener Tams
  • Patent number: 7771983
    Abstract: The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Grant
    Filed: December 4, 2009
    Date of Patent: August 10, 2010
    Assignee: Novozymos, Inc.
    Inventors: Nikolaj Spodsberg, Paul Harris, Randall Kramer
  • Patent number: 7741093
    Abstract: The present invention provides novel cellulase fusion proteins, preparations of cellulase fusion proteins and compositions of cellulase fusion proteins. The present invention further provides cellulase expression vectors, host cells expressing cellulase and methods for preparing such vectors and cells. Uses of cellulases, cellulase preparations and cellulase compositions in the textile, detergent, pulp and paper industries are also provided.
    Type: Grant
    Filed: April 29, 2005
    Date of Patent: June 22, 2010
    Assignee: AB Enzymes Oy
    Inventors: Jari Vehmaanperä, Terhi Puranen, Leena Valtakari, Jarno Kallio, Marika Alapuranen, Marja Paloheimo, Pentti Ojapalo
  • Patent number: 7659101
    Abstract: This invention relates to an amylase derived from Bacillus horikoshii. The amylase has a preference for soluble substrates, shows substantial exo-amylase activity and has a pH optimum of about 9.8.
    Type: Grant
    Filed: December 15, 2005
    Date of Patent: February 9, 2010
    Assignee: Novozymes A/S
    Inventors: Tine Hoff, Shamkant Anant Patkar, Jeppe Wegener Tams
  • Patent number: 7527959
    Abstract: The present invention provides an endoglucanase nucleic acid sequence, designated egl7, and the corresponding EGVII amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding EGVII, recombinant EGVII proteins and methods for producing the same.
    Type: Grant
    Filed: January 10, 2006
    Date of Patent: May 5, 2009
    Assignee: Danisco US Inc., Genencor Division
    Inventors: Nigel Dunn-Coleman, Frits Goedegebuur, Michael Ward, Jian Yao
  • Publication number: 20080095754
    Abstract: An ophthalmic composition that includes an epithelium cell stabilizer component. The epithelium cell stabilizer component may be one or more of diglycine, triglycine, tetraglycine, pentaglycine. The invention is also directed to a method of treating or preventing dry eye comprising administering an effective amount of the ophthalmic composition to the eye.
    Type: Application
    Filed: September 13, 2007
    Publication date: April 24, 2008
    Inventors: Susan E. Burke, Erning Xia, Kai Kwok, Stephen R. Davio
  • Patent number: 7344871
    Abstract: The present invention provides a novel ?-glucosidase nucleic acid sequence, designated bgl5, and the corresponding BGL5 amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding BGL5, recombinant BGL5 proteins and methods for producing the same.
    Type: Grant
    Filed: June 7, 2005
    Date of Patent: March 18, 2008
    Assignee: Genencor International, Inc.
    Inventors: Nigel Dunn-Coleman, Frits Goedegebuur, Michael Ward, Jian Yao
  • Patent number: 7300782
    Abstract: The invention relates to a new glycosyl hydrolases with an amyloltic activity and nucleic acids coding for said gylcosyl hydrolases, A PCR-based method for identifying and preparing new gylcosyl hydrolases from metagenome DNA and several possible technical uses for such glycosyl hydrolases with an amylolytic activity. Washing and cleaning products containing such enzymes, and methods and possible uses corresponding thereto are particularly interesting.
    Type: Grant
    Filed: June 21, 2004
    Date of Patent: November 27, 2007
    Assignee: B.R.A.I.N. Biotechnology Research and Information Network AG
    Inventors: Roland Breves, Karl-Heinz Maurer, Jürgen Eck, Patrick Lorenz, Holger Zinke
  • Patent number: 7294498
    Abstract: A thermostable glycosidase enzymes derived from various Thermococcus, Staphylothermus and Pyrococcus organisms is disclosed. The enzymes are produced from native or recombinant host cells and can be utilized in the food processing industry, pharmaceutical industry and in the textile industry, detergent industry and in the baking industry.
    Type: Grant
    Filed: April 9, 2002
    Date of Patent: November 13, 2007
    Assignee: Verenium Corporation
    Inventors: Edward J. Bylina, Ronald V. Swanson, Eric J. Mathur, David E. Lam
  • Patent number: 7273742
    Abstract: The present invention provides a novel ?-glucosidase nucleic acid sequence, designated bgl3, and the corresponding BGL3 amino acid sequence. The invention also provides expression vectors and host cells comprising a nucleic acid sequence encoding BGL3, recombinant BGL3 proteins and methods for producing the same.
    Type: Grant
    Filed: May 16, 2005
    Date of Patent: September 25, 2007
    Assignee: Genencor International, Inc.
    Inventors: Nigel Dunn-Coleman, Frits Goedegebuur, Michael Ward, Jian Yao
  • Patent number: 7271244
    Abstract: The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated nucleic acids encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acids as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: February 4, 2005
    Date of Patent: September 18, 2007
    Assignee: Novozymes, Inc.
    Inventors: William D. Dotson, Jennifer Greenier, Hanshu Ding
  • Patent number: 7144845
    Abstract: The present invention relates to, for example, compounds of formula (VI) useful in the manufacture of anti-inflammatory androstane derivatives.
    Type: Grant
    Filed: June 7, 2004
    Date of Patent: December 5, 2006
    Assignee: Glaxo Group Limited
    Inventors: Keith Biggadike, Steven John Coote, Rosalyn Kay Nice
  • Patent number: 7135442
    Abstract: The present invention relates to contact lens care product comprising dexpanthenol. The invention similarly relates to the usage of a contact lens care compositions of this kind for cleaning and optionally disinfecting contact lenses.
    Type: Grant
    Filed: January 11, 2002
    Date of Patent: November 14, 2006
    Assignee: Novartis AG
    Inventors: Peter Schwind, Anton Scherer
  • Patent number: 7112429
    Abstract: The invention provides a thermal tolerant mannanase that is a member of the glycoside hydrolase family. The invention further discloses this mannanase as ManA. ManA has been isolated and characterized from Acidothermus cellulolyticus. The invention further provides recombinant forms of the identified ManA. Methods of making ManA polypeptides, including fusions, variants, and derivatives, are also disclosed. Methods of using mannanase A, including for the processing of food and for use in food stuffs as bulking agents and the like, are also disclosed.
    Type: Grant
    Filed: July 28, 2001
    Date of Patent: September 26, 2006
    Assignee: Midwest Research Institute
    Inventors: Shi-You Ding, William S. Adney, Todd B. Vinzant, Michael E. Himmel
  • Patent number: 7041793
    Abstract: Detergent composition comprising fusion protein comprising a cellulose binding domain and a domain having a high binding affinity for another ligand. Preferably, the domain having a high binding affinity is directed at a Benefit Agent.
    Type: Grant
    Filed: November 29, 2001
    Date of Patent: May 9, 2006
    Assignee: Unilever Home & Personal Care USA Division of Conopco, Inc.
    Inventors: Paul James Davis, Neil James Parry
  • Patent number: 6955907
    Abstract: A novel alkaline protease VapK suitable for a laundry detergent is disclosed. The gene vapk coding for the protease VapK, the recombinant plasmids containing said gene, and the transformed V. metshnikovii KS1 (pSBCm) with said recombinant plasmid are also disclosed. In addition, a process for producing the protease VapK is disclosed.
    Type: Grant
    Filed: January 14, 2000
    Date of Patent: October 18, 2005
    Assignee: Cheil Jedang Corporation
    Inventors: Ghee Hong Jin, Hyoung Suk Kim, Hyune Mo Rho, Hyune Whan Lee
  • Patent number: 6939702
    Abstract: Certain variants of Lipolase (wild-type Humicolalanuginosa lipase) have a particularly good first-wash performance in a detergent solution. The variants should comprise one or more substitutions with positive amino acids near the N-terminal in the three-dimensional structure. The variants should further comprise a peptide addition at the C-terminal and/or should meet certain limitations on electrically charged amino acids at positions 90-101 and 210.
    Type: Grant
    Filed: March 30, 2000
    Date of Patent: September 6, 2005
    Assignee: Novozymes A/S
    Inventors: Jesper Vind, Allan Svendsen, Shamkant Anant Patkar, Kim Vilbour Andersen, Dorte Aaby Halkier, Kirsten Bojsen
  • Patent number: 6921655
    Abstract: It is an object of the present invention to provide enzymes that have high endoglucanase activity and yet exhibit high activity even under alkaline conditions, and genes encoding the same. The enzyme according to the invention has the following properties: a) exhibiting endoglucanase activity; and b) capable of completely removing fuzz from regenerated cellulose fabrics at a concentration of 1 mg of the protein/L or below. The enzyme of the invention having endoglucanase activity is a protein comprising the amino acid sequence as shown in SEQ ID NO: 1, 3, 5, 7, 9 or 11; a modified protein thereof exhibiting endoglucanase activity; or a homologue of the protein or the modified protein.
    Type: Grant
    Filed: October 25, 1999
    Date of Patent: July 26, 2005
    Assignee: Meiji Seika Kaisha, Ltd.
    Inventors: Yuko Nakamura, Tatsuki Moriya, Yuko Baba, Koji Yanai, Naomi Sumida, Tomoko Nishimura, Kouichirou Murashima, Akitaka Nakane, Takashi Yaguchi, Jinichiro Koga, Takeshi Murakami, Toshiaki Kono
  • Patent number: 6919428
    Abstract: Fusion protein comprising a cellulose binding domain and a domain having a high binding affinity for another ligand and detergent compositions comprising such fusion proteins.
    Type: Grant
    Filed: December 20, 2000
    Date of Patent: July 19, 2005
    Assignee: Unilever Home Products and Care USA division of Conopco, Inc.
    Inventors: Paul James Davis, Neil James Parry
  • Patent number: 6759228
    Abstract: An alkaline protease having the following properties; a gene encoding the same; a microorganism producing the same; and washing compositions containing the same; (i) acting over a broad pH value range of 4 to 13 and achieving, at pH 6 to 12, 80% or more the activity at the optimum pH value; (ii) when treated at 40° C. for 30 minutes, being stable over a pH value range of 6 to 11; (iii) having an isoelectric point of about 8.9 to 9.1; and (iv) having casein digesting activity that is not inhibited by oleic acid. The alkaline protease of the present invention is highly stable to various surface active agents and fatty acids, and exhibits high stability to oxidizing agents, and is therefore useful as an enzyme to be used in detergents for automatic dishwashers and laundry detergents, both containing bleaching components.
    Type: Grant
    Filed: August 3, 2001
    Date of Patent: July 6, 2004
    Assignee: Kao Corporation
    Inventors: Mikio Takaiwa, Mitsuyoshi Okuda, Katsuhisa Saeki, Hiromi Kubota, Jun Hitomi, Yasushi Kageyama, Shitsuw Shikata, Masafumi Nomura
  • Patent number: 6743616
    Abstract: The invention relates to mutant &agr;-amylases that may be produced at high yield from recombinant microorganisms.
    Type: Grant
    Filed: October 9, 2001
    Date of Patent: June 1, 2004
    Assignee: Kao Corporation
    Inventors: Hiroyuki Araki, Keiji Endo, Hiroshi Hagihara, Kazuaki Igarashi, Yasuhiro Hayashi, Katsuya Ozaki
  • Patent number: 6682923
    Abstract: The invention relates to novel xylanase activity (XA) proteins and nucleic acids. The invention further relates to the use of the XA proteins in the process of pulp bleaching.
    Type: Grant
    Filed: May 12, 2000
    Date of Patent: January 27, 2004
    Assignee: Xencor
    Inventors: Jörg Bentzien, Bassil I. Dahiyat
  • Patent number: 6630340
    Abstract: The present invention relates to xyloglucanases belonging to family 5 of glycosyl hydrolases are derived from strains of Paenibacillus, especially from strains of Paenibacillus pabuli. The xyloglucanases show high performance in conventional liquid detergent compositions.
    Type: Grant
    Filed: March 1, 2001
    Date of Patent: October 7, 2003
    Assignee: Novozymes A/S
    Inventors: Reinhard Wilting, Mads Eskelund Bjørnvad, Markus Sakari Kauppinen, Martin Schulein
  • Patent number: 6617143
    Abstract: The present invention relates to isolated polypeptides having glucanotransferase activity and isolated nucleic acid sequences encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing and using the polypeptides.
    Type: Grant
    Filed: October 13, 2000
    Date of Patent: September 9, 2003
    Assignee: Novozymes A/S
    Inventor: Shiro Fukuyama
  • Publication number: 20030125221
    Abstract: Contact lenses are simultaneously cleaned and disinfected by contacting the lenses with an aqueous system containing an antimicrobial agent and a proteolytic enzyme for a period sufficient to clean and disinfect the lenses. The aqueous solutions have suitable osmotic values which do not substantially inhibit the activity of the antimicrobial agent.
    Type: Application
    Filed: November 5, 2002
    Publication date: July 3, 2003
    Applicant: Bausch & Lomb Incorporated
    Inventors: Mary F. Mowrey-McKee, David W. Proud, George E. Minno
  • Publication number: 20030118472
    Abstract: A system and a method for disinfecting and cleaning ophthalmic devices such as contact lenses is provided. The system involves the use of an active microbicidal solution generated just prior to use by the reaction of an iodide salt with hydrogen peroxide in the presence of a peroxidase. Such a system is particularly useful for disinfecting contact lenses.
    Type: Application
    Filed: July 31, 2002
    Publication date: June 26, 2003
    Inventors: Mary Mowrey McKee, Marzenna Alicja Sills
  • Patent number: 6566114
    Abstract: Novel mannanases comprising e.g. an amino acid sequence as shown in positions 31-330 of SEQ ID NO:2 or their homologues may be derived from e.g. Bacillus sp. I633, or may be encoded by polynucleotide molecules comprising a nucleotide sequence as shown in SEQ ID NO: 1 from nucleotide 91 to nucleotide 990, polynucleotide molecules that encode a polypeptide that is at least 65% identical to the amino acid sequence of SEQ ID NO: 2 from amino acid residue 31 to amino acid residue 330, or degenerate nucleotide sequences thereof. The mannanases are alkaline and are useful e.g. in cleaning compositions, in a fracturing fluid useful to fracture a subterranean formation, for modifying plant material, and for treatment of cellulosic fibers.
    Type: Grant
    Filed: June 24, 1999
    Date of Patent: May 20, 2003
    Assignee: Novozymes, A/S
    Inventors: Markus Sakari Kauppinen, Martin Schülein, Kirk Schnorr, Lene Nonboe Andersen, Mads Eskelund Bjørnvad
  • Patent number: 6544763
    Abstract: Enzyme granules are provided in which an enzyme is rapidly eluted, without insoluble remnants, and generation of powdery dust is suppressed, and which granules have a property such that classification phenomenon generated among the granules in a detergent composition is less likely to take place, in a case where the enzyme granules are formulated together with other components in a detergent. The enzyme granule comprise (A) water-insoluble substance and or a slightly water-soluble substance; (B) a water-soluble binder; and (C) an enzyme. A dye may also be present for coloring. The content of (A) component is 45% by weight or more, and the enzyme granules have an average particle size of from 150 to 500 &mgr;m and a bulk density of from 500 to 1,000 g/L, and have a structure such that more amount of (B) component is present near the surface of the enzyme granules than in the inner portion thereof. The enzyme granule may be aggregated to form an enzyme granule aggregate.
    Type: Grant
    Filed: October 31, 2001
    Date of Patent: April 8, 2003
    Assignee: Kao Corporation
    Inventors: Yoshinobu Imaizumi, Koichi Ohori, Itsuro Tsukahara, Hiroyuki Yamashita
  • Patent number: 6528464
    Abstract: The invention provides a method for inhibiting the binding of a biguanide antimicrobial in aqueous solution to a hydrogel in contact with said solution comprising providing in said solution an amount of cyclodextrin sufficient to inhibit sorption of the biguanide antimicrobial to a hydrogel.
    Type: Grant
    Filed: August 17, 2001
    Date of Patent: March 4, 2003
    Assignee: Bausch & Lomb Incorporated
    Inventors: Erning Xia, Richard V. Smerbeck, Rebecca Franklin
  • Patent number: 6500658
    Abstract: An isolated or purified polypeptide having xyloglucanase activity which is obtained from a strain of the genus Malbranchea and has xyloglucanase activity in the pH range 4-11, measured at 50° C.; and/or a molecular mass of 25±10 kDa, as determined by SDS-PAGE; and/or an isoelectric point (pI) in the range 3-5; and/or an N-terminal sequence Ala-Asp-Phe-Cys-Gly-Gln-Xaa-Asp-Ser-Glu-Gln-Ser-Gly-Pro-Tyr-Ile-Val-Tyr-Asn-Asn-Leu is useful in industrial applications such as in laundry detergent compositions and for treatment of textiles.
    Type: Grant
    Filed: September 1, 2000
    Date of Patent: December 31, 2002
    Assignee: Novozymes, A/S
    Inventors: Wenping Wu, Martin Schulein, Markus Sakari Kauppinen, Mary Ann Stringer
  • Patent number: 6448062
    Abstract: A composition for simultaneous cleaning and decontaminating a device. The composition is a per-compound oxidant in an amount effective for decontaminating the device and an enzyme in an amount effective for cleaning the device. The device may be a medical device such as an endoscope or kidney dialyzer and a plurality of devices can be cleaned using the same composition. The composition may additionally contain a corrosion inhibitor in an amount effective to prevent corrosion of a metal, a chelator, a buffer, a dye and combinations thereof.
    Type: Grant
    Filed: October 29, 1999
    Date of Patent: September 10, 2002
    Assignee: Metrex Research Corporation
    Inventors: Stanley William Huth, Zhi-Jian Yu