Abstract: Compositions are provided that have at least two of three active ingredients. The active ingredients maybe a salt having a cation N?C8-C16 alkanoyl-L di-basic amino acid —C1-C4 alkyl ester, a glycerol monoester of a fatty acid and a sugar ester of a fatty acid. The compositions are useful in methods of killing or inhibiting planktonic bacteria or fungi and bacteria or fungi embedded in a biofilm and prevention of biofilm formation on surfaces. The composition may further comprise a hydrogel and a benefit agent such as an antibiotic that can be solubilized by the hydrogel and supplied to the biofilm matrix by the active ingredients of the composition. Devices such as chronic wound coverings coated with the composition are also provided. Methods of preserving products with the composition are also provided.

Abstract: The invention relates to an aqueous ophthalmic solution comprising 0.00001 to about 10.0 percent by weight L-histidine, 0.0001 to 3.0 percent by weight hydrogen peroxide, and optionally 0.1 to 500 parts per million of a preservative that provides superior preservative efficacy especially as against fungal microbes. These solutions may be employed in various ways including cleaning contact lenses, rinsing lenses while in the eye, storing lenses and in delivering active pharmaceutical agents to the eye.

Abstract: The invention relates to a contact lens cleaning agent which contains 0.001 to 5% w/w of an organic peroxy acid as well as to the use of organic peroxy acids for contact lens cleaning purposes.

Abstract: A pharmaceutical formulation that is effective in adversely affecting the viability of microorganisms or in inhibiting their growth and that provides better safety and/or comfort to the users comprises a polysaccharide, a source of hydrogen peroxide, and an anti-oxidant. The formulation can further comprise a chelating agent and/or an ophthalmically active agent for treating or controlling a disease or disorder of the eye. The formulation may be used to treat, clean, disinfect, store, wet, or rewet contact lenses.

Abstract: The present invention relates to ophthalmic compositions comprising a pH between about 6 and about 8 and about 50 to about 1000 ppm hydrogen peroxide, about 100 ppm to about 2000 ppm of at least one chlorite compound and about 20 to 100 ppm of at least one saturated, polymeric quaternium salt. The ophthalmic compositions of the present invention display improved antifungal efficacy against fusarium solani.

Abstract: An buffered aqueous contact lens disinfecting solution having much lower concentration of disinfecting agents, and less irritating to the eye. The solutions have a tonicity of 200 to 450 mOsm/kg, a pH of between 6 and 8, and a concentration of chloride ions below 1500 ppm. Despite having less than 1 ppm of antimicrobial, the solutions are effective against C. albicans within 15 minutes of contact.

Abstract: The present invention relates to contact lens care product comprising dexpanthenol. The invention similarly relates to the usage of a contact lens care compositions of this kind for cleaning and optionally disinfecting contact lenses.

Abstract: A composition for disinfecting a contact lens comprising an effective disinfecting amount of hydrogen peroxide and a surfactant comprising a copolymer of hydrophobe and hydrophile blocks the structure: HO-(hydrophobe)x-(hydrophile)y-(hydrophobe)x-H or HO-(hydrophile)y-(hydrophobe)x-(hydrophile)y-H where x and y are integers reflecting the respective hydrophile and hydrophobe blocks of said copolymer; and the hydrophile component of the block copolymer constitutes less than 50 weight percent of the block copolymer. The block copolymer has a Ross-Miles foam height (ASTM designation D-1173-53; 0.1%, at 50° C.) of less than 1 mm.

Abstract: A method for improving the wettability of a medical device involves: (a) providing a medical device formed from a monomer mixture comprising a hydrophilic device-forming monomer including a copolymerizable group and an electron donating moiety, and a second device-forming monomer including a copolymerizable group and a reactive functional group; and (b) contacting a surface of the medical device with a wetting agent including a proton donating moiety reactive with the functional group provided by the second lens-forming monomer and that complexes with the electron donating moiety provided by the hydrophilic lens-forming monomer.

Abstract: A method for improving the wettability of a medical device involves: (a) providing a medical device formed from a monomer mixture comprising a hydrophilic device-forming monomer including a copolymerizable group and an electron donating moiety, and a second device-forming monomer including a copolymerizable group and a reactive functional group; and (b) contacting a surface of the medical device with a wetting agent including a proton donating moiety reactive with the functional group provided by the second lens-forming monomer and that complexes with the electron donating moiety provided by the hydrophilic lens-forming monomer.

Abstract: The present invention is directed to new and improved solutions for packaging contact lenses and to methods for treating contact lenses with such solutions to improve the comfort of the lenses during wear. In particular, the present invention is directed to packing solutions comprising certain non-ionic surfactants containing a poly(oxyalkylene) copolymer and having a molecular weight of 4000 to 30,000. Such surfactants are retained on the surface of an unused lens for extended periods of time, resulting in surface modification that persists in the eye, thereby providing significant improvement in the wetting properties of fresh contact lenses used for the first time and, moreover, even several hours after lens insertion, preventing dryness and improving lubricity.

Abstract: Methods of reducing the adherence of lenses to hydrophobic packing materials using compounds of Formula I are disclosed herein, where R1-R12, a, b, z, x, q, m, and n are defined herein.

Abstract: A method and composition for disinfecting a contact lens is disclosed. The method includes treating a lens with an aqueous solution having reduced toxicity to the eye which contains an effective amount of a monoperphthalic acid compound in a concentration of less than about 0.5% by weight of the solution. The lens disinfecting solution is capable of disinfecting contact lenses without irritating the eye due to reduced toxicity of the composition.

Abstract: An ophthalmic composition having regulated viscosity characterized in that it contains polyoxyethylene polyoxypropylene glycol or polyoxyethylene-polyoxypropylene-substituted ethylenediamine in association with a pharmaceutically acceptable thickener and has a viscosity ranging from 1 cps to 8 cps at 200° C., which is useful as contact lens wetting solution, eye drops, cleaning agent, and preservative for contact lenses.

Abstract: The present invention is a liquid protectant which protects and extends the life of anti-reflective, hydrophobic (water repellent) and mirror coatings and all types of plastic lenses from scratches, abrasions and “wear-off” of the coatings by upgrading the performance of cleaning liquids and provides the highest level of protection against abrasion as well as optical clarity, ease of cleaning and anti-static properties. The present invention apparatus and method of producing the same is used to both clean and coat all types of optical lenses which includes a coating in the nature of an optical lens coating which bonds to the exterior surface of an anti-reflective coated optical lens to create a barrier between the anti-reflective coating and the cleaning surfaces.

Abstract: The present invention is directed to new and improved solutions for packaging contact lenses and to methods for treating contact lenses with such solutions to improve the comfort of the lenses during wear. In particular, the present invention is directed to packing solutions comprising certain non-ionic surfactants containing a poly(oxyalkylene) copolymer and having a molecular weight of 4000 to 30,000. Such surfactants are retained on the surface of an unused lens for extended periods of time, resulting in surface modification that persists in the eye, thereby providing significant improvement in the wetting properties of fresh contact lenses used for the first time and, moreover, even several hours after lens insertion, preventing dryness and improving lubricity.

Abstract: A solution for contact lenses which comprises an amino acid type cationic surfactant and at least one nonionic surfactant.

Abstract: Multi-purpose solutions for contact lens care provide substantial lens wearer/user comfort and/or acceptability. Such solutions include an aqueous liquid medium; an antimicrobial component, preferably a biguanide polymer present in an amount of less than about 5 ppm; a surfactant component, preferably a poly(oxyethylene)-poly(oxypropylene) block copolymer surfactant, in an effective amount; a phosphate buffer component in an effective amount; a viscosity inducing component, preferably selected from cellulosic derivatives, in an effective amount; and a tonicity component in an effective amount. Such solutions have substantial performance, comfort and-acceptability benefits, which, ultimately, lead to ocular health advantages and avoidance of problems caused by contact lens wear.

Abstract: A solution for contact lenses which comprises an amino acid type cationic surfactant and at least one nonionic surfactant.

Abstract: The invention is directed to compositions and methods used as in-the-eye and/or out-of-eye inhibitors of proteinaceous deposits on hydrophilic contact lenses. Compositions of the present invention comprise moderately charged polyquaternium polymers that selectively bind to hydrophilic contact lenses to block the binding of proteinaceous materials. Compositions of the present invention may be used in multipurpose cleaning solutions for contact lenses and can eliminate the need for special enzyme cleaners and the like for removing proteinaceous materials.

Abstract: Contact-lens disinfectant containing(a) magnesium monoperphthalate and(b) sodium cumenesulphonate,(c) sodium alkylbenzenesulphonate,(d) isotridecanol ethoxylate and(e) methylhydroxyethylcellulose,and packaging and a process for the preparation thereof.

Abstract: A method of cleaning and disinfecting a contact lens, comprising the steps of: preparing a disinfectant which is an aqueous solution containing an iodine-complex polymer, and a diluent which is an aqueous solution containing ethylenediamine tetraacetic acid and/or soluble salts thereof, and a nonionic surface active agent; mixing the disinfectant and the diluent to provide a mixed solution, such that an available iodine concentration of the mixed solution immediately after mixing is in a range of 0.01-50 ppm, and such that concentrations of the ethylenediamine tetraacetic acid and/or the soluble salts thereof, and the nonionic surface active agent in the mixed solution are in a range of 0.0001-1.0 w/v % and in a range of 0.01-1.0 w/v %, respectively; and immersing the contact lens in the mixed solution for cleaning and disinfecting the contact lens, resulting in gradual reduction of the available iodine remaining in the mixed solution, by the ethylenediamine tetraacetic acid and/or the soluble salts thereof.

Abstract: A detergent composition having excellent color care properties when used to launder colored fabnrics. The composition comprises a dye transfer inhibiting polymer comprising one or more monomeric units containing at least one .dbd.N--C(.dbd.O) with the proviso that the dye transfer inhibiting agent does not comprise an -oxide group and a water soluble sunscreen.

Abstract: Compositions and methods useful for disinfecting a contact lens are disclosed. The present methods comprise contacting a contact lens with a liquid medium containing an effective amount of an oxidative disinfectant component at conditions to effectively disinfect the contact lens. The contacting occurs in the presence of a color indicator component which is soluble in the liquid medium and is adapted to provide a color indication of the presence of the oxidative disinfectant component in the liquid medium. The color indicator component comprises an effective amount of a transition metal component which is redox active, has an oxidized state of a first color and a reduced state of a different second color and a polyanionic component in an amount effective to inhibit the staining of the contact lens by the transition metal component.

Abstract: A method of simultaneously cleaning and disinfecting a contact lens is disclosed, which method comprises the steps of: (a) preparing a cleaning solution for the contact lens comprising an effective amount of a proteolytic enzyme, 15-60 w/v % (percent by weight/volume) of propylene glycol, 10-60 w/v % of glycerine, and water, a total content of the propylene glycol and glycerine being in a range of 30-80 w/v %; (b) diluting the cleaning solution with a disinfecting or storing liquid for the contact lens which contains an ionic antimicrobial agent, so as to provide a dilution; and (c) immersing the contact lens in the dilution.

Abstract: It is an object of the present invention to provide a cleaning and disinfecting solution for a contact lens to be cleaned and disinfected simultaneously in a simplified manner with high efficiency. It is also an object of the present invention to provide a method of cleaning and disinfecting the contact lens wherein the cleaning and disinfection of the contact lens can be effected simultaneously in a short period of time by using the above-indicated cleaning and disinfecting solution. The above objects may be obtained according to one aspect of the present invention which provided a cleaning and disinfecting solution for a contact lens comprising an effective amount of proteolytic enzyme, 60-80% w/v % of propylene glycol, 10-35% w/v % of glycerine, and water, a total content of propylene glycol and glycerine being in the range of 70% to 95 w/v %.

Abstract: An ophthalmically acceptable solution and a method useful for disinfecting and/or cleaning a contact lens. The solution comprises an oxidizing agent and a polyvinyl pyrrolidone having a molecular weight ranging from 10,000 to 100,000 daltons and reactive towards a chlorite oxidizing agent. The end groups of the polyvinyl pyrrolidone are preferably aldehydes. The oxidizing agent of this invention preferably is selected from the group comprising chlorine oxides. The solution preferably has a pH ranging from about 6 to about 8.5. The method of the invention comprises the steps of forming this solution and then contacting a contact lens with the solution.

Abstract: A composition for cleaning and wetting contact lenses comprising a non-amine polyethylenoxide-containing copolymeric material having a hydrophilic-lipophile balance (HLB) of at least about 18, a surface active agent having cleaning activity for contact lens deposits and having HLB values of less than 18, and a wetting agent. Preferred embodiments of the present invention include those having from about 0.001 to about 10 weight percent of a non-amine polyethyleneoxy-containing materials, particularly those selected from: ethoxylated glucose derivatives, ethoxylated ethers of sorbitol, copolymers comprising ethyleneoxy and propyleneoxy monomeric units, and mixtures thereof. Preferred embodiments further include from about 0.001 to about 5 weight percent of the surface active agent and from about 0.1 to about 10 weight percent of a wetting agent selected from: cellulosic materials, silicone polymers containing an alkyleneoxide side chain, polyvinyl alcohols, polyvinyl pyrrolidones, and mixtures thereof.

Abstract: Compositions containing a stable, liquid, ophthalmically acceptable enzyme and methods involving the combined use of these compositions with a polymeric antimicrobial agent are disclosed for the simultaneous cleaning and disinfecting of contact lens. Methods for a daily use regimen are also disclosed.

Abstract: Compositions and methods useful for disinfecting a contact lens are disclosed. The present methods comprise contacting a contact lens with a liquid medium containing an effective amount of an oxidative disinfectant component at conditions to effectively disinfect the contact lens. The contacting occurs in the presence of a color indicator component which is soluble in the liquid medium and is adapted to provide a color indication of the presence of the oxidative disinfectant component in the liquid medium. The color indicator component comprises an effective amount of a transition metal component which is redox active, has an oxidized state of a first color and a reduced state of a different second color and a polyanionic component in an amount effective to inhibit the staining of the contact lens by the transition metal component.

Abstract: Compositions and methods are provided for cleaning and wetting of contact lenses, especially rigid, gas-permeable contact lenses. The compositions comprise low molecular weight polyalkylene oxide modified siloxanes, which are particularly effective in removing lipids from the surface of contact lenses.

Abstract: A composition for cleaning contact lenses comprises a silicone surface active agent having cleaning activity for contact lens deposits. The silicone surface active agent has at least one side chain including a radical ionizable in aqueous solution.

Abstract: A method for using a composition including a neutralizing system and a sequestering agent which prevents the accumulation of inorganic deposits on contact lenses, particularly when used regularly in a conventional hydrogen peroxide disinfection regimen. The neutralizing system includes at least one reducing agent, a reductase, or both. The sequestering agent preferably is gluconic acid, a polymetaphosphate or their salts. Sodium hexametaphosphate is the most preferred sequestering agent; catalase is the most preferred agent for use as the neutralizing system.

Abstract: Compositions and methods are provided for cleaning and wetting of contact lenses, especially rigid, gas-permeable contact lenses. The compositions comprise low molecular weight polyalkylene oxide modified siloxanes, which are particularly effective in removing lipids from the surface of contact lenses.