Abstract: An aqueous, concentrated neutral detergent composition for use in cleaning medical instruments and metal components (parts, tools, utensils, vessels, equipment, and surfaces) having scale control and corrosion inhibition properties when diluted to about 1/40 ounce per gallon to about 1/10 ounce per gallon in potable water. In addition, the concentrate may be applied directly to metal surfaces, such as stainless steel, to remove rust and other stains, without causing any additional corrosion or other damage to the metal surface.

Abstract: A composition is described having a first nonionic alkoxylated alcohol surfactant having an HLB value ranging from about 10 to about 15, a second nonionic alkoxylated alcohol surfactant having an HLB value ranging from about 16 to 20, an aqueous solvent, and optionally, a bio-film permeation agent. A total of the first surfactant and the second surfactant in the composition ranges from about 2 to about 20 percent by weight of a total weight of the composition, and a ratio of the second surfactant to the first surfactant in the composition ranges from about 2:1 to about 4:1. A method for treating contaminated surfaces of surgical waste management equipment is also described. The method includes rinsing surfaces of the equipment with water to remove water soluble contaminants and waste material. A rinse solution is applied to the surfaces of the equipment to provide a residual film thereon.

Abstract: The liquid composition is based on surfactants and enzymes, and is particularly useful for manual cleaning of instruments. In manual and ultrasonic application the composition in use concentration shows low foaming and gives a cleaning solution which is not cloudy at least at a temperature in the range from 16° C. to 40° C. In addition, the composition has good cleaning efficacy over a broad temperature range (20 to 55° C.) and shows good material compatibility.

Abstract: The invention discloses methods of making and uses for wide spectrum disinfectants including as components an alcohol, O-phenylphenol, chlorhexidine gluconate, nonoxynol-9, benzalkonium chloride, and deionized double distilled water wherein on a weight/volume ratio the alcohol comprises from 50% to 80%, the O-phenylphenol comprises from 0.1% to 0.8%, the chlorhexidine gluconate comprises from 0.1% to 1%, the nonoxynol-9 comprises from 0.02% to 1%, and the benzalkonium chloride comprises from 0.15% to 1%.

Abstract: The invention relates to the use of agents, which contain at least one disinfection system based on selected organic peracids and combinations of peracids, in automatically functioning systems, in which fragile medical appliances, in particular, endoscopes, are cleaned and disinfected. According to the invention, the appliances are brought into contact with an aqueous disinfection agent solution after they have been treated and/or at the same time they are being treated with an aqueous cleaning solution. The invention also relates to cleaning and disinfection agents and methods which are all suited for carrying out this purpose.

Abstract: A cleaning solution for automatic biochemical analyzers includes: at least one anionic surfactant, at least one nonionic surfactant, an alkali metal hydroxide, an alkali metal citrate, and a buffering agent stabilizing the pH value above 13.0. In some embodiments, the cleaning solution provides low residual rate of proteins, low residual rate of lipids, desirable within-batch repeatability in clinical testing, low level of cross-contamination, and low level of reactant deposit after cleaning, without affecting test results of the biochemical analyzer. In some embodiments, the cleaning solution has no corrosive effects on the liquid path and reaction cup of the analyzer. The ingredients of the cleaning solution may also be biodegradable.

Abstract: The present invention is drawn to methods of treating disease or injury. In particular, the invention provides methods for treating viral infections, bacterial infections, fungal infections, and cancerous tissue. The methods include the administration of an aqueous composition that can comprise an aqueous vehicle, including water, from 0.0001 wt % to 10.0 wt % of a peroxygen, and optionally, an alcohol. Additionally, from 0.0001 ppm to 50,000 ppm by weight of a transition metal based on the aqueous vehicle content can also be present. Alternatively or additionally, the transition metal can be in the form of a colloidal transition metal, such as colloidal silver or alloy thereof.

Abstract: The present invention relates to compositions including a water soluble magnesium salt, water soluble calcium salt, and gluconate, which have a beneficial effect on corrosion during cleaning. The present compositions can reduce corrosion of a variety of surfaces including glass, aluminum, chrome, copper, and steel. The present invention also relates to methods employing these compositions.

Abstract: A method for cleaning contaminated surfaces of surgical waste management equipment. The method includes rinsing surfaces of the equipment with water to remove water soluble contaminants and waste material. A rinse solution is applied to the surfaces of the equipment to provide a residual film thereon. The rinse solution includes a first nonionic alkoxylated alcohol surfactant having an HLB value ranging from about 10 to about 15, a second nonionic alkoxylated alcohol surfactant having an HLB value ranging from about 16 to 20, an aqueous solvent, and optionally, a bio-film permeation agent. A total of the first surfactant and the second surfactant in the composition ranges from about 2 to about 20 percent by weight of a total weight of the composition, and a ratio of the second surfactant to the first surfactant in the composition ranges from about 2:1 to about 4:1.

Abstract: A composition having a first nonionic alkoxylated alcohol surfactant having an HLB value ranging from about 10 to about 15, a second nonionic alkoxylated alcohol surfactant having an HLB value ranging from about 16 to 20, an aqueous solvent, and optionally, a bio-film permeation agent. A total of the first surfactant and the second surfactant in the composition ranges from about 2 to about 20 percent by weight of a total weight of the composition, and a ratio of the second surfactant to the first surfactant in the composition ranges from about 2:1 to about 4:1.

Abstract: The present invention is drawn to dispensing devices and systems which can be used to store and/or dispense a disinfectant solution. The device can include a first compartment and a second compartment. The first compartment can include a first liquid composition, which includes a transition metal or alloy thereof. The second compartment is separated from the first compartment and can contain a second liquid composition that includes a peroxygen. The first and second liquid compositions are formulated to be combined so as to yield a resultant disinfectant solution. The disinfectant solution can be used to disinfect a variety of surfaces and even liquid compositions.

Abstract: A novel method for cleaning dental and medical instruments is disclosed, in which a cleaning solution including a low-residue corrosion inhibitor is used not only in a wash stage of the cleaning cycle, but also in at least one subsequent rinse cycle, to optimize both cleaning and rust prevention. A novel cleaning solution particularly suited to this method has a neutral to alkaline pH and comprises in aqueous solution a low-foaming surfactant and a corrosion inhibitor selected from the group of C4-C16 alkyl pyrrolidones and C1-C18 alkylamines.

Abstract: The present invention is drawn to disinfectant compositions, which are human safe, e.g., food grade or food safe. In one embodiment, an aqueous disinfectant composition can comprise an aqueous vehicle, including water, from 0.001 wt % to 10.0 wt % of a peroxygen, and an alcohol. Additionally, from 0.001 ppm to 50,000 ppm by weight of a transition metal based on the aqueous vehicle content can also be present. The composition can be substantially free of aldehydes. Alternatively or additionally, the transition metal can be in the form of a colloidal transition metal, such as colloidal silver or alloy thereof.

Abstract: The present invention is drawn to disinfectant or sterilant compositions, which are human safe, e.g., food grade or food safe. In one embodiment, an aqueous disinfectant or sterilant composition can comprise an aqueous vehicle, including water, from 0.001 wt % to 50 wt % of a peracid, and from 0.001 wt % to 25 wt % of a peroxide. Additionally, from 0.001 ppm to 50,000 ppm by weight of a transition metal based on the aqueous vehicle content can also be present. The composition can be substantially free of aldehydes. Alternatively or additionally, the transition metal can be in the form of a colloidal transition metal.

Abstract: The present invention is drawn to methods and compositions for use in partially or fully decontaminating surfaces which have been contaminated with chemical or biological warfare agents. The invention includes contacting the contaminated surface with a composition capable of ameliorating the negative effects caused by the warfare agent. In one embodiment, the composition includes an aqueous vehicle of water and from 0.001 wt % to 40.0 wt % of a peroxygen. Additionally, the composition can include from 0.001 ppm to 50,000 ppm by weight of a transition metal based on the aqueous vehicle content. Optionally, an alcohol can be included in the composition. In one embodiment, the transition metal can be in the form of a colloidal transition metal, such as colloidal silver.

Abstract: The present invention relates to cleaning compositions comprising conversion agents and methods of using them. The conversion agents of the present invention comprise water insoluble compounds such as metal oxides, metal hydroxides, and combinations thereof. The compositions can be substantially free of a builder, e.g., a chelating agent, sequestrant, and/or threshold agent, while still achieving effective soil removal, and reduced spotting, scaling or combinations thereof.

Abstract: Provided are a method of cleaning an endoscope, a washing machine and a washing machine for endoscope, which can effectively clean an endoscope while preventing the endoscope from deterioration. The electrolytic cell 11 can produce from tap water acidic water with pH of 2 to 5 and the residual chlorine concentration of 50 to 300 ppm. A tank for acidic water 14 can store acidic water, in which part thereof can be fed to a tank of diluting acidic water 17 and the rest thereof can be fed to a feed section of concentrated water 20. A water feed section for dilution 16 can feed water for dilution to the tank of diluting acidic water 17. The tank of diluting acidic water 17 can add water for dilution from the water feed section for dilution 16 to part of the acidic water from the tank for acidic water 14 to adjust diluted acidic water to pH of 2.3 to 5.7 and the residual chlorine concentration of 10 to 60 ppm.

Abstract: The liquid composition is based on surfactants and enzymes, and is particularly useful for manual cleaning of instruments. In manual and ultrasonic application the composition in use concentration shows low foaming and gives a cleaning solution which is not cloudy at least at a temperature in the range from 16° C. to 40° C. In addition, the composition has good cleaning efficiacy over a broad temperature range (20 to 55° C.) and shows good material compatibility.

Abstract: An aqueous, concentrated neutral detergent composition for use in cleaning medical instruments and metal components (parts, tools, utensils, vessels, equipment, and surfaces) having scale control and corrosion inhibition properties when diluted to about 1/40 ounce per gallon to about 1/10 ounce per gallon in potable water. In addition, the concentrate may be applied directly to metal surfaces, such as stainless steel, to remove rust and other stains, without causing any additional corrosion or other damage to the metal surface.

Abstract: The present disclosure is directed to methods and compositions for clearing and cleaning enteral feeding tubes. More particularly, the composition is an ingestible gel composition that comprises enzymes for degrading buildup in enteral feeding tubes, carrageenan, and divalent metal ions or a source thereof. The carrageenan present in the composition stabilizes the enzymes at room temperatures, allowing for long-term storage of the composition. Upon injecting the gelled composition into the feeding tube, body heat from the patient melts the gel, and the enzymes are released to act on debris present in the feeding tube.

Abstract: The present invention is drawn to disinfectant systems and methods which can be used to produce a disinfectant solution. The system can include a first liquid composition and a second liquid composition. The first liquid composition comprises from 0.0005 ppm to 100,000 ppm by weight of a transition metal or alloy and an alcohol, and the second liquid composition comprises water and a peroxygen compound. The first and second liquid compositions are formulated to be combined so as to yield a resultant disinfectant solution. The disinfectant solution can be used to disinfect a variety of surfaces and even liquid compositions.

Abstract: CFC replacement solvent compositions, methods of using the same and methods of making the same. These compositions meet or exceed the solvency, flammability, and compatibility requirements for CFC's while providing similar or improved environmental and toxicological properties. These solvent compositions have applications including, but not limited to, oxygen handling, refrigeration or heat pumps, electronics, implantable prosthetic devices, and optical equipment.

Abstract: A composition for the removal of biofilms from substrate surfaces formed by reacting: (a) one or more quaternary halide surfactants with (b) a source of reactive bromine ions in the ratio of 1 halide ion forming part of the quaternary surfactant to 0.05 to 8 moles of bromine ions in aqueous solution.

Abstract: The invention relates to the use of agents, which contain at least one disinfection system based on selected organic peracids and combinations of peracids, in automatically functioning systems, in which fragile medical appliances, in particular, endoscopes, are cleaned and disinfected. According to the invention, the appliances are brought into contact with an aqueous disinfection agent solution after they have been treated and/or at the same time they are being treated with an aqueous cleaning solution. The invention also relates to cleaning and disinfection agents and methods which are all suited for carrying out this purpose.

Abstract: A novel method for cleaning dental and medical instruments is disclosed, in which a cleaning solution including a low-residue corrosion inhibitor is used not only in a wash stage of the cleaning cycle, but also in at least one subsequent rinse cycle, to optimize both cleaning and rust prevention. A novel cleaning solution particularly suited to this method has a neutral to alkaline pH and comprises in aqueous solution a low-foaming surfactant and a corrosion inhibitor selected from the group of C4-C16 alkyl pyrrolidones and C1-C18 alkylamines.

Abstract: The present invention is drawn to disinfectant or sterilant compositions and associated methods of use. In one embodiment, an aqueous disinfectant or sterilant composition can comprise an aqueous vehicle, including water, from 0.001 wt % to 50 wt % of a peracid, and from 0.001 wt % to 25 wt % of a peroxide. Additionally, from 0.001 ppm to 50,000 ppm by weight of a transition metal based on the aqueous vehicle content can also be present. The disinfectant composition can be used in the manufacture of disinfectant wipes, disinfectant gels, and disinfectant fogs. In one embodiment, the composition can be substantially free of aldehydes. Alternatively or additionally, the transition metal can be in the form of a colloidal transition metal.

Abstract: The present invention relates to cleaning compositions comprising conversion agents and methods of using them. The conversion agents of the present invention comprise water insoluble compounds such as metal oxides, metal hydroxides, and combinations thereof. The compositions can be substantially free of a builder, e.g., a chelating agent, sequestrant, and/or threshold agent, while still achieving effective soil removal.

Abstract: The present invention relates to compositions and methods employing a water soluble magnesium compound. In certain embodiments, the composition includes water and water soluble magnesium compound, but lacks other materials commonly used in cleaning compositions. The methods and compositions can provide magnesium ion at predefined ratios to calcium ion in water, such as magnesium ion in a molar amount equal to or in excess over a molar amount of calcium ion. A water soluble magnesium salt including an anion of a water soluble calcium salt is more effective than a magnesium salt with an anion of a water insoluble calcium salt. These compositions can be used for reducing lime scale or precipitate formation from hard water, removing soap scum, or the like.

Abstract: The invention relates to the use of agents, which contain at least one disinfection system based on selected organic peracids and combinations of peracids, in automatically functioning systems, in which fragile medical appliances, in particular, endoscopes, are cleaned and disinfected. According to the invention, the appliances are brought into contact with an aqueous disinfection agent solution after they have been treated and/or at the same time they are being treated with an aqueous cleaning solution. The invention also relates to cleaning and disinfection agents and methods which are all suited for carrying out this purpose.

Abstract: A method of treating the surfaces of medical instruments which are contaminated with prions includes contacting the surface with a composition containing a source of peroxide ions, such as hydrogen peroxide, at a molar concentration of at least 1.5M peroxide (equivalent to approximately 5% hydrogen peroxide) and preferably, about 2M peroxide (approximately 7% hydrogen peroxide). The composition is optionally in the form of a gel. The composition is retained in contact with the surfaces for about 1-2 hours until all or substantially all prion contamination is removed.

Abstract: The invention relates to an alkaline disinfecting and cleaning composition which comprises one or more selected quaternary ammonium salts, one or more selected alcohol alkoxylates and one or more alkylamines. By exact choice of the components a composition is provided which can be formulated as concentrate and, as dilute aqueous ready-to-use solution, has good cleaning efficiency combined with good microbicidal activity.

Abstract: Ductwork used for the supply of potable water in dental surgeries is prone to undesirable build up of biofilm and associated bacteria. These may be combated effectively by applying to the ductwork a composition comprising: a metal silicate or silicate complex; a metal phosphate or polyphosphate or orthophosphoric acid; and a non-ionic or amphoteric surfactant.

Abstract: The present invention is drawn to disinfectant or sterilant compositions, which are human safe, e.g., food grade or food safe. In one embodiment, an aqueous disinfectant or sterilant composition can comprise an aqueous vehicle, including water, from 0.001 wt % to 50 wt % of a peracid, and from 0.001 wt % to 25 wt % of a peroxide. Additionally, from 0.001 ppm to 50,000 ppm by weight of a transition metal based on the aqueous vehicle content can also be present. The composition can be formulated to include only food-grade ingredients. Alternatively or additionally, the transition metal can be in the form of a colloidal transition metal.

Abstract: The invention discloses methods of making and uses for wide spectrum disinfectants including as components an alcohol, O-phenylphenol, chlorhexidine gluconate, nonoxynol-9, benzalkonium chloride, and deionised double distilled water wherein on a weight/volume ratio the alcohol comprises from 50 to 80%, the O-phenylphenol comprises from 0.1% to 0.8%, the chlorhexidine gluconate comprises from 0.01 to 1%, the nonoxynol-9 comprises from 0.02 to 1%, and the benzalkonium chloride comprises from 0.15 to 1%.

Abstract: A composition having a first nonionic alkoxylated alcohol surfactant having an HLB value ranging from about 10 to about 15, a second nonionic alkoxylated alcohol surfactant having an HLB value ranging from about 16 to 20, an aqueous solvent, and optionally, a bio-film permeation agent. A total of the first surfactant and the second surfactant in the composition ranges from about 2 to about 20 percent by weight of a total weight of the composition, and a ratio of the second surfactant to the first surfactant in the composition ranges from about 2:1 to about 4:1.

Abstract: A composition having a first nonionic nonylphenol surfactant having an HLB value ranging from about 10 to about 15, a second nonionic nonylphenol surfactant having an HLB value ranging from about 16 to 20, an aqueous solvent, and optionally, a bio-film permeation agent. A total of the first surfactant and the second surfactant in the composition ranges from about 2 to about 20 percent by weight of a total weight of the composition, and a ratio of the second surfactant to the first surfactant in the composition ranges from about 2:1 to about 4:1.

Abstract: The invention relates to a method for cleaning a contaminated medical instrument including the step of immersing the instrument in a solution containing an enzyme based cleaning composition including a “hospital grade disinfectant”. Compositions useful for cleaning contaminated medical instruments in accordance with the method include an enzyme, a quat biocide and an “activity protector”, which may be for example, enzyme stabilizers, enzyme stabilizing systems, micelle formation modifiers and inhibitors, and combinations thereof.

Abstract: A method of treating the surfaces of medical instruments which are contaminated with prions includes contacting the surface with a composition containing a source of peroxide ions, such as hydrogen peroxide, at a molar concentration of at least 1.5M peroxide (equivalent to approximately 5% hydrogen peroxide) and preferably, about 2M peroxide (approximately 7% hydrogen peroxide). The composition is optionally in the form of a gel. The composition is retained in contact with the surfaces for about 1–2 hours until all or substantially all prion contamination is removed.

Abstract: Methods and compositions for a concentrated alkaline disinfectant. The disinfectant includes a quaternary ammonium salt, a guanidine derivative, an alcohol ethoxylate with between 5 and 7 EO units, alkylamine, an acid, and aromatic alcohol.

Abstract: A non-toxic enzymatic detergent for use in cleaning surgical instruments and the like which have a large build-up of bio-residue thereon and which need specialty cleaning in order to avoid both hardened bio-residue and certain fluid traces from the instruments for both operating accuracy as well as sterilization requirements.

Abstract: The invention relates to ecologically-acceptable agent for treating pathogenic germs on surfaces, instruments and in fluids, comprising synergistic mixtures of aromatic hydroxybenzoic acids and phenols with a broad spectrum of action. The above is active against hydrophilically-sheathed and -unsheathed viruses as well as lipophilic bacteria and yeasts and is thus applicable in medicine, industry and commercial animal raising.

Abstract: A low pH disinfectant composition comprises an aqueous composition of a phenolic compound, an organic acid, and/or a dispersing surfactant and/or solvent. The disinfectant solution can be concentrated, or more preferably diluted ready to use, and is very effective in eradicating fungi including Aspergillus niger.

Abstract: A method of treating the surfaces of medical instruments which are contaminated with prions includes contacting the surface with a composition containing a source of peroxide ions, such as hydrogen peroxide, at a molar concentration of at least 1.5M peroxide (equivalent to approximately 5% hydrogen peroxide) and preferably, about 2M peroxide (approximately 7% hydrogen peroxide). The composition is optionally in the form of a gel. The composition is retained in contact with the surfaces for about 1–2 hours until all or substantially all prion contamination is removed.

Abstract: A surface which carries a material which is infected with prions is cleaned with an alkaline cleaning solution to remove as much proteinaceous material as possible from the surface. The cleaning agent is an alkaline cleaning agent which attacks prions remaining on the surface and which attacks prions removed from the surface during the cleaning step. After the cleaning solution is drained, a solution of surfactants, buffers, and heavy metal free corrosion inhibitors is circulated over the surface at 50°–60° C. The surfactants disperse and unclump the prion-contaminated material. A strong oxidant, preferably peracetic acid, is added to the solution to bring the peracetic acid concentration to 1,000–2,500 ppm. The peracetic acid or other strong oxidant attacks the prions, particularly the unclumped prion strands, deactivating the prions. After rinsing and drying, the surface may be wrapped in a microbe impermeable barrier and subjected to terminal sterilization, such as steam autoclaving.

Abstract: A method of cleaning a metered dose spray device, and a cleaning composition for such cleaning, prevent the device from becoming clogged with medication. The method includes removing the aerosol can containing the medication from the actuator, placing an aerosol can containing a cleaning composition in the actuator, and dispensing the cleaning solution through the actuator. The residual medication is thereby removed from the actuator. A sufficiently small quantity of cleaning composition remains in the actuator so that the cleaning composition itself will not clog the actuator. Additionally, the cleaning composition is non-toxic, so that residual cleaning composition remaining in the actuator will not harm the user when a subsequent dose of medication is dispensed.

Abstract: A method for improving the wettability of a medical device involves: (a) providing a medical device formed from a monomer mixture comprising a hydrophilic device-forming monomer including a copolymerizable group and an electron donating moiety, and a second device-forming monomer including a copolymerizable group and a reactive functional group; and (b) contacting a surface of the medical device with a wetting agent including a proton donating moiety reactive with the functional group provided by the second lens-forming monomer and that complexes with the electron donating moiety provided by the hydrophilic lens-forming monomer.

Abstract: The invention relates to an aqueous composition comprising in combination an alkyl pyrrolidone, such as a C8-C18 linear alkyl pyrrolidone, and an alkyl polysaccharide such as an alkyl polyglucoside, and a method of .enhancing the efficacy of an enzyme containing composition for use in cleaning medical instruments comprising the step of including in said composition an alkyl pyrrolidone and an alkyl polysaccharide. The methods and compositions of the present invention may further include at least one enzyme such as proteases, lipases, amylases, and cellulases.

Abstract: A two-part disinfecting systems, as well as disinfecting compositions and methods for making and using the same. The two-part disinfecting system contains a first part and a second part adapted to be mixed to yield an aqueous disinfecting composition, wherein the first part comprises a chlorite and the second part comprises an acid and an optional oxidizable colorant, and wherein the first part, the second part, or both the first and second parts comprise an alpha olefin sulfonate.

Abstract: The invention relates to the use of agents, which contain at least one disinfection system based on selected organic peracids and combinations of peracids, in automatically functioning systems, in which fragile medical appliances, in particular, endoscopes, are cleaned and disinfected. According to the invention, the appliances are brought into contact with an aqueous disinfection agent solution after they have been treated and/or at the same time they are being treated with an aqueous cleaning solution. The invention also relates to cleaning and disinfection agents and methods which are all suited for carrying out this purpose.

Abstract: Removal of water-insoluble organic residues from inorganic surfaces can be accomplished in aqueous cleaning solutions containing an oxidant at a preselected temperature wherein the pH is adjusted with respect to the isoelectric point of the surface material to be removed so that the pH is above the pK, and the isoelectric point of the surface for acid materials, and below the PKa and the isoelectric point of the surface for basic materials. Surfactants can also be added to the cleaning solution.