C=o Other Than As Ketone Or Aldehyde, Attached Directly Or Indirectly To Phosphorus Patents (Class 514/120)
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Patent number: 6337324Abstract: The invention relates to pharmaceutical compositions for topical administration comprising a topically acceptable antiviral substance and an antiinflammatory glucocorticoid in a pharmaceutically acceptable carrier. The pharmaceutical composition can be used in the prophylactic and curative treatment of herpesvirus infections in mammals including man. The invention also relates to the use of a combination of a topically acceptable antiviral substance and an antiinflammatory glucocorticoid for the manufacture of a medicament for said prophylactic and curative treatment.Type: GrantFiled: March 8, 1996Date of Patent: January 8, 2002Assignee: Medivir, ABInventors: Johan Georg Harmenberg, Ann Harriet Margareta Kristofferson
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Patent number: 6335026Abstract: A solid pesticidal composition containing acephate is stabilized by adding thereto at least one stabilizer selected from the group consisting of boron oxide, metaboric acid, aluminum oxide and the calcined product of synthetic silicon dioxide.Type: GrantFiled: March 31, 1994Date of Patent: January 1, 2002Assignee: Sumitomo Chemical Co., Ltd.Inventors: Yasuyuki Katayama, Toshiro Ohtsubo, Daniel C. Heffernan
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Patent number: 6329356Abstract: Therapeutic compounds and methods for modulating amyloid deposition in a subject, whatever its clinical setting, are described. Amyloid deposition is modulated by the administration to a subject of an effective amount of a therapeutic compound comprising a phosphonate group and a carboxylate group, a congener thereof, or a pharmaceutically acceptable salt or ester thereof. In preferred embodiments, an interaction between an amyloidogenic protein and a basement membrane constituent is modulated.Type: GrantFiled: April 8, 1999Date of Patent: December 11, 2001Assignees: Neurochem, Inc., Queen's University At KingstonInventors: Walter A. Szarek, Xianqi Kong
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Publication number: 20010047690Abstract: An acceleration sensor comprises a fixed case member and a cover assembly collectively defining a closed space in which the oscillation plate and the piezoelectric element received therein. The oscillation plate and the piezoelectric element are oscillatably supported by a supporting portion formed on the central bottom portion of the fixed case member.Type: ApplicationFiled: June 5, 2001Publication date: December 6, 2001Inventors: Hiroyuki Baba, Hideki Matsumoto
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Publication number: 20010041692Abstract: Phospholipid-HETE derivatives, compositions and methods of use are disclosed. The compounds are particularly useful for treating dry eye.Type: ApplicationFiled: June 5, 2001Publication date: November 15, 2001Inventors: Gustav Graff, Peter G. Klimko
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Publication number: 20010038825Abstract: Pulmonary function may be increased and pulmonary disorders treated by administering pharmaceutical formulations consisting essentially of phosphatidyl glycerol (PG) and a pharmaceutically acceptable carrier. Pulmonary disorders that may be treated by these methods and formulations include respiratory distress syndrome, asthma, and chronic bronchitis.Type: ApplicationFiled: February 5, 2001Publication date: November 8, 2001Inventor: Robert Duncan Hite
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Patent number: 6303589Abstract: The present invention relates to fungicidally effective compositions containing at least one pentacyclic triterpene compound.Type: GrantFiled: December 8, 1998Date of Patent: October 16, 2001Assignee: Micro Flo CompanyInventors: Jan Glinski, Keith L. Branly
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Patent number: 6288046Abstract: The present invention relates to phosphonic acid derivatives that inhibit N-Acetylated &agr;-Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions comprising such derivatives, and methods of using such derivatives to inhibit NAALADase activity, to treat a glutamate abnormality and to treat a prostate disease in an animal.Type: GrantFiled: April 26, 1999Date of Patent: September 11, 2001Assignee: Guilford Pharmaceuticals Inc.Inventors: Paul F. Jackson, Keith M. Maclin, Kevin L. Tays, Barbara S. Slusher
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Patent number: 6288047Abstract: A method of treating an individual with an immune system with decreased activity by administering an effective amount of a lipid preparation derived from a natural source and enriched to contain at least 10% (w/w) phosphatidic acid (PA) is disclosed.Type: GrantFiled: March 23, 2000Date of Patent: September 11, 2001Assignee: Modus Biological Membranes Ltd.Inventors: Meir Shinitzky, Avner Shenfeld
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Patent number: 6245754Abstract: The present invention relates to the preparation and biological activity of 3-deoxy-D-myo-inositol ether lipid analogs as inhibitors of phosphatidylinositol-3-kinase signaling and cancer cell growth. The compounds of the present invention are useful as anti-tumor agents which effectively inhibit the growth of mammalian cells.Type: GrantFiled: June 25, 1999Date of Patent: June 12, 2001Inventors: Alan P. Kozikowski, Lixin Qioa, Garth Powis
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Patent number: 6218435Abstract: A method of reducing hair growth in a mammal includes applying, to an area of skin from which reduced hair growth is desired, a dermatologically acceptable composition containing a suppressor of the metabolic pathway for the conversion of glucose to acetyl-CoA.Type: GrantFiled: July 17, 1998Date of Patent: April 17, 2001Inventors: James Henry, Gurpreet Ahluwalia, Douglas Shander
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Patent number: 6197759Abstract: Osteoblast-specific mitogens and drugs containing such compounds can be used for treating metabolic bone diseases. These compounds include lysophosphatidylic acid derivatives selected from the group consisting of compounds of formula: wherein R1=alkenyl or alkynyl having from 6 to 24 carbon atoms; n=0-12; X=oxygen or NH; the compounds (all-cis-5,8,11,14)-eicosatetraenoic acid 2-hydroxy-3-phosphonooxypropyl ester; cis-9, cis-12-octadecadienoic acid 2-hydroxy-3-phosphonooxypropyl ester; (all-cis-9,12,15)-octadecatrienoic acid 2-hydroxy-3-phosphonooxypropyl ester; cis-9-octadecenoic acid 2-hydroxy-3-phosphonooxypropyl ester; and erucic acid 2-hydroxy-3-phosphonooxypropylester being excluded, and the physiologically tolerable salts, esters, optically active forms, and racemates of said compounds, and derivatives of said compounds, salts, esters, optically active forms and racemates which can be metabolized in vivo to yield the corresponding compound of formula (I).Type: GrantFiled: April 11, 2000Date of Patent: March 6, 2001Assignee: Roche Diagnostics GmbHInventors: Angelika Esswein, Lothar Kling
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Patent number: 6184214Abstract: A pharmaceutical composition is provided comprising an effective amount of a phosphoenolpyruvate compound of the formula: wherein R1 and R2 are independently H, alky, alkenyl, alkoxy (except where applied to OR1), cycloalkyl, aryl, or aralkyl and Z1 and Z2 are independently OR1, or a pharmacologically acceptable salt thereof together with a pharmaceutically acceptable carrier.Type: GrantFiled: July 6, 1999Date of Patent: February 6, 2001Assignee: ITC Research LimitedInventors: Albina V. Dogadina, Igor E. Gourevitch, Boris I. Ionine
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Patent number: 6177412Abstract: An insecticidal composition includes (1) at least one compound of formula (I): wherein R1 is bromine, chlorine, methyl, or ethyl, R2 is bromine, chlorine, or ethyl, R3 is hydrogen, halogen, or trifluoromethyl, X is —O—, —S—, or —NH—, and n is 2, 3, or 4, and (2) at least one compound of formula (II): wherein R and R1 independently are an alkyl, alkenyl, or alkynyl group containing up to 6 carbon atoms, R2 is hydrogen, an alkyl group containing 1 to 18 carbon atoms, a cycloalkyl group containing 3 to 8 carbon atoms, an alkenyl group containing 2 to 18 carbon atoms, or an alkynyl group containing 3 to 18 carbon atoms, R3 is hydrogen or an alkyl group containing 1 to 6 carbon atoms, and Y is —O— or —S—. A method for killing insects such as the tobacco budworm and other Lepidopteran pests of cotton includes applying an insecticidally effective amount of such a composition to an area to be treated.Type: GrantFiled: May 28, 1999Date of Patent: January 23, 2001Assignee: Valent U.S.A. CorporationInventors: Robert T. Kincade, David East
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Patent number: 6174874Abstract: The invention encompasses the novel class of compounds represented by formula I which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases.Type: GrantFiled: September 17, 1999Date of Patent: January 16, 2001Assignee: Merck Frosst Canada & Co.Inventors: Zhaoyin Wang, Claude Dufresne, Yves Leblanc, Chun Sing Li, Jacques Y. Gauthier, Cheuk K. Lau, Michel Therien, Patrick Roy
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Patent number: 6153181Abstract: Disclosed is a substantially water-free insecticidal granular bait suitable for controlling crawling insects such as cockroaches and ants. The bait includes an insecticide, several feeding stimulants which are typically carbohydrates and proteins, and a lipid. These bait compositions are in granular form, which are useful for application in hard-to-reach areas and are particularly useful in wet conditions, as well as hot, dry areas.Type: GrantFiled: September 3, 1999Date of Patent: November 28, 2000Assignee: Ecolab Inc.Inventors: Thomas D. Nelson, Douglas G. Anderson, S. John Barcay
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Patent number: 6150345Abstract: The present invention provides a method for promoting the survival of myelin producing cells, in particular SCs and oligodendrocytes. Other embodiments of the present invention are directed to therapeutic methods, utilities, and other related uses.Type: GrantFiled: September 15, 1998Date of Patent: November 21, 2000Assignee: Regents of the University of CaliforniaInventors: Jerold J. M. Chun, Joshua A. Weiner
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Patent number: 6136797Abstract: The present invention concerns new lipid derivatives of phosphonocarboxylic acids of the general formula I, ##STR1## in which the meaning of the symbols is elucidated in the description, tautomers thereof and their physiologically tolerated esters and salts of inorganic or organic bases as well as processes for the production thereof and pharmaceutical agents containing these compounds.Type: GrantFiled: August 27, 1998Date of Patent: October 24, 2000Inventors: Harald Zilch, Dieter Herrmann, Hans-George Opitz, Gerd Zimmermann
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Patent number: 6054444Abstract: The present invention relates to phosphonic acid derivatives that inhibit N-Acetylated .alpha.-Linked Acidic Dipeptidase (NAALADase) enzyme activity, pharmaceutical compositions comprising such derivatives, and methods of using such derivatives to inhibit NAALADase activity, to treat a glutamate abnormality and to treat a prostate disease in an animal.Type: GrantFiled: April 24, 1997Date of Patent: April 25, 2000Assignee: Guilford Pharmaceuticals Inc.Inventors: Paul F. Jackson, Keith M. Maclin, Kevin L. Tays, Barbara S. Slusher
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Patent number: 6051564Abstract: The invention is to a method for the treatment of withdrawal symptoms selected from the group consisting of nausea, sweating, shaking, substance craving and hot flushes.Type: GrantFiled: February 24, 1999Date of Patent: April 18, 2000Assignee: Modus Biological Membranes Ltd.Inventors: Avner Shenfeld, Meir Shinitzky
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Patent number: 6030961Abstract: This invention relates to compositions for and methods of treating, preventing or ameliorating cancer and other proliferative diseases as well as methods of inducing wound hearing, treating cutaneous ulcers, treating gastrointestinal disorders, treating blood disorders such as anemias, immunomodulation, enhancing recombinant gene expression, treating insulin-dependent patients, treating cystic fibrosis patients, inhibiting telomerase activity, treating virus-associated tumors, especially EBV-associated tumors, modulating gene expression and in particular, augmenting expression of tumor suppressor genes, inducing tolerance to antigens, treating, preventing or ameliorating protozoan infection, or inhibiting histone deacetylase in cells. The compositions of the invention are to and the methods of the invention use oxyalkalene phosphate compounds.Type: GrantFiled: March 11, 1997Date of Patent: February 29, 2000Assignees: Bar-Ilan Research & Development Co., Ltd., Mor Research Applications Ltd.Inventors: Abraham Nudelman, Ada Rephaeli
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Patent number: 6017905Abstract: The present invention is directed to compounds useful for the regulation of cholesterol of Formula I, methods for using them and pharmaceutical compositions thereof, ##STR1## wherein Ar and Ar.sup.1 are each independently selected from unsubstituted or substituted phenyl which substituents are from 1-5 in number and are each independently selected from alkyl, alkoxy, hydroxy, halogen, nitro, trifluoromethyl, COOH, and COOalkyl;X is --NH--, --O--, --S--, or --(CH.sub.2).sub.0-4 --, andR is hydrogen, alkyl, or phenyl.Type: GrantFiled: June 9, 1998Date of Patent: January 25, 2000Assignee: Warner-Lambert CompanyInventors: William Howard Roark, Bruce David Roth
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Patent number: 6013272Abstract: Chemically stable, insecticidally active pellets having a low moisture content and at least about 95% active ingredient are described, as well as a method for manufacturing them. The active ingredient is selected from a class of N-hydrocarboyl phosphoroamidothioate and phosphoroamidodithioate compounds as described in the specification. The pellets generally have a moisture content of about 0.5% by weight or less, preferably less than about 0.3% by weight. The pellets can be produced by one of two types of processes as described in detail, including a high pressure axial extrusion process and a low pressure basket extrusion process.Type: GrantFiled: December 17, 1997Date of Patent: January 11, 2000Assignees: Valent U.S.A. Corporation, Tomen Agro, Inc.Inventors: Gary L. Cummings, Young-Jin Lee, James L. Platt, Jr., Matthew Hikade, Vernell Stornes
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Patent number: 5972349Abstract: Polyribosylribitol phosphate oligosaccharides are produced in a multistep process. The compound of the formula: ##STR1## wherein R.sub.1 is a first protecting group and R.sub.2 is a second protecting group, is coupled to a solid polyethylene glycol monomethyl ether (PEG) support. Following removal of the first protecting group, the resulting compound is coupled with a repeating unit for chain elongation of the formula: ##STR2## The protecting group is removed from the phosphorus atom and the steps of removing the first protecting group, coupling with the repeating unit is repeated until the desired number of repeating units in the oligomer has been terminated. The oligomer then is terminated with a chain terminating molecule of the formula: ##STR3## wherein m is an integer and R.sub.3 is a third protecting group.Type: GrantFiled: June 7, 1995Date of Patent: October 26, 1999Assignee: Connaught Laboratories LimitedInventors: Pele Chong, Ali Kandil, Charles Sia, Michel Klein
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Patent number: 5965708Abstract: Gluten protein-based biodegradable or edible films are produced using aqueous, essentially alcohol-free casting dispersions containing modified protein (preferably wheat gluten protein) and a plasticizer. The modified protein is prepared by treating purified naturally occurring wheat protein with a reducing agent (e.g., sodium metabisulfite) in order to reduce the average molecular weight of the wheat protein and to cleave disulfide bonds therein. Such modified wheat gluten protein lowers the viscosity and allows increased solid contents in the casting dispersions, allowing fabrication of improved films using continuous casting techniques and without use of organic solvents.Type: GrantFiled: March 11, 1997Date of Patent: October 12, 1999Assignee: Midwest Grain Products, Inc.Inventors: Sukh Bassi, Clodualdo C. Maningat, Rangaswamy Chinnaswamy, Li Nie, Michael K. Weibel, John J. Watson
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Patent number: 5958909Abstract: Derivatives of glucagon-like peptide I (GLP-1) and especially GLP-1(7-36) have been found to have insulinotropic activity. The invention pertains to the use of GLP-1(7-36) for the treatment of type II diabetes mellitus.Type: GrantFiled: November 20, 1996Date of Patent: September 28, 1999Assignee: The General Hospital CorporationInventor: Joel F. Habener
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Patent number: 5955453Abstract: Membrane-permeant phosphoinositides, including phosphatidylinositol phosphate esters, are described. A membrane-permeant phosphoinositide includes groups that neutralize the charges of the phosphate moieties of the phosphoinositide. A cell can be treated with the membrane-permeant phosphoinositide, which is then absorbed into the cell. The neutralizing groups can be removed intracellularly to afford the charged phosphoinositide.Type: GrantFiled: April 24, 1998Date of Patent: September 21, 1999Assignee: The Regents of the University of CaliforniaInventors: Roger Y. Tsien, Tao Jiang
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Patent number: 5914105Abstract: Novel fat-like petroleum based, water-free, insecticidal compositions are described which are particularly effective against insect pests such as cockroaches, ants, termites, flies, etc. The compositions may be used in various forms depending on the targeted pests. As an example, the composition in the form of a paste can be applied into cracks and crevices for control of such pests and have the advantage of superior durability and prolonged attractiveness.Type: GrantFiled: November 6, 1995Date of Patent: June 22, 1999Assignee: Ecolab Inc.Inventors: Stephen John Barcay, Douglas G. Anderson
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Patent number: 5906985Abstract: Pharmaceutical compounds of the formula ##STR1## in which n is 0, 1 or 2 and m is 1 or 2, R.sup.1 is hydrogen, C.sub.1-10 alkyl, C.sub.2-10 alkenyl, C.sub.2-10 alkynyl, phenyl, naphthyl, C.sub.1-10 alkyl-phenyl, C.sub.2-10 alkenyl-phenyl or C.sub.2-10 alkynyl-phenyl, said phenyl and naphthyl groups being optionally substituted, R.sup.2 is hydrogen or a protecting group, and Q is an acidic group; or a salt or ester thereof.Type: GrantFiled: August 21, 1997Date of Patent: May 25, 1999Assignees: Eli Lilly and Company Limited, Lilly, S.A.Inventors: Stephen Richard Baker, Almudena Rubio Esteban, John Goldsworthy, Concepcion Pedregal Tercero
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Patent number: 5900411Abstract: Use of forscarnet in the prophylaxis and/or treatment of Kaposi's sarcoma.Type: GrantFiled: August 15, 1996Date of Patent: May 4, 1999Assignee: Astra AkiebolagInventor: Linda Morfeldt
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Patent number: 5885572Abstract: The invention provides FabH polypeptides and DNA (RNA) encoding such FabH and a procedure for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing such FabH for the treatment of infection, particularly bacterial infections. Antagonists against such FabH and their use as a therapeutic to treat infections, particularly bacterial infections are also provided. Further provided are diagnostic assays for detecting diseases related to the presence of FabH nucleic acid sequences and the polypeptides in a host. Also provided are diagnostic assays for detecting polynucleotides encoding novel Fab family proteins and for detecting such polypeptides in a host.Type: GrantFiled: August 25, 1997Date of Patent: March 23, 1999Assignee: SmithKline Beecham CorporationInventors: Daniel Robert Gentry, John Timothy Lonsdale, David John Payne, Stewart Campbell Pearson
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Patent number: 5869469Abstract: Therapeutic compounds and methods for modulating amyloid deposition in a subject, whatever its clinical setting, are described. Amyloid deposition is modulated by the administration to a subject of an effective amount of a therapeutic compound comprising a phosphonate group and a carboxylate group, or a pharmaceutically acceptable salt or ester thereof. In preferred embodiments, an interaction between an amyloidogenic protein and a basement membrane constituent is modulated.Type: GrantFiled: August 18, 1997Date of Patent: February 9, 1999Assignee: Queen's University at KingstonInventors: Walter A. Szarek, Xianqi Kong
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Patent number: 5846955Abstract: This invention relates to a method for improving the efficiency of a drug containing a free carboxy group, the improvement comprising esterifying said carboxy group to the hydroxy group of the glycerol portion of a glycerolphospholipid ester having the formula: ##STR1## or pharmaceutically acceptable salts thereof wherein one of R.sub.1 and R.sub.2 is hydrogen and the other is hydrogen, a hydrocarbyl fatty acid acyl group having 4-26 carbon atoms or a hydrocarbyl heteroatom fatty acid acyl group having 3-25 carbon atoms, or ##STR2## and R is a naturally occurring polar head group characteristic of a glycerophospholipid isolated from endogenous sources;R.sub.3 is hydrogen or lower alkyl andR.sub.Type: GrantFiled: June 6, 1995Date of Patent: December 8, 1998Assignee: Research Corporation Technologies, Inc.Inventors: Charles Pidgeon, Robert J. Markovich
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Patent number: 5840917Abstract: A phosphorylamide derivative represented by the general formula (I): ##STR1## wherein R represents an amino group that may be substituted, or a salt thereof, possesses potent antibacterial activity against Helicobacter bacterium, especially Helicobacter pylori, and is useful for prevention or treatment of digestive diseases caused by Helicobacter bacterium, solely or in combination with an antacid or an acid secretion inhibitor.Type: GrantFiled: December 6, 1996Date of Patent: November 24, 1998Assignee: Takeda Chemical Industries, Ltd.Inventors: Satoru Oi, Hideaki Nagaya, Nobuhiro Inatomi, Masafumi Nakao, Hidefumi Yukimasa
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Patent number: 5824661Abstract: Compounds of the formula ##STR1## where m and n are integers 0 to 10 and m+n equals 0 to 10, (a) X is O or S(b) Z is a covalent bond; a monocyclic or polycyclic carbocycle ring moiety; or a monocyclic or polycyclic heterocyclic ring moiety containing one or more heteroatoms selected from O, S, or N;(c) Q is covalent bond; O; or S;(d) R is COOH, SO.sub.3 H, PO.sub.3 H.sub.2, or P(O)(OH)R.sup.4, wherein R.sup.4 is C.sub.1 -C.sub.8 alkyl;(e) R.sup.1, R.sup.2 and R.sup.5 are as defined in the claims.are useful in the treatment of calcium and phosphate elated disorders, such as arthritis and the like.Type: GrantFiled: September 7, 1994Date of Patent: October 20, 1998Assignee: The Procter & Gamble CompanyInventors: Marion David Francis, Susan Mary Kaas, Frank Hallock Ebetino
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Patent number: 5807846Abstract: The present invention is directed to compounds useful for the regulation of cholesterol of Formula I, methods for using them and pharmaceutical compositions thereof, ##STR1## wherein Ar and Ar.sup.1 are each independently selected from unsubstituted or substituted phenyl which substituents are from 1-5 in number and are each independently selected from alkyl, alkoxy, hydroxy, halogen, nitro, trifluoromethyl, COOH, and COOalkyl;X is --NH--, --O--, --S--, or --(CH.sub.2).sub.0-4 --, andR is hydrogen, alkyl, or phenyl.Type: GrantFiled: June 24, 1997Date of Patent: September 15, 1998Assignee: Warner-Lambert CompanyInventors: William Howard Roark, Bruce David Roth
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Patent number: 5807951Abstract: The present invention provides silicate polymers which regulate the function of a living body by restoring and normalizing the lowered cell functions due to diseases. The silicate polymers are preferably water soluble. The molecular weight of the polymers is in the range of 4,800 to 2,000,000, preferably 20,000 to 1,000,000, and they have a degree of polymerization in the range of 75 to 33,000, preferably 490 to 16,500. The monomer unit is --(SiO.sub.2)--. The polymers may be produced by dissolving a water-soluble silicate or a silicic acid containing material such as water glass in water to obtain an aqueous solution. The solution may be admixed with an acid to adjust the pH to 2-10, preferably 4-9.5. A saccharide or sugar alcohol or pharmaceutically acceptable salt may also be admixed with the solution. The aqueous solution is preferably dried to obtain a powder by heating at 150.degree. C. to 250.degree. C. or by lyophilization.Type: GrantFiled: April 30, 1997Date of Patent: September 15, 1998Assignee: Nippon Zoki Pharmaceutical Co., Ltd.Inventors: Jin-emon Konishi, Giichi Hamada
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Patent number: 5770587Abstract: There are disclosed novel compounds having the formula ##STR1## which exhibit antifungal activity.Type: GrantFiled: October 21, 1996Date of Patent: June 23, 1998Assignee: Merck & Co., Inc.Inventors: Angela Basilio, Fernando Pelaez, Maria Teresa Diez, Francisca Vicente, Sandra A. Morris, James E. Curotto, Gerald F. Bills, Sarah J. Dreikorn, Otto D. Hensens, Jerrold M. Liesch, Rosalind G. Jenkins, John R. Thompson
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Patent number: 5712261Abstract: A method is provided for preventing and/or treating hypertriglyceridemia, and/or atherosclerosis and/or pancreatitis resulting from hypertriglyceridemia, employing a squalene synthetase inhibitor.Type: GrantFiled: June 21, 1995Date of Patent: January 27, 1998Inventors: David R. Magnin, Scott A. Biller, John K. Dickson, Jr., R. Michael Lawrence, Richard B. Sulsky
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Patent number: 5709890Abstract: An insecticide composition is enhanced from the standpoint of its ability to be absorbed by insects, such as red fire ants, particularly dithiophosphate ester pesticides by the addition of a small amount of a water soluble non-aromatic polyorganic acid or salt form thereof such as polyaspartic acid, particularly preferred with a molecular weight in the range of about 3000 to 40,000.Type: GrantFiled: March 20, 1997Date of Patent: January 20, 1998Assignee: Donlar CorporationInventor: J. Larry Sanders
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Patent number: 5698541Abstract: The invention concerns compounds of the general formula I ##STR1## in which R denotes a lower alkyl which can be substituted if desired by hydroxy, alkoxy, amino, dialkylamino, alkylmercapto, alkylsulfinyl, alkanesulfonyl, cycloalkyl, aryl or a heterocyclic ring, or it denotes lower alkenyl, cycloalkyl, cycloalkenyl, aryl or a heterocyclic ring andR.sub.1 and R.sub.2 can be, independently of one another, hydrogen, lower alkyl, cycloalkyl, aryl or arylmethyl,their optically active salts as well as their pharmacologically acceptable salts, processes for their production as well as pharmaceutical agents which contain these compounds for treating diseases of calcium metabolism. Moreover the invention concerns compounds of formula II as intermediate products for the production of compounds of formula I.Type: GrantFiled: September 25, 1996Date of Patent: December 16, 1997Assignee: Boehringer Mannheim GmbHInventors: Gerd Zimmermann, Angelika Esswein, Christos Tsaklakidis, Frieder Bauss
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Patent number: 5698540Abstract: A liquid pesticidal composition including Acephate and one or more N-alkyl-2-pyrrolidones, and methods for stabilizing and inhibiting decomposition of Acephate by adding one or more N-alkyl-2-pyrrolidones to Acephate. The storage stability of Acephate bulk or Acephate in an Acephate-containing liquid pesticidal composition is improved by addition of the N-alkyl-2-pyrrolidone(s).Type: GrantFiled: February 10, 1995Date of Patent: December 16, 1997Assignee: Sumitomo Chemical Company, LimitedInventors: Yasuyuki Katayama, Toshiro Ohtsubo
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Patent number: 5686428Abstract: Combinations of 3'-azido-3'deoxythymidine and phsphonoformate have been found to produce a synergistic inhibitory effect against human immunodeficiency virus (HIV).Type: GrantFiled: February 4, 1994Date of Patent: November 11, 1997Assignee: Aktiebolaget AstraInventors: Bertil F. H. Eriksson, Raymond F. Schinazi
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Patent number: 5679828Abstract: Some betulinic acid and dihydrobetulinic acid acyl derivatives according to the present invention have been found to have potent anti-HIV activity. Introducing a C.sub.2 -C.sub.20 substituted or unsubstituted acyl group at the C.sub.3 -hydroxy group of betulinic acid and dihydrobetulinic acid produces the corresponding 3-O-acyl derivatives. The compounds of the present invention have the following formulae: ##STR1## where R may be a mono- or dicarboxylacyl group, substituted or unsubstituted, of from about 2 to about 20 carbon atoms, and R' may be hydrogen or a C.sub.2 -C.sub.10 substituted and unsubstituted alkyl or aryl group.Type: GrantFiled: June 5, 1995Date of Patent: October 21, 1997Assignees: Biotech Research Labs, Inc., University of North Carolina at Chapel HillInventors: Kuo-Hsiung Lee, Yoshiki Kashiwada, Fumio Hashimoto, Louis Mark Cosentino, Mark Manak
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Patent number: 5658897Abstract: The present invention relates to cyclopentane (or cyclopentane) heptanoic or cyclopentane (or cyclopentene) heptenoic acid, 2-hydrocarbyl phosphinyloxyalkyl or phosphonamidoalkyl, 1-esters, and derivatives thereof, useful as therapeutic agents. In particular, the therapeutic agents of this invention are useful as ocular hypotensives.Type: GrantFiled: April 8, 1996Date of Patent: August 19, 1997Assignee: AllerganInventor: Robert M. Burk
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Patent number: 5653973Abstract: Baits useful for controlling lepidoptera populations is made with (a) a diet component for lepidoptera; (b) a toxicant; (c) a chemiluminescent, visual attractant and (d) an encapsulating agent that will allow moisture to permeate and form an external condensate of said diet and said toxicant. The diet, toxicant, and chemiluminescent visual attractant can be used in the same bait particle in a homogeneous or layered structure. Alternatively, the diet/toxicant may be used with a first encapsulating agent in a first bait particle with the chemiluminescent, visual attractant encapsulated in a second bait particle and distributed among the diet/toxicant bait particles.Type: GrantFiled: August 16, 1996Date of Patent: August 5, 1997Assignee: Micro Flo CompanyInventors: Chel W. Lew, Keith Branly, Jesse Gaytan, Osborn Jones Turner
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Patent number: 5646133Abstract: An insecticide composition is enhanced from the standpoint of its ability to be absorbed by insects, such as red fire ants, particularly dithiophosphate ester pesticides by the addition of a small amount of a water soluble non-aromatic polyorganic acid or salt form thereof such as polyaspartic acid, particularly preferred with a molecular weight in the range of about 3000 to 40,000.Type: GrantFiled: March 14, 1996Date of Patent: July 8, 1997Assignee: Donlar CorporationInventor: J. Larry Sanders
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Patent number: 5631246Abstract: The use of platelet-activating factor (PAF) to increase the levels of von Willebrand factor and/or Factor VIII in blood is disclosed. The use of PAF has particular application in the treatment of von Willebrand disease and haemophilia A.Type: GrantFiled: March 15, 1993Date of Patent: May 20, 1997Assignee: The Canadian Red Cross SocietyInventors: Sofia Hashemi, Douglas Palmer
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Patent number: 5627173Abstract: Phosphonoacetic acid derivatives and their use for treating degenerative joint disorders Compounds of the formula I ##STR1## are suitable for producing pharmaceuticals for the treatment and prophylaxis of degenerative joint disorders, of rheumatic disorders accompanied by cartilage breakdown, such as rheumatoid arthritis, joint trauma and chondrolysis as a consequence of prolonged immobilization of the joint, of inflammations, septic shock, disorders with impaired leukocyte adhesion, disorders caused by an elevated concentration of tumor necrosis factor alpha, such as cachexia or Crohn's disease.Type: GrantFiled: January 23, 1996Date of Patent: May 6, 1997Assignee: Hoechst AktiengesellschaftInventors: Rolf Graeve, Werner Thorwart, Ruth Raiss, Klaus U. Weithmann, Stefan M ullner
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Patent number: 5627172Abstract: A method is disclosed for lowering the concentration of a serum lipid or lipoprotein component in a mammal, including the step of administering to a mammal in need of such treatment a hypolipidemic, therapeutically effective amount of at least one creatine derivative.Type: GrantFiled: March 4, 1994Date of Patent: May 6, 1997Assignee: Natural Supplement Association, IncorporatedInventors: Anthony Almada, Edward Byrd