Abstract: 4,4′-diaminodiphenylsulphone is a bactericide and anti-inflammatory agent. It is known to have therapeutic activity against leprosy, dermatitis herpetiformis, actinomycotic mycetoma, asthma, malaria, rheumatoid arthritis, Kaposiis sarcoma, pneumocystis carinii (pneumonia), subcorneal pustular dermatosis and cystic acne, in patients in need of such therapy. It is also known to have therapeutic activity against memory loss in patients in need of such therapy, including patients suffering from Alzheimer disease and related neurodegenerative disorders. Donepezil hydrochloride (donepezil) is an acetylcholinesterase inhibitor that is currently used for the symptomatic treatment of Alzheimer disease in patients in need of such therapy. It has now been found that combinations of 4,4′-diaminodiphenylsulphone and cholinesterase inhibitors unexpectedly show synergistic effects in the prevention and/or treatment of dementia.

Abstract: Synergistic fungicidal composition comprising a compound analogous to strobilurin of formula (I): in which: A is the nitrogen atom or the —CH group, B is the —OCH2— or —CH2O— or CH(CH3)—O—N═CH— or —CH═N—O—CH(CH3)— group or the group R1 is an alkyl group containing 1 to 4 carbon atoms, R2 is —OCH3 or —NHCH3, X is a halogen atom, the cyano group or an alkyl or haloalkyl group containing 1 to 4 carbon atoms, n is equal to 1 or 2, with, when n is equal to 2, the possibility of having different X groups, and at least one fungicidal compound B, and a process for the curative or preventive control of phytopathogenic fungi using the composition.

Abstract: The invention relates to use of (a) compounds of phosphorus containing at least partly lipophilic organic radicals together with (b) urea and/or urea derivatives in selected quantity ratios of (a) to (b) as a soil additive for biologically controlling plant-parasitic soil nematodes by strengthening the correspondingly antagonistic soil potential, more particularly by strengthening the growth of antagonistic and/or nematicidal rhizosphere bacteria and/or corresponding mycorrhiza strains—and at the same time strengthening the growth of cultivated plants in soil. The multicomponent mixtures which strengthen bacterial growth are preferably introduced into the region of the plant roots in the form of an aqueous preparation using plant-compatible emulsifiers before and/or during plant growth. Components (a) and (b) are used in such quantity ratios that the ratio by weight of C to N is no higher than 6:1 and preferably no higher than 5:1.

Abstract: Novel non-steroidal ligands for the estrogen receptor which possess tissue-dependent estrogenic and antiestrogenic activity as well as methods for making the same and their applications in treating a variety of disease states.

Abstract: The present invention relates to derivatives of 1-hydroxymethylene-1,1-bisphosphonic acid, the pharmaceutical compositions comprising them, and their application in therapeutics, particularly for the treatment of cancerous tumors. It is also directed to a methods of preparation of such derivatives.

Abstract: The present invention relates to pharmaceutical compositions and methods for treating a retinal disorder or glaucoma using NAALADase inhibitors.

Abstract: The invention concerns compounds derived from (&agr;-aminophosphino) peptides, of general formula (I), in which R1 and R2 each represents a hydrogen atom or taken together form an imine with the adjacent nitrogen atom; R3 represents an alkyl group, an alkenyl group, a phenyl group, a benzyl group, all these groups capable of being substituted or not, a hydrogen atom, a cycloalkyl group, a cycloalkylmethyl group or finally, a methyl group substituted by a heterocyclic, aromatic or saturated group; R4 represents a phenyl group, a benzyl group, these groups capable of being substituted or not, a hydrogen atom, an alkyl group, analkenyl group or a cycloalkyl group; R5 represents an alkyl group, an alkenyl group, a phenyl group, a benzyl group, all these groups capable of being substituted or not, a hydrogen atom, a cycloalkyl, cycloalkylmethyl group or finally a methyl group substituted by a heterocyclic, aromatic or saturated group; R6, R7 and R8 can in particular represent a hydrogen atom, an alkyl group, a phe

Abstract: Therapeutic compounds and methods for modulating amyloid deposition in a subject, whatever its clinical setting, are described. Amyloid deposition is modulated by the administration to a subject of an effective amount of a therapeutic compound comprising a phosphonate group and a carboxylate group, a congener thereof, or a pharmaceutically acceptable salt or ester thereof. In preferred embodiments, an interaction between an amyloidogenic protein and a basement membrane constituent is modulated.

Abstract: The present invention provides a method of treating ocular hypertension or glaucoma which comprises administering to an animal having ocular hypertension or glaucoma therapeutically effective amount of a compound represented by the general formula I; 1

Abstract: Bis-(N,N′-bis-(2-haloethyl)amino)phosphoramidates, pharmaceutical compositions containing them, methods of treatment using them, and processes for their preparation. The compounds possess anti-tumor activities or are capable of being modified to have anti-tumor activities; and this invention relates to the use of the compounds in methods for the treatment of tumors and, especially, for the treatment of cancer.

Abstract: The invention encompasses the novel class of compounds represented by the formula below, which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases, including diabetes.

Abstract: The invention relates to the identification of farnesyl-protein transferase (FPT) as a gene that is upregulated in systemic lupus erythematosus (SLE). Given the widespread availability of inhibitors of FPT, the inventors propose to treat the symptoms of SLE using such inhibitors.

Abstract: A fungicidal composition comprising a compound A having the formula: 1

Abstract: The invention concerns a synergetic fungicide and/or bactericide composition comprising famoxadone and a phosphorous acid derivative; and a method for fighting, for cure or prevention, against phytopathogenic fungi and/or bacteria using such a composition.

Abstract: The invention encompasses the novel class of compounds represented by the formula below, which are inhibitors of the PTP-1B enzyme.

Abstract: The present invention is a method and composition to increase bone strength in a manner that decreases fracture incidence, which may or may not include increasing bone mineral density (“BMD”). The invention includes administering an effective amount of a bisphosphonate to a host in need thereof to increase bone strength, which inhibits the apoptosis of osteoblasts and osteocytes, without a significant effect on osteoclasts. In one embodiment, the bisphosphonate is not 1-amino-3-(N,N-dimethylamino)-propyliden-1,1-bisphosphonic acid or its pharmaceutically acceptable salt. An increase in osteoblast life span can lead to an increase in bone mass, i.e., an anabolic effect. Preservation of osteocyte life span can increase bone strength, which may be disproportional to the increase in bone mass.

Abstract: Fluquinconazole can be used to combat wood damaging fungi.

Abstract: Butters are made from high oleic vegetable oils during a procedure by which a large percentage of the oleic acid is transformed into trans-configured elaidic acid, without significantly increasing the saturated fat present in the high oleic vegetable oil. The vegetable oils have an initial oleic acid content of at least about 75 weight percent, with the hard butter made from it being a high elaidic hard fat having at least about 65% trans-configured elaidic acid. The preferred process is a single-step procedure of hydrogenation in the presence of a deadened catalyst such as a sulfur-poisoned nickel catalyst.

Abstract: Applicant has probed the Edg2 lysophosphatidic acid (LPA) receptor with a series of LPA analogs to determine receptor activation. The present invention is drawn to a series of LPA analogs which function as Edg2 receptor agonists, and methods of using such compounds to activate the Edg2 receptor of the surface of a cell. The compounds of the invention comprise a glycerol backbone with an Sn1 ester-linked saturated or unsaturated alkyl group, substitutions of the hydroxyl group (—OH) at carbon two of the glycerol backbone, and optional replacement of the phosphate di-anion with either a hydroxyl group or a dimethylated phosphate. These LPA analogs may find uses in cancer and neurological disorders.

Abstract: A fungicidal composition for plants containing phosphonate (PO3) and phosphate (PO4) salts, and derivatives thereof is disclosed. The composition provides a single product which may be employed to control a Phytophthora infestans infection in plants.

Abstract: The present invention relates to the use of pharmaceutically acceptable cholinesterase inhibitors for the preparation of a pharmaceutical composition for the treatment or prophylaxis of arthritic disorders, including osteoarthritis, rheumatoid arthritis and other rheumatoid diseases such as Juvenile Arthritis, Systemic Lupus Erythematosis, Sjogren's Syndrome, Progressive Systemic Sclerosis, Polymyositis, Dermatomyositis, Ankylosing Spondilitis, Reiter's Syndrome, Psoriatic Arthritis, Relapsing Polychondritis, Relapsing Panniculitis, Crohn's Disease, Ulcerative Colitis, Heredity Complement Deficiencies, Collagen Vascular Diseases, Felty's Syndrome, rheumatological manifestations associated with bacterial and viral endocarditis or myocarditis and other rheumatological manifestations such as anaemia of chronic disorders. The invention also relates to a novel method of treatment or prophylaxis of such diseases and manifestations.

Abstract: Synergistic fungicidal composition comprising propamocarb and a derivative of phosphorous acid; and process for the curative or preventative control of phytopathogenic fungi by use of such a composition.

Abstract: The present invention relates to methods of treating psoriasis by inhibiting one or more matrix metalloproteinase enzymes (“MMPs”). It is based, at least in part, on the discovery that the expression patterns of certain MMPs and related molecules are altered in patients suffering from psoriasis, relative to normal subjects. Certain expression patterns are altered even in unaffected skin of psoriasis-afflicted patients, although aberrancies are more pronounced in psoriatic lesions. In various non-limiting embodiments, the present invention provides for methods of treating psoriasis, including preventing the development of new psoriatic lesions, comprising administering, to subjects in need of such treatment, effective concentrations of compounds which inhibit the enzymatic activity of one or more MMP. Suitable inhibitors include tetracycline and its derivatives and various hydroxymate, carboxylic acid, and phosphonic acid derivatives.

Abstract: A fungicidal composition for plants containing phosphonate (PO3) and phosphate (PO4) salts, and derivatives thereof is disclosed. The composition provides a single product which may be employed to control a Phytophthora infestans infection in plants.

Abstract: Synergistic fungicidal composition comprising a compound analogous to strobilurin of formula (I): 1

Abstract: A compound of the following formula: and the salts thereof, wherein A is hydrogen, halo, or hydroxy; the broken line represents an optional double bond with proviso that if the broken line is a double bond, then A is absent; Ar1 is optionally substituted phenyl; Ar2 is aryl or heteroaryl selected from phenyl, napththyl, or pyridyl, the aryl or heteroaryl being optionally substituted; R1 is hydrogen, hydroxy, or C1-C4 alkyl; and R2 and R3 are independently selected from optionally substituted C1-C7 alkyl, C3-C6 cycloalkyl, C2-C6 alkenyl, C2-C6 alkynyl, or R2 and R3, together with the nitrogen atom to which they are attached, form an optionally substituted pyrrolidine, piperidine or morpholine ring. These compounds are useful as kappa agonists.

Abstract: A compound of the following formula: and the salts thereof, wherein A is hydrogen, halo, hydroxy, or the like; the broken line represents an optional double bond with proviso that if the broken line is a double bond, then A is absent; Ar1 is optionally substituted phenyl or the like; Ar2 is aryl or heteroaryl selected from phenyl, napththyl, pyridyl, and the like, the aryl or heteroaryl being optionally substituted; R1 is hydrogen, hydroxy, C1-C4 alkyl, or the like; and R2 and R3 are independently selected from optionally substituted C1-C7 alkyl, C3-C6 cycloalkyl, C2-C6 alkenyl, C2-C6 alkynyl, and the like or R2 and R3, together with the nitrogen atom to which they are attached, form an optionally substituted pyrrolidine, piperidine or morpholine ring. These compounds are useful as kappa agonists.

Abstract: Method for improving the fruit yields from banana plants, characterized in that an effective and non-phytotoxic dose of a compound A, chosen from:

Abstract: A fungicidal mixture, comprising a) a carbamate of the formula I,  where T is CH or N, n is 0, 1 or 2 and R is halogen, C1-C4-alkyl or C1-C4-haloalkyl, and where the radicals R may be different if n is 2, and b) an active compund of the formula II, where: Y is hydrogen, a metal atom of the 1st to 3rd main group of the Periodic Table of the Elements or a group NR3R4R5R6; R2 is hydrogen, a C1-C18-alkyl group which may be substituted by halogen or a nitro group, a C2-C8-alkenyl or C2-C8-alkinyl group which may be substituted by halogen or a nitro group, a C1-C8-alkoxy-C1-C8-alkyl or a C2-C8-alkenyl-C1-C8-alkyl group, an unsubstituted or substituted aryl group having 6 to 14 carbons, a C3-C7-cycloalkyl group, a C1-C4-alkylaryl group or a heterocyclic group having 5 or 6 ring atoms and a hetero atom from the group consisting of N, O and S, where the heterocyclic group is attached directly or via an aliphatic chain to the oxygen atom, and R3-R6 independently of one anot

Abstract: Method for improving the fruit yields from banana plants, characterized in that an effective and non-phytotoxic dose of a compound A, chosen from:

Abstract: A low volatile organic compound co-solvent system is disclosed for preparing emulsion concentrates of low melting organophosphorous insecticides wherein the bioefficacy of the insecticide active is significantly enhanced. The co-solvent system comprises a water-soluble ethoxylated fatty acid/rosin acid-nonionic surfactant composition.

Abstract: Synergistic fungicidal composition comprising a compound analogous to strobilurin of formula (I): ##STR1## in which: A is the nitrogen atom or the --CH group,B is the --OCH.sub.2 -- or --CH.sub.2 O-- or CH(CH.sub.3)--O--N.dbd.CH-- or --CH.dbd.N--O--CH(CH.sub.3)-- group or the group ##STR2## R.sub.1 is an alkyl group containing 1 to 4 carbon atoms, R.sub.2 is --OCH.sub.3 or --NHCH.sub.3,X is a halogen atom, the cyano group or an alkyl or haloalkyl group containing 1 to 4 carbon atoms,n is equal to 1 or 2, with, when n is equal to 2, the possibility of having different X groups,and at least one fungicidal compound B, anda process for the curative or preventive control of phytopathogenic fungi using the composition.

Abstract: The present invention provides compounds that inhibit the association of platelet-derived growth factor and phosphatidylinositol 3-kinase. The present invention also provides pharmaceutical compositions that contain a compound that inhibits the association of platelet-derived growth factor and phosphatidylinosital 3-kinase, and methods of treating cancer, restenosis, arthritis, dermatitis, atherosclerosis, vein graft intimal hyperplasia, neointimal hyperplasia of vascular smooth muscle and psoriasis using compounds that inhibit the association of platelet-derived growth factor and phosphatidylinositol 3-kinase.

Abstract: Disclosed is a polycarbonate resin composition comprising an aromatic polycarbonate (PC), a high-impact polystyrene resin (HIPS) and a non-halogen phosphate, and also talc and/or polytetrafluoroethylene (PTFE). Optionally, the composition may contain a core/shell-type, grafted, rubber-like elastic material. The composition has good flame retardancy and has good physical properties such as stiffness, impact resistance, outward appearance and flowability.

Abstract: An improved fungicidal composition is a mixture of (a) fungicide used to combat phytopathogenic fungi and (b) at least one phosphonate or phosphinate of formula R.sup.1 R.sup.2 P(O)OR.sup.3 where R.sup.1 is C.sub.6-20 alkyl, C.sub.6-20 alkoxy or optionally substituted phenyl, R.sup.2 is benzyl, C.sub.6-20 alkyl optionally interrupted by NH or O, di-C.sub.6-20 alkylamino or the group --CH.sub.2 CH.sub.2 --R.sup.1 P(O)OR.sup.3, and R.sup.3 C.sub.6-20 alkyl. Some of the compounds of formula (I) are novel.

Abstract: Compounds of the formula ##STR1## wherein X in each of formulas (1) and (2) represents a substituted or unsubstituted alkylene, alkenylene, or alkynylene linker of 2-6 C;Y represents one or more carbocyclic or heterocyclic rings; when two or more rings are present in Y, they may optionally be fused; andR' represents a cation, H or a substituted or unsubstituted alkyl group of 1-6 C; andthe dotted lines represent optional .pi.-bonds,promote bone formation and are thus useful in treating osteoporosis, bone fracture or deficiency, primary or secondary hyperparathyroidism, periodontal disease or defect, metastatic bone disease, osteolytic bone disease, post-plastic surgery, post-prosthetic joint surgery, and post-dental implantation. These compounds can be used in combination with other bone growth-promoting compounds and/or estrogens and/or bisphosphonates for this purpose.

Abstract: A method for the protection of trees of the families Musaceae or Plantanginaceae from destructive pests whereby the trees to be protected share a common root system.

Abstract: This invention relates to a method for treating snoring, sleep apnea and other form of sleep-disordered breathing, which comprises administration of a therapeutically effective dose of an acetyl choline esterase inhibitor (CEI) such as pyridostigmine or a pharmaceutically acceptable salt thereof.

Abstract: Synergistic fungicidal composition comprising a compound analogous to strobilurin of formula (I): ##STR1## in which: A is the nitrogen atom or the --CH group,B is the --OCH.sub.2 -- or --CH.sub.2 O-- or CH(CH.sub.3)--O--N.dbd.CH-- or --CH.dbd.N--O--CH(CH.sub.3)-- group or the group ##STR2## R.sub.1 is an alkyl group containing 1 to 4 carbon atoms, R.sub.2 is --OCH.sub.3 or --NHCH.sub.3,X is a halogen atom, the cyano group or an alkyl or haloalkyl group containing 1 to 4 carbon atoms,n is equal to 1 or 2, with, when n is equal to 2, the possibility of having different X groups,and at least one fungicidal compound B, anda process for the curative or preventive control of phytopathogenic fungi using the composition.

Abstract: This invention relates to the use of stroid sulphate sulphatase inhibitors which prevent the normal physiological effect of DHEA or related steroids on inflammatory responses.

Abstract: The present invention relates to fungicidal compositions and their use as a method for controlling phytopathogenic fungi comprising the application of a selected fungicidally active N-acetonylbenzamide compound and a second fungicidally active compound selected from the group consisting of an inhibitor of respiration at cytochrome complex III, ziram, fluazinam, zarilamide, chlorothalonil, propamocarb, folpet, fosetyl-aluminum or a fungitoxic metabolite thereof, a triphenyltin type fungicide and a copper containing fungicide to plant seed, to plant foliage or to a plant growth medium. The compositions and method of use provide higher fungicidal activity than separate use of the same compounds.

Abstract: There is disclosed a microbicidal composition comprising as active ingredients:(I) a dithiocarbonimide compound represented by the general formula: ##STR1## wherein Z represents CH group or nitrogen atom, R.sup.1 and R.sup.2 are the same or different and represent hydrogen atom, C.sub.1 -C.sub.6 alkyl group, halogen atom, C.sub.1 -C.sub.6 alkoxy group, C.sub.1 -C.sub.6 haloalkyl group or C.sub.1 -C.sub.6 haloalkoxy group, or R.sup.1 and R.sup.2 are taken together to form methylenedioxy group optionally substituted with fluorine atom, and(II) at least one compound selected from the group consisting of ethylenebis (dithiocarbamate) compound, copper compound, phthalimide microbicidal compound, chlorothalonil, anilide microbicidal compound, cymoxanil, dimethomorph and fosetyl.

Abstract: A fertilizer composition for plants containing phosphonate and phosphate slats, and derivatives thereof is disclosed. The composition provides a single product which may be employed to stimulate the growth response in plants.

Abstract: Use of 1-amino-3-N,N-dimethylamino)-propyliden-1,1-bisphosphonic acid of the structural formula: ##STR1## or of its monosodium or other pharmaceutically acceptable salt, as a biological carrier for bone active substances or for the preparation of a medicament for the diagnosis, prophylaxis and/or treatment of bone and/or mineral metabolism disorders.

Abstract: Method for improving the fruit yields from banana plants, characterized in that an effective and non-phytotoxic dose of a compound A, chosen from:salts of a monoalkyl phosphonate and of a mono-, di- or trivalent metal cation, such as fosetyl-Al, orphosphorous acid and its alkali metal or alkaline-earth metal salts,is applied on the banana plants.

Abstract: This application discloses a method of treating or preventing atrial arrhythmias which utilizes compounds which are blockers of the ultra-rapidly-activating delayed rectifier K.sup.+ current (I.sub.Kur) of the human atrium in a use-dependent and/or rate dependent manner, and which provide the selective block preferentially at fast heart rates so that the effect is realized or maximized when required.

Abstract: Compounds having anti-inflammatory and other activities are disclosed. The compounds are derived from phorboids of the diterpene- and benzolactam-classes.

Abstract: Methods and compositions for inhibiting fouling in vinyl monomers are disclosed. Alkylphosphonate esters or acids thereof are added to vinyl monomers, particularly ethylene dichloride, that are undergoing processing to inhibit fouling.

Abstract: A fungicidal composition for plants containing phosphonate and phosphate salts, and derivatives thereof is disclosed. The composition provides a single product which may be employed to control a parasitic fungi in plants through mitigation of pathological acerbation of certain fungi.

Abstract: A fungicidal composition comprising a compound A having the formula: ##STR1## wherein M is an oxygen or sulphur atom, n is 0 or 1, and Y is a fluorine or chlorine atom or a methyl radical; and at least one fungicidal compound B. A method for preventing or controlling phytopathogenic fungi on crops by applying an effective and non-plant-poisonous amount of said compound on the exposed parts of the plants is also disclosed.