Triester Patents (Class 514/144)
  • Patent number: 11249247
    Abstract: The present invention, as disclosed and described herein, in one aspect thereof comprises a preform for making a vortex optical fiber includes a glass cylinder formed substantially of silicone dioxide that defines a core portion along a longitudinal axis of the glass cylinder and a cladding portion surrounding the core portion. The glass cylinder further defines a plurality of holes running parallel to the longitudinal axis from a first end of the glass cylinder to a second end of the glass cylinder.
    Type: Grant
    Filed: January 25, 2019
    Date of Patent: February 15, 2022
    Assignee: NXGEN PARTNERS IP, LLC
    Inventor: Solyman Ashrafi
  • Patent number: 9962353
    Abstract: The present invention relates to use of a tall oil fatty acid and/or a tall oil fatty acid which is modified by saponification in binding toxins.
    Type: Grant
    Filed: October 16, 2014
    Date of Patent: May 8, 2018
    Assignee: Hankkija Oy
    Inventor: Juhani Vuorenmaa
  • Publication number: 20150033418
    Abstract: A first aspect of the invention is an agricultural composition comprising nanoparticles, an agrochemical active ingredient in the nanoparticles, and optionally (but in some embodiments preferably) a carrier for the nanoparticles. In some embodiments, the nanoparticles are viral particles or capsids, particularly plant viral particles or capsids. In some embodiments, the carrier comprises an inert or biodegradable carrier (e.g., a solid carrier) to which the nanoparticles are bound or in which the nanoparticles are suspended. In some embodiments, the carrier comprises inert or biodegradable polymer fibers.
    Type: Application
    Filed: April 16, 2013
    Publication date: January 29, 2015
    Inventors: Steven A. Lommel, Julie Willoughby, Richard Guenther
  • Publication number: 20140336137
    Abstract: The invention relates to nitroso derivatives including carboxylic acid and phosphoric acid esters of hydroxy nitroso compounds that donate nitroxyl (HNO) under physiological conditions. The compounds and compositions of the invention are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure, ischemia/reperfusion injury and cancer.
    Type: Application
    Filed: July 28, 2014
    Publication date: November 13, 2014
    Inventors: Lisa Marie Frost, Stephen Martin Courtney, Frederick Arthur Brookfield, Vincent Jacob Kalish
  • Publication number: 20140162874
    Abstract: This document discloses molecules having the following formula (“Formula One”): and processes related thereto.
    Type: Application
    Filed: February 12, 2014
    Publication date: June 12, 2014
    Applicant: DOW AGROSCIENCES LLC
    Inventors: Maurice C. Yap, Ann M. Buysse, Daniel Knueppel, Yu Zhang, Negar Garizi, Noormohamed M. Niyaz, Christian T. Lowe, Ricky Hunter, Tony K. Trullinger, David A. Demeter, Dan Pernich, Carl DeAmicis, Ronald Ross, JR., Timothy C. Johnson
  • Patent number: 8703748
    Abstract: The present invention relates to a cleaning composition for removing cellular components from tissue for transplantation derived from humans and animals. More particularly, the present invention relates to a cleaning composition for treating tissue for transplantation comprising a polyoxyethyleneglycol C14-C20alkyl ether as a first protein solubilizing component, a C6-C8alkylphenol polyethoxylate as a first lipid solubilizing component, a C10-C16alkyl glycoside as a second protein solubilizing component and a C9-C12alkylphenoxy polyethoxy ethanol as a second lipid solubilizing component.
    Type: Grant
    Filed: February 10, 2010
    Date of Patent: April 22, 2014
    Assignee: CG BIO Co., Ltd.
    Inventors: Byoung Suck Kim, Seok Beom Song, Goo Won Jeong, Hyo Jung Kang, Jae Deuck Jung
  • Publication number: 20140013654
    Abstract: Ready-to-use foamable pesticide compositions that contain a particulate pesticide suspended therein and applicators for dispensing such compositions. Methods for treating pests such as arthropods by contacting pests with such compositions are also provided.
    Type: Application
    Filed: September 17, 2013
    Publication date: January 16, 2014
    Inventor: Terrence R. Burke
  • Publication number: 20140005049
    Abstract: The invention relates to active compound combinations, in particular within a composition, which comprises (A) an amidine compound of formula (I) and a further fungicidally (B-1), insecticidally (B-2) active or plant growth regulating compound (B-3). Moreover, the invention relates to a method for curatively or preventively controlling the phytopathogenic fungi of plants or reducing the mycotoxin contamination of plant or plant parts, to the use of a combination according to the invention for the treatment of seed, to a method for protecting a seed and not at least to the treated seed.
    Type: Application
    Filed: September 6, 2013
    Publication date: January 2, 2014
    Inventors: Kerstin ILG, Ulrich Heinemann, Peter Dahmen, Ulrike Wachendorff-Neumann
  • Patent number: 8486920
    Abstract: The present invention provides a composition for controlling plant diseases comprising, as active ingredients, ethaboxam and tolclofos-methyl.
    Type: Grant
    Filed: November 20, 2009
    Date of Patent: July 16, 2013
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: Makoto Kurahashi, Yuichi Matsuzaki
  • Publication number: 20120316139
    Abstract: Compounds of the general formula are disclosed with activity towards treating diseases related to inflammation, such as cancer, neurodegenerative and cardiovascular diseases. Pharmaceutical compositions and methods of use are also disclosed.
    Type: Application
    Filed: July 27, 2012
    Publication date: December 13, 2012
    Inventor: Basil RIGAS
  • Patent number: 8318705
    Abstract: The invention relates to nitroso derivatives including carboxylic acid and phosphoric acid esters of hydroxy nitroso compounds that donate nitroxyl (HNO) under physiological conditions. The compounds and compositions of the invention are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure, ischemia/reperfusion injury and cancer.
    Type: Grant
    Filed: May 7, 2009
    Date of Patent: November 27, 2012
    Assignee: Cardioxyl Pharmaceuticals, Inc.
    Inventors: Lisa M. Frost, Stephen M. Courtney, Frederick A. Brookfield, Vincent J. Kalish
  • Publication number: 20110312917
    Abstract: The present invention relates to a cleaning composition for removing cellular components from tissue for transplantation derived from humans and animals. More particularly, the present invention relates to a cleaning composition for treating tissue for transplantation comprising a polyoxyethyleneglycol C14-C20alkyl ether as a first protein solubilizing component, a C6-C8alkylphenol polyethoxylate as a first lipid solubilizing component, a C10-C16alkyl glycoside as a second protein solubilizing component and a C9-C12 alkylphenoxy polyethoxy ethanol as a second lipid solubilizing component.
    Type: Application
    Filed: February 10, 2010
    Publication date: December 22, 2011
    Applicant: CG BIO CO., LTD.
    Inventors: Byoung Suck Kim, Seok Beom Song, Goo Won Jeong, Hyo Jung Kang, Jae Deuck Jung
  • Publication number: 20110281816
    Abstract: The invention relates to novel fungicidally active compound combinations of 2?-cyano-3,4-dichloroisothiazole-5-carboxanilide of the formula and active compounds listed in the disclosure.
    Type: Application
    Filed: May 13, 2010
    Publication date: November 17, 2011
    Inventors: Peter Dahmen, Ulrike Wachendorff-Neumann, Rolf Pontzen, Lutz Assmann, Haruko Sawada
  • Patent number: 7973083
    Abstract: A pesticidally active combination comprising an HPPD-inhibiting herbicide in the form of an agrochemically acceptable salt and an insecticide is disclosed, provided that the HPPD inhibiting herbicide is not a compound of formula (A) wherein Ra is C1-2 alkyl or chloro; Rb is hydrogen or C1-4 alkyl; and Rc is C1-4 alkyl is disclosed.
    Type: Grant
    Filed: November 3, 2004
    Date of Patent: July 5, 2011
    Assignee: Syngenta Crop Protection LLC
    Inventors: Christopher Glen Clemens, Willy Thaddaeus Rueegg, Michael Joseph Urwiler
  • Publication number: 20100261682
    Abstract: The present invention relates to the treatment of cachexia in a mammal by the use of a compound comprising a high density negatively charged domain of vicinally oriented radicals.
    Type: Application
    Filed: September 17, 2008
    Publication date: October 14, 2010
    Inventors: Matti Sirén, Pontus Gallen-Kallela-Sirén
  • Publication number: 20100047308
    Abstract: A method is provided for producing a virus-inactivated, acellular implant for the human body, featuring the use of TNBP in combination with a detergent selected from among deoxycholate, SDS, Tween 80, Triton X-100, sodium cholate and combinations thereof for removing cells and viruses simultaneously. Also disclosed are an acellular human body implant produced by the method and a wound healing agent comprising the acellular human body implant.
    Type: Application
    Filed: September 28, 2007
    Publication date: February 25, 2010
    Inventors: Jin Young Kim, In Seop Kim, Jae Hyoung Ahn, Hyo Sun Jeong, Seok Beam Song, Ji Hwa Chae, Seog Jin Seo, Ke Won Kang, Ho Chan Hwang
  • Publication number: 20090281062
    Abstract: The invention relates to nitroso derivatives including carboxylic acid and phosphoric acid esters of hydroxy nitroso compounds that donate nitroxyl (HNO) under physiological conditions. The compounds and compositions of the invention are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure, ischemia/reperfusion injury and cancer.
    Type: Application
    Filed: May 7, 2009
    Publication date: November 12, 2009
    Inventors: Lisa M. Frost, Stephen M. Courtney, Frederick A. Brookfield, Vincent J. Kalish
  • Publication number: 20090075947
    Abstract: The present application describes deuterium-enriched fospropofol, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.
    Type: Application
    Filed: August 22, 2008
    Publication date: March 19, 2009
    Applicant: PROTIA, LLC
    Inventor: Anthony W. Czarnik
  • Patent number: 7402302
    Abstract: Compositions and methods for attracting, capturing and killing populations of cotton boll weevils (Anthonomus grandis Boh.) in boll weevil traps are disclosed. With respect to the attraction and capture of boll weevils with Grandlure, the synthetic pheromone of the cotton boll weevil, there is generally an increased number of boll weevils captured in the trap cylinder when an insecticide dispenser is included in the trap cylinder to kill the weevils and thus prevent their escape. Additionally, dead boll weevils are more accurately counted than live boll weevils. The compound dichlorvos (2,2-dichlorovinyl dimethyl phosphate or DDVP) is the most preferred among those few insecticides that can be used in traps for killing and preventing weevil escapes. This is also the preferred insecticide when combined with Grandlure in a single dispenser to kill boll weevils or inhibit their ability to develop normally and reproduce.
    Type: Grant
    Filed: January 7, 2004
    Date of Patent: July 22, 2008
    Inventors: Thomas Alfred Plato, James Clayton Plato, James Scott Plato, Stacy Elizabeth Plato, Timothy Bruce Johnson
  • Publication number: 20080171726
    Abstract: The present invention concerns the use of oxygen antagonists and other active compounds for inducing stasis or pre-stasis in cells, tissues, and/or organs in vivo or in an organism overall, in addition to enhancing their survivability. It includes compositions, methods, articles of manufacture and apparatuses for enhancing survivability and for achieving stasis or pre-stasis in any of these biological materials, so as to preserve and/or protect them. In specific embodiments, there are also therapeutic methods and apparatuses for organ transplantation, hyperthermia, wound healing, hemorrhagic shock, cardioplegia for bypass surgery, neurodegeneration, hypothermia, and cancer using the active compounds described.
    Type: Application
    Filed: August 12, 2007
    Publication date: July 17, 2008
    Inventors: Mark B. Roth, Mike Morrison, Eric Blackstone, Dana Miller
  • Patent number: 7217704
    Abstract: The present invention relates to compounds according to formula (I) as disclosed herein as well as pharmaceutical compositions which include those compounds. Also disclosed are methods of using such compounds, which have activity as agonists or as antagonists of LPA receptors; such methods including inhibiting LPA activity on an LPA receptor, modulating LPA receptor activity, treating cancer, enhancing cell proliferation, treating a wound, treating apoptosis or preserving or restoring function in a cell, tissue, or organ, culturing cells, preserving organ or tissue function, and treating a dermatological condition.
    Type: Grant
    Filed: October 12, 2004
    Date of Patent: May 15, 2007
    Assignee: The University of Tennessee Research Foundation
    Inventors: Duane D. Miller, Gabor Tigyi, Gangadhar G. Durgam, Tamas Virag, Michelle D. Walker, Ryoko Tsukahara
  • Patent number: 7192940
    Abstract: The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising an ether compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
    Type: Grant
    Filed: July 16, 2004
    Date of Patent: March 20, 2007
    Assignee: Esperion Therapeutics, Inc.
    Inventors: Jean-Louis Henri Dasseux, Carmen Daniela Oniciu
  • Patent number: 6774123
    Abstract: Methods and compositions for selectively inactivating viruses in biological compositions, including contacting the composition with an organic solvent and an ethyleneimine oligomer inactivating agent, are disclosed.
    Type: Grant
    Filed: July 28, 1999
    Date of Patent: August 10, 2004
    Assignee: V.I. Technologies, Inc.
    Inventors: Edward I. Budowsky, Samuel K. Ackerman, Andrei A. Purmal, Clark M. Edson, Martin D. Williams
  • Patent number: 6649646
    Abstract: The invention relates to an insecticidal and miticidal composition which contains as active ingredients chlorfenapyr in combination with one or more organophosphoric acid ester-type compounds and to a method for controlling insecticidal or miticidal pests which have acquired resistance to commercial insecticidal and miticidal agents.
    Type: Grant
    Filed: September 28, 2001
    Date of Patent: November 18, 2003
    Assignee: BASF Aktiengesellschaft
    Inventor: Toshiki Fukuchi
  • Publication number: 20030186845
    Abstract: Provided is a composition for preventing urinary calculi caused by metal ions liberated from a compound containing a lanthanoid metal or another heavy metal in image diagnosis or therapy using that compound. The composition is a urinary calculus preventing composition containing a multidentate ligand capable of forming a complex with lanthanoid metal ions or other heavy metal ions, or an alkaline earth metal complex of that ligand. The multidentate ligand can be a bifunctional ligand having a polyaminopolycarboxylic acid, polyaminopolyphosphonic acid or the like as its site for forming a complex with a metal and chemically bonded to a physiologically acceptable oligosaccharide or the like, or can also be a polyaminopolycarboxylic or polyaminopolyphosphonic acid per se. Preferably, the polyaminopolycarboxylic acid is EDTA, DTPA, DOTA or TETA, or a derivative thereof.
    Type: Application
    Filed: February 4, 2003
    Publication date: October 2, 2003
    Inventor: Yasunori Yoshida
  • Patent number: 6566304
    Abstract: The invention relates to use of (a) compounds of phosphorus containing at least partly lipophilic organic radicals together with (b) urea and/or urea derivatives in selected quantity ratios of (a) to (b) as a soil additive for biologically controlling plant-parasitic soil nematodes by strengthening the correspondingly antagonistic soil potential, more particularly by strengthening the growth of antagonistic and/or nematicidal rhizosphere bacteria and/or corresponding mycorrhiza strains—and at the same time strengthening the growth of cultivated plants in soil. The multicomponent mixtures which strengthen bacterial growth are preferably introduced into the region of the plant roots in the form of an aqueous preparation using plant-compatible emulsifiers before and/or during plant growth. Components (a) and (b) are used in such quantity ratios that the ratio by weight of C to N is no higher than 6:1 and preferably no higher than 5:1.
    Type: Grant
    Filed: February 6, 2001
    Date of Patent: May 20, 2003
    Assignee: Cognis Deutschland GmbH
    Inventors: Doris Bell, Bettina Kopp-Holtwiesche, Stephan Von Tapavicza
  • Patent number: 6562845
    Abstract: The subject invention provides materials and methods for the effective control of fruit flies. Specifically, the subject invention pertains to the use of imidacloprid compounds to control fruit flies. These compounds achieve a high level of control without mammalian toxicity.
    Type: Grant
    Filed: January 22, 2001
    Date of Patent: May 13, 2003
    Assignee: University of Florida
    Inventors: Herbert N. Nigg, Samuel E. Simpson
  • Publication number: 20020173489
    Abstract: The object of the invention is to provide a medicament which is suitable for the treatment of tumors, such as via topical administration.
    Type: Application
    Filed: February 26, 1999
    Publication date: November 21, 2002
    Inventor: HANSJORG EIBL
  • Patent number: 6369048
    Abstract: Methods and compositions for selectively inactivating viruses in biological compositions, including contacting the composition with an organic solvent and an ethyleneimine oligomer inactivating agent, are disclosed.
    Type: Grant
    Filed: January 12, 1998
    Date of Patent: April 9, 2002
    Assignee: V.I. Technologies, Inc.
    Inventors: Edward I. Budowsky, Samuel K. Ackerman, Andrei A. Purmal, Clark M. Edson, Martin D. Williams
  • Patent number: 6313106
    Abstract: The present invention relates to compounds, which are phospholipid derivatives of valproic acid, to compositions comprising said compounds and their use for treating epilepsy, migraine, bipolar disorders and pain.
    Type: Grant
    Filed: July 12, 2000
    Date of Patent: November 6, 2001
    Assignee: D-Pharm Ltd.
    Inventor: Alexander Kozak
  • Patent number: 6274570
    Abstract: A liquid pesticidal composition, which is substantially free of water, comprising a hydrophobic pesticide or mixture of pesticides dissolved in an organic solvent and comprising as surfactants (a) a castor oil ethoxylate having 30-50 mol ethoxylate, (b) a branched C8-C18 alcohol ethoxylate having 5-10 mol ethoxylate, and (c) a tristyrenephenol-ethoxylate having 8-30 mol ethoxylate, or its phosphate or salt thereof. The compositions also include gels having a viscosity of 500 to 20,000 mPas and comprising additionally a gelling agent.
    Type: Grant
    Filed: December 22, 1998
    Date of Patent: August 14, 2001
    Assignee: Syngenta Crop Protection, Inc.
    Inventors: Manfred Vogt, William Baettig
  • Publication number: 20010008874
    Abstract: A microcapsule (or microencapsulated product) having a uniform and smooth coating film and also an excellent performance of gradually liberating the content material is produced at a good particle size distribution while suppressing the occurrence of isolated or aggregated film material, aggregated microcapsules and isolated core material. The production process includes: a first coating step of mixing a water-soluble cationic amino resin and an anionic surfactant in the presence of a hydrophobic core material dispersed in an aqueous medium to coat the dispersed core material with a coacervate of the cationic amino resin and the anionic surfactant; and a second coating step of adding an amino resin prepolymer into an aqueous dispersion liquid containing the coated dispersed core material and polycondensating the amino resin prepolymer to further coat the coated dispersed core material with a polycondensate of the amino resin prepolymer.
    Type: Application
    Filed: January 12, 2001
    Publication date: July 19, 2001
    Inventors: Yutaka Igari, Yuzi Hori, Tsuneo Okamoto
  • Patent number: 6197777
    Abstract: A method and composition for the treatment of HIV infection, HBV infection, or abnormal cellular proliferation in humans and other host animals is disclosed that includes the administration of an effective amount of a 1,3-oxaselenolane nucleoside or a pharmaceutically acceptable salt thereof, optionally in a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: March 3, 2000
    Date of Patent: March 6, 2001
    Assignees: Emory University, The University of Georgia Research Foundation, Inc.
    Inventors: Raymond F. Schinazi, Chung K. Chu, Jinfa Du
  • Patent number: 6166089
    Abstract: The invention relates to a pharmaceutically acceptable prodrug which is a covalent conjugate of a pharmacologically active compound and an intracellular transporting adjuvant, characterized by the presence of a covalent bond which is scission-sensitive to intracellular enzyme activity. The prodrug may be used in a technique for treating a condition or disease in a mammal related to supranormal intracellular enzyme activity, whereby on administering it to a human having such condition or disease, the bond is broken in response to such activity, and the pharmacologically active compound is activated selectively within cells having such supranormal intracellular enzyme activity.
    Type: Grant
    Filed: October 28, 1999
    Date of Patent: December 26, 2000
    Assignee: D-Pharm, Ltd.
    Inventor: Alexander Kozak
  • Patent number: 6162825
    Abstract: This invention relates to the discovery that in many strains of the German cockroach [Blattella, germanica (L.)], feeding is inhibited by high glucose levels, while conversely, feeding of this strain of cockroach is stimulated by high or ultra high levels of fructose. Therefore, preferred bait compositions of the instant invention relate to insecticide bait compositions for insect control which contain a ratio of fructose to glucose of no less than about 9:1 and as great as about 10:0, binder and an avermectin insecticide.
    Type: Grant
    Filed: April 16, 1999
    Date of Patent: December 19, 2000
    Assignee: The Clorox Company
    Inventors: Jules Silverman, Donald N. Bieman
  • Patent number: 6110904
    Abstract: A method for suppressing plant damage by nematodes which comprises the concurrent administration, to the locus, soil or seeds of plants in need of such treatment, of (a) a metabolite of the fungus Myrothecium verrucaria and (b) a chemical pesticide, as well as synergistic nematocidal compositions useful therein.
    Type: Grant
    Filed: August 28, 1997
    Date of Patent: August 29, 2000
    Assignee: Valent BioSciences, Inc.
    Inventors: Prem Warrior, Daniel F. Heiman, Linda A. Rehberger
  • Patent number: 6077837
    Abstract: The invention relates to a pharmaceutically acceptable prodrug which is a covalent conjugate of a pharmacologically active compound and an intracellular transporting adjuvant, characterized by the presence of a covalent bond which is scission-sensitive to intracellular enzyme activity. The prodrug may be used in a technique for treating a condition or disease in a mammal related to supranormal intracellular enzyme activity, whereby on administering it to a human having such condition or disease, the bond is broken in response to such activity, and the pharmacologically active compound is activated selectively within cells having such supranormal intracellular enzyme activity.
    Type: Grant
    Filed: October 23, 1998
    Date of Patent: June 20, 2000
    Assignee: D-Pharm Ltd.
    Inventor: Alexander Kozak
  • Patent number: 5972915
    Abstract: A pesticide comprising an active ingredient combination consisting ofa) tetrahydro-3,5-dimethyl-1,3,5-thiadiazine-2-thione of the formula ##STR1## and b) O-(O-ethyl-S-n-propylphosphoryl)-O-(N-methylcarbamoyl)pyrocatechol of the formula ##STR2## and/or c) O-ethyl S,S-dipropyl phosphorodithioate of the formula ##STR3## and/or d) 2-methyl-2-methylthiopropionaldehyde O-methylcarbamoyloxime of the formula ##STR4## and/or e) N,N-dimethyl-2-methylcarbamoyloximino-2-methylthioacetamide of the formula ##STR5## and/or f) ethyl-4-methylthio-m-tolylisopropylphosphoramide of the formula ##STR6## and/or g) (RS)-S-sec-butyl O-ethyl 2-oxo-1,3-thiazolidin-3-ylphosphono-thioate of the formula ##STR7## and/or h) 2,3-dihydro-2,2-dimethylbenzofuran-7-yl methylcarbamate of the formula ##STR8## and/or i) S-tert-butylthiomethyl O,O-diethyl phosphorodithioate of the formula ##STR9## and/or j) S,S-di-sec-butyl O-ethyl phosphorodithioate of the formula ##STR10## and/or k) (RS)-O-1-(4-chlorophenyl)pyrazol-4-yl O-ethyl S-propyl phosphoro
    Type: Grant
    Filed: October 9, 1997
    Date of Patent: October 26, 1999
    Assignee: BASF Aktiengesellschaft
    Inventors: Peter Hofmeister, Ulrich Neumann, Volker Harries, Jurgen von der Heyde, Manfred Schroeder, Jorn Tidow, Matthias Bratz, Karl-Friedrich Jager
  • Patent number: 5962322
    Abstract: Methods for regulation of lipid and cholesterol uptake are described which are based on regulation of the expression or function of the SR-BI HDL receptor. The examples demonstrate that estrogen dramatically downregulates SR-BI under conditions of tremendous upregulation of the LDL-receptor. The examples also demonstrate the upregulation of SR-BI in rat adrenal membranes and other non-placental steroidogenic tissues from animals treated with estrogen, but not in other non-placental non-steroidogenic tissues, including lung, liver, and skin. Examples further demonstrate the uptake of fluorescently labeled HDL into the liver cells of animal, which does not occur when the animals are treated with estrogen. Examples also demonstrate the in vivo effects of SR-BI expression on HDL metabolism, in mice transiently overexpressing hepatic SR-BI following recombinant adenovirus infection. Overexpression of the SR-BI in the hepatic tissue caused a dramatic decrease in cholesterol blood levels.
    Type: Grant
    Filed: November 15, 1996
    Date of Patent: October 5, 1999
    Assignees: Massachusetts Institute of Technology, The Trustees of the University of Pennsylvania
    Inventors: Karen Kozarsky, Attilio Rigotti, Monty Krieger
  • Patent number: 5929121
    Abstract: A method for the protection of trees of the families Musaceae or Plantanginaceae from destructive pests whereby the trees to be protected share a common root system.
    Type: Grant
    Filed: December 13, 1996
    Date of Patent: July 27, 1999
    Assignee: Rhone-Poulenc Agro
    Inventors: Jorge Cepeda, Juan Bocanegra
  • Patent number: 5925670
    Abstract: This invention relates to the discovered that in many strains of the German cockroach ?Blattella germanica (L.)!, feeding is inhibited by high glucose levels, conversely, feeding of this strain of cockroach is stimulated by high or ultra high levels of fructose; therefore, preferred bait compositions of the instant invention relate to insecticide bait compositions for insect control which contain a ratio of fructose to glucose of no less that about 9:1 and as great as about 10:0, binder and a preferred pyrimidinono hydrazone.
    Type: Grant
    Filed: August 4, 1997
    Date of Patent: July 20, 1999
    Assignee: The Clorox Company
    Inventors: Jules Silverman, Donald N. Bieman
  • Patent number: 5888991
    Abstract: The invention concerns the use of phosphorus derivatives of alkaloids of the general formula (I), for preparing a medicament for treating endocrinopathies, in particular for treating osteoporosis.
    Type: Grant
    Filed: July 9, 1996
    Date of Patent: March 30, 1999
    Inventor: Wassyl Nowicky
  • Patent number: 5866548
    Abstract: Caged acyloxyalkyl esters of phosphate-containing inositol phosphates which are capable of permeating cell membranes. The second messengers are protected (caged) at the 6-hydroxyl, with a photolabile group. Once inside the cell, the ester derivatives undergo enzymatic conversion to remove the acyloxyalkyl ester groups. The resulting caged compound remains biologically inactive until exposed to ultraviolet (UV) light. Upon UV light exposure, the active form of the second messenger is released within the cell.
    Type: Grant
    Filed: December 19, 1996
    Date of Patent: February 2, 1999
    Assignee: The Regents of the University of California
    Inventors: Roger Y. Tsien, Wenhong Li
  • Patent number: 5834436
    Abstract: Acyloxyalkyl esters of phosphate-containing second messengers which are capable of permeating cell membranes. Once inside the cell, the ester derivatives undergo enzymatic conversion to the biologically active form of the second messenger. The acyloxyalkyl esters have the formula: ##STR1## wherein A.sub.1 to A.sub.6 is H, OH, F or ##STR2## wherein R is an alkyl group having from 2 to 6 carbon atoms and R' is H or CH.sub.3 or R is CH.sub.3 and R' is CH.sub.3 and wherein at least one of A.sub.1 to A.sub.6 is a phosphoester having the formula set forth above.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: November 10, 1998
    Assignee: The Regents of the University of California
    Inventors: Roger Y. Tsien, Carsten Schultz, Wenhong Li
  • Patent number: 5760022
    Abstract: The invention relates to an inositol phosphate containing pharmaceutical composition which comprises an aliphatic ester or ether for improvement of the bioavailability of the inositol phosphate in mammals including man at non-parenteral administration. The invention also covers the use of at least one aliphatic ester or ether compound for the preparing of an inositol phosphate containing medicament with improved bioavailability of inositol phosphate in mammals including man at non-parenteral administration.
    Type: Grant
    Filed: July 17, 1996
    Date of Patent: June 2, 1998
    Assignee: Perstorp AB
    Inventors: Lars Persson, Torgny Gustafsson, Nicola Rehnberg
  • Patent number: 5514639
    Abstract: The invention provides a concentrate for dilution with water in the preparation of an agriculatural composition for application to crops, soil or animals and comprising an agricultural chemical whose agricultural activity varies with the pH of the water; and the invention provides a method of preparing such agricultural composition by mixing the concentrate with water and effecting such pH modification to the composition as is necessary to obtain a pH in the composition at which the agricultural activity of the chemical is acceptable. The concentrate comprises an active ingredient and a pH indicator for colouring the water, and the proportions of pH indicator and active ingredient are selected so that when the concentrate is diluted with water to provide an effective concentration of active ingredient in the water, the pH indicator indicates visually whether or not the pH of the water is suitable for acceptable agricultural activiy of the chemical.
    Type: Grant
    Filed: October 1, 1993
    Date of Patent: May 7, 1996
    Assignee: Gouws & Scheepers (Proprietary) Limited
    Inventors: Jonah Fisher, Martin D. Bloomberg
  • Patent number: 5447923
    Abstract: Methods for the treatment of a human or lower animal subject having an H. pylori-mediated upper gastrointestinal disorder comprising administering to said subject a safe and effective amount of a diphenyl ether phosphate ester of the following formula: ##STR1## wherein n is an integer from 0 to 3, or a pharmaceutically-acceptable salt thereof.
    Type: Grant
    Filed: October 11, 1994
    Date of Patent: September 5, 1995
    Assignee: The Proctor & Gamble Company
    Inventors: Carl E. Catrenich, Dennis G. A. Nelson
  • Patent number: 5260287
    Abstract: Compositions and methods for protecting the luminal lining against gastric acid challenge are disclosed. The compositions provide effective anti-ulcer preparations which include phosphorylated alcohol. Phosphorylated alcohols comprise the active anti-ulcerogenic ingredient of the described therapeutic formulations. The preparation of unique linear and cyclic polyphosphorylated alcohols and methods of using same to protect the stomach luminal lining against acid challenge are also disclosed. Inositol hexaphosphate and mannitol hexaphosphate are demonstrated to provide therapeutic value in the treatment and prevention of gastro-erosive disease precipitated by exposure of biological tissues to highly acidic substances, for example, the gastric digestive acids. While inositol hexaphosphate alone at subthreshold concentrations provides a small gastro-protective activity, a combination of inositol hexaphosphate (at subthreshold concentrations) with polyvalent cations, such as Au.sup.+3 or Bi.sup.
    Type: Grant
    Filed: May 11, 1992
    Date of Patent: November 9, 1993
    Assignee: Board of Regents, The University of Texas System
    Inventors: Jose C. Barreto, Lenard M. Lichtenberger
  • Patent number: 5182271
    Abstract: The invention discloses certain thioether, keto-ester and alkyl phospholipids which are useful in treating multiple sclerosis.
    Type: Grant
    Filed: August 30, 1991
    Date of Patent: January 26, 1993
    Assignee: Sandoz Ltd.
    Inventor: William J. Houlihan
  • Patent number: 5164383
    Abstract: O-Halogenocyclopentyl S-alkyl (di)thiphosphoric(phosphonic) acid ester derivatives of the general formula (I) ##STR1## in which R.sup.1 represents alkyl, alkoxy or the radical ##STR2## R.sup.3 represents hydrogen or alkyl and R.sup.4 represents hydrogen, alkyl, --COH (formyl) or optionally halogen-substituted --CO-alkyl (acyl),R.sup.2 represents alkyl or alkoxyalkyl andX represents oxygen or sulphur,can be used as pesticides.
    Type: Grant
    Filed: March 20, 1992
    Date of Patent: November 17, 1992
    Assignee: Bayer Aktiengesellschaft
    Inventors: Bernd-Wieland Kruger, Michael Negele, Jurgen Hartwig, Christoph Erdelen, Wilhelm Stendel