ACTIVE COMPOUND COMBINATIONS

Abstract

The invention relates to active compound combinations, in particular within a composition, which comprises (A) an amidine compound of formula (I) and a further fungicidally (B-1), insecticidally (B-2) active or plant growth regulating compound (B-3). Moreover, the invention relates to a method for curatively or preventively controlling the phytopathogenic fungi of plants or reducing the mycotoxin contamination of plant or plant parts, to the use of a combination according to the invention for the treatment of seed, to a method for protecting a seed and not at least to the treated seed.

Description

The invention relates to active compound combinations, in particular within a composition, which comprises (A) an amidine compound of formula (I) and a further fungicidally (B-1), insecticidally (B-2) active or plant growth regulating compound (B-3). Moreover, the invention relates to a method for curatively or preventively controlling the phytopathogenic fungi of plants or reducing the mycotoxin contamination of plant or plant parts, to the use of a combination according to the invention for the treatment of seed, to a method for protecting a seed and not at least to the treated seed.

WO-A-00/046 184 and WO-A-03/093 224 each disclose the use of arylamidines as fungicides.

WO-A-03/024 219, WO-A-05/089 547 and WO-A-05/120 234 each disclose fungicide combinations comprising at least one phenylamidine and at least one further known fungicidally active ingredient.

The unpublished international patent application PCT/EP/2009/004419 discloses thiadiazolyloxyphenylamidine compounds according to formula (I), methods for producing such compounds starting from commercially available ingredients and its fungicidal uses. The disclosure of this application shall be fully incorporated herein by reference.

In conjunction with the present invention, the term plant growth regulator (PGRs) denotes an active ingredient or a combination of such a.i.s, which influences germination, growth, maturation or development of plants or its fruits.

Since, moreover, the environmental and economic requirements imposed on modern-day fungicides are continually increasing, with regard, for example, to the spectrum of action, toxicity, selectivity, application rate, formation of residues, and favourable preparation ability, and since, furthermore, there may be problems, for example, with resistances, it is constant task to develop new fungicide agents which in some areas at least have advantages over their known counterparts.

The invention provides active compound combinations/compositions which in some aspects at least achieve the stated objectives.

It has now been found, surprisingly, that the combinations according to the invention not only bring about the additive enhancement of the spectrum of action with respect to the phytopathogen to be controlled that was in principle to be expected but achieves a synergistic effect which extends the range of action of the component (A) and of the component (B) in two ways. Firstly, the rates of application of the component (A) and of the component (B) are lowered whilst the action remains equally good. Secondly, the combination still achieves a high degree of phytopathogen control and reduction in mycotoxin contamination even where the two individual compounds have become totally ineffective in such a low application rate range. This allows, on the one hand, a substantial broadening of the spectrum of phytopathogens that can be controlled and, on the other hand, increased safety in use.

However, besides the actual synergistic action with respect to fungicidal and mycotoxin-reducing activity, the combinations according to the invention also have further surprising advantageous properties which can also be described, in a wider sense, as synergistic activity. Examples of such advantageous properties that may be mentioned are: a broadening of the spectrum of fungicidal activity to other phytopathogens, for example to resistant strains; a reduction in the rate of application of the active ingredients; adequate pest control with the aid of the compositions according to the invention, even at a rate of application at which the individual compounds are totally ineffective; advantageous behaviour during formulation or upon application, for example upon grinding, sieving, emulsifying, dissolving or dispensing; increased storage stability; improved stability to light; more advantageous degradability; improved toxicological or ecotoxicological behaviour; improved characteristics of the useful plants including: emergence, crop yields, more developed root system, tillering increase, increase in plant height, bigger leaf blade, less dead basal leaves, stronger tillers, greener leaf color, less fertilizers needed, less seeds needed, more productive tillers, earlier flowering, early grain maturity, less plant verse (lodging), increased shoot growth, improved plant vigor, and early germination; or any other advantages familiar to a person skilled in the art.

The combination according to the invention can also provide an improved systemicity to the active compounds that are used. Indeed, even if some of the used fungicide compounds do not possess any or a satisfying systemicity, within the composition according to the invention these compounds can exhibit such a property.

In a similar manner, the combination according to the invention can allow an increased persistence of the fungicide efficacy of the active compounds that are employed.

Another advantage of the combination according to the invention relies in that an increased curativity is achievable.

Accordingly, the present invention provides a combination comprising:

(A) At least one compound according to formula (I)

• • wherein
  • R¹ is selected from the group consisting of hydrogen-a mercapto- (—SH) and a methyl group;
  • R² is selected from the group consisting of a methyl- and an ethyl group;
  • R³ is selected from the group consisting of a methyl-, an ethyl- and an isopropyl group;
  • alternatively R² and R³ can form, together with the N-atom, to which they are attached to, a piperidyl-, a pyrrolidyl- or a 2,6-dimethylmorpholinyl-ring;
  • R⁴ is selected from the group consisting of a chlorine- or a fluorine atom, a trifluoromethyl-, a difluoromethyl- and a methyl group;
  • R⁵ and R⁶ independently from each other, is selected from the group consisting of a hydrogen atom, a methyl- and an ethyl group; or can form, together with the C-atom, to which they are attached to, a cyclopropyl ring;
  • R⁷ is selected from the group consisting of a chlorine atom, a tert-butyl-, a methoxy-, an ethoxy-, a trimethylsilyl- and a triethylsilyl-group,
  • n is 1
  • and salts or stereoisomers thereof,
  • and
• (B-I) at least one farther active compound selected from the group consisting of
  • (B-I.1) Inhibitors of the ergosterol biosynthesis, for example (1.1) aldimorph (1704-28-5), (1.2) azaconazole (60207-31-0), (1.3) bitertanol (55179-31-2), (1.4) bromuconazole (116255-48-2), (1.5) cyproconazole (113096-99-4), (1.6) diclobutrazole (75736-33-3), (1.7) difenoconazole (119446-68-3), (1.8) diniconazole (83657-24-3), (1.9) diniconazole-M (83657-18-5), (1.10) dodemorph (1593-77-7), (1.11) dodemorph acetate (31717-87-0), (1.12) epoxiconazole (106325-08-0), (1.13) etaconazole (60207-93-4), (1.14) fenarimol (60168-88-9), (1.15) fenbuconazole (114369-43-6), (1.16) fenhexamid (126833-17-8), (1.17) fenpropidin (67306-00-7), (1.18) fenpropimorph (67306-03-0), (1.19) fluquinconazole (136426-54-5), (1.20) flurprimidol (56425-91-3), (1.21) flusilazole (85509-19-9), (1.22) flutriafol (76674-21-0), (1.23) furconazole (112839-33-5), (1.24) furconazole-cis (112839-32-4), (1.25) hexaconazole (79983-71-4), (1.26) imazalil (60534-80-7), (1.27) imazalil sulfate (58594-72-2), (1.28) imibenconazole (86598-92-7), (1.29) ipconazole (125225-28-7), (1.30) metconazole (125116-23-6), (1.31) myclobutanil (88671-89-0), (1.32) naftifine (65472-88-0), (1.33) nuarimol (63284-71-9), (1.34) oxpoconazole (174212-12-5), (1.35) paclobutrazol (76738-62-0), (1.36) pefurazoate (101903-30-4), (1.37) penconazole (66246-88-6), (1.38) piperalin (3478-94-2), (1.39) prochloraz (67747-09-5), (1.40) propiconazole (60207-90-1), (1.41) prothioconazole (178928-70-6), (1.42) pyributicarb (88678-67-5), (1.43) pyrifenox (88283-41-4), (1.44) quinconazole (103970-75-8), (1.45) simeconazole (149508-90-7), (1.46) spiroxamine (118134-30-8), (1.47) tebuconazole (107534-96-3), (1.48) terbinafine (91161-71-6), (1.49) tetraconazole (112281-77-3), (1.50) triadimefon (43121-43-3), (1.51) triadimenol (89482-17-7), (1.52) tridemorph (81412-43-3), (1.53) triflumizole (68694-11-1), (1.54) triforine (26644-46-2), (1.55) triticonazole (131983-72-7), (1.56) uniconazole (83657-22-1), (1.57) viniconazole (77174-66-4), (1.58) 1-(4-chlorophenyl)-2-(1H-1,2,4-triazol-1-yl)cycloheptanol (129586-32-9), (1.59) methyl 1-(2,2-dimethyl-2,3-dihydro-1H-inden-1-yl)-1H-imidazole-5-carboxylate (111323-95-0), (1.60) O-{1-[(4-methoxyphenoxy)methyl]-2,2-dimethylpropyl} 1H-imidazole-1-carbothioate (111226-71-2), (1.61) N′-{5-(difluoromethyl)-2-methyl-4-[3-(trimethylsilyl)-propoxy]phenyl}-N-ethyl-N-methylimidoformamide, (1.62) N-ethyl-N-methyl-N′-{2-methyl-5-(trifluoromethyl)-4-[3-(trimethylsilyl)propoxy]-phenyl}imidoformamide, (1.63) voriconazole (137234-62-9),
  • (B-I.2) inhibitors of the respiratory chain at complex I or II, for example (2.1) diflumetorim (130339-07-0), (2.2) bixafen (581809-46-03), (2.3) boscalid (188425-85-6), (2.4) carboxin (5234-68-4), (2.5) fenfuram (24691-80-3), (2.6) fluopyram (658066-35-4), (2.7) flutolanil (66332-96-5), (2.8) furametpyr (123572-88-3), (2.9) furmecyclox (60568-05-0), (2.10) isopyrazam (mixture of syn-epimeric racemate 1RS,4SR,9RS and anti-epimeric racemate 1RS,4SR,9SR) (88165-58-1), (2.11) isopyrazam (syn epimeric racemate 1RS,4SR,9RS), (2.12) isopyrazam (syn-epimeric enantiomer 1R,4 S,9R), (2.13) isopyrazam (syn-epimeric enantiomer 1S,4R,9S), (2.14) isopyrazam (anti-epimeric racemate 1RS,4SR,9SR), (2.15) isopyrazam (anti-epimeric enantiomer 1R,4S,9S), (2.16) isopyrazam (anti-epimeric enantiomer 1S,4R,9R), (2.17) mepronil (55814-41-0), (2.18) oxycarboxin (5259-88-1), (2.19) penflufen (494793-67-8), (2.20) penthiopyrad (183675-82-3), (2.21) sedaxane (874967-67-6), (2.22) thifluzamide (130000-40-7), (2.23) 1-methyl-N-[2-(1,1,2,2-tetrafluoroethoxy)phenyl]-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide, (2.24) 3-(difluoromethyl)-1-methyl-N-[2-(1,1,2,2-tetrafluoroethoxy)phenyl]-1H-pyrazole-4-carboxamide, (2.25) 3-(difluoromethyl)-N-[4-fluoro-2-(1,1,2,3,3,3-hexafluoropropoxy)phenyl]-1-methyl-1H-pyrazole-4-carboxamide, (2.26) 1-methyl-3-(trifluoromethyl)-N-[2′-(trifluoromethyl)biphenyl-2-yl]-1H-pyrazole-4-carboxamide, (2.27) N-(4′-chlorobiphenyl-2-yl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide, (2.28) N-(2′,4′-dichlorobiphenyl-2-yl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide, (2.29) 3-(difluoromethyl)-1-methyl-N-[4′-(trifluoromethyl)biphenyl-2-yl]-1H-pyrazole-4-carboxamide, (2.30) N-(2′,5′-difluorobiphenyl-2-yl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide, (2.31) 3-(difluoro-methyl)-1-methyl-N-[4′-(prop-1-yn-1-yl)biphenyl-2-yl]-1H-pyrazole-4-carboxamide (known from WO 2004/058723), (2.32) 5-fluoro-1,3-dimethyl-N-[4′-(prop-1-yn-1-yl)biphenyl-2-yl]-1H-pyrazole-4-carboxamide (known from WO 2004/058723), (2.33) 2-chloro-N-[4′-(prop-1-yn-1-yl)biphenyl-2-yl]pyridine-3-carboxamide (known from WO 2004/058723), (2.34) 3-(difluoromethyl)-N-[4′-(3,3-dimethylbut-1-yn-1-yl)biphenyl-2-yl]-1-methyl-1H-pyrazole-4-carboxamide (known from WO 2004/058723), (2.35) N-[4′-(3,3-dimethylbut-1-yn-1-yl)biphenyl-2-yl]-5-fluoro-1,3-dimethyl-1H-pyrazole-4-carboxamide (known from WO 2004/058723), (2.36) 3-(difluoromethyl)-N-(4′-ethynylbiphenyl-2-yl)-1-methyl-1H-pyrazole-4-carboxamide (known from WO 2004/058723), (2.37) N-(4′-ethynylbiphenyl-2-yl)-5-fluoro-1,3-dimethyl-1H-pyrazole-4-carboxamide (known from WO 2004/058723), (2.38) 2-chloro-N-(4′-ethynylbiphenyl-2-yl)pyridine-3-carboxamide (known from WO 2004/058723), (2.39) 2-chloro-N-[4′-(3,3-dimethylbut-1-yn-1-yl)biphenyl-2-yl]pyridine-3-carboxamide (known from WO 2004/058723), (2.40) 4-(difluoromethyl)-2-methyl-N-[4′-(trifluoromethyl)biphenyl-2-yl]-1,3-thiazole-5-carboxamide (known from WO 2004/058723), (2.41) 5-fluoro-N-[4′-(3-hydroxy-3-methylbut-1-yn-1-yl)biphenyl-2-yl]-1,3-dimethyl-1,4-pyrazole-4-carboxamide (known from WO 2004/058723), (2.42) 2-chloro-N-[4′-(3-hydroxy-3-methylbut-1-yn-1-yl)biphenyl-2-yl]pyridine-3-carboxamide (known from WO 2004/058723), (2.43) 3-(difluoromethyl)-N-[4′-(3-methoxy-3-methylbut-1-yn-1-yl)biphenyl-2-yl]-1-methyl-1H-pyrazole-4-carboxamide (known from WO 2004/058723), (2.44) 5-fluoro-N-[4′-(3-methoxy-3-methylbut-1-yn-1-yl)biphenyl-2-yl]-1,3-dimethyl-1H-pyrazole-4-carboxamide (known from WO 2004/058723), (2.45) 3-(difluoromethyl)-1-methyl-N-(3′,4′,5′-trifluorobiphenyl-2-yl)-1H-pyrazole-4-carboxamide, (2.46) 2-chloro-N-[4′-(3-methoxy-3-methylbut-1-yn-1-yl)biphenyl-2-yl]pyridine-3-carboxamide (known from WO 2004/058723) and salts or stereoisomers thereof,
  • (B-I.3) inhibitors of the respiratory chain at complex III, for example (3.1) amisulbrom (348635-87-0), (3.2) azoxystrobin (131860-33-8), (3.3) cyazofamid (120116-88-3), (3.4) dimoxystrobin (141600-52-4), (3.5) enestroburin (238410-11-2), (3.6) famoxadone (131807-57-3), (3.7) fenamidone (161326-34-7), (3.8) fluoxastrobin (361377-29-9), (3.9) kresoxim-methyl (143390-89-0), (3.10) metominostrobin (133408-50-1), (3.11) orysastrobin (189892-69-1), (3.12) picoxystrobin (117428-22-5), (3.13) pyraclostrobin (175013-18-0), (3.14) pyrametostrobin (915410-70-7), (3.15) pyraoxystrobin (862588-11-2), (3.16) pyribencarb (799247-52-2), (3.17) trifloxystrobin (141517-21-7), (3.18) 5-methoxy-2-methyl-4-(2-{[({(1E)-1-[3-(trifluoromethyl)phenyl]ethylidene}amino)oxy]methyl}-phenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one, (3.19) (2E)-2-(2-{[6-(3-chloro-2-methylphenoxy)-5-fluoropyrimidin-4-yl]oxy}phenyl)-2-(methoxyimino)-N-methylethanamide, (3.20) 2-chloro-N-(1,1,3-trimethyl-2,3-dihydro-1H-inden-4-yl)pyridine-3-carboxamide (119899-14-8), (3.21) (2E)-2-(methoxyimino)-N-methyl-2-(2-{[({(1E)-1-[3-(trifluoromethyl)phenyl]ethylidene}amino)-oxy]methyl}phenyl)ethanamide, (3.22) N-(3-ethyl-3,5,5-trimethyl-cyclohexyl)-3-(formylamino)-2-hydroxybenzamide (226551-21-9), (3.23) (2E)-2-(methoxyimino)-N-methyl-2-{2-[(E)-({1-[3-(trifluoromethyl)-phenyl]ethoxy}imino)methyl]phenyl}ethanamide (326896-28-0), (3.24) (2E)-2-{2-[({[(2E,3E)-4-(2,6-dichlorophenyl)but-3-en-2-ylidene]amino}oxy)-methyl]phenyl}-2-(methoxyimino)-N-methylethanamide (known from WO 02/12172), (3.25) (2E)-2-{2-([{[(1E)-1-(3-{[(E)-1-fluoro-2-phenylethenyl]-oxy}phenyl)ethylidene]amino}oxy)methyl]phenyl}-2-(methoxyimino)-N-methylethanamide (326896-28-0), (3.26) methyl (2E)-2-{2-[({cyclopropyl-[(4-methoxyphenyl)imino]methyl}thio)methyl]phenyl}-3-methoxyacrylate (149601-03-6), (3.27) N-(3-ethyl-3,5,5-trimethylcyclohexyl)-3-(formylamino)-2-hydroxybenzamide (226551-21-9), (3.28) 2-{2-[(2,5-dimethylphenoxy)methyl]phenyl}-2-methoxy-N-methylacetamide (173662-97-0) and salts thereof,
  • (B-I.4) Inhibitors of the mitosis and cell division, for example (4.1) benomyl (17804-35-2), (4.2) carbendazim (10605-21-7), (4.3) diethofencarb (87130-20-9), (4.4) ethaboxam (162650-77-3), (4.5) fuberidazole (3878-19-1), (4.6) pencycuron (66063-05-6), (4.7) thiabendazole (148-79-8), (4.8) thiophanate-methyl (23564-05-8), (4.9) zoxamide (156052-68-5), (4.10) 5-chloro-7-(4-methylpiperidin-1-yl)-6-(2,4,6-trifluorophenyl)[1,2,4]triazolo[1,5-a]pyrimidine (214706-53-3), (4.11) chlorfenazole (3574-96-7), (4.12) thiophanate (23564-06-9), (4.13) 3-chloro-5-(6-chloropyridin-3-yl)-6-methyl-4-(2,4,6-trifluorophenyl)pyridazine (1002756-87-7) and salts thereof,
  • (B-I.5) Compounds capable to have a multisite action, like for example (5.1) bordeaux mixture (8011-63-0), (5.2) captafol (2425-06-1), (5.3) captan (133-06-2), (5.4) chlorothalonil (1897-45-6), (5.5) dichlofluanid (1085-98-9), (5.6) dithianon (3347-22-6), (5.7) dodine (2439-10-3), (5.8) ferbam (14484-64-1), (5.9) folpet (133-07-3), (5.10) guazatine (108173-90-6), (5.11) iminoctadine (13516-27-3), (5.12) iminoctadine triacetate (57520-17-9), (5.13) iminoctadine albesilate (169202-06-6), (5.14) copper oxide (1317-39-1), (5.15) copper oxychloride (1332-40-7), (5.16) copper hydroxide (20427-59-2), (5.17) copper sulfate (7758-98-7), (5.18) mancopper (53988-93-5), (5.19) mancozeb (2234562), (5.20) maneb (12427-38-2), (5.21) metiram (9006-42-2), (5.22) oxine-copper (10380-28-6), (5.23) propineb (12071-83-9), (5.24) sulphur and sulphur preparations including calcium polysulphide (7704-34-9), (5.25) thiram (137-26-8), (5.26) tolylfluanid (731-27-1), (5.27) zineb (12122-67-7), (5.28) ziram (137-30-4), (5.29) copper naphthenate (1338-02-9), (5.30) dodine free base, (5.31) fluorofolpet (719-96-0), (5.32) guazatine acetate, (5.33) metiram zinc (9006-42-2). (5.34) propamidine (104-32-5),
  • (B-I.6) Compounds capable to induce a host defence, like for example (6.1) acibenzolar-S-methyl (135158-54-2), (6.2) probenazole (27605-76-1), (6.3) tiadinil (223580-51-6),
  • (B-I.7) Inhibitors of the amino acid and/or protein biosynthesis, for example (7.1) andoprim (23951-85-1), (7.2) blasticidin-S (2079-00-7), (7.3) cyprodinil (121552-61-2), (7.4) kasugamycin (6980-18-3), (7.5) kasugamycin hydrochloride hydrate (19408-46-9), (7.6) mepanipyrim (110235-47-7), (7.7) pyrimethanil (53112-28-0),
  • (B-I.8) Inhibitors of the ATP production, for example (8.1) fentin acetate (900-95-8), (8.2) fentin hydroxide (76-87-9), (8.3) silthiofam (175217-20-6), (8.4) fentin chloride (639-58-7),
  • (B-I.9) Inhibitors of the cell wall synthesis, for example (9.1) benthiavalicarb (177406-68-7), (9.2) dimethomorph (110488-70-5), (9.3) flumorph (211867-47-9), (9.4) iprovalicarb (140923-17-7), (9.5) mandipropamid (374726-62-2), (9.6) polyoxins (11113-80-7), (9.7) polyoxorim (22976-86-9), (9.8) prothiocarb (19622-08-3), (9.9) validamycin A (37248-47-8), (9.10) valifenalate (283159-94-4; 283159-90-0), (9.11) N-[2-(4-{[3-(4-chlorophenyl)prop-2-yn-1-yl]oxy}-3-methoxyphenyl)ethyl]-N2-(methylsulfonyl)valinamide (220706-93-4),
  • (B-I.10) Inhibitors of the lipid and membrane synthesis, for example (10.1) biphenyl (92-52-4), (10.2) chlozolinate (84332-86-5), (10.3) edifenphos (17109-49-8), (10.4) etridiazole (2593-15-9), (10.5) iodocarb (55406-53-6), (10.6) iprobenfos (26087-47-8), (10.7) iprodione (36734-19-7), (10.8) isoprothiolane (50512-35-1), (10.9) procymidone (32809-16-8), (10.10) propamocarb (25606-41-1), (10.11) propamocarb hydrochloride (25606-41-1), (10.12) pyrazophos (13457-18-6), (10.13) tolclofos-methyl (57018-04-9), (10.14) vinclozolin (50471-44-8),
  • (B-I.11) Inhibitors of the melanine biosynthesis, for example (11.1) carpropamid (104030-54-8), (11.2) diclocymet (139920-32-4), (11.3) fenoxanil (115852-48-7), (11.4) phthalide (27355-22-2), (11.5) pyroquilon (57369-32-1), (11.6) tricyclazole (41814-78-2),
  • (B-I.12) Inhibitors of the nucleic acid synthesis, for example (12.1) benalaxyl (71626-11-4), (12.2) benalaxyl-M (98243-83-5), (12.3) bupirimate (41483-43-6), (12.4) clozylacon (67932-85-8), (12.5) dimethirimol (5221-53-4), (12.6) ethirimol (23947-60-6), (12.7) furalaxyl (57646-30-7), (12.8) hymexazol (10004-44-1), (12.9) metalaxyl (57837-19-1), (12.10) metalaxyl-M (70630-17-0), (12.11) ofurace (58810-48-3), (12.12) oxadixyl (77732-09-3), (12.13) oxolinic acid (14698-29-4),
  • (B-I.13) Inhibitors of the signal transduction, for example (13.1) fenpiclonil (74738-17-3), (13.2) fludioxonil (131341-86-1), (13.3) quinoxyfen (124495-18-7),
  • (B-I.14) Compounds capable to act as an uncoupler, like for example (14.1) dinocap (131-72-6), (14.2) fluazinam (79622-59-6), (14.3) meptyldinocap (131-72-6), (14.4) binapacryl (485-31-4),
  • (B-I.15) Further compounds like for example (15.1) ametoctradin (865318-97-4), (15.2) benthiazole (21564-17-0), (15.3) bethoxazin (163269-30-5), (15.4) carvone (99-49-0), (15.5) chinomethionat (2439-01-2), (15.6) cyflufenamid (180409-60-3), (15.7) cymoxanil (57966-95-7), (15.8) dazomet (533-74-4), (15.9) debacarb (62732-91-6), (15.10) dichlorophen (97-23-4), (15.11) diclomezine (62865-36-5), (15.12) dicloran (99-30-9), (15.13) difenzoquat (43222-48-6), (15.14) diphenylamine (122-39-4), (15.15) ferimzone (89269-64-7), (15.16) flumetover (154025-04-4), (15.17) fluopicolide (239110-15-7), (15.18) fluoroimide (41205-21-4), (15.19) flusulfamide (106917-52-6), (15.20) fosetyl-aluminium (39148-24-8), (15.21) hexachlorobenzene (118-74-1), (15.22) isotianil (224049-04-1), (15.23) methasulfocarb (66952-49-6), (15.24) methyl isothiocyanate (556-61-6), (15.25) metrafenone (220899-03-6), (15.26) nitrothal-isopropyl (10552-74-6), (15.27) octhilinone (26530-20-1), (15.28) oxyfenthiin (34407-87-9), (15.29) propamocarb-fosetylate, (15.30) proquinazid (189278-12-4), (15.31) pyrrolnitrine (1018-71-9), (15.32) quintozene (82-68-8), (15.33) tecloftalam (76280-91-6), (15.34) tecnazene (117-18-0), (15.35) triazoxide (72459-58-6), (15.36) trichlamide (70193-21-4), (15.37) zarilamid (84527-51-5), (15.38) quinolin-8-ol sulfate (2:1) (salt) (8-hydroxyquinoline sulfat) (134-31-6), (15.39) 2,3,5,6-tetrachloro-4-(methylsulfonyl)pyridine (13108-52-6), (15.40) 3,4,5-trichloropyridine-2,6-dicarbonitrile (17824-85-0), (15.41) 3-[5-(4-chlorophenyl)-2,3-dimethylisoxazolidin-3-yl]pyridine, (15.43) 2-butoxy-6-iodo-3-propyl-4H-chromen-4-one, (15.44) N-[1-(5-bromo-3-chloropyridin-2-yl)ethyl]-2,4-dichloropyridine-3-carboxamide, (15.45) N-[(5-bromo-3-chloropyridin-2-yl)methyl]-2,4-dichloropyridine-3-carboxamide, (15.46) N-[1-(5-bromo-3-chloropyridin-2-yl)ethyl]-2-fluoro-4-iodopyridine-3-carboxamide, (15.47) N-(4-chlorobenzyl)-3-[3-methoxy-4-(prop-2-yn-1-yloxy)phenyl]propanamide, (15.48) N-[(4-chlorophenyl)(cyano)methyl]-3-[3-methoxy-4-(prop-2-yn-1-yloxy)phenyl]propanamide, (15.49) S-prop-2-en-1-yl 5-amino-2-(1-methylethyl)-4-(2-methylphenyl)-3-oxo-2,3-dihydro-1H-pyrazole-1-carbothioate, (15.50) 2,3-dibutyl-6-chlorothieno[2,3-d]pyrimidin-4(3H)-one (221451-58-7), (15.51) ethyl (2Z)-3-amino-2-cyano-3-phenylprop-2-enoate, (15.52) 5-amino-1,3,4-thiadiazole-2-thiol, (15.53) 1-[(4-methoxy-phenoxy)methyl]-2,2-dimethylpropyl 1H-imidazole-1-carboxylate (111227-17-9), (15.54) 3-chloro-5-(4-chlorophenyl)-4-(2,6-difluorophenyl)-6-methylpyridazine, (15.55) 4-(4-chlorophenyl)-5-(2,6-difluorophenyl)-3,6-dimethylpyridazine, (15.56) tebufloquin (376645-78-2), (15.57) flutianil (304900-25-2), (15.58) (5-bromo-2-methoxy-4-methylpyridin-3-yl)(2,3,4-trimethoxy-6-methylphenyl)methanone (known from EP-A 1 559 320), (15.59) tolnifanide (304911-98-6), (15.60) N-{(Z)-[(cyclopropyl-methoxy)imino][6-(difluoromethoxy)-2,3-difluorophenyl]methyl}-2-phenylacetamide (221201-92-9), (15.61) N-{(E)-[(cyclopropylmethoxy)imino][6-(difluoromethoxy)-2,3-difluorophenyl]methyl}-2-phenylacetamide, (15.62) phosphorous acid and its salts (13598-36-2), (15.63) 5-chloro-N′-phenyl-N′-prop-2-yn-1-ylthiophene-2-sulfonohydrazide (134-31-6), (15.64) N-methyl-2-(1-{[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-N-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]-1,3-thiazole-4-carboxamide, (15.65) N-methyl-2-(1-{[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl}-piperidin-4-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1,3-thiazole-4-carboxamide, (15.66) pentyl {6-[({[(1-methyl-1H-tetrazol-5-yl)(phenyl)methyl-idene]amino}oxy)methyl]pyridin-2-yl}carbamate, (15.67) capsimycin (70694-08-5), (15.68) chloroneb (2675-77-6), (15.69) cufraneb (11096-18-7), (15.70) cyprosulfamide (221667-31-8), (15.71) difenzoquat methylsulphate (43222-48-6), (15.72) ecomate, (15.73) fosetyl-calcium, (15.74) fosetyl-sodium (39148-16-8), (15.75) irumamycin (81604-73-1), (15.76) mildiomycin (67527-71-3), (15.77) natamycin (7681-93-8), (15.78) nickel dimethyldithiocarbamate (15521-65-0), (15.79) oxamocarb (917242-12-7), (15.80) pentachlorophenol and salts (87-86-5), (15.81) phenazine-1-carboxylic acid, (15.82) phenothrin, (15.83) propanosine-sodium (88498-02-6), (15.84) quinolin-8-ol (134-31-6), (15.85) 2-phenylphenol and salts (90-43-7), (15.86) 5-methyl-6-octyl-3,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-7-amine, (15.87) 2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-1-(4-{4-[(5R)-5-phenyl-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl}piperidin-1-yl)ethanone, (15.88) 1-(4-{4-[(5R)-5-(2,6-difluorophenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl}piperidin-1-yl)-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]ethanone and salts thereof,
    or
• (B-II) at least one further insecticidally active compound, selected from the group consisting of
  • (B-II.1) Acetylcholinesterase (AChE) inhibitors, for example carbamates, e.g. alanycarb, aldicarb, bendiocarb, benfuracarb, butocarboxim, butoxycarboxim, carbaryl, carbofuran, carbosulfan, ethiofencarb, fenobucarb, formetanate, furathiocarb, isoprocarb, methiocarb, methomyl, metolcarb, oxamyl, pirimicarb, propoxur, thiodicarb, thiofanox, triazamate, trimethacarb, XMC, and xylylcarb; or organophosphates, e.g. acephate, azamethiphos, azinphos (-methyl, -ethyl), cadusafos, chlorethoxyfos, chlorfenvinphos, chlorfenvinphos, chlormephos, chlorpyrifos (-methyl), coumaphos, cyanophos, demeton-S-methyl, diazinon, dichlorvos/DDVP, dicrotophos, dimethoate, dimethylvinphos, disulfoton, EPN, ethion, ethoprophos, famphur, fenamiphos, fenitrothion, fenthion, fosthiazate, heptenophos, isofenphos, isopropyl O-(methoxyaminothio-phosphoryl) salicylate, isoxathion, malathion, mecarbam, methamidophos, methidathion, mevinphos, monocrotophos, naled, omethoate, oxydemeton-methyl, parathion (-methyl), phenthoate, phorate, phosalone, phosmet, phosphamidon, phoxim, pirimiphos (-methyl), profenofos, propetamphos, prothiofos, pyraclofos, pyridaphenthion, quinalphos, sulfotep, tebupirimfos, temephos, terbufos, tetrachlorvinphos, thiometon, triazophos, triclorfon, and vamidothion,
  • (B-II.2) GABA-gated chloride channel antagonists, for example organochlorines, e.g. chlordane, endosulfan (alpha-); or fiproles (phenylpyrazoles), e.g. ethiprole, fipronil, pyrafluprole, and pyriprole,
  • (B-II.3) Sodium channel modulators/voltage-dependent sodium channel blockers, for example pyrethroids, e.g. acrinathrin, allethrin (d-cis-trans, d-trans), bifenthrin, bioallethrin, bioallethrin S-cyclopentenyl, bioresmethrin, cycloprothrin, cyfluthrin (beta-), cyhalothrin (gamma-, lambda-), cypermethrin (alpha-, beta-, theta-, zeta-), cyphenothrin [(1R)-trans-isomers], deltamethrin, dimefluthrin, empenthrin [(EZ)-(1R)-isomers), esfenvalerate, etofenprox, fenpropathrin, fenvalerate, flucythrinate, flumethrin, fluvalinate (tau-), halfenprox, imiprothrin, metofluthrin, permethrin, phenothrin [(1R)-trans-isomer), prallethrin, profluthrin, pyrethrin (pyrethrum), resmethrin, RU 15525, silafluofen, tefluthrin, tetramethrin [(1R)-isomers)], tralomethrin, transfluthrin and ZXI 8901; or DDT; or methoxychlor,
  • (B-II.4) Nicotinergic acetylcholine receptor agonists, for example chloronicotinyls, e.g. acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam; or nicotine,
  • (B-II.5) Allosteric acetylcholine receptor modulators (agonists), for example spinosyns, e.g. spinetoram and spinosad,
  • (B-II.6) Chloride channel activators, for example_avermectins/milbemycins, e.g. abamectin, emamectin benzoate, lepimectin, and milbemectin,
  • (B-II.7) Juvenile hormone mimics, e.g. hydroprene, kinoprene, methoprene; or fenoxycarb; pyriproxyfen,
  • (B-II.8) Miscellaneous non-specific (multi-site) inhibitors, for example_gassing agents, e.g. methyl bromide and other alkyl halides; or chloropicrin; sulfuryl fluoride; borax; tartar emetic,
  • (B-II.9) Selective homopteran feeding blockers, e.g. pymetrozine or flonicamid,
  • (B-II.10) Mite growth inhibitors, e.g. clofentezine, diflovidazin, hexythiazox, etoxazole,
  • (B-II.11) Microbial disruptors of insect midgut membranes, e.g. Bacillus thuringiensis subspecies israelensis, Bacillus sphaericus, Bacillus thuringiensis subspecies aizawai, Bacillus thuringiensis subspecies kurstaki, Bacillus thuringiensis subspecies tenebrionis, and BT crop proteins: Cry1Ab, Cry1Ac, Cry1Fa, Cry2Ab, mCry3A, Cry3Ab, Cry3Bb, Cry34/35Ab1,
  • (B-II.12) Inhibitors of mitochondrial ATP synthase, for example diafenthiuron; or organotin miticides, e.g. azocyclotin, cyhexatin, and fenbutatin oxide; or propargite; tetradifon,
  • (B-II.13) Uncouplers of oxidative phoshorylation via disruption of the proton gradient, for example chlorfenapyr, and DNOC,
  • (B-II.14) Nicotinic acetylcholine receptor channel blockers, for example bensultap, cartap hydrochloride, thiocyclam, and thiosultap-sodium,
  • (B-II.15) Inhibitors of chitin biosynthesis, type 0, for example benzoylureas, e.g. bistrifluoron, chlorfluazuron, diflubenzuron, flucycloxuron, flufenoxuron, hexaflumuron, lufenuron, novaluron, noviflumuron, penfluoron, teflubenzuron, and triflumuron,
  • (B-II.16) Inhibitors of chitin biosynthesis, type 1, for example buprofezin,
  • (B-II.17) Moulting disruptors, for example cyromazine,
  • (B-II.18) Ecdysone receptor agonists/disruptors, for example diacylhydrazines, e.g. chromafenozide, halofenozide, methoxyfenozide, and tebufenozide,
  • (B-II.19) Octopamine receptor agonists, for example amitraz,
  • (B-II.20) Mitochondrial complex III electron transport inhibitors, for example hydramethylnon; acequinocyl or fluacrypyrim,
  • (B-II.21) Mitochondrial complex I electron transport inhibitors, for example METI acaricides, e.g. fenazaquin, fenpyroximate, pyrimidifen, pyridaben, tebufenpyrad, tolfenpyrad or rotenone (Derris),
  • (B-II.22) Voltage-dependent sodium channel blockers, e.g. indoxacarb; metaflumizone,
  • (B-II.23) Inhibitors of acetyl CoA carboxylase, for example tetronic acid derivatives, e.g. spirodiclofen and spiromesifen; or tetramic acid derivatives, e.g. spirotetramat,
  • (B-II.24) Mitochondrial complex IV electron inhibitors, for example phosphines, e.g. aluminium phosphide, calcium phosphide, phosphine, and zinc phosphide or cyanide,
  • (B-II.25) Mitochondrial complex II electron transport inhibitors, for example cyenopyrafen,
  • (B-II.28) Ryanodine receptor modulators, for example diamides, e.g. chlorantraniliprole (Rynaxypyr), Cyantraniliprole (Cyazypyr), and flubendiamide,
  • (B-II.29) Further active ingredients with unknown or uncertain mode of action, for example azadirachtin, amidoflumet, benzoximate, bifenazate, chinomethionat, cryolite, cyflumetofen, dicofol, flufenerim, pyridalyl, and pyrifluquinazon; or one of the following known active compounds 4-{[(6-brompyrid-3-yl)methyl](2-fluorethyl)amino}furan-2(5H)-on (known from WO 2007/115644), 4-{[(6-fluorpyrid-3-yl)methyl](2,2-difluorethyl)amino}-furan-2(5H)-on (known from WO 2007/115644), 4-{([(2-chlor-1,3-thiazol-5-yl)methyl](2-fluorethyl)amino}furan-2(5H)-on (known from WO 2007/115644), 4-{[(6-chlorpyrid-3-yl)methyl](2-fluorethyl)amino}furan-2(5H)-on (known from WO 2007/115644), 4-{[(6-chlorpyrid-3-yl)methyl](2,2-difluorethyl)amino}furan-2(5H)-on known from WO 2007/115644), 4-{[(6-chlor-5-fluorpyrid-3-yl)methyl](methyl)amino}furan-2(5H)-on (known from WO 2007/115643), 4-{[(5,6-dichlorpyrid-3-yl)methyl](2-fluorethyl)amino}furan-2(5H)-on (known from WO 2007/115646), 4-{[(6-chlor-5-fluorpyrid-3-yl)methyl](cyclopropyl)amino}-furan-2(5H)-on (known from WO 2007/115643), 4-{[(6-chlorpyrid-3-yl)methyl](cyclopropyl)amino}furan-2(5H)-on (known from EP-A-0 539 588), 4-{[(6-chlorpyrid-3-yl)methyl](methyl)amino}furan-2(5H)-on (known from EP-A-0 539 588), [(6-chlorpyridin-3-yl)methyl](methyl)oxido-λ⁴-sulfanylidencyanamid (known from WO 2007/149134), [1-(6-chlorpyridin-3-yl)ethyl](methyl)oxido-λ⁴-sulfanylidencyanamid (known from WO 2007/149134) and its diastereomeres (A) and (B)

• • (also known from WO 2007/149134), [(6-trifluormethylpyridin-3-yl)methyl](methyl)-oxido-λ⁴-sulfanylidencyanamid (known from WO 2007/095229), or sulfoxaflor (also known from WO 2007/149134), 11-(4-chloro-2,6-dimethylphenyl)-12-hydroxy-1,4-dioxa-9-azadispiro[4.2.4.2]tetradec-11-en-10-one (known from WO 2006/089633), 3-(4′-fluoro-2,4-dimethylbiphenyl-3-yl)-4-hydroxy-8-oxa-1-azaspiro[4.5]dec-3-en-2-one (known from WO 2008/067911), and 1-{2,4-dimethyl-5-[(2,2,2-trifluoroethyl)-sulfinyl]phenyl}-3-(trifluoromethyl)-1H-1,2,4-triazole (known from WO 1999/55668); fluensulfone (5-chloro-2-[(3,4,4-trifluorobut-3-en-1-yl)sulfonyl]-1,3-thiazole), 1-[2-fluoro-4-methyl-5-[(2,2,2-trifluoroethyl)sulfinyl]phenyl]-3-(trifluoromethyl)-1H-1,2,4-Triazol-5-amine (bekannt aus WO 2006/043635), [(3S,4aR,12R,12aS,12bS)-3-[(Cyclopropylcarbonyl)oxy]-6,12-dihydroxy-4,12b-dimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a,12b-decahydro-2H,11H-benzo[f]pyrano[4,3-b]chromen-4-yl]methylcyclopropancarboxylat (bekannt aus WO 2006/129714), 2-Cyan-3-(difluormethoxy)-N,N-dimethylbenzolsulfonamid (bekannt aus WO2006/056433), 2-Cyan-3-(difluormethoxy)-N-methylbenzolsulfonamid (bekannt aus WO2006/100288), 2-Cyan-3-(difluormethoxy)-N-ethylbenzolsulfonamid (bekannt aus WO2005/035486), 4-(Difluormethoxy)-N-ethyl-N-methyl-1,2-benzothiazol-3-amin-1,1-dioxid (bekannt aus WO2007/057407), N-[1-(2,3-Dimethylphenyl)-2-(3,5-dimethylphenyl)ethyl]-4,5-dihydro-1,3-thiazol-2-amin (bekannt aus WO2008/104503) furthermore products based on Bacillus firmus (I-1582, BioNeem, Votivo),
    or
• (B-III) at least one compound having plant growth regulating activity, selected from the group consisting of
  • (B-III.1) antiauxines for example clofibrin [2-(4-chlorophenoxy)-2-methylpropionic acid] and 2,3,5-tri-iodobenzoic acid,
  • (B-III.2) auxines, e.g. 4-CPA (4-chlorophenoxyacetic acid), 2,4-D (2,4-dichlorophenoxyacetic acid), 2,4-DB [4-(2,4-dichlorophenoxy)butyric acid], 2,4-DEP {tris[2-(2,4-dichlorophenoxy)ethyl]phosphite}, dichlorprop, fenoprop, IAA (β-indolacetic acid), IBA (4-indol-3-ylbutyric acid), naphthaleneacetamide, α-naphthaleneacetic acid, 1-naphthol, naphthoxyacetic acid, potassium naphthenate, sodium naphthenate, 2,4,5-T [(2,4,5-trichlorphenoxy)acetic acid],
  • (B-III.3) cytokinines, e.g. 2iP [N-(3-methylbut-2-enyl)-1H-purine-6-amine], benzyladenine, kinetin, zeatin,
  • (B-III.4) defoliating agents, for instance, calcium cyanamide, dimethipin, endothal, ethephon, merphos, metoxuron, pentachlorphenol, thidiazuron, tribufos,
  • (B-III.5) ethylene inhibitors, e.g. aviglycine, aviglycine-hydrochloride, 1-methylcyclopropen,
  • (B-III.6) ethylene generators, e.g. ACC (1-aminocyclopropancarboxylic acid), etacelasil, ethephon, glyoxime,
  • (B-III.7) gibberellines, such as gibberellines A1, A4, A7, gibberellinic acid (=gibberellin A3),
  • (B-III.8) further PGRs, such as abscisinic acid, ancymidol, butralin, carbaryl, chlorphonium or its chloride, chlorpropham, dikegulac, dikegulac-sodium, flumetralin, fluoridamide, fosamine, glyphosine, isopyrimol, jasmonic acid, maleic acid hydrazide or its potassium salt, mepiquat or its chloride, piproctanyl or its bromide, prohydrojasmon, propham, 2,3,5-tri-iodobenzoic acid, 2,6-diisopropylnaphthaline, cloprop, 1-naphthylacetic acid ethylester, isoprothiolane, MCPB-ethyl [4-(4-chloro-o-tolyloxy)butyric acid ethylester], N-acetylthiazolidine-4-carboxylic acid, n-decanol, pelargonic acid, N-phenylphthaliminic acid, tecnazene, triacontanol, 2,3-dihydro-5,6-diphenyl-1,4-oxathiin, 2-cyano-3-(2,4-dichlorophenyl)acrylic acid, 2-hydrazinoethanol, alorac, amidochlor, BTS 44584 [dimethyl(4-piperidinocarbonyloxy-2,5-xylyl)sulfonium-toluen-4-sulfonat], chloramben, chlorfluren, chlorfluren-methyl, dicamba-methyl, dichlorflurenol, dichlorflurenol-methyl, dimexano, etacelasil, hexafluoraceton-trihydrat, N-(2-ethyl-2H-pyrazol-3-yl)-N′-phenylurea, N-m-tolylphthalaminic acid, N-Pyrrolidinosuccinaminic acid, 3-tert-Butylphenoxyacetic acid propylester, pydanon, sodium (Z)-3-chloracrylate,
  • (B-III.9) morphactines, such as chlorfluren, chlorflurenol, chlorflurenol-methyl, dichlorflurenol, flurenol,
  • (B-III.10) plant growth retarder/modifier, such as chlormequat, chlormequat-chlorid, daminozide, flurprimidol, mefluidide, mefluidide-diolamin, paclobutrazol, cyproconazole, tetcyclacis, uniconazole, uniconazole-P,
  • (B-III.11) plant growth stimulators, such as brassinolides, forchlorfenuron, hymexazol, 2-amino-6-oxypurine derivatives, indolinon derivatives, 3,4-disubstituted maleimide derivatives and azepinon derivatives,
  • (B-III.12) non-classified PGRs, such as benzofluor, buminafos, carvone, ciobutide, clofencet, clofence-potassium, cloxyfonac, cloxyfonac-Natrium, cyclanilide, cycloheximide, epocholeone, ethychlozate, ethylene, fenridazon, heptopargil, holosulf, inabenfide, karetazan, leadarsenate, methasulfocarb, prohexadione, prohexadione-Calcium, pydanon, sintofen, triapenthenol, trinexapac and trinexapac-ethyl.

Preference is given to combinations comprising compounds of the formula (I), wherein the amidine derivatives are represented by the following formula (Ia):

Preference is further given to combinations comprising a compound (B-I) selected from the list consisting of Cyproconazole, Epoxiconazole, Flusilazole, Fluquinconazole Ipconazole, Propiconazole, Prothioconazole, Metconazole, Tebuconazole, Triadimenol, Azoxystrobin, Fluoxastrobin, Kresoxim-methyl, Picoxystrobin, Pyraclostrobin, Trifloxystrobin, Boscalid, Chlorothalonil, Cyprodinil, Fludioxonil, Fluopyram, Thiophanat-methyl, Penflufen, Isopyrazam, Sedaxane, Myclobutonil, Prochloraz, Spiroxamine, N-(3′,4′-dichloro-5-fluoro[1,1′-biphenyl]-2-yl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide, Ametoctradin, 5-Chlor-6-(2,4,6-trifluorphenyl)-7-(4-methylpiperidin-1-yl)[1,2,4]triazolo[1,5-a]pyrimidin, 1-methyl-N-{2-[1′-methyl-1,1′-bi(cyclopropyl)-2-yl]phenyl}-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide, 1-methyl-N-{2-[1′-methyl-1,1′-bi(cyclopropyl)-2-yl]phenyl}-3-(difluoro-methyl)-1H-pyrazole-4-carboxamide, N-{2-[1,1′-bi(cyclopropyl)-2-yl]phenyl}-1-methyl-3-(difluoromethyl)-1H-pyrazole-4-carboxamide.

Preference is further given to combinations comprising an insecticidally active compound (B-II) selected from the list consisting of Acephate, Acequinocyl, Acrinathrin, Aldicarb, Amitraz, Anthraquinone, Azinphos-Methyl, Azocyclotin, Bendiocarb, Benfuracarb, Bifenthrin, Buprofezin, Carbaryl, Carbofuran, Carbosulfan, Cartap, Chlorfluazuron, Chlorpyrifos, Chlorpyrifos-M, Clofentezine, Clothianidin, Cyfluthrin, Cyhexatin, Cypermethrin, Cyromazine, Deltamethrin, Diazinon, Dichloropropene, Dichlorvos, Dimethoate, Disulfoton, Ethion, Ethiprole, Ethoprophos, Etofenprox, Fenamiphos, Fenitrothion, Fenobucarb, Fenpyroximate, Fenthion, Fipronil, Flubendiamide, Formetanate, Heptenophos, Hexythiazox, Imidacloprid, Metaldehyde, Methamidophos, Methiocarb, Methomyl, Methoxyfenozide, Milbemectin, M-Isothiocyanate, Permethrin, Phenthoate, Phosalone, Phoxim, Polyeder-Nuclear-Vir, Profenofos, Propargite, Prothiofos, Pyrethroids, Pyriproxifen, Quinalphos, Quinomethionate, Resmethrin, Silafluofen, Sodium-Tetrathiocarbonate, Spinosad, Spirodiclofen, Spiromesifen, Spirotetramat, Tebupirimphos, Tefluthrin, Thiacloprid, Thiamethoxam, Thiodicarb, Triazophos, Trichlorfon, Triflumuron.

Preference is further given to combinations comprising a compound (B-III) selected from the list consisting of chlormequat, chlormequat-chloride, cyclanilide, dimethipin, ethephon, flumetralin, flurprimidol, inabenfide, mepiquat, mepiquat-chlorid, 1-methylcyclopropen, paclobutrazol, prohexadione-calcium, prohydrojasmon, tribufos, thidiazuron, trinexapac, trinexapac-ethyl and uniconazol.

Particular preference is given to combinations comprising an active compound (B-I) selected from the list consisting of Prothioconazole, Tebuconazole, Metconazole, Epoxiconazole, Fluquinconazole, Prochloraz, Carbendazim, Thiophanat-methyl, Myclobutanil, Dimoxystrobin, Fluopyram, Fludioxonil.

Particular preference is given to combinations comprising an active compound (B-III) selected from the list consisting of trinexapac-ethyl, chlormequat-chloride and paclobutrazole.

For most of the compounds of group (B-I) to (B-III) it is referred to The Pesticide Manual, 15^th edition, 2009. The compounds (B) are listed by common names followed by the corresponding CAS-numbers in parenthesis. If no common name was available at the priority date of the application compounds (B) are listed by IUPAC-names followed by the corresponding CAS-numbers in parenthesis.

Particularly preferred combinations and or compositions comprise the amidine of formula (Ia) and at least one compound of group (B-I), which is selected from the group consisting of (1.1) aldimorph (1704-28-5), (1.2) azaconazole (60207-31-0), (1.3) bitertanol (55179-31-2), (1.4) bromuconazole (116255-48-2), (1.5) cyproconazole (113096-99-4), (1.6) diclobutrazole (75736-33-3), (1.7) difenoconazole (119446-68-3), (1.8) diniconazole (83657-24-3), (1.9) diniconazole-M (83657-18-5), (1.10) dodemorph (1593-77-7), (1.11) dodemorph acetate (31717-87-0), (1.12) epoxiconazole (106325-08-0), (1.13) etaconazole (60207-93-4), (1.14) fenarimol (60168-88-9), (1.15) fenbuconazole (114369-43-6), (1.16) fenhexamid (126833-17-8), (1.17) fenpropidin (67306-00-7), (1.18) fenpropimorph (67306-03-0), (1.19) fluquinconazole (136426-54-5), (1.20) flurprimidol (56425-91-3), (1.21) flusilazole (85509-19-9), (1.22) flutriafol (76674-21-0), (1.23) furconazole (112839-33-5), (1.24) furconazole-cis (112839-32-4), (1.25) hexaconazole (79983-71-4), (1.26) imazalil (60534-80-7), (1.27) imazalil sulfate (58594-72-2), (1.28) imibenconazole (86598-92-7), (1.29) ipconazole (125225-28-7), (1.30) metconazole (125116-23-6), (1.31) myclobutanil (88671-89-0), (1.32) naftifine (65472-88-0), (1.33) nuarimol (63284-71-9), (1.34) oxpoconazole (174212-12-5), (1.35) paclobutrazol (76738-62-0), (1.36) pefurazoate (101903-30-4), (1.37) penconazole (66246-88-6), (1.38) piperalin (3478-94-2), (1.39) prochloraz (67747-09-5), (1.40) propiconazole (60207-90-1), (1.41) prothioconazole (178928-70-6), (1.42) pyributicarb (88678-67-5), (1.43) pyrifenox (88283-41-4), (1.44) quinconazole (103970-75-8), (1.45) simeconazole (149508-90-7), (1.46) spiroxamine (118134-30-8), (1.47) tebuconazole (107534-96-3), (1.48) terbinafine (91161-71-6), (1.49) tetraconazole (112281-77-3), (1.50) triadimefon (43121-43-3), (1.51) triadimenol (89482-17-7), (1.52) tridemorph (81412-43-3), (1.53) triflumizole (68694-11-1), (1.54) triforine (26644-46-2), (1.55) triticonazole (131983-72-7), (1.56) uniconazole (83657-22-1), (1.57) viniconazole (77174-66-4), (1.58) 1-(4-chlorophenyl)-2-(1H-1,2,4-triazol-1-yl)cycloheptanol (129586-32-9), (1.59) methyl 1-(2,2-dimethyl-2,3-dihydro-1H-inden-1-yl)-1H-imidazole-5-carboxylate (111323-95-0), (1.60) O-{1-[(4-methoxyphenoxy)methyl]-2,2-dimethylpropyl}1H-imidazole-1-carbothioate (111226-71-2), (1.61) N′-{5-(difluoromethyl)-2-methyl-4-[3-(trimethylsilyl)-propoxy]phenyl}-N-ethyl-N-methylimidoformamide, (1.62) N-ethyl-N-methyl-N′-{2-methyl-5-(trifluoromethyl)-4-[3-(trimethylsilyl)propoxy]phenyl}imidoformamide, (1.63) voriconazole (137234-62-9); (2.1) diflumetorim (130339-07-0), (2.2) bixafen (581809-46-03), (2.3) boscalid (188425-85-6), (2.4) carboxin (5234-68-4), (2.5) fenfuram (24691-80-3), (2.6) fluopyram (658066-35-4), (2.7) flutolanil (66332-96-5), (2.8) furametpyr (123572-88-3), (2.9) furmecyclox (60568-05-0), (2.10) isopyrazam (mixture of syn-epimeric racemate 1RS,4SR,9RS and anti-epimeric racemate 1RS,4SR,9SR) (88165-58-1), (2.11) isopyrazam (syn epimeric racemate 1RS,4SR,9RS), (2.12) isopyrazam (syn-epimeric enantiomer 1R,4S,9R), (2.13) isopyrazam (syn-epimeric enantiomer 1S,4R,9S), (2.14) isopyrazam (anti-epimeric racemate 1RS,4SR,9SR), (2.15) isopyrazam (anti-epimeric enantiomer 1R,4S,9S), (2.16) isopyrazam (anti-epimeric enantiomer 1S,4R,9R), (2.17) mepronil (55814-41-0), (2.18) oxycarboxin (5259-88-1), (2.19) penflufen (494793-67-8), (2.20) penthiopyrad (183675-82-3), (2.21) sedaxane (874967-67-6), (2.22) thifluzamide (130000-40-7), (2.23) 1-methyl-N-[2-(1,1,2,2-tetrafluoroethoxy)phenyl]-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide, (2.24) 3-(difluoro-methyl)-1-methyl-N-[2-(1,1,2,2-tetrafluoroethoxy)phenyl]-1H-pyrazole-4-carboxamide, (2.25) 3-(difluoromethyl)-N-[4-fluoro-2-(1,1,2,3,3,3-hexafluoropropoxy)phenyl]-1-methyl-1H-pyrazole-4-carboxamide, (2.26) 1-methyl-3-(trifluoromethyl)-N-[2′-(trifluoromethyl)biphenyl-2-yl]-1H-pyrazole-4-carboxamide, (2.27) N-(4′-chlorobiphenyl-2-yl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide, (2.28) N-(2′,4′-dichlorobiphenyl-2-yl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide, (2.29) 3-(difluoromethyl)-1-methyl-N-[4′-(trifluoromethyl)biphenyl-2-yl]-1H-pyrazole-4-carboxamide, (2.30) N-(2′,5′-difluorobiphenyl-2-yl)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide, (2.31) 3-(difluoromethyl)-1-methyl-N-[4′-(prop-1-yn-1-yl)biphenyl-2-yl]-1H-pyrazole-4-carboxamide (known from WO 2004/058723), (2.32) 5-fluoro-1,3-dimethyl-N-[4′-(prop-1-yn-1-yl)biphenyl-2-yl]-1H-pyrazole-4-carboxamide (known from WO 2004/058723), (2.33) 2-chloro-N-[4′-(prop-1-yn-1-yl)biphenyl-2-yl]pyridine-3-carboxamide (known from WO 2004/058723), (2.34) 3-(difluoromethyl)-N-[4′-(3,3-dimethylbut-1-yn-1-yl)biphenyl-2-yl]-1-methyl-1H-pyrazole-4-carboxamide (known from WO 2004/058723), (2.35) N-[4′-(3,3-dimethylbut-1-yn-1-yl)biphenyl-2-yl]-5-fluoro-1,3-dimethyl-1H-pyrazole-4-carboxamide (known from WO 2004/058723), (2.36) 3-(difluoromethyl)-N-(4′-ethynylbiphenyl-2-yl)-1-methyl-1H-pyrazole-4-carboxamide (known from WO 2004/058723), (2.37) N-(4′-ethynylbiphenyl-2-yl)-5-fluoro-1,3-dimethyl-1H-pyrazole-4-carboxamide (known from WO 2004/058723), (2.38) 2-chloro-N-(4′-ethynylbiphenyl-2-yl)pyridine-3-carboxamide (known from WO 2004/058723), (2.39) 2-chloro-N-[4′-(3,3-dimethylbut-1-yn-1-yl)biphenyl-2-yl]pyridine-3-carboxamide (known from WO 2004/058723), (2.40) 4-(difluoromethyl)-2-methyl-N-[4′-(trifluoromethyl)biphenyl-2-yl]-1,3-thiazole-5-carboxamide (known from WO 2004/058723), (2.41) 5-fluoro-N-[4′-(3-hydroxy-3-methylbut-1-yn-1-yl)biphenyl-2-yl]-1,3-dimethyl-1H-pyrazole-4-carboxamide (known from WO 2004/058723), (2.42) 2-chloro-N-[4′-(3-hydroxy-3-methylbut-1-yn-1-yl)biphenyl-2-yl]pyridine-3-carboxamide (known from WO 2004/058723), (2.43) 3-(difluoromethyl)-N-[4′-(3-methoxy-3-methylbut-1-yn-1-yl)biphenyl-2-yl]-1-methyl-1H-pyrazole-4-carboxamide (known from WO 2004/058723), (2.44) 5-fluoro-N-[4′-(3-methoxy-3-methylbut-1-yn-1-yl)biphenyl-2-yl]-1,3-dimethyl-1H-pyrazole-4-carboxamide (known from WO 2004/058723), (2.45) 3-(difluoromethyl)-1-methyl-N-(3′,4′,5′-trifluorobiphenyl-2-yl)-1H-pyrazole-4-carboxamide, (2.46) 2-chloro-N-[4′-(3-methoxy-3-methylbut-1-yn-1-yl)biphenyl-2-yl]pyridine-3-carboxamide (known from WO 2004/058723), (3.1) amisulbrom (348635-87-0), (3.2) azoxystrobin (131860-33-8), (3.3) cyazofamid (120116-88-3), (3.4) dimoxystrobin (141600-52-4), (3.5) enestroburin (238410-11-2), (3.6) famoxadone (131807-57-3), (3.7) fenamidone (161326-34-7), (3.8) fluoxastrobin (361377-29-9), (3.9) kresoxim-methyl (143390-89-0), (3.10) metominostrobin (133408-50-1), (3.11) orysastrobin (189892-69-1), (3.12) picoxystrobin (117428-22-5), (3.13) pyraclostrobin (175013-18-0), (3.14) pyrametostrobin (915410-70-7), (3.15) pyraoxystrobin (862588-11-2), (3.16) pyribencarb (799247-52-2), (3.17) trifloxystrobin (141517-21-7), (3.18) 5-methoxy-2-methyl-4-(2-{[({(1E)-1-[3-(trifluoromethyl)phenyl]ethylidene}amino)oxy]-methyl}phenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one, (3.19) (2E)-2-(2-{[6-(3-chloro-2-methylphenoxy)-5-fluoropyrimidin-4-yl]oxy}phenyl)-2-(methoxyimino)-N-methylethanamide, (3.20) 2-chloro-N-(1,1,3-trimethyl-2,3-dihydro-1H-inden-4-yl)pyridine-3-carboxamide (119899-14-8), (3.21) (2E)-2-(methoxyimino)-N-methyl-2-(2-{[({(1E)-1-[3-(trifluoromethyl)-phenyl]ethylidene}amino)oxy]methyl}phenyl)ethanamide, (3.22) N-(3-ethyl-3,5,5-trimethyl-cyclohexyl)-3-(formylamino)-2-hydroxybenzamide (226551-21-9), (3.23) (2E)-2-(methoxyimino)-N-methyl-2-{2-[(E)-({1-[3-(trifluoromethyl)phenyl]ethoxy}imino)methyl]-phenyl}ethanamide (326896-28-0), (3.24) (2E)-2-{2-[({[(2E,3E)-4-(2,6-dichlorophenyl)but-3-en-2-ylidene]amino}oxy)methyl]phenyl}-2-(methoxyimino)-N-methylethanamide (known from WO 02/12172), (3.25) (2E)-2-{2-[({[(1E)-1-(3-{[(E)-1-fluoro-2-phenylethenyl]oxy}phenyl)ethylidene]amino}oxy)methyl]phenyl}-2-methoxyimino)-N-methylethanamide (326896-28-0), (3.26) methyl (2E)-2-{2-[({cyclopropyl[(4-methoxyphenyl)imino]methyl}thio)methyl]phenyl}-3-methoxyacrylate (149601-03-6), (3.27) N-(3-ethyl-3,5,5-trimethylcyclohexyl)-3-(formylamino)-2-hydroxybenzamide (226551-21-9), (3.28) 2-{2-[(2,5-dimethylphenoxy)methyl]phenyl}-2-methoxy-N-methylacetamide (173662-97-0), (4.1) benomyl (17804-35-2), (4.2) carbendazim (10605-21-7), (4.3) diethofencarb (87130-20-9), (4.4) ethaboxam (162650-77-3), (4.5) fuberidazole (3878-19-1), (4.6) pencycuron (66063-05-6), (4.7) thiabendazole (148-79-8), (4.8) thiophanate-methyl (23564-05-8), (4.9) zoxamide (156052-68-5), (4.10) 5-chloro-7-(4-methylpiperidin-1-yl)-6-(2,4,6-trifluorophenyl)[1,2,4]triazolo[1,5-a]pyrimidine (214706-53-3), (4.11) chlorfenazole (3574-96-7), (4.12) thiophanate (23564-06-9); (4.13) 3-chloro-5-(6-chloropyridin-3-yl)-6-methyl-4-(2,4,6-trifluorophenyl)pyridazine (1002756-87-7), (5.1) bordeaux mixture (8011-63-0), (5.2) captafol (2425-06-1), (5.3) captan (133-06-2), (5.4) chlorothalonil (1897-45-6), (5.5) dichlofluanid (1085-98-9), (5.6) dithianon (3347-22-6), (5.7) dodine (2439-10-3), (5.8) ferbam (14484-64-1), (5.9) folpet (133-07-3), (5.10) guazatine (108173-90-6), (5.11) iminoctadine (13516-27-3), (5.12) iminoctadine triacetate (57520-17-9), (5.13) iminoctadine albesilate (169202-06-6), (5.14) copper oxide (1317-39-1), (5.15) copper oxychloride (1332-40-7), (5.16) copper hydroxide (20427-59-2), (5.17) copper sulfate (7758-98-7), (5.18) mancopper (53988-93-5), (5.19) mancozeb (2234562), (5.20) maneb (12427-38-2), (5.21) metiram (9006-42-2), (5.22) oxine-copper (10380-28-6), (5.23) propineb (12071-83-9), (5.24) sulphur and sulphur preparations including calcium polysulphide (7704-34-9), (5.25) thiram (137-26-8), (5.26) tolylfluanid (731-27-1), (5.27) zineb (12122-67-7), (5.28) ziram (137-30-4), (5.29) copper naphthenate (1338-02-9), (5.30) dodine free base, (5.31) fluorofolpet (719-96-0), (5.32) guazatine acetate, (5.33) metiram zinc (9006-42-2). (5.34) propamidine (104-32-5); (6.1) acibenzolar-S-methyl (135158-54-2), (6.2) probenazole (27605-76-1), (6.3) tiadinil (223580-51-6); (7.1) andoprim (23951-85-1), (7.2) blasticidin-S (2079-00-7), (7.3) cyprodinil (121552-61-2), (7.4) kasugamycin (6980-18-3), (7.5) kasugamycin hydrochloride hydrate (19408-46-9), (7.6) mepanipyrim (110235-47-7), (7.7) pyrimethanil (53112-28-0); (8.1) fentin acetate (900-95-8), (8.2) fentin hydroxide (76-87-9), (8.3) silthiofam (175217-20-6), (8.4) fentin chloride (639-58-7); (9.1) benthiavalicarb (177406-68-7), (9.2) dimethomorph (110488-70-5), (9.3) flumorph (211867-47-9), (9.4) iprovalicarb (140923-17-7), (9.5) mandipropamid (374726-62-2), (9.6) polyoxins (11113-80-7), (9.7) polyoxorim (22976-86-9), (9.8) prothiocarb (19622-08-3), (9.9) validamycin A (37248-47-8), (9.10) valifenalate (283159-94-4; 283159-90-0), (9.11) N-[2-(4-{[3-(4-chlorophenyl)prop-2-yn-1-yl]oxy}-3-methoxyphenyl)ethyl]-N2-(methylsulfonyl)valinamide (220706-93-4); (10.1) biphenyl (92-52-4), (10.2) chlozolinate (84332-86-5), (10.3) edifenphos (17109-49-8), (10.4) etridiazole (2593-15-9), (10.5) iodocarb (55406-53-6), (10.6) iprobenfos (26087-47-8), (10.7) iprodione (36734-19-7), (10.8) isoprothiolane (50512-35-1), (10.9) procymidone (32809-16-8), (10.10) propamocarb (25606-41-1), (10.11) propamocarb hydrochloride (25606-41-1), (10.12) pyrazophos (13457-18-6), (10.13) tolclofos-methyl (57018-04-9), (10.14) vinclozolin (50471-44-8); (11.1) carpropamid (104030-54-8), (11.2) diclocymet (139920-32-4), (11.3) fenoxanil (115852-48-7), (11.4) phthalide (27355-22-2), (11.5) pyroquilon (57369-32-1), (11.6) tricyclazole (41814-78-2); (12.1) benalaxyl (71626-11-4), (12.2) benalaxyl-M (98243-83-5), (12.3) bupirimate (41483-43-6), (12.4) clozylacon (67932-85-8), (12.5) dimethirimol (5221-53-4), (12.6) ethirimol (23947-60-6), (12.7) furalaxyl (57646-30-7), (12.8) hymexazol (10004-44-1), (12.9) metalaxyl (57837-19-1), (12.10) metalaxyl-M (70630-17-0), (12.11) ofurace (58810-48-3), (12.12) oxadixyl (77732-09-3), (12.13) oxolinic acid (14698-29-4); (13.1) fenpiclonil (74738-17-3), (13.2) fludioxonil (131341-86-1), (13.3) quinoxyfen (124495-18-7); (14.1) dinocap (131-72-6), (14.2) fluazinam (79622-59-6), (14.3) meptyldinocap (131-72-6), (14.4) binapacryl (485-31-4); (15) Further compounds like for example (15.1) ametoctradin (865318-97-4), (15.2) benthiazole (21564-17-0), (15.3) bethoxazin (163269-30-5), (15.4) carvone (99-49-0), (15.5) chinomethionat (2439-01-2), (15.6) cyflufenamid (180409-60-3), (15.7) cymoxanil (57966-95-7), (15.8) dazomet (533-74-4), (15.9) debacarb (62732-91-6), (15.10) dichlorophen (97-23-4), (15.11) diclomezine (62865-36-5), (15.12) dicloran (99-30-9), (15.13) difenzoquat (43222-48-6), (15.14) diphenylamine (122-39-4), (15.15) ferimzone (89269-64-7), (15.16) flumetover (154025-04-4), (15.17) fluopicolide (239110-15-7), (15.18) fluoroimide (41205-21-4), (15.19) flusulfamide (106917-52-6), (15.20) fosetyl-aluminium (39148-24-8), (15.21) hexachlorobenzene (118-74-1), (15.22) isotianil (224049-04-1), (15.23) methasulfocarb (66952-49-6), (15.24) methyl isothiocyanate (556-61-6), (15.25) metrafenone (220899-03-6), (15.26) nitrothal-isopropyl (10552-74-6), (15.27) octhilinone (26530-20-1), (15.28) oxyfenthiin (34407-87-9), (15.29) propamocarb-fosetylate, (15.30) proquinazid (189278-12-4), (15.31) pyrrolnitrine (1018-71-9), (15.32) quintozene (82-68-8), (1533) tecloftalam (76280-91-6), (15.34) tecnazene (117-18-0), (15.35) triazoxide (72459-58-6), (15.36) trichlamide (70193-21-4), (15.37) zarilamid (84527-51-5), (15.38) quinolin-8-ol sulfate (2:1) (salt) (8-hydroxyquinoline sulfat) (134-31-6), (15.39) 2,3,5,6-tetrachloro-4-(methylsulfonyl)pyridine (13108-52-6), (15.40) 3,4,5-trichloropyridine-2,6-dicarbonitrile (17824-85-0), (15.41) 3-[5-(4-chlorophenyl)-2,3-dimethylisoxazolidin-3-yl]pyridine, (15.43) 2-butoxy-6-iodo-3-propyl-4H-chromen-4-one, (15.44) N-[1-(5-bromo-3-chloropyridin-2-yl)ethyl]-2,4-dichloropyridine-3-carboxamide, (15.45) N-[(5-bromo-3-chloropyridin-2-yl)methyl]-2,4-dichloropyridine-3-carboxamide, (15.46) N-[1-(5-bromo-3-chloropyridin-2-yl)ethyl]-2-fluoro-4-iodopyridine-3-carboxamide, (15.47) N-(4-chlorobenzyl)-3-[3-methoxy-4-(prop-2-yn-1-yloxy)phenyl]propanamide, (15.48) N-[(4-chlorophenyl)(cyano)methyl]-3-[3-methoxy-4-(prop-2-yn-1-yloxy)phenyl]propanamide, (15.49) S-prop-2-en-1-yl 5-amino-2-(1-methylethyl)-4-(2-methylphenyl)-3-oxo-2,3-dihydro-1H-pyrazole-1-carbothioate, (15.50) 2,3-dibutyl-6-chlorothieno[2,3-d]pyrimidin-4(3H)-one (221451-58-7), (15.51) ethyl (2Z)-3-amino-2-cyano-3-phenylprop-2-enoate, (15.52) 5-amino-1,3,4-thiadiazole-2-thiol, (15.53) 1-[(4-methoxyphenoxy)methyl]-2,2-dimethylpropyl 1H-imidazole-1-carboxylate (111227-17-9), (15.54) 3-chloro-5-(4-chlorophenyl)-4-(2,6-difluorophenyl)-6-methylpyridazine, (15.55) 4-(4-chlorophenyl)-5-(2,6-difluorophenyl)-3,6-dimethylpyridazine, (15.56) tebufloquin (376645-78-2), (15.57) flutianil (304900-25-2), (15.58) (5-bromo-2-methoxy-4-methylpyridin-3-yl)(2,3,4-trimethoxy-6-methylphenyl)methanone (known from EP-A 1 559 320), (15.59) tolnifanide (304911-98-6), (15.60) N-{(Z)-[(cyclopropylmethoxy)imino][6-(difluoromethoxy)-2,3-difluorophenyl]methyl}-2-phenylacetamide (221201-92-9), (15.61) N-{(E)-[(cyclopropylmethoxy)imino][6-(difluoromethoxy)-2,3-difluorophenyl]methyl}-2-phenylacetamide, (15.62) phosphorous acid and its salts (13598-36-2), (15.63) 5-chloro-N′-phenyl-N′-prop-2-yn-1-ylthiophene-2-sulfonohydrazide (134-31-6), (15.64) N-methyl-2-(1-{[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-N-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]-1,3-thiazole-4-carboxamide, (15.65) N-methyl-2-(1-{[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl}piperidin-4-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1,3-thiazole-4-carboxamide, (15.66) pentyl {6-[({[(1-methyl-1H-tetrazol-5-yl)(phenyl)methylidene]amino}-oxy)methyl]pyridin-2-yl}carbamate, (15.67) capsimycin (70694-08-5), (15.68) chloroneb (2675-77-6), (15.69) cufraneb (11096-18-7), (15.70) cyprosulfamide (221667-31-8), (15.71) difenzoquat methylsulphate (43222-48-6), (15.72) ecomate, (15.73) fosetyl-calcium, (15.74) fosetyl-sodium (39148-16-8), (15.75) irumamycin (81604-73-1), (15.76) mildiomycin (67527-71-3), (15.77) natamycin (7681-93-8), (15.78) nickel dimethyldithiocarbamate (15521-65-0), (15.79) oxamocarb (917242-12-7), (15.80) pentachlorophenol and salts (87-86-5), (15.81) phenazine-1-carboxylic acid, (15.82) phenothrin, (15.83) propanosine-sodium (88498-02-6), (15.84) quinolin-8-ol (134-31-6), (15.85) 2-phenylphenol and salts (90-43-7), (15.86) 5-methyl-6-octyl-3,7-dihydro[1,2,4]triazolo[1,5-a]pyrimidin-7-amine, (15.87) 2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-1-(4-{4-[(5R)-5-phenyl-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl}piperidin-1-yl)ethanone, (15.88) 1-(4-{4-[(5R)-5-(2,6-difluorophenyl)-4,5-dihydro-1,2-oxazol-3-yl]-1,3-thiazol-2-yl}piperidin-1-yl)-2-[5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]-ethanone and salts thereof.

Particularly preferred combinations and or compositions comprise the amidine of formula (Ia) and at least one insecticidally active compound of group (B-II), which is selected from the group consisting of alanycarb, aldicarb, bendiocarb, benfuracarb, butocarboxim, butoxycarboxim, carbaryl, carbofuran, carbosulfan, ethiofencarb, fenobucarb, formetanate, furathiocarb, isoprocarb, methiocarb, methomyl, metolcarb, oxamyl, pirimicarb, propoxur, thiodicarb, thiofanox, triazamate, trimethacarb, XMC, and xylylcarb; acephate, azamethiphos, azinphos (-methyl, -ethyl), cadusafos, chlorethoxyfos, chlorfenvinphos, chlorfenvinphos, chlormephos, chlorpyrifos (-methyl), coumaphos, cyanophos, demeton-S-methyl, diazinon, dichlorvos/DDVP, dicrotophos, dimethoate, dimethylvinphos, disulfoton, EPN, ethion, ethoprophos, famphur, fenamiphos, fenitrothion, fenthion, fosthiazate, heptenophos, isofenphos, isopropyl O-(methoxyaminothio-phosphoryl) salicylate, isoxathion, malathion, mecarbam, methamidophos, methidathion, mevinphos, monocrotophos, naled, omethoate, oxydemeton-methyl, parathion (-methyl), phenthoate, phorate, phosalone, phosmet, phosphamidon, phoxim, pirimiphos (-methyl), profenofos, propetamphos, prothiofos, pyraclofos, pyridaphenthion, quinalphos, sulfotep, tebupirimfos, temephos, terbufos, tetrachlorvinphos, thiometon, triazophos, triclorfon, and vamidothion, chlordane, endosulfan (alpha-); or fiproles (phenylpyrazoles), e.g. ethiprole, fipronil, pyrafluprole, and pyriprole, acrinathrin, allethrin (d-cis-trans, d-trans), bifenthrin, bioallethrin, bioallethrin S-cyclopentenyl, bioresmethrin, cycloprothrin, cyfluthrin (beta-), cyhalothrin (gamma-, lambda-), cypermethrin (alpha-, beta-, theta-, zeta-), cyphenothrin [(1R)-trans-isomers], deltamethrin, dimefluthrin, empenthrin [(EZ)-(1R)-isomers), esfenvalerate, etofenprox, fenpropathrin, fenvalerate, flucythrinate, flumethrin, fluvalinate (tau-), halfenprox, imiprothrin, metofluthrin, permethrin, phenothrin [(1R)-trans-isomer), prallethrin, profluthrin, pyrethrin (pyrethrum), resmethrin, RU 15525, silafluofen, tefluthrin, tetramethrin [(1R)-isomers)], tralomethrin, transfluthrin and ZXI 8901; or DDT; or methoxychlor, chloronicotinyls, e.g. acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam; or nicotine, spinetoram and spinosad, abamectin, emamectin benzoate, lepimectin, and milbemectin, hydroprene, kinoprene, methoprene; or fenoxycarb; pyriproxyfen, methyl bromide and other alkyl halides, chloropicrin; sulfuryl fluoride; borax; tartar emetic, pymetrozine or flonicamid, clofentezine, diflovidazin, hexythiazox, etoxazole, Bacillus thuringiensis subspecies israelensis, Bacillus sphaericus, Bacillus thuringiensis subspecies aizawai, Bacillus thuringiensis subspecies kurstaki, Bacillus thuringiensis subspecies tenebrionis, and BT crop proteins: Cry1Ab, Cry1Ac, Cry1Fa, Cry2Ab, mCry3A, Cry3Ab, Cry3Bb, Cry34/35Ab1, diafenthiuron; azocyclotin, cyhexatin, and fenbutatin oxide; propargite; tetradifon, chlorfenapyr, DNOC, bensultap, cartap hydrochloride, thiocyclam, and thiosultap-sodium, bistrifluoron, chlorfluazuron, diflubenzuron, flucycloxuron, flufenoxuron, hexaflumuron, lufenuron, novaluron, noviflumuron, penfluoron, teflubenzuron, and triflumuron, buprofezin, cyromazine, chromafenozide, halofenozide, methoxyfenozide, and tebufenozide, amitraz, hydramethylnon; acequinocyl or fluacrypyrim, fenazaquin, fenpyroximate, pyrimidifen, pyridaben, tebufenpyrad, tolfenpyrad or rotenone, indoxacarb; metaflumizone, spirodiclofen and spiromesifen, spirotetramat, aluminium phosphide, calcium phosphide, phosphine, and zinc phosphide or cyanide, cyenopyrafen, chlorantraniliprole (Rynaxypyr), Cyantraniliprole (Cyazypyr), and flubendiamide, azadirachtin, amidoflumet, benzoximate, bifenazate, chinomethionat, cryolite, cyflumetofen, dicofol, flufenerim, pyridalyl, and pyrifluquinazon, 4-{[(6-brompyrid-3-yl)methyl](2-fluorethyl)amino}furan-2(5H)-on (known from WO 2007/115644), 4-{[(6-fluorpyrid-3-yl)methyl](2,2-difluorethyl)amino}furan-2(5H)-on (known from WO 2007/115644), 4-{[(2-chlor-1,3-thiazol-5-yl)methyl](2-fluorethyl)amino}furan-2(5H)-on (known from WO 2007/115644), 4-{[(6-chlorpyrid-3-yl)methyl](2-fluorethyl)amino}furan-2(5H)-on (known from WO 2007/115644), 4-{[(6-chlorpyrid-3-yl)methyl](2,2-difluorethyl)amino}furan-2(5H)-on known from WO 2007/115644), 4-{[(6-chlor-5-fluorpyrid-3-yl)methyl](methyl)amino}furan-2(5H)-on (known from WO 2007/115643), 4-{[(5,6-dichlorpyrid-3-yl)methyl](2-fluorethyl)amino}furan-2(5H)-on (known from WO 2007/115646), 4-{[(6-chlor-5-fluorpyrid-3-yl)methyl](cyclopropyl)amino}furan-2(5H)-on (known from WO 2007/115643), 4-{[(6-chlorpyrid-3-yl)methyl](cyclopropyl)amino}furan-2(5H)-on (known from EP-A-0 539 588), 4-{[(6-chlorpyrid-3-yl)methyl](methyl)amino}furan-2(5H)-on (known from EP-A-0 539 588), [(6-chlorpyridin-3-yl)methyl](methyl)oxido-λ⁴-sulfanylidencyanamid (known from WO 2007/149134), [1-(6-chlorpyridin-3-yl)ethyl](methyl)oxido-λ⁴-sulfanylidencyanamid (known from WO 2007/149134) and its diastereomeres (A) and (B); [(6-trifluormethylpyridin-3-yl)methyl](methyl)oxido-λ⁴-sulfanylidencyanamid (known from WO 2007/095229), or sulfoxaflor (also known from WO 2007/149134), 11-(4-chloro-2,6-dimethylphenyl)-12-hydroxy-1,4-dioxa-9-azadispiro[4.2.4.2]tetradec-11-en-10-one (known from WO 2006/089633), 3-(4′-fluoro-2,4-dimethylbiphenyl-3-yl)-4-hydroxy-8-oxa-1-azaspiro[4.5]dec-3-en-2-one (known from WO 2008/067911), and 1-{2,4-dimethyl-5-[(2,2,2-trifluoroethyl)sulfinyl]phenyl}-3-(trifluoromethyl)-1H-1,2,4-triazole (known from WO 1999/55668), fluensulfone (5-chloro-2-[(3,4,4-trifluorobut-3-en-1-yl)sulfonyl]-1,3-thiazole), 1-[2-fluoro-4-methyl-5-[(2,2,2-trifluoroethyl)sulfinyl]phenyl]-3-(trifluoromethyl)-1H-1,2,4-Triazol-5-amine (bekannt aus WO 2006/043635), [(3S,4aR,12R,12aS,12bS)-3-[(Cyclopropylcarbonyl)oxy]-6,12-dihydroxy-4,12b-dimethyl-11-oxo-9-(pyridin-3-yl)-1,3,4,4a,5,6,6a,12,12a, 12b-decahydro-2H,11H-benzo[f]pyrano[4,3-b]chromen-4-yl]methylcyclopropancarboxylat (bekannt aus WO 2006/129714), 2-Cyan-3-(difluormethoxy)-N,N-dimethylbenzolsulfonamid (bekannt aus WO2006/056433), 2-Cyan-3-(difluormethoxy)-N-methylbenzolsulfonamid (bekannt aus WO2006/100288), 2-Cyan-3-(difluormethoxy)-N-ethylbenzolsulfonamid (bekannt aus WO2005/035486), 4-(Difluormethoxy)-N-ethyl-N-methyl-1,2-benzothiazol-3-amin-1,1-dioxid (bekannt aus WO2007/057407), N-[1-(2,3-Dimethylphenyl)-2-(3,5-dimethylphenyl)ethyl]-4,5-dihydro-1,3-thiazol-2-amin (bekannt aus WO2008/104503) furthermore products based on Bacillus firmus (I-1582, BioNeem, Votivo).

Particularly preferred combinations and or compositions comprise the amidine of formula (Ia) and at least one plant growth regulating compound of group (B-III), which is selected from the group consisting of clofibrin [2-(4-chlorophenoxy)-2-methylpropionic acid], 2,3,5-tri-iodobenzoic acid, 4-CPA (4-chlorophenoxyacetic acid), 2,4-D (2,4-dichlorophenoxyacetic acid), 2,4-DB [4-(2,4-dichlorophenoxy)butyric acid], 2,4-DEP {tris[2-(2,4-dichloro-phenoxy)ethyl]phosphit}, dichlorprop, fenoprop, IAA (β-indolacetic acid), IBA (4-indol-3-ylbutyric acid), naphthaleneacetamide, α-naphthaleneacetic acid, 1-naphthol, naphthoxyacetic acid, potassium naphthenate, sodium naphthenate, 2,4,5-T [(2,4,5-trichlorphenoxy)acetic acid], 2iP [N-(3-methylbut-2-enyl)-1H-purine-6-amine], benzyladenine, kinetin, zeatin, calcium cyanamide, dimethipin, endothal, ethephon, merphos, metoxuron, pentachlorphenol, thidiazuron, tribufos, aviglycine, aviglycine-hydrochloride, 1-methylcyclopropen, ACC (1-aminocyclopropancarboxylic acid), etacelasil, ethephon, glyoxime, gibberellines A1, A4, A7, gibberellinic acid (=gibberellin A3), abscisinic acid, ancymidol, butralin, carbaryl, chlorphonium or its chloride, chlorpropham, dikegulac, dikegulac-sodium, flumetralin, fluoridamide, fosamine, glyphosine, isopyrimol, jasmonic acid, maleic acid hydrazide or its potassium salt, mepiquat or its chloride, piproctanyl or its bromide, prohydrojasmon, propham, 2,3,5-tri-iodobenzoic acid, 2,6-diisopropylnaphthaline, cloprop, 1-naphthylacetic acid ethylester, isoprothiolane, MCPB-ethyl [4-(4-chloro-o-tolyloxy)butyric acid ethylester], N-acetylthiazolidine-4-carboxylic acid, n-decanol, pelargonic acid, N-phenylphthaliminic acid, tecnazene, triacontanol, 2,3-dihydro-5,6-diphenyl-1,4-oxathiin, 2-cyano-3-(2,4-dichlorophenyl)acrylic acid, 2-hydrazinoethanol, alorac, amidochlor, BTS 44584 [dimethyl(4-piperidinocarbonyloxy-2,5-xylyl)sulfonium-toluen-4-sulfonat], chloramben, chlorfluren, chlorfluren-methyl, dicamba-methyl, dichlorflurenol, dichlorflurenol-methyl, dimexano, etacelasil, hexafluoraceton-trihydrat, N-(2-ethyl-2H-pyrazol-3-yl)-N′-phenylurea, N-m-tolylphthalaminic acid, N-Pyrrolidinosuccinaminic acid, 3-tert-Butylphenoxyacetic acid propylester, pydanon, sodium (Z)-3-chloracrylate, chlorfluren, chlorflurenol, chlorflurenol-methyl, dichlorflurenol, flurenol, chlormequat, chlormequat-chlorid, daminozide, flurprimidol, mefluidide, mefluidide-diolamin, paclobutrazol, cyproconazole, tetcyclacis, uniconazole, uniconazole-P, brassinolides, forchlorfenuron, hymexazol, 2-amino-6-oxypurine derivatives, indolinon derivatives, 3,4-disubstituted maleimide derivatives and azepinon derivatives, benzofluor, buminafos, carvone, ciobutide, clofencet, clofence-potassium, cloxyfonac, cloxyfonac-Natrium, cyclanilide, cycloheximide, epocholeone, ethychlozate, ethylene, fenridazon, heptopargil, holosulf, inabenfide, karetazan, leadarsenate, methasulfocarb, prohexadione, prohexadione-Calcium, pydanon, sintofen, triapenthenol, trinexapac and trinexapac-ethyl.

In conjunction with the present invention compounds (A) and (B-I) to (B-III) are different from each other.

In the combinations according to the invention the compounds A and B are present in a synergistically effective weight ratio of A:B in a range of 100:1 to 1:100, preferably in a weight ratio of 50:1 to 1:50, most preferably in a weight ratio of 20:1 to 1:20. Further ratios of A:B which can be used according to the present invention with increasing preference in the order given are: 1000:1 to 1:1000, 750:1 to 1:750, 500:1 to 1:500, 400:1 to 1:400, 300:1 to 1:300, 250:1 to 1:250, 200:1 to 1:250, 175:1 to 1:175, 150:1 to 1:150, 125:1 to 1:125, 95:1 to 1:95, 90:1 to 1:90, 85:1 to 1:85, 80:1 to 1:80, 75:1 to 1:75, 70:1 to 1:70, 65:1 to 1:65, 60:1 to 1:60, 55:1 to 1:55, 45:1 to 1:45, 40:1 to 1:40, 35:1 to 1:35, 30:1 to 1:30, 25:1 to 1:25, 15:1 to 1:15, 10:1 to 1:10, 5:1 to 1:5, 4:1 to 1:4, 3:1 to 1:3, 2:1 to 1:2.

Where a compound (A) or a compound (B) can be present in tautomeric form, such a compound is understood hereinabove and hereinbelow also to include, where applicable, corresponding tautomeric forms, even when these are not specifically mentioned in each case.

Compounds (A) or compounds (B) having at least one basic centre are capable of forming, for example, acid addition salts, e.g. with strong inorganic acids, such as mineral acids, e.g. perchloric acid, sulfuric acid, nitric acid, nitrous acid, a phosphoric acid or a hydrohalic acid, with strong organic carboxylic acids, such as unsubstituted substituted, e.g. halo-substituted, C₁-C₄ alkanecarboxylic acids, e.g. acetic acid, saturated or unsaturated dicarboxylic acids, e.g. oxalic, malonic, succinic, maleic, fumaric and phthalic acid, hydroxycarboxylic acids, e.g. ascorbic, lactic, malic, tartaric and citric acid, or benzoic acid, or with organic sulfonic acids, such as unsubstituted or substituted, e.g. halo-substituted, C₁-C₄alkane- or aryl-sulfonic acids, e.g. methane- or p-toluene-sulfonic acid. Compounds (A) or compounds (B) having at least one acid group are capable of forming, for example, salts with bases, e.g. metal salts, such as alkali metal or alkaline earth metal salts, e.g. sodium, potassium or magnesium salts, or salts with ammonia or an organic amine, such as morpholine, piperidine, pyrrolidine, a mono-, di- or tri-lower alkylamine, e.g. ethyl-, diethyl-, triethyl- or dimethyl-propyl-amine, or a mono-, di- or tri-hydroxy-lower alkylamine, e.g. mono-, di- or tri-ethanolamine. In addition, corresponding internal salts may optionally be formed. In the context of the invention, preference is given to agrochemically advantageous salts. In view of the close relationship between the compounds (A) or the compounds (B) in free form and in the form of their salts, hereinabove and herein below any reference to the free compounds (A) or free compounds (B) or to their salts should be understood as including also the corresponding salts or the free compounds (A) or free compounds (B), respectively, where appropriate and expedient. The equivalent also applies to tautomers of compounds (A) or compounds (B) and to their salts or stereoisomers.

According to the invention the expression “combination” stands for the various combinations of compounds (A) and (B), for example in a single “ready-mix” form, in a combined spray mixture composed from separate formulations of the single active compounds, such as a “tank-mix”, and in a combined use of the single active ingredients when applied in a sequential manner, i.e. one after the other with a reasonably short period, such as a few hours or days. Preferably the order of applying the compounds (A) and (B) is not essential for working the present invention.

In a further aspect there is provided a composition comprising a combination according to this invention. A composition comprises at least one compound (A) according to formula (I) and one compound (B) as defined above. Preferably the fungicidal composition comprises an agriculturally acceptable support, carrier or filler.

According to the invention, the term “support” denotes a natural or synthetic, organic or inorganic compound with which the active compound of formula (I) is combined or associated to make it easier to apply, notably to the parts of the plant. This support is thus generally inert and should be agriculturally acceptable. The support may be a solid or a liquid. Examples of suitable supports include clays, natural or synthetic silicates, silica, resins, waxes, solid fertilisers, water, alcohols, in particular butanol, organic solvents, mineral and plant oils and derivatives thereof. Mixtures of such supports may also be used.

The composition according to the invention may also comprise additional components. In particular, the composition may further comprise a surfactant. The surfactant can be an emulsifier, a dispersing agent or a wetting agent of ionic or non-ionic type or a mixture of such surfactants. Mention may be made, for example, of polyacrylic acid salts, lignosulphonic acid salts, phenolsulphonic or naphthalenesulphonic acid salts, polycondensates of ethylene oxide with fatty alcohols or with fatty acids or with fatty amines, substituted phenols (in particular alkylphenols or arylphenols), salts of sulphosuccinic acid esters, taurine derivatives (in particular alkyl taurates), phosphoric esters of polyoxyethylated alcohols or phenols, fatty acid esters of polyols, and derivatives of the present compounds containing sulphate, sulphonate and phosphate functions. The presence of at least one surfactant is generally essential when the active compound and/or the inert support are water-insoluble and when the vector agent for the application is water. Preferably, surfactant content may be comprised from 5% to 40% by weight of the composition.

Colouring agents such as inorganic pigments, for example iron oxide, titanium oxide, ferrocyanblue, and organic pigments such as alizarin, azo and metallophthalocyanine dyes, and trace elements such as iron, manganese, boron, copper, cobalt, molybdenum and zinc salts can be used.

Optionally, other additional components may also be included, e.g. protective colloids, adhesives, thickeners, thixotropic agents, penetration agents, stabilisers, sequestering agents. More generally, the active compounds can be combined with any solid or liquid additive, which complies with the usual formulation techniques.

In general, the composition according to the invention may contain from 0.05 to 99% by weight of active compounds, preferably from 10 to 70% by weight.

The combination or composition according to the invention can be used as such, in form of their formulations or as the use forms prepared therefrom, such as aerosol dispenser, capsule suspension, cold fogging concentrate, dustable powder, emulsifiable concentrate, emulsion oil in water, emulsion water in oil, encapsulated granule, fine granule, flowable concentrate for seed treatment, gas (under pressure), gas generating product, granule, hot fogging concentrate, macrogranule, microgranule, oil dispersible powder, oil miscible flowable concentrate, oil miscible liquid, paste, plant rodlet, powder for dry seed treatment, seed coated with a pesticide, soluble concentrate, soluble powder, solution for seed treatment, suspension concentrate (flowable concentrate), ultra low volume (ULV) liquid, ultra low volume (ULV) suspension, water dispersible granules or tablets, water dispersible powder for slurry treatment, water soluble granules or tablets, water soluble powder for seed treatment and wettable powder.

The treatment of plants and plant parts with the active compound combination or composition according to the invention is carried out directly or by action on their environment, habitat or storage area by means of the normal treatment methods, for example by watering (drenching), drip irrigation, spraying, atomizing, broadcasting, dusting, foaming, spreading-on, and as a powder for dry seed treatment, a solution for seed treatment, a water-soluble powder for seed treatment, a water-soluble powder for slurry treatment, or by encrusting.

These active compound combinations or compositions include not only compositions which are ready to be applied to the plant or seed to be treated by means of a suitable device, such as a spraying or dusting device, but also concentrated commercial compositions which must be diluted before application to the crop.

The active compounds within the composition according to the invention have potent fungicidal activity and can be employed for controlling undesired fungi in crop protection or in the protection of materials.

Within the active compound combinations or compositions according to the invention, fungicide compounds can be employed in crop protection for example for controlling fungi being Plasmodiophoromycetes, Oomycetes, Chytridiomycetes, Zygomycetes, Ascomycetes, Basidiomycetes and Deuteromycetes.

The active compound combination or composition according to the invention can be used to curatively or preventively control the phytopathogenic fungi of plants or reducing the mycotoxin contamination of plant or plant material. Thus, according to a further aspect of the invention, there is provided a method for curatively or preventively controlling the phytopathogenic fungi of plants or reducing the mycotoxin contamination of plant or plant parts comprising the use of a composition according to the invention by application to the seed, the plant or to the fruit of the plant or to the soil in which the plant is growing or in which it is desired to grow.

The active compound combination or composition of the invention is also suitable for the treatment of seeds. A large part of the damage caused by fungi on cultigens occurs by infestation of the seed during storage and after sowing the seed in the ground as well as during and after germination of the plants. This phase is especially critical since the roots and shoots of the growing plant are particularly sensitive and even a small amount of damage can lead to withering of the whole plant.

In a particular embodiment of the invention plant or plant has at least 10% less mycotoxin, more preferable at least 20% mycotoxin, more preferable at least 40% mycotoxin, more preferable at least 50% mycotoxin, more preferable at least 80% mycotoxin contamination than plant or plant material which has not been treated.

The method of treatment according to the invention may also be useful to treat propagation material such as tubers or rhizomes, but also seeds, seedlings or seedlings pricking out and plants or plants pricking out. This method of treatment can also be useful to treat roots. The method of treatment according to the invention can also be useful to treat the over-ground parts of the plant such as trunks, stems or stalks, leaves, flowers and fruit of the concerned plant.

By plant parts is meant all above ground and below ground parts and organs of plants such as shoot, leaf, flower, blossom and root, whereby for example leaves, needles, stems, branches, blossoms, fruiting bodies, fruits and seed as well as roots, corms and rhizomes are listed. Crops and vegetative and generative propagating material, for example cuttings, corms, rhizomes, runners, tubers, grains, and seeds also belong to plant parts

Among the plants that can be protected by the method according to the invention, mention may be made of major field crops like corn, soybean, cotton, Brassica oilseeds such as Brassica napus (e.g. canola), Brassica rapa, B. juncea (e.g. mustard) and Brassica carinata, rice, wheat, sugarbeet, sugarcane, oats, rye, barley, millet, triticale, flax, vine and various fruits and vegetables of various botanical taxa such as Rosaceae sp. (for instance pip fruit such as apples and pears, but also stone fruit such as apricots, cherries, almonds and peaches, berry fruits such as strawberries), Ribesiokdae sp., Juglandaceae sp., Betulaceae sp., Anacardiaceae sp., Fagaceae sp., Moraceae sp., Oleaceae sp., Actinidaceae sp., Laurceae sp., Musaceae sp. (for instance banana trees and plantings), Rubiaceae sp. (for instance coffee), Theaceae sp., Sterculiceae sp., Rutaceae sp. (for instance lemons, oranges and grapefruit); Solanaceae sp. (for instance tomatoes, potatoes, peppers, eggplant), Liliaceae sp., Compositiae sp. (for instance lettuce, artichoke and chicory—including root chicory, endive or common chicory), Umbelliferae sp. (for instance carrot, parsley, celery and celeriac), Cucurbitaceae sp. (for instance cucumber—including pickling cucumber, squash, watermelon, gourds and melons), Alliaceae sp. (for instance onions and leek), Cruciferae sp. (for instance white cabbage, red cabbage, broccoli, cauliflower, brussel sprouts, pak choi, kohlrabi, radish, horseradish, cress, Chinese cabbage), Leguminosae sp. (for instance peanuts, peas and beans beans—such as climbing beans and broad beans), Chenopodiaceae sp. (for instance mangold, spinach beet, spinach, beetroots), Asteraceae sp. (for instance sunflower), Brassicaceae sp. (for instance white cabbage, red cabbage, brokkoli, cauliflower, brussel sprouts, pak choi, kohlrabi, radish as well as canola, rapeseed, mustard, horseradish, cress), (Cruciferae sp. (for instance colza), Fabacae sp. (for instance peanuts and beans), Papilionaceae sp. (for instance soybean), Solanaceae sp. (for instance potatoes), Malvaceae (for instance okra), Asparagaceae (for instance asparagus); horticultural and forest crops; ornamental plants; as well as genetically modified homologues of these crops.

According to the invention all cereal, nut, fruit and spice plants are comprised, in particular cereals like all wheat species, rye, barley, triticale, rice, sorghum, oats, millets, quinoa, buckwheat, fonio, amaranth, teff and durum; in particular fruits of various botanical taxa such as Rosaceae sp. (for instance pip fruit such as apples and pears, but also stone fruit such as apricots, cherries, almonds and peaches, berry fruits such as strawberries), Vitis sp. (for instance Vitis vinifera: grape vine, raisins), Manihoteae sp. (for instance Manihot esculenta, manioc), Theobroma sp. (for instance Theobroma cacao: cocoa), Ribesioidae sp., Juglandaceae sp., Betulaceae sp., Anacardiaceae sp., Fagaceae sp., Moraceae sp., Oleaceae sp., Actinidaceae sp., Lauraceae sp., Musaceae sp. (for instance banana trees and plantings), Rubiaceae sp. (for instance coffee), Theaceae sp., Sterculiceae sp., Rutaceae sp. (for instance lemons, oranges and grapefruit); Solanaceae sp. (for instance tomatoes, potatoes, peppers, eggplant), Liliaceae sp.; in particular nuts of various botanical taxa such as peanuts, Julandaceae sp. (Walnut, Persian Walnut (Juglans regia), Butternut (Juglans), Hickory, Shagbark Hickory, Pecan (Carya), Wingnut (Pterocarya)) Fafaceae sp. (Chestnut (Castanea), Chestnuts, including Chinese Chestnut, Malabar chestnut, Sweet Chestnut, Beech (Fagus), Oak (Quercus), Stone-oak Tanoak (Lithocarpus)); Betulaceae sp. (Alder (Alnus), Birch (Betula), Hazel Filbert (Corylus), Hornbeam) Leguminosae sp. (for instance peanuts, peas and beans beans—such as climbing beans and broad beans), Asteraceae sp. (for instance sunflower seed), Almond, Beech, Butternut, Brazil nut, Candlenut, Cashew, Colocynth, Cotton seed, Cucurbita ficifolia, Filbert, Indian Beech or Pongam Tree, Kola nut, Lotus seed, Macadamia, Mamoncillo, Maya nut, Mongongo, Oak acorns, Ogbono nut, Paradise nut, Pili nut, Pine nut, Pistacchio, Pumpkin seed, water Caltrop; soybeans (Glycine sp., Glycine max); in particular spices like Ajwain (Trachyspermum ammi), Allspice (Pimenta dioica), Alkanet (Anchusa arvensis), Amchur—mango powder (Mangifera), Angelica (Angelica archangelica), Anise (Pimpinella anisum), Aniseed myrtle (Syzygium anisatum), Annatto (Bixa orellana L.), Apple mint (Mentha suaveolens), Artemisia vulgaris/Mugwort, Asafoetida (Ferula assafoetida), Berberis, Banana, Basil (Ocimum basilicum), Bay leaves, Bistort (Persicaria bistorta”), Black cardamom, Black cumin, Blackcurrant, Black limes, Bladder wrack (Fucus vesiculosus), Blue Cohosh, Blue-leaved Mallee (Eucalyptus polybractea), Bog Labrador Tea (Rhododendron groenlandicum), Boldo (Peumus boldus), Bolivian Coriander (Porophyllum ruderale) Borage (Borago officinalis), Calamus, Calendula, Calumba (Jateorhiza calumba), Chamomile, Candle nut, Cannabis, Caper (Capparis spinosa), Caraway, Cardamom, Carob Pod, Cassia, Casuarina, Catnip, Cat's Claw, Catsear, Cayenne pepper, Celastrus Paniculatus—Herb., Celery salt, Celery seed, Centaury, Chervil (Anthriscus cerefolium), Chickweed, Chicory, Chile pepper, Chili powder, Cinchona, Chives (Allium schoenoprasum), Cicely (Myrrhis odorata), Cilantro (see Coriander) (Coriandrum sativum), Cinnamon (and Cassia), Cinnamon Myrtle (Backhousia myrtifolia), Clary, Cleavers, Clover, Cloves, Coffee, Coltsfoot, Comfrey, Common Rue, Condurango, Coptis, Coriander, Costmary (Tanacetum balsamita), Couchgrass, Cow Parsley (Anthriscus sylvestris), Cowslip, Cramp Bark (Viburnum opulus), Cress, Cuban Oregano (Plectranthus amboinicus), Cudweed, Cumin, Curry leaf (Murraya koenigii), Damiana (Turera aphrodisiaca, T. diffusa), Dandelion (Taraxacum officinale), Demulcent, Devil's claw (Harpagophytum procumbens), Dill seed, Dill (Anethum graveolens), Dorrigo Pepper (Tasmannia stipitata), Echinacea—, Echinopanax Elatum, Edelweiss, Elderberry, Elderflower, Elecampane, Eleutherococcus senticosus, Emmenagogue, Epazote (Chenopodium ambrosioides), Ephedra —, Eryngium foetidum, Eucalyptus, Fennel (Foeniculum vulgare), Fenugreek, Feverfew, Figwort, Filé powder, Five-spice powder (Chinese), Fo-ti-tieng, Fumitory, Galangal, Garam masala, Garden cress, Garlic chives, Garlic, Ginger (Zingiber officinale), Ginkgo biloba, Ginseng, Ginseng, Siberian (Eleutherococcus senticosus), Goat's Rue (Galega officinalis), Goada masala, Golden Rod, Golden Seal, Gotu Kola, Grains of paradise (Aframomum melegueta), Grains of Selim (Xylopia aethiopica), Grape seed extract, Green tea, Ground Ivy, Guaco, Gypsywort, Hawthorn (Crataegus sanguinea), Hawthorne Tree, Hemp, Herbes de Provence, Hibiscus, Holly, Holy Thistle, Hops, Horehound, Horseradish, Horsetail (Equisetum telmateia), Hyssop (Hyssopus officinalis), Jalap, Jasmine, Jiaogulan (Gynostemma pentaphyllum), Joe Pye weed (Gravelroot), John the Conqueror, Juniper, Kaffir Lime Leaves (Citrus hystrix, C. papedia), Kaala masala, Knotweed, Kokam, Labrador tea, Lady's Bedstraw, Lady's Mantle, Land cress, Lavender (Lavandula spp.), Ledum, Lemon Balm (Melissa Officinalis), Lemon basil, Lemongrass (Cymbopogon citratus, C. flexuosus, and other species), Lemon Ironbark (Eucalyptus staigeriana), Lemon mint, Lemon Myrtle (Backhousia citriodora), Lemon Thyme, Lemon verbena (Lippia citriodora), Licorice—adaptogen, Lime Flower, Limnophila aromatica, Lingzhi, Linseed, Liquorice, Long pepper, Lovage (Levisticum officinale), Luohanguo, Mace, Mahlab, Malabathrum, Manchurian Thorn Tree (Aralia manchurica)]], Mandrake, Marjoram (Origanum majorana), Marrubium vulgare, Marsh Labrador Tea, Marshmallow, Mastic, Meadowsweet, Mei Yen, Melegueta pepper (Aframomum melegueta), Mint (Mentha spp.), Milk thistle (Silybum), Bergamot (Monarda didyma), Motherwort, Mountain Skullcap, Mullein (Verbascum thapsus), Mustard, Mustard seed, Nashia inaguensis, Neem, Nepeta, Nettle, Nigella sativa, Nigella (Kolanji, Black caraway), Noni, Nutmeg (and Mace) Marijuana, Oenothera (Oenothera biennis et al), Olida (Eucalyptus olida), Oregano (Origanum vulgare, O. heracleoticum, and other species), Orris root, Osmorhiza, Olive Leaf (used in tea and as herbal supplement), Panax quinquefolius, Pandan leaf, Paprika, Parsley (Petroselinum crispum), Passion Flower, Patchouli, Pennyroyal, Pepper (black, white, and green), Peppermint, Peppermint Gum (Eucalyptus dives), Perilla, Plantain, Pomegranate, Ponch phoran, Poppy seed, Primrose (Primula)—candied flowers, tea, Psyllium, Purslane, Quassia, Quatre Epices, Ramsons, Ras el-hanout, Raspberry (leaves), Reishi, Restharrow, Rhodiola rosea, Riberry (Syzygium luehmannii), Rocket/Arugula, Roman chamomile, Rooibos, Rosehips, Rosemary (Rosmarinus officinalis), Rowan Berries, Rue, Safflower, Saffron, Sage (Salvia officinalis), Saigon Cinnamon, St John's Wort, Salad Burnet (Sanguisorba minor or Poterium sanguisorba), Salvia, Sichuan Pepper (Sansho), Sassafras, Savory (Satureja hortensis, S. Montana), Schisandra (Schisandra chinensis), Scutellaria costaricana, Senna (herb), Senna obtusifolia, Sesame seed, Sheep Sorrel, Shepherd's Purse, Sialagogue, Siberian Chaga, Siberian ginseng (Eleutherococcus senticosus), Siraitia grosvenorii (luohanguo), Skullcap, Sloe Berries, Smudge Stick, Sonchus, Sorrel (Rumex spp.), Southernwood, Spearmint, Speedwell, Squill, Star anise, Stevia, Strawberry Leaves, Suma (Pfaffia paniculata), Sumac, Summer savory, Sutherlandia frutescens, Sweet grass, Sweet cicely (Myrrhis odorata), Sweet woodruff, Szechuan pepper (Xanthoxylum piperitum), Tacamahac, Tamarind, Tandoori masala, Tansy, Tarragon (Artemisia dracunculus), Tea, Teucrium polium, Thai basil, Thistle, Thyme, Toor Dall, Tormentil, Tribulus terrestris, Tulsi (Ocimum tenuiflorum), Turmeric (Curcuma longa), Uva Ursi also known as Bearberry, Vanilla (Vanilla planifolia), Vasaka, Vervain, Vetiver, Vietnamese Coriander (Persicaria odorata), Wasabi (Wasabia japonica), Watercress, Wattleseed, Wild ginger, Wild Lettuce, Wild thyme, Winter savory, Witch Hazel, Wolfberry, Wood Avens, Wood Betony, Woodruff, Wormwood, Yarrow, Yerba Buena, Yohimbe, Za'atar, Zedoary Root.

The method of treatment according to the invention is used in the treatment of plants. By plants is meant all plants and plant populations such as desirable and undesirable wild plants, cultivars and plant varieties (whether or not protectable by plant variety or plant breeder's rights). Cultivars and plant varieties can be plants obtained by conventional propagation and breeding methods which can be assisted or supplemented by one or more biotechnological methods such as by use of double haploids, protoplast fusion, random and directed mutagenesis, homologous recombination methods, molecular or genetic markers or by bioengineering and genetic engineering methods or marker-assisted breeding methods, for example SMART breeding (“Selection with Markers and Advanced Reproductive Technologies”). Plants can also be genetically modified organisms (GMOs). Genetically modified plants (or transgenic plants) are plants of which a heterologous gene has been stably integrated into the genome. The expression “heterologous gene” essentially means a gene which is provided or assembled outside the plant and when introduced in the nuclear, chloroplastic or mitochondrial genome gives the transformed plant new or improved agronomic or other properties by expressing a protein or polypeptide of interest or by downregulating or silencing other gene(s) which are present in the plant (using for example, antisense technology, co-suppression technology or RNA interference—RNAi—technology). A heterologous gene that is located in the genome is also called a transgene. A transgene that is defined by its particular location in the plant genome is called a transformation or transgenic event.

Plants and plant cultivars which may also be treated according to the invention, are those plants characterized by enhanced yield characteristics. Increased yield in said plants can be the result of, for example, improved plant physiology, growth and development, such as water use efficiency, water retention efficiency, improved nitrogen use, enhanced carbon assimilation, improved photosynthesis, increased germination efficiency and accelerated maturation. Yield can furthermore be affected by improved plant architecture (under stress and non-stress conditions), including but not limited to, early flowering, flowering control for hybrid seed production, seedling vigor, plant size, internode number and distance, root growth, seed size, fruit size, pod size, pod or ear number, seed number per pod or ear, seed mass, enhanced seed filling, reduced seed dispersal, reduced pod dehiscence and lodging resistance. Further yield traits include seed composition, such as carbohydrate content, protein content, oil content and composition, nutritional value, reduction in anti-nutritional compounds, improved processability and better storage stability.

Plants that may be treated according to the invention are hybrid plants that already express the characteristic of heterosis or hybrid vigor which results in generally higher yield, vigor, health and resistance towards biotic and abiotic stress factors. Such plants are typically made by crossing an inbred male-sterile parent line (the female parent) with another inbred male-fertile parent line (the male parent). Hybrid seed is typically harvested from the male sterile plants and sold to growers. Male sterile plants can sometimes (e.g. in corn) be produced by detasseling, i.e. the mechanical removal of the male reproductive organs (or males flowers) but, more typically, male sterility is the result of genetic determinants in the plant genome. In that case, and especially when seed is the desired product to be harvested from the hybrid plants it is typically useful to ensure that male fertility in the hybrid plants is fully restored. This can be accomplished by ensuring that the male parents have appropriate fertility restorer genes which are capable of restoring the male fertility in hybrid plants that contain the genetic determinants responsible for male-sterility. Genetic determinants for male sterility may be located in the cytoplasm. Examples of cytoplasmic male sterility (CMS) were for instance described in Brassica species. However, genetic determinants for male sterility can also be located in the nuclear genome. Male sterile plants can also be obtained by plant biotechnology methods such as genetic engineering. A particularly useful means of obtaining male-sterile plants is described in WO 89/10396 in which, for example, a ribonuclease such as barnase is selectively expressed in the tapetum cells in the stamens. Fertility can then be restored by expression in the tapetum cells of a ribonuclease inhibitor such as barstar.

Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) which may be treated according to the invention are herbicide-tolerant plants, i.e. plants made tolerant to one or more given herbicides. Such plants can be obtained either by genetic transformation, or by selection of plants containing a mutation imparting such herbicide tolerance.

Herbicide-tolerant plants are for example glyphosate-tolerant plants, i.e. plants made tolerant to the herbicide glyphosate or salts thereof. Plants can be made tolerant to glyphosate through different means. For example, glyphosate-tolerant plants can be obtained by transforming the plant with a gene encoding the enzyme 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS). Examples of such EPSPS genes are the AroA gene (mutant CT7) of the bacterium Salmonella typhimurium, the CP4 gene of the bacterium Agrobacterium sp, the genes encoding a Petunia EPSPS, a Tomato EPSPS, or an Eleusine EPSPS. It can also be a mutated EPSPS. Glyphosate-tolerant plants can also be obtained by expressing a gene that encodes a glyphosate oxido-reductase enzyme. Glyphosate-tolerant plants can also be obtained by expressing a gene that encodes a glyphosate acetyl transferase enzyme. Glyphosate-tolerant plants can also be obtained by selecting plants containing naturally-occurring mutations of the above-mentioned genes.

Other herbicide resistant plants are for example plants that are made tolerant to herbicides inhibiting the enzyme glutamine synthase, such as bialaphos, phosphinothricin or glufosinate. Such plants can be obtained by expressing an enzyme detoxifying the herbicide or a mutant glutamine synthase enzyme that is resistant to inhibition. One such efficient detoxifying enzyme is an enzyme encoding a phosphinothricin acetyltransferase (such as the bar or pat protein from Streptomyces species). Plants expressing an exogenous phosphinothricin acetyltransferase are also described.

Further herbicide-tolerant plants are also plants that are made tolerant to the herbicides inhibiting the enzyme hydroxyphenylpyruvatedioxygenase (HPPD). Hydroxyphenylpyruvatedioxygenases are enzymes that catalyze the reaction in which para-hydroxyphenylpyruvate (HPP) is transformed into homogentisate. Plants tolerant to HPPD-inhibitors can be transformed with a gene encoding a naturally-occurring resistant HPPD enzyme, or a gene encoding a mutated HPPD enzyme. Tolerance to HPPD-inhibitors can also be obtained by transforming plants with genes encoding certain enzymes enabling the formation of homogentisate despite the inhibition of the native HPPD enzyme by the HPPD-inhibitor. Tolerance of plants to HPPD inhibitors can also be improved by transforming plants with a gene encoding an enzyme prephenate dehydrogenase in addition to a gene encoding an HPPD-tolerant enzyme.

Still further herbicide resistant plants are plants that are made tolerant to acetolactate synthase (ALS) inhibitors. Known ALS-inhibitors include, for example, sulfonylurea, imidazolinone, triazolopyrimidines, pyrimidinyoxy(thio)benzoates, and/or sulfonylaminocarbonyltriazolinone herbicides. Different mutations in the ALS enzyme (also known as acetohydroxyacid synthase, AHAS) are known to confer tolerance to different herbicides and groups of herbicides. The production of sulfonylurea-tolerant plants and imidazolinonetolerant plants is described. Other imidazolinone-tolerant plants are also described. Further sulfonylurea- and imidazolinone-tolerant plants are also described in for example WO 2007/024782.

Other plants tolerant to imidazolinone and/or sulfonylurea can be obtained by induced mutagenesis, selection in cell cultures in the presence of the herbicide or mutation breeding as described for example for soybeans, for rice, for sugar beet, for lettuce, or for sunflower.

Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) which may also be treated according to the invention are insect-resistant transgenic plants, i.e. plants made resistant to attack by certain target insects. Such plants can be obtained by genetic transformation, or by selection of plants containing a mutation imparting such insect resistance.

An “insect-resistant transgenic plant”, as used herein, includes any plant containing at least one transgene comprising a coding sequence encoding:

• 1) an insecticidal crystal protein from Bacillus thuringiensis or an insecticidal portion thereof, such as the insecticidal crystal proteins listed by Crickmore et al., Microbiology and Molecular Biology Reviews (1998), 62, 807-813, updated by Crickmore et al. (2005) at the Bacillus thuringienis toxin nomenclature, online at http://www.lifesci.sussex.ac.uk/Home/Neil_Crickmore/Bt/), or insecticidal portions thereof, e.g., proteins of the Cry protein classes Cry1Ab, Cry1Ac, Cry1F, Cry2Ab, Cry3Aa, or Cry3Bb or insecticidal portions thereof; or
• 2) a crystal protein from Bacillus thuringiensis or a portion thereof which is insecticidal in the presence of a second other crystal protein from Bacillus thuringiensis or a portion thereof, such as the binary toxin made up of the Cry34 and Cry35 crystal proteins; or
• 3) a hybrid insecticidal protein comprising parts of different insecticidal crystal proteins from Bacillus thuringiensis, such as a hybrid of the proteins of 1) above or a hybrid of the proteins of 2) above, e.g., the Cry1A.105 protein produced by corn event MON98034; or
• 4) a protein of any one of 1) to 3) above wherein some, particularly 1 to 10, amino acids have been replaced by another amino acid to obtain a higher insecticidal activity to a target insect species, and/or to expand the range of target insect species affected, and/or because of changes introduced into the encoding DNA during cloning or transformation, such as the Cry3Bb1 protein in corn events MON863 or MON88017, or the Cry3A protein in corn event MIR604;
• 5) an insecticidal secreted protein from Bacillus thuringiensis or Bacillus cereus, or an insecticidal portion thereof, such as the vegetative insecticidal (VIP) proteins listed at:
  • http://www.lifesci.sussex.ac.uk/home/Neil_Crickmore/Bt/vip.html, e.g., proteins from the VIP3Aa protein class; or
• 6) secreted protein from Bacillus thuringiensis or Bacillus cereus which is insecticidal in the presence of a second secreted protein from Bacillus thuringiensis or B. cereus, such as the binary toxin made up of the VIP1A and VIP2A proteins; or
• 7) hybrid insecticidal protein comprising parts from different secreted proteins from Bacillus thuringiensis or Bacillus cereus, such as a hybrid of the proteins in 1) above or a hybrid of the proteins in 2) above; or
• 8) protein of any one of 1) to 3) above wherein some, particularly 1 to 10, amino acids have been replaced by another amino acid to obtain a higher insecticidal activity to a target insect species, and/or to expand the range of target insect species affected, and/or because of changes introduced into the encoding DNA during cloning or transformation (while still encoding an insecticidal protein), such as the VIP3Aa protein in cotton event COT102.

Of course, an insect-resistant transgenic plant, as used herein, also includes any plant comprising a combination of genes encoding the proteins of any one of the above classes 1 to 8. In one embodiment, an insect-resistant plant contains more than one transgene encoding a protein of any one of the above classes 1 to 8, to expand the range of target insect species affected when using different proteins directed at different target insect species, or to delay insect resistance development to the plants by using different proteins insecticidal to the same target insect species but having a different mode of action, such as binding to different receptor binding sites in the insect.

Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) which may also be treated according to the invention are tolerant to abiotic stresses. Such plants can be obtained by genetic transformation, or by selection of plants containing a mutation imparting such stress resistance. Particularly useful stress tolerance plants include:

• • a. plants which contain a transgene capable of reducing the expression and/or the activity of poly(ADP-ribose)polymerase (PARP) gene in the plant cells or plants
  • b. plants which contain a stress tolerance enhancing transgene capable of reducing the expression and/or the activity of the PARG encoding genes of the plants or plants cells.
  • c. plants which contain a stress tolerance enhancing transgene coding for a plant-functional enzyme of the nicotinamide adenine dinucleotide salvage synthesis pathway including nicotinamidase, nicotinate phosphoribosyltransferase, nicotinic acid mononucleotide adenyl transferase, nicotinamide adenine dinucleotide synthetase or nicotine amide phosphorybosyltransferase.

Further particularly genetically modified plants include plants containing a gene in an agronomically neutral or beneficial position as described by the event listed in Table A

TABLE A
Event	Company	Description	Crop
ASR368	Scotts Seeds	Glyphosate tolerance derived by inserting a modified 5-	Agrostis stolonifera
		enolpyruvylshikimate-3-phosphate synthase (EPSPS)	Creeping Bentgrass
		encoding gene from Agrobacterium tumefaciens, parent
		line B99061
H7-1	Monsanto Company	Glyphosate herbicide tolerant sugar beet produced by	Beta vulgaris
		inserting a gene encoding the enzyme 5-
		enolypyruvylshikimate-3-phosphate synthase (EPSPS)
		from the CP4 strain of Agrobacterium tumefaciens.
T120-7	Bayer CropScience (Aventis	Introduction of the PPT-acetyltransferase (PAT) encoding	Beta vulgaris
	CropScience(AgrEvo))	gene from Streptomyces viridochromogenes, an aerobic
		soil bacteria. PPT normally acts to inhibit glutamine
		synthetase, causing a fatal accumulation of ammonia.
		Acetylated PPT is inactive.
GTSB77	Novartis Seeds; Monsanto	Glyphosate herbicide tolerant sugar beet produced by	Beta vulgaris sugar Beet
	Company	inserting a gene encoding the enzyme 5-
		enolypyruvylshikimate-3-phosphate synthase (EPSPS)
		from the CP4 strain of Agrobacterium tumefaciens.
23-18-17, 23-198	Monsanto Company (formerly	High laurate (12:0) and myristate (14:0) canola produced	Brassica napus (Argentine
	Calgene)	by inserting a thioesterase encoding gene from the	Canola)
		California bay laurel (Umbellularia californica).
45A37, 46A40	Pioneer Hi-Bred International Inc.	High oleic acid and low linolenic acid canola produced	Brassica napus (Argentine
		through a combination of chemical mutagenesis to select	Canola)
		for a fatty acid desaturase mutant with elevated oleic acid,
		and traditional back-crossing to introduce the low linolenic
		acid trait.
46A12, 46A16	Pioneer Hi-Bred International Inc.	Combination of chemical mutagenesis, to achieve the high	Brassica napus (Argentine
		oleic acid trait, and traditional breeding with registered	Canola)
		canola varieties.
GT200	Monsanto Company	Glyphosate herbicide tolerant canola produced by inserting	Brassica napus (Argentine
		genes encoding the enzymes 5-enolypyruvylshikimate-3-	Canola)
		phosphate synthase (EPSPS) from the CP4 strain of
		Agrobacterium tumefaciens and glyphosate oxidase from
		Ochrobactrum anthropi.
GT73, RT73	Monsanto Company	Glyphosate herbicide tolerant canola produced by inserting	Brassica napus (Argentine
		genes encoding the enzymes 5-enolypyruvylshikimate-3-	Canola)
		phosphate synthase (EPSPS) from the CP4 strain of
		Agrobacterium tumefaciens and glyphosate oxidase from
		Ochrobactrum anthropi.
HCN10	Aventis CropScience	Introduction of the PPT-acetyltransferase (PAT) encoding	Brassica napus (Argentine
		gene from Streptomyces viridochromogenes, an aerobic	Canola)
		soil bacteria. PPT normally acts to inhibit glutamine
		synthetase, causing a fatal accumulation of ammonia.
		Acetylated PPT is inactive.
HCN92	Bayer CropScience (Aventis	Introduction of the PPT-acetyltransferase (PAT) encoding	Brassica napus (Argentine
	CropScience(AgrEvo))	gene from Streptomyces viridochromogenes, an aerobic	Canola)
		soil bacteria. PPT normally acts to inhibit glutamine
		synthetase, causing a fatal accumulation of ammonia.
		Acetylated PPT is inactive.
MS1, RF1 => PGS1	Aventis CropScience (formerly	Male-sterility, fertility restoration, pollination control	Brassica napus (Argentine
	Plant Genetic Systems)	system displaying glufosinate herbicide tolerance. MS lines	Canola)
		contained the barnase gene from Bacillus
		amyloliquefaciens, RF lines contained the barstar gene
		from the same bacteria, and both lines contained the
		phosphinothricin N-acetyltransferase (PAT) encoding gene
		from Streptomyces hygroscopicus.
MS1, RF2 => PGS2	Aventis CropScience (formerly	Male-sterility, fertility restoration, pollination control	Brassica napus (Argentine
	Plant Genetic Systems)	system displaying glufosinate herbicide tolerance. MS lines	Canola)
		contained the barnase gene from Bacillus
		amyloliquefaciens, RF lines contained the barstar gene
		from the same bacteria, and both lines contained the
		phosphinothricin N-acetyltransferase (PAT) encoding gene
		from Streptomyces hygroscopicus.
MS8 × RF3	Bayer CropScience (Aventis	Male-sterility, fertility restoration, pollination control	Brassica napus (Argentine
	CropScience(AgrEvo))	system displaying glufosinate herbicide tolerance. MS lines	Canola)
		contained the barnase gene from Bacillus
		amyloliquefaciens, RF lines contained the barstar gene
		from the same bacteria, and both lines contained the
		phosphinothricin N-acetyltransferase (PAT) encoding gene
		from Streptomyces hygroscopicus.
NS738, NS1471,	Pioneer Hi-Bred International Inc.	Selection of somaclonal variants with altered acetolactate	Brassica napus (Argentine
NS1473		synthase (ALS) enzymes, following chemical mutagenesis.	Canola)
		Two lines (P1, P2) were initially selected with
		modifications at different unlinked loci. NS738 contains the
		P2 mutation only.
OXY-235	Aventis CropScience (formerly	Tolerance to the herbicides bromoxynil and ioxynil by	Brassica napus (Argentine
	Rhone Poulenc Inc.)	incorporation of the nitrilase gene from Klebsiella	Canola)
		pneumoniae.
PHY14, PHY35	Aventis CropScience (formerly	Male sterility was via insertion of the barnase ribonuclease	Brassica napus (Argentine
	Plant Genetic Systems)	gene from Bacillus amyloliquefaciens; fertility restoration	Canola)
		by insertion of the barstar RNase inhibitor; PPT resistance
		was via PPT-acetyltransferase (PAT) from Streptomyces
		hygroscopicus.
PHY36	Aventis CropScience (formerly	Male sterility was via insertion of the barnase ribonuclease	Brassica napus (Argentine
	Plant Genetic Systems)	gene from Bacillus amyloliquefaciens; fertility restoration	Canola)
		by insertion of the barstar RNase inhibitor; PPT resistance
		was via PPT-acetyltransferase (PAT) from Streptomyces
		hygroscopicus.
T45 (HCN28)	Bayer CropScience (Aventis	Introduction of the PPT-acetyltransferase (PAT) encoding	Brassica napus (Argentine
	CropScience(AgrEvo))	gene from Streptomyces viridochromogenes, an aerobic	Canola)
		soil bacteria. PPT normally acts to inhibit glutamine
		synthetase, causing a fatal accumulation of ammonia.
		Acetylated PPT is inactive.
HCR-1	Bayer CropScience (Aventis	Introduction of the glufosinate ammonium herbicide	Brassica rapa (Polish
	CropScience(AgrEvo))	tolerance trait from transgenic B. napus line T45. This trait	Canola)
		is mediated by the phosphinothricin acetyltransferase
		(PAT) encoding gene from S. viridochromogenes.
ZSR500/502	Monsanto Company	Introduction of a modified 5-enol-pyruvylshikimate-3-	Brassica rapa (Polish
		phosphate synthase (EPSPS) and a gene from	Canola)
		Achromobacter sp that degrades glyphosate by conversion
		to aminomethylphosphonic acid (AMPA) and glyoxylate
		by interspecific crossing with GT73.
55-1/63-1	Cornell University	Papaya ringspot virus (PRSV) resistant papaya produced by	Carica papaya (Papaya)
		inserting the coat protein (CP) encoding sequences from
		this plant potyvirus.
RM3-3, RM3-4,	Bejo Zaden BV	Male sterility was via insertion of the barnase ribonuclease	Cichorium
RM3-6		gene from Bacillus amyloliquefaciens; PPT resistance was	intybus (Chicory)
		via the bar gene from S. hygroscopicus, which encodes the
		PAT enzyme.
A, B	Agritope Inc.	Reduced accumulation of S-adenosylmethionine (SAM),	Cucumis melo (Melon)
		and consequently reduced ethylene synthesis, by
		introduction of the gene encoding S-adenosylmethionine
		hydrolase.
CZW-3	Asgrow (USA); Seminis	Cucumber mosiac virus (CMV), zucchini yellows mosaic	Cucurbita pepo (Squash)
	Vegetable Inc. (Canada)	(ZYMV) and watermelon mosaic virus (WMV) 2 resistant
		squash (Curcurbita pepo) produced by inserting the coat
		protein (CP) encoding sequences from each of these plant
		viruses into the host genome.
ZW20	Upjohn (USA); Seminis Vegetable	Zucchini yellows mosaic (ZYMV) and watermelon mosaic	Cucurbita pepo (Squash)
	Inc. (Canada)	virus (WMV) 2 resistant squash (Curcurbita pepo)
		produced by inserting the coat protein (CP) encoding
		sequences from each of these plant potyviruses into the
		host genome.
66	Florigene Pty Ltd.	Delayed senescence and sulfonylurea herbicide tolerant	Dianthus
		carnations produced by inserting a truncated copy of the	caryophyllus (Carnation)
		carnation aminocyclopropane cyclase (ACC) synthase
		encoding gene in order to suppress expression of the
		endogenous unmodified gene, which is required for normal
		ethylene biosynthesis. Tolerance to sulfonyl urea herbicides
		was via the introduction of a chlorsulfuron tolerant version
		of the acetolactate synthase (ALS) encoding gene from
		tobacco.
4, 11, 15, 16	Florigene Pty Ltd.	Modified colour and sulfonylurea herbicide tolerant	Dianthus
		carnations produced by inserting two anthocyanin	caryophyllus (Carnation)
		biosynthetic genes whose expression results in a
		violet/mauve colouration. Tolerance to sulfonyl urea
		herbicides was via the introduction of a chlorsulfuron
		tolerant version of the acetolactate synthase (ALS)
		encoding gene from tobacco.
959A, 988A,	Florigene Pty Ltd.	Introduction of two anthocyanin biosynthetic genes to	Dianthus
1226A, 1351A,		result in a violet/mauve colouration; Introduction of a	caryophyllus (Carnation)
1363A, 1400A		variant form of acetolactate synthase (ALS).
A2704-12, A2704-	Aventis CropScience	Glufosinate ammonium herbicide tolerant soybean	Glycine max L. (Soybean)
21, A5547-35		produced by inserting a modified phosphinothricin
		acetyltransferase (PAT) encoding gene from the soil
		bacterium Streptomyces viridochromogenes.
A5547-127	Bayer CropScience (Aventis	Glufosinate ammonium herbicide tolerant soybean	Glycine max L. (Soybean)
	CropScience(AgrEvo))	produced by inserting a modified phosphinothricin
		acetyltransferase (PAT) encoding gene from the soil
		bacterium Streptomyces viridochromogenes.
DP356043	Pioneer Hi-Bred International Inc.	Soybean event with two herbicide tolerance genes:	Glycine max L. (Soybean)
		glyphosate N-acetlytransferase, which detoxifies
		glyphosate, and a modified acetolactate synthase (A
G94-1, G94-19,	DuPont Canada Agricultural	High oleic acid soybean produced by inserting a second	Glycine max L. (Soybean)
G168	Products	copy of the fatty acid desaturase (GmFad2-1) encoding
		gene from soybean, which resulted in “silencing” of the
		endogenous host gene.
GTS 40-3-2	Monsanto Company	Glyphosate tolerant soybean variety produced by inserting	Glycine max L. (Soybean)
		a modified 5-enolpyruvylshikimate-3-phosphate synthase
		(EPSPS) encoding gene from the soil bacterium
		Agrobacterium tumefaciens.
GU262	Bayer CropScience (Aventis	Glufosinate ammonium herbicide tolerant soybean	Glycine max L. (Soybean)
	CropScience(AgrEvo))	produced by inserting a modified phosphinothricin
		acetyltransferase (PAT) encoding gene from the soil
		bacterium Streptomyces viridochromogenes.
MON89788	Monsanto Company	Glyphosate-tolerant soybean produced by inserting a	Glycine max L. (Soybean)
		modified 5-enolpyruvylshikimate-3-phosphate synthase
		(EPSPS) encoding aroA (epsps) gene from Agrobacterium
		tumefaciens CP4.
OT96-15	Agriculture & Agri-Food Canada	Low linolenic acid soybean produced through traditional	Glycine max L. (Soybean)
		cross-breeding to incorporate the novel trait from a
		naturally occurring fan1 gene mutant that was selected for
		low linolenic acid.
W62, W98	Bayer CropScience (Aventis	Glufosinate ammonium herbicide tolerant soybean	Glycine max L. (Soybean)
	CropScience(AgrEvo))	produced by inserting a modified phosphinothricin
		acetyltransferase (PAT) encoding gene from the soil
		bacterium Streptomyces hygroscopicus.
15985	Monsanto Company	Insect resistant cotton derived by transformation of the	Gossypium hirsutum
		DP50B parent variety, which contained event 531	L. (Cotton)
		(expressing Cry1Ac protein), with purified plasmid DNA
		containing the cry2Ab gene from B. thuringiensis subsp.
		kurstaki.
19-51A	DuPont Canada Agricultural	Introduction of a variant form of acetolactate synthase	Gossypium hirsutum
	Products	(ALS).	L. (Cotton)
281-24-236	DOW AgroSciences LLC	Insect-resistant cotton produced by inserting the cry1F gene	Gossypium hirsutum
		from Bacillus thuringiensis var. aizawai. The PAT encoding	L. (Cotton)
		gene from Streptomyces viridochromogenes was
		introduced as a selectable marker.
3006-210-23	DOW AgroSciences LLC	Insect-resistant cotton produced by inserting the cry1Ac	Gossypium hirsutum
		gene from Bacillus thuringiensis subsp. kurstaki. The PAT	L. (Cotton)
		encoding gene from Streptomyces viridochromogenes was
		introduced as a selectable marker.
31807/31808	Calgene Inc.	Insect-resistant and bromoxynil herbicide tolerant cotton	Gossypium hirsutum
		produced by inserting the cry1Ac gene from Bacillus	L. (Cotton)
		thuringiensis and a nitrilase encoding gene from Klebsiella
		pneumoniae.
BXN	Calgene Inc.	Bromoxynil herbicide tolerant cotton produced by inserting	Gossypium hirsutum
		a nitrilase encoding gene from Klebsiella pneumoniae.	L. (Cotton)
COT102	Syngenta Seeds, Inc.	Insect-resistant cotton produced by inserting the vip3A(a)	Gossypium hirsutum
		gene from Bacillus thuringiensis AB88. The APH4	L. (Cotton)
		encoding gene from E. coli was introduced as a selectable
		marker.
DAS-21Ø23-5 ×	DOW AgroSciences LLC	WideStrike ™, a stacked insect-resistant cotton derived	Gossypium hirsutum
DAS-24236-5		from conventional cross-breeding of parental lines 3006-	L. (Cotton)
		210-23 (OECD identifier: DAS-21Ø23-5) and 281-24-236
		(OECD identifier: DAS-24236-5).
DAS-21Ø23-5 ×	DOW AgroSciences LLC and	Stacked insect-resistant and glyphosate-tolerant cotton	Gossypium hirsutum
DAS-24236-5 ×	Pioneer Hi-Bred International Inc.	derived from conventional cross-breeding of WideStrike	L. (Cotton)
MON88913		cotton (OECD identifier: DAS-21Ø23-5 × DAS-24236-5)
		with MON88913, known as RoundupReady Flex (OECD
		identifier: MON-88913-8).
DAS-21Ø23-5 ×	DOW AgroSciences LLC	WideStrike ™/Roundup Ready ® cotton, a stacked insect-	Gossypium hirsutum
DAS-24236-5 ×		resistant and glyphosate-tolerant cotton derived from	L. (Cotton)
MON-Ø1445-2		conventional cross-breeding of WideStrike cotton (OECD
		identifier: DAS-21Ø23-5 × DAS-24236-5) with MON1445
		(OECD identifier: MON-Ø1445-2).
LLCotton25	Bayer CropScience (Aventis	Glufosinate ammonium herbicide tolerant cotton produced	Gossypium hirsutum
	CropScience(AgrEvo))	by inserting a modified phosphinothricin acetyltransferase	L. (Cotton)
		(PAT) encoding gene from the soil bacterium Streptomyces
		hygroscopicus.
LLCotton25 ×	Bayer CropScience (Aventis	Stacked herbicide tolerant and insect resistant cotton	Gossypium hirsutum
MON15985	CropScience(AgrEvo))	combining tolerance to glufosinate ammonium herbicide	L. (Cotton)
		from LLCotton25 (OECD identifier: ACS-GHØØ1-3) with
		resistance to insects from MON15985 (OECD identifier:
		MON-15985-7)
GBH614	Bayer CropScience (Aventis	Glyphosate herbicide tolerant cotton produced by inserting	Gossypium hirsutum
	CropScience(AgrEvo))	2mepsps gene into variety Coker312 by Agrobacterium	L. (Cotton)
		under the control of Ph4a748At and TPotpC
MON1445/1698	Monsanto Company	Glyphosate herbicide tolerant cotton produced by inserting	Gossypium hirsutum
		a naturally glyphosate tolerant form of the enzyme 5-	L. (Cotton)
		enolpyruvyl shikimate-3-phosphate synthase (EPSPS) from
		A. tumefaciens strain CP4.
MON15985 ×	Monsanto Company	Stacked insect resistant and glyphosate tolerant cotton	Gossypium hirsutum
MON88913		produced by conventional cross-breeding of the parental	L. (Cotton)
		lines MON88913 (OECD identifier: MON-88913-8) and
		15985 (OECD identifier: MON-15985-7). Glyphosate
		tolerance is derived from MON88913 which contains two
		genes encoding the enzyme 5-enolypyruvylshikimate-3-
		phosphate synthase (EPSPS) from the CP4 strain of
		Agrobacterium tumefaciens. Insect resistance is derived
		MON15985 which was produced by transformation of the
		DP50B parent variety, which contained event 531
		(expressing Cry1Ac protein), with purified plasmid DNA
		containing the cry2Ab gene from B. thuringiensis subsp.
		kurstaki.
MON-15985-7 ×	Monsanto Company	Stacked insect resistant and herbicide tolerant cotton	Gossypium hirsutum
MON-Ø1445-2		derived from conventional cross-breeding of the parental	L. (Cotton)
		lines 15985 (OECD identifier: MON-15985-7) and
		MON1445 (OECD identifier: MON-Ø1445-2).
MON531/757/1076	Monsanto Company	Insect-resistant cotton produced by inserting the cry1Ac	Gossypium hirsutum
		gene from Bacillus thuringiensis subsp. kurstaki HD-73	L. (Cotton)
		(B.t.k.).
MON88913	Monsanto Company	Glyphosate herbicide tolerant cotton produced by inserting	Gossypium hirsutum
		two genes encoding the enzyme 5-enolypyruvylshikimate-	L. (Cotton)
		3-phosphate synthase (EPSPS) from the CP4 strain of
		Agrobacterium tumefaciens.
MON-ØØ531-6 ×	Monsanto Company	Stacked insect resistant and herbicide tolerant cotton	Gossypium hirsutum
MON-Ø1445-2		derived from conventional cross-breeding of the parental	L. (Cotton)
		lines MON531 (OECD identifier: MON-ØØ531-6) and
		MON1445 (OECD identifier: MON-Ø1445-2).
X81359	BASF Inc.	Tolerance to imidazolinone herbicides by selection of a	Helianthus
		naturally occurring mutant.	annuus (Sunflower)
RH44	BASF Inc.	Selection for a mutagenized version of the enzyme	Lens culinaris (Lentil)
		acetohydroxyacid synthase (AHAS), also known as
		acetolactate synthase (ALS) or acetolactate pyruvate-lyase.
FP967	University of Saskatchewan, Crop	A variant form of acetolactate synthase (ALS) was obtained	Linum usitatissimum
	Dev. Centre	from a chlorsulfuron tolerant line of A. thaliana and used to	L. (Flax, Linseed)
		transform flax.
5345	Monsanto Company	Resistance to lepidopteran pests through the introduction of	Lycopersicon
		the cry1Ac gene from Bacillus thuringiensis subsp.	esculentum (Tomato)
		Kurstaki.
8338	Monsanto Company	Introduction of a gene sequence encoding the enzyme 1-	Lycopersicon
		amino-cyclopropane-1-carboxylic acid deaminase (ACCd)	esculentum (Tomato)
		that metabolizes the precursor of the fruit ripening hormone
		ethylene.
1345-4	DNA Plant Technology	Delayed ripening tomatoes produced by inserting an	Lycopersicon
	Corporation	additional copy of a truncated gene encoding 1-	esculentum (Tomato)
		aminocyclopropane-1-carboxyllic acid (ACC) synthase,
		which resulted in downregulation of the endogenous ACC
		synthase and reduced ethylene accumulation.
35 1 N	Agritope Inc.	Introduction of a gene sequence encoding the enzyme S-	Lycopersicon
		adenosylmethionine hydrolase that metabolizes the	esculentum (Tomato)
		precursor of the fruit ripening hormone ethylene
B, Da, F	Zeneca Seeds	Delayed softening tomatoes produced by inserting a	Lycopersicon
		truncated version of the polygalacturonase (PG) encoding	esculentum (Tomato)
		gene in the sense or anti-sense orientation in order to
		reduce expression of the endogenous PG gene, and thus
		reduce pectin degradation.
FLAVR SAVR	Calgene Inc.	Delayed softening tomatoes produced by inserting an	Lycopersicon
		additional copy of the polygalacturonase (PG) encoding	esculentum (Tomato)
		gene in the anti-sense orientation in order to reduce
		expression of the endogenous PG gene and thus reduce
		pectin degradation.
J101, J163	Monsanto Company and Forage	Glyphosate herbicide tolerant alfalfa (lucerne) produced by	Medicago sativa (Alfalfa)
	Genetics International	inserting a gene encoding the enzyme 5-
		enolypyruvylshikimate-3-phosphate synthase (EPSPS)
		from the CP4 strain of Agrobacterium tumefaciens.
C/F/93/08-02	Societe National d'Exploitation	Tolerance to the herbicides bromoxynil and ioxynil by	Nicotiana tabacum
	des Tabacs et Allumettes	incorporation of the nitrilase gene from Klebsiella	L. (Tobacco)
		pneumoniae.
Vector 21-41	Vector Tobacco Inc.	Reduced nicotine content through introduction of a second	Nicotiana tabacum
		copy of the tobacco quinolinic acid	L. (Tobacco)
		phosphoribosyltransferase (QTPase) in the antisense
		orientation. The NPTII encoding gene from E. coli was
		introduced as a selectable marker to identify transformants.
CL121, CL141,	BASF Inc.	Tolerance to the imidazolinone herbicide, imazethapyr,	Oryza sativa (Rice)
CFX51		induced by chemical mutagenesis of the acetolactate
		synthase (ALS) enzyme using ethyl methanesulfonate
		(EMS).
IMINTA-1,	BASF Inc.	Tolerance to imidazolinone herbicides induced by chemical	Oryza sativa (Rice)
IMINTA-4		mutagenesis of the acetolactate synthase (ALS) enzyme
		using sodium azide.
LLRICE06,	Aventis CropScience	Glufosinate ammonium herbicide tolerant rice produced by	Oryza sativa (Rice)
LLRICE62		inserting a modified phosphinothricin acetyltransferase
		(PAT) encoding gene from the soil bacterium Streptomyces
		hygroscopicus).
LLRICE601	Bayer CropScience (Aventis	Glufosinate ammonium herbicide tolerant rice produced by	Oryza sativa (Rice)
	CropScience(AgrEvo))	inserting a modified phosphinothricin acetyltransferase
		(PAT) encoding gene from the soil bacterium Streptomyces
		hygroscopicus).
C5	United States Department of	Plum pox virus (PPV) resistant plum tree produced through	Prunus domestica (Plum)
	Agriculture - Agricultural	Agrobacterium-mediated transformation with a coat protein
	Research Service	(CP) gene from the virus.
PWC16	BASF Inc.	Tolerance to the imidazolinone herbicide, imazethapyr,	Oryza sativa (Rice)
		induced by chemical mutagenesis of the acetolactate
		synthase (ALS) enzyme using ethyl methanesulfonate
		(EMS).
ATBT04-6,	Monsanto Company	Colorado potato beetle resistant potatoes produced by	Solanum tuberosum
ATBT04-27,		inserting the cry3A gene from Bacillus thuringiensis	L. (Potato)
ATBT04-30,		(subsp. Tenebrionis).
ATBT04-31,
ATBT04-36,
SPBT02-5,
SPBT02-7
BT6, BT10, BT12,	Monsanto Company	Colorado potato beetle resistant potatoes produced by	Solanum tuberosum
BT16, BT17,		inserting the cry3A gene from Bacillus thuringiensis	L. (Potato)
BT18, BT23		(subsp. Tenebrionis).
RBMT15-101,	Monsanto Company	Colorado potato beetle and potato virus Y (PVY) resistant	Solanum tuberosum
SEMT15-02,		potatoes produced by inserting the cry3A gene from	L. (Potato)
SEMT15-15		Bacillus thuringiensis (subsp. Tenebrionis) and the coat
		protein encoding gene from PVY.
RBMT21-129,	Monsanto Company	Colorado potato beetle and potato leafroll virus (PLRV)	Solanum tuberosum
RBMT21-350,		resistant potatoes produced by inserting the cry3A gene	L. (Potato)
RBMT22-082		from Bacillus thuringiensis (subsp. Tenebrionis) and the
		replicase encoding gene from PLRV.
AP205CL	BASF Inc.	Selection for a mutagenized version of the enzyme	Triticum aestivum (Wheat)
		acetohydroxyacid synthase (AHAS), also known as
		acetolactate synthase (ALS) or acetolactate pyruvate-lyase.
AP602CL	BASF Inc.	Selection for a mutagenized version of the enzyme	Triticum aestivum (Wheat)
		acetohydroxyacid synthase (AHAS), also known as
		acetolactate synthase (ALS) or acetolactate pyruvate-lyase.
BW255-2, BW238-3	BASF Inc.	Selection for a mutagenized version of the enzyme	Triticum aestivum (Wheat)
		acetohydroxyacid synthase (AHAS), also known as
		acetolactate synthase (ALS) or acetolactate pyruvate-lyase.
BW7	BASF Inc.	Tolerance to imidazolinone herbicides induced by chemical	Triticum aestivum (Wheat)
		mutagenesis of the acetohydroxyacid synthase (AHAS)
		gene using sodium azide.
MON71800	Monsanto Company	Glyphosate tolerant wheat variety produced by inserting a	Triticum aestivum (Wheat)
		modified 5-enolpyruvylshikimate-3-phosphate synthase
		(EPSPS) encoding gene from the soil bacterium
		Agrobacterium tumefaciens, strain CP4.
SWP965001	Cyanamid Crop Protection	Selection for a mutagenized version of the enzyme	Triticum aestivum (Wheat)
		acetohydroxyacid synthase (AHAS), also known as
		acetolactate synthase (ALS) or acetolactate pyruvate-lyase.
Teal 11A	BASF Inc.	Selection for a mutagenized version of the enzyme	Triticum aestivum (Wheat)
		acetohydroxyacid synthase (AHAS), also known as
		acetolactate synthase (ALS) or acetolactate pyruvate-lyase.
176	Syngenta Seeds, Inc.	Insect-resistant maize produced by inserting the cry1Ab	Zea mays L. (Maize)
		gene from Bacillus thuringiensis subsp. kurstaki. The
		genetic modification affords resistance to attack by the
		European corn borer (ECB).
3751IR	Pioneer Hi-Bred International Inc.	Selection of somaclonal variants by culture of embryos on	Zea mays L. (Maize)
		imidazolinone containing media.
676, 678, 680	Pioneer Hi-Bred International Inc.	Male-sterile and glufosinate ammonium herbicide tolerant	Zea mays L. (Maize)
		maize produced by inserting genes encoding DNA adenine
		methylase and phosphinothricin acetyltransferase (PAT)
		from Escherichia coli and Streptomyces
		viridochromogenes, respectively.
ACS-ZMØØ3-2 ×	Bayer CropScience (Aventis	Stacked insect resistant and herbicide tolerant corn hybrid	Zea mays L. (Maize)
MON-ØØ81Ø-6	CropScience(AgrEvo))	derived from conventional cross-breeding of the parental
		lines T25 (OECD identifier: ACS-ZMØØ3-2) and
		MON810 (OECD identifier: MON-ØØ81Ø-6).
B16 (DLL25)	Dekalb Genetics Corporation	Glufosinate ammonium herbicide tolerant maize produced	Zea mays L. (Maize)
		by inserting the gene encoding phosphinothricin
		acetyltransferase (PAT) from Streptomyces hygroscopicus.
BT11 (X4334CBR,	Syngenta Seeds, Inc.	Insect-resistant and herbicide tolerant maize produced by	Zea mays L. (Maize)
X4734CBR)		inserting the cry1Ab gene from Bacillus thuringiensis
		subsp. kurstaki, and the phosphinothricin N-
		acetyltransferase (PAT) encoding gene from
		S. viridochromogenes.
BT11 × MIR604	Syngenta Seeds, Inc.	Stacked insect resistant and herbicide tolerant maize	Zea mays L. (Maize)
		produced by conventional cross breeding of parental lines
		BT11 (OECD unique identifier: SYN-BTØ11-1) and
		MIR604 (OECD unique identifier: SYN-IR6Ø5-5).
		Resistance to the European Corn Borer and tolerance to the
		herbicide glufosinate ammonium (Liberty) is derived from
		BT11, which contains the cry1Ab gene from Bacillus
		thuringiensis subsp. kurstaki, and the phosphinothricin N-
		acetyltransferase (PAT) encoding gene from
		S. viridochromogenes.
		Corn rootworm-resistance is derived
		from MIR604 which contains the mcry3A gene from
		Bacillus thuringiensis.
BT11 × MIR604 ×	Syngenta Seeds, Inc.	Stacked insect resistant and herbicide tolerant maize	Zea mays L. (Maize)
GA21		produced by conventional cross breeding of parental lines
		BT11 (OECD unique identifier: SYN-BTØ11-1), MIR604
		(OECD unique identifier: SYN-IR6Ø5-5) and GA21
		(OECD unique identifier: MON-ØØØ21-9). Resistance to
		the European Corn Borer and tolerance to the herbicide
		glufosinate ammonium (Liberty) is derived from BT11,
		which contains the cry1Ab gene from Bacillus
		thuringiensis subsp. kurstaki, and the phosphinothricin N-
		acetyltransferase (PAT) encoding gene from
		S. viridochromogenes.
		Corn rootworm-resistance is derived
		from MIR604 which contains the mcry3A gene from
		Bacillus thuringiensis. Tolerance to glyphosate herbcicide
		is derived from GA21 which contains a a modified EPSPS
		gene from maize.
CBH-351	Aventis CropScience	Insect-resistant and glufosinate ammonium herbicide	Zea mays L. (Maize)
		tolerant maize developed by inserting genes encoding
		Cry9C protein from Bacillus thuringiensis subsp tolworthi
		and phosphinothricin acetyltransferase (PAT) from
		Streptomyces hygroscopicus.
DAS-06275-8	DOW AgroSciences LLC	Lepidopteran insect resistant and glufosinate ammonium	Zea mays L. (Maize)
		herbicide-tolerant maize variety produced by inserting the
		cry1F gene from Bacillus thuringiensis var aizawai and the
		phosphinothricin acetyltransferase (PAT) from
		Streptomyces hygroscopicus.
DAS-59122-7	DOW AgroSciences LLC and	Corn rootworm-resistant maize produced by inserting the	Zea mays L. (Maize)
	Pioneer Hi-Bred International Inc.	cry34Ab1 and cry35Ab1 genes from Bacillus thuringiensis
		strain PS149B1. The PAT encoding gene from
		Streptomyces viridochromogenes was introduced as a
		selectable marker.
DAS-59122-7 ×	DOW AgroSciences LLC and	Stacked insect resistant and herbicide tolerant maize	Zea mays L. (Maize)
NK603	Pioneer Hi-Bred International Inc.	produced by conventional cross breeding of parental lines
		DAS-59122-7 (OECD unique identifier: DAS-59122-7)
		with NK603 (OECD unique identifier: MON-ØØ6Ø3-6).
		Corn rootworm-resistance is derived from DAS-59122-7
		which contains the cry34Ab1 and cry35Ab1 genes from
		Bacillus thuringiensis strain PS149B1. Tolerance to
		glyphosate herbcicide is derived from NK603.
DAS-59122-7 ×	DOW AgroSciences LLC and	Stacked insect resistant and herbicide tolerant maize	Zea mays L. (Maize)
TC1507 × NK603	Pioneer Hi-Bred International Inc.	produced by conventional cross breeding of parental lines
		DAS-59122-7 (OECD unique identifier: DAS-59122-7)
		and TC1507 (OECD unique identifier: DAS-Ø15Ø7-1)
		with NK603 (OECD unique identifier: MON-ØØ6Ø3-6).
		Corn rootworm-resistance is derived from DAS-59122-7
		which contains the cry34Ab1 and cry35Ab1 genes from
		Bacillus thuringiensis strain PS149B1. Lepidopteran
		resistance and toleraance to glufosinate ammonium
		herbicide is derived from TC1507. Tolerance to glyphosate
		herbcicide is derived from NK603.
DAS-Ø15Ø7-1 ×	DOW AgroSciences LLC	Stacked insect resistant and herbicide tolerant corn hybrid	Zea mays L. (Maize)
MON-ØØ6Ø3-6		derived from conventional cross-breeding of the parental
		lines 1507 (OECD identifier: DAS-Ø15Ø7-1) and NK603
		(OECD identifier: MON-ØØ6Ø3-6).
DBT418	Dekalb Genetics Corporation	Insect-resistant and glufosinate ammonium herbicide	Zea mays L. (Maize)
		tolerant maize developed by inserting genes encoding
		Cry1AC protein from Bacillus thuringiensis subsp kurstaki
		and phosphinothricin acetyltransferase (PAT) from
		Streptomyces hygroscopicus
DK404SR	BASF Inc.	Somaclonal variants with a modified acetyl-CoA-	Zea mays L. (Maize)
		carboxylase (ACCase) were selected by culture of embryos
		on sethoxydim enriched medium.
Event 3272	Syngenta Seeds, Inc.	Maize line expressing a heat stable alpha-amylase gene	Zea mays L. (Maize)
		amy797E for use in the dry-grind ethanol process. The
		phosphomannose isomerase gene from E. coli was used as a
		selectable marker.
EXP1910IT	Syngenta Seeds, Inc. (formerly	Tolerance to the imidazolinone herbicide, imazethapyr,	Zea mays L. (Maize)
	Zeneca Seeds)	induced by chemical mutagenesis of the acetolactate
		synthase (ALS) enzyme using ethyl methanesulfonate
		(EMS).
GA21	Monsanto Company	Introduction, by particle bombardment, of a modified 5-	Zea mays L. (Maize)
		enolpyruvyl shikimate-3-phosphate synthase (EPSPS), an
		enzyme involved in the shikimate biochemical pathway for
		the production of the aromatic amino acids.
IT	Pioneer Hi-Bred International Inc.	Tolerance to the imidazolinone herbicide, imazethapyr, was	Zea mays L. (Maize)
		obtained by in vitro selection of somaclonal variants.
LY038	Monsanto Company	Altered amino acid composition, specifically elevated	Zea mays L. (Maize)
		levels of lysine, through the introduction of the cordapA
		gene, derived from Corynebacterium glutamicum, encoding
		the enzyme dihydrodipicolinate synthase (cDHDPS).
MIR604	Syngenta Seeds, Inc.	Corn rootworm resistant maize produced by transformation	Zea mays L. (Maize)
		with a modified cry3A gene. The phosphomannose
		isomerase gene from E. coli was used as a selectable
		marker.
MIR604 × GA21	Syngenta Seeds, Inc.	Stacked insect resistant and herbicide tolerant maize	Zea mays L. (Maize)
		produced by conventional cross breeding of parental lines
		MIR604 (OECD unique identifier: SYN-IR6Ø5-5) and
		GA21 (OECD unique identifier: MON-ØØØ21-9). Corn
		rootworm-resistance is derived from MIR604 which
		contains the mcry3A gene from Bacillus thuringiensis.
		Tolerance to glyphosate herbcicide is derived from GA21.
MON80100	Monsanto Company	Insect-resistant maize produced by inserting the cry1Ab	Zea mays L. (Maize)
		gene from Bacillus thuringiensis subsp. kurstaki. The
		genetic modification affords resistance to attack by the
		European corn borer (ECB).
MON802	Monsanto Company	Insect-resistant and glyphosate herbicide tolerant maize	Zea mays L. (Maize)
		produced by inserting the genes encoding the Cry1Ab
		protein from Bacillus thuringiensis and the 5-
		enolpyruvylshikimate-3-phosphate synthase (EPSPS) from
		A. tumefaciens strain CP4.
MON809	Pioneer Hi-Bred International Inc.	Resistance to European corn borer (Ostrinia nubilalis) by	Zea mays L. (Maize)
		introduction of a synthetic cry1Ab gene. Glyphosate
		resistance via introduction of the bacterial version of a
		plant enzyme, 5-enolpyruvyl shikimate-3-phosphate
		synthase (EPSPS).
MON810	Monsanto Company	Insect-resistant maize produced by inserting a truncated	Zea mays L. (Maize)
		form of the cry1Ab gene from Bacillus thuringiensis subsp.
		kurstaki HD-1. The genetic modification affords resistance
		to attack by the European corn borer (ECB).
MON810 ×	Monsanto Company	Stacked insect resistant and glyphosate tolerant maize	Zea mays L. (Maize)
MON88017		derived from conventional cross-breeding of the parental
		lines MON810 (OECD identifier: MON-ØØ81Ø-6) and
		MON88017 (OECD identifier: MON-88Ø17-3). European
		corn borer (ECB) resistance is derived from a truncated
		form of the cry1Ab gene from Bacillus thuringiensis subsp.
		kurstaki HD-1 present in MON810. Corn rootworm
		resistance is derived from the cry3Bb1 gene from Bacillus
		thuringiensis subspecies kumamotoensis strain EG4691
		present in MON88017. Glyphosate tolerance is derived
		from a 5-enolpyruvylshikimate-3-phosphate synthase
		(EPSPS) encoding gene from Agrobacterium tumefaciens
		strain CP4 present in MON88017.
MON832	Monsanto Company	Introduction, by particle bombardment, of glyphosate	Zea mays L. (Maize)
		oxidase (GOX) and a modified 5-enolpyruvyl shikimate-3-
		phosphate synthase (EPSPS), an enzyme involved in the
		shikimate biochemical pathway for the production of the
		aromatic amino acids.
MON863	Monsanto Company	Corn root worm resistant maize produced by inserting the	Zea mays L. (Maize)
		cry3Bb1 gene from Bacillus thuringiensis subsp.
		kumamotoensis.
MON88017	Monsanto Company	Corn rootworm-resistant maize produced by inserting the	Zea mays L. (Maize)
		cry3Bb1 gene from Bacillus thuringiensis subspecies
		kumamotoensis strain EG4691. Glyphosate tolerance
		derived by inserting a 5-enolpyruvylshikimate-3-phosphate
		synthase (EPSPS) encoding gene from Agrobacterium
		tumefaciens strain CP4.
MON89034	Monsanto Company	Maize event expressing two different insecticidal proteins	Zea mays L. (Maize)
		from Bacillus thuringiensis providing resistance to number
		of lepidopteran pests.
MON89034 ×	Monsanto Company	Stacked insect resistant and glyphosate tolerant maize	Zea mays L. (Maize)
MON88017		derived from conventional cross-breeding of the parental
		lines MON89034 (OECD identifier: MON-89Ø34-3) and
		MON88017 (OECD identifier: MON-88Ø17-3). Resistance
		to Lepiopteran insects is derived from two crygenes present
		in MON89043. Corn rootworm resistance is derived from a
		single cry genes and glyphosate tolerance is derived from
		the 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS)
		encoding gene from Agrobacterium tumefaciens present in
		MON88017.
MON-ØØ6Ø3-6 ×	Monsanto Company	Stacked insect resistant and herbicide tolerant corn hybrid	Zea mays L. (Maize)
MON-ØØ81Ø-6		derived from conventional cross-breeding of the parental
		lines NK603 (OECD identifier: MON-ØØ6Ø3-6) and
		MON810 (OECD identifier: MON-ØØ81Ø-6).
MON-ØØ81Ø-6 ×	Monsanto Company	Stacked insect resistant and enhanced lysine content maize	Zea mays L. (Maize)
LY038		derived from conventional cross-breeding of the parental
		lines MON810 (OECD identifier: MON-ØØ81Ø-6) and
		LY038 (OECD identifier: REN-ØØØ38-3).
MON-ØØ863-5 ×	Monsanto Company	Stacked insect resistant and herbicide tolerant corn hybrid	Zea mays L. (Maize)
MON-ØØ6Ø3-6		derived from conventional cross-breeding of the parental
		lines MON863 (OECD identifier: MON-ØØ863-5) and
		NK603 (OECD identifier: MON-ØØ6Ø3-6).
MON-ØØ863-5 ×	Monsanto Company	Stacked insect resistant corn hybrid derived from	Zea mays L. (Maize)
MON-ØØ81Ø-6		conventional cross-breeding of the parental lines MON863
		(OECD identifier: MON-ØØ863-5) and MON810 (OECD
		identifier: MON-ØØ81Ø-6)
MON-ØØ863-5 ×	Monsanto Company	Stacked insect resistant and herbicide tolerant corn hybrid	Zea mays L. (Maize)
MON-ØØ81Ø-6 ×		derived from conventional cross-breeding of the stacked
MON-ØØ6Ø3-6		hybrid MON-ØØ863-5 × MON-ØØ81Ø-6 and NK603
		(OECD identifier: MON-ØØ6Ø3-6).
MON-ØØØ21-9 ×	Monsanto Company	Stacked insect resistant and herbicide tolerant corn hybrid	Zea mays L. (Maize)
MON-ØØ81Ø-6		derived from conventional cross-breeding of the parental
		lines GA21 (OECD identifider: MON-ØØØ21-9) and
		MON810 (OECD identifier: MON-ØØ81Ø-6).
MS3	Bayer CropScience (Aventis	Male sterility caused by expression of the barnase	Zea mays L. (Maize)
	CropScience(AgrEvo))	ribonuclease gene from Bacillus amyloliquefaciens; PPT
		resistance was via PPT-acetyltransferase (PAT).
MS6	Bayer CropScience (Aventis	Male sterility caused by expression of the barnase	Zea mays L. (Maize)
	CropScience(AgrEvo))	ribonuclease gene from Bacillus amyloliquefaciens; PPT
		resistance was via PPT-acetyltransferase (PAT).
NK603	Monsanto Company	Introduction, by particle bombardment, of a modified 5-	Zea mays L. (Maize)
		enolpyruvyl shikimate-3-phosphate synthase (EPSPS), an
		enzyme involved in the shikimate biochemical pathway for
		the production of the aromatic amino acids.
SYN-BTØ11-1 ×	Syngenta Seeds, Inc.	Stacked insect resistant and herbicide tolerant maize	Zea mays L. (Maize)
MON-ØØØ21-9		produced by conventional cross breeding of parental lines
		BT11 (OECD unique identifier: SYN-BTØ11-1) and GA21
		(OECD unique identifier: MON-ØØØ21-9).
T14, T25	Bayer CropScience (Aventis	Glufosinate herbicide tolerant maize produced by inserting	Zea mays L. (Maize)
	CropScience(AgrEvo))	the phosphinothricin N-acetyltransferase (PAT) encoding
		gene from the aerobic actinomycete Streptomyces
		viridochromogenes.
TC1507	Mycogen (c/o Dow	Insect-resistant and glufosinate ammonium herbicide	Zea mays L. (Maize)
	AgroSciences); Pioneer (c/o	tolerant maize produced by inserting the cry1F gene from
	Dupont)	Bacillus thuringiensis var. aizawai and the phosphinothricin
		N-acetyltransferase encoding gene from Streptomyces
		viridochromogenes.
TC1507 × DAS-	DOW AgroSciences LLC and	Stacked insect resistant and herbicide tolerant maize	Zea mays L. (Maize)
59122-7	Pioneer Hi-Bred International Inc.	produced by conventional cross breeding of parental lines
		TC1507 (OECD unique identifier: DAS-Ø15Ø7-1) with
		DAS-59122-7 (OECD unique identifier: DAS-59122-7).
		Resistance to lepidopteran insects is derived from TC1507
		due the presence of the cry1F gene from Bacillus
		thuringiensis var. aizawai. Corn rootworm-resistance is
		derived from DAS-59122-7 which contains the cry34Ab1
		and cry35Ab1 genes from Bacillus thuringiensis strain
		PS149B1. Tolerance to glufosinate ammonium herbcicide
		is derived from TC1507 from the phosphinothricin N-
		acetyltransferase encoding gene from Streptomyces
		viridochromogenes.
DP-Ø9814Ø-6	Pioneer Hi-Bred International Inc.	Corn line 98140 was genetically engineered to express the	Zea mays L. (Maize)
(Event 98140)		GAT4621 (glyphosate acetyltransferase) and ZM-HRA
		(modified version of a maize acetolactate synthase)
		proteins. The GAT4621 protein, encoded by the gat4621
		gene, confers tolerance to glyphosate-containing herbicides
		by acetylating glyphosate and thereby rendering it non-
		phytotoxic. The ZM-HRA protein, encoded by the zm-hra
		gene, confers tolerance to the ALS-inhibiting class of
		herbicides.

A further aspect of the instant invention is a method of protecting natural substances of vegetable or animal origin or their processed forms, which have been taken from the natural life cycle, which comprises applying to said natural substances of vegetable or animal origin or their processed forms a combination of compounds (A) and (B) in a synergistically effective amount.

A preferred embodiment is a method of protecting natural substances of vegetable origin or their processed forms, which have been taken from the natural life cycle, which comprises applying to said natural substances of vegetable origin or their processed forms a combination of compounds (A) and (B) in a synergistically effective amount.

A further preferred embodiment is a method of protecting fruit, preferably pomes, stone fruits, soft fruits and citrus fruits, or their processed forms, which have been taken from the natural life cycle, which comprises applying to said natural substances of vegetable origin or their processed forms a combination of compounds (A) and (B) in a synergistically effective amount.

The combinations or compositions of the present invention may also be used in the field of protecting technical material against attack of fungi. According to the instant invention, the term “technical material” includes paper; carpets; constructions; cooling and heating systems; wall-boards; ventilation and air conditioning systems and the like. The combinations according the present invention can prevent disadvantageous effects such as decay, discoloration or mold. Preferably “storage goods” is understood to denote wall-boards.

The method of treatment according to the invention can also be used in the field of protecting storage goods against attack of fungi. According to the instant invention, the term “storage goods” is understood to denote natural substances of vegetable or animal origin and their processed forms, which have been taken from the natural life cycle and for which long-term protection is desired. Storage goods of vegetable origin, such as plants or parts thereof, for example stalks, leafs, tubers, seeds, fruits or grains, can be protected in the freshly harvested state or in processed form, such as pre-dried, moistened, comminuted, ground, pressed or roasted. Also falling under the definition of storage goods is timber, whether in the form of crude timber, such as construction timber, electricity pylons and barriers, or in the form of finished articles, such as furniture or objects made from wood. Storage goods of animal origin are hides, leather, furs, hairs and the like. The combinations according the present invention can prevent disadvantageous effects such as decay, discoloration or mold. Preferably “storage goods” is understood to denote natural substances of vegetable origin and their processed forms, more preferably fruits and their processed forms, such as pomes, stone fruits, soft fruits and citrus fruits and their processed forms.

In another preferred embodiment of the invention “storage goods” is understood to denote wood. The fungicide combination or composition according to the invention may also be used against fungal diseases liable to grow on or inside timber. The term “timber” means all types of species of wood, and all types of working of this wood intended for construction, for example solid wood, high-density wood, laminated wood, and plywood. The method for treating timber according to the invention mainly consists in contacting one or more compounds according to the invention, or a composition according to the invention; this includes for example direct application, spraying, dipping, injection or any other suitable means.

Numerous fungi are serious pests of economically important agricultural crops. Further, crop contamination by fungal toxins is a major problem for agriculture throughout the world.

Mycotoxins, such as aflatoxins, ochratoxins, patulin, fumonisins, zearalenones, and trichothecenes, are toxic fungal metabolites, often found in agricultural products that are characterized by their ability to cause health problems for humans and vertebrates. They are produced for example by different Fusarium and Aspergillus, Penicillium and Alternaria species.

Aflatoxins are toxins produced by Aspergillus species that grow on several crops, in particular on maize or corn before and after harvest of the crop as well as during storage. The biosynthesis of aflatoxins involves a complex polyketide pathway starting with acetate and malonate. One important intermediate is sterigmatocystin and O-methylsterigmatocystin which are direct precursors of aflatoxins. Important producers of aflatoxins are Aspergillus flavus, most strains of Aspergillus parasiticus, Aspergillus nomius, Aspergillus bombycis, Aspergillus pseudotamarii, Aspergillus ochraceoroseus, Aspergillus rambelli, Emericella astellata, Emericella venezuelensis, Bipolaris spp., Chaetomium spp., Farrowia spp., and Monocillium spp., in particular Aspergillus flavus and Aspergillus parasiticus (Plant Breeding (1999), 118, pp 1-16). There are also additional Aspergillus species known. The group of aflatoxins consists of more than 20 different toxins, in particular aflatoxin B1, B2, G1 and G2, cyclopiazonic acid (CPA).

Ochratoxins are mycotoxins produced by some Aspergillus species and Penicilium species, like A. ochraceus, A. carbonarius or P. viridicatum, Examples for Ochratoxins are ochratoxin A, B, and C. Ochratoxin A is the most prevalent and relevant fungal toxin of this group.

Fumonisins are toxins produced by Fusarium species that grow on several crops, mainly corn, before and after harvest of the crop as well as during storage. The diseases, Fusarium kernel, ear and stalk rot of corn, is caused by Fusarium verticillioides, F. subglutinans, F. moniliforme, and F. prolifeatum. The main mycotoxins of these species are the fumonisins, of which more than ten chemical forms have been isolated. Examples for fumonisins are FB1, FB2 and FB3. In addition the above mentioned Fusarium species of corn can also produce the mycotoxins moniliformin and beauvericin. In particular Fusarium verticillioides is mentioned as an important pathogen of corn, this Fusarium species produces as the main mycotoxin fumonisins of the B-type.

Trichothecenes are those mycotoxins of primary concern which can be found in Fusarium diseases of small grain cereals like wheat, barley, rye, triticale, rice, sorghum and oat. They are sesquiterpene epoxide mycotoxins produced by species of Fusarium, Trichothecium, and Myrothecium and act as potent inhibitors of eukaryotic protein synthesis.

Some of these trichothecene producing Fusarium species also infect corn or maize.

Examples of trichothecene mycotoxins include T-2 toxin, HT-2 toxin, isotrichodermol, DAS, 3-deacetylcalonectrin, 3,15-dideacetylcalonectrin, scirpentriol, neosolaniol; 15-acetyldeoxynivalenol, 3-acetyldeoxynivalenol, nivalenol, 4-acetylnivalenol (fusarenone-X), 4,15-diacetylnivalenol, 4,7,15-acetylnivalenol, and deoxynivalenol (hereinafter “DON”) and their various acetylated derivatives. The most common trichothecene in Fusarium head blight is DON produced for example by Fusarium graminearum and F. culmorum.

Another mycotoxin mainly produced by F. culmorum, F. graminearum and F. cerealis is zearalenone, a phenolic resorcyclic acid lactone that is primarily an estrogenic fungal metabolite.

Fusarium species that produce mycotoxins, such as fumonisins and trichothecenes, include F. acuminatum, F. crookwellense, F., verticillioides, F. culmorum, F. avenaceum, F. equiseti, F. moniliforme, F, graminearnum (Gibberella zeae), F. lateritium, F. pose, F. sambucinum (G. pulicaris), F. proliferatum, F. subglutinans, F. sporotrichioides and other Fusarium species.

In contrast the species Microdochium nivale also a member of the so-called Fusarium complex is known to not produce any mycotoxins.

Both acute and chronic mycotoxicoses in farm animals and in humans have been associated with consumption of wheat, rye, barley, oats, rice and maize contaminated with Fusarium species that produce trichothecene mycotoxins. Experiments with chemically pure trichothecenes at low dosage levels have reproduced many of the features observed in moldy grain toxicoses in animals, including anemia and immunosuppression, haemorrage, emesis and feed refusal. Historical and epidemiological data from human populations indicate an association between certain disease epidemics and consumption of grain infected with Fusarium species that produce trichothecenes. In particular, outbreaks of a fatal disease known as alimentary toxic aleukia, which has occurred in Russia since the nineteenth century, have been associated with consumption of over-wintered grains contaminated with Fusarium species that produce the trichothecene T-2 toxin. In Japan, outbreaks of a similar disease called akakabi-byo or red mold disease have been associated with grain infected with Fusarium species that produce the trichothecene, DON. Trichothecenes were detected in the toxic grain samples responsible for recent human disease outbreaks in India and Japan. There exists, therefore, a need for agricultural methods for preventing, and crops having reduced levels of, mycotoxin contamination.

Further, mycotoxin-producing Fusarium species are destructive pathogens and attack a wide range of plant species. The acute phytotoxicity of mycotoxins and their occurrence in plant tissues also suggests that these mycotoxins play a role in the pathogenesis of Fusarium on plants. This implies that mycotoxins play a role in disease and, therefore, reducing their toxicity to the plant may also prevent or reduce disease in the plant. Further, reduction in disease levels may have the additional benefit of reducing mycotoxin contamination on the plant and particularly in grain where the plant is a cereal plant.

Among the diseases of plants or crops that can be controlled by the method according to the invention, mention may be made of:

Powdery Mildew Diseases Such as

Blumeria diseases caused for example by Blumeria graminis
Podosphaera diseases caused for example by Podosphaera leucotricha
Sphaerotheca diseases caused for example by Sphaerotheca fuliginea
Uncinula diseases caused for example by Uncinula necator

Rust Diseases Such as

Gymnosporangium diseases caused for example by Gymnosporangium sabinae
Hemileia diseases caused for example by Hemileia vastatrix
Phakopsora diseases caused for example by Phakopsora pachyrhizi and Phakopsora meibomiae
Puccinia diseases caused for example by Puccinia recondite, and Puccinia triticina;
Uromyces diseases caused for example by Uromyces appendiculatus

Oomycete Diseases Such as

Bremia diseases caused for example by Bremia lactucae
Peronospora diseases caused for example by Peronospora pisi and Peronospora brassicae
Phytophthora diseases caused for example by Phytophthora infestans
Plasmopara diseases caused for example by Plasmopara viticola
Pseudoperonospora diseases caused for example by Pseudoperonospora humuli and Pseudoperonospora cubensis
Pythium diseases caused for example by Pythium ultimum

Leafspot, Leaf Blotch and Leaf Blight Diseases Such as

Alternaria diseases caused for example by Alternaria solani
Cercospora diseases caused for example by Cercospora beticola
Cladiosporium diseases caused for example by Cladiosporium cucumerinum
Cochliobolus diseases caused for example by Cochliobolus sativus (Conidiaform: Drechslera, Syn: Helminthosporium);
Colletotrichum diseases caused for example by Colletotrichum lindemuthianum
Cycloconium diseases caused for example by Cycloconium oleaginum
Diaporthe diseases caused for example by Diaporthe citri
Elsinoe diseases caused for example by Elsinoe fawcettii
Gloeosporium diseases caused for example by Gloeosporium laeticolor
Glomerella diseases caused for example by Glomerella cingulata
Guignardia diseases caused for example by Guignardia bidwellii
Leptosphaeria diseases caused for example by Leptosphaeria maculans
Magnaporthe diseases caused for example by Magnaporthe grisea
Mycosphaerella diseases caused for example by Mycosphaerella graminicola and Mycosphaerella fijiensis
Phaeosphaeria diseases caused for example by Phaeosphaeria nodorum
Pyrenophora diseases caused for example by Pyrenophora teres
Ramularia diseases caused for example by Ramularia collo-cygni
Rhynchosporium diseases caused for example by Rhynchosporium secalis
Septoria diseases caused for example by Septoria apii;
Typhula diseases caused for example by Thyphula incarnata
Venturia diseases caused for example by Venturia inaequalis

Root- and Stem Diseases Such as

Corticium diseases caused for example by Corticium graminearum
Fusarium diseases caused for example by Fusarium oxysporum
Gaeumannomyces diseases caused for example by Gacumannomyces graminis
Rhizoctonia diseases caused for example by Rhizoctonia solani
Oculimacula (Tapesia) diseases caused for example by Oculimacula Tapesia acuformis
Thielaviopsis diseases caused for example by Thielaviopsis basicola

Ear and Panicle Diseases Including Maize Cob Such as

Alternaria diseases caused for example by Alternaria spp.
Aspergillus diseases caused for example by Aspergillus flavus
Cladosporium diseases caused for example by Cladiosporium cladosporioides
Claviceps diseases caused for example by Claviceps purpurea
Fusarium diseases caused for example by Fusarium culmorum
Gibberella diseases caused for example by Gibberella zeae
Monographella diseases caused for example by Monographella nivalis

Smut- and Bunt Diseases Such as

Sphacelotheca diseases caused for example by Sphacelotheca reiliana
Tilletia diseases caused for example by Tilletia caries
Urocystis diseases Urocystis occulta
Ustilago diseases caused for example by Ustilago nuda;

Fruit Rot and Mould Diseases Such as

Aspergillus diseases caused for example by Aspergillus flavus
Botrytis diseases caused for example by Botrytis cinerea
Penicillium diseases caused for example by Penicillium expansum and Penicillium purpurogenum
Sclerotinia diseases caused for example by Sclerotinia sclerotiorum;
Verticillium diseases caused for example by Verticillium alboatrum

Seed- and Soilborne Decay, Mould, Wilt, Rot and Damping-Off Diseases

Fusarium diseases caused for example by Fusarium culmorum
Phytophthora diseases caused for example by Phytophthora cactorum
Pythium diseases caused for example by Pythium ultimum
Rhizoctonia diseases caused for example by Rhizoctonia solani
Sclerotium diseases caused for example by Sclerotium rolfsii

Canker, Broom and Dieback Diseases Such as

Nectria diseases caused for example by Nectria galligena

Blight Diseases Such as

Monilinia diseases caused for example by Monilinia laxa

Leaf Blister or Leaf Curl Diseases Including Deformation of Blooms and Fruits Such as

Taphrina diseases caused for example by Taphrina deformans

Decline Diseases of Wooden Plants Such as

Esca disease caused for example by Phaeomoniella clamydospora and Phaeoacremonium aleophilum and Fomitiporia mediterranea

Diseases of Flowers and Seeds Such as

Botrytis diseases caused for example by Botrytis cinerma

Diseases of Tubers Such as

Rhizoctonia diseases caused for example by Rhizoctonia solani
Helminthosporium diseases caused for example by Helminthosporium solani
Diseases caused by Bacterial Organisms Such as
Xanthomanas species for example Xanthomonas campestris pv. Oryzae
Pseudomonas species for example Pseudomonas syringae pv. Lachrymans
Erwinia species for example Erwinia amylovora.

The active compound combinations or compositions related to this invention are preferably used to control the following diseases:

Aspergillus flavus, most strains of Aspergillus parasiticus, Aspergillus nomius, Aspergillus bombycis, Aspergillus pseudotamarii, Aspergillus ochraceoroseus, Aspergillus rambelli, Emericella astellata, Emericella venezuelensis, Bipolaris spp., Chaetomium spp., Farrowia spp., and Monocillium spp., in particular Aspergillus flavus and Aspergillus parasiticus, Fusarium graminearum, Fusarium culmorum, Fusarium cerealis Fusarium acuminatum, Fusarium crookwellense, Fusarium verticillioides, Fusarium culmorum, Fusarium avenaceum, Fusarium equiseti, Fusarium moniliforme, Fusarium graminearum (Gibberella zeae), Fusarium lateritium, Fusarium poae, Fusarium sambucinum (G. pulicaris), Fusarium proliferatum, Fusarium subglutinans, Fusarium sporotrichioides and other Fusarium species.

The method of treatment according to the invention also provides the use of compounds (A) and (B) in a simultaneous, separate or sequential manner.

The dose of active compound usually applied in the method of treatment according to the invention is generally and advantageously

• • for foliar treatments: from 0.1 to 10,000 g/ha, preferably from 10 to 1,000 g/ha, more preferably from 50 to 300 g/ha; in case of drench or drip application, the dose can even be reduced, especially while using inert substrates like rockwool or perlite;
  • for seed treatment: from 2 to 200 g per 100 kilogram of seed, preferably from 3 to 150 g per 100 kilogram of seed;
  • for soil treatment: from 0.1 to 10,000 g/ha, preferably from 1 to 5,000 g/ha.

The doses herein indicated are given as illustrative examples of the method according to the invention. A person skilled in the art will know how to adapt the application doses, notably according to the nature of the plant or crop to be treated.

The compounds or mixtures according to the invention may also be used for the preparation of composition useful to curatively or preventively treat human or animal fungal diseases such as, for example, mycoses, dermatoses, trichophyton diseases and candidiases or diseases caused by Aspergillus spp., for example Aspergillus fumigatus.

Treatment of Seeds

The invention comprises a procedure in which the seed is treated at the same time with a compound of Group (A) and a compound selected from group (B). It further comprises a method in which the seed is treated with compound of Group (A) and a compound selected from group (B) separately.

The invention also comprises a seed, which has been treated with a compound of Group (A) and a compound selected from group (B) at the same time. The invention also comprises a seed, which has been treated with a compound of Group (A) and a compound selected from group (B) separately. For the latter seed, the active ingredients can be applied in separate layers. These layers can optionally be separated by an additional layer that may or may not contain an active ingredient.

The mixtures of the invention are particularly suitable for the treatment of seeds. A large part of the damage caused by pests on cultigens occurs by infestation of the seed during storage and after sowing the seed in the ground as well as during and after germination of the plants. This phase is especially critical since the roots and shoots of the growing plant are particularly sensitive and even a small amount of damage can lead to withering of the whole plant. There is therefore considerable interest in protecting the seed and the germinating plant by the use of suitable agents.

The control of pests by treatment of the seeds of plants has been known for a considerable time and is the object of continuous improvement. However, there are a number of problems in the treatment of seed that cannot always be satisfactorily solved. Therefore it is worthwhile to develop methods for the protection of seeds and germinating plants which makes the additional application of plant protection agents after seeding or after germination of the plants superfluous. It is further worthwhile to optimize the amount of the applied active material such that the seed and the germinating plants are protected against infestation by pests as best as possible without the plants themselves being damaged by the active compound applied. In particular, methods for the treatment seed should also take into account the intrinsic insecticidal properties of transgenic plants in order to achieve optimal protection of the seed and germinating plants with a minimal expenditure of plant protection agents.

The present invention relates therefore especially to a method for the protection of seed and germinating plants from infestation with pests in that the seed is treated with the combination/composition of the invention. In addition the invention relates also to the use of the combination/composition of the invention for the treatment seed for protection of the seed and the germinating plants from pests. Furthermore the invention relates to seed which was treated with an combination/composition of the invention for protection from pests.

One of the advantages of the invention is because of the special systemic properties of the combination/composition of the invention treatment with these combination/composition protects not only the seed itself from pests but also the plants emerging after sprouting. In this way the direct treatment of the culture at the time of sowing or shortly thereafter can be omitted.

A further advantage is the synergistic increase in insecticidal activity of the combination/composition of the invention in comparison to the respective individual active compounds, which extends beyond the sum of the activity of both individually applied active compounds. In this way an optimization of the amount of active compound applied is made possible.

It is also be regarded as advantageous that the mixtures of the invention can also be used in particular with transgenic seeds whereby the plants emerging from this seed are capable of the expression of a protein directed against pests. By treatment of such seed with the agents of the invention certain pests can already be controlled by expression of the, for example, insecticidal protein, and it is additionally surprising that a synergistic activity supplementation occurs with the agents of the invention, which improves still further the effectiveness of the protection from pest infestation.

The agents of the invention are suitable for the protection of seed of plant varieties of all types as already described which are used in agriculture, in greenhouses, in forestry, in garden construction or in vineyards. In particular, this concerns seed of maize, peanut, canola, rape, poppy, olive, coconut, cacao, soy, cotton, beet, (e.g. sugar beet and feed beet), rice, millet, wheat, barley, oats, rye, sunflower, sugar cane or tobacco. The combination/compositions of the invention are also suitable for the treatment of the seed of fruit plants and vegetables as previously described. Particular importance is attached to the treatment of the seed of maize, soy, cotton, wheat and canola or rape.

As already described, the treatment of transgenic seed with a combination/composition of the invention is of particular importance. This concerns the seeds of plants which generally contain at least one heterologous gene that controls the expression of a polypeptide with special insecticidal properties. The heterologous gene in transgenic seed can originate from microorganisms such as Bacillus, Rhizobium, Pseudomonas, Serratia, Trichoderma, Clavibacter, Glomus or Gliocladium. The present invention is particularly suitable for the treatment of transgenic seed that contains at least one heterologous gene that originates from Bacillus sp. and whose gene product exhibits activity against the European corn borer and/or western corn rootworm. Particularly preferred is a heterologous gene that originates from Bacillus thuringiensis.

Within the context of the present invention the combination/composition of the invention is applied to the seed alone or in a suitable formulation. Preferably the seed is handled in a state in which it is so stable, that no damage occurs during treatment. In general treatment of the seed can be carried out at any time between harvest and sowing. Normally seed is used that was separated from the plant and has been freed of spadix, husks, stalks, pods, wool or fruit flesh. Use of seed that was harvested, purified, and dried to moisture content of below 15% w/w. Alternatively, seed treated with water after drying and then dried again can also be used.

In general care must be taken during the treatment of the seed that the amount of the combination/composition of the invention and/or further additive applied to the seed is so chosen that the germination of the seed is not impaired and the emerging plant is not damaged. This is to be noted above all with active compounds which can show phytotoxic effects when applied in certain amounts.

The combination/compositions of the invention can be applied directly, that is without containing additional components and without being diluted. It is normally preferred to apply the combination/composition to the seed in the form of a suitable formulation. Suitable formulations and methods for seed treatment are known to the person skilled in the art.

According to another aspect of the present invention, in the combination or composition according to the invention, the compound ratio A/B may be advantageously chosen so as to produce a synergistic effect. The term synergistic effect is understood to mean in particular that defined by Colby in an article entitled “Calculation of the synergistic and antagonistic responses of herbicide combinations” Weeds, (1967), 15, pages 20-22.

The latter article mentions the formula:

$E=X+Y-\frac{\mathrm{XY}}{100}$

wherein E represents the expected percentage of inhibition of the pest for the combination of the two compounds at defined doses (for example equal to x and y respectively), X is the percentage of inhibition observed for the pest by compound (A) at a defined dose (equal to x), Y is the percentage of inhibition observed for the pest by compound (B) at a defined dose (equal to y). When the percentage of inhibition observed for the combination is greater than E, there is a synergistic effect.

The term “synergistic effect” also means the effect defined by application of the Tammes method, “Isoboles, a graphic representation of synergism in pesticides”, Netherlands Journal of Plant Pathology, 70 (1964), pages 73-80.

BIOLOGICAL EXAMPLES

Here, the efficacy is determined in %. 0% means an efficacy which corresponds to that of the control, whereas an efficacy of 100% means that no infection is observed.

If the actual fungicidal action exceeds the calculated value, the action of the combination is superadditive, i.e. a synergistic effect is present. In this case, the actually observed efficacy must exceed the value calculated using the above formula for the expected efficacy (E).

The invention is illustrated by the examples below. However, the invention is not limited to the examples.

Example A

Pyrenophora teres-Test (Barley)/Preventive

Solvent: 49 parts by weight of n,n-dimethylacadd
Emulsifier: 1 part by weight of alkylaryl polyglycol ether

To produce a suitable preparation of active compound, 1 part by weight of active compound or active compound combination is mixed with the stated amounts of solvent and emulsifier, and the concentrate is diluted with water to the desired concentration.

To test for preventive activity, young plants are sprayed with the preparation of active compound or active compound combination at the stated rate of application.

After the spray coating has been dried, the plants are sprayed with a spore suspension of Pyrenophora teres. The plants remain for 48 hours in an incubation cabinet at approximately 20° C. and a relative atmospheric humidity of approximately 100%.

The plants are placed in the greenhouse at a temperature of approximately 20° C. and a relative atmospheric humidity of approximately 80%.

The test is evaluated 8 days after the inoculation. 0% means an efficacy which corresponds to that of the control, while an efficacy of 100% means that no disease is observed.

TABLE A
Pyrenophora teres-test (barley)/preventive
		Application
	Ratio	rate of active
	of	compound in	Efficacy in %
Active compounds	mixture	g/ha	found*	calc.**
		62.5	40
		125	70
I-a + 1.41	}	1:2	62.5 + 125	100	82
*found = activity found
**calc. = activity calculated using Colby[3 s formula

Example B

Blumeria Test (Barley)/Preventive

Solvent: 49 parts by weight of n,n-dimethylacetamid
Emulsifier: 1 part by weight of alkylaryl polyglycol ether

To produce a suitable preparation of active compound, 1 part by weight of active compound or active compound combination is mixed with the stated amounts of solvent and emulsifier, and the concentrate is diluted with water to the desired concentration.

To test for preventive activity, young plants are sprayed with the preparation of active compound or active compound combination at the stated rate of application.

After the spray coating has been dried, the plants are dusted with spores of Blumeria gramiais f.sp. hordel.

The plants are placed in the greenhouse at a temperature of approximately 18° C. and a relative atmospheric humidity of approximately 80% to promote the development of mildew pustules.

The test is evaluated 7 days after the inoculation. 0% means an efficacy which corresponds to that of the control, while an efficacy of 100% means that no disease is observed.

TABLE B
Blumeria-test (barley)/preventative
		Application
		rate of active
	Ratio of	compound in	Efficacy in %
Active compounds	mixture	g/ha	found*	calc.**
		62.5	40
		62.5	80
I-a + 3.17	}	1:1	62.5 + 62.5	100	88
*found = activity found
**calc. = activity calculated using Colby's formula

TABLE C
Blumeria-test (barley)/preventive
		Application
		rate of active
	Ratio of	compound in	Efficacy in %
Active compounds	mixture	g/ha	found*	calc.**
		62.5	40
		62.5	10
I-a + 2.2	}	1:1	62.5 + 62.5	100	46
*found = activity found
**calc. = activity calculated using Colby's formula

Claims

1. A composition comprising

(A) at least one compound according to formula (I)

wherein

R1 is selected from the group consisting of hydrogen-a mercapto- (—SH) and a methyl group;

R2 is selected from the group consisting of a methyl- and an ethyl group;

R3 is selected from the group consisting of a methyl-, an ethyl- and an isopropyl group;

or alternatively R2 and R3 can form, together with the N-atom to which they are attached, a piperidyl-, a pyrrolidyl- or a 2,6-dimethylmorpholinyl-ring;

R4 is selected from the group consisting of a chlorine- or a fluorine atom, a trifluoromethyl-, a difluoromethyl- and a methyl group;

R5 and R6 independently from each other, are selected from the group consisting of a hydrogen atom, a methyl- and an ethyl group; or can form, together with the C-atom to which they are attached, a cyclopropyl ring;

R7 is selected from the group consisting of a chlorine atom, a tert-butyl-, a methoxy-, an ethoxy-, a trimethylsilyl- and a triethylsilyl-group,

n is 1

or salts or stereoisomers thereof,

and

(B-I) at least one further active compound selected from the group consisting of (B-I.2) inhibitors of the respiratory chain at complex I or II, (B-I.3) inhibitors of the respiratory chain at complex III, (B-I.4) Inhibitors of the mitosis and cell division, (B-I.5) Compounds capable to have a multisite action, (B-I.6) Compounds capable to induce a host defence, (B-I.7) Inhibitors of the amino acid and/or protein biosynthesis, (B-I.8) Inhibitors of the ATP production, (B-I.9) Inhibitors of the cell wall synthesis, (B-I.10) Inhibitors of the lipid and membrane synthesis, (B-I.11) Inhibitors of the melanine biosynthesis, (B-I.12) Inhibitors of the nucleic acid synthesis, (B-I.13) Inhibitors of the signal transduction, (B-I.14) Compounds capable to act as an uncoupler, and (B-I.15) Further compounds

or

(B-II) at least one further insecticidally active compound, selected from the group consisting of (B-II.1) Acetylcholinesterase (AChE) inhibitors, (B-II.2) GABA-gated chloride channel antagonists, (B-II.3) Sodium channel modulators/voltage-dependent sodium channel blockers, (B-II.4) Nicotinergic acetylcholine receptor agonists, (B-II.5) Allosteric acetylcholine receptor modulators (agonists), (B-II.6) Chloride channel activators, (B-II.7) Juvenile hormone mimics, (B-II.8) Miscellaneous non-specific (multi-site) inhibitors, (B-II.9) Selective homopteran feeding blockers, (B-II.10) Mite growth inhibitors, (B-II.11) Microbial disruptors of insect midgut membranes, (B-II.12) Inhibitors of mitochondrial ATP synthase, (B-II.13) Uncouplers of oxidative phoshorylation via disruption of the proton gradient, (B-II.14) Nicotinic acetylcholine receptor channel blockers, (B-II.15) Inhibitors of chitin biosynthesis, type 0, (B-II.16) Inhibitors of chitin biosynthesis, type 1, (B-II.17) Moulting disruptors, (B-II.18) Ecdysone receptor agonists/disruptors, (B-II.19) Octopamine receptor agonists, (B-II.20) Mitochondrial complex III electron transport inhibitors, (B-II.21) Mitochondrial complex I electron transport inhibitors, (B-II.22) Voltage-dependent sodium channel blockers, (B-II.23) Inhibitors of acetyl CoA carboxylase, (B-II.24) Mitochondrial complex IV electron inhibitors, (B-II.25) Mitochondrial complex II electron transport inhibitors, (B-II.28) Ryanodine receptor modulators,

or (B-III) at least one compound having plant growth regulating activity, selected from the group consisting of (B-III.1) antiauxines, (B-III.2) auxines, (B-III.3) cytokinines, (B-III.4) defoliating agents, (B-III.5) ethylene inhibitors, (B-III.6) ethylene generators, (B-III.7) gibberellines, (B-III.8) abscisinic acid, ancymidol, butralin, carbaryl, chlorphonium or its chloride, chlorpropham, dikegulac, dikegulac-sodium, flumetralin, fluoridamide, fosamine, glyphosine, isopyrimol, jasmonic acid, maleic acid hydrazide or its potassium salt, mepiquat or its chloride, piproctanyl or its bromide, prohydrojasmon, propham, 2,3,5-tri-iodobenzoic acid, 2,6-diisopropylnaphthaline, cloprop, 1-naphthylacetic acid ethylester, isoprothiolane, MCPB-ethyl [4-4-chloro-o-tolyloxy)butyric acid ethylester], N-acetylthiazolidine-4-carboxylic acid, n-decanol, pelargonic acid, N-phenylphthaliminic acid, tecnazene, triacontanol, 2,3-dihydro-5,6-diphenyl-1,4-oxathiin, 2-cyano-3-(2,4-dichlorophenyl)acrylic acid, 2-hydrazinoethanol, alorac, amidochlor, BTS 44584 [dimethyl(4-piperidinocarbonyloxy-2,5-xylyl)sulfonium-toluen-4-sulfonat], chloramben, chlorfluren, chlorfluren-methyl, dicamba-methyl, dichlorflurenol, dichlorflurenol-methyl, dimexano, etacelasil, hexafluoraceton-trihydrat, N-(2-ethyl-2H-pyrazol-3-yl)-N′-phenylurea, N-m-tolylphthalaminic acid, N-Pyrrolidinosuccinaminic acid, 3-tert-Butylphenoxyacetic acid propylester, pydanon, sodium (Z)-3-chloracrylate, (B-III.9) morphactines, (B-III.10) plant growth retarders/modifiers, (B-III.11) plant growth stimulators, (B-III.12) benzofluor, buminafos, carvone, ciobutide, clofencet, clofence-potassium, cloxyfonac, cloxyfonac-sodium, cyclanilide, cycloheximide, epocholeone, ethylchlozate, ethylene, fenridazon, heptopargil, holosulf, inabenfide, karetazan, lead arsenate, methasulfocarb, prohexadione, prohexadione-Calcium, pydanon, sintofen, triapenthenol, trinexapac and trinexapac-ethyl.

2. The composition according to claim 1, wherein the at least one compound of formula (I) is the compound of formula (Ia)

3. The composition according to claim 1 wherein the at least one further active compound (B-I) is selected from the group consisting of Cyproconazole, Epoxiconazole, Flusilazole, Fluquinconazole Ipconazole, Propiconazole, Metconazole, Tebuconazole, Triadimenol, Azoxystrobin, Fluoxastrobin, Kresoxim-methyl, Picoxystrobin, Pyraclostrobin, Boscalid, Chlorothalonil, Cyprodinil, Fludioxonil, Fluopyram, Thiophanat-methyl, Penflufen, Isopyrazam, Sedaxane, Myclobutonil, Prochloraz, Spiroxamine, N-(3′,4′-dichloro-5-fluoro[1,1′-biphenyl]-2-yl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide, Ametoctradin, 5-Chlor-6-(2,4,6-trifluorphenyl)-7-(4-methylpiperidin-1-yl)[1,2,4]triazolo[1,5-a]pyrimidin, 1-methyl-N-{2-[1′-methyl-1,1′-bi(cyclopropyl)-2-yl]phenyl}-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide, N-{2-[1,1′-bi(cyclopropyl)-2-yl]phenyl}-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxamide, 1-methyl-N-{2-[1′-methyl-1,1′-bi(cyclopropyl)-2-yl]phenyl}-3-(difluoromethyl)-1H-pyrazole-4-carboxamide, and N-{2-[1,1′-bi(cyclopropyl)-2-yl]phenyl}-1-methyl-3-(difluoromethyl)-1H-pyrazole-4-carboxamide.

4. The composition according to claim 1 wherein the at least one further insecticidally active compound (B-II) is selected from the group consisting of Acephate, Acequinocyl, Acrinathrin, Aldicarb, Amitraz, Anthraquinone, Azinphos-Methyl, Azocyclotin, Bendiocarb, Benfuracarb, Bifenthrin, Buprofezin, Carbaryl, Carbofuran, Carbosulfan, Cartap, Chlorfluazuron, Chlorpyrifos, Chlorpyrifos-M, Clofentezine, Clothianidin, Cyfluthrin, Cyhexatin, Cypermethrin, Cyromazine, Deltamethrin, Diazinon, Dichloropropene, Dichlorvos, Dimethoate, Disulfoton, Ethion, Ethiprole, Ethoprophos, Etofenprox, Fenamiphos, Fenitrothion, Fenobucarb, Fenpyroximate, Fenthion, Fipronil, Flubendiamide, Formetanate, Heptenophos, Hexythiazox, Imidacloprid, Metaldehyde, Methamidophos, Methiocarb, Methomyl, Methoxyfenozide, Milbemectin, M-Isothiocyanate, Permethrin, Phenthoate, Phosalone, Phoxim, Polyeder-Nuclear-Vir, Profenofos, Propargite, Prothiofos, Pyrethroids, Pyriproxifen, Quinalphos, Quinomethionate, Resmethrin, Silafluofen, Sodium-Tetrathiocarbonate, Spinosad, Spirodiclofen, Spiromesifen, Spirotetramat, Tebupirimphos, Tefluthrin, Thiacloprid, Thiamethoxam, Thiodicarb, Triazophos, Trichlorfon, and Triflumuron.

5. The composition according to claim 1 wherein the at least one compound having plant growth regulating activity (B-III) is selected from the group consisting of chlormequat, chlormequat-chloride, cyclanilide, dimethipin, ethephon, flumetralin, flurprimidol, inabenfide, mepiquat, mepiquat chloride, 1-methylcyclopropen, paclobutrazol, prohexadione-calcium, prohydrojasmon, tribufos, thidiazuron, trinexapac, trinexapac-ethyl and uniconazol.

6. The composition according to claim 1 wherein the weight ratio of (A) to (B-I), (B-II), or (B-III) is from 1:100 to 100:1.

7. (canceled)

8. (canceled)

9. The composition according to claim 1 further comprising adjuvants, solvents, carrier, surfactants or extenders.

10. A method for curatively or preventively controlling phytopathogenic fungi of plants or reducing mycotoxin contamination of plants or plant parts comprising applying the composition according to claim 1 to a seed, to a plant, to a fruit of the plant, to soil in which the plant is growing or to soil from which the plant is grown.

11. The method according to claim 10 comprising applying (A) and (B-I), (B-II) or (B-III) simultaneously or sequentially.

12. (canceled)

13. (canceled)

14. (canceled)

15. (canceled)

16. The method according to claim 10 wherein the composition is applied as a foliar treatment to the plant.

17. The method according to claim 16 wherein the composition is applied at a rate of from 0.1 to 10 kg/ha.

18. The method according to claim 10 wherein the composition is applied to the soil in which the plants are growing or to the soil from which the plants are grown.

19. The method according to claim 18 wherein the composition is applied at a rate of from 0.1 to 10 kg/ha.

20. The method according to claim 10 wherein the composition is applied to the seed.

21. The method according to claim 20 wherein the seed is seed of a transgenic plant.

22. The method according to claim 20 wherein the composition is applied to the seed at a rate of from 2 to 200 g/100 kg of seed.

23. The composition according to claim 1 further comprising seed.