With An Additional Active Ingredient (excludes Reaction Product Or Complex) Patents (Class 514/154)
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Publication number: 20130053333Abstract: This invention relates to novel aminoquinoline derivatives of Formula (I) or Ia, or pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering an aminoquinoline derivative, such as a derivative of primaquine.Type: ApplicationFiled: January 19, 2011Publication date: February 28, 2013Inventor: Roger D. Tung
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Publication number: 20130039869Abstract: Regimen for the treatment of rosacea include the application of an anti-redness composition to at least a portion of the cleansed area of skin afflicted with rosacea. The regimen may include the application of one or more of a polymetal complex, a composition containing metronidazole, and/or a protective composition. Kits containing components useful in performing such regimens are also described.Type: ApplicationFiled: February 8, 2012Publication date: February 14, 2013Applicant: JR CHEM, LLCInventors: Jose E. Ramirez, Hovig Ounanian
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Patent number: 8367644Abstract: The present invention provides a method for treating cancer in a mammal comprising contacting the cancer cells with a compound which is a apogossypol, derivative.Type: GrantFiled: October 7, 2010Date of Patent: February 5, 2013Assignee: The Burnham InstituteInventors: John C. Reed, Maurizio Pellecchia
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Publication number: 20130028850Abstract: A topical therapeutic hydrophobic breakable composition includes a carrier comprising (a) about 60% to about 99% by weight of at least one hydrophobic oil; (b) at least one viscosity-modifying agents selected from the group consisting of a fatty alcohol, a fatty acid and a wax; and (c) a tetracycline antibiotic, characterized in that at least part of the tetracycline antibiotic is suspended in the composition; the viscosity of the composition is at least about 30% higher than the viscosity of the carrier without the tetracycline antibiotic; and is higher than the viscosity of the hydrophobic oil and the tetracycline antibiotic without the viscosity modifying agents; and the amount of viscosity modifying agents can optionally be reduced by at least an amount by weight that would have increased the viscosity of the carrier without the tetracycline antibiotic by at least 30%; wherein the tetracycline is chemically stable in the composition for at least six months; wherein more than about 90% of the tetracyclineType: ApplicationFiled: October 1, 2010Publication date: January 31, 2013Applicant: FOAMIX LTD.Inventors: Dov Tamarkin, Elana Gazal, Irakliy Papiashvili, Yohan Hazot, David Schuz, Rita Keynan
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Publication number: 20130022661Abstract: A bio-remodable augmentation device including an implantable member configured for maintaining space in a bone defect. The implantable member is formed from a bio-remodable composite having structural properties so as to aid in the generation of new bone tissue and eventually be reabsorbed in the newly formed bone tissue. This structural and bio-remodable implant reduces, if not eliminates, the need to remove the implantable member from the patient once new bone tissue is formed. A kit including the implantable devices and bone growth material is disclosed. Methods of use are also disclosed.Type: ApplicationFiled: July 21, 2011Publication date: January 24, 2013Applicant: Warsaw Orthopedic, Inc.Inventor: William F. McKay
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Publication number: 20130023412Abstract: Fungicidal mixtures based on azolopyrimidinylamines.Type: ApplicationFiled: March 23, 2011Publication date: January 24, 2013Applicant: BASF SEInventors: Markus Gewehr, Jordi Tormo I Blasco, Egon Haden
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Publication number: 20120328549Abstract: The present invention provides oil compositions and associated methods and reagents, particularly useful for the treatment of dermatologic conditions. In some embodiments, provided compositions are formulated for and achieve transdermal delivery, for example by topical administration.Type: ApplicationFiled: January 23, 2012Publication date: December 27, 2012Applicant: ANTERIOS, INC.Inventors: Jonathan EDELSON, Timothy KOTYLA, Klaus THEOBALD
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Publication number: 20120321579Abstract: The present invention provides surfactant compositions and associated methods and reagents, particularly useful for the treatment of dermatologic conditions. In some embodiments, provided compositions are formulated for and achieve transdermal delivery, for example by topical administration.Type: ApplicationFiled: January 23, 2012Publication date: December 20, 2012Applicant: ANTERIOS, INC.Inventors: Jonathan EDELSON, Timothy KOTYLA, Klaus THEOBALD
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Publication number: 20120301464Abstract: Methods, kits, and compositions for treating dry eye disorders and other related eye diseases are provided, wherein the methods, kits, and compositions utilize a JAK inhibitor.Type: ApplicationFiled: August 1, 2012Publication date: November 29, 2012Applicant: INCYTE CORPORATIONInventors: Paul A. Friedman, Jordan S. Fridman, Monica E. Luchi, William V. Williams
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Publication number: 20120302527Abstract: The present invention is directed to a compound represented by Structural Formula (A): or a pharmaceutically acceptable salt thereof. The variables for Structural Formula (A) are defined herein. Also described is a pharmaceutical composition comprising the compound of Structural Formula (A) and its therapeutic use.Type: ApplicationFiled: August 9, 2012Publication date: November 29, 2012Applicant: Tetraphase Pharmaceuticals, Inc.Inventors: Jingye Zhou, Xiao-Yi Xiao, Louis Plamondon, Diana Katharine Hunt, Roger B. Clark, Robert B. Zahler
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Publication number: 20120302526Abstract: Provided herein are methods for treating negative effects of traumatic brain injury (TBI), post traumatic stress disorder (PTSD), or acute stress disorder (ASD). These methods comprise administration of an effective amount of ibudilast to a subject suffering from TBI, PTSD, or ASD.Type: ApplicationFiled: November 14, 2011Publication date: November 29, 2012Inventors: Daniel Stephen Barth, Krista Marie Rodgers
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Publication number: 20120283225Abstract: The present invention provides a novel therapeutic combination comprising one or more anti-androgen agents and one or more antibiotic/anti-inflammatory agents or pharmaceutically acceptable salts or hydrates thereof, useful for the treatment of a dermatological disorder.Type: ApplicationFiled: April 11, 2011Publication date: November 8, 2012Applicant: M. Alphabet 1,. LLCInventors: Howard Fein, Mindy B. Berlin
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Patent number: 8298564Abstract: A system comprising an implantable medical device and a second polymeric layer configured to be disposed on or about the implantable medical device is described. The device includes a first polymeric layer into which a first therapeutic agent is incorporated. A second therapeutic agent is incorporated into the second polymeric layer. The device is sterilized by a first sterilization method. The second polymeric layer is sterilized by a second sterilization method. A method for making a sterile implantable medical system is also described. The method includes incorporating a first therapeutic agent in a first polymeric material and disposing the first polymeric material on or about an implantable medical device. The first polymeric material and the implantable medical device are sterilized by a first sterilization method.Type: GrantFiled: September 27, 2006Date of Patent: October 30, 2012Assignee: Medtronic, Inc.Inventors: Thomas C Bischoff, Jennifer E Raeder-Devens
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Publication number: 20120270844Abstract: Provided herein arc PAK inhibitors. Also provided herein are compositions and methods for treating an individual suffering from Alzheimer's disease.Type: ApplicationFiled: October 8, 2010Publication date: October 25, 2012Applicant: aFRAXis, Inc.Inventors: Jay Lichter, Benedikt Vollrath, David Campbell, Sergio G. Durón
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Publication number: 20120258937Abstract: Methods for inhibiting estrogen hormone-induced pulmonary metastasis of smooth muscle cells that are capable of pulmonary metastasis comprise antagonizing the estradiol receptor on the smooth muscle cells such that pulmonary metastasis of the cells is inhibited.Type: ApplicationFiled: April 9, 2012Publication date: October 11, 2012Applicant: Fox Chase Cancer CenterInventors: Elizabeth P. Henske, Jane Yu
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Publication number: 20120232040Abstract: A medication for Acinetobacter baumannii infection comprises tetracycline; and a ginger compound, selecting from a group of [6]-dehydrogingerdione, [10]-gingerol, [6]-shogaol and [6]-gingerol. Also, a method for improving tetracycline-resistance of A. baumannii, by providing the ginger compound described above combined with tetracycline to against A. baumannii infection.Type: ApplicationFiled: March 7, 2011Publication date: September 13, 2012Inventors: Yen-Hsu CHEN, Hui-Min Wang, Chung-Yi Chen, Hsi-An Chen, Wei-Ru Lin
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Publication number: 20120225062Abstract: The present invention provides compounds of Formula I: and related compounds as further described herein, and pharmaceutical compositions comprising these compounds. The invention further provides methods to use these compounds and compositions for treating disorders associated with undesired levels of Pim kinase activity, including cancers and autoimmune disorders.Type: ApplicationFiled: March 2, 2012Publication date: September 6, 2012Inventors: Matthew Burger, Gisele Nishiguchi, Timothy D. Machajewski, Alice Rico, Robert Lowell Simmons, Aaron R. Smith, Victoriano Tamez, JR., Huw Tanner, Lifeng Wan
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Publication number: 20120207826Abstract: There is disclosed herein a composition for treating extracellular parasitic infections, the composition comprising one or more of the following combinations: at least one quinolone or fluoroquinolone together with at least one tetracycline, iodoquinol, an azole or imidazole; or at least two agents selected from the group consisting of iodoquinol, thiazolidones, tetracycline, nitroimidazoles, cotrimoxazole and diloxanide furoate.Type: ApplicationFiled: October 22, 2010Publication date: August 16, 2012Inventors: Thomas Julius Borody, Soledad Carsula
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Publication number: 20120195984Abstract: Described herein are compounds (including medical foods, pharmaceutical compositions, methods of compounding them), methods and systems for the diagnosis and/or treatment of prodromal schizophrenia. For example, described herein are methods of treating a developmentally-based neuropsychiatric disorder (schizophrenia) that includes first determining if a subject is at risk for such a disorder by examining phenotypical, serological immune markers and genotypical biomarkers. The biomarkers may be used to tailor the dose to be delivered by the medial food or pharmaceutical composition. Also described are compounds for treating prodromal (rather than full-blown) schizophrenia.Type: ApplicationFiled: February 2, 2012Publication date: August 2, 2012Inventor: Jay L. Lombard
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Publication number: 20120189710Abstract: Compositions and their use for treating bacterial infections are described, in particular compositions for treating multi-species infections and the treatment of bacterial infections arising from biofilms. The present invention also relates to antibacterial compositions for treating dental diseases. Compositions of the present invention may include a garlic extract or S-allyl cysteine, and optionally an antibiotic and/or an antiseptic.Type: ApplicationFiled: July 28, 2010Publication date: July 26, 2012Inventor: Raymond S. Steggles
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Publication number: 20120181201Abstract: A topical formulation comprising a tetracycline comprises two separate parts: (i) a first part comprising a tetracyline in solid form suspended in a first vehicle; and (ii) a second part comprising a second vehicle in which the tetracycline is soluble. Preferably the tetracycline is crystalline minocycline base. Suitably, a neutral vehicle is used for the first part of the formulation. The two parts of the formulation may be packaged in separate containers and are preferably topically applied therefrom simultaneously.Type: ApplicationFiled: June 25, 2010Publication date: July 19, 2012Applicant: HOVIONE INTER LIMITEDInventor: William Heggie
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Publication number: 20120172292Abstract: This invention discloses a method for enhancing the efficacy of antimicrobial, anti-protozoa and anti-cancer treatments by co-administering an inhibitor of endogenous NO production and/or NO scavenger.Type: ApplicationFiled: September 10, 2010Publication date: July 5, 2012Applicant: NEW YORK UNIVERSITYInventors: Evgeny A. Nudler, Ivan Gusarov
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Patent number: 8211875Abstract: A method for treating a neurofibroma, e.g. dermal neurofibroma, a subdermal neurofibroma, or a superficial plexiform neurofibroma, in a subject in need of such treatment is disclosed. The method comprises locally applying a composition to a neurofibroma either topically or intralesionally. This method does not encompass systemic administration of the composition to the subject to have an effect on the neurofibromas. Compositions useful for such treatments and methods of preparing the compositions are disclosed.Type: GrantFiled: February 2, 2006Date of Patent: July 3, 2012Assignee: Nexgenix Pharmaceuticals IncInventors: Ruihong Chen, Allan E. Rubenstein, Xiaodong Shen, Scott Stewart, Jin-Chen Yu
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Publication number: 20120165276Abstract: Disclosed are compounds having at least one quaternary alkyl ammonium functionality. The compounds inhibit bacterial efflux pump inhibitors and are used in combination with an anti-bacterial agent to treat or prevent bacterial infections. These combinations can be effective against bacterial infections that have developed resistance to anti-bacterial agents through an efflux pump mechanism.Type: ApplicationFiled: May 6, 2008Publication date: June 28, 2012Applicant: Mpex Pharmaceuticals, Inc.Inventors: TOMASZ GLINKA, Olga Lomovskaya, Keith Bostian, David M. Wallace
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Publication number: 20120165795Abstract: A therapeutic agent reservoir comprises a reservoir body comprising a polymer and a therapeutic agent mixed within the polymer, and an outer coating enclosing the reservoir body, wherein at least a portion of the outer coating comprises a rate-controlling membrane configured to provide a predetermined release rate of the therapeutic agent through the rate-controlling membrane.Type: ApplicationFiled: December 28, 2010Publication date: June 28, 2012Applicant: MEDTRONIC, INC.Inventors: Peter M. Seiler, Kenneth E. Cobian, Genevieve L. Gallagher, Zhongping C. Yang
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Publication number: 20120141467Abstract: Provided herein is a method for treating a tracheo-bronchial-alveolar tract disease in a subject in need thereof, the method comprising the step of administering to a subject in need of such treatment a pharmaceutical composition comprising a therapeutically effective amount of ascorbate or a derivative thereof. Also provided is a method for treating non-Hodgkin's lymphoma in a subject in need thereof, the method comprising the step of administering to the subject in need of such treatment a pharmaceutical composition comprising a therapeutically effective amount of ascorbate or a derivative thereof.Type: ApplicationFiled: December 3, 2010Publication date: June 7, 2012Inventor: Daniel J. Schneider
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Publication number: 20120141491Abstract: The subject application provides small compounds that are able to increase/enhance autophagy in various cells. These compounds are useful in augmenting existing treatments of various cancers, microbial/viral infections, and neurodegenerative diseases. Thus, the subject application also provides methods of treating various types of cancers, microbial/viral infections, and neurodegenerative diseases.Type: ApplicationFiled: August 9, 2010Publication date: June 7, 2012Applicant: University of Florida Research Foundation Inc.Inventors: William A. Dunn, Debra Everton Akin, Brian Keith Law
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Publication number: 20120135091Abstract: The present invention concerns the use of active compounds, including chalcogenides and sirtuin-modulating compounds, either alone or in combination for increasing or enhancing survivability and/or longevity in biological matter. In general aspects, the chalcogenides and other active compounds may modulate one or more sirtuin proteins. It includes compositions, methods, articles of manufacture and apparatuses for enhancing survivability in any of these biological materials, so as to preserve and/or protect them. In specific embodiments, there are also therapeutic methods and apparatuses for aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, organ transplantation, hyperthermia, wound healing, hemorrhagic shock, cardioplegia for bypass surgery, neurodegeneration, hypothermia, and cancer using the active compounds described.Type: ApplicationFiled: January 18, 2008Publication date: May 31, 2012Inventors: Mark B. Roth, Dana L. Miller
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Publication number: 20120129816Abstract: The present invention relates to novel aryl sulfonamide amine compounds of the formula (I), their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates described herein and pharmaceutically acceptable compositions containing them.Type: ApplicationFiled: March 3, 2009Publication date: May 24, 2012Applicant: Suven Life Sciences LimitedInventors: Ramakrishna Nirogi, Anil Karbhari Shinde, Rama Sastri Kambhampati, Pradeep Jayarajan, Gopinadh Bhyrapuneni, Venkateswarlu Jasti
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Publication number: 20120121724Abstract: The present invention is related to the composition and methods of manufacture of orally-dissolvable, edible films as a vehicle for the non-invasive administration of nitroglycerin, as well as other therapeutic agents either with or without nitroglycerin, through the mucosal tissues of the oral cavity. The films include a water soluble film-forming polymer such as pullulan. Methods for producing the films are also disclosed.Type: ApplicationFiled: January 20, 2012Publication date: May 17, 2012Inventor: Todd Maibach
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Publication number: 20120114605Abstract: Methods of treating a subject having, or at risk of having, a myeloproliferative disorder are provided according to embodiments of the present invention which include administering a therapeutically effective amount of an arachidonate 5-lipoxygenase (5-LO) inhibitor to the subject. Combinations of therapeutic agents are administered according to embodiments of the present invention. In some embodiments, two or more 5-LO inhibitors are administered to a subject to treat a myeloproliferative disorder. In further embodiments, at least one 5-LO inhibitor and at least one additional therapeutic agent are administered to a subject to treat a myeloproliferative disorder. Methods of inhibiting leukemia stem cells are provided according to embodiments of the present invention which include contacting leukemia stem cells with an effective amount of an arachidonate 5-lipoxygenase inhibitor.Type: ApplicationFiled: April 26, 2010Publication date: May 10, 2012Inventor: Shaoguang Li
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Publication number: 20120115820Abstract: The present invention relates to a use of a compound having an acid pump antagonistic activity, a pharmaceutically acceptable salt thereof or a pharmaceutical composition thereof for the manufacture of a medicament for prevention or treatment of diseases in which abnormal gastrointestinal motility is involved. In addition, the present invention relates to the method of prevention or treatment including administering to a human or animal. The compound, the pharmaceutically acceptable salt thereof, or pharmaceutical compositions containing them, may be used in combination with one or more second active agent. Further, the present invention relates to pharmaceutical compositions and kits comprising a compound having an acid pump antagonistic activity or a pharmaceutically acceptable salt thereof for the prevention or treatment of said diseases.Type: ApplicationFiled: July 9, 2010Publication date: May 10, 2012Inventors: Nobuyuki Takahashi, Shinichi Koizumi
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Publication number: 20120101053Abstract: The present invention relates to compounds capable of inhibiting and/or decreasing the activity of one or more cathepsins, thereby treating and/or preventing various disease states associated with one or more cysteine proteases including, but not limited to, cathepsins and papain-like cysteine proteases. Disease states treated and/or prevented by the compounds of the invention include, but are not limited to, mammalian parasitic diseases in which the parasite utilizes a critical cysteine protease from the papain family. Examples of parasitic diseases to be treated or prevented by the compounds of the invention include, but are not limited to, toxoplasmosis, malaria, African trypanosomiasis, Chagas disease, leishmaniasis, coccidiosis, giardiosis, cryptosporidiosis or schistosomiasis.Type: ApplicationFiled: June 16, 2010Publication date: April 26, 2012Inventors: Cameron Black, Christian Beaulieu
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Publication number: 20120101071Abstract: This invention provides a method for treating or preventing malaria in a subject. The method includes administering to the subject an effective amount of a substituted tetracycline compound, such that malaria is treated or prevented. In one aspect, the invention relates to pharmaceutical compositions which include an effective amount of a tetracycline compound to treat malaria in a subject and a pharmaceutically acceptable carrier. The substituted tetracycline compounds of the invention can be used to in combination with one or more anti-malarial compounds or can be used to treat or prevent malaria which is resistant to one or more other anti-malarial compounds.Type: ApplicationFiled: December 28, 2011Publication date: April 26, 2012Applicant: Paratek Pharmaceuticals, Inc.Inventors: Michael DRAPER, Mark L. NELSON
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Publication number: 20120088671Abstract: The present invention provides polyphenolic compositions derived from a plant that inhibit the formation of a biofilm. Also provided are combinations that comprise at least one phenolic phytochemical and at least one antimicrobial agent that inhibit the growth of an established biofilm. Further, the present invention provides methods for inhibiting the formation and growth of biofilms.Type: ApplicationFiled: October 6, 2011Publication date: April 12, 2012Applicant: BOARD OF TRUSTEES UNIVERSITY OF ARKANSASInventors: Cassandra L. Quave, Mark S. Smeltzer, Cesar M. Compadre, Howard Hendrickson
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Publication number: 20120076766Abstract: A method of selecting the constituent elements of a therapeutic composition for application to wounds having a pathogen load is disclosed.Type: ApplicationFiled: April 21, 2011Publication date: March 29, 2012Inventors: D. Howard Phillips, Steven Keough
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Publication number: 20120053155Abstract: A system and method for reverting the antibiotic tolerance of persister cells. Brominated furanones, which are quorum sensing inhibitors, are used to revert the antibiotic tolerance of persister cells and enhance their susceptibility to antibiotics by up to one hundred fold. Brominated furanones can be used against bacterial persister cells in biofilms or planktonic form.Type: ApplicationFiled: August 9, 2011Publication date: March 1, 2012Applicant: Syracuse UniversityInventors: Dacheng Ren, Jiachuan Pan
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Publication number: 20120022001Abstract: A method of parenterally administering a composition, the method including parenterally administering to a person a composition including at least one omega-3 fatty acid and at least one drug, wherein the at least one omega-3 fatty acid source and the at least one drug are administered simultaneously.Type: ApplicationFiled: September 12, 2011Publication date: January 26, 2012Applicant: STABLE SOLUTIONS LLCInventor: David F. Driscoll
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Publication number: 20120009639Abstract: The control of the microbial contamination during the sugar fermentation in the processes for obtaining alcohol is a very important action to increase the productivity of the alcoholic fermentation processes. The Saccharomyces cerevisiae yeast cells engage a very tough nutritional competition for the sugarcane juice with the bacteria (Lactobacillus sp and Acetobacter) and the wild yeasts. The proposed composition uses an antimicrobial agent of the guanidine family, such as for example, poly(hexamethyl biguanide), an antibiotic agent, and also a surfactant agent, to prevent the undesired microbial growth. The present invention further refers to the process for controlling the microbial contamination through the use of said agents.Type: ApplicationFiled: February 11, 2010Publication date: January 12, 2012Inventors: Mauricio Da Silva Franzin, Maria Regina Prioli
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Publication number: 20120010127Abstract: In part, the present invention is directed to compositions comprising a FabI inhibitor and at least one other bioactive agent. In another part, the present invention is directed to antibacterial compositions comprising a compound of formulas I-III and at least one other antibacterial agent.Type: ApplicationFiled: December 8, 2010Publication date: January 12, 2012Inventors: JUDD M. BERMAN, MOLLY B. SCHMID, JOHN D. MENDLEIN, NACHUM KAPLAN
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Publication number: 20110307967Abstract: Mice comprising a human p16 transgene operably linked to an inducible promoter and capable of controlled expression of p16 are provided. Also provided are cells, tissues, and organs obtainable from such mice, and methods for producing p16 transgenic mice.Type: ApplicationFiled: June 10, 2011Publication date: December 15, 2011Applicant: Fox Chase Cancer CenterInventor: Greg H. Enders
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Publication number: 20110301127Abstract: The instant methods and compositions represent an advance in controlling drug resistance in microbes. AcrAB-like efflux pumps have been found to control resistance to drugs, even in highly resistant microbes. Accordingly, methods of treating infection, methods of screening for inhibitors of AcrAB-like efflux pumps, and methods of enhancing antimicrobial activity of drugs are provided. Pharmaceutical composition comprising an inhibitor of an AcrAB-like efflux pump and an antimicrobial agent are also provided.Type: ApplicationFiled: August 16, 2011Publication date: December 8, 2011Applicant: TRUSTEES OF TUFTS COLLEGEInventors: Margret OETHINGER, Stuart B. LEVY
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Publication number: 20110294760Abstract: The invention generally relates to compositions and methods for preventing sternal wound infections, such as mediastinitis. In certain embodiments, the invention provides an antimicrobial composition including at least one bioresorbable polymer, such as a tyrosine-derived polyesteramide, and at least one antimicrobial agent, in which the composition is adapted to be topically applied to an esophageal perforation in a subject or a median sternotomy incision site in the subject, and in which the at least one antimicrobial agent is present in an amount effective to inhibit development of mediastinitis in the subject.Type: ApplicationFiled: June 1, 2010Publication date: December 1, 2011Applicant: TyRx Pharma, Inc.Inventors: Raman Bahulekar, Arikha Moses, Satish Pulapura, William C. McJames, II, Fatima Buevich
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Patent number: 8067397Abstract: The present invention relates to administering a doxycycline compound into a diseased intervertebral disc.Type: GrantFiled: May 14, 2009Date of Patent: November 29, 2011Assignee: DePuy Spine, Inc.Inventors: Mohamed Attawia, Thomas M. DiMauro, Hassan Serhan, Sudhakar Kadiyala, David Urbahns, Gregory Collins, Laura J. Brown, Jeffrey C. Geesin
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Publication number: 20110288056Abstract: Disclosed are once-daily formulations containing tetracyclines, especially doxycycline. Such formulations are useful, for instance, for the treatment of collagenase destructive enzyme-dependent diseases, such as periodontal disease and acne, and acute and chronic inflammatory disease states, such as rosacea and arthritis.Type: ApplicationFiled: December 17, 2010Publication date: November 24, 2011Inventors: Rong-Kun Chang, Arash Raoufinia, Niraj Shah
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Publication number: 20110280921Abstract: The present invention relates to hydrogels endowed with antibacterial properties, to be used for injection in damaged bones or in the production of antibacterial coatings of prostheses for implant in the human or animal body, obtained by loading with antibacterial agents hydrogels formed by derivatives of hyaluronic acid; the invention also relates to a kit of parts for producing the antibacterial hydrogels.Type: ApplicationFiled: January 29, 2010Publication date: November 17, 2011Applicants: NOVAGENIT S.R.L., MERO S.R.LInventors: Gaetano Giammona, Giovanna Pitarresi, Fabio Palumbo, Carlo Luca Romano, Enzo Meani, Edgardo Cremascoli
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Publication number: 20110274651Abstract: Compositions and methods for treating or preventing infectious diseases, and inhibiting the ability of microbes to travel within mammalian cells, and inhibiting microbial replication, are disclosed. The compositions include various noscapine analogs, which are capable of blocking the movement of viruses and other microbes within mammalian and other cells by inhibiting the cytoplasmic transport mechanisms within the cells. The compositions described herein include an effective amount of the noscapine analogues described herein, along with a pharmaceutically acceptable carrier or excipient. The compositions can also include one or more additional antimicrobial compounds.Type: ApplicationFiled: September 4, 2009Publication date: November 10, 2011Applicant: Emory UniversityInventors: Cory Acuff, Daniel Kalman
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Publication number: 20110269720Abstract: Methods and kits for treating infection associated with implantation of a medical device use of minocycline and rifampin microparticles. The microparticles, in a suitable medium, can be injected in a patient in proximity to the device. The drugs may be configured to be released from the polymer matrix in a controlled manner by manipulation of the properties of the polymer forming the microparticle. By injecting the drugs in the form of microparticles, the drugs can be distributed in a manner so that the entire pocket is protected without affecting device function. The microparticles can be produced aseptically without affecting the manufacturing of the device.Type: ApplicationFiled: April 28, 2010Publication date: November 3, 2011Applicant: MEDTRONIC, INC.Inventors: Christopher M. Hobot, Randall V. Sparer, Mark E. Hughes, William Ferris
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Publication number: 20110245148Abstract: The present invention relates to a composition comprising: a) 0.01-20% wt/wt acetic acid and b) a physiologically tolerable buffer capable of maintaining acetic acid at a pH in the range of 2-7; and use of such a composition as an antimicrobial agent.Type: ApplicationFiled: June 23, 2009Publication date: October 6, 2011Applicants: DANMARKS TEKNISKE UNIVERSITET, BISPEBJERG HOSPITAL, RIGSHOSPITALET COPENHAGEN UNIVERTISY HOSPITALInventors: Michael Christian Givskov, Thomas Bjarnsholt, Preben Homoe, Niels Hoiby, Peter Østrup Jensen, Helle Krogh Johansen, Klaus Kirketerp-Moller
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Publication number: 20110229465Abstract: The present invention provides pharmaceutical compositions and kits comprising an agent capable of activating CD4+CD25+ regulatory T cells and methotrexate, and methods of treatment and medical uses utilising the same.Type: ApplicationFiled: March 29, 2011Publication date: September 22, 2011Inventors: Frank Osterroth, Silke Aigner, Christoph Uherek, Andrea Wartenberg-Demand, Anatoly Rudnev, Michael Soldan, Christoph Bruecher, Benjamin Daelken, Chantal Zuber, Gregor Schulz, Niklas Czeloth