Ortho-hydroxybenzoic Acid (i.e., Salicyclic Acid) Or Derivative Doai Patents (Class 514/159)
  • Patent number: 10667937
    Abstract: The magnetorheological (MAR) medical brace includes a flexible outer shell that fits around the anatomical area to be braced and a plurality of adjustable straps for securing the shell onto the anatomical area. The shell encases a MAR pack filled with magnetorheological fluid or gel. A plurality of magnets is attached to or encased in the shell to provide magnetic field acting on the MAR pack. The interaction of the magnetic field with the MAR pack adjustably increases or decreases the stiffness of the shell depending on the strength of the magnetic field. A control mechanism is provided for selective adjustment of the magnetic field and other functions.
    Type: Grant
    Filed: July 10, 2017
    Date of Patent: June 2, 2020
    Inventors: Clifford T. Solomon, Theodore C. Solomon
  • Patent number: 10653778
    Abstract: The present specification discloses pharmaceutical compositions, methods of preparing such pharmaceutical compositions, and methods and uses of treating a chronic inflammation and/or an inflammatory disease in an individual using such pharmaceutical compositions.
    Type: Grant
    Filed: November 30, 2018
    Date of Patent: May 19, 2020
    Assignee: Infirst Healthcare Limited
    Inventors: Robin M. Bannister, John Brew, Wilson Caparros-Wanderely, Suzanne J. Dilly, Olga Pleguezeulos Mateo, Gregory A. Stoloff
  • Patent number: 10570161
    Abstract: A new family of therapeutics which provides a controlled-release delivery platform for non-steroidal anti-inflammatory agents on an ester or an ester-carbonate backbone is disclosed herein. These agents are reversible inhibitors of acetylcholinesterase and are thus useful for clinical conditions benefiting from inflammation suppression and cholinergic intervention. These compounds are of the general formula wherein n=0, 1; X=C, Si, and N+ and NSAID=ibuprofen, naproxen, indomethacin and diclofenac. Other embodiments are also disclosed.
    Type: Grant
    Filed: November 30, 2016
    Date of Patent: February 25, 2020
    Assignees: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY, LEHIGH UNIVERSITY
    Inventors: Jeffrey D. Laskin, Diane E. Heck, Mou-Tuan Huang, Karine Fabio, Carl J. Lacey, Sherri C. Young, Pramod Mohanta, Christophe Guillon, Ned D. Heindel
  • Patent number: 10505993
    Abstract: An apparatus and method is provided for healing and regeneration of live human and animal bodies and influencing interaction and intercommunication at the cellular level. The apparatus can include one or more environmental and/or body sensors. An electrical circuit can also be provided to produce a square or trapezoidal wave that is delivered to a transducer for application, preferably timed at specific frequencies Delta, Theta, Alpha, to Beta, based on information received from the one or more sensors. In certain embodiments, a DC power source can be provided which allows the apparatus to be portable. A wireless communication module can also be provided.
    Type: Grant
    Filed: August 7, 2017
    Date of Patent: December 10, 2019
    Assignee: BLUGREEN TECHNOLOGIES, INC.
    Inventors: Iulius Dutu, Razvan Dutu
  • Patent number: 10493019
    Abstract: A new natural oil personal care composition and system for treating damaged hair and/or supporting healthy hair and healthy hair growth. The composition comprises a blend of natural oils including Jamaican black castor oil, and one or more of natural sweet almond oil (preferably unrefined), pure avocado oil, and hemp seed oil (preferably unrefined). The oils are preferably organic. The composition is useful for repairing damaged, depleted and/or thinning hair due to various factors, including inadequate nutrition or overproduction of sebum, which can result in hair loss. The composition is also useful for repairing dry, frizzy, oily, dull (low shine), and brittle hair that has been naturally damaged by the elements (e.g. the sun, heat, wind, and/or cold), by wearing head gear or hair accessories that create friction with the hair surface (e.g. helmets, hair elastics and hair bands), by inappropriate or overuse use of hair styling tools (e.g.
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: December 3, 2019
    Assignee: May 11, LLC
    Inventor: Romina Manenti
  • Patent number: 10450260
    Abstract: This disclosure relates to compounds containing both an NO-releasing moiety and an H2S-releasing moiety and the use of such compounds in treating inflammatory diseases, including cancers.
    Type: Grant
    Filed: May 25, 2017
    Date of Patent: October 22, 2019
    Assignee: Research Foundation of The City University of New York
    Inventors: Khosrow Kashfi, Ravinder Kodela
  • Patent number: 10426748
    Abstract: The present specification discloses pharmaceutical compositions, methods of preparing such pharmaceutical compositions, and methods and uses of treating a chronic inflammation and/or an inflammatory disease in an individual using such pharmaceutical compositions.
    Type: Grant
    Filed: June 19, 2018
    Date of Patent: October 1, 2019
    Assignee: Infirst Healthcare Limited
    Inventors: Robin Mark Bannister, John Brew, Wilson Caparros-Wanderley, Gregory Alan Stoloff, Suzanne Jane Dilly, Gemma Szucs, Olga Pleguezuelos Mateo
  • Patent number: 10426969
    Abstract: A magnetic coil system featuring a multi-layer structure, a spherical shape, or both allows for efficient generation of a gradient magnetic field that induces an electric field in air in a region proximate to the coil. By subjecting at least a portion of a person's brain to the induced electric field various psychiatric disorders can be treated.
    Type: Grant
    Filed: August 16, 2017
    Date of Patent: October 1, 2019
    Assignee: The McLean Hospital Corporation
    Inventor: Michael Rohan
  • Patent number: 10413583
    Abstract: Synthetic probes for detecting the activity of enzymes that catalyze reactions of post-translationally modified cysteine residues are described. The probes include “turn-on” probes that include a carbamate linkage that is cleaved via an intramolecular reaction with a free thiol produced by an enzyme catalyzed activity. The probes also include ratiometric, Michael addition-based probes that respond to enzymatic activity by a change in structure that results in a change in fluorescence properties. Methods of using the probes to detect enzymatic activity and disease are described. For example, the probes can be used to detect enzymatic activity in a variety of samples, including live cells and heterogeneous tissues. In addition, prodrugs that can be activated by enzymes that catalyze reactions of post-translationally modified cysteine residues and methods of using the prodrugs to treat disease are described.
    Type: Grant
    Filed: November 30, 2017
    Date of Patent: September 17, 2019
    Assignee: The University of Chicago
    Inventors: Bryan C. Dickinson, Rahul S. Kathayat, Michael W. Beck
  • Patent number: 10300294
    Abstract: It is an aspect of the present invention to provide a method for recording a response to Transcranial Magnetic Stimulation (TMS) utilizing a bi-phasic double pulse pair from a TMS coil device to stimulate a subject wherein the second pulse has a lower amplitude compared to the first pulse in the bi-phasic double pulse pair. Significant advantages are achieved using bi-phasic double pulse pairs, particularly where the second pulse in a pair has an intensity lower than the first. Obtaining measurements is simpler and more accurate as the number and intensity of stimulation can be reduced compared to standard single pulse stimulation.
    Type: Grant
    Filed: September 7, 2012
    Date of Patent: May 28, 2019
    Assignee: Nexstim Oyj
    Inventors: Tuomas Neuvonen, Henri Hannula, Gustaf Jarnefelt, Jarmo Laine
  • Patent number: 10279191
    Abstract: A system for treating neurological conditions by low-frequency time varying electrical stimulation includes an electrical device for applying such low-frequency energy, in a range below approximately 10 Hz, to the patient's brain tissue. An implantable embodiment applies direct electrical stimulation to electrodes implanted in or on the patient's brain, while a non-invasive embodiment causes a magnetic field to induce electrical currents in the patient's brain.
    Type: Grant
    Filed: June 2, 2017
    Date of Patent: May 7, 2019
    Assignee: NeuroPace, Inc.
    Inventors: David R. Fischell, Adrian R. M. Upton
  • Patent number: 10231995
    Abstract: The use of selenite- or selenate-containing preparations supplemented with pharmaceutically acceptable or food-compatible acids for the preparation of an agent intended for topical or buccal application or mucosal administration is described.
    Type: Grant
    Filed: October 5, 2017
    Date of Patent: March 19, 2019
    Assignee: SELO MEDICAL GMBH
    Inventors: Bodo Kuklinski, Peter Kössler, Norbert Fuchs
  • Patent number: 10231943
    Abstract: The present specification discloses pharmaceutical compositions, methods of preparing such pharmaceutical compositions, and methods and uses of treating a cardiovascular disease in an individual using such pharmaceutical compositions.
    Type: Grant
    Filed: September 12, 2017
    Date of Patent: March 19, 2019
    Assignee: Infirst Healthcare Limited
    Inventors: Robin Mark Bannister, John Brew, Suzanne Jane Dilly, Gregory Alan Stoloff, Wilson Caparros Wanderley
  • Patent number: 10213381
    Abstract: The present specification discloses pharmaceutical compositions, methods of preparing such pharmaceutical compositions, and methods and uses of treating a chronic inflammation and/or an inflammatory disease in an individual using such pharmaceutical compositions.
    Type: Grant
    Filed: August 23, 2017
    Date of Patent: February 26, 2019
    Assignee: infirst Healthcare Limited
    Inventors: Robin M. Bannister, John Brew, Richard R. Reiley, III, Wilson Caparros Wanderley
  • Patent number: 10172847
    Abstract: A method for reducing, inhibiting, and eliminating inflammation and pain by using an effective amount of iron chelator composition to balance oxidative activity at a cutaneous site of inflammation and pain. The composition contained in transdermal formulations and administered topically in accordance with the invention can be combined with one or more suitable carriers and can be administered in conjunction with one or more additional therapeutic agents.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: January 8, 2019
    Inventor: Kenneth Russell
  • Patent number: 10155042
    Abstract: The present specification discloses pharmaceutical compositions, methods of preparing such pharmaceutical compositions, and methods and uses of treating a chronic inflammation and/or an inflammatory disease in an individual using such pharmaceutical compositions.
    Type: Grant
    Filed: June 5, 2017
    Date of Patent: December 18, 2018
    Assignee: Infirst Healthcare Limited
    Inventors: Robin M. Bannister, John Brew, Wilson Caparros-Wanderely, Suzanne J. Dilly, Olga Pleguezeulos Mateo, Gregory A. Stoloff
  • Patent number: 10004704
    Abstract: The present specification discloses pharmaceutical compositions, methods of preparing such pharmaceutical compositions, and methods and uses of treating a chronic inflammation and/or an inflammatory disease in an individual using such pharmaceutical compositions.
    Type: Grant
    Filed: May 31, 2016
    Date of Patent: June 26, 2018
    Assignee: Infirst Healthcare Limited
    Inventors: Robin Mark Bannister, John Brew, Wilson Caparros-Wanderley, Gregory Alan Stoloff, Suzanne Jane Dilly, Gemma Szucs, Olga Pleguezuelos Mateo
  • Patent number: 9987215
    Abstract: The present invention relates to process for preparing cosmetic compositions at two stages. The first relates to the preparation of organogels in which liquid oils are structured by a mixture of structuring agents such as monoglycerides and waxes, which also have the addition of other components such as polymers and polyol esters. The second step is the formation of the cold or hot process cosmetic compositions where emulsions are prepared by the addition of water, aqueous solutions and other components, to the organogel. The emulsions prepared have superior sensory, chemical-physical and stability characteristics, to those currently produced by the classic technology of preparation with emulsifiers.
    Type: Grant
    Filed: March 22, 2013
    Date of Patent: June 5, 2018
    Assignee: CHEMYUNION QUIMICA LTDA.
    Inventors: Cecilia Nogueira, Cristiane Rodrigues da Silva Pacheco, Daniel Barrera Arellano, Daniele Cristina Zulim Botega, Mario Luiz Mathias Netto
  • Patent number: 9901638
    Abstract: A combination of antibiotics including rifabutin, clarithromycin and clofazimine for the treatment of an autoimmune disease such as multiple sclerosis and related diseases. In a further aspect, there is provided a composition comprising a combination of two or more antibiotic agents for the treatment of an autoimmune disease, said two or more antibiotic agents selected from rifabutin, clofazimine, and at least one macrolide.
    Type: Grant
    Filed: September 19, 2012
    Date of Patent: February 27, 2018
    Assignee: RedHill Biopharma Ltd.
    Inventors: Reza Fathi, Patrick Laughlin McLean, Harry Jefferson Leighton
  • Patent number: 9827215
    Abstract: The present specification discloses pharmaceutical compositions, methods of preparing such pharmaceutical compositions, and methods and uses of treating a chronic inflammation and/or an inflammatory disease in an individual using such pharmaceutical compositions.
    Type: Grant
    Filed: June 28, 2016
    Date of Patent: November 28, 2017
    Assignee: Infirst Healthcare Limited
    Inventors: Robin M. Bannister, John Brew, Richard R. Reiley, III, Wilson Caparros Wanderley
  • Patent number: 9820952
    Abstract: The present specification discloses pharmaceutical compositions, methods of preparing such pharmaceutical compositions, and methods and uses of treating a chronic inflammation and/or an inflammatory disease in an individual using such pharmaceutical compositions.
    Type: Grant
    Filed: June 28, 2016
    Date of Patent: November 21, 2017
    Assignee: Infirst Healthcare Limited
    Inventors: Robin M. Bannister, John Brew, Richard R. Reiley, III, Wilson Caparros Wanderley
  • Patent number: 9789075
    Abstract: The present specification discloses pharmaceutical compositions, methods of preparing such pharmaceutical compositions, and methods and uses of treating a cardiovascular disease in an individual using such pharmaceutical compositions.
    Type: Grant
    Filed: July 25, 2016
    Date of Patent: October 17, 2017
    Assignee: Infirst Helathcare Limited
    Inventors: Robin Mark Bannister, John Brew, Suzanne Jane Dilly, Gregory Alan Stoloff, Wilson Caparros-Wanderley
  • Patent number: 9750810
    Abstract: The present specification discloses pharmaceutical compositions, methods of preparing such pharmaceutical compositions, and methods and uses of treating a chronic inflammation and/or an inflammatory disease in an individual using such pharmaceutical compositions.
    Type: Grant
    Filed: February 12, 2016
    Date of Patent: September 5, 2017
    Assignee: Infirst Healthcare Limited
    Inventors: Robin M. Bannister, John Brew, Wilson Caparros-Wanderely, Suzanne J. Dilly, Olga Pleguezeulos Mateo, Gregory A. Stoloff
  • Patent number: 9744132
    Abstract: The present specification discloses pharmaceutical compositions, methods of preparing such pharmaceutical compositions, and methods and uses of treating a chronic inflammation and/or an inflammatory disease in an individual using such pharmaceutical compositions.
    Type: Grant
    Filed: August 7, 2015
    Date of Patent: August 29, 2017
    Assignee: Infirst Healthcare Limited
    Inventors: Robin M. Bannister, John Brew, Richard R. Reiley, III, Wilson Caparros Wanderley
  • Patent number: 9737698
    Abstract: A method and system for treating patients with Alzheimer disease includes steps and equipment operative for subjecting a patient suffering from Alzheimer disease to a non-invasive action directed toward a patient's brain and causing a cavitation process in the patient's brain liquid in the vicinity of lesions and thereby destroying the latter.
    Type: Grant
    Filed: January 4, 2016
    Date of Patent: August 22, 2017
    Inventors: Mikhail Topchiashvili, Luba Chigirinskay, Marika Cherfas
  • Patent number: 9717667
    Abstract: An oral care composition is provided wherein the composition comprises an ionic liquid, wherein the ionic liquid comprises: a) a quaternary ammonium cation of the formula wherein R1, R2, R3 and R4 are each an organic moiety and may be the same or different, and at least one of R1, R2, R3 and R4 includes a hydroxyl; and b) an anion selected from the group consisting of salicylate, alkylsulfate, sulfate, acetate, halide, phosphate, alkyl phosphate and tosylate; wherein the oral care composition is a mouth rinse, toothpaste, toothpowder, oral bead or strip, fluid-encased dental strip, irrigation fluid, plaque removal liquid, dental floss, hard candy, soft candy, lozenge, chewing gum, or lollipop.
    Type: Grant
    Filed: December 20, 2012
    Date of Patent: August 1, 2017
    Assignee: Colgate-Palmolive Company
    Inventors: Madhusudan Patel, Guillaume Picquet, Mark Vandeven, Mahmoud Hassan, Rosa Paredes
  • Patent number: 9693980
    Abstract: The present specification discloses pharmaceutical compositions, methods of preparing such pharmaceutical compositions, and methods and uses of treating a chronic inflammation and/or an inflammatory disease in an individual using such pharmaceutical compositions.
    Type: Grant
    Filed: May 31, 2016
    Date of Patent: July 4, 2017
    Assignee: Infirst Healthcare Limited
    Inventors: Robin Mark Bannister, John Brew, Wilson Caparros-Wanderley, Gregory Alan Stoloff, Suzanne Jane Dilly, Gemma Szucs, Olga Pleguezuelos Mateo
  • Patent number: 9670121
    Abstract: The present invention aims to provide a compound superior in broad utility and stability, which is useful as a protecting reagent (anchor) of amino acid and/or peptide in liquid phase synthesis and the like of a peptide having a C-terminal etc., which are of a carboxamide (—CONHR)-type, an organic synthesis reaction method (particularly peptide liquid phase synthesis method) using the compound, and a kit for peptide liquid phase synthesis containing the compound, and has found that the object can be achieved by a particular compound having a diphenylmethane skeleton.
    Type: Grant
    Filed: August 28, 2015
    Date of Patent: June 6, 2017
    Assignee: AJINOMOTO CO., INC.
    Inventor: Daisuke Takahashi
  • Patent number: 9649502
    Abstract: Described herein, in certain embodiments, are devices and methods for modulating the electrical activity of a brain in a targeted manner using a weak magnetic field, generally field with a strength of less than about 100 Gauss. The magnetic field is varied over time in a periodic manner, generally with a frequency tuned to specifically affect one of the intrinsic frequencies of the brain, optionally the alpha frequency. The “Low Field Magnetic Stimulation” devices and methods described herein modulate the electrical activity of a brain without requiring medication. Methods and devices described herein gently “tune” the brain and affect mood, focus, and cognition of human subjects.
    Type: Grant
    Filed: November 13, 2012
    Date of Patent: May 16, 2017
    Assignee: NEOSYNC, INC.
    Inventors: James William Phillips, Yi Jin
  • Patent number: 9604925
    Abstract: Disclosed are compositions and methods for treating bacterial infections.
    Type: Grant
    Filed: May 8, 2015
    Date of Patent: March 28, 2017
    Assignee: Purdue Research Foundation
    Inventors: Cynthia Stauffacher, Mark Alfred Lipton, Mohamed Naguieb Seleem, Tim Jonathan Schmidt, Calvin Nicklaus Steussy, Jr., Victor W Rodwell
  • Patent number: 9596379
    Abstract: Provided is an image reading apparatus capable of reading an image of an original at a high resolution by an image pickup unit by reducing an influence of a dark line included in a projection image on an original placing stand, which is ascribable to a displaying element included in a projecting unit and is to be exerted on an original placed on original placing stand. The image reading apparatus includes: an image pickup unit conducting image pickup for a placing surface; a projecting unit projecting an image on placing surface; and a switching unit switching a blur amount of image on placing surface, in which the switching unit sets a blur amount of image in a first mode, in which the image pickup is not conducted by image pickup unit, smaller than that in a second mode, in which the image pickup is conducted by image pickup unit.
    Type: Grant
    Filed: March 1, 2016
    Date of Patent: March 14, 2017
    Assignee: CANON KABUSHIKI KAISHA
    Inventor: Ikutaro Mitsutake
  • Patent number: 9381180
    Abstract: The present specification discloses pharmaceutical compositions, methods of preparing such pharmaceutical compositions, and methods and uses of treating a chronic inflammation and/or an inflammatory disease in an individual using such pharmaceutical compositions.
    Type: Grant
    Filed: October 21, 2014
    Date of Patent: July 5, 2016
    Assignee: Infirst Healthcare Limited
    Inventors: Robin Mark Bannister, John Brew, Wilson Caparros-Wanderley, Gregory Alan Stoloff, Suzanne Jane Dilly, Gemma Szucs, Olga Pleguezuelos Mateo
  • Patent number: 9358242
    Abstract: Calcium glycerophosphate is found to be effective in treating and preventing a disease, disorder and/or condition of the respiratory system. The disease, disorder and/or condition is related to an obstructive or a restrictive condition of the respiratory airway.
    Type: Grant
    Filed: March 1, 2010
    Date of Patent: June 7, 2016
    Assignee: Prelief Inc.
    Inventors: Alan E. Kligerman, Margaret T. Weis
  • Patent number: 9326958
    Abstract: The present specification discloses pharmaceutical compositions, methods of preparing such pharmaceutical compositions, and methods and uses of treating a chronic inflammation and/or an inflammatory disease in an individual using such pharmaceutical compositions.
    Type: Grant
    Filed: October 21, 2014
    Date of Patent: May 3, 2016
    Assignee: INFIRST HEALTHCARE LIMITED
    Inventors: Robin Mark Bannister, John Brew, Wilson Caparros-Wanderley, Gregory Alan Stoloff, Suzanne Jane Dilly, Gemma Szucs, Olga Pleguezuelos Mateo
  • Patent number: 9308213
    Abstract: The present specification discloses pharmaceutical compositions, methods of preparing such pharmaceutical compositions, and methods and uses of treating a chronic inflammation and/or an inflammatory disease in an individual using such pharmaceutical compositions.
    Type: Grant
    Filed: January 14, 2014
    Date of Patent: April 12, 2016
    Assignee: Infirst Healthcare Limited
    Inventors: Robin M. Bannister, John Brew, Richard R. Reiley, III, Wilson Caparros Wanderley
  • Patent number: 9301973
    Abstract: The invention provides methods, compositions, and dietary formulations useful for preventing or treating dermatitis, promoting healthy skin, and retarding skin aging. The methods comprise administering to an animal a therapeutically effective amount of a combination of at least two of one or more antioxidants; one or more anti-glycation agents; one or more body fat reducing agents; one or more insulin sensitivity enhancing agents; and one or more anti-inflammatory agents.
    Type: Grant
    Filed: October 21, 2011
    Date of Patent: April 5, 2016
    Assignee: Nestec S.A.
    Inventors: Yuanlong Pan, Steven Scott Hannah, Rondo Paul Middleton
  • Patent number: 9271950
    Abstract: The present specification discloses pharmaceutical compositions, methods of preparing such pharmaceutical compositions, and methods and uses of treating a chronic inflammation and/or an inflammatory disease in an individual using such pharmaceutical compositions.
    Type: Grant
    Filed: January 14, 2014
    Date of Patent: March 1, 2016
    Assignee: Infirst Healthcare Limited
    Inventors: Robin M. Bannister, John Brew, Wilson Caparros-Wanderely, Suzanne J. Dilly, Olga Pleguezeulos Mateo, Gregory A. Stoloff
  • Patent number: 9079023
    Abstract: A portable electronic device comprises illuminating unit (300) configured to illuminate extrapupillarily the skin covering a user's eye cavity with optical radiation, thus resulting in diffuse propagation of optical radiation energy to an optically sensitive tissue of the user's eye, and adapting unit (500, 510, 520, 530, 550, 560) for adapting the illuminating unit (300) to the user's head.
    Type: Grant
    Filed: April 18, 2008
    Date of Patent: July 14, 2015
    Assignee: VALKEE OY
    Inventors: Antti Aunio, Juuso Nissilä
  • Patent number: 9073832
    Abstract: Disclosed are compositions and methods for treating bacterial infections.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: July 7, 2015
    Assignee: Purdue Research Foundation
    Inventors: Cynthia Stauffacher, Mark Alfred Lipton, Mohamed Naguieb Saleem, Tim Jonathan Schmidt, Calvin Nicklaus Steussy, Jr., Victor W Rodwell
  • Publication number: 20150148320
    Abstract: Cosmetic compositions comprising salicylic acid derivatives and methods of using such compositions to impart anti-aging benefits to the skin are disclosed. The salicylic acid derivatives are believed to have modulatory activity against one or more biochemical pathways implicated in the appearance of human skin.
    Type: Application
    Filed: March 11, 2014
    Publication date: May 28, 2015
    Applicant: Avon Products, Inc.
    Inventors: Kai Xi, Sung Bin Shin, Hong Hu
  • Patent number: 9040078
    Abstract: The invention provides a method for treating a subject suffering from a disease of the central nervous system which is associated with an inflammatory response, including, inter alia, multiple sclerosis, Amyotrophic Lateral Sclerosis (ALS), meningitis, Alzheimer's disease, pain, HIV-associated dementia, stroke, traumatic brain injury, encephalomyelitis, chronic inflammatory demyelinating polyneuropathy, cerebral ischemia-induced injury or any combination thereof. This invention further provides for the use of a conjugate, or composition comprising the same, for treating the subject, wherein the conjugate comprises a lipid or phospholipid moiety bonded to a physiologically acceptable monomer, dimer, oligomer, or polymer.
    Type: Grant
    Filed: August 17, 2004
    Date of Patent: May 26, 2015
    Assignee: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM
    Inventor: Saul Yedgar
  • Publication number: 20150140136
    Abstract: Pesticidal compositions containing plant essential oils, such as rosemary oil, wintergreen oil, etc., and methods for using same are disclosed.
    Type: Application
    Filed: June 19, 2014
    Publication date: May 21, 2015
    Inventors: Steven M. BESSETTE, A. David LINDSAY
  • Publication number: 20150140133
    Abstract: A system is described for long-term controlled release delivery of a drug or a therapeutic agent. According to the invention, one or more drugs or therapeutic agents contained in microspheres are mixed with a temperature sensitive hydrogel which is then introduced directly to the desired situs of the drug or therapeutic agent. The temperature sensitive hydrogel may also contain a drug or a therapeutic agent, for example, a pain relieving drug, for a short-term controlled release. The temperature sensitive hydrogel is in liquid state at room temperature, but upon injection, shortly becomes gelatinous. This system is particularly suitable for treatment of diseases, disorders, or conditions, for example, tumors, discogenic back pain, or arthritis, warranting localized administration of a drug or a therapeutic agent. In addition, the specification provides a method for production of a drug- or therapeutic agent-containing microspheres.
    Type: Application
    Filed: December 4, 2014
    Publication date: May 21, 2015
    Inventor: Tae-Hong Lim
  • Publication number: 20150133406
    Abstract: Control or repellency of biting arthropods, particularly biting insects, is accomplished by bringing the biting arthropods into contact with combinations of compounds identical or related to those found on human/animal skin or in plants acting synergistically with one another, or in combination with conventional repellents like DEET®, para-menthane-3,8-diol (PMD), sec-butyl-2-(2-hydroxyethyl) piperidine carboxylate (“Picaridin”), or other nitrogen containing repellents selected from amines, amides and nitrogen containing heterocyclic compounds, or any synergistic combination of DEET®, PMD, Picaridin, or other nitrogen containing repellents selected from amines, amides and nitrogen containing heterocyclic compounds.
    Type: Application
    Filed: November 13, 2014
    Publication date: May 14, 2015
    Inventor: Robert H. BEDOUKIAN
  • Patent number: 9023369
    Abstract: The invention relates to freeze-dried molded articles, containing ?50% by wt. of one or more active substances, and ?15% by wt. of one or more scaffold-forming agents, with proteins being excepted, as well as optionally one or more auxiliary substances, in each case based on the total composition of the freeze-dried molded article, whose 1% by wt. solution or suspension in water, at 20° C., has a pH value <7. Furthermore, the invention relates to methods for manufacturing these freeze-dried molded articles, the combination of such freeze-dried molded articles in kit-of-parts arrangements together with aqueous solutions, as well as the use of the freeze-dried molded articles and the kit-of-parts combinations for pharmaceutical and cosmetic application.
    Type: Grant
    Filed: April 20, 2010
    Date of Patent: May 5, 2015
    Inventors: Ralf Malessa, Claudia Elsinghorst, Fabian Kuhlmann, Uwe Wagner
  • Patent number: 9012411
    Abstract: The invention provides novel compounds and formulations of turmeric oil, fish oil, aspirin and anti-cancer drugs (paclitaxel) having anti-inflammatory, analgesic and/or anti-cancer activity.
    Type: Grant
    Filed: June 29, 2012
    Date of Patent: April 21, 2015
    Assignee: Organomed Corporation
    Inventor: James N. Jacob
  • Patent number: 9005626
    Abstract: A liquid composition suitable for topical use comprising is provided that includes a phospholipid foaming agent and at least one solvent; and a pharmaceutically acceptable active agent; wherein the liquid composition is capable of mechanically foaming without an additional propellant; and wherein upon mechanical foaming of 250 ml of the liquid composition results in a foam with a foam volume of at least about 400 ml and a foam stability wherein at least about 50% of the foam volume is still present after about 5 minutes at 25° C., as determined using a SITA foam measurement. Also provided herein are methods of making disclosed compositions and methods of use.
    Type: Grant
    Filed: July 19, 2010
    Date of Patent: April 14, 2015
    Assignee: MIKA Pharma GmbH
    Inventor: Bernd G. Seigfried
  • Publication number: 20150080352
    Abstract: The present invention describes a surprising effect of an aqueous polyurethane dispersion on the efficacy of active ingredients in the anti-acne treatment. The aqueous polyurethane dispersion was able to reduce irritation and substantially enhance efficacy of the salicylic acid and/or salicylic acid derivative in the topical anti-acne serum.
    Type: Application
    Filed: March 6, 2013
    Publication date: March 19, 2015
    Applicants: BAYER MATERIALSCIENCE LLC, BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Sophie Viala, Sebastian Doerr, Yuliya Berezkin
  • Patent number: 8980234
    Abstract: A composition in the form of an oil-in-water emulsion containing: an ester of fatty acid and of polyethylene glycol; an additional surfactant chosen from esters of C16-C22 fatty acid and of sorbitan and esters of C16-C22 fatty acid and of glycerol; a polycondensate of ethylene oxide and of propylene oxide consisting of polyethylene glycol and polypropylene glycol blocks; and an ascorbic acid compound or a salicylic acid compound. The composition has good stability, in particular after hours at 55° C. Application in caring for and making up keratinous substances.
    Type: Grant
    Filed: March 9, 2009
    Date of Patent: March 17, 2015
    Assignee: L'Oreal
    Inventor: Aldo Monello
  • Publication number: 20150071864
    Abstract: A reversely thermo-reversible hydrogel composition comprising a water soluble block copolymer comprising at least two blocks of polyethylene oxide and at least one block of polypropylene oxide, and at least one associative gelling adjuvant having water solubility less than 0.5 g/100 ml, preferably less than 0.3 g/100 ml at 20° C., and being capable of forming water soluble inter-molecular complexes with the water soluble block copolymer in water. The hydrogel composition exhibits improved gelling efficiency, enhanced solubility and/or stability for water sparely soluble and insoluble pharmaceutical agents. The hydrogel compositions are useful in a variety of pharmaceutical and cosmetic products and applications, such as esophageal, otic, vaginal, rectal, ophthalmic, treatments of disorders and imperfections of the skin, and treating and/or preventing alopecia and restoring and/or promoting hair growth.
    Type: Application
    Filed: September 22, 2014
    Publication date: March 12, 2015
    Applicant: Broda Technologies Co., Ltd.
    Inventors: Shao Xiang LU, Jeffrey LU, Letian LIU