With Organic Nitrogen Containing Compound Patents (Class 514/162)
  • Patent number: 10376464
    Abstract: Cocrystal compositions of metoprolol and dabigatran bases with enantiomers of theanine.
    Type: Grant
    Filed: October 3, 2016
    Date of Patent: August 13, 2019
    Assignee: THEAPRIN PHARMACEUTICALS INC.
    Inventors: Harry G. Brittain, Philip V. Felice
  • Patent number: 10101248
    Abstract: This disclosure is directed to a method and an attachment solution for adhering a cytological or histological sample, such as buffy coat, to a substrate, such as a microscope slide. The attachment solution includes an attachment base, an anti-coagulant, and a nonsteroidal anti-inflammatory drug. The attachment base may be an alcohol, an acid, an oxidizer, an organohalogen, a ketone, or any combination thereof. Once a sample is obtained, the sample may be re-suspended in the attachment solution or the attachment solution may be added to the sample. The sample may then be dispensed onto an analysis platform as one or more droplets and cured.
    Type: Grant
    Filed: October 18, 2017
    Date of Patent: October 16, 2018
    Assignee: RareCyte, Inc.
    Inventors: Daniel Campton, Joshua Nordberg, Ronald Seubert
  • Patent number: 9605138
    Abstract: There is provided a resin composition which contains a cellulose ester resin, a polyether ester compound, and an additive if necessary, the resin composition being capable of providing a resin shaped product with excellent transparency, tensile fracture energy property, and the like, and of being suppressed from deterioration of flowability.
    Type: Grant
    Filed: April 28, 2016
    Date of Patent: March 28, 2017
    Assignee: FUJI XEROX CO., LTD.
    Inventors: Kenji Yao, Masahiro Moriyama, Manabu Kawashima, Masaya Ikuno
  • Patent number: 9605139
    Abstract: There is provided a resin composition which contains a cellulose ester resin, a polyether ester compound, and an additive if necessary, the resin composition being capable of providing a resin shaped product with excellent transparency, tensile fracture energy property, and the like, and of being suppressed from deterioration of flowability.
    Type: Grant
    Filed: April 28, 2016
    Date of Patent: March 28, 2017
    Assignee: FUJI XEROX CO., LTD.
    Inventors: Kenji Yao, Masahiro Moriyama, Manabu Kawashima, Masaya Ikuno
  • Patent number: 9605137
    Abstract: There is provided a resin composition which contains a cellulose ester resin, a polyether ester compound, and an additive if necessary, the resin composition being capable of providing a resin shaped product with excellent transparency, tensile fracture energy property, and the like, and of being suppressed from deterioration of flowability.
    Type: Grant
    Filed: April 28, 2016
    Date of Patent: March 28, 2017
    Assignee: FUJI XEROX CO., LTD.
    Inventors: Kenji Yao, Masahiro Moriyama, Manabu Kawashima, Masaya Ikuno
  • Patent number: 9605136
    Abstract: There is provided a resin composition which contains a cellulose ester resin, a polyether ester compound, and an additive if necessary, the resin composition being capable of providing a resin shaped product with excellent transparency, tensile fracture energy property, and the like, and of being suppressed from deterioration of flowability.
    Type: Grant
    Filed: April 28, 2016
    Date of Patent: March 28, 2017
    Assignee: FUJI XEROX CO., LTD.
    Inventors: Kenji Yao, Masahiro Moriyama, Manabu Kawashima, Masaya Ikuno
  • Patent number: 9603937
    Abstract: A platform drug delivery system and a method of improving the delivery of low solubility pharmaceuticals utilizing crystal engineering and Theanine dissolution resulting in enhanced bioactivity, dissolution rate, and solid state stability.
    Type: Grant
    Filed: March 9, 2015
    Date of Patent: March 28, 2017
    Assignee: Theaprin Pharmaceuticals Inc.
    Inventors: Harry G. Brittain, Philip V. Felice
  • Patent number: 9603938
    Abstract: A method of making a water-soluble doxorubicin-theanine cocrystal composition. The method includes the steps of providing a quantity of doxorubicin, adding a quantity of a theanine enantiomer to the quantity of doxorubicin to form a mixture of the quantity of doxorubicin and the enantiomer of theanine, wetting the mixture, and grinding the mixture for a length of time sufficient to produce a dried crystalline mass.
    Type: Grant
    Filed: March 24, 2016
    Date of Patent: March 28, 2017
    Assignee: THEAPRIN PHARMACEUTICALS INC.
    Inventors: Harry G. Brittain, Philip V. Felice
  • Patent number: 9441096
    Abstract: There is provided a resin composition which contains a cellulose ester resin, a polyether ester compound, and an additive if necessary, the resin composition being capable of providing a resin shaped product with excellent transparency, tensile fracture energy property, and the like, and of being suppressed from deterioration of flowability.
    Type: Grant
    Filed: February 2, 2015
    Date of Patent: September 13, 2016
    Assignee: FUJI XEROX CO., LTD.
    Inventors: Kenji Yao, Masahiro Moriyama, Manabu Kawashima, Masaya Ikuno
  • Patent number: 9422701
    Abstract: A toilet water splash inhibiting device for inhibit splashing of toilet water during evacuation of waste into a toilet. The device includes a mixture of liquid body soap, baking soda, vinegar, sodium bicarbonate, aspirin, and anhydrous citric acid.
    Type: Grant
    Filed: October 29, 2014
    Date of Patent: August 23, 2016
    Inventor: Judy C. Martin
  • Patent number: 9403755
    Abstract: The invention relates to a purified Isometheptene compound comprising the structure according to Formula (I), or a hydrochloride, or a pharmaceutically acceptable addition salt thereof. In particular, the disclosure relates to the synthesis, purification and characterization of an Isometheptene isomer mucate crystal 2, wherein the Isometheptene isomer 2 is stereochemically characterized as (R)-enantiomer, respectively. The Isometheptene (R)-enantiomer activity indicates a selective centrally acting selective ligand for Imidazoline subtype 1 (I1) receptor sites; and more specifically, the disclosure provides an antihypertensive composition for treatment of migraine and other neurovascular or neurogenic pain from abdominal distress. (R)-Isometheptene enantiomer or isomer 2 may be an anti-hypertensive agent with lower side effects than the racemate form. Therefore (R)-Isometheptene is believed to be effective against episodic tension-type headaches (ETTH).
    Type: Grant
    Filed: January 17, 2014
    Date of Patent: August 2, 2016
    Assignee: TONIX PHARMA HOLDINGS LIMITED (BERMUDA)
    Inventors: Seth Lederman, Bruce Daugherty, Leland J. Gershell, Darryl Rideout, Andrew Kawasaki
  • Patent number: 9351976
    Abstract: The present invention relates to a pharmaceutical composition comprising sorbitan esters of carboxylic acids that are useful for the delivery of anti-psychotic drugs.
    Type: Grant
    Filed: May 18, 2015
    Date of Patent: May 31, 2016
    Assignee: ALKERMES PHARMA IRELAND LIMITED
    Inventors: Jason M. Perry, Daniel R. Deaver, Magali B. Hickey, Julius F. Remenar, Jennifer Vandiver
  • Patent number: 9155718
    Abstract: The present invention provides a new composition for treating pain-associated sleep disturbances, especially shortened sleep duration, comprising ibuprofen and diphenhydramine. The composition is further prepared as a bilayer tablet or caplet, or alternatively as a soft gelatin capsule composition, to prevent interaction between the active ingredients.
    Type: Grant
    Filed: October 1, 2014
    Date of Patent: October 13, 2015
    Assignee: Wyeth LLC
    Inventors: Graham D. Cook, Todd S. Koch, David H. Giamalva, Justin Bianco, James J. Fort, Geraldine Doyle, Steven Cooper
  • Patent number: 9101591
    Abstract: The present invention provides a gel formulation comprising diclofenac sodium which has superior transdermal flux properties, which may be used for the topical treatment of pain, such as in osteoarthritis.
    Type: Grant
    Filed: January 14, 2015
    Date of Patent: August 11, 2015
    Assignee: HZNP LIMITED
    Inventors: Ed Kisak, Jagat Singh
  • Patent number: 9066913
    Abstract: The present invention provides a gel formulation comprising diclofenac sodium which has superior transdermal flux properties, which may be used for the topical treatment of pain, such as in osteoarthritis.
    Type: Grant
    Filed: September 25, 2014
    Date of Patent: June 30, 2015
    Assignee: HZNP LIMITED
    Inventors: Ed Kisak, Jagat Singh
  • Publication number: 20150133407
    Abstract: The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, and methods for the treatment of respiratory disorders may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of viscid or excessive mucus, cough, inflammation, redness in sore throat, infection in the throat, sore throat, abnormal mucus secretion, impaired mucus transport, allergic rhinitis, asthma, COPD, respiratory muscular disorders and pain in acute sore throat.
    Type: Application
    Filed: May 14, 2013
    Publication date: May 14, 2015
    Inventor: Mahesh Kandula
  • Publication number: 20150133408
    Abstract: The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, and methods for the treatment of fibromyalgia, restless leg syndrome may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of motor neurone disease, diabetic neuropathy, postherpetic neuralgia, acute opioid withdrawal management, obsessive-compulsive disorder, premature ejaculation, PTSD, injury, post-operative pain, osteoarthritis, rheumatoid arthritis, multiple sclerosis, spinal cord injury, migraine, HIV related neuropathic pain, bipolar depression, depression, stress, cancer pain and lower back pain.
    Type: Application
    Filed: February 16, 2013
    Publication date: May 14, 2015
    Inventor: Mahesh KANDULA
  • Publication number: 20150072005
    Abstract: Provided are methods for enhancing the efficacy of aspirin. Also provided are methods for reducing pain or preventing or treating heart attack, stroke or blood clot in a subject in need thereof. The methods entail orally administering to the subject a first composition comprising a first amount of aspirin, and a second composition comprising a second amount of aspirin, wherein the first composition is formulated so as to, upon administration, disintegrate or dissolve intraorally providing rapid release of the aspirin of the first composition in the subject, and wherein the second composition is formulated to be substantially more difficult than the first composition to disintegrate or dissolve intraorally but is ingestible and releasable in the gastrointestinal track of the subject. The method can further include administering to the subject a painkiller or an agent suitable for treating a cardiovascular disease or condition.
    Type: Application
    Filed: September 10, 2013
    Publication date: March 12, 2015
    Inventor: Joseph P. Habboushe
  • Publication number: 20150010599
    Abstract: Methods and compositions for reducing bladder spasms are disclosed. The methods comprise administering to a subject in need thereof a pharmaceutical composition comprising an effective amount of acetaminophen and an effective amount of at least one non-steroidal anti-inflammatory agent (NSAID). In another embodiment, a method for reducing bladder spasms comprising administering to a subject in need thereof a pharmaceutical composition comprising an effective amount of at least one prostaglandin (PG) pathway inhibitor, wherein the at least one PG pathway inhibitor is not acetaminophen or an NSAID.
    Type: Application
    Filed: September 24, 2014
    Publication date: January 8, 2015
    Inventor: David A. DILL
  • Publication number: 20150010496
    Abstract: Disclosed herein are ?-galactosylceramide (?-GalCer) analogs and compositions thereof, methods of activating invariant Natural Killer T (iNKT) cells using said analogs, methods of treating diseases by activating iNKT cells using said analogs, and combination therapy of said analogs.
    Type: Application
    Filed: November 30, 2012
    Publication date: January 8, 2015
    Inventors: Vincenzo Cerundolo, Gurdyal S. Besra, Liam Cox
  • Publication number: 20140357602
    Abstract: This invention is directed to pharmaceutical combinations comprising an antioxidant agent, an anti-inflammatory agent, and optionally at least one other anti-diabetic agent useful for treating metabolic disorders. This invention also encompasses pharmaceutically acceptable compositions comprising an antioxidant agent, an anti-inflammatory agent, optionally at least one other anti-diabetic agent, and at least one pharmaceutically acceptable carrier.
    Type: Application
    Filed: March 14, 2013
    Publication date: December 4, 2014
    Inventors: Eric Mayoux, Luc Marti Clauzel, Silvia Garcia Vicente, Marta Serrano Munoz, Antonio Zorzano Olarte, Alec Mian
  • Publication number: 20140349978
    Abstract: A concentrated salicylic acid gel comprising salicylic acid and a stabilizer compound, wherein the salicylic acid comprises at least 30 wt % of the total weight of the gel.
    Type: Application
    Filed: August 8, 2014
    Publication date: November 27, 2014
    Inventors: Chris Gerlach, Mike Davies
  • Publication number: 20140343021
    Abstract: A method of treating frostbite in a subject using a water-soluble cocrystal composition which contains a quantity of acetylsalicylic acid and a quantity of a theanine enantiomer.
    Type: Application
    Filed: July 31, 2014
    Publication date: November 20, 2014
    Applicant: THEAPRIN PHARMACEUTICALS INC.
    Inventors: Harry G. Brittain, Philip V. Felice
  • Patent number: 8889659
    Abstract: The present invention relates to TRPV1 selective agonist topical compositions including capsaicinoid and analgesic agent compositions and methods of manufacture and methods of providing pain relief as well as treating a variety of disorders with such compositions.
    Type: Grant
    Filed: September 10, 2012
    Date of Patent: November 18, 2014
    Assignee: API Genesis, LLC
    Inventors: Daniel Bucks, Philip J. Birbara
  • Patent number: 8883767
    Abstract: A low ether gel composition for application to skin comprising a keratolytic agent, in particular salicylic acid, and comprising a nitrocellulose and one or more volatile ingredients, which forms a film on contact with skin adequate to form a protective barrier for the keratolytic agent for a period of time necessary to provide treatment to the skin; methods of treating using such compositions, and dispensers containing such compositions.
    Type: Grant
    Filed: October 4, 2010
    Date of Patent: November 11, 2014
    Assignee: MSD Consumer Care, Inc.
    Inventors: Gerald R. Dever, Eric Chen-nan Su, William Scott Rogersr, Robert C. Johnson
  • Publication number: 20140329781
    Abstract: The present invention relates to a once-a-day therapeutically synergistic pharmaceutical dosage form for treatment of cardiovascular disorders, wherein the dosage form comprises a fixed dose combination of metoprolol in extended release form and one or more antiplatelet agent along with one or more rate controlling excipients.
    Type: Application
    Filed: November 1, 2012
    Publication date: November 6, 2014
    Applicant: WOCKHARDT LIMITED
    Inventors: Mandar Kodgule, Amit Gupta, Premchand Nakhat, Girish Kumar Jain
  • Publication number: 20140328934
    Abstract: Disclosed are improved granular pharmaceutical preparations, together with improved methods and apparatus for preparation of granules for use in such preparations. Such methods are especially useful for making granules for solid oral dose pharmaceutical preparations, and are particularly suited to the production of granules comprising 5-aminosalicylic acid (5-ASA) for the treatment of inflammatory bowel disease. The granules exhibit a more sharply peaked length distribution, and hence aspect ratio distribution, and have a consequently much sharper dissolution profile after further processing.
    Type: Application
    Filed: May 16, 2014
    Publication date: November 6, 2014
    Applicant: Ferring B.V.
    Inventors: Carsten Hoeg-Moller, Crilles Casper Larsen, Jorgen Wittendorff, Birgitte Nissen, Kenneth Manby Pedersen, Tue Hansen, Helle Poulsen
  • Publication number: 20140328775
    Abstract: A cosmetic composition suitable for topical application, for example, is provided. In some examples, the cosmetic composition may include batyl alcohol, undecylenoyl phenylalanine, hexyldecanol, and bisabolol. A method of reducing the synthesis of melanin by using the cosmetic compositions is also disclosed herein.
    Type: Application
    Filed: May 1, 2014
    Publication date: November 6, 2014
    Applicant: The Procter & Gamble Company
    Inventors: Leo Timothy LAUGHLIN, II, Tomohiro HAKOZAKI, Shuhei TANAKA
  • Publication number: 20140323445
    Abstract: A salicylic acid gel contains salicylic acid, a thickener, and a stabilizer compound. The gel may be diluted and/or incorporated into final skin care products.
    Type: Application
    Filed: July 11, 2014
    Publication date: October 30, 2014
    Inventors: Chris Gerlach, Mike Davies
  • Publication number: 20140296189
    Abstract: A method of reducing niacin flushing in a subject using a water-soluble cocrystal composition which contains a quantity of acetylsalicylic acid and a quantity of a theanine enantiomer.
    Type: Application
    Filed: May 21, 2014
    Publication date: October 2, 2014
    Applicant: THEAPRIN PHARMACEUTICALS INC.
    Inventors: Harry G. Brittain, Philip V. Felice
  • Publication number: 20140286931
    Abstract: The present invention relates to new biphenyl-3-carboxylic acid modulators of beta-3-adrenoceptor activity, pharmaceutical compositions thereof, and methods of use thereof.
    Type: Application
    Filed: June 5, 2014
    Publication date: September 25, 2014
    Inventor: Chengzhi Zhang
  • Publication number: 20140288029
    Abstract: A method of treating myocardial infarction in a subject using a water-soluble cocrystal composition which contains a quantity of acetylsalicylic acid and a quantity of a theanine enantiomer.
    Type: Application
    Filed: June 4, 2014
    Publication date: September 25, 2014
    Applicant: THEAPRIN PHARMACEUTICALS INC.
    Inventors: Harry G. Brittain, Philip V. Felice
  • Patent number: 8834857
    Abstract: A method for cleaning, benefiting, or deodorizing skin or hair utilizing a body wash, skin cleaner, soap, shampoo or deodorizer formulation containing a controlled release skin benefit or deodorizing salt, a hydrophilic moisturizing polymer and surfactants is described. The method imparts benefits or deodorizing agents to the skin or hair and maintains effective levels for an extended period.
    Type: Grant
    Filed: January 18, 2012
    Date of Patent: September 16, 2014
    Assignee: Nevada Naturals Inc.
    Inventors: Anthony E. Winston, Richard F. Stockel, Anthony Joseph Sawyer
  • Patent number: 8828979
    Abstract: A concentrated salicylic acid gel comprising salicylic acid and a stabilizer compound, wherein the salicylic acid comprises at least 30 wt % of the total weight of the gel.
    Type: Grant
    Filed: March 8, 2013
    Date of Patent: September 9, 2014
    Assignee: Essential Ingredients, Inc.
    Inventors: Chris Gerlach, Mike Davies
  • Patent number: 8821905
    Abstract: The present invention provides an oil-in-water emulsified composition comprising the following ingredients (A)-(G) characterized by miniaturization of the emulsified particles by means of high pressure emulsification: (A) salt type drug (B) hydrophilic nonionic surfactant (C) N-long chain acyl acidic amino acid mono salt (D) two or more types of higher fatty acids and alkali that constitutes higher fatty acid soap (E) higher alcohol (F) oil component (G) water. The object of the present invention is to provide an oil-in-water emulsified composition prepared by miniaturizing emulsified particles by means of a high pressure emulsification method, said composition being superior in terms of emulsification stability such that electrolyte salt type drugs can be stably blended in.
    Type: Grant
    Filed: October 4, 2011
    Date of Patent: September 2, 2014
    Assignee: Shiseido Company, Ltd.
    Inventor: Takumi Watanabe
  • Publication number: 20140235594
    Abstract: A method of treating a condition associated with excess gluatame in a subject using a water-soluble cocrystal composition which contains a quantity of acetylsalicylic acid and a quantity of a theanine enantiomer.
    Type: Application
    Filed: April 25, 2014
    Publication date: August 21, 2014
    Applicant: THEAPRIN PHARMACEUTICALS INC.
    Inventors: Harry G. Brittain, Philip V. Felice
  • Patent number: 8808755
    Abstract: A skin disinfectant in ready-to-use concentrated liquid or dry powdered form. Ready-to-use liquid forms have a pH of from about 2 to about 6 and include: (a) hydrogen peroxide in a concentration of from about 0.01 to about 4% w/w of the solution; (b) at least one surfactant chosen from imidazoline derivatives, alkyl betaines, alkyl amidopropyl betaine amides, alkyl amidopropyl betaines, alkylsulfo betaines, amine oxides and derivatives thereof in a concentration of from about 0.01 to about 15% w/w of the solution; (c) at least one hydrogen peroxide stabilizer in a concentration of from about 0.01 to about 4% w/w of the solution; (d) at least one member chosen from cyclic carboxylic acids and salts thereof in a concentration of from about 0.01 to about 4% w/w of the solution; and (e) at least one skin conditioning agent in a concentration of from about 0.01 to about 10% w/w of the solution.
    Type: Grant
    Filed: February 8, 2011
    Date of Patent: August 19, 2014
    Assignee: Virox Technologies Inc.
    Inventor: Navid Omidbakhsh
  • Patent number: 8802736
    Abstract: The present invention relates to a composition useful for pain relief. The composition is high concentration capsaicinoid topical composition comprising an analgesic agent that eliminates or reduces the burning or stinging sensation or erythema of the capsaicinoid.
    Type: Grant
    Filed: March 12, 2013
    Date of Patent: August 12, 2014
    Assignee: API Genesis, LLC
    Inventors: Daniel Bucks, Philip J. Birbara
  • Publication number: 20140178447
    Abstract: Disclosed herein are methods and compositions for rendering medical devices and other surfaces biofilm resistant by the use of a coating composition comprising a combination of one or more antimicrobial agent, one or more anti-inflammatory agent, optionally a releasing agent, optionally decandediol, and a lubricious matrix system comprising a biomedical polymer. In certain embodiments said coating composition is adhered to the device or surface by a coating comprising urethane and silicone adhesives.
    Type: Application
    Filed: February 28, 2014
    Publication date: June 26, 2014
    Inventors: Shanta M. Modak, Ronald Citron, Santoshkumar Dongre, Nayana Baiju, Arnab Kumar Ghosh
  • Publication number: 20140179643
    Abstract: Methods for preventing, ameliorating, or reducing dermatological signs of aging are provided which employ a composition comprising an effective amount of N-Acetyl-Tyrosinamide and an effective amount of a retinoid, in a cosmetically acceptable vehicle, for topical application to the skin for a time sufficient to improve the appearance of said skin.
    Type: Application
    Filed: December 20, 2012
    Publication date: June 26, 2014
    Applicant: AVON PRODUCTS, INC.
    Inventors: Uma Santhanam, Permanan Raaj Khusial
  • Publication number: 20140179644
    Abstract: A method of reducing hepatocellular damage in a subject using a water-soluble cocrystal composition which contains a quantity of acetylsalicylic acid and a quantity of a theanine enantiomer.
    Type: Application
    Filed: February 25, 2014
    Publication date: June 26, 2014
    Applicant: THEAPRIN PHARMACEUTICALS INC.
    Inventors: Harry G. Brittain, Philip V. Felice
  • Patent number: 8759325
    Abstract: Inflammatory bowel diseases are represented by two idiopathic disorders, which include ulcerative colitis and Crohn's disease. Ulcerative colitis is restricted to the colon and involves uncertain and inflammation of the lining (mucosa) of the large intestine. Crohn's disease, on the other hand, can involve the mucosa of the small and/or large intestine and may involve deeper layers of the bowel wall. The present invention is a combination of 5-aminosalicylic acid and one or more antioxidants (e.g., N-acetylcysteine) for treating such inflammatory bowel diseases.
    Type: Grant
    Filed: February 21, 2012
    Date of Patent: June 24, 2014
    Assignee: The Regents of the University of Oklahoma
    Inventor: Richard F. Harty
  • Publication number: 20140161868
    Abstract: A transdermal delivery kit that enhances the efficacy of a topical drug includes at least one drug dispensing device, a lipophilic base, a hydrophilic base, a lipid-soluble active ingredient, a water-soluble active ingredient, a first container for mixing the lipophilic base with the lipid-soluble active ingredient to form a first compound, a second container for mixing the hydrophilic base with the water-soluble active ingredient to form a second compound, a mixing member, and instructions for compounding the lipophilic base with the lipid-soluble active ingredient to form the first compound, compounding the hydrophilic base with the water-soluble active ingredient to form the second compound, and mixing the first compound and the second compound to form a transdermal pharmaceutical delivery system capable of delivering a drug to the dermal layer of the skin.
    Type: Application
    Filed: February 12, 2014
    Publication date: June 12, 2014
    Applicant: GENSCO LABORATORIES LLC
    Inventors: Carlos A. Alfaras, Paul M. Zimmerman, Urbano Zamora
  • Publication number: 20140154314
    Abstract: Methods and compositions for reducing the frequency of urination are disclosed. One method comprises administering to a subject in need thereof an effective amount of a pharmaceutical composition comprising an analgesic agent formulated in a delayed-release formulation. Another method comprises administering to a subject in need thereof an effective amount of a pharmaceutical composition comprising multiple active ingredients. Yet another method comprises administering to a subject in need thereof an effective amount of a diuretic followed with another administration of a pharmaceutical composition comprising an analgesic agent.
    Type: Application
    Filed: February 7, 2014
    Publication date: June 5, 2014
    Applicant: WELLESLEY PHARMACEUTICALS, LLC
    Inventor: David A. DILL
  • Publication number: 20140154189
    Abstract: The present invention, therefore, is directed to an antimicrobial compositions that decreases the bioavailability of iron by introducing a higher-affinity iron-selective chelating agent capable of competing with microbial siderophores. In one aspect, the present invention relates to an antimicrobial composition including a potentiating antimicrobial composition including one or more antimicrobial agents and a chelator having a weight ratio of the antimicrobial agent to the chelator from about 1:1000 to about 1000:1.
    Type: Application
    Filed: October 14, 2013
    Publication date: June 5, 2014
    Applicant: Arch Chemicals, Inc.
    Inventors: George Polson, Jody Jourden, Qi Zheng, Regina M. Prioli, Diana Ciccognani, Sungmee Choi
  • Publication number: 20140155349
    Abstract: The use of a pharmaceutical regimen to deter in an individual, as the individual ages, the development of a cardiovascular disease (CVD) or Alzheimer's disease or to treat an individual who has CVD or Alzheimer's, the individual ingesting on a daily basis a regimen comprising pharmaceutically effective amounts of magnesium salicylate and naproxen, the amount of the magnesium salicylate being no greater than about 260 mg, and also the use of a pharmaceutical regimen to treat an individual who has Type 2 diabetes, the regimen being ingested daily by the individual and comprising pharmaceutically effective amounts of at least one glucose-lowering drug and magnesium salicylate in an amount no greater than about 260 mg.
    Type: Application
    Filed: June 10, 2013
    Publication date: June 5, 2014
    Inventors: Anthony I. Rozmanith, Jolan S. Rozmanith
  • Publication number: 20140154275
    Abstract: The present invention relates to methods of gene expression profiling for inflammatory bowel disease pathogenesis, in which the differential expression in a test sample from a mammalian subject of one or more IBD markers relative to a control is determined, wherein the differential expression in the test sample is indicative of an IBD in the mammalian subject from which the test sample was obtained.
    Type: Application
    Filed: September 6, 2013
    Publication date: June 5, 2014
    Applicant: GENENTECH, INC.
    Inventors: Alexander R. Abbas, Hilary Clark, Lauri Diehl, Charles Lees, Colin L. Noble, Jack Satsangi
  • Publication number: 20140154320
    Abstract: Methods and compositions for reducing the frequency of urination are disclosed. One method comprises administering to a subject in need thereof an effective amount of a pharmaceutical composition comprising an analgesic agent formulated in an extended-release formulation. Another method comprises administering to a subject in need thereof an effective amount of a pharmaceutical composition comprising multiple active ingredients formulated for extended-release. Yet another method comprises administering to a subject in need thereof an effective amount of a diuretic followed with another administration of a pharmaceutical composition comprising an analgesic agent formulated for extended-release.
    Type: Application
    Filed: February 4, 2014
    Publication date: June 5, 2014
    Applicant: WELLESLEY PHARMACEUTICALS, LLC
    Inventor: David A. DILL
  • Publication number: 20140148418
    Abstract: A method of treating high grade temperature using a water-soluble cocrystal composition contains a quantity of acetylsalicylic acid and a quantity of a theanine enantiomer selected from an alpha variant of theanine or a beta variant of theanine or other form of theanine.
    Type: Application
    Filed: January 31, 2014
    Publication date: May 29, 2014
    Applicant: THEAPRIN PHARMACEUTICALS INC.
    Inventors: Harry G. Brittain, Philip V. Felice
  • Publication number: 20140147448
    Abstract: The invention includes compositions and methods useful for treating preventing abnormal thrombus formation and subsequent cardiovascular disease in diabetic patients and patients with increased cardiovascular risk.
    Type: Application
    Filed: June 5, 2012
    Publication date: May 29, 2014
    Applicant: Yale University
    Inventors: John Hwa, WaiHo Tang