Abstract: Methods for sedating, anaesthetising and/or euthanising aquatic organisms, wherein the organism is contacted with methyl salicylate, ethyl salicylate or both, usually in solution. Active compositions for use in such methods are also provided, including compositions containing one or both of methyl salicylate and ethyl salicylate in combination with one or both of eugenol and iso-eugenol.
Type:
Grant
Filed:
October 10, 1997
Date of Patent:
July 25, 2000
Assignee:
New Zealand Institute for Crop & Food Research Limited
Abstract: The present invention provides an composition for attracting noctuid and/or other lepidopteran species. Liquid and solid formulations are provided, along with methods for their use, for controlling or eliminating noctuid and/or other lepidopteran species, and/or protecting plants susceptible to noctuid and/or other lepidopteran species damage.
Type:
Grant
Filed:
October 5, 1998
Date of Patent:
June 13, 2000
Assignee:
The United States of America as represented by the Secretary of Agriculture
Inventors:
Juan D. Lopez, Jr., Ted N. Shaver, Kenneth R. Beerwinkle, Peter D. Lingren
Abstract: Nonsteroidal antiinflammatory drugs which have been substituted with a nitrogen monoxide group; compositions comprising (i) a nonsteroidal antiinflammatory drug, which can optionally be substituted with a nitrogen monoxide group and (ii) a compound that directly donates, transfers or releases a nitrogen monoxide group (preferably as a charged species, particularly nitrosonium); and methods of treatment of inflammation, pain, gastrointestinal lesions and/or fever using the compositions are disclosed The compounds and compositions protect against the gastrointestinal, renal and other toxicities that are otherwise induced by nonsteroidal antiinflammatory drugs.
Type:
Grant
Filed:
January 22, 1999
Date of Patent:
March 28, 2000
Assignee:
NitroMed, Inc.
Inventors:
David S. Garvey, L. Gordon Letts, H. Burt Renfroe, Sang William Tam
Abstract: A compound comprising a non-steroidal antiinflammatory agent to which is directly or indirectly linked an NO group, a compound comprising an enolic anilide non-steroidal antiinflammatory agent to which is directly or indirectly linked an NO.sub.2 group, a pharmaceutical composition including the compounds and methods of treatment of pain and/or inflammation using the compounds and compositions are disclosed. Also disclosed is a composition comprising a non-steroidal antiinflammatory agent and a compound that donates, transfers or releases nitric oxide.
Type:
Grant
Filed:
January 22, 1999
Date of Patent:
March 28, 2000
Assignee:
NitroMed, Inc.
Inventors:
David S. Garvey, L. Gordon Letts, H. Burt Renfroe, Sang William Tam
Abstract: The present invention relates, in general, to a method of preventing or delaying the onset of Alzheimer's disease and related neurodegenerative disorders. The invention also relates to a method of treating Alzheimer's disease and related neurodegenerative disorders so as to ameliorate the further progress of symptoms. The methods involve the administration of a non-steroidal anti-inflammatory agent and/or a histamine H2 receptor blocking agent. According to indication, the present method can be applied to individuals who are currently asymptomatic but at risk of developing Alzheimer's disease, to individuals who have mild cognitive symptoms that may either denote an incipient prodrome of Alzheimer's disease or represent early symptoms (prodromal stage), or to individuals who have a clinical diagnosis of Alzheimer's disease.
Type:
Grant
Filed:
April 14, 1997
Date of Patent:
February 15, 2000
Assignee:
Duke University
Inventors:
John C. S. Breitner, Kathleen A. Welsh-Bohmer
Abstract: An extract composition derived from the peel of a banana and the method for producing the extract composition. An aqueous solvent is combined with the peel of a banana. If the banana is unripe, a base is also added. The mixture is homogenized and allowed to react at least until a black supernatant appears. The entire slurry is filtered. The resulting extract is used alone or combined with a cream or ointment. Medicinal benefits of the extract include relief from pain, swelling, itching, bruising, wrinkles, and sunburn.
Abstract: A pharmaceutical, orally applicable composition is described, whereby the solid composition contains at least one active ingredient, at least one disintegrant, as well as at least one usual pharmaceutical additional ingredient. Furthermore said composition contains at least one ingredient that accelerates the decomposition of said composition in the mouth or in a liquid, whereby said ingredient is a water-soluble amino acid, a water-soluble amino acid derivative and/or a water-soluble amino acid salt.
Abstract: According to one embodiment of the topical therapeutic composition of the present invention, the composition comprises a combination of sulfur and Vitamin E in a range of about three parts of Vitamin E to one part sulfur to about equal parts of sulfur and Vitamin E. Preferably, the sulfur is in powder form, for example, sublimed sulfur, prior to mixing with the Vitamin E. The Vitamin E comprises either natural vitamin E (d-alpha tocopherol) or synthetic vitamin E (dl-alpha tocopherol) or a blend of both natural vitamin E (d-alpha tocopherol) and synthetic vitamin E (dl-alpha tocopherol).
Abstract: An extract composition derived from the peel of a banana and the method for producing the extract composition. An aqueous solvent is combined with the peel of a banana. If the banana is unripe, a base is also added. The mixture is homogenized and allowed to react at least until a black supernatant appears. The entire slurry is filtered. The resulting extract is used alone or combined with a cream or ointment. Medicinal benefits of the extract include relief from pain, swelling, itching, bruising, wrinkles, and sunburn.
Abstract: Compositions for pain relieving non-steroidal anti-inflammatory drugs and/or medicaments such as ibuprofen, methotrexate, capsaicin, diphenhydramine, aspirin, methyl-nicotinate and other medicaments largely soluble in oil, alcohol, and/or water, are produced for transdermal delivery. The composition is manufactured by admixing an appropriate amount of oil surfactant with an appropriate amount of pharmaceutically approved co-solubilizer alcohol to establish a non aqueous phase. The oil surfactant may be a polyethoxylated oil such as castor oil. The co-solubilizer solubilizer may be isopropyl alcohol or virtually any other alcohols except for methanol. Thereafter, an appropriate amount of distilled water is slowly added to the homogeneous or non-aqueous phase to further reduce viscosity. The final admixture is a clear, oil-continuous solution having a viscosity no greater than 850 centistokes as measured by the VST Hoppler method at 25 degrees Celsius.
Abstract: The invention relates to novel compounds of the organosiloxane and organosilane type, bearing at least one function derived from salicylic acid. These novel products have, in particular, desquamating and/or anti-aging properties and may be used in topical application.
Abstract: One or more formulations for treating psoriasis and other skin disorders characterized by redness, itching, flaking, scaling, and plaque-type growth. The formulation includes a carrier component, one or more active ingredient components, and a surfactant component. The carrier preferably includes an alcohol in substantially equal volume with isopropyl myristate. The active ingredient component preferably includes a superpotent or high-potency corticosteroid such as clobetasol propionate, an anti-flaking ingredient such as zinc pyrithione, or a combination of the two. It may also include an anti-fungal compound. The surfactant component preferably includes an alkyl sulfate such as sodium lauryl sulfate. The formulations made by applied topically either in spray form or as a direct-contact liquid.
Abstract: An extract composition derived from the peel of a banana and the method for producing the extract composition. An aqueous solvent is combined with the peel of a banana. If the banana is unripe, a base is also added. The mixture is homogenized and allowed to react at least until a black supernatant appears. The entire slurry is filtered. The resulting extract is used alone or combined with a cream or ointment. Medicinal benefits of the extract include relief from pain, swelling, itching, bruising, wrinkles, and sunburn.
Abstract: The present invention relates to a method for regulating wrinkles and/or atrophy in mammalian skin comprising treating the skin with a safe and effective amount of salicylic acid and/or additional active component.
Abstract: The present invention comprises methods and compositions for topically treating and moisturizing keratinous structures of humans and animals including skin, hair, fingernails, toenails, hooves, and horns.
Abstract: The subject invention encompasses methods for the prevention and treatment of a human or lower animal subject having a gastrointestinal disorder caused or mediated by one or more intestinal helminths comprising administering bismuth to the subject.
Abstract: The present invention is directed to aminoquinolines of Formula I: ##STR1## (wherein R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-1, CCR-2, CCR-2A, CCR-2B, CCR-3, CCR-4, CCR-5, CXCR-3, and/or CXCR-4.
Abstract: The invention relates to novel compounds of the organosiloxane and organosilane type, bearing at least one function derived from salicylic acid. These novel products have, in particular, desquamating and/or anti-aging properties and may be used in topical application.
Abstract: A method for the treatment of acne and/or the effects of ageing, by administering, to a subject in need thereof, a composition containing an effective amount of at least one HMG-Coenzyme A-reductase inhibitor in a carrier that is selected from the group consisting of dermatologically acceptable carriers, cosmetically acceptable carriers, and mixtures thereof, and the compositions for performing the method are provided.
Abstract: The invention relates to novel compounds of the organosiloxane and organosilane type, bearing at least one function derived from salicylic acid. These novel products have, in particular, desquamating and/or anti-aging properties and may be used in topical application.
Abstract: The present invention relates to a composition for regulating wrinkles and/or atrophy in mammalian skin comprising treating the skin with a safe and effective amount of salicylic acid and/or additional active component.
Type:
Grant
Filed:
April 20, 1998
Date of Patent:
March 16, 1999
Assignee:
The Procter & Gamble Company
Inventors:
Roy Lonnie Blank, Darrell Gene Doughty, Carlos Gabriel Linares
Abstract: The present invention relates to a method for regulating wrinkles and/or atrophy in mammalian skin comprising treating the skin with a safe and effective amount of salicylic acid and/or additional active component.
Abstract: The present invention relates to a composition for regulating wrinkles and/or atrophy in mammalian skin comprising treating the skin with a safe and effective amount of salicylic acid and/or additional active component.
Type:
Grant
Filed:
August 29, 1997
Date of Patent:
February 9, 1999
Assignee:
The Procter & Gamble Company
Inventors:
Roy Lonnie Blank, Darrell Gene Doughty, Carlos Gabriel Linares
Abstract: A method and composition is provided for treating skin to achieve lightening by employing an active of the structure: ##STR1## wherein R is selected from the group consisting of C.sub.1 -C.sub.30 alkyl, cycloalkyl and aryl radicals. Most preferred is acetaminophen.
Type:
Grant
Filed:
December 4, 1997
Date of Patent:
January 12, 1999
Assignee:
Chesebrough-Pond's USA Co., Division of Conopco, Inc.
Inventors:
Brian Andrew Crotty, Alexander Paul Znaiden, Anthony Johnson
Abstract: The subject invention relates to desquamation compositions comprising a combination of salicylic acid and certain zwitterionic surfactants. The subject invention further relates to methods of desquamation in mammalian skin and treating acne in mammalian skin.
Abstract: A skin blemish treatment combines a base with therapeutically effective amounts of carbamide peroxide and alpha-hydroxy acid ("AHA"). The resulting formulation effectively treats human acne vulgaris while exhibiting none of the severe adverse side effects associated with benzoyl peroxide. The AHA can be any synthetic or naturally occurring alpha-hydroxy acid. Salicylic acid can augment the composition, as can an anti-inflammatory such as allantoin. Fragrance, coloring agents, and preservatives can also be added.
Abstract: The present invention relates to a method for regulating wrinkles and/or atrophy in mammalian skin comprising treating the skin with a safe and effective amount of salicylic acid and/or additional active component.
Abstract: The present invention relates to a method for regulating wrinkles and/or atrophy in mammalian skin comprising treating the skin with a safe and effective amount of salicylic acid and/or additional active component.
Abstract: The present invention relates to a composition for regulating wrinkles and/or atrophy in mammalian skin comprising treating the skin with a safe and effective amount of salicylic acid and/or additional active component.
Type:
Grant
Filed:
December 16, 1996
Date of Patent:
November 17, 1998
Assignee:
The Procter & Gamble Company
Inventors:
Roy Lonnie Blank, Darrell Gene Doughty, Carlos Gabriel Linares
Abstract: The present invention relates to leave on, oil-in-water, skin care compositions, comprising: (A) from about 0.05% to about 20% of an acidic active ingredient, preferably having a solubility parameter from about 6 to about 12; (B) from about 0.1% to about 25% of alkoxylated alcohols, alkoxylated polyols, and mixtures thereof; (C) from about 1% to about 20% of an acid stable, hydrophobic, structuring agent selected from the group consisting of saturated C.sub.16 to C.sub.30 fatty alcohols, saturated C.sub.16 to C.sub.30 fatty alcohols containing from about 1 to about 5 moles of ethylene oxide, saturated C.sub.16 to C.sub.30 diols, saturated C.sub.16 to C.sub.30 monoglycerol ethers, saturated C.sub.16 to C.sub.30 hydroxy fatty acids, and mixtures thereof, having a melting point of at least about 45.degree. C.; (D) from about 0.
Type:
Grant
Filed:
December 21, 1995
Date of Patent:
October 20, 1998
Assignee:
The Procter & Gamble Company
Inventors:
George Endel Deckner, Marie Antoinette Rinaldi, Victoria Claire Szymanski
Abstract: The present invention relates to a composition for regulating wrinkles and/or atrophy in mammalian skin comprising treating the skin with a safe and effective amount of salicylic acid and/or additional active component.
Type:
Grant
Filed:
December 16, 1996
Date of Patent:
September 22, 1998
Assignee:
The Procter & Gamble Company
Inventors:
Roy Lonnie Blank, Darrell Gene Doughty, Carlos Gabriel Linares
Abstract: The present invention relates to a composition for regulating wrinkles and/or atrophy in mammalian skin comprising treating the skin with a safe and effective amount of salicylic acid and/or additional active component.
Type:
Grant
Filed:
August 29, 1997
Date of Patent:
September 8, 1998
Assignee:
The Procter & Gamble Company
Inventors:
Roy Lonnie Blank, Darrell Gene Doughty, Carlos Gabriel Linares
Abstract: The present invention relates to a method for regulating wrinkles and/or atrophy in mammalian skin comprising treating the skin with a safe and effective amount of salicylic acid and/or additional active component.
Abstract: The present invention relates to a method for regulating wrinkles and/or atrophy in mammalian skin comprising treating the skin with a safe and effective amount of salicylic acid and/or additional active component.
Abstract: The present invention relates to a composition for regulating wrinkles and/or atrophy in mammalian skin comprising treating the skin with a safe and effective amount of salicylic acid and/or additional active component.
Type:
Grant
Filed:
August 29, 1997
Date of Patent:
August 4, 1998
Assignee:
The Procter & Gamble Company
Inventors:
Roy Lonnie Blank, Darrell Gene Doughty, Carlos Gabriel Linares
Abstract: The present invention relates to a method for regulating wrinkles and/or atrophy in mammalian skin comprising treating the skin with a safe and effective amount of salicylic acid and/or additional active component.
Abstract: The present invention relates to a composition for regulating wrinkles and/or atrophy in mammalian skin comprising treating the skin with a safe and effective amount of salicylic acid and/or additional active component.
Type:
Grant
Filed:
August 29, 1997
Date of Patent:
July 28, 1998
Assignee:
The Procter & Gamble Company
Inventors:
Roy Lonnie Blank, Darrell Gene Doughty, Carlos Gabriel Linares
Abstract: The present invention relates to a method for regulating wrinkles and/or atrophy in mammalian skin comprising treating the skin with a safe and effective amount of salicylic acid and/or additional active component.
Abstract: The present invention relates to a method for regulating wrinkles and/or atrophy in mammalian skin comprising treating the skin with a safe and effective amount of salicylic acid and/or additional active component.
Abstract: The present invention relates to a composition for regulating wrinkles and/or atrophy in mammalian skin comprising treating the skin with a safe and effective amount of salicylic acid and/or additional active component.
Type:
Grant
Filed:
August 29, 1997
Date of Patent:
July 14, 1998
Assignee:
The Procter & Gamble Company
Inventors:
Roy Lonnie Blank, Darrell Gene Doughty, Carlos Gabriel Linares
Abstract: The present invention relates to a method for regulating wrinkles and/or atrophy in mammalian skin comprising treating the skin with a safe and effective amount of salicylic acid and/or additional active component.
Abstract: The present invention relates to a composition for regulating wrinkles and/or atrophy in mammalian skin comprising treating the skin with a safe and effective amount of salicylic acid and/or additional active component.
Type:
Grant
Filed:
December 16, 1996
Date of Patent:
July 7, 1998
Assignee:
The Procter & Gamble Company
Inventors:
Roy Lonnie Blank, Darrell Gene Doughty, Carlos Gabriel Linares
Abstract: The present invention relates to a composition for regulating wrinkles and/or atrophy in mammalian skin comprising treating the skin with a safe and effective amount of salicylic acid and/or additional active component.
Type:
Grant
Filed:
December 16, 1996
Date of Patent:
July 7, 1998
Assignee:
The Procter & Gamble Company
Inventors:
Roy Lonnie Blank, Darrell Gene Doughty, Carlos Gabriel Linares
Abstract: A method is provided for inhibiting oil and grease generation from human skin by applying to the skin a C.sub.11 -C.sub.30 alkyl or alkenyl ester of salicylic acid as an active component in combination with a pharmaceutically acceptable carrier. Most preferred is tridecyl salicylate.
Type:
Grant
Filed:
November 27, 1996
Date of Patent:
June 30, 1998
Assignee:
Elizabeth Arden Co., Division of Conopco, Inc.
Inventors:
John Steven Bajor, Angel Augusto Guerrero, Helen Elizabeth Knaggs
Abstract: The present invention relates to an acidic effervescent component for direct tableting of effervescent tablets and a process for its preparation.
Type:
Grant
Filed:
July 26, 1993
Date of Patent:
June 9, 1998
Assignee:
Bayer Aktiengesellschaft
Inventors:
Joachim Maasz, Christian Fritsch, Werner Grawingholt, Bernhard Streuff, Georg Frank
Abstract: Cosmetic skin conditioning compositions containing a salicyloxo .alpha.-carboxy acid. The inventive compositions provide control of sebum secretion from sebocytes, improved oil control and improved skin feel, prevent shine and stickiness, while also providing anti-aging benefits which results in reduced appearance of wrinkles and aged skin, improved skin color, treatment of photoaged skin, improvement in skin's radiance and clarity and finish, and an overall healthy and youthful appearance of the skin.
Type:
Grant
Filed:
May 9, 1997
Date of Patent:
June 9, 1998
Assignee:
Elizabeth Arden Co., Division of Conopco, Inc.
Inventors:
Angel Augusto Guerrero, Joseph Michael Corey
Abstract: The present invention relates to a method for regulating wrinkles and/or atrophy in mammalian skin comprising treating the skin with a safe and effective amount of salicylic acid and/or additional active component.
Abstract: A topical composition comprising:(a) A mixture of water, glycerin and propylene glycol;(b) Homopolymer of acrylic acid crosslinked with an allyl ether of pentaerythritol, and allyl ether of sucrose, or an allyl ether of propylene.(c) Isopropyl alcohol;(d) Acetylsalicylic acid and ethyl alcohol denatured with t-butyl alcohol and a combination of two or three of the following: brucine (alkaloid), brucine sulfate or quassin; and(e) Polymer of ethylene oxide that conforms to the formula: H(OCH.sub.2 CH.sub.2)n OH; wherein n has an average value of 8.
Abstract: A method for the treatment of acne and/or the effects of ageing, by administering, to a subject in need thereof, a composition containing an effective amount of at least one HMG-Coenzyme A-reductase inhibitor in a carrier that is selected from the group consisting of dermatologically acceptable carriers, cosmetically acceptable carriers, and mixtures thereof, and the compositions for performing the method are provided.