With Additional Ortho-hydroxybenzoic Acid Compound Patents (Class 514/160)
-
Patent number: 7638507Abstract: Inflammatory bowel diseases are represented by two idiopathic disorders, which include ulcerative colitis and Crohn's disease. Ulcerative colitis is restricted to the colon and involves uncertain and inflammation of the lining (mucosa) of the large intestine. Crohn's disease, on the other hand, can involve the mucosa of the small and/or large intestine and may involve deeper layers of the bowel wall. The present invention is a combination of 5-aminosalicylic acid and one or more antioxidants (e.g., N-acetylcysteine) for treating such inflammatory bowel diseases.Type: GrantFiled: February 2, 2006Date of Patent: December 29, 2009Assignee: The Board of Regents of the University of OklahomaInventor: Richard F. Harty
-
Patent number: 7608642Abstract: The invention provides compositions and methods that employ compounds that can promote skin cell renewal, wound healing, proliferation of fibroblasts and/or keratinocytes, and production of collagen or fibronectin by fibroblasts. These compositions and methods are useful for rejuvenating the skin and for treating wounds as well as gum-related and skin-related conditions.Type: GrantFiled: June 17, 2003Date of Patent: October 27, 2009Assignee: Kimberly-Clark Worldwide, Inc.Inventor: Sohail Malik
-
Patent number: 7605150Abstract: Administering an effective dose of a tTGase inhibitor to a Celiac or dermatitis herpetiformis patient reduces the toxic effects of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten.Type: GrantFiled: May 14, 2003Date of Patent: October 20, 2009Assignee: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Chaitan Khosla, Felix Hausch
-
Patent number: 7417037Abstract: Inflammatory bowel diseases are represented by two idiopathic disorders, which include ulcerative colitis and Crohn's disease. Ulcerative colitis is restricted to the colon and involves uncertain and inflammation of the lining (mucosa) of the large intestine. Crohn's disease, on the other hand, can involve the mucosa of the small and/or large intestine and may involve deeper layers of the bowel wall. The present invention is a combination of 5-aminosalicylic acid and one or more antioxidants (e.g., N-acetylcysteine) for treating such inflammatory bowel diseases.Type: GrantFiled: December 28, 2004Date of Patent: August 26, 2008Assignee: The Board of Regents of the University of OklahomaInventor: Richard F. Harty
-
Patent number: 7183269Abstract: According to the invention, compositions are made available which have a strong cytotoxic effect which is largely selective on tumor tissue. The invention is based on the fact that certain benzoic acid derivatives have a strong synergistic effect as a mixture and destroy cancer cells selectively in a pH range of 7 or below, such as from 6.5 to 7.Type: GrantFiled: November 17, 2003Date of Patent: February 27, 2007Inventor: Werner Kreutz
-
Patent number: 7098189Abstract: The invention provides compositions and methods that employ compounds that can stimulate proliferation of fibroblasts or keratinocytes and/or stimulate production of collagen by fibroblasts. These compositions and methods are useful for treating gum- and skin-related conditions.Type: GrantFiled: December 16, 2002Date of Patent: August 29, 2006Assignee: Kimberly-Clark Worldwide, Inc.Inventor: Sohail Malik
-
Patent number: 7094431Abstract: This invention pertains to therapeutic antibacterial/antifungal-wound healing compositions comprising a therapeutically effective amount of antibacterial agents and/or antifungal agents and/or wound healing composition alone. In one embodiment, the wound healing composition comprises (a) zinc oxide; (b) calcium channel blocker, and (c) fat-soluble vitamins admixed with antibacterial and antifungal agents. The therapeutic antibacterial/antifungal-wound healing compositions may be utilized in a wide variety of pharmaceutical products and administered orally or topically.Type: GrantFiled: September 30, 2003Date of Patent: August 22, 2006Inventor: Mickey L. Peshoff
-
Patent number: 6906193Abstract: Compounds useful for the treatment of pain in accord with the following structural diagram, wherein R1, R2, R3, R4 and R5 are any of a number of groups as defined in the specification, A and D are as defined in the specification, and pharmaceutical compositions and methods of treatment utilising such compounds.Type: GrantFiled: October 31, 2001Date of Patent: June 14, 2005Assignee: AstraZeneca ABInventors: Glen Ernst, Marc Chapdelaine, Dannielle Kissel, Greg Hostetler, John McCauley
-
Patent number: 6855341Abstract: Disclosed are anti-viral compositions containing at least one zinc compound and at least one phenolic antioxidant (and optionally other ingredients), and a pharmaceutical carrier. Also disclosed are methods of treating lesionous symptoms of a viral infection involving applying an effective amount of the anti-viral composition to the lesions.Type: GrantFiled: November 4, 2002Date of Patent: February 15, 2005Inventor: Jeffrey B. Smith
-
Patent number: 6800434Abstract: The present invention discloses novel peptide compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such peptides as well as methods of using them to treat disorders associated with the HCV protease.Type: GrantFiled: July 19, 2001Date of Patent: October 5, 2004Assignees: Schering Corporation, Dendreon CorporationInventors: Anil K. Saksena, Viyyoor Moopil Girijavallabhan, Raymond G. Lovey, Edwin Jao, Frank Bennett, Jinping L. McCormick, Haiyan Wang, Russell E. Pike, Stephane L. Bogen, Yi-Tsung Liu, Ashok Arasappan, Tejal Parekh, Patrick A. Pinto, F. George Njoroge, Ashit K. Ganguly, Terence K. Brunck, Scott Jeffrey Kemp, Odile Esther Levy, Marguerita Lim-Wilby
-
Patent number: 6783767Abstract: A powder composition which reacts in water to form in situ peroxycarboxylic acids at an anti-microbially effective concentration. Importantly, its utility is both for topical anti-microbial application and for effective low temperature disinfection/sterilization of instruments. It comprises the combination of a perborate, one or more novel acyl and/or aroyl donors, a buffering system which allows the pH to arise to about 9 for rapid formation of the peroxycarboxylic acids and then drop to about 7.5 for sustained stability and microbial kill. It preferably includes a surfactant facilitating antimicrobial efficacy, as well as other minors.Type: GrantFiled: February 8, 2002Date of Patent: August 31, 2004Assignee: Healthpoint, Ltd.Inventors: Braham Shroot, Lawton A. Seal, James R. Hunt, Jonathan Sterling, Kathy Bolsen, Penny L. Sitka
-
Publication number: 20040156873Abstract: The present invention relates to acne and rosacea compositions by a six-prong synergistic combination treatment strategy that includes (1) control of excess sebum production, (2) control of undesirable bacteria or mites, (3) control of inflammation, (4) enhanced desquamation of follicular infundibulum cells, (5) reduction of irritation from anti-acne or rosacea compositions themselves, and (6) enhancement of the topical bioavailability of anti-acne and rosacea compositions. This is achieved by a synergistic combination of commonly utilized topical anti-acne and rosacea ingredients with a topical bioavailability enhancement composition, which results in enhanced anti-acne and rosacea action from such ingredients. Moreover, additional inclusion of an anti-inflammatory composition, and also a vascular micro-circulation enhancement composition, further results in synergistic superior anti-acne and rosacea benefits from such compositions.Type: ApplicationFiled: February 10, 2003Publication date: August 12, 2004Inventor: SHYAM K. GUPTA
-
Patent number: 6730329Abstract: One aspect of the invention relates to anti-viral composition containing at least one zinc compound and at least one phenolic antioxidant (and optionally other ingredients such as at least one analgesic) at least one hydrocarbyl containing compound, and water. Another aspect of the invention relates to a method of treating lesionous symptoms of a viral infection involving applying an effective amount of the zinc containing anti-viral composition to the lesions.Type: GrantFiled: February 26, 2002Date of Patent: May 4, 2004Inventor: Jeffrey B. Smith
-
Patent number: 6727235Abstract: According to the invention, compositions are made available which have a strong cytotoxic effect which is largely selective on tumor tissue. The invention is based on the fact that certain benzoic acid derivatives have a strong synergistic effect as a mixture and destroy cancer cells selectively in a pH range of 7 or below, such as from 6.5 to 7.Type: GrantFiled: February 21, 2003Date of Patent: April 27, 2004Inventor: Werner Kreutz
-
Publication number: 20040022863Abstract: A composition and method of treating nappy rash utilizes a combination of Salicylic Acid (0.720/100 g), Boric Acid (5 g/100 g), Tannic Acid (0.575 g/100 g), Zinc oxide (5 g/100 g), Calamine (1.5 g/100 g), and Lanolin (2 g/100 g). Many oils have been also introduced including Olive oil (20.00 ml), Castor oil (10.00 ml), and Cod Liver oil (10.00 ml). Cetrimide is found as (0.0075 g/100 g) and White Petroleum Q.S.100 g.Type: ApplicationFiled: July 31, 2002Publication date: February 5, 2004Inventor: Samir I. Hamtini
-
Publication number: 20030202958Abstract: Dialysis solutions comprising aqueous solutions including physiologically acceptable salts and a polyglycol osmotic agent are disclosed. The subject solutions provide an improved osmotic gradient resulting in reduced dialysis times and/or reduced volumes of required dialysis solution. Moreover, the subject osmotic agents do not significantly migrate into the patient's blood over the time period of dialysis nor are the subject osmotic agents as susceptible to forming detrimental degradation products during gamma sterilization. The use of free radical scavengers is also described along with the use of a filter to reduce the introduction of bacteria into the peritoneal cavity.Type: ApplicationFiled: March 25, 2003Publication date: October 30, 2003Inventors: Alan D. Strickland, Jaime Simon
-
Patent number: 6525038Abstract: According to the invention, compositions are made available which have a strong cytotoxic effect which is largely selective on tumor tissue. The invention is based on the fact that certain benzoic acid derivatives have a strong synergistic effect as a mixture and destroy cancer cells selectively in a pH range of 7 or below, such as from 6.5 to 7.Type: GrantFiled: November 15, 2000Date of Patent: February 25, 2003Inventor: Werner Kreutz
-
Patent number: 6475526Abstract: One aspect of the invention relates to anti-viral composition containing at least one zinc compound and at least one phenolic antioxidant (and optionally other ingredients such as at least one analgesic) at least one hydrocarbyl containing compound, and water. Another aspect of the invention relates to a method of treating lesionous symptoms of a viral infection involving applying an effective amount of the zinc containing anti-viral composition to the lesions.Type: GrantFiled: June 5, 2001Date of Patent: November 5, 2002Inventor: Jeffrey B. Smith
-
Patent number: 6440406Abstract: The present invention provides a composition for attracting scarabs. Liquid and solid formulations are provided, along with methods for their use, for controlling or eliminating scarabs, and/or protecting plants susceptible to scarab damage.Type: GrantFiled: June 12, 2000Date of Patent: August 27, 2002Assignees: The United States of America as represented by the Secretary of Agriculture, The Texas A&M University SystemInventors: Juan D. Lopez, Jr., Robert L. Crocker, Ted N. Shaver
-
Publication number: 20020102314Abstract: The invention provides for astringent compositions comprising from about 0.1% to about 20% by weight of an astringent and between about 0.1% to 10% by weight of alcohol. The compositions have viscosity values of at least about 5,000 centipoise. The invention also provides for a method of using such compositions for delivering a topically active agent, such as salicylic acid, into skin.Type: ApplicationFiled: December 1, 2000Publication date: August 1, 2002Inventor: Geraldine A. Watson
-
Patent number: 6395720Abstract: According to the invention, compositions are made available which have a strong cytotoxic effect which is largely selective on tumor tissue. The invention is based on the fact that certain benzoic acid derivatives have a strong synergistic effect as a mixture and destroy cancer cells selectively in a pH range of 7 or below, such as from 6.5 to 7.Type: GrantFiled: March 27, 2000Date of Patent: May 28, 2002Inventor: Werner Kreutz
-
Publication number: 20010046979Abstract: Acidic antimicrobial compositions for treating food surfaces and food contact surfaces comprise an organic acid and a surfactant, said composition having a pH of from about 2 to about 5. Concentrated, acidic antimicrobial compositions preferably comprise a stabilizing agent to prevent precipitation of the surfactant upon dilution of the concentrated composition. Methods of use comprise contacting food surfaces or food contact surfaces with the compositions of the present invention. Articles of manufacture comprise a container, an acidic antimicrobial composition, and a set of instructions in association with the container.Type: ApplicationFiled: February 27, 2001Publication date: November 29, 2001Inventors: Brian Joseph Roselle, Fernando Ray Tollens, David Kent Rollins, Gregory Leo Jervier, Rodolfo Delgado
-
Publication number: 20010041694Abstract: Snake repellents include a repellent composition, an inert carrier and an adjuvant. The snake repellents include an essential oil selected from a group of essentials oils or a reagent from one of the essential oils. Methods of repelling snakes include exposing snakes to the snake repellents by aerosol, vapor or fog.Type: ApplicationFiled: December 26, 2000Publication date: November 15, 2001Inventors: Larry Clark, John A. Shivik
-
Patent number: 6306843Abstract: In a method for producing stable acetylsalicylic acid solutions with pharmaceutically acceptable non-aqueous organic solvents such as, e.g., dimethylisosorbide, propylene glycol or diethylene glycol monoethyl ether, 0.005-2% by weight of a cyclic acid imide and/or 0.005-2% by weight of a sulfaminic acid as well as, preferably, 1-40% by weight, based on the weight of the solution, of a compound of the general formula are added to the solution. In the general formula, R1 represents H, CH3 or C2H5, n=0 or 1, and R2 represents H or one or more lower alkyl, lower alkyloxy or lower alkenyl residues having 1 to 5 carbon atoms.Type: GrantFiled: January 13, 2000Date of Patent: October 23, 2001Inventors: Walter Burghart, Kurt Burghart
-
Patent number: 6232341Abstract: The present invention provides a topical pharmaceutical composition for wound healing, which comprises (a) borneol and (b) bismuth subgallate in effective amounts. The topical pharmaceutical composition is capable of enhancing wound healing with minor irritations to injured skin, and preventing formation of scars or granulation tissues so as to help regenerate the skin with normal tenderness and appearances.Type: GrantFiled: October 5, 1998Date of Patent: May 15, 2001Assignee: Hedonist Biochemical TechnologInventors: James J. T. Chen, Black J. B. Chen
-
Patent number: 6074634Abstract: The present invention provides an composition for attracting noctuid and/or other lepidopteran species. Liquid and solid formulations are provided, along with methods for their use, for controlling or eliminating noctuid and/or other lepidopteran species, and/or protecting plants susceptible to noctuid and/or other lepidopteran species damage.Type: GrantFiled: October 5, 1998Date of Patent: June 13, 2000Assignee: The United States of America as represented by the Secretary of AgricultureInventors: Juan D. Lopez, Jr., Ted N. Shaver, Kenneth R. Beerwinkle, Peter D. Lingren
-
Patent number: 5922785Abstract: Dental resins and dental compositions utilizing such resins are described. The dental compositions are particularly useful as cavity liners and root canal sealants which contain calcium hydroxide (or calcium oxide) and which are utilized to deliver calcium to exposed dental pulp. The resins, and resin-containing compounds, include eutectic mixtures of polyfunctional salicylates. In particular, the transesterification of a blend of trimethylolpropane and neopentylglycol with methyl salicylate yields a blend of trimethylolpropanetrisalicylate and neopentylglycoldisalicylate, which is contemplated by the present invention.Type: GrantFiled: August 11, 1997Date of Patent: July 13, 1999Assignee: The Kerr CorporationInventors: Duncan E. Waller, Emil Jandourek
-
Patent number: 5919776Abstract: The present invention is directed to aminoquinolines of Formula I: ##STR1## (wherein R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-1, CCR-2, CCR-2A, CCR-2B, CCR-3, CCR-4, CCR-5, CXCR-3, and/or CXCR-4.Type: GrantFiled: December 18, 1997Date of Patent: July 6, 1999Assignee: Merck & Co., Inc.Inventors: William K. Hagmann, Martin S. Springer
-
Patent number: 5885976Abstract: A composition is described which is useful for treating neurological and mental disorders which are associated with and/or related pathogenetically to deficient serotonin neurotransmission and impaired pineal melatonin functions in humans the composition being administered in combination with a sufficient amount of an AC pulsed magnetic field alone or in conjunction with a DC magnetic field and a sufficient amount of random noise to the brain of a human in need of such treatment which composition comprises an effective amount of a composition which increases serotonin transmission to the human to be treated.Type: GrantFiled: November 25, 1997Date of Patent: March 23, 1999Inventor: Reuven Sandyk
-
Patent number: 5830884Abstract: Thermally-inhibited starches and flours are used in pharmaceutical products as a diluent, filler, carrier, binder, disintegrant, coating, thickener, moisture sink, and the like. The starches and flours are inhibited by dehydrating the starch or flour to substantially anhydrous or anhydrous and then heat treating the anhydrous or substantially anhydrous starch or flour for a time and at a temperature sufficient to inhibit the starch or flour. The dehydration can be carried out by heating the starch or flour, by extracting the starch or flour with a solvent, or by freeze drying. Preferably, the pH is adjusted to a neutral pH or above prior to the dehydration and heat treatment.Type: GrantFiled: January 31, 1996Date of Patent: November 3, 1998Assignee: National Starch and Chemical Investment Holding CorporationInventors: James J. Kasica, David J. Thomas, James P. Zallie
-
Patent number: 5691324Abstract: A composition is described which is useful for treating neurological and mental disorders which are associated with and/or related pathogenetically to deficient serotonin neurotransmission and impaired pineal melatonin functions in humans the composition being administered in combination with a sufficient amount of an AC pulsed magnetic field alone or in combination with a sufficient amount of a DC magnetic field to the brain of a human in need of such treatment which composition comprises an effective amount of a composition which increases serotonin transmission to the human to be treated.Type: GrantFiled: May 8, 1995Date of Patent: November 25, 1997Inventor: Reuven Sandyk
-
Patent number: 5691325Abstract: A method of retarding the aging process and improving the symptoms of age-related disease conditions in humans which result from diminished pineal melatonin functions and reduced serotonin neurotransmission is described which comprises administering to a human in need thereof an effective amount of a composition which increases serotonin transmission to said human followed by the application to the brain of the human an effective amount of an AC pulsed magnetic field of proper intensity, frequency and waveform. Preferably the composition is supplemented by an effective amount of a dietary composition rich in the amino-acid tryptophan. Optionally an effective amount of an agent which provides growth hormone release is also administered prior to the application of the AC pulsed magnetic field.Type: GrantFiled: May 8, 1995Date of Patent: November 25, 1997Inventor: Reuven Sandyk
-
Patent number: 5650398Abstract: Disclosed herein are modified saponins or fractions thereof obtainable by modification of a crude Quillaja saponaria extract or by modification of purified saponins obtainable from a crude Quillaja saponaria extract useful in pharmaceutical compositions for enhancing the transport of pharmacologically active substances across mucous membranes of an animal. Also disclosed are modified saponins having reduced irritability wherein the aldehyde group is reduced and the fatty acid moiety may be removed by hydrolysis. Also disclosed are pharmaceutical compositions comprising the modified saponins of the invention.Type: GrantFiled: June 2, 1995Date of Patent: July 22, 1997Assignee: Cambridge Biotech CorporationInventors: Charlotte A. Kensil, Sean Soltysik, Dante J. Marciani, Joanne Recchia
-
Patent number: 5470846Abstract: A method of treating neurological and mental disorders which are associated with and/or related pathogenetically to deficient serotonin neurotransmission and impaired pineal melatonin functions in humans is described which comprises administering to a human in need thereof an effective amount of a composition which increases serotonin transmission to the patient to be treated followed by the application to the brain of the patient of a sufficient amount of an AC pulsed magnetic field of proper intensity and frequency to treat the disorder.Type: GrantFiled: January 14, 1994Date of Patent: November 28, 1995Inventor: Reuven Sandyk
-
Patent number: 5443829Abstract: Disclosed herein are modified saponins or fractions thereof obtainable by modification of a crude Quillaja saponaria extract or by modification of purified saponins obtainable from a crude Quillaja saponaria extract useful in pharmaceutical compositions for enhancing the transport of pharmacologically active substances across mucous membranes of an animal. Also disclosed are modified saponins having reduced irritability wherein the aldehyde group is reduced and the fatty acid moiety may be removed by hydrolysis. Also disclosed are pharmaceutical compositions comprising the modified saponins of the invention.Type: GrantFiled: September 24, 1993Date of Patent: August 22, 1995Assignee: Cambridge Biotech CorporationInventors: Charlotte A. Kensil, Sean Soltysik, Dante J. Marciani
-
Patent number: 5336271Abstract: A method for increasing the proportion of a crystalline organic compound which remains amorphous and suppressing recrystallization in which a crystalline organic compound and a hydrophilic polymer substance are fixed onto a surface of core particles by means of impacts applied in a high velocity gas stream. The solubility and stability of the resulting composite product, such as a drug for internal use, can be improved.Type: GrantFiled: March 20, 1992Date of Patent: August 9, 1994Assignee: Nara Machinery Co., Ltd.Inventors: Takafumi Ishizaka, Yuji Kikuchi, Masumi Koishi
-
Patent number: 5273965Abstract: Methods for enhancing the transport of pharmacologically active substances across mucous membranes of an animal by administration of pharmaceutical compositions comprising modified saponins or fractions thereof obtainable by modification of a crude Quillaja saponaria extract or by modification of purified saponins obtainable from a crude Quillaja saponaria extract. Also disclosed are modified saponins having reduced irritability wherein the fatty acid moiety is removed by hydrolysis or the aldehyde group is reduced. Also disclosed are pharmaceutical compositions comprising the modified saponins of the invention.Type: GrantFiled: July 2, 1992Date of Patent: December 28, 1993Assignee: Cambridge Biotech CorporationInventors: Charlotte A. Kensil, Sean Soltysik, Dante J. Marciani
-
Patent number: 5217965Abstract: The stability of compositions of choline salicylate-metal salicylate-carboxymethylcellulose is improved by the incorporation therein of microcrystalline cellulose. The microcrystalline cellulose is linked to the remainder of the composition by liquid bridges and is preferably present in an amount of about 2.5-25% by weight. The microcrystalline cellulose enhances the stability of the composition and thereby enhances solid dosage forms thereof such as tablets, capsules, suppositories and granules.Type: GrantFiled: June 17, 1991Date of Patent: June 8, 1993Assignee: Euroceltique, S.A.Inventors: Benjamin Oshlack, Frank C. Pedi, Jr., Joseph V. Zirlis
-
Patent number: 5108991Abstract: Compositions useful for carrying physiologically active agents such as therapeutic agents through skin and other body membranes comprising the agent and an effective, non-toxic amount of a compound having the structural formula ##STR1## wherein R' is H or a lower alkyl group, m is 3, N is 6-11 and R is --CH.sub.3.Type: GrantFiled: December 31, 1985Date of Patent: April 28, 1992Assignee: Whitby Research, Inc.Inventor: Vithal J. Rajadhyaksha
-
Patent number: 4783551Abstract: The invention is drawn to a compound of the formula ##STR1## which can be prepared by the reaction of acetylsalicylic acid with potassium carbonate or potassium bicarbonate in the presence of minor amounts of water. The compound is a substantially stable solid which readily dissolves in water with the formation of a neutral solution of an aspirin salt, i.e., potassium acetylsalicylate.Type: GrantFiled: May 20, 1986Date of Patent: November 8, 1988Inventor: Alexander Galat
-
Patent number: 4775667Abstract: Topical analgesic anti-inflammatory compositions containing a corticosteroid in addition to the conventional efficacy-proven ingredients are disclosed. They may be embodied in an aerosol, a solution and any other type of composition being convenient for administration. More than the sum of effects of the individual ingredients has been proved. In other words, the effects of the salicylate esters and L-menthol are synergistically enhanced by the addition of the corticosteroid. Particularly, the persistency of the analgesic/anti-inflammatory effects of the conventional ingredients has been proved to be dependent upon the the concentration of the corticosteroid in the composition.Type: GrantFiled: September 24, 1986Date of Patent: October 4, 1988Assignee: Shionogi & Co., Ltd.Inventors: Izumi Saitoh, Hirokuni Jyoyama, Fujio Asanuma, Katsumi Hirose, Shohei Egawa
-
Patent number: 4758555Abstract: Copper-dependent enzymes are required for normal brain development and function. Copper deficiency can result in pathological disorders accompanied by convulsive seizures or tremors in man and animals. The present invention is directed to a method for treating convulsions or epilepsy comprising administration of a therapeutically effective amount of an organic compound of copper having anticonvulsant activity. Those compounds include copper complexes of carboxylic acids, acylsalicylates, salicylates, amino acids, imines and known anticonvulsant and antiepileptic drugs.Type: GrantFiled: December 8, 1986Date of Patent: July 19, 1988Assignee: International Copper Research AssociationInventor: John R. J. Sorenson
-
Patent number: 4757060Abstract: A pharmaceutical composition and process for administering non-steroidal drugs which are protected against injury to the gastrointestinal tract by a combination of certain H.sub.1 and H.sub.2 receptor blockers.Type: GrantFiled: April 29, 1986Date of Patent: July 12, 1988Assignee: Bristol-Myers CompanyInventors: Alison B. Lukacsko, Randy J. Koslo, Joseph J. Piala
-
Patent number: 4591584Abstract: The present invention is concerned with compounds having a pharmaceutically acceptable degree of purity, and with formulations of these compounds for the treatment of inflammatory disorders in the intestine (IBD), especially ulcerative colitis. These compounds are 4,5'-azo-bis-salicylic acid (I) and its pharmaceutically acceptable salts, especially the disodium salt. The invention is also concerned with a method for treating inflammatory conditions in the intestine, especially ulcerative colitis. Finally the invention also comprises a method of producing 4,5'-azo-bis-salicylic acid with a pharmaceutically acceptable degree of purity.Type: GrantFiled: January 28, 1985Date of Patent: May 27, 1986Assignee: Pharmacia ABInventor: Karl H. Agback