Cosmetic Enhancement Or Care Patents (Class 514/18.8)
  • Patent number: 11058742
    Abstract: A peptide having an effect of suppressing hepatic lipogenesis, where a peptide is one or two or more peptides selected from 11 dipeptides (Ala-Gly, His-Asn, His-Ser, His-Thr, His-Trp, Val-Met, Trp-Glu, Trp-Lys, Tyr-Lys, Tyr-Ser and Tyr-Tyr) and 25 tripeptides (Val-Ile-Leu, Gly-Ser-Leu, Val-Leu-Gln, His-Ala-Gln, Arg-Ala-Val, Lys-Leu-Gly, Ile-Val-Ile, Lys-Pro-Ile, Leu- Val-Ile, Leu-Arg-Asp, Gln-Glu-Glu, Ser-Gly-Glu, Arg-Trp-Phe, Asp-Phe-Phe, Asp-Val-Phe, Pro-Phe-Tyr, Phe-Ile-Arg, Asn-Gly-Arg, Ile-Ile-Pro, Ile-Asp-Arg, Ile-His-Arg, Ile-Asp-Arg, Asn-Arg-Val, Ser-Ser-Val and Val-Phe-Val), is provided. The peptide may be used in a food composition for suppressing hepatic lipogenesis and an agent for suppressing hepatic lipogenesis.
    Type: Grant
    Filed: February 21, 2020
    Date of Patent: July 13, 2021
    Assignee: FUJI OIL HOLDINGS INC.
    Inventors: Hiroshi Inoue, Kumi Kimura, Nobuhiko Tachibana
  • Patent number: 10857206
    Abstract: A method of preventing or treating cutaneous pigmentation disease in a subject in need thereof, includes: providing a pharmaceutical composition comprising SDF1, an inducer or activator of SDF1, as an active ingredient; and administering the pharmaceutical composition to the subject, wherein the cutaneous pigmentation is prevented or treated, and the cutaneous pigmentation disease is selected from the group consisting of melasma, freckles, lentigo, nevus, pigmentation by drugs, pigmentation after inflammation and hyperpigmentation incurred from dermatitis.
    Type: Grant
    Filed: October 30, 2018
    Date of Patent: December 8, 2020
    Assignee: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
    Inventors: Hee Young Kang, Tae Jun Park, Jung Eun Yoon, Mi Sun Kim
  • Patent number: 10463628
    Abstract: The present invention is a composition comprising a plurality of nanoparticles of at least one noble metal each coated with a plurality of linker molecules, at least some of which are attached to at least one of a plurality of glycosaminoglycan chains.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: November 5, 2019
    Assignee: Lancaster University Business Enterprises LTD
    Inventor: Nigel James Fullwood
  • Patent number: 10376557
    Abstract: Short biologically active tetrapeptides are disclosed that are comprised of the sequences GxxG and PxxP where G (glycine) and P (proline) are maintained and x is a variable amino acid. The peptides can be used singly or in combination to stimulate production of extracellular matrix proteins in skin. A rapid, low-cost method of producing heterogenous formulations of tetrapeptides is disclosed.
    Type: Grant
    Filed: August 17, 2016
    Date of Patent: August 13, 2019
    Assignee: Helix Biomedix Inc.
    Inventors: Scott M. Harris, Timothy J. Falla, Lijuan Zhang
  • Patent number: 10359344
    Abstract: The present invention relates to a composition for clearing biotissue and a clarity method for biotissue using the same. The composition for clearing biotissue and the clarity method for biotissue using the same of the present invention do not need a high price electrophoresis apparatus and expensive solutions, and can not only be applied to various biotissues including brain, liver, lung, kidney, intestine, heart, muscle, and blood vessel, without damaging any of them but also prevent bubble formation, color change, and dark sediment; improve the clarity of biotissues; and help antibody-staining of the cleared tissues. Therefore, it is useful to identify the reason of various diseases through structural imaging of biotissue and to establish a treatment method.
    Type: Grant
    Filed: June 14, 2017
    Date of Patent: July 23, 2019
    Assignee: KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY
    Inventors: SunHyun Park, Ki-Suk Kim
  • Patent number: 10322189
    Abstract: A composition including an elastin-like polypeptide (ELP) coupled to a kidney targeting peptide and. a therapeutic agent is provided. A method of delivering a therapeutic agent to a subject in need thereof comprising: administering to the subject an effective amount of a composition comprising: an elastin-like polypeptide (ELP), a kidney targeting agent coupled to the ELP and a targeting agent and/or a drug binding domain coupled to the ELP, wherein the ELP includes an amino acid sequence having at least about repeats of the amino acid sequence GVPGX (SEQ ID NO: 1), and wherein the composition enhances the deposition and retention of the therapeutic agent in the kidney relative to the non-conjugated therapeutic.
    Type: Grant
    Filed: November 12, 2015
    Date of Patent: June 18, 2019
    Assignee: University of Mississippi Medical Center
    Inventors: Alejandro R. Chade, III, Gene L. Bidwell, III
  • Patent number: 9763869
    Abstract: A hydrophilic thickener comprising a polymer obtainable by subjecting a water-soluble ethylenically unsaturated monomer to a reversed phase suspension polymerization in the presence of a polyoxyethylene polyoxypropylene alkyl ether; and a cosmetic composition containing the hydrophilic thickener. The hydrophilic thickener according to the present invention can be used in the fields of cosmetics such as powder foundations, liquid foundations, emulsions, lotions, liquid cosmetics, moisturizing gel, all-in-one gels, cleansing foams, hair setting agents, emollient creams; toiletries, sundries, and the like.
    Type: Grant
    Filed: June 6, 2014
    Date of Patent: September 19, 2017
    Assignee: SUMITOMO SEIKA CHEMICALS CO., LTD.
    Inventors: Ayami Wajima, Junichi Mizukawa, Tsuyoshi Masuda, Hitoshi Ozawa
  • Patent number: 9616011
    Abstract: Personal care compositions comprising a dipeptide and methods of using such compositions to treat the condition of keratinous tissue. The C terminal amino acid of said dipeptide is threonine. The personal care composition can be applied topically, ingested orally, injected, or used as part of a combined treatment regimen.
    Type: Grant
    Filed: September 24, 2014
    Date of Patent: April 11, 2017
    Assignee: The Procter & Gamble Company
    Inventor: Rosemarie Osborne
  • Patent number: 9498424
    Abstract: An active mixture having (a) acylated oligopeptides, and (b) troxerutin, useful for increasing hair growth and in particular density of eyelashes and eyebrows.
    Type: Grant
    Filed: October 7, 2014
    Date of Patent: November 22, 2016
    Assignee: Symrise AG
    Inventors: Véronique Maurin, Cécile Kalem, Aurélie Trunet
  • Patent number: 9403041
    Abstract: The invention provides a cosmetic method for, preventing, minimizing and removing wrinkles and providing for smoother and more robust skin surfaces comprising applying a material incorporating water-insoluble copper compounds which release Cu+ ions, Cu++ ions or combinations thereof upon contact with a fluid to a body surface to be treated.
    Type: Grant
    Filed: November 9, 2005
    Date of Patent: August 2, 2016
    Assignee: Cupron Inc.
    Inventor: Jeffrey Gabbay
  • Patent number: 9255123
    Abstract: The invention addresses the problem of providing a skin-beautifying agent with beautifying effects such as skin moisturizing, skin beautification, prevention of rough skin, wrinkle prevention, prevention of reduced elasticity, etc., and a skin-beautifying product such as a cosmetic, food or drink, feed, medicine, etc. that contains said skin-beautifying agent. The skin-beautifying agent is characterized in containing a hydrolyzate of whey protein as an active ingredient. Using a whey protein hydrolyzate having the characteristics of a molecular weight distribution of 10 kDa or less, a main peak of 200 Da-3 kDa, APL (average peptide length) of 2-8, free amino acid content of 20% or less, and a ?-lactoglobulin antigenicity of 1/10,000 or less, in particular, provides a skin-beautifying agent of low allergenicity and low bitterness.
    Type: Grant
    Filed: March 7, 2012
    Date of Patent: February 9, 2016
    Assignee: MEGMILK SNOW BRAND CO., LTD.
    Inventors: Ken Katoh, Hiroshi Ueno, Yuko Ono, Noriko Ueda
  • Patent number: 9198846
    Abstract: Provided is a compound capable of gelling various aqueous compositions containing salt, acid and the like. A basic amino acid derivative represented by the formula (1): wherein each substituent is as defined in DESCRIPTION, or a salt thereof.
    Type: Grant
    Filed: August 6, 2014
    Date of Patent: December 1, 2015
    Assignee: AJINOMOTO CO., INC.
    Inventors: Kenji Hanabusa, Masahiro Suzuki, Takanori Sugimoto
  • Patent number: 9044444
    Abstract: A method for improving skin appearance and/or reducing hair loss in a subject is provided. The method comprises administrating to the subject an effective amount of peripheral monocytes, wherein the peripheral monocytes are induced by granulocyte colony stimulating factor (GCSF) or a combination of GCSF and an interleukin relative to GCSF.
    Type: Grant
    Filed: June 20, 2012
    Date of Patent: June 2, 2015
    Assignee: CHINA MEDICAL UNIVERSITY
    Inventors: Horng-Jyh Harn, Shinn-Zong Lin, Tzyy-Wen Chiou, Po-Cheng Lin, Hen-Yi Chu
  • Publication number: 20150148297
    Abstract: Disclosed is the a method of skin repair and firming, said method comprising the step of bringing into contact a pentapeptide conjugate of oleanolic acid with skin cells so that the effect of increased cellular communication at the molecular level to bring about gene and protein expression in the cells of the skin that enable repair and firming is realized. The invention demonstrates the effect of the pentapeptide conjugate of oleanolic acid in increasing Transforming Growth Factor-? and Fibroblast Growth Factor gene expressions in the skin.
    Type: Application
    Filed: February 5, 2015
    Publication date: May 28, 2015
    Inventors: Muhammed Majeed, Kalyanam Nagabhushanam
  • Patent number: 9040066
    Abstract: This invention is based upon the discovery that a mixture of ethyl lactate and isoamyl lactate can be used to improve the penetration of active ingredients in skin care formulations through the outer layers of the stratum corneum and viable epidermis and into the dermis layer of the skin structure. The present invention more specifically discloses a method of rejuvenating skin comprising topically applying a topical formulation to the skin, wherein the topical formulation is comprised of ascorbic acid, an amino acid selected from the group consisting of phenylalanine and tyrosine, a non-toxic zinc salt, carnosic acid, ?-tocopherol, 0.01 weight percent to 20 weight percent of a mixture of ethyl lactate and isoamyl lactate, wherein the weight ratio of the ethyl lactate to the isoamyl lactate is within the range of 1:10 to 20:1, and a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: April 7, 2014
    Date of Patent: May 26, 2015
    Assignee: Ad Lunam Labs, Inc.
    Inventors: William H. Beeson, Alvin T. Rockhill
  • Publication number: 20150140046
    Abstract: Compounds of general formula (I): R1-Wn-Xm-AA1-AA2-AA3-AA4-AA5-AA6-AA7-AA8-AA9-Yp-Zq-R2 (I) their stereoisomers, mixtures thereof and/or their cosmetically or pharmaceutically acceptable salts, preparation processes, cosmetic or pharmaceutical compositions which contain them and their use in medicine, particularly in the treatment and/or prevention of pain, inflammation, itching, neurological, compulsive and/or neuropsychiatric diseases and/or disorders and in processes of treatment and/or care of the skin, hair and/or mucous membranes mediated by neuronal exocytosis.
    Type: Application
    Filed: April 12, 2013
    Publication date: May 21, 2015
    Inventors: Antonio Vicente Ferrer Montiel, Gregorio Fernández Ballester, José María García Antón, Cristina Carreño Serraïma, Núria Almiñana Doménech, Raquel Delgado González
  • Patent number: 9034824
    Abstract: Potent compounds having combined antioxidant, anti-inflammatory, anti-radiation and metal chelating properties are described. Short peptides having these properties, and methods and uses of such short peptides in clinical and cosmetic applications are described.
    Type: Grant
    Filed: July 3, 2014
    Date of Patent: May 19, 2015
    Assignees: ONEDAY—BIOTECH AND PHARMA LTD., YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
    Inventors: Josef Mograbi, Daphne Atlas, Shoshana Keynan
  • Publication number: 20150132235
    Abstract: A cosmetic composition including as an active substance a cosmetically effective amount of at least one mu-conotoxin peptide It further concerns a composition wherein the mu-conotoxin peptide is Argninine, lysine polypeptide, CAS Number: 937286-43-6, Molecular formula C92, H139, N35, O28, S6 acetate salt (molar mass 2376 g/mol.). Also, the use of the composition to improve the mechanical properties of the skin, tonicity and/or firmness and/or elasticity of the skin.
    Type: Application
    Filed: April 15, 2013
    Publication date: May 14, 2015
    Applicant: ACTIVEN
    Inventors: Reto Stocklin, Jean-Marc Le Doussal, Louis Lamy, Bethsabee Coutaz
  • Patent number: 9029329
    Abstract: The invention relates to peptidic compounds of general formula (I) R1-(AA)n-X1-X2-Ile-Gln-Ala-Cys-Arg-Gly-X3-(AA)p-R2 as caspase-14 activators. The invention also relates to a cosmetic or pharmaceutical composition comprising at least one peptide of general formula (I), in a physiologically acceptable medium, and to the use of said composition for preventing and/or repairing damage to deoxyribonucleic acid, for preventing and/or treating cutaneous signs of ageing and photo-ageing, and for improving the skin barrier function. The invention further relates to a cosmetic treatment method for preventing and/or treating cutaneous signs of ageing and photo-ageing, and for preventing and/or repairing damage caused by ultraviolet radiation.
    Type: Grant
    Filed: February 1, 2011
    Date of Patent: May 12, 2015
    Assignee: ISP Investments Inc.
    Inventors: Claude Dal Farra, Nouha Domloge, Jean-Marie Botto
  • Publication number: 20150125410
    Abstract: A hyaluronic acid production promoter and a melanin synthesis inhibitor include soybean saponin as an active ingredient. The soybean saponin can be a soybean saponin aglycone, such as soyasapogenol A and/or soyasapogenol B. The hyaluronic acid production promoter and melanin synthesis inhibitor can be administered transdermally or orally.
    Type: Application
    Filed: January 9, 2015
    Publication date: May 7, 2015
    Inventors: Shuichi KAMO, Shunsuke SUZUKI, Toshiro SATO
  • Patent number: 9023801
    Abstract: A topical composition for application to aging skin, including an effective amount of S-acyl glutathione derivative of formula (I) wherein R1 consists of an unsaturated or saturated C16 acyl group and R2 is a hydrogen, aliphatic or aromatic acyl group; and a dermatologically acceptable carrier. Preferred compositions include about 1.0% to about 3.0% by weight of S-palmitoyl glutathione.
    Type: Grant
    Filed: October 23, 2013
    Date of Patent: May 5, 2015
    Assignee: N.V. Perricone LLC
    Inventor: Nicholas V. Perricone
  • Publication number: 20150104485
    Abstract: Compounds of general formula (I): Ri—Wn—Xm-AAi-AA2-AA3-AA4-AA5-AA6-Yp—Zq—R2 (I) their stereoisomers, mixtures thereof and/or their cosmetically or pharmaceutically acceptable salts, preparation processes, cosmetic and/or pharmaceutical compositions which contain them and their use in medicine, particularly in the treatment and/or prevention of pain, inflammation, itching, pigmentation disorders and angiogenic skin disorders, and in processes of treatment and/or care of the skin and/or mucous membranes.
    Type: Application
    Filed: April 16, 2013
    Publication date: April 16, 2015
    Applicant: LUBRIZOL ADVANCED MATERIALS, INC.
    Inventors: Jose Maria Garcia Anton, Antonio Vicente Ferrer Montiel, Cristina Carreño Serraïma, Raquel Delgado González, Juan Cebrián Puche
  • Publication number: 20150105325
    Abstract: Disclosed are pharmaceutical and synergistic compositions comprising human recombination alpha-fetoprotein expressed in eukaryotic cells for preparation of therapeutic agents for use in oncology, immunotherapy, stem cell therapy and cosmetology and also for the diagnosis of cancer and embryonic pathologies.
    Type: Application
    Filed: December 5, 2014
    Publication date: April 16, 2015
    Inventors: Igor Dudich, Lydia Semenkova, Igor Dudich, Eduard Tatulov
  • Publication number: 20150098989
    Abstract: Compounds of general formula (I): R1—Wn—Xm-AA1-AA2-AA3-AA4-AA5-AA6-AA7-Yp—Zq—R2, their stereoisomers, mixtures thereof and/or their cosmetically or pharmaceutically acceptable salts, preparation processes, cosmetic or pharmaceutical compositions which contain them and their use in medicine, particularly in the treatment and/or prevention of pain, inflammation, itching, neurological, compulsive and/or neuropsychiatric diseases and/or disorders and in processes of treatment and/or care of the skin, hair and/or mucous membranes mediated by neuronal exocytosis.
    Type: Application
    Filed: April 12, 2013
    Publication date: April 9, 2015
    Inventors: Antonio Vicente Ferrer Montiel, Gregorio Fernández Ballester, José María García Antón, Cristina Carreño Serraïma, Núria Almiñana Doménech, Raquel Delgado González
  • Publication number: 20150098973
    Abstract: Provided in various embodiments are compositions for topical application to the skin, comprising a silsesquioxane resin wax, at least one solid particulate with an average particle size greater than 1 micron, and one or more additional waxes.
    Type: Application
    Filed: April 29, 2013
    Publication date: April 9, 2015
    Inventors: Gerald Brissette, Lok Ming Eva Li, Yihan Liu, Mary Kay Tomalia, Adrianna Urrutia-Gutierrez
  • Publication number: 20150094270
    Abstract: Short biologically active tetrapeptides are disclosed that are comprised of the sequences GxxG and PxxP where G (glycine) and P (proline) are maintained and x is a variable amino acid. The peptides can be used singly or in combination to stimulate production of extracellular matrix proteins in skin. A rapid, low-cost method of producing heterogenous formulations of tetrapeptides is disclosed.
    Type: Application
    Filed: November 3, 2014
    Publication date: April 2, 2015
    Applicant: HELIX BIOMEDIX, INC.
    Inventors: Scott M. Harris, Timothy J. Falla, Lijuan Zhang
  • Publication number: 20150093346
    Abstract: Disclosed is a method of firming skin or reducing the appearance of fine lines or wrinkles comprising topically applying, to skin in need thereof, a composition comprising palmitoyl tetrapeptide 7 and a dermatologically acceptable vehicle comprising water, glycerin, butylene glycol, propylene glycol, and a chelating agent, wherein topical application of the composition to the skin firms the skin or reduces the appearance of fine lines or wrinkles, and wherein the composition is not a sunless tanning composition.
    Type: Application
    Filed: September 10, 2014
    Publication date: April 2, 2015
    Inventors: Dawn Burke-Colvin, Michelle Hines, David Gan
  • Publication number: 20150094269
    Abstract: A composition is disclosed that includes pure silk fibroin-based protein fragments that are substantially devoid of sericin, wherein the composition has an average weight average molecular weight ranging from about 17 kDa to about 38 kDa, wherein the composition has a polydispersity of between about 1.5 and about 3.0, wherein the composition is substantially homogeneous, wherein the composition between 0 ppm to about 500 ppm of inorganic residuals, and wherein the composition includes between 0 ppm to about 500 ppm of organic residuals.
    Type: Application
    Filed: September 30, 2014
    Publication date: April 2, 2015
    Inventors: Gregory H. Altman, Rebecca L. Horan, Rachel Lee Dow, Rachel M. Lind, Dylan S. Haas
  • Publication number: 20150087597
    Abstract: Described herein are fragments of fibronectin and vitronectin and variants thereof that have certain activities, including growth factor-binding activity. Also described are fragments of growth factors that bind to fibronectin and inhibit binding of full-length growth factors to fibronectin. Compositions containing such fragments are useful in cosmetic treatments (e.g., the treatment of wrinkles or UV photodamage of skin), and the treatment of wounds and cancer.
    Type: Application
    Filed: May 1, 2014
    Publication date: March 26, 2015
    Applicant: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventor: Richard A. Clark
  • Publication number: 20150071856
    Abstract: The invention is in the field of molecular medicine. It provides antagonistic compounds for frizzled-1 and/or frizzled-2 receptors, which may be useful in molecular imaging of the wound healing process after myocardial infarction and in therapeutic intervention into wound healing after remodeling of the heart, thereby ameliorating the consequences of myocardial infarction. The invention provides a method for antagonizing frizzled-1 or frizzled-2 receptors, wherein the receptor is contacted with a composition comprising a linear fragment of Wnt3(a) or Wnt5a or a functional analogue thereof, which comprises at least one cysteine residue, one threonine residue, one aspartic acid residue and one glycine residue.
    Type: Application
    Filed: September 12, 2013
    Publication date: March 12, 2015
    Inventors: Wessel Matthijs Blankesteijn, Hilde Laeremans, Tilman Mathias Hackeng
  • Publication number: 20150064121
    Abstract: A cosmetic composition having a synergistic TRF2 protein activation system consisting essentially of a combination of a peptidic soybean and yeast extract in a physiologically acceptable medium is disclosed and protecting or treating damage to the DNA of skin cells associated with aging by applying the cosmetic composition thereto, typically topically. The peptidic soybean and yeast extract is obtained by hydrolyzing at least 80% of soybeans by weight of the total weight of raw materials and at most 20% of yeast by weight of the total weight of raw materials.
    Type: Application
    Filed: March 8, 2013
    Publication date: March 5, 2015
    Applicant: ISP Investments Inc.
    Inventors: Jean-Marie Botto, Nouha Domloge, Frederique Portolan
  • Patent number: 8962565
    Abstract: Peptide compounds of general formula (I) R1-(AA)n-X1—X2—X3-Asp-Leu-Lys-Lys-X4—X5-(AA)p-R2, cosmetic or pharmaceutical compositions comprising at least one peptide compound of general formula (I) in a physiologically acceptable medium, and methods for cosmetic treatment of skin are disclosed. The peptide compounds of general formula (I) were demonstrated to be agents making it possible to influence the pigmentation of the skin and skin appendages, by ensuring optimal transfer of the melanosomes to the keratinocytes, so as to make the skin tone uniform owing to an effect on the SCF/c-Kit signaling pathway. The compounds, compositions, and methods treat or attenuate age-related pigmentation defects and the effects of photoaging on the skin.
    Type: Grant
    Filed: January 30, 2012
    Date of Patent: February 24, 2015
    Assignee: ISP Investments Inc.
    Inventors: Claude Dal Farra, Nouha Domloge, Jean-Marie Botto
  • Publication number: 20150038428
    Abstract: The present invention relates to organogels and emulsions based on ultrasmall self-assembling peptides. It further relates to methods for producing such organogels and emulsions as well as to the use of the organogels and emulsions in biological and non-biological applications.
    Type: Application
    Filed: February 22, 2013
    Publication date: February 5, 2015
    Inventors: Charlotte Hauser, Archana Mishra
  • Patent number: 8946166
    Abstract: Peptides of general formula (I): R1-Wn-Xm-AA1-AA2-AA3-AA4-AA5-AA6-Yp-Zs-R2 their stereoisomers, mixtures thereof and/or their cosmetically or pharmaceutically acceptable salts, their preparation process, cosmetic or pharmaceutical compositions which contain them and their use in the treatment and/or care of conditions, disorders and/or diseases that are a consequence of muscle contraction.
    Type: Grant
    Filed: July 23, 2010
    Date of Patent: February 3, 2015
    Assignee: Lipotec, S.A.
    Inventors: Nuria Garcia Sanz, Wim Van Den Nest, Cristina Carreno Serraima, Antonio Ferrer Montiel, Juan Cebrian Puche, Nuria Alminana Domenech, Gregorio Fernandez Ballester
  • Patent number: 8933036
    Abstract: A method of attenuating hair loss includes applying to the hair a composition having an effective amount of a hair-loss attenuating peptide hydrolysate and a cosmetically acceptable carrier.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: January 13, 2015
    Assignee: ISP Investments Inc.
    Inventors: Claude Dal Farra, Nouha Domloge, Jean-Marie Botto, Catherine Gondran, Corinne Coquet, Frederique Portolan
  • Patent number: 8932650
    Abstract: A two-part aqueous composition for treating skin ailments, such as acne vulgaris, includes an acidic part having salicylic acid and an ?-hydroxy acid, and an alkaline part having an alkaline nitrite salt. The ?-hydroxy acid is preferably glycolic acid, lactic acid, malic acid, mandelic acid or a combination thereof. The alkaline nitrite salt is preferably sodium nitrite. The acidic part and the alkaline part are an acidic aqueous solution and an alkaline aqueous solution, respectively, which may either be mixed with one another then applied to an affected portion of a patient's skin or, alternatively, may be sequentially applied to the affected portion of the patient's skin, preferably within 15 minutes of one another.
    Type: Grant
    Filed: February 8, 2013
    Date of Patent: January 13, 2015
    Assignee: Kantian Skincare LLC
    Inventor: Robert D. Kross
  • Patent number: 8927499
    Abstract: The invention provides a method for inhibiting melanin formation composition by applying a glycine derivative, having a structure shown in the following general equation (I): wherein R1 represents a C1˜C4 alkyl group; R2 represents a hydrogen atom or a methyl group; and n represents an integer of 1˜6.
    Type: Grant
    Filed: January 21, 2014
    Date of Patent: January 6, 2015
    Assignee: Corum Inc.
    Inventors: Nai-Hsuan Hsu, Chiao-Yi Hsu, Ssu-Ching Wang, Ting-Wan Chen, Chu-Yi Pang
  • Patent number: 8906425
    Abstract: The invention relates to the stimulation of the synthesis and of the activity of an isoform of lysyl oxidase, and more particularly of the LOXL (lysyl oxidase-like) isoform. The invention relates notably to a method of identifying an active principle which stimulates the formation of elastic fibers. The aim of the invention is mainly to provide such a method of identification so as to provide compositions which enable stimulating the formation of elastic fibers.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: December 9, 2014
    Assignees: BASF Beauty Care Solutions France S.A.S., Centre National de la Recherche Scientifique
    Inventors: Eric Perrier, Valérie Cenizo, Charbel Bouez, Pascal Sommer, Odile Damour, Claudine Gleyzal, Valérie Andre, Corinne Reymermier
  • Patent number: 8901080
    Abstract: This invention discloses a new conjugate compound that comprises at least one HA oligomer derivatized through one thiolated linker, whereby it binds to at least one metal nanoparticle, such as, for example, a gold nanoparticle. Moreover, it discloses methods of obtaining it, as well as the use thereof in a cosmetic treatment, and cosmetic compositions that contain them.
    Type: Grant
    Filed: January 5, 2009
    Date of Patent: December 2, 2014
    Assignee: Endor Nanotechnologies, S.L.
    Inventors: Marc Ramis Castelltort, Isaac Ojea Jimenez, Joaquin Querol Sastre
  • Patent number: 8883725
    Abstract: The present invention relates to compositions and methods useful in studying or modulating melanin pigmentation in the skin. Particularly, the invention relates to compositions comprising a substance capable of modulating the activity or expression of ALK6 (SEQ ID 2) or Cdc42 which in turn are capable of modulation of the transfer of melanin from melanocytes to keratinocytes and potentially from keratinocytes to keratinocytes. The invention also relates to assays for identifying such compositions, and methods of modulating skin pigmentation.
    Type: Grant
    Filed: September 8, 2009
    Date of Patent: November 11, 2014
    Assignee: University of Bradford
    Inventors: Suman Kumar Singh, Desmond John Tobin
  • Patent number: 8883734
    Abstract: The present invention relates to peptidic compounds of general formula (I): R1—X1-Arg-Lys-Gly-X2—R2. In addition, the present invention relates to, on the one hand, a cosmetic or pharmaceutical composition comprising at least one peptide of general formula (I), in a cosmetically or pharmaceutically acceptable medium and, on the other hand, its utilization to prevent or treat the cutaneous signs of aging and photo-aging and to protect the skin from aggressions due to UV radiation. Lastly, the invention applies to a cosmetic treatment process intended to prevent and/or combat the cutaneous signs of aging and photo aging.
    Type: Grant
    Filed: April 1, 2010
    Date of Patent: November 11, 2014
    Assignee: ISP Investments Inc.
    Inventors: Claude Dal Farra, Nouha Domloge, Jean-Marie Botto
  • Publication number: 20140328782
    Abstract: The present invention relates to a peptide inhibiting a matrix metalloproteanases activity and use thereof. The peptide inhibiting a matrix metalloproteanases activity exhibits an excellent efficacy of improving the condition of skin by directly inhibiting the matrix metalloproteanases activity. In addition, a composition containing the peptide of the invention has excellent bioactivities of inhibiting the activity of hyaluronic acid degrading enzymes, adipogenesis in fat cells, angiogenesis, and the like, thereby being useful for the treatment of various disease such as anti-obesity, anti-cancer, anti-inflammation, and the like, and skin permeability is excellent due to the small size of the peptide, thereby being useful in various fields. The peptide of the invention having excellent activity and safety can be advantageously applied to drugs, quasi-drugs, and cosmetics.
    Type: Application
    Filed: November 2, 2011
    Publication date: November 6, 2014
    Applicant: CAREGEN CO., LTD.
    Inventors: Young Ji Chung, Eun Mi Kim
  • Patent number: 8877713
    Abstract: Methods of restoring the circadian rhythm and resynchronizing the biological clock of cells are described. The methods include topically applying a topical composition comprising a cosmetically acceptable medium and an effective quantity of a peptide compound of general formula (I), R1-(AA)n-X1-Ser-Thr-Pro-X2-(AA)p-R2, to skin or skin appendages to be treated.
    Type: Grant
    Filed: July 5, 2013
    Date of Patent: November 4, 2014
    Assignee: ISP Investments
    Inventors: Claude Dal Farra, Nouha Domloge, Jean-Marie Botto
  • Publication number: 20140322307
    Abstract: The present invention refers to a peptide of general formula (I) R1-Wn-Xm-AA1-AA2-AA3-AA4-AA5-AA6-Yp-Zq-R2, cosmetic compositions which comprises said peptide, method of preparation of said peptides and its use in the treatment and/or prevention of itching, inflammation, pain, diseases and/or disorders of the respiratory airways.
    Type: Application
    Filed: October 31, 2012
    Publication date: October 30, 2014
    Inventors: Antonio Vicente Ferrer Montiel, José María García Antón, Raquel Delgado González
  • Patent number: 8871717
    Abstract: Personal care compositions comprising a dipeptide and methods of using such compositions to treat the condition of keratinous tissue. The C terminal amino acid of said dipeptide is threonine. The personal care composition can be applied topically, ingested orally, injected, or used as part of a combined treatment regimen.
    Type: Grant
    Filed: April 7, 2011
    Date of Patent: October 28, 2014
    Assignee: The Procter & Gamble Company
    Inventor: Rosemarie Osborne
  • Publication number: 20140315787
    Abstract: Potent compounds having combined antioxidant, anti-inflammatory, anti-radiation and metal chelating properties are described. Short peptides having these properties, and methods and uses of such short peptides in clinical and cosmetic applications are described.
    Type: Application
    Filed: July 3, 2014
    Publication date: October 23, 2014
    Inventors: Josef Mograbi, Daphne Atlas, Shoshana Keynan
  • Patent number: 8865651
    Abstract: The invention is directed to an anti ageing skin care composition, more in particular a cosmetic anti aging skin care composition. The anti ageing skin care composition of the invention comprise, in a physiologically acceptable medium, (i) at least one peptide from Laminin-1 that is able to promote synthesis of Laminin-5; (ii) at least one peptide capable of at least partially inhibiting neuronal exocytosis; and (iii) at least one tripeptide producing a rapid and strong stimulation of collagen synthesis. The compositions of the present invention are effective in reducing existing wrinkles and/or preventing the formation of new wrinkles.
    Type: Grant
    Filed: May 8, 2008
    Date of Patent: October 21, 2014
    Assignee: Tupperware Products S.A.
    Inventors: Stephanus Cornelis Maria Otte, Claudia Amalia Estrada Hernández, Annis Won
  • Publication number: 20140309173
    Abstract: The invention provides compositions for stimulating the formation of one or more extracellular matrix components that contain a lipoaminoacid derivative of the tripeptide carnosine such as N-Octanoyl Carnosine. Also provided are compositions containing N-Octanoyl Carnosine in combination with selected tripeptide and/or tetrapeptides as well as pharmaceutical and/or cosmetic compositions containing such compositions. The invention further provides methods of using the compositions and compositions of the invention to treat, alleviate, and/or ameliorate a symptom, condition, disorder, or disease of the skin or mucosa, wherein the symptom, condition, disorder, or disease is associated with changes in extracellular matrix components.
    Type: Application
    Filed: March 10, 2014
    Publication date: October 16, 2014
    Inventor: Frank Dreher
  • Publication number: 20140309157
    Abstract: The present invention relates to a WNT-derived novel peptide and use thereof. WNT-derived peptide of the present invention possesses identical or similar activities to natural-occurring WNT protein, and has much higher stability and skin penetration potency than natural-occurring WNT protein. Therefore, the composition containing the present peptide not only shows excellent effects on improvement in hair loss (for example, promotion of hair growth or production of hair), but also has superior efficacies on treatment of a WNT signal transduction pathway-related disorder. In addition, the outstanding activity and stability of the present peptide described above may be greatly advantageous in application to pharmaceutical compositions, quasi-drugs and cosmetics.
    Type: Application
    Filed: May 9, 2012
    Publication date: October 16, 2014
    Applicant: CAREGEN CO., LTD.
    Inventors: Yong Ji Chung, Eun Mi Kim
  • Publication number: 20140303080
    Abstract: N-acyldipeptide derivatives are described. Compositions comprising the N-acyldipeptide derivatives are therapeutically effective for topical or systemic administration to alleviate or improve conditions, disorders, diseases, symptoms or syndromes associated with a tumor, cancer, immune, nervous, vascular, musculoskeletal or cutaneous system, or other tissue or system in a subject.
    Type: Application
    Filed: October 31, 2012
    Publication date: October 9, 2014
    Inventors: Ruey J. Yu, Eugene J. Van Scott