Patent number: 6569846
Abstract: Palladium-substituted Bacteriochlorophyll derivatives of formula (I), wherein A represents OH, OR1, —O—(CH2)n—Y, —S—(CH2)n—Y, —NH—(CH2)n—Y, —O—(CH2)2—NH2, —O—(CH2)2—OH, —NH—(CH2)n—+N o, X—, —NH0(CH2)2—NH═BOC or —N—(CH2—CH═CH2)2; wherein R1 represents Na+, K+, (Ca2+)0, 5, (Mg2+)0, 5, Li+, NH4+, NH3—C(CH2OH)3 +NH3—CH2—(CHOH)4—CH2OH, +NH2(CH3)—CH2—(CHOH)4—CH2OH or +N(CN′H2n′+1)4; R2 represents H, OH or COOR4, wherein R4 is C1-C12 alkyl or C3-C12 cycloalkl; R3 represents H, OH or C1-C12 alkyl or alkoxy; n is 1, 2, 3, 4, 5 or 6, Y is —NR′1R′2R′3, X-wherein R′1, R′2 and R′3 independently from each other represent —CH3 or —C2H5; X is F, Cl, Br or 1, n′ is 1, 2, 3 or 4 and their oxidized forms, are u
Type:
Grant
Filed:
September 18, 2001
Date of Patent:
May 27, 2003
Assignee:
Yeda Research and Development Co. Ltd.
Inventors:
Avigdor Scherz, Yoram Salomon, Alexander Brandis, Hugo Scheer
Patent number: 6562806
Abstract: A compound with formula (I)
where R10 is a therapeutically removable nitrogen protecting group; R2 and R3 are independently selected from: H, R, OH, OR, ═O, ═CH—R, ═CH2, CH2—CO2R, CH2—CO2H, CH2—SO2R, O—SO2—R, CO2R, COR and CN; R6, R7 and R9 are independently selected from H, R, OH, OR, halo, amino, nitro, Me3Sn; X is S, O or NH; R11 is either H or R; and where there is optionally a double bond between C1 and C2 or C2 and C3; and R8 is selected from H, R, OH, OR, halo, amino, nitro, Me3Sn, or R7 and R8 together form a group —O—(CH2)p—O—, where p is 1 or 2. Such compounds may be used in methods of ADEPT, GDEPT, NPEPT or PDT.
Type:
Grant
Filed:
February 26, 2001
Date of Patent:
May 13, 2003
Assignee:
Spirogen Limited
Inventors:
David Edwin Thurston, Philip Wilson Howard
Patent number: 6525041
Abstract: Low molecular weight mimics of superoxide dismutase (SOD) represented by the formula:
wherein R, R′, R1, R′1, R2, R′2, R3, R′3, R4, R′4, R5, R′5, R6, R′6, R7, R′7, R8, R′8, R9, and R′9, M, X, Y, Z and n are as defined herein, useful as therapeutic agents for inflammatory disease states and disorders, ischemic/reperfusion injury, stroke, atherosclerosis, and all other conditions of oxidant-induced tissue damage or injury.
Type:
Grant
Filed:
March 14, 1996
Date of Patent:
February 25, 2003
Assignee:
Pharmacia Corporation
Inventors:
William L. Neumann, Dennis P. Riley, Randy H. Weiss, Susan L. Henke, Patrick J. Lennon, Karl W. Aston