Hetero Ring Is Six-membered Consisting Of One Nitrogen And Five Carbons Patents (Class 514/188)
  • Patent number: 11766415
    Abstract: The invention relates generally to the field of medical treatment. More particularly, the invention relates to treating a subject in order to reduce levels of triglycerides or cortisol by the administration of pharmaceutical formulations.
    Type: Grant
    Filed: May 25, 2021
    Date of Patent: September 26, 2023
    Inventor: Daniel E. Clouatre
  • Patent number: 11344556
    Abstract: In various embodiments an appetite suppressant composition comprises at least one anorectic active ingredient (AAI); at least one of a nutritive substance, a controlled drug delivery agent (CDRA), and a cofactor; and optionally, an excipient. The AIA may comprise any one of phentermine, phendimetrazine, diethylpropion, naltrexone, and bupropion. The CDRA may comprise a cellulosic. The cofactor may comprise a chromium or selenium salt. In various embodiments, the compositions herein are provided in an oral capsule dosage form for GI-tract administration of the AAI. A method of suppressing appetite in individuals in need thereof are described.
    Type: Grant
    Filed: March 3, 2020
    Date of Patent: May 31, 2022
    Inventor: Suzanne Bentz
  • Patent number: 11065274
    Abstract: The present invention features a composition comprising zinc pyrithione and silver sulfiadizine, a formulation thereof and a method of treating microbial infection using the composition.
    Type: Grant
    Filed: July 26, 2016
    Date of Patent: July 20, 2021
    Assignee: University of Rochester
    Inventor: Paul M. Dunman
  • Patent number: 11065259
    Abstract: A method of treating pruritus (itching) in a subject in need thereof is carried out by administering the subject an active agent in a treatment effective amount, wherein the active agent is a superoxide dismuate (SOD) mimetic. The SOD mimetic can be a complex of a metal (e.g., manganese) and an organic ligand, with suitable organic ligands including porphyrins, polyamines, salens, nitroxides, and fullerenes. Compositions for carrying out such methods are also described.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: July 20, 2021
    Assignees: Duke University, BioMimetix JV, LLC
    Inventors: Ru-Rong Ji, Tong Liu, Ines Batinic-Haberle, David S. Warner, Kimberly C. Stone, James D. Crapo
  • Patent number: 10987340
    Abstract: A composition and method for rapidly inducing a state of endogenous ketosis, the composition including: about 26.66-28.57 percent by mass of alpha lipoic acid; about 0.01-0.02 percent by mass of chromium picolinate; about 47.61-49.99 percent by mass of L-arginine; and, about 23.33-23.81 percent by mass of calcium carbonate. The method includes restricting carbohydrate consumption to a maximum dosage of about 20 grams prior to consumption of the composition and wherein consumption of the composition is on an empty stomach. About thirty minutes after consumption of the composition the user performs moderate intensity exercise. About three hours after consuming a first dose the user tests for a presence of ketones in urine utilizing at least one sodium nitroprusside urine ketone reagent strip.
    Type: Grant
    Filed: July 7, 2016
    Date of Patent: April 27, 2021
    Inventor: Jesse Alexander Galinski
  • Patent number: 10563059
    Abstract: The present invention relates to a composition comprising a stable aqueous dispersion of polymer particles comprising structural units of a polymerizable amino acid and structural units of an acid monomer or a salt thereof. The composition of the present invention is useful in improving lipstick stain resistance in coatings compositions.
    Type: Grant
    Filed: December 13, 2017
    Date of Patent: February 18, 2020
    Assignee: Rohm and Haas Company
    Inventors: James C. Bohling, Arnold S. Brownell, Muhunthan Sathiosatham
  • Patent number: 10543157
    Abstract: The present invention is directed to a method for treating a hair disorder in a human or animal in need thereof, involving topically applying to the human or animal an effective amount of at least one 6-substituted 2-pyridinol N-oxide compound, a tautomer, or a cosmetically acceptable salt thereof wherein a hair count is increased by at least 0.5 hairs/cm2 and/or an increase the number of anagen hairs and maintain the number of telogen hairs when compared to a baseline and/or vehicle.
    Type: Grant
    Filed: April 28, 2017
    Date of Patent: January 28, 2020
    Assignee: The Procter and Gamble Company
    Inventors: Michael Glenn Davis, Robert Scott Youngquist
  • Patent number: 10369127
    Abstract: A method for inhibiting the expression and/or functional activity of an ABC transporter protein in a subject suffering from a disorder associated with an overexpression of the ABC transporter protein includes administrating a cobalt-polypyridyl complex to the subject. A method for inhibiting the expression and/or functional activity of an ABC transporter in cells includes contacting the cells with an effective amount of the cobalt-polypyridyl complex.
    Type: Grant
    Filed: June 26, 2017
    Date of Patent: August 6, 2019
    Inventors: Kam Wai Wong, Yuen Kwan Law, Man Chung Wong
  • Patent number: 10111893
    Abstract: Methods for treatment of a pathological condition caused by oxidative stress in a patient comprise administering to the patient a mixed metal complex of a compound of Formula I, or a salt thereof, in an amount effective to reduce the oxidative stress. Pharmaceutical compositions are formed by suspending or dissolving a mixed metal complex of a compound of Formula I, or a salt thereof, in a liquid medium, optionally with one or more physiologically acceptable excipients. The mixed metals comprise calcium and manganese in a molar ratio of calcium to manganese in the range of 1-10: wherein X, R1, R2, R3, and R4 are as defined herein.
    Type: Grant
    Filed: February 28, 2017
    Date of Patent: October 30, 2018
    Assignee: PLEDPHARMA AB
    Inventors: Jan-Olof Karlsson, Karl Reineke, Tino Kurz, Rolf Andersson, Michael Hall, Christina McLaughlin, Sven Jacobsson, Jacques Näsström
  • Patent number: 9895338
    Abstract: A method for treating a subject suffering from a cancer, in particular a multidrug-resistant cancer includes administrating a cobalt-polypyridyl complex to the subject. A method for suppressing the growth of cancer cells, in particular inducing autophagy of the cancer cells, inducing cell cycle arrest of the cancer cells and/or inhibiting cell invasion of the cancer cells and for specifically targeting cancer cells with multidrug-resistance includes contacting said cancer cells with the cobalt-polypyridyl complex. A pharmaceutical composition and a kit are provided and include the cobalt-polypyridyl complex. Unexpectedly, the cobalt-polypyridyl complex is especially suitable to treat cancer, in particular multidrug-resistant cancer with an exceptionally increased cytotoxic activity towards multidrug-resistant cancer cells.
    Type: Grant
    Filed: August 22, 2016
    Date of Patent: February 20, 2018
    Assignee: Macau University of Science and Technology
    Inventors: Kam Wai Wong, Man Chung Wong
  • Patent number: 9650402
    Abstract: A novel class of heterodinuclear Pt—Ru complexes are provided, and the methods for preparing the complexes are described. The inhibitory activities of the heterodinuclear Pt—Ru complexes against cancer/tumor cell growth, including cancer/tumor cells having a resistance to cisplatin, are further demonstrated.
    Type: Grant
    Filed: August 19, 2015
    Date of Patent: May 16, 2017
    Inventors: Guangyu Zhu, Lili Ma
  • Patent number: 9629382
    Abstract: The present invention provides compositions and methods for treatment of abnormal conditions in a subject, wherein the abnormal condition affects the musculoskeletal joints of the subject.
    Type: Grant
    Filed: July 20, 2009
    Date of Patent: April 25, 2017
    Assignee: Hill's Pet Nutrition, Inc.
    Inventors: Ryan Michael Yamka, Nolan Zebulon Frantz, Xiangming Gao, Samer Al-Murrani
  • Patent number: 9597334
    Abstract: Methods for treatment of a pathological condition caused by oxidative stress in a patient comprise administering to the patient a mixed metal complex of a compound of Formula I, or a salt thereof, in an amount effective to reduce the oxidative stress. The mixed metals comprise calcium and manganese in a molar ratio of calcium to manganese in the range of 1-10: wherein X, R1, R2, R3, and R4 are as defined herein.
    Type: Grant
    Filed: October 26, 2015
    Date of Patent: March 21, 2017
    Assignee: PLEDPHARMA AB
    Inventors: Jan-Olof Karlsson, Karl Reineke, Tino Kurz, Rolf Andersson, Michael Hall, Christina McLaughlin, Sven Jacobsson, Jacques Näsström
  • Patent number: 9358239
    Abstract: The accumulation of abnormal proteins in neurodegenerative disorders is considered to induce oxidative stress and lead to cell death. Thus suppression of abnormal protein aggregation and reducing oxidative stress or reactive oxygen species (ROS) are expected to inhibit a wide range of harmful downstream events, providing an observation for identifying the potential prevention and treatment of neurodegenerative disorders comprising spinocerebellar ataxia (SCA), Alzheimer's disease (AD) or Parkinson's disease (PD). In the present invention, there are several cell and animal experiment models for SCA, AD and PD established, and NiSOD-like compounds were applied to these experiment models. The results have demonstrated how NiSOD-like compounds are likely to work in suppressing abnormal protein aggregation, recovering cell viability, increasing mature neuron number and neurite outgrowth length and protecting dopaminergic cells by reducing oxidative stress or reactive oxygen species in brain tissues.
    Type: Grant
    Filed: January 26, 2015
    Date of Patent: June 7, 2016
    Assignee: National Taiwan Normal University
    Inventors: Way-Zen Lee, Guey-Jen Lee, Hsiu-Mei Hsieh, Chien-Wei Chiang, Bin Huang, Yaw-Syan Fu, Yun-Ming Wang
  • Patent number: 9351494
    Abstract: The present specification discloses honeybee repellents exhibiting repellent properties similar to 2-heptanone, compositions comprising such repellents, uses to repel a honeybee from a mammal, location, plant, structure treated of such repellents, and methods of treating a mammal, location, plant, structure by applying such repellents.
    Type: Grant
    Filed: May 3, 2014
    Date of Patent: May 31, 2016
    Assignee: Inscent, Inc.
    Inventors: Daniel F. Woods, Spiros Dimitratos, Robin W. Justice
  • Patent number: 9346830
    Abstract: A method for producing amino acid chelate compounds, characterized in that metal oxides and/or metal carbonates and/or metal sulfates and/or metal chlorides and/or metal hydroxides in solid form are activated mechanically and then the activated metal oxides and/or metal carbonates and/or metal hydroxides and/or metal sulfates and/or metal chlorides are brought together with amino acids in solid form and converted to amino acid chelate compounds in a solid-state reaction.
    Type: Grant
    Filed: November 24, 2011
    Date of Patent: May 24, 2016
    Assignee: ISF AG
    Inventors: Dietmar Ramhold, Eberhard Gock, Edmund Mathies, Wolfram Strauch
  • Patent number: 9248134
    Abstract: The invention relates to iron(III) complex compounds and pharmaceutical compositions comprising them for the use as medicaments, in particular for the treatment and/or prophylaxis of iron deficiency symptoms and iron deficiency anemias.
    Type: Grant
    Filed: March 27, 2014
    Date of Patent: February 2, 2016
    Assignee: Vifor (International) AG
    Inventors: Thomas Bark, Wilm Buhr, Susanna Burckhardt, Michael Burgert, Camillo Canclini, Franz Dürrenberger, Felix Funk, Peter O. Geisser, Aris Kalogerakis, Simona Mayer, Erik Philipp, Diana Sieber, Jörg Schmitt, Katrin Schwarz, Stefan Reim
  • Patent number: 9227966
    Abstract: The invention provides a compound of formula I: or a salt or prodrug thereof, wherein Y, W, Z, Z1, Z2, Z3, Z4, and R1-R12 have any of the values described in the specification, as well as compositions comprising a compound of formula I. The compounds are useful as antibacterial agents.
    Type: Grant
    Filed: February 21, 2014
    Date of Patent: January 5, 2016
    Assignee: Rutgers, The State University of New Jersey
    Inventors: Edmond J. LaVoie, Daniel S. Pilch, Ajit Parhi, Malvika Kaul
  • Patent number: 9204654
    Abstract: A synergistic antimicrobial composition containing zoxamide and zinc pyrithione is provided. Also provided is a method of inhibiting the growth of or controlling the growth of microorganisms in a building material by adding such a synergistic antimicrobial composition. Also provided is a coating composition containing such a synergistic antimicrobial composition, and a dry film made from such a coating composition.
    Type: Grant
    Filed: November 29, 2013
    Date of Patent: December 8, 2015
    Assignees: Dow Global Technologies LLC, Rohm and Haas Company
    Inventors: Kenneth M. Donnelly, Pierre Marie Alain Lenoir, Lukas Thomas Johannes Villiger
  • Publication number: 20150147376
    Abstract: Microparticles containing an ultraviolet light absorbing polymer and 3-iodo-2-propynyl butylcarbamate (“IPBC”) resist discoloration by sunlight and other ultraviolet light sources. Methods for preparing the microparticles produce polymer-shielded, formaldehyde-free IPBC formulations which resist discoloration and leaching, and are especially useful in water-based applications. The microparticles include a polymer or a poly(vinyl formal) homopolymer that absorbs light over a range of ultraviolet wavelengths associated with IPBC discoloration. The microparticles may be utilized in paints, stains, stuccoes, adhesives, and plastics, for example.
    Type: Application
    Filed: December 29, 2014
    Publication date: May 28, 2015
    Inventor: Jorg Thomas Wilken
  • Patent number: 9040514
    Abstract: A method of manufacturing an anhydrous copper complex of formula C12H10CICuN2O4 and methods of treating neuromuscular and other diseases, including but not limited to fibromyalgia, multiple sclerosis, muscular dystrophy, rheumatoid arthritis, pain, fatigue, sleeplessness, loss of fine motor control, speech loss, inflexibility, Alzheimer's, dementia, amyotrophic lateral sclerosis, depression, lyme disease, lyme disease co-infection, gastroparesis (GP), myopathy, chronic inflammation and/or incontinence. The anhydrous copper complex preferably is administered in a pharmaceutical and/or dietary supplement composition of the invention.
    Type: Grant
    Filed: August 9, 2012
    Date of Patent: May 26, 2015
    Inventors: Sean Kerrigan, Nolan Mente, Charles Louis Albartus Barker
  • Publication number: 20150141393
    Abstract: A composition having biocidal properties is disclosed. The composition includes a first biocide, optionally a second biocide, and a biocide enhancing agent. The first biocide may comprise an isothiazolin. The second biocide may comprise a pyrithione. The biocide enhancing agent may comprise an amine, an amine salt, an amine oxide, or mixtures thereof. The amine compound may have a carbon chain length of at least six carbon atoms, such as at least eight carbon atoms.
    Type: Application
    Filed: November 18, 2014
    Publication date: May 21, 2015
    Inventors: Scott Brown, Xiao Jiang, George Polson
  • Patent number: 9023483
    Abstract: The present invention provides a method of protecting wood or other celiulosic material from decay by copper-tolerant fungi, and wood preservative formulations for use in the same. The wood preservative formulations comprise a biocidal metal compound, a 1,2,4-triazole and a didecyl quaternary ammonium cation. Didecyldimethyl quaternary ammonium compounds are particularly preferred.
    Type: Grant
    Filed: June 21, 2011
    Date of Patent: May 5, 2015
    Assignee: Arch Timber Protection Limited
    Inventors: Craig Andrew Mars, David Grindon Cantrell, Kevin Hughes, Andrew Stewart Hughes
  • Publication number: 20150111863
    Abstract: Non-spherical liquid droplets comprising a liquid, an internal solid material defining the shape of the droplet, a benefit agent, and methods of making non-spherical liquid droplets.
    Type: Application
    Filed: October 17, 2013
    Publication date: April 23, 2015
    Applicant: The Procter & Gamble Company
    Inventors: Patrick Thomas SPICER, Marco CAGGIONI, Jessica LENIS-ABRIL, Alexandra Victoria BAYLES
  • Publication number: 20150105347
    Abstract: Shape-changing droplets, compositions comprising shape-changing droplets, methods of depositing benefit agents onto substrates using shape-changing droplets, and methods of making shape-changing droplets.
    Type: Application
    Filed: October 17, 2013
    Publication date: April 16, 2015
    Inventors: Patrick Thomas SPICER, Marco CAGGIONI, Jessica LENIS-ABRIL, Alexandra Victoria BAYLES
  • Patent number: 8980876
    Abstract: The present invention is directed to a method of inhibiting aconitase activity of fungal cells in an individual, the method comprising administering an inhibitor of aconitase activity to the fungal cell in an amount effective to inhibit activity of aconitase by said fungal cells.
    Type: Grant
    Filed: October 28, 2011
    Date of Patent: March 17, 2015
    Assignee: The Procter & Gamble Company
    Inventors: James Robert Schwartz, Charles Winston Saunders, Robert Scott Youngquist, Jun Xu
  • Publication number: 20150065476
    Abstract: A scalp care composition comprising from 1% to 99% of a volatile carrier; from 0.05% to 10% of a polymeric rheology modifier and mixtures thereof; from 0.03% to 1% of particulate scalp benefit agent wherein the composition is shear thinning and has (1) a zero shear viscosity value measured at 0.01 Pa of greater than about 1,500 Pa s; (2) a moderate stress viscosity value measured at 1 Pa viscosity of greater than about 1,000 Pa s; and (3) a high shear rate viscosity value measured at 100 1/s of less than about 0.5 Pa s.
    Type: Application
    Filed: September 5, 2014
    Publication date: March 5, 2015
    Inventors: Elizabeth Rebecca AISTRUP, James Robert SCHWARTZ
  • Patent number: 8951969
    Abstract: Provided are compositions and methods for treating or preventing nausea and vomiting in patients undergoing chemotherapy, radiotherapy, or surgery.
    Type: Grant
    Filed: November 1, 2013
    Date of Patent: February 10, 2015
    Assignee: Helsinn Healthcare SA
    Inventors: Fabio Trento, Sergio Cantoreggi, Giorgia Rossi, Roberta Cannella, Daniele Bonadeo
  • Publication number: 20150032045
    Abstract: The present invention describes Photolabile Compounds methods for use of the compounds. The Photolabile Compounds have a photoreleasable ligand, which can be biologically active, and which is photoreleased from the compound upon exposure to light. In some embodiments, the Photolabile Compounds comprise a light antenna, such as a labeling molecule or an active derivative thereof. In one embodiment, the light is visible light, which is not detrimental to the viability of biological samples, such as cells and tissues, in which the released organic molecule is bioactive and can have a therapeutic effect. In another embodiment, the photoreleasable ligand can be a labeling molecule, such as a fluorescent molecule.
    Type: Application
    Filed: December 21, 2012
    Publication date: January 29, 2015
    Inventors: Rafael Yuste, Roberto Etchenique, Luis Baraldo
  • Publication number: 20150030862
    Abstract: A mold-resistant paper is provided. The paper is coated on at least one surface with an anti-microbial coating which includes polymerized siloxane and a fungicide. An antimicrobial paper coating and related methods are provided as well. A gypsum panel with improved resistance to mold and mildew is provided as well.
    Type: Application
    Filed: December 3, 2013
    Publication date: January 29, 2015
    Applicant: United State Gypsum Company
    Inventor: Evan Vincent Rohlf
  • Patent number: 8940717
    Abstract: The present invention provides a composition having an excellent controlling activity on plant disease. The composition comprising the compound represented by the formula (1) and one or more inorganic fungicidal compound selected from the group (A) shows an excellent controlling activity on a plant disease. group (A): a group consisting of fludioxonil, pencycuron, ametoctradin, chloroneb, chlorothalonil, oxine-copper, cyflufenamid, dichlofluanid, dicloran, diethofencarb, dinocap, dithianon, edifenphos, fenaminosulf, fentin, fluazinam, fluoroimide, flusulfamide, flutianil, fosetyl-Al, hydrargaphen, iprobenfos, metrafenon, milneb, penflufen, phosdiphen, phthalide, prothiocarb, pyrazophos, sedaxane, silthiofam, spiroxamine, tebufloquin, and tolyfluanid.
    Type: Grant
    Filed: March 2, 2011
    Date of Patent: January 27, 2015
    Assignee: Sumitomo Chemical Company, Limited
    Inventors: So Kiguchi, Soichi Tanaka, Mayuko Ozawa, Atsushi Iwata
  • Publication number: 20150011523
    Abstract: The invention relates to complexes of germanium with amino acids and carboxylic acids of the general formula Ge[OH]a[AA]b[CA]c (I), where AA is an amino acid, CA is a carboxylic acid, a=0-3, b=1-3, c=0-3, and 1<b+c?4, wherein AA and AC in the complex can be identical or different, and to a method for preparing same. The method preparing an aqueous suspension of germanium dioxide, adding an amino acid and a carboxylic acid to the aqueous suspension of germanium oxide produced, heating the mixture produced with agitation at a temperature of 40-100° C. for 2-14 hours with subsequent filtering, removal of the water and production of a complex in solid form. The method makes it possible to prepare stable complexes with a controllable composition and a control fable ratio of germanium to amino acid and carboxylic acid which are stable in solid form and can be used in medicine.
    Type: Application
    Filed: November 9, 2012
    Publication date: January 8, 2015
    Inventors: Alexandr Dmitrievich Isaev, Tamaz Omarovich Manasherov, Igor Valerievich Ambrosov, Svetlana Konstantinovna Matelo
  • Patent number: 8927026
    Abstract: A shampoo composition that increases the deposition and retention of benefit agent containing polyacrylate microcapsules onto hair during the cleansing process. The shampoo composition is based on the combination of anionic charged polyacrylate microcapsules, cationic deposition polymers, detersive surfactant, and a carrier.
    Type: Grant
    Filed: April 4, 2012
    Date of Patent: January 6, 2015
    Assignee: The Procter & Gamble Company
    Inventors: Jiten Odhavji Dihora, Mark Anthony Brown
  • Publication number: 20140377384
    Abstract: The invention encompasses a formulation for hair loss prevention comprising a mixture of water and at least one nonpolar aprotic organic solvent and at least one hair loss preventive ingredient known to inhibit the hormonal mechanism underlying androgenetic hair loss and methods of using the same.
    Type: Application
    Filed: September 14, 2014
    Publication date: December 25, 2014
    Inventor: Giuseppe Trigiante
  • Patent number: 8911795
    Abstract: Compositions comprising dihydroavenanthramide D and climbazole; and, cosmetics or pharmaceutical end products comprising the compositions, useful for treating skin and/or hair.
    Type: Grant
    Filed: November 3, 2006
    Date of Patent: December 16, 2014
    Assignee: Symrise AG
    Inventors: Gerhard Schmaus, Joachim Röding
  • Publication number: 20140364407
    Abstract: A medical or therapeutic application of a composite material of ruthenium with a nitrosyl ligand. Application for a medical or therapeutic treatment of a composite material of ruthenium with a nitrosyl ligand irradiated in a spectral range capable of releasing the nitrosyl ligand, i.e., the ultraviolet or visible or near-infrared spectral range.
    Type: Application
    Filed: December 5, 2012
    Publication date: December 11, 2014
    Inventors: Isabelle Malfant, Benoit Cormary
  • Publication number: 20140348927
    Abstract: Cosmetic cleaning agents include in a cosmetically acceptable carrier a) at least one anionic surfactant, b) at least one cationic guar polymer, c) at least one silicone emulsion, in which the silicone particles have an average diameter of a maximum of 600 nm, and d) at least one wax. The cosmetic cleaning agents are suitable in particular for use as a shampoo. After application they impart improved properties to the hair treated therewith, in particular improved wet and dry combability.
    Type: Application
    Filed: August 7, 2014
    Publication date: November 27, 2014
    Inventors: Thomas Schroeder, Dirk Hentrich
  • Publication number: 20140349985
    Abstract: Disclosed are a category of platinum compounds having amino- or alkylamino-containing succinato derivatives as leaving group, or pharmaceutically acceptable salts thereof, preparation method thereof, and medicinal compositions containing the compounds. Also disclosed is a use of the compounds in treating cell proliferative diseases, especially cancers. The platinum compounds of the present invention have high water solubility and small toxic side effect.
    Type: Application
    Filed: September 18, 2012
    Publication date: November 27, 2014
    Inventors: Xiaoping Chen, Zejun Gao, Xiaoping Meng, Shouming Wen, Yashi Yan, Feng Zhao
  • Patent number: 8895041
    Abstract: A cleansing composition comprising at least 5% of a surfactant, at least about 25% water, a cyclodextrin complex comprising a perfume, wherein 80% of the plurality of perfume raw materials comprise a FDV of at least 0.69.
    Type: Grant
    Filed: March 23, 2012
    Date of Patent: November 25, 2014
    Assignee: The Procter & Gamble Company
    Inventors: Timothy Alan Scavone, Jianjun Justin Li, Marc Adam Flickinger, Jonathan Robert Cetti
  • Publication number: 20140335041
    Abstract: The present invention relates to a shampoo composition and methods of using the same. The shampoo composition includes a silicone grafted tapioca starch, a detersive surfactant, a cationic conditioning polymer, and a carrier. The shampoo composition can provide both conditioning and volume benefits.
    Type: Application
    Filed: May 10, 2013
    Publication date: November 13, 2014
    Applicant: The Procter & Gamble Company
    Inventors: Marjorie Mossman Peffly, Howard David Hutton, III
  • Publication number: 20140329792
    Abstract: The invention provides for the treatment of disorders related to viral infection, using salen manganese compounds.
    Type: Application
    Filed: November 9, 2012
    Publication date: November 6, 2014
    Inventors: John C. Kash, Jeffery K. Taubenberger, Rodney L. Levine, Susan Doctrow
  • Patent number: 8877970
    Abstract: Novel radiopharmaceuticals that are useful in diagnostic imaging and therapeutic treatment of disease characterized by over expression of CA-IX comprise a complex that contains a sulfonamide moiety which is capable of binding the active catalytic site of CA-IX, and a radionuclide adapted for radioimaging and/or radiotherapy:
    Type: Grant
    Filed: January 8, 2009
    Date of Patent: November 4, 2014
    Assignee: Molecular Insight Pharmaceuticals, Inc.
    Inventors: Craig Zimmerman, John W. Babich, John Joyal, Genliang Lu, Kevin P. Maresca, Chris Barone
  • Patent number: 8877715
    Abstract: There is provided a series of novel neuropeptide Y-cytotoxic conjugates, compositions comprising the same, and methods relating to their therapeutic use for the treatment of disease or condition states associated with aberrant or undesirable proliferation of cells that express NPY-Y1 receptors.
    Type: Grant
    Filed: August 18, 2011
    Date of Patent: November 4, 2014
    Assignee: Ipsen Pharma S.A.S.
    Inventors: Zheng Xin Dong, Kevin Zhou, Daniel B. Deoliveira
  • Publication number: 20140315875
    Abstract: The present invention relates to an antimicrobial bar soap that contains zinc pyrithione and a metal-phosphonate complex and is characterized by enhanced discoloration resistance, extended shelf life and/or increased anti-microbial efficacy.
    Type: Application
    Filed: April 17, 2014
    Publication date: October 23, 2014
    Applicant: The Procter & Gamble Company
    Inventors: Chunpeng JIANG, Zhe LIU, Juan WANG, Xiujun XU, Karl Shiqing WEI
  • Patent number: 8859533
    Abstract: A composition including a Rh or Ru metalloinsertor complex specifically targets mismatch repair (MMR)-deficient cells. Selective cytotoxicity is induced in MMR-deficient cells upon uptake of the inventive metalloinsertor complexes.
    Type: Grant
    Filed: May 10, 2012
    Date of Patent: October 14, 2014
    Assignee: California Institute of Technology
    Inventors: Jacqueline K. Barton, Alexis Komor, Curtis J. Schneider, Alyson Weidmann, Russell Ernst
  • Publication number: 20140303135
    Abstract: Personal care composition and methods are included with respect to a dried zinc pyrithione-polymer aggregate.
    Type: Application
    Filed: April 4, 2013
    Publication date: October 9, 2014
    Applicant: The Procter & Gamble Company
    Inventors: Edward Dewey SMITH, III, Jason Edward COOK, Mark William HAMERSKY
  • Publication number: 20140287009
    Abstract: One form of the present invention provides a resin composition and a molded product formed thereof, wherein a polymer composition which includes a thermoplastic base polymer or base polyblend (A), a thermoplastic base polymer or base polyblend (B) having no compatibility with the (A), and fluid (C) included as a nanoparticle suspension having compatibility with neither (A) nor (B) and containing nanoparticles uniformly dispersed at a temperature lower than or equal to the thermal decomposition temperature of (A) or (B), and in which interfaces between three layers made of (A), (B), and (C) form three-dimensional continuous parallel interfaces, and the nanoparticles of (C) having an average particle size from 1 ?m to 1 nm after removal of a dispersion medium of (C) by evaporation are locally unevenly dispersed in the pattern of a curve or a straight line connecting consecutive points at a fracture surface, and are macroscopically uniformly dispersed.
    Type: Application
    Filed: May 2, 2014
    Publication date: September 25, 2014
    Inventors: Yoshikatsu MIZUKAMI, Eiji IWASA
  • Patent number: 8840910
    Abstract: There is provided an antifouling coating composition capable of forming an antifouling coating film which has stable coating film consumption degree on ships, underwater structures and the like and which exhibits excellent antifouling property over a long term. The antifouling coating composition includes a hydrolyzable copolymer (A) and an antifouling agent (B), wherein the hydrolyzable copolymer (A) is, e.g., a metal salt bond-containing copolymer having a component unit derived from a monomer (a21) represented by the general formula (II): CH2?C(R2)—COO-M-O—CO—C(R2)?CH2??(II) [In the formula (II), M is zinc or copper, and R2 is a hydrogen atom or a methyl group], and a component unit derived from other unsaturated monomer (a22) copolymerizable with the monomer (a21), and wherein the antifouling agent (B) includes at least medetomidine.
    Type: Grant
    Filed: March 18, 2011
    Date of Patent: September 23, 2014
    Assignee: Chugoku Marine Paints, Ltd.
    Inventors: Satoshi Masuda, Yusuke Hayashi, Yukio Kozono
  • Publication number: 20140272152
    Abstract: An object of the present invention is to make it possible that a pyridine antibacterial/antifungal agent is dispersed stably in a liquid for appropriate impartation of the pyridine antibacterial/antifungal agent to fibers, and that when fibers are processed with the agent which is mixed with various other treating agents such as dyes and softeners, there is no negative influences on the process of the fibers for imparting antibacterial/antifungal properties. An antibacterial/antifungal properties-imparting agent contains a pyridine antibacterial/antifungal agent; a modified polysaccharide having reduced hydroxyl groups; and a wetting agent; but does not contain a surfactant. After applying the antibacterial/antifungal properties-imparting agent to fibers, the fibers undergo a heating process.
    Type: Application
    Filed: August 10, 2012
    Publication date: September 18, 2014
    Inventors: Kimio Suzuki, Osamu Goushi
  • Publication number: 20140256795
    Abstract: Disclosed herein is a method of promoting sustained survival, sustained regeneration, in a lesioned mature neuron, sustained compensatory outgrowth in a neuron, or combinations thereof. The method comprises contacting the lesioned mature neuron with an effective amount of an inhibitor of PTEN and an effective amount of an inhibitor of SOCS3 to thereby promote survival and/or regeneration and/or compensatory outgrowth of the neuron. Therapeutic methods of treatment of a subject with a neuronal lesion by administration of a therapeutically effective amount of an inhibitor of PTEN and a therapeutically effective amount of an inhibitor of SOCS3, are also disclosed, as are pharmaceutical compositions and devices for use in the methods.
    Type: Application
    Filed: November 1, 2012
    Publication date: September 11, 2014
    Inventors: Zhigang He, Duo Jin, Fang Su