Tin Patents (Class 514/189)
  • Publication number: 20130158362
    Abstract: Some embodiments relate to methods of treating hyperbilirubinemia comprising administrating a therapeutic amount of a metalloporphyrin to an infant. Administration may occur when the infant's measured total serum bilirubin levels are at or below about the level suggested by the AAP nomogram for initiating phototherapy, when the infant's measured total serum bilirubin levels are at about the level suggested for initiating phototherapy in an infant, or when the infant's measured total serum bilirubin levels are at about the level suggested for initiating phototherapy. Administration may occur without regard to the total serum bilirubin level of the infant. In some embodiments, administration of the metalloporphyrin does not cause QT prolongation.
    Type: Application
    Filed: November 30, 2012
    Publication date: June 20, 2013
    Applicant: INFACARE PHARMACEUTICAL CORPORATION
    Inventor: INFACARE PHARMACEUTICAL CORPORATION
  • Publication number: 20120329769
    Abstract: The present invention relates to compounds of formula (I) wherein Q is Q1 or Q2 P is P1, heterocyclylor heterocyclyl substituted by one to five Z; and wherein A1, A2, A3, A4, G1, Y1, Z, R1, R2, R3 and R4 are as defined in claim 1; or a salt or N-oxide thereof. Furthermore, the present invention relates to processes and intermediates for preparing compounds of formula (I), to insecticidal, acaricidal, nematicidal and molluscicidal compositions comprising the compounds of formula (I) and to methods of using the compounds of formula (I) to control insect, acarine, nematode and mollusc pests.
    Type: Application
    Filed: January 31, 2011
    Publication date: December 27, 2012
    Applicant: SYNGENTA CROP PROTECTION LLC
    Inventors: Myriem El Qacemi, Jerome Yves Cassayre, Julie Clementine Toueg, Peter Renold, Thomas Pitterna
  • Patent number: 8092661
    Abstract: The invention relates to novel electropolymerisable monomers which are to be polymerised in an aqueous solution and comprise: an electropolymerisable pattern selected from acetylene, pyrrols, thiophenes, indols, anilines, azines, p-phenylene vinylenes, p-phenylenes, pyrenes, furanes, selenophenes, pyrridazines, carbazoles, acrylates, methacrylates and the derivatives thereof, and a metalloporphyrine which is substituted by at least two ionised or ionizable entities in an aqueous solution. The invention also relates to a method for the polymerization of such monomers, to the electroactive probe that can be obtained by the polymerization of such monomers, and to a method for detecting a target ligand in a biological sample using one such electroactive probe.
    Type: Grant
    Filed: November 2, 2006
    Date of Patent: January 10, 2012
    Assignees: Biomerieux, Centre National de la Recherche Scientifique (CNRS), Universite Paris SUD
    Inventors: Frédéric Canonne, Hafsa Korri-Youssoufi, Jean-Pierre Mahy, Bernard Mandrand, Martine Perree-Fauvet
  • Publication number: 20110178053
    Abstract: The invention relates to novel azacarbonlines having formula (I), wherein: R3, R4 represent independently H; hal; CF3; substituted oxy, optionally substituted alkoxy; optionally substituted amino; substituted carbonyl; optionally substituted carboxyl; optionally substituted amide; sulphur, such as optionally substituted sulphones, sulphoxides or sulphides; linear, branched or cyclic C1-C10 alkyl optionally comprising an optionally substituted heteroatom; optionally substituted linear, branched or cyclic C2-C7 alkenyl; optionally substituted linear or branched C2-C6 alkynyl; optionally substituted aryl or heteroaryl; of which may be optionally substituted; in the form of a base or an acid addition salt. The invention also relates to the use of same in therapeutics for the treatment of cancer and to synthesis methods.
    Type: Application
    Filed: June 11, 2009
    Publication date: July 21, 2011
    Applicant: SANOFI-AVENTIS
    Inventors: Christopher Arendt, Didier Babin, Olivier Bedel, Thierry Gouyon, Mikhail Levit, Ronghua Li, Serge Mignani, Neil Moorcroft, David Papin
  • Publication number: 20110144079
    Abstract: The present invention relates to the use of ionic liquids as antimicrobial agents, and to the use of antimicrobial compositions comprising an ionic liquid, a film-enhancing composition and a viscosity controlling agent. The invention further relates to methods of disinfecting substrate surfaces, to substrates produced by such methods, and to novel ionic liquid compositions.
    Type: Application
    Filed: April 8, 2009
    Publication date: June 16, 2011
    Inventors: Martyn Earle, Ken Seddon, Manuela Gilea, Gabor Boberly, Brendan Gilmore, Sean Gorman, Martin McLaughlin
  • Publication number: 20100215620
    Abstract: The present invention relates to a co-culture method of Sphingomonas sp. bacterial strain and Aspergillus sp. fungus strain, in which the novel Sphingomonas sp. bacterial strain KMK-001 is cultured in a liquid medium and the novel Aspergillus sp. strain KMC-901 separately cultured in another liquid medium is added to the above culture solution, a novel glionitrin biosynthesized therefrom and a pharmaceutical composition comprising the said glionitrin or its pharmaceutically acceptable salt as an active ingredient. The glionitrin herein has strong cytotoxic effect on cancer cells and has antibiotic effect on 10 pathogenic bacteria including the novel Sphingomonas sp. bacterial strain KMK-001, so that it can be effectively applied in antibiotics or anti-cancer agents.
    Type: Application
    Filed: October 23, 2008
    Publication date: August 26, 2010
    Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
    Inventors: Hyun Ok Yang, Hak Cheol Kwon, Hyun-Bong Park, Ji-Hye Yoo
  • Publication number: 20100168042
    Abstract: The invention relates to novel insecticidal active compound combinations comprising, firstly, cyclic ketoenols or other acaricidally active compounds and, secondly, further insecticidally active compounds from the group of the anthranilamides, which combinations are highly suitable for controlling animal pests, such as insects and unwanted acarids.
    Type: Application
    Filed: March 9, 2010
    Publication date: July 1, 2010
    Applicant: BAYER CROPSCIENCE AG
    Inventors: Christian Funke, Thomas Bretscheneider, Reiner Fischer, Rüdiger Fischer, Heike Hungenberg, Wolfram Andersch, Wolfgang Thielert, Ánton Kraus
  • Publication number: 20080261939
    Abstract: Pharmaceutical compositions including stannsoporfin, drug products incorporating pharmaceutical compositions, methods of making pharmaceutical compositions, and methods of treating hyperbilirubinemia with drug products and compositions are disclosed.
    Type: Application
    Filed: April 22, 2008
    Publication date: October 23, 2008
    Inventors: George S. Drummond, Philip C. Lang
  • Patent number: 7375215
    Abstract: A tetrakis(hydroxyphenyl)chlorin, bacteriochlorin or isobacteriochlorin, derivatised at one or more of the hydroxy groups by addition reaction with a diisocyanate, diisothiocyanate or isocyanate-isothiocyanate at one isocyanate or isothiocyanate group thereof, the other isocyanate or isothiocyanate group being itself derivatised by addition reaction with the hydroxy group of an w-alkylated or acylated poly(alkylene oxide) or to a hydroxy group of a link residue itself carrying a residue of such poly(alkylene oxide).
    Type: Grant
    Filed: March 8, 2001
    Date of Patent: May 20, 2008
    Assignee: Bioscience Technology Investment Holdings Limited
    Inventors: Paul Bradley, Mehar Manku
  • Patent number: 7323452
    Abstract: A method for accelerating the process of removing ethanol from the blood through the use of certain additives that accelerate the metabolic oxidation of ethanol, and others which in addition act as catalysts or “pseudo” enzymes for the oxidation. These additives include multivalent transition metal ions, as well as complexes thereof, and NAD+ which enhance the oxidation reaction. The method described can act as a sobriety inducer and/or as an effective palliative for the unpleasant effects of overuse of ethanol.
    Type: Grant
    Filed: December 20, 2004
    Date of Patent: January 29, 2008
    Assignee: Wardan, L.L.C.
    Inventors: Ward B. Bowen, Jr., Daniel S. Daniel
  • Patent number: 7205289
    Abstract: The invention relates to novel active compound combinations of certain cyclic ketoenols and certain insecticidally active compounds that together have very good insecticidal and acaricidal properties.
    Type: Grant
    Filed: January 27, 2004
    Date of Patent: April 17, 2007
    Assignee: Bayer Aktiengesellschaft
    Inventors: Reiner Fischer, Christoph Erdelen, Thomas Bretschneider
  • Patent number: 7011854
    Abstract: Several classes of in vivo carbon monoxide-releasing compounds are useful for the treatment and/or prevention of diseases, such as chronic inflammatory, e.g., rheumatoid arthritis, and of diseases with a strong inflammatory component, such as atherosclerosis, stroke, coronary disease, and Alzheimers disease. The in vivo carbon monoxide-releasing compounds can be attached to known drug vectors and/or known anti-inflammatory drugs, such as aspirin.
    Type: Grant
    Filed: February 3, 2003
    Date of Patent: March 14, 2006
    Assignee: Alfama-Investigacao e Desenvolvimento de Produtos Farmaceuticos Lda
    Inventors: Werner Haas, Carlos Romao, Beatriz Roya, Ana Cristina Fernandes, Isabel Goncalves
  • Patent number: 6906050
    Abstract: Substituted porphyrin and azaporphyrin deviations with various substitutents in the 12- and 17-positions of the porphyrin skeleton as pharmaceutical agents for use in photodynamic therapy, MRI diagnosis, and radiodiagnostics.
    Type: Grant
    Filed: May 31, 2002
    Date of Patent: June 14, 2005
    Assignee: Miravant Pharmaceuticals, Inc.
    Inventor: Byron C. Robinson
  • Patent number: 6833362
    Abstract: A composition for accelerating the disposal of ethanol from bodily fluid. Certain additives can accelerate the metabolic oxidation of ethanol, and others in addition act as catalysts or “pseudo” enzymes for the oxidation. Additives include the oxidant Nicotinamide Adenine Dinucleotide and a variety of other additives such as transition metal ions and complexes thereof which favor the oxidation reaction. The compositions described can act as a sobriety inducer and/or as an effective palliative for the unpleasant effects of overuse of ethanol.
    Type: Grant
    Filed: June 7, 2001
    Date of Patent: December 21, 2004
    Inventors: Ward Beryl Bowen, Jr., Daniel Salman Daniel
  • Patent number: 6630172
    Abstract: Disinfectant formulations are described which are preferably ecologically friendly and non-toxic to mammals and plants, and are highly effective against a broad spectrum of detrimental pathogenic microorganisms. The microbicidal formulation contains complexes having at least one metal ion which is microbicidal to at least one microorganism and potassium sodium tartrate in some form. When potassium sodium tartrate is used with these metal ions, it enhances the complex-forming properties of such metal complexes while concurrently increases their efficacy and potency at the same level of metal ion concentrations. These microbicidal formulations can be diluted in suitable proportions into aqueous systems to produce the desired dosages for each individual case, depending on the level and the severity of the contamination. The microbicidal formulations can be applied by conventional methods, e.g., spraying, soaking, fogging, impregnation, and the like.
    Type: Grant
    Filed: January 22, 2001
    Date of Patent: October 7, 2003
    Inventor: Kareem I. Batarseh
  • Patent number: 6608050
    Abstract: The present invention relates to a pharmaceutically acceptable dosage form of water insoluble porphyrins, particularly metal containing porphyrins such as tin porphyrin, which can be complexed with a lipid, reconstituted from a lyophilizate and administrated to a patient in the treatment of cancer and other diseases.
    Type: Grant
    Filed: October 4, 2001
    Date of Patent: August 19, 2003
    Assignee: Pharmacia & Upjohn Company
    Inventors: Mathew Cherian, Shireesh Prakash Apte
  • Patent number: 6602487
    Abstract: Methods for producing coronary vasospasms and for inhibiting coronary vasospasms are disclosed. Both in vivo and in vitro methods are disclosed. The methods are useful as tests for determining the ability of a chemical compound to inhibit or reduce coronary vasospasms.
    Type: Grant
    Filed: August 16, 2000
    Date of Patent: August 5, 2003
    Assignee: Dimera Incorporated
    Inventor: R. Kent Hermsmeyer
  • Publication number: 20030053955
    Abstract: An insect pest eradication system comprised of a non-lethal knockout agent and an insecticide. The present invention also relates to a method of eradicating insects, particularly those found in earthen colonies, by treating the insects with a non-lethal knockout agent, such as trans-dichloroethylene, in combination with a suitable insecticide for the targeted insects.
    Type: Application
    Filed: October 2, 2001
    Publication date: March 20, 2003
    Inventor: Tommy G. Taylor
  • Patent number: 6384027
    Abstract: Disclosed are compounds of formula V wherein M is selected from: a metal atom; a metal compound; 2H whereby one H is bonded to each of the two nitrogen atoms depicted as being bonded to M (positions 29 and 31 shown) R3 is H or methyl; R1 and R4 are independently selected from: H, C1 to C4 alkyl, C2 to C4 alkenyl, methoxy, butoxy, propoxy, NH2, NH—(C1 to C4 alkyl), N—(C1 to C4 alkyl)2, S—(C1 to C4 alkyl); R8 to R25 are the same or different and are independently selected from: C1 to C32 alkyl; C2 to C32 alkenyl; X—O—Y; X—phenyl, X2COOX1, X2CONR1R11, H; halide; wherein: X and X2 are independently selected from: a chemical bond, —(CH2)n— wherein n is an integer from 1 to 32, —(CH2)a—CH═CH(CH2)b where a and b are independently selected from integers 0-32 and a+b totals 32; X1 and Y are independently selected from: C1 to C32 alkyl, C2 to C32 alkenyl, and H; R1 and R11 are independently selected from: H; C1 to C32 alkyl, C2 to C
    Type: Grant
    Filed: April 18, 2000
    Date of Patent: May 7, 2002
    Assignee: QinetiQ Limited
    Inventor: Michael J Cook
  • Patent number: 6316652
    Abstract: The invention relates to novel targeting drug agents that are targeted for entry into the mitochondria. More specifically, the agents are cisplatin derivatives called mitoplatins which are useful as anti-tumor agents. Mitoplatins are named for their targeting to the mitochondrial DNA via the carnitine-acylcarnitine translocase system. The invention also relates to methods of synthesizing mitoplatins, compositions of matter containing mitoplatins and methods of using the mitoplatins.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: November 13, 2001
    Inventor: Kosta Steliou
  • Publication number: 20010039270
    Abstract: Tin polyaalkanecarboxylates having the formula [(R1pR2qSn)rOs]t wherein R1 represents C1-C6 alkyl, branched or straight, substituted or not by one or more hydroxyl groups or halogen atoms, or a phenyl group, substituted or not by one or more hydroxyl groups or halogen atoms, R2 is carboxylic residue selected from (I), (II), (III) or (IV); and p, q, r, s and t have the following meanings: P=3, q=1, r=1, s=) and t=1, p=2, q=2, r=1, s=0, and t=1, p=2, q=1, r=2, s=1 and t=2, have anti-tumor activity.
    Type: Application
    Filed: January 29, 2001
    Publication date: November 8, 2001
    Inventors: Marcel Gielen, Rudolph Willem, Monique Biesemans, Martine Kemmer, Dick de Vos
  • Patent number: 6287541
    Abstract: The invention relates to an oral care composition with antiplaque agents. The antiplaque agents are complexes of divalent copper, zinc, iron or tin, or trivalent iron with a specific class of cyclic &agr;-hydroxyketones. A typical example is the copper (II)-ethylmaltol complex. These complexes are more active antiplaque agents that e.g. copper-hinokitiol complexes.
    Type: Grant
    Filed: September 23, 1999
    Date of Patent: September 11, 2001
    Assignee: Chesebrough-Pond's USA Co., divison of Conopco, Inc.
    Inventors: Jonathan E. Creeth, Keiran Molloy, Philip Wright
  • Publication number: 20010007868
    Abstract: Methods and compositions of matter are provided that enable a phased reduction of body iron stores to near a iron deficiency level, and thereafter maintain the body iron stores at that level by reducing further iron accumulation. In a first phase, a patient's body iron stores are reduced to a level of near iron deficiency by regular periodic phlebotomy or use of pharmacological agents, such as iron chelators, for example, over a period of six to twelve months. In a second phase, ingested iron absorption is controlled using an oral dose, taken at mealtimes, of any of various compounds that inhibit intestinal iron absorption, or by continuing, less frequent phlebotomy.
    Type: Application
    Filed: June 4, 1999
    Publication date: July 12, 2001
    Inventor: FRANCESCO FACCHINI
  • Patent number: 6147070
    Abstract: Methods and compositions of matter are provided that enable a phased reduction of body iron stores to near a iron deficiency level, and thereafter maintain the body iron stores at that level by reducing further iron accumulation. In a first phase, a patient's body iron stores are reduced to a level of near iron deficiency by regular periodic phlebotomy or use of pharmacological agents, such as iron chelators, for example, over a period of six to twelve months. In a second phase, ingested iron absorption is controlled using an oral dose, taken at mealtimes, of compound comprising a calcium salt and salts of phytic acid, without or without zinc, or by continuing, less frequent phlebotomy.
    Type: Grant
    Filed: June 5, 1998
    Date of Patent: November 14, 2000
    Inventor: Francesco Facchini
  • Patent number: 6133252
    Abstract: A method of controlling Take-all disease of plants by applying, preferably to the seed prior to planting, a fungicide of the formula ##STR1## wherein Z.sub.1 and Z.sub.2 are C or N and are part of an aromatic ring selected from benzene, pyridine, thiophene, furan, pyrrole, pyrazole, thiazole, and isothiazole;A is selected from --C(X)-amine, --C(O)--SR.sub.3, --NH--C(X)R.sub.4, and --C(.dbd.NR.sub.3)--XR.sub.7 ;B is --W.sub.m --Q(R.sub.2).sub.3 or selected from o-tolyl, 1-naphthyl, 2-naphthyl, and 9-phenanthryl, each optionally substituted with halogen or R.sub.4 ;Q is C, Si, Ge, or Sn;W is --C(R.sub.3).sub.p H.sub.(2-p) --; or when Q is C, W is selected from --C(R.sub.3).sub.p H.sub.(2-p) --, --N(R.sub.3).sub.m H.sub.(1-m) --, --S(O).sub.p --, and --O--;X is O or S;n is 0, 1, 2, or 3;m is 0 or 1;p is 0, 1, or 2;each R is independently selected from functional groups disclosed the specification.
    Type: Grant
    Filed: November 4, 1998
    Date of Patent: October 17, 2000
    Assignee: Monsanto Company
    Inventors: Dennis Paul Phillion, Diane Susan Braccolino, Matthew James Graneto, Wendell Gary Phillips, Karey Alan Van Sant, Daniel Mark Walker, Sai Chi Wong
  • Patent number: 5916885
    Abstract: A locally administrable topical pharmaceutical composition is provided for prevention or treatment of skin conditions associated with hyperproliferation of skin cells and/or an immunologically mediated disorder, e.g., psoriasis, atopical dermatitis, contact dermatitis, seborrhoeic dermatitis, lupus and the like. The composition contains a topical carrier and spirogermanium or a structurally related azaspirane. Also provided are methods for using the novel composition and laminated patches which may be applied to the skin to administer the composition thereto.
    Type: Grant
    Filed: July 29, 1997
    Date of Patent: June 29, 1999
    Inventor: Lawrence R. Bernstein
  • Patent number: 5843936
    Abstract: A locally administrable topical pharmaceutical composition is provided for use in the prevention or treatment of skin conditions associated with hyperproliferation of keratinocytes and/or an immunologically mediated disorders, as psoriasis, atopic dermatitis, contact dermatitis, seborrheic dermatitis or actinic dermatitis. The composition contains a topical carrier and spirogermanium or a structurally related azaspirane.
    Type: Grant
    Filed: June 28, 1996
    Date of Patent: December 1, 1998
    Inventor: Lawrence R. Bernstein
  • Patent number: 5811411
    Abstract: A method of controlling Take-all disease of plants by applying, preferably to the seed prior to planting, a fungicide of the formula ##STR1## wherein Z.sub.1 and Z.sub.2 are C and are part of an aromatic ring that is thiophene;A is selected from --C(X)-amine, --C(O)--SR.sub.3, --NH--C(X)R.sub.4, and --C(.dbd.NR.sub.3)--XR.sub.7 ;B is --W.sub.m --Q(R.sub.2).sub.3 or selected from o-tolyl, 1-naphthyl, 2-naphthyl, and 9-phenanthryl, each optionally substituted with halogen or R.sub.4 ;Q is C, Si, Ge, or Sn;W is --C(R.sub.3).sub.p H.sub.(2-p) --; or when Q is C, W is selected from --C(R.sub.3).sub.p H.sub.(2-p) --, --N(R.sub.3).sub.m H.sub.(1-m) --, --S(O).sub.p --, and --O--;X is O or S;n is 0, 1, 2, or 3;m is 0 or 1;p is 0, 1, or 2;R, R.sub.2, R.sub.3, R.sub.4 and R.sub.7 are herein defined;or an agronomic salt thereof.
    Type: Grant
    Filed: November 22, 1996
    Date of Patent: September 22, 1998
    Assignee: Monsanto Company
    Inventors: Dennis Paul Phillion, Diane Susan Braccolino, Matthew James Graneto, Wendell Gary Phillips, Karey Alan Van Sant, Daniel Mark Walker, Sai Chi Wong
  • Patent number: 5504075
    Abstract: A process is provided for oxidatively modifying nucleic acids containing a target nucleotide. The nucleic acid is contacted with a polyaza metal complex in the presence of an oxidizing agent so that the nucleic acid is modified at or near the target nucleotide. Also provided are a kit for carrying out the process and a method for treating neoplastic growth by administering to a subject having neoplastic growth, an effective amount of a polyaza metal complex which is capable of modifying DNA.
    Type: Grant
    Filed: September 28, 1993
    Date of Patent: April 2, 1996
    Assignee: The Research Foundation of State University of New York
    Inventors: Cynthia J. Burrows, Steven E. Rokita, Xiaoying Chen
  • Patent number: 5011959
    Abstract: The present invention comprises a water-soluble square-planar cis-platinum(II) four-coordinate complex having the formula:trans-R,R-DACH Pt(II) X.sub.2ortrans-R,R-DACH Pt(II) Ywherein X is a monovalvent cation, two of which are present, selected from the group consisting of cyclopropanecarboxylato, shikimato, saccharatolactone, galacturonato and N,N-dimethyglycinato; wherein Y is a divalent cation selected from the group consisting of citraconato, 1,1-cyclobutanedicarboxylato, 1,1-cyclopropanedicarboxylato, isocitratolactone and Z-iminodiacetato where Z is bound to the nitrogen and is ethyl, propyl, Isopropyl, n-butyl, sec-butyl, ter-butyl, n-amyl, isoamyl or OH.In one preferred aspect the water-soluble square-planar cis-platinum(II) four-coordinate complex has the formula:trans-R,R-DACH Pt(II) X.sub.2wherein X is a monovalent cation. Two X substituents are present in the platinum complex.
    Type: Grant
    Filed: November 17, 1986
    Date of Patent: April 30, 1991
    Assignee: The Board of Regents, The University of Texas System
    Inventors: Abdul R. Khokhar, Robert A. Newman, Irwin H. Krakoff
  • Patent number: 4971989
    Abstract: Substituted 1-arylpyrazoles useful in combating insects having the arachnida and nematodes of the formula ##STR1## in which R.sup.1 represents hydrogen or alkyl,R.sup.2 represents alkyl or halogenoalkyl,R.sup.3 represents hydrogen or alkanoyl,R.sup.4 represents hydrogen, alkyl, hydroxyalkyl, alkoxyalkyl, alkylthioalkyl, halogenoalkyl, alkenyl, halogenoalkenyl or alkinyl, in each case optionally substituted cycloalkyl, aralkyl or aryl, or, when X represents oxygen or sulphur, R.sup.4 can represent a cation equivalent which is bonded in a salt-like manner,A represents a double-linked alkylene radical,X represents oxygen, sulphur or a radical ##STR2## Ar represents optionally substituted phenyl, pyridyl and n represents a number 0, 1 or 2, where R.sup.5 represents hydrogen, alkyl, hydroxylalkyl, alkoxyalkyl, alylthioalkyl, halogenoalkyl, alkenyl, halogenoalkenyl or alkinyl, or represents optionally substituted cycloalkyl, aralkyl or aryl.
    Type: Grant
    Filed: March 22, 1990
    Date of Patent: November 20, 1990
    Assignee: Bayer Aktiengesellschaft
    Inventors: Uta Jensen-Korte, Schallner, Otto, Benedikt Becker, Jurgen Hartwig, Wilhelm Stendel
  • Patent number: 4935408
    Abstract: A compound of the formula: ##STR1## in which R.sup.1 represents alkyl, cycloalkyl or aralkyl, R* represents fluorophenyl or trifluoromethylphenyl when R.sup.1 is alkyl; R* represents dichlorophenyl, neopentyl, trimethylsilylmethyl, dimethylphenylsilylmethyl or a group of the formula: ##STR2## wherein R.sup.2 represents halogen, trifluoromethyl, lower alkyl or lower alkoxy when R.sup.1 is cycloalkyl; or R* represents 2-thienyl, 3-thienyl, neopentyl, trimethylsilylmethyl, dimethylphenylsilylmethyl or a group of the formula: ##STR3## wherein R.sup.3, R.sup.4 and R.sup.5 independently represent halogen, trifluoromethyl, lower alkyl or lower alkoxy when R.sup.1 is aralkyl, m represents 1 or 2, and X represents halogen, imidazolyl, triazolyl, phenylthio or a radical selected from the group consisting of: ##STR4## wherein R.sup.6 represents alkyl, R.sup.7 and R.sup.8 independently represent lower alkyl and R.sup.9 and R.sup.
    Type: Grant
    Filed: May 6, 1988
    Date of Patent: June 19, 1990
    Assignees: Shionogi & Co., Ltd., Nitto Kasei Co., Ltd.
    Inventors: Hideyuki Imazaki, Masazumi Fujikawa, Katsuaki Oba, Fusaharu Kumayama, Toshio Takahashi
  • Patent number: 4843068
    Abstract: A pyrazole oxime derivative represented by the general formula (I) which is useful as an insecticide and fungicide, ##STR1## wherein the structural elements are defined in the specification, and the method of controlling said pests. The compounds represented by the general formula (I) can be synthesized by the methods disclosed in the specification.
    Type: Grant
    Filed: December 29, 1986
    Date of Patent: June 27, 1989
    Assignee: Nihon Nohyaku Co., Ltd.
    Inventors: Hiroshi Hamaguchi, Hideo Takaishi, Tetsuji Ohshima, Takamichi Konno, Yukio Miyagi, Shiraiwa Yutaka, Takayuki Akita
  • Patent number: 4774235
    Abstract: A compound of the formula: ##STR1## in which R.sup.1 represents alkyl, cycloalkyl or aralkyl, R* represents fluorophenyl or trifluoromethylphenyl when R.sup.1 is alkyl; R* represents dichlorophenyl, neopentyl, trimethylsilylmethyl, dimethylphenylsilylmethyl or a group of the formula: ##STR2## wherein R.sup.2 represents halogen, trifluoromethyl, lower alkyl or lower alkoxy when R.sup.1 is cycloalkyl; or R* represents 2-thienyl, 3-thienyl, neopentyl, trimethylsilylmethyl, imethylphenylsilylmethyl or a group of the formula: ##STR3## wherein R.sup.3, R.sup.4 and R.sup.5 independently represent hydrogen, halogen, trifluoromethyl, lower alkyl or lower alkoxy when R.sup.1 is aralkyl, m represents 1 or 2, and X represents halogen, imidazolyl, triazolyl, phenylthio or a radical selected from the group consisting of: ##STR4## wherein R.sup.6 represents alkyl, R.sup.7 and R.sup.8 independently represent lower alkyl and R.sup.9 and R.sup.
    Type: Grant
    Filed: August 21, 1986
    Date of Patent: September 27, 1988
    Assignees: Shionogi & Co., Ltd., Nitto Kasei Co., Ltd.
    Inventors: Hideyuki Imazaki, Masazumi Fujikawa, Katsuaki Oba, Fusaharu Kumayama, Toshio Takahashi
  • Patent number: 4732894
    Abstract: Compounds of the formula ##STR1## wherein Het is a 5- or 6-membered aromatic heterocyclic ring containing 1 to 2 ring nitrogen atoms and the remaining ring atoms carbon atoms optionally substituted with 1 to 2 substituents independently selected from halo, nitro, trihalomethyl, lower alkyl of 1 to 3 carbon atoms, or lower alkoxy of 1 to 3 carbon atoms; R is alkyl of 1 to 7 carbon atoms; R.sup.1 is aryl of 6 to 10 carbon atoms, lower alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 8 carbon atoms, all optionally substituted with 1 to 3 halogen atoms; and a is 0 or 1 are fungicidal and insecticidal, with the proviso that a ring nitrogen is not bonded to the hydroxamic acid ##STR2## moiety.
    Type: Grant
    Filed: December 6, 1984
    Date of Patent: March 22, 1988
    Assignee: Chevron Research Company
    Inventor: William F. King
  • Patent number: 4690942
    Abstract: The invention relates to 1-aryl-2-fluoro-2-azolyl alkanones, alkanols, esters and ethers of formula I ##STR1## wherein Az is 1H-1,2,4-triazole, 4H-1,2,4-triazole or 1H-imidazole;T is --C(O)--, --CH(OH)-- or one of the groups ##STR2## wherein R.sub.7 is C.sub.1 -C.sub.6 alkyl which is unsubstituted or substituted by C.sub.1 -C.sub.3 -alkoxy, halogen or cyano, or is C.sub.3 -C.sub.6 alkenyl, C.sub.3 -C.sub.6 alkynyl, C.sub.3 -C.sub.6 cycloalkyl, 2-furyl, 2-tetrahydrofuryl, or is phenyl or benzyl, each unsubstituted or substituted by halogen, nitro, C.sub.1 -C.sub.3 -alkyl, C.sub.1 -C.sub.3 alkoxy, C.sub.1 -C.sub.3 haloalkyl and/or C.sub.1 -C.sub.3 haloalkoxy;R.sub.8, R.sub.9 and R.sub.10 are each independently hydrogen, nitro, halogen, cyano, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy, C.sub.1 -C.sub.3 haloalkoxy, --COO(C.sub.1 -C.sub.3 alkyl), NH.sub.2 or NHCOCH.sub.3 ;R is hydrogen or C.sub.1 -C.sub.6 alkyl;R.sub.1 and R.sub.2 are each independently hydrogen, halogen, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.
    Type: Grant
    Filed: December 14, 1984
    Date of Patent: September 1, 1987
    Assignee: CIBA-GEIGY Corporation
    Inventors: Willy Frick, Alfred Meyer, Robert Nyfeler
  • Patent number: 4690947
    Abstract: Arthropodicidal compositions in the form of synergistic combinations of (A) cyano-(4-fluoro-3-phenoxyphenyl)-methyl 3-(2,2-dichlorovinyl)-2,2-dimethyl-cyclopropanecarboxylate plus (B) O-ethyl-O-[4-(methylthio)-phenyl]-S-propyl phosphorodithioate, (A) plus (C) N.sup.1 -(4-chloro-O-tolyl)-N,N-dimethylformamidine, (A) plus (B) plus (C), (A) plus (D) 1-(tricyclohexylstannyl)-1H-1,2,4-triazole, (A) plus (E) tricyclohexyl hydroxystannane, or (A) plus (F) hexakis-(2-methyl-2-phenylpropyl)-distannoxane, which are individually known compounds, which combinations possess synergistic arthropidicidal properties especially for the control of mites.
    Type: Grant
    Filed: November 25, 1985
    Date of Patent: September 1, 1987
    Assignee: Mobay Corporation
    Inventors: Walter M. Zeck, Donald E. Simonet
  • Patent number: 4622333
    Abstract: Hydroxyalkynyl-azolyl derivatives of the formula ##STR1## in which Az is 1,2,4-triazolyl or imidazolyl,X is optionally substituted phenyl or alkyl,R is ##STR2## R.sup.1 is hydrogen or halogen, R.sup.2 is halogen,R.sup.3 is alkylthio, halogenoalkoxy, halogenoalkylthio, alkenyl, alkoxycarbonyl or cyano, or in each case optionally substituted phenyl, phenoxy, phenylthio, phenylalkoxy or phenylalkylthio,n is 0, 1 or 2,m is 0 or 1, andHet is optionally substituted dioxolanyl or dioxanyl,or an addition product thereof with acids or metal salts, which exhibit fungicidal activity.
    Type: Grant
    Filed: November 1, 1983
    Date of Patent: November 11, 1986
    Assignee: Bayer Aktiengesellschaft
    Inventors: Reinhard Lantzsch, Klaus Ditgens, Karl H. Buchel, Paul Reinecke, Wilhelm Brandes
  • Patent number: 4619923
    Abstract: Method of controlling the rate of tryptophan metabolism in the liver of humans by parenteral administration of tin or chromium protoporphyrin to increase the rate, and the administration of cobalt protoporphyrin to decrease the rate.
    Type: Grant
    Filed: January 14, 1985
    Date of Patent: October 28, 1986
    Assignee: The Rockefeller University
    Inventors: Attallah Kappas, George S. Drummond
  • Patent number: 4587239
    Abstract: 1-Azolyl-3-pyrazolyl-2-propanol derivatives of the general formula ##STR1## in which Az represents 1,2,4-triazol-1-yl, imidazol-1-yl or pyrazol-1-yl andR represents alkyl, alkenyl, alkinyl, optionally substituted phenyl, optionally substituted phenylalkyl, optionally substituted phenylalkenyl, optionally substituted phenylalkinyl, naphthyl or optionally substituted cycloalkyl,and acid addition salts and metal salt complexes thereof, which possess fungicidal activity. Oxirane intermediates lacking Az are also new.
    Type: Grant
    Filed: March 22, 1984
    Date of Patent: May 6, 1986
    Assignee: Bayer Aktiengesellschaft
    Inventors: Erik Regel, Karl H. Buchel, Paul Reinecke, Wilhelm Brandes
  • Patent number: 4584308
    Abstract: A method of combating fungi which comprises to such fungi or to a fungus habitat a fungicidally effective amount of a substituted hydroxyalkyl-azole of the formula ##STR1## in which R.sup.1 is optionally substituted phenyl, --O-phenyl, --S-phenyl, --SO-phenyl, --SO.sub.2 -phenyl, --CH.sub.2 --phenyl, --CH.sub.2 --O-phenyl, --CH.sub.2 --S-phenyl, --CH.sub.2 --SO-phenyl or --CH.sub.2 --SO.sub.2 -phenyl,R.sup.2 is alkyl,R.sup.3 is alkyl,X is a nitrogen atom or the CH group,Y is halogen, alkyl, cycloalkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy, halogenoalkylthio, optionally substituted phenyl, optionally substituted phenylalkyl or optionally substituted phenylalkoxy, andm is 0, 1, 2 or 3,or an addition product thereof with an acid or metal salt.
    Type: Grant
    Filed: November 23, 1983
    Date of Patent: April 22, 1986
    Assignee: Bayer Aktiengesellschaft
    Inventors: Hans-Ludwig Elbe, Karl H. Buchel, Wilhelm Brandes, Paul Reinecke, Hans-Jurgen Rosslenbroich
  • Patent number: 4582828
    Abstract: Compounds of the formula: ##STR1## wherein R is aryl of 6 to 10 carbon atoms; substituted aryl substituted with 1 to 5 substituents selected from halogen, nitro, lower alkyl of 1 to 6 carbon atoms, lower alkoxy of 1 to 6 carbon atoms, lower alkylthio of 1 to 6 carbon atoms, trihalomethyl, or ##STR2## wherein R.sup.2 is lower alkyl of 1 to 4 carbon atoms; alkyl of 1 to 8 carbon atoms; cycloalkyl of 3 to 8 carbon atoms; 1-alkylcycloalkyl of 4 to 9 carbon atoms; 1-alkylthio-1,1-dialkylmethyl of 4 to 7 carbon atoms; 1-alkoxy-1,1-dialkylmethyl of 4 to 7 carbon atoms; furyl; thienyl; or pyridyl; and R.sup.1 is lower alkyl of 1 to 6 carbon atoms, cycloalkyl of 3 to 8 carbon atoms, aryl of 6 to 10 carbon atoms, substituted aryl of 6 to 10 carbon atoms substituted with 1 to 5 lower alkyl groups of 1 to 6 carbon atoms or aralkyl of 7 to 12 carbon atoms are fungicidal.
    Type: Grant
    Filed: October 16, 1984
    Date of Patent: April 15, 1986
    Assignee: Chevron Research Company
    Inventor: Laroy H. Edwards
  • Patent number: 4565812
    Abstract: Compounds of the formula: ##STR1## wherein Z is sulfur or oxygen; R is alkyl of 1 to 7 carbon atoms; R.sup.1 is aryl of 6 to 10 carbon atoms, lower alkyl of 1 to 6 carbon atoms or cycloalkyl of 3 to 8 carbons, all optionally substituted with 1 to 3 halogen atoms; a is 0 or 1; b is 0, 1, or 2; X is independently halo, nitro, trihalomethyl, lower alkyl of 1 to 3 carbon atoms, or lower alkoxy of 1 to 3 carbon atoms are useful as fungicides and insecticides.
    Type: Grant
    Filed: November 30, 1984
    Date of Patent: January 21, 1986
    Assignee: Chevron Research Company
    Inventor: William F. King
  • Patent number: 4549900
    Abstract: Substituted 1-azolyl-but-2-ones and -2-ols of the formula ##STR1## in which B is --CO-- or --CH(OH)--Az represents a 1,2,4-triazol-1-yl or -4-yl or imidazol-1-yl radical,R.sup.1 represents a hydrogen atom, an alkyl, alkenyl, alkinyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted phenoxyalkyl or optionally substituted aralkyl radical,n is 0 or 1,R.sup.2 represents a cyano radical or a grouping of the general formula --X--R.sup.3 or --CO--NR.sup.4 R.sup.5, or, if n does not represent O at the same time as R.sup.1 represents a hydrogen atom and Az represents a 1,2,4-triazolyl radical,R.sup.2 also additionally represents an optionally substituted aryl or alkoxycarbonyl radical,and whereinX represents an oxygen or sulphur atom or an SO or SO.sub.2 group,R.sup.3 represents an alkyl, halogenoalkyl, optionally substituted aryl or optionally substituted aralkyl radical,R.sup.4 represents a hydrogen atom or an alkyl or optionally substituted aryl radical, andR.sup.
    Type: Grant
    Filed: April 4, 1983
    Date of Patent: October 29, 1985
    Assignee: Bayer Aktiengesellschaft
    Inventors: Wolfgang Kramer, Karl H. Buchel, Hans-Ludwig Elbe, Udo Kraatz, Erik Regel, Paul-Ernst Frohberger, Wilhelm Brandes, Klaus Lurssen
  • Patent number: 4548945
    Abstract: Substituted 1-hydroxyethyl-triazole derivatives of the formula ##STR1## in which R represents optionally substituted alkyl, optionally substituted cycloalkyl or optionally substituted phenyl,X represents the grouping --OCH.sub.2 --, --SCH.sub.2 --, --(CH.sub.2)p-- or --CH.dbd.CH--,Y represents the grouping --CO--Y.sup.1 or an acetal or ketal derivative thereof, or the grouping --C(Y.sup.1).dbd.N--OY.sup.2,Y.sup.1 represents hydrogen, alkyl, alkenyl, alkinyl, optionally substituted cycloalkyl, optionally substituted phenyl or optionally substituted benzyl,Y.sup.2 represents hydrogen, alkyl, alkenyl, alkinyl, optionally substituted cycloalkyl or optionally substituted benzyl,Z represents halogen, alkyl, alkoxy, alkylthio, halogenoalkyl, halogenoalkoxy or halogenoalkylthio andthe indices m and p represent 0, 1 or 2,or addition products thereof with acids or metal salts which possess fungicidal activity.
    Type: Grant
    Filed: September 21, 1983
    Date of Patent: October 22, 1985
    Assignee: Bayer Aktiengesellschaft
    Inventors: Graham Holmwood, Jorg Stetter, Karl H. Buchel, Paul Reinecke, Wilhelm Brandes, Hans Scheinpflug
  • Patent number: 4522825
    Abstract: There are described mixtures with a synergistic action of two acaricide compounds as well as their use in suitable compositions in the fight against mite infestations on useful plants.
    Type: Grant
    Filed: March 31, 1983
    Date of Patent: June 11, 1985
    Assignee: Montedison S.p.A.
    Inventors: Giovanni Regiroli, Vincenzo Caprioli, Angelo Longoni
  • Patent number: 4517194
    Abstract: The invention relates to microbicidal mandelic acid derivatives of the formula I ##STR1## wherein X is the bridge member --CH.dbd. or --N.dbd.,Ar is a phenyl, diphenyl or naphthyl group,R.sub.1, R.sub.2 and R.sub.3 independently of one another are hydrogen, nitro, halogen, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 alkoxy or C.sub.1 -C.sub.3 haloalkyl,R is one of the groups ##STR2## R.sub.5 is C.sub.2 -C.sub.10 alkenyl which is unsubstituted or substituted by halogen; C.sub.2 -C.sub.10 alkynyl which is unsubstituted or substituted by halogen; or is a C.sub.3 -C.sub.8 cycloalkyl group or a phenyl group which is unsubstituted or substituted; or is a C.sub.1 -C.sub.12 alkyl chain which from C.sub.2 alkyl may be interrupted by oxygen or sulfur and is unsubstituted or substituted by a member selected from the group consisting of halogen, phenyl, --COO--C.sub.1 --C.sub.4 alkyl, --CO--C.sub.1 --C.sub.
    Type: Grant
    Filed: June 13, 1983
    Date of Patent: May 14, 1985
    Assignee: Ciba-Geigy Corporation
    Inventors: Walter Kunz, Wolfgang Eckhardt
  • Patent number: 4497806
    Abstract: Antifungal and antibacterial compounds, compositions containing the same, and method of using the same comprising triorganotin 5-nitro-2-furoates represented by Formula (I) ##STR1## wherein R, which may be the same or different, is an alkyl group, a cycloalkyl group, an aryl group or an aralkyl group, as the active ingredient.
    Type: Grant
    Filed: February 22, 1983
    Date of Patent: February 5, 1985
    Assignee: St. John's University
    Inventors: Eugene J. Kupchik, Michael A. Pisano
  • Patent number: 4497647
    Abstract: The invention relates to novel azolyl-olefin derivatives of the general formula I ##STR1## wherein R.sub.1 is an azolyl group,R.sub.2 is C.sub.1 -C.sub.12 alkyl, C.sub.3 -C.sub.8 cycloalkyl, C.sub.1 -C.sub.4 alkyl substituted by unsubstituted or substituted phenyl, C.sub.1 -C.sub.4 alkoxycarbonyl or C.sub.2 -C.sub.6 alkenyl, or is C.sub.3 -C.sub.8 cycloalkyl which is substituted by 1 to 4 C.sub.1 -C.sub.4 alkyl groups,R.sub.3 is C.sub.1 -C.sub.12 alkyl, C.sub.3 -C.sub.8 cycloalkyl which is substituted by 1 to 4 C.sub.1 -C.sub.4 alkyl groups, or is the --C(R.sub.4)(R.sub.5)--[CH(R.sub.4)].sub.n --X--R.sub.6 group, wherein n is 0 or 1 andR.sub.4 and R.sub.5, each independently of the other, are hydrogen or C.sub.1 -C.sub.4 alkyl,X is oxygen or sulfur,R.sub.6 is a radical selected from the group consisting of C.sub.1 -C.sub.8 alkyl, C.sub.3 -C.sub.8 cycloalkyl, C.sub.3 -C.sub.6 alkenyl, C.sub.3 -C.sub.
    Type: Grant
    Filed: February 16, 1983
    Date of Patent: February 5, 1985
    Assignee: Ciba-Geigy Corporation
    Inventors: Alfred Meyer, Walter Kunz, Ludwig Maier, Hermann Rempfler