Monocyclic Cyclopentyl Ring Bonded Directly To The Seven-membered Hetero Ring (e.g., Prostaglandins, Etc.) Patents (Class 514/211.02)
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Patent number: 11952388Abstract: Disclosed are crystal form A and crystal form B of a compound represented by formula (I), and application thereof in the preparation of medicaments for treating HBV-related diseases.Type: GrantFiled: August 23, 2019Date of Patent: April 9, 2024Assignee: Fujian Akeylink Biotechnology Co., Ltd.Inventors: Jing Wang, Zhigan Jiang, Haiying He, Yaxun Yang
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Patent number: 8557281Abstract: A pharmaceutical controlled release composition in solid dosage form is provided which comprises (I) a water-swell able linear polymer obtainable by reacting together: (a) a polyethylene oxide; (b) a C5 to C20 diol; and (c) a diisocyanate; and (II) a releasable pharmaceutically active agent.Type: GrantFiled: July 13, 2010Date of Patent: October 15, 2013Assignee: Ferring B.V.Inventors: Janet A. Halliday, Jukka Tuominen, Mark Livingstone, Frank Koppenhagen, Lilias Currie, Sarah Stewart
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Patent number: 7985746Abstract: The invention relates to compounds of formula I: along with pharmaceutical compositions containing the same and methods of use thereof for the treatment of autoimmune disease.Type: GrantFiled: May 24, 2007Date of Patent: July 26, 2011Assignee: Eisai R&D Management Co., Ltd.Inventors: Francis Fang, Shawn Schiller, Boris Seletsky, Mark Spyvee
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Publication number: 20110091488Abstract: A pharmaceutical controlled release composition in solid dosage form is provided which comprises (I) a water-swellable linear polymer obtainable by reacting together: (a) a dried polyethylene oxide; (b) a dried C5 to C20 diol; and (c) a Bifunctional diisocyanate; and (II) a releasable pharmaceutically active agent.Type: ApplicationFiled: July 13, 2010Publication date: April 21, 2011Applicant: CONTROLLED THERAPEUTICS (SCOTLAND) LIMITEDInventors: Janet A. HALLIDAY, Jukka TUOMINEN, Mark LIVINGSTONE, Frank KOPPENHAGEN, Lilias CURRIE, Sarah STEWART
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Publication number: 20100331287Abstract: 6-(Aminoalkyl)indazoles of formula (I) and the salts thereof have renin-inhibiting properties and can be used as antihypertensive, and renal, cardiac and vascular protecting medicinally active ingredients.Type: ApplicationFiled: March 30, 2007Publication date: December 30, 2010Inventors: John J. Baldwin, David A. Claremon, Lawrence W. Dillard, Alexey V. Ishchenko, Jing Yuan, Zhenrong Xu, Gerard McGeehan, Wenguang Zeng
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Publication number: 20100189765Abstract: The present invention provides implantable ocular drug delivery devices. Generally, the devices have a distal portion with a coil shaped body member and a proximal portion which contacts the sclera. In one aspect, the coil-shaped body member includes a unique configuration including two coiled portions with different pitches, which improves insertion of the device into the eye. In another aspect, the device has a proximal portion that includes a unique cap configuration having a concave distal face that improves stabilization of the device in the eye. In another aspect, the device includes a transitional portion between the cap and the coil-shaped body member that also improves stabilization of the device in the eye. The invention also provides methods for inserting the medical device into the eye, and methods for the treatment of an ocular condition.Type: ApplicationFiled: November 25, 2009Publication date: July 29, 2010Inventors: Signe R. Erickson, Jianbo Zhou, Krip Punja, Nathan R.F. Beeley
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Publication number: 20090286769Abstract: A method for treating hair loss in mammals uses compositions containing prostaglandin F analogs. The compositions can be applied topically to the skin. The compositions can arrest hair loss, reverse hair loss, and promote hair growth.Type: ApplicationFiled: August 4, 2009Publication date: November 19, 2009Applicant: DUKE UNIVERSITYInventors: Mitchell Anthony DeLong, John McMillan McIver, Robert Scott Youngquist
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Patent number: 7507816Abstract: Pharmaceutical compositions containing substituted aminoalcohols, the use of preparations containing substituted aminoalcohols for treatment of conditions such as pain, emesis, neurotropic conditions, cardiovascular diseases, urinary incontinence, diarrhea, pruritus, alcohol or drug dependency, inflammation, depression, decreased vigilance, or depressed libido, as well as 2-(aminomethyl)cycloalkane-1-ol compounds and a process for their preparation.Type: GrantFiled: June 14, 2004Date of Patent: March 24, 2009Assignee: Gruenenthal GmbHInventors: Heinz Uragg, Corinna Maul, Helmut Buschmann, Bernd Sundermann, Hagen-Heinrich Hennies
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Patent number: 7498360Abstract: A novel method and compositions for the local treatment of Meniere's disease, tinnitus and hearing loss are described. The treatment is based on the administration of a therapeutically effective amount of a prostaglandin of the F-type to the inner ear. The treatment can be either continuous or intermittent and may involve the use of pumps, gels, or slow release drug inserts.Type: GrantFiled: January 15, 2002Date of Patent: March 3, 2009Assignee: Synphora ABInventors: Helge Rask-Andersen, Johan Stjernschantz
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Publication number: 20080318927Abstract: Compounds of formula I: (wherein variables A1, A2, A2, A4, m, n, J, Q, R4, Ea, Eb, Ec, R6, R7, Re, Rf, RPG and Y are as described herein) which are antagonists of CGRP receptors and which are useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.Type: ApplicationFiled: June 19, 2008Publication date: December 25, 2008Inventors: Michael R. Wood, Steven N. Gallicchio, Harold G. Selnick, C. Blair Zartman, Ian M. Bell, Craig A. Stump
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Publication number: 20080081803Abstract: The present invention is directed to compounds of the formula I: Wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, X, n and the broken lines are as defined herein which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.Type: ApplicationFiled: October 15, 2004Publication date: April 3, 2008Inventors: Gabor Butora, Stephen D. Goble, Alexander Pastemak, Lihu Yang, Changyou Zhou, Christopher R. Moyes
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Patent number: 7320973Abstract: The present invention provides dihydrodiaryloxazepine derivative represented by the following formula [1], analogs thereof and pharmaceutical compositions containing them.Type: GrantFiled: December 1, 2003Date of Patent: January 22, 2008Assignee: Ajinomoto Co., Inc.Inventors: Katsutoshi Sakata, Takashi Tsuji, Munetaka Tokumasu, Kazuyoshi Takahashi, Shigeo Hirasawa, Junko Ezaki
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Patent number: 7153845Abstract: A bioadhesive controlled, extended release progressive hydration composition wherein the active ingredient may be protected from water or the surrounding environment, thereby protecting it from metabolism or from other degradation caused by moisture, enzymes, or pH effects, and making it bioavailable only at a controlled rate. The active ingredient may be protected from moisture during the manufacturing process, as necessary or desired, and more importantly may be protected from moisture and the immediate septic environment until well after the patient has applied the composition, and then only at a slow and controlled rate. It is by this process of progressive hydration that the active ingredient remains protected for many hours after administration. It is also by the process of progressive hydration that controlled and sustained release is achieved because only that part of the active ingredient that is the hydrated (aqueous) fraction of the composition is available for absorption (bioavailable).Type: GrantFiled: April 24, 2003Date of Patent: December 26, 2006Assignee: Columbia Laboratories, Inc.Inventors: Howard L. Levine, William J. Bologna, Philippe J. Cartier, Dominique De Ziegler
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Patent number: 7147859Abstract: It relates to an Association of chemical agents, with intended pharmacological action to prevent the risk of infarction and brain hemorrhage caused by the development of the atherosclerotic process and of the homocysteinemia resulting from ageing. It is of the utmost importance to prevent the increase of endogenous homocysteine. High levels of homocysteine in blood, caused by genetical error and further biologic circumstances impart damaging consequences upon the human organism (occlusion of blood vessels, ocular modifications, osteoporosis and nervous system).Type: GrantFiled: June 10, 2002Date of Patent: December 12, 2006Assignee: Laboratorios Biosintetica LTDA.Inventors: Roberto Luis Bruno, Marcio Falci
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Patent number: 6787155Abstract: An oral pharmaceutical dosage form including a mixture of a delay release formulation of a non-steroidal anti-inflammatory drug (NSAID) and a mixture containing a prostaqlandin and one or more excipients.Type: GrantFiled: December 9, 2002Date of Patent: September 7, 2004Assignee: Norton Healthcare Ltd.Inventors: Austen John Woolfe, Siobhan Greene, Gordon McIntyre, Nitin Vadilal Sheth
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Patent number: 6656969Abstract: The invention provides for methods of monitoring the proliferation of cultured prostate cancer cells in the presence of omega-3 fatty acids, methods of treating an individual with prostate cancer or at risk of developing prostate cancer, and methods of reducing the risk of recurrence of prostate cancer in an individual who had previously been treated for prostate cancer. Methods of the invention further include treating an individual with benign prostatic hyperplasia (BPH) with omega-3 fatty acids as well as methods of screening for compounds that inhibit the proliferation of prostate cancer cells. The invention provides for compositions and articles of manufacture containing omega-3 fatty acids in particular formulations, and omega-3 fatty acids with a second compound that also exerts an effect on the androgen receptor.Type: GrantFiled: September 20, 2001Date of Patent: December 2, 2003Assignee: Mayo Foundation for Medical Education and ResearchInventor: Charles Young