Nitrogen Bonded Directly To Ring Carbon Of The Seven-membered Hetero Ring Patents (Class 514/211.13)
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Publication number: 20100022511Abstract: A pharmaceutical composition that contains an atypical antipsychotic drug and succinic acid, fumaric acid or a mixture of succinic acid and fumaric acid.Type: ApplicationFiled: September 5, 2008Publication date: January 28, 2010Inventors: Fang-Yu Liu, Zhi-qun Shen
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Publication number: 20100016283Abstract: Formula (I) below: and their pharmaceutically acceptable salts or tautomers, compositions and methods of use thereof. These novel compounds provide a treatment or prophylaxis of at least one symptom or condition associated with schizophrenia and other psychotic disorders, dementia and other cognitive disorders, anxiety disorders, mood disorders, sleep disorders, disorders usually first diagnosed in infancy, childhood, or adolescence and neurodegenerative disorders.Type: ApplicationFiled: December 19, 2007Publication date: January 21, 2010Applicant: ASTRAZENECA ABInventors: Peter Bernstein, James B. Campbell
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Publication number: 20100016284Abstract: This invention relates to novel compounds having the structural Formula I below: and their pharmaceutically acceptable salts or tautomers, compositions and methods of use thereof. These novel compounds provide a treatment or prophylaxis of at least one symptom or condition associated with schizophrenia and other psychotic disorders, dementia and other cognitive disorders, anxiety disorders, mood disorders, sleep disorders, disorders usually first diagnosed in infancy, childhood, or adolescence and neurodegenerative disorders.Type: ApplicationFiled: December 19, 2007Publication date: January 21, 2010Applicant: ASTRAZENECA ABInventors: Peter Bernstein, James B. Campbell
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Publication number: 20090318414Abstract: The invention relates to the use of a functional muscarinic M1/M4 agonist or a pharmaceutically acceptable salt thereof to treat prodromal syndrome and in the manufacture of a medicament for the treatment of prodromal syndrome, and to a method of treatment of prodromal syndrome using a functional muscarinic M1/M4 agonist or a pharmaceutically acceptable salt thereof. It also relates to the use of a pharmaceutical composition comprising a functional muscarinic M1/M4 agonist or a pharmaceutically acceptable salt thereof, and at least one cholinergic agent and/or at least one non-cholinergic agent for the treatment of prodromal syndrome, and to a method of treatment of prodromal syndrome by administration of a such a pharmaceutical composition.Type: ApplicationFiled: April 23, 2007Publication date: December 24, 2009Inventors: Paul Christopher Sharpe, Peter Robin Blower, Jill Galloway Chisnall Rasmussen
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Publication number: 20090317471Abstract: The present invention includes a controlled-release composition having a matrix. The matrix contains a pharmaceutically effective amount of an active agent or a pharmaceutically acceptable salt or solvate thereof, an ionic non-gelling matrix polymer, and a pH modifier. The ionic non-gelling matrix polymer is practically insoluble and unswellable at a first aqueous fluid pH and is soluble at a second aqueous fluid pH. The pH modifier is present in an amount to control the release of the active agent from the composition. The controlled-release composition is substantially free of a gelling or swellable excipient and does not contain a functional coating or a lipophilic component. The present invention also provides methods of making and using the controlled-release compositions.Type: ApplicationFiled: December 8, 2008Publication date: December 24, 2009Inventors: Gandha V. Naringrekar, Kristin A. Arnold, David Erkoboni
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Publication number: 20090318415Abstract: Compounds the following formula: wherein Z is as described in the specification, pharmaceutically acceptable salts thereof, compositions comprising the same, and methods of treating bipolar disorder, an anxiety disorder, a mood disorder or schizophrenia or other psychotic disorder with said compounds.Type: ApplicationFiled: June 19, 2009Publication date: December 24, 2009Applicant: AstraZeneca ABInventors: Dean Brown, James R. Damewood, Phil Edwards, James M. Hulsizer, James Campbell Muir, M. Edward Pierson, Jr., Ashokkumar Bhikkappa Shenvi, Steven Wesolowski, Dan Widzowski, Michael Wood
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Publication number: 20090311347Abstract: Treatment regimens for mood disorders that include administration of buprenorphine, alone or in combination with additional pharmacological agents are described. Specifically, treatment regimens that alleviate racing thoughts associated with bipolar disorder, and pharmaceutical compositions and kits for use therein are described. Dosing regimens, compositions, and kits including buprenorphine for treating mania associated with opioid withdrawal are also described.Type: ApplicationFiled: April 10, 2009Publication date: December 17, 2009Inventors: Bryan T. Oronsky, Neil C. Oronsky
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Publication number: 20090291939Abstract: Certain atypical antipsychotic medications (particularly clozapine) or combinations of medications are useful to treat alcohol or other substance abuse, particularly in the general (non-schizophrenic) population. Generally stated, one aspect of the invention features a method of treating a patient suffering from alcohol or other substance abuse by administering to the patient medication effective to rectify an abuse-associated dysfunction in the DA-mediated brain reward circuit. A second aspect of the invention features administering medication that strongly antagonizes ?2 andrenergic receptors and weakly antagonizes dopamine D2 receptors. Preferably, the ratio of ?2 receptor blockade to D2o receptor blockade is similar to that of clozapine. The medication may be a single compound (such as clozapine or risperidone), or it may include two or more compounds which together achieve the specified function.Type: ApplicationFiled: August 5, 2009Publication date: November 26, 2009Inventors: Alan I. Green, Wing Ming Keung, Joseph Schildkraut, David Chau
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Publication number: 20090291152Abstract: This invention relates to novel 11-[4-[2-(2-Hydroxyethoxy)ethyl]piperazin-1-yl]dibenzo[b,f][1,4]thiazepine derivatives, their acceptable acid addition salts, solvates, hydrates and polymorphs thereof. The invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions beneficially treated by antagonists of seratonergic 5HT1A and 5HT2 receptors, dopaminergic D1 and D2 receptor, histaminergic H1 receptors, and/or adrenergic ?1 and ?2 receptors.Type: ApplicationFiled: April 17, 2009Publication date: November 26, 2009Applicant: Concert Pharmaceuticals Inc.Inventors: Roger Tung, Scott Harbeson
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Patent number: 7622461Abstract: Disclosed herein are analogs of clozapine and pharmaceutically acceptable salts, esters, amides, or prodrugs thereof, methods of synthesizing the analogs; and methods of using the analogs for treating neuropsychiatric disorders. In some embodiments, the analogs are amino substituted diaryl[a,d]cycloheptenes.Type: GrantFiled: April 10, 2007Date of Patent: November 24, 2009Assignee: ACADIA Pharmaceuticals Inc.Inventors: Fredrik Ek, Roger Olsson, Jörgen Ohlsson
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Publication number: 20090281078Abstract: The invention relates to adjunctive and simultaneous combination therapies for the treatment of psychotic disorders in which sabcomeline or a pharmaceutically acceptable salt thereof and at least one other neuroleptic agent are administered adjunctively or simultaneously. The invention provides methods of treatment of psychotic disorders utilising such adjunctive or simultaneous therapeutic combination therapies, therapeutic combinations for use therein and pharmaceutical compositions comprising them.Type: ApplicationFiled: July 16, 2009Publication date: November 12, 2009Inventors: Carol ROUTLEDGE, James Joseph Hagan, Stuart Paul Cuffe
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Publication number: 20090275541Abstract: A method of treating corticosteroid-induced cognitive impairment comprises administering an effective amount of at least one compound of formula I, or pharmaceutically acceptable salts thereof, to a subject in need of such treatment. Formula I is: wherein: A is a bridge selected from the following radicals: —(CH2)m—, —CH?CH—, —(CH2)p—O—, —(CH2)p—S—, —(CH2)p—SO2—, —(CH2)p—NR1— and —SO2—NR2—, and wherein: m is an integer of from 1 to 3 inclusive; p is an integer selected from 1 and 2; R1 is selected from the group consisting of hydrogen and C1-C5 alkyl; and R2 is C1-C5 alkyl; X and Y are independently selected from the group consisting of hydrogen and halogen; R and R? are independently selected from the group consisting of hydrogen and C1-C5 alkyl; n is an integer from 1 to 12 inclusive; and * denotes an asymmetric carbon.Type: ApplicationFiled: May 5, 2008Publication date: November 5, 2009Inventor: Gregory M. Sullivan
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Publication number: 20090264408Abstract: The present invention relates to an extended release dosage form of quetiapine wherein the dosage form comprises quetiapine and rate-controlling polymer selected from polyethylene oxide, sodium alginate and natural gum and combinations thereof. The dosage form may additionally comprise at least one water-insoluble polymer.Type: ApplicationFiled: April 8, 2009Publication date: October 22, 2009Inventors: Inder Gulati, Rajan Kumar Verma, Rajeev Singh Raghuvanshi, Romi Barat Singh, Kumaravel Vivek, Sweta Varshney
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Publication number: 20090239840Abstract: Disclosed herein are analogs of clozapine and pharmaceutically acceptable salts, esters, amides, or prodrugs thereof; methods of synthesizing the analogs; and methods of using the analogs for treating neuorpsychiatric disorders. In some embodiments, the analogs are amino substituted diaryl[a,d]cycloheptenes.Type: ApplicationFiled: February 12, 2009Publication date: September 24, 2009Applicant: ACADIA PHARMACEUTICALS, INC.Inventors: Fredrik Ek, Roger Olsson, Jorgen Ohlsson
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Patent number: 7592333Abstract: The invention relates to novel compounds and methods of using them for modulating sleep.Type: GrantFiled: September 21, 2005Date of Patent: September 22, 2009Assignee: Hypnion, Inc.Inventors: Dale M. Edgar, David G. Hangauer, Kazumi Shiosaki, Michael Solomon, James F. White
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Publication number: 20090221553Abstract: This invention is directed to a method of treating sexual dysfunction in a subject, comprising the step of administering a therapeutically effective amount of a compound of Formula (I): or a pharmaceutically acceptable salt or ester thereof wherein Rx is a member selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, halogen selected from F, CI, Br and I, alkoxy containing 1 to 3 carbon atoms, nitro, hydroxy, trifluoromethyl, and thioalkoxy containing 1 to 3 carbon atoms; x is an integer of 1 to 3, with the proviso that R may be the same or different when x is 2 or 3; R1 and R2 can be the same or different from each other and are independently selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, aryl, arylalkyl, cycloalkyl of 3 to 7 carbon atoms; R1 and R2 can be joined to form a 5 to 7-membered heterocycle substituted with a member selected from the group consisting of hydrogen, alkyl, and aryl groups, wherein the cyclic compound can comprise 1 to 2Type: ApplicationFiled: June 13, 2006Publication date: September 3, 2009Inventors: Joseph Palumbo, Jonathan Sporn, Thomas Steckler, Yong Moon Choi, James S. Lee
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Publication number: 20090220593Abstract: The present invention relates to multiple unit extended release dosage forms of quetiapine for oral administration, wherein each unit comprises a core containing quetiapine and one or more of pharmaceutically acceptable excipients coated with a rate-controlling coating and process for the preparation thereof.Type: ApplicationFiled: January 28, 2009Publication date: September 3, 2009Inventors: Inder GULATI, Rajan Kumar Verma, Rajeev Singh Raghuvanshi
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Publication number: 20090215744Abstract: The present invention is directed to solid formulations of the pharmaceutical compound 11-piperazin-1-yldibenzo[b,f][1,4]thiazepine as well as preparations, and pharmaceutical uses thereof.Type: ApplicationFiled: November 18, 2006Publication date: August 27, 2009Applicant: ASTRAZENECA ABInventors: Dan B. Brown, Daniel Korey, Karen B. Main, Richard J.R. Creekmore
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Publication number: 20090209474Abstract: The present invention relates to novel therapeutic uses of tianeptine, salts, isomers, pro-drugs, metabolites and structural analogs thereof. Furthermore, the present invention relates to the use of tianeptine, salts, isomers, pro-drugs, metabolites and structural analogs thereof, in obtaining methods of screening and of developing drugs. Finally, the present invention relates to the novel therapeutic use of other glutamine synthetase (GS) ligands and to the use of these ligands in obtaining methods for screening and developing drugs.Type: ApplicationFiled: August 8, 2006Publication date: August 20, 2009Applicant: NEWTHERAInventors: Jean-Christophe Roegel, Pierre Eftekhari
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Publication number: 20090186872Abstract: The invention relates to novel compounds and methods of using them for modulating sleep.Type: ApplicationFiled: March 25, 2009Publication date: July 23, 2009Inventors: Dale M. Edgar, David G. Hangauer, Kazumi Shiosaki, Michael Solomon, James F. White
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Patent number: 7563785Abstract: The invention relates to novel compounds and methods of using them for modulating sleep.Type: GrantFiled: September 21, 2005Date of Patent: July 21, 2009Assignee: Hypnion, Inc.Inventors: Dale Edgar, David Hangauer, Kazumi Shiosaki, Michael Solomon, James White
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Publication number: 20090181943Abstract: This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula compounds of the Formula (I) and N-oxides, hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof, and racemic and scalemic mixtures, diastereomers and enantiomers thereof, wherein groups L, M, X and Y are as defined herein.Type: ApplicationFiled: April 9, 2008Publication date: July 16, 2009Applicant: METHYLGENE INC.Inventors: Pierre Tessier, Silvana Leit, David Smil, Robert Deziel, Alain Ajamian, Yves Andre Chantigny, Celia Dominguez
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Publication number: 20090176745Abstract: Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are triphenyl methane analogs. The compounds and compositions can be used to treat and/or prevent a wide variety of cancers, including drug resistant cancers, inflammatory, degenerative and vascular diseases, including various ocular diseases, and parasitic infections. Representative triphenyl methane analogs include triphenyl methane analogues of various dyes, hormones, sugars, peptides, oligonucleotides, amino acids, nucleotides, nucleosides, and polyols. The compounds are believed to function by inhibiting tNOX expression, the effects of ROS, and/or the production of HIF2. Thus, the compounds are novel therapeutic agents for a variety of cancers and other diseases.Type: ApplicationFiled: December 29, 2008Publication date: July 9, 2009Applicant: Emory UniversityInventor: Jack L. Arbiser
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Patent number: 7550454Abstract: Disclosed herein are analogs of clozapine and pharmaceutically acceptable salts, esters, amides, or prodrugs thereof; methods of synthesizing the analogs; and methods of using the analogs for treating neuropsychiatric disorders. In some embodiments, the analogs are amino substituted diaryl[a,d]cycloheptenes.Type: GrantFiled: December 21, 2004Date of Patent: June 23, 2009Assignee: ACADIA Pharmaceuticals, Inc.Inventors: Fredrik Ek, Roger Olsson, Jörgen Ohlsson
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Publication number: 20090149442Abstract: The present invention provides novel compounds of Formula I: The invention further relates to pharmaceutical compositions comprising compounds of Formula I and to methods of using compounds of Formula I to treat neuropsychiatric disorders (e.g., psychosis, depression, schizophrenia).Type: ApplicationFiled: January 25, 2007Publication date: June 11, 2009Inventors: Shitij Kapur, Robert McClelland
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Publication number: 20090111792Abstract: Disclosed in certain embodiments is a method for relieving pain at a site in a human or animal in need thereof, comprising administering by injection or infiltration, a dose of a capsaicinoid and coadministering a tricyclic antidepressant.Type: ApplicationFiled: October 16, 2008Publication date: April 30, 2009Applicant: AlgoRxInventors: Ronald M. Burch, Richard B. Carter, Jeff Lazar
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Publication number: 20090099151Abstract: Novel modified release pharmaceutical composition comprising at least one active agent(s); a polymer system in an amount less than about 80% w/w of the composition comprising at least two swellable pH independent polymers wherein at least one is hydrophilic; optionally other pharmaceutically acceptable excipients is provided. Process for preparation of such compositions and methods of using them is also provided. The compositions are formulated into suitable dosage forms that provide therapeutic concentrations of active agent for extended periods of time.Type: ApplicationFiled: June 29, 2006Publication date: April 16, 2009Applicant: PANACEA BIOTEC LTD.Inventors: Rajesh Jain, Kour Chand Jindal, Sukhjeet Singh, Sanjay Boldhane
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Patent number: 7517871Abstract: Disclosed herein are analogs of clozapine and pharmaceutically acceptable salts, esters, amides, or prodrugs thereof; methods of synthesizing the analogs; and methods of using the analogs for treating neuorpsychiatric disorders. In some embodiments, the analogs are amino substituted diaryl[a,d]cycloheptenes.Type: GrantFiled: May 3, 2006Date of Patent: April 14, 2009Assignee: Acadia Pharmaceuticals, Inc.Inventors: Fredrik Ek, Roger Olsson, Jörgen Ohlsson
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Publication number: 20090093460Abstract: Pharmaceutical compositions, oral pharmaceutical compositions, and solid dosage forms comprising up to about 750 mg of 11-piperazin-1-yldibenzo[b,f] [1,4]thiazepine, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or diluent are provided.Type: ApplicationFiled: June 13, 2008Publication date: April 9, 2009Applicant: AstraZeneca ABInventors: Patricia C. Davis, Jeffrey M. Goldstein, Scott W. Grimm, Raymond F. Suckow, Helen R. Winter
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Publication number: 20090093461Abstract: Methods of treating at least one symptom or condition associated with Anxiety Disorders and/or Mood Disorders comprising administering an effective amount of a compound of Formula I or its pharmaceutically acceptable salt are provided herein.Type: ApplicationFiled: June 13, 2008Publication date: April 9, 2009Applicant: ASTRAZENECA ABInventors: Patricia C. Davis, Jeffrey Goldstein, Scott W. Grimm, Raymond F. Suckow, Helen R. Winter
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Publication number: 20090082334Abstract: The present application describes deuterium-enriched quetiapine, pharmaceutically acceptable salt forms thereof, and methods of treating using the same.Type: ApplicationFiled: August 22, 2008Publication date: March 26, 2009Applicant: PROTIA, LLCInventor: Anthony W. Czarnik
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Publication number: 20090075974Abstract: Disclosed is a pharmaceutical composition for prophylaxis and treatment of pancreatitis comprising a 5-HT2A receptor antagonist as an effective component, wherein the binding activity (pKi) of the 5-HT2A receptor antagonist to a 5-HT2A receptor is higher at least by 1.0 than the binding activities to a 5-HT2B receptor and a 5-HT2C receptor. Preferably the binding activity (pKi) of the 5-HT2A receptor antagonist to the 5-HT2A receptor is at least 7.0, and more preferably at least 8.0. The present invention also provides a method of identifying a candidate substance for prophylactic and therapeutic agent for pancreatitis, comprising determining whether a test substance has a 5-HT2A receptor antagonistic activity.Type: ApplicationFiled: April 27, 2006Publication date: March 19, 2009Applicant: UMN Pharma Inc.Inventors: Isamu Yamaguchi, Kentaro Hamada, Yasunari Kashihara
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Publication number: 20090069267Abstract: The present invention concerns compositions, methods and/or apparatus of central administration of various CNS-active agents. In particular embodiments, intrathecal administration is advantageous for decreasing the systemic concentrations of CNS agent, thereby decreasing side effect toxicity, while allowing more effective delivery of the agent to the site of action, simultaneously decreasing the dosage delivered to the subject. In particular embodiments, ICV delivery may be of use for patients who have previously proven to be refractory to systemic administration of CNS agents, in some cases due to systemic side effects, or for those patients whose symptoms are of sufficient severity to warrant more aggressive therapeutic intervention. ICV administration allows not only lower systemic concentration but also higher therapeutically effective concentration within the CNS.Type: ApplicationFiled: July 25, 2008Publication date: March 12, 2009Inventors: Daniel J. Abrams, Raymond Bunch, Tom Anchordoquy, Karen E. Stevens
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Publication number: 20090069292Abstract: The present invention is directed to liquid formulations of the pharmaceutical compound 1 1-piperazin-1-yldibenzo[b,f][1,4]thiazepine as well as preparations, and pharmaceutical uses thereto.Type: ApplicationFiled: November 18, 2006Publication date: March 12, 2009Applicant: ASTRAZENECA ABInventors: Daniel Korey, Karen B. Main, Richard J.R. Creekmore, Jean M. Surian, Vivian Y. Bi
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Publication number: 20090069291Abstract: The present invention is directed to salts the pharmaceutical compound 11-piperazin-1-yldibenzo[b,f][1,4]thiazepine as well as compositions, preparations, and pharmaceutical uses thereof.Type: ApplicationFiled: November 18, 2006Publication date: March 12, 2009Applicant: ASTRAZENECA ABInventors: Alan S. Kirschner, James A. Osborn, James Hulsizer
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Publication number: 20090062254Abstract: Methods of treating headache with antipsychotics are provided. A kit for treating headache is also provided, comprising an antipsychotic and a device for rapid delivery of the antipsychotic.Type: ApplicationFiled: October 3, 2008Publication date: March 5, 2009Applicant: ALEXZA PHARMACEUTICALS, INC.Inventors: Ron L. Hale, Peter M. Lloyd, Amy T. Lu, Patrik Munzar, Joshua D. Rabinowitz, Roman Skowronski
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Publication number: 20090048229Abstract: The present invention relates to methods of promoting wakefulness in an individual by administering a carbamoyl ester or a pharmaceutically acceptable salt thereof.Type: ApplicationFiled: July 18, 2008Publication date: February 19, 2009Inventors: Nadia M.J. Rupniak, James F. White
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Publication number: 20090035370Abstract: A method for treating a medical condition for which quetiapine is indicated in a subject comprises comprising orally administering to the subject quetiapine or a pharmaceutically acceptable salt thereof in a daily dosage amount effective to treat said condition; wherein the quetiapine or salt thereof is administered in one to a plurality of dosage forms collectively comprising (a) a major quetiapine component in immediate-release form in a sedative effective amount, administered not earlier than about 3 hours prior to the start of a sleep period; and (b) either (i) a minor quetiapine component in extended-release, delayed extended-release or delayed pulsed-release form, wherein time of administration and release properties of the minor component provide substantial onset of release of quetiapine therefrom not earlier than about 6 hours after the start of the sleep period, or (ii) a plurality of minor quetiapine components in immediate-release form, administered sequentially during a waking period following thType: ApplicationFiled: July 31, 2008Publication date: February 5, 2009Applicant: DRUGTECH CORPORATIONInventors: Jonathan David Bortz, Michael Norman Grimshaw
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Publication number: 20090029967Abstract: There is disclosed a method for the treatment or prevention of Extra Pyramidal syndrome (EPS), dystonia, restless leg syndrome (RLS) or periodic leg movement in sleep (PLMS) comprising the administration of an adenosine A2a receptor antagonist, alone or in combination with other agents useful for treating EPS, dystonia, RLS or PLMS.Type: ApplicationFiled: July 29, 2008Publication date: January 29, 2009Inventors: Michael Grzelak, John Hunter, Annamarie Pond, Geoffrey Vaity
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Publication number: 20090023705Abstract: The present invention provides pharmaceutical compositions comprising droxidopa alone, or in combination with one or more further active ingredients, for the treatment of conditions, such as mood disorders, sleep disorders, or attention deficit disorders. In certain embodiments, the compositions useful in the methods of the invention comprise droxidopa and a compound selected from the group consisting of DOPA decarboxylase inhibiting compounds, catechol-O-methyltransferase inhibiting compounds, cholinesterase inhibiting compounds, monoamine oxidase inhibiting compounds, norepinephrine reuptake inhibiting compounds, selective serotonin reuptake inhibiting compounds, tricyclic antidepressant compounds, serotonin norepinephrine reuptake inhibiting compounds, norepinephrine dopamine reuptake inhibiting compound, noradrenergic and specific serotonergic antidepressants, and combinations thereof.Type: ApplicationFiled: May 7, 2008Publication date: January 22, 2009Inventors: Michael J. Roberts, Simon Pedder
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Publication number: 20090005358Abstract: The invention features methods, compositions, and kits for the treatment of pain or pruritus in a patient. In one embodiment, the methods, compositions, and kits of the invention provide for a combination therapy including a tricyclic compound and a tetra-substituted pyrimidopyrimidine.Type: ApplicationFiled: June 24, 2008Publication date: January 1, 2009Inventor: Jan Lessem
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Publication number: 20090005357Abstract: The present invention relates generally to pharmacological methods for the prevention of amelioration of sleep-related breathing disorders via administration of agents or combinations of agents that possess serotonin-related pharmacological activity.Type: ApplicationFiled: September 11, 2008Publication date: January 1, 2009Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOISInventors: Miodrag Radulovacki, David W. Carley
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Publication number: 20080317883Abstract: The present invention is a method for the treatment of depression comprising administering to a subject in need thereof a therapeutically effective amount of one or more carbamate compounds of Formula 1 and/or Formula 2 as herein defined and shown below for the treatment of depression. The present invention is directed to a method for the treatment of depression, which includes mono-therapy and alternatively, co-therapy with at least one additional antidepressant.Type: ApplicationFiled: October 22, 2007Publication date: December 25, 2008Inventors: Yong Moon Choi, Robert Gordon, Magali Haas, Ewa Malatynska
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Publication number: 20080311176Abstract: The present invention provides novel condensation aerosols for the treatment of disease and/or intermittent or acute conditions. These condensation aerosols have little or no pyrolysis degradation products and are characterized by having an MMAD of between 1-3 microns. These aerosols are made by rapidly heating a substrate coated with a thin film of drug having a thickness of between 0.05 and 20 ?m, while passing a gas over the film, to form particles of a desirable particle size for inhalation. Kits comprising a drug and a device for producing a condensation aerosol are also provided. The device contained in the kit typically, has an element for heating the drug which is coated as a film on the substrate and contains a therapeutically effective dose of a drug when the drug is administered in aerosol form, and an element allowing the vapor to cool to form an aerosol. Also disclosed, are methods for using these aerosols and kits.Type: ApplicationFiled: May 8, 2008Publication date: December 18, 2008Applicant: ALEXZA PHARMACEUTICALS, INC.Inventors: Ron L. Hale, Craig C. Hodges, Peter M. Lloyd, Amy T. Lu, Daniel J. Myers, Joshua D. Rabinowitz, Martin J. Wensley, Jeffrey A. McKinney, Alejandro C. Zaffaroni
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Publication number: 20080306043Abstract: The invention relates to the use of sabcomeline or a pharmaceutically acceptable salt thereof in monotherapy for the treatment of bipolar disorder or mania or and to adjunctive and simultaneous combination therapies for the treatment of bipolar disorder or mania in which sabcomeline or a pharmaceutically acceptable salt thereof and at least one other mood stabilizing or antimanic agent are administered adjunctively or simultaneously. The invention provides methods of treatment of bipolar disorder or mania utilizing such monotherapy and such adjunctive or simultaneous therapeutic combination therapies, therapeutic combinations for use therein and pharmaceutical compositions comprising them.Type: ApplicationFiled: December 23, 2005Publication date: December 11, 2008Inventors: Carol Routledge, James Joseph Hagan, Stuart Paul Cuffe
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Publication number: 20080305140Abstract: The present invention provides a method, a kit and compositions for long-term release of a drug at a constant therapeutically effective level for nervous system disorders where adherence to therapeutic regimen is problematic. In particular, to the therapy of psychotic disorders.Type: ApplicationFiled: January 12, 2005Publication date: December 11, 2008Applicant: UNIVERSITY OF PENNSYLVANIAInventors: Steven Siegel, Karen Winey
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Publication number: 20080299197Abstract: This invention pertains to a multi-layered tablet for a triple combination release of active agents to an environment of use. More particularly, the invention pertains to a multi-layered tablet (1) comprising two external drug-containing layers (2 and 3) in stacked arrangement with respect to and on opposite sides of an oral dosage form (4) that provides a triple combination release of at least one active agent. In one embodiment of the invention the dosage form is an osmotic device. In another embodiment of the invention the dosage form is a gastro-resistant coated core. In yet another embodiment of the invention the dosage form is a matrix tablet. In a different embodiment the dosage form is a hard capsule.Type: ApplicationFiled: June 18, 2008Publication date: December 4, 2008Applicant: OSMOTICA CORP.Inventors: Fernando G. Toneguzzo, Glenn A. Meyer, Marcelo A. Ricci, Marcelo A. Coppari, Ana C. Pastini, Gustavo A. Fischbein
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Publication number: 20080287418Abstract: Extended release formulations of quetiapine and its pharmaceutically salts, and methods for manufacture of the formulations, may include the use of polymers selected for their physical and chemical characteristics. The formulations may include polymers selected to cause solid dosage forms of the formulations to conform to preselected quetiapine release criteria. The formulations may include non-polymer materials that may affect quetiapine release.Type: ApplicationFiled: November 14, 2007Publication date: November 20, 2008Applicant: ASTRAZENECA ABInventors: Daniel Brown, Donna Caster, Brian Clark, Sandra Hopkins, Jennifer Llewelyn, Elizabeth Meehan, Lisa Martin, Robert Timko, Husheng Yang
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Publication number: 20080268043Abstract: The invention relates to a formulation for the treatment of acute manic episodes associated with Bipolar I Disorder comprising an antipsychotic agent selected from the group consisting of: a dibenzothiazepine derivative; lithium; and divalproex. The formulation comprises a first component which comprises a first population the antipsychotic agent and at least one subsequent component which comprises a subsequent population of the antipsychotic agent and which allows for the modified release of the agent. The combination of the first and the subsequent components in operation deliver the antipsychotic agent in a pulsed or controlled manner over a period of up to twenty-four hours.Type: ApplicationFiled: January 26, 2006Publication date: October 30, 2008Applicant: ELAN PHARMA INTERNATIONAL LIMITEDInventors: Scott A Jenkins, Gary Liversidge
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Publication number: 20080255088Abstract: The present invention relates to 11-(piperazin-1-yl)dibenzo[b,f][1,4]oxazapine compounds of the formula: where the variables are as defined herein, their salts and pharmaceutically acceptable compositions thereof. Methods of preparing these compounds are also described. These compounds may be used in the treatment of disorders such as schizophrenia, treatment resistant schizophrenia, bipolar disorder, psychotic depression, treatment resistant depression, schizophrenia-associated depression, treatment resistant OCD, autism, senile psychosis, psychotic dementia, L-DOPA induced psychosis, psychogenic polydipsia, psychotic symptoms of neurological disorders, sleep disorders.Type: ApplicationFiled: March 13, 2008Publication date: October 16, 2008Inventors: Cyrus Becker, Courtney Rubens, Jason Adams, Monica Palme, Pascal Druzgala