Additional Nitrogen Containing Hetero Ring Attached Directly Or Indirectly To The Seven-membered Hetero Ring By Nonionic Bonding Patents (Class 514/211.15)
Abstract: The present invention relates to the use of quinolone carboxylic acid formulations in the treatment of ocular and periocular infections. The present invention also relates to sustained release compositions comprising specific quinolone carboxylic acid compounds. The invention also relates to quinolone carboxylic acid compositions and methods of preparing the same.
Abstract: Cyclic oxyguanidine pyrazinone compounds are described, including compounds of the Formula I:
wherein R3, R4, R5, W, and A are as set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof. The compounds of the invention are potent inhibitors of proteases, especially trypsin-like serine proteases, such as chymotrypsin, trypsin, thrombin, plasmin and factor Xa. Certain of the compounds exhibit antithrombotic activity via direct, selective inhibition of thrombin. Compositions for inhibiting loss of blood platelets, inhibiting formation of blood platelet aggregates, inhibiting formation of fibrin, inhibiting thrombus formation, and inhibiting embolus formation are described.
Type:
Grant
Filed:
July 17, 2001
Date of Patent:
November 5, 2002
Assignee:
3-Dimensional Pharmaceuticals, Inc.
Inventors:
Aihua Wang, Bruce Edward Tomczuk, Tianbao Lu, Richard M. Soll, John Curtis Spurlino, Roger Francis Bone
Abstract: Compounds of formula I
wherein
W is optionally substituted alkylene;
Y is N or CRa;
Ra is hydrogen, halogen or alkyl;
R1n represents hydrogen or 1 to 4 substituents;
R2 is hydrogen, nitro, cyano, halogen, alkyl, haloalkyl, alkoxy, alkylthio or alkoxycarbonyl;
R3 is optionally substituted alkyl, cycloalkyl, aryl or hetaryl;
A is N—OR4, CH—OR4, CH—SR4 or CHR5;
R4 is alkyl or haloalkyl;
R5 is halogen, alkyl or haloalkyl;
methods and intermediates for their preparation. The compounds and compositions comprising them are useful for combating animal pests and harmful fungi.
Type:
Grant
Filed:
July 11, 2001
Date of Patent:
September 17, 2002
Assignee:
BASF Aktiengesellschaft
Inventors:
Markus Gewehr, Hubert Sauter, Bernd Müller, Wassilios Grammenos, Andreas Gypser, Arne Ptock, Oliver Cullmann, Jordi Tormo i Blasco, Eberhard Ammermann, Siegfried Strathmann, Gisela Lorenz, Volker Harries, Roland Götz, Thomas Grote
Abstract: The present invention is substituted amines of formula (X) 1
Type:
Application
Filed:
June 29, 2001
Publication date:
September 12, 2002
Inventors:
James P. Beck, Lawrence Y. Fang, John N. Freskos, Andrea Gailunas, Roy Hom, Barbara Jagodzinska, Varghese John, Michel Maillard, Shon R. Pulley, Ruth E. TenBrink
Abstract: Novel hydroxamic acid compounds are disclosed. These hydroxamates inhibit peptide deformylase (PDF), an enzyme present in prokaryotes and are therefore useful as antimicrobials and antibiotics. Methods of synthesis and of use of the compounds are also disclosed.
Type:
Application
Filed:
December 13, 2000
Publication date:
August 29, 2002
Inventors:
Jeffrey W. Jacobs, Dinesh Patel, Jason Lewis, Zhi-Jie Ni
Abstract: The invention relates to dihydropyrimidines of the general formula
and to the use of dihydropyrimidines as medicaments for the treatment and prophylaxis of hepatitis B. The invention further relates to a process for the preparation of medicaments comprising the corresponding dihydropyrimidines.
Type:
Grant
Filed:
October 18, 2000
Date of Patent:
August 20, 2002
Assignee:
Bayer Aktiengesellschaft
Inventors:
Jürgen Stoltefuss, Siegfried Goldmann, Arnold Paessens, Erwin Graef, Stefan Lottmann
Abstract: The invention provides the use in combating fungi of compounds of general formula (I) wherein R1 is hydrogen, hydroxy, acyl, acyloxy, optionally substituted amino, Ra, Ra3Si, RaS or RaO, where Ra is optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted aryl or optionally substituted heterocyclyl; R2 has the same meaning as Ra or can be hydrogen; Z is oxygen or sulfur, M is a thiophene ring, and R3 and R4, which may be the same or different, have the same meaning as Ra or can be optionally substituted amino, hydrogen, halogen, cyano, nitro or a group ORc or S(O)mRc, where Rc has the same meaning as Ra or is hydrogen or acyl and m is 0, 1 or 2; or R3 and R4 together with the atoms to which they are attached form an optionally substituted carbocyclic or heterocyclic ring; together with tautomers of compounds where R1 is hydrogen.
Type:
Grant
Filed:
November 5, 1999
Date of Patent:
August 13, 2002
Assignee:
Agrevo UK Limited
Inventors:
John Frederick Atherall, Thomas Lawley Hough, Stephen David Lindell, Mary Josephine O'Mahony, John Henry Parsons, Elizabeth Anne Saville-Stones
Abstract: There is provided a pharmaceutical composition suitable for topical administration to an eye, the composition comprising as active agent at least one oxazolidinone antibacterial drug, for example linezolid, in a concentration effective for treatment and/or prophylaxis of a gram-positive bacterial infection of an eye, and at least one ophthalmically acceptable excipient ingredient that reduces a rate of removal of the composition from the eye by lacrimation such that the composition has an effective residence time in the eye of about 2 to about 24 hours. The composition is, for example, an in situ gellable solution, suspension or solution/suspension.
Type:
Application
Filed:
October 10, 2001
Publication date:
August 8, 2002
Inventors:
Rebanta Bandyopadhyay, Pamela J. Secreast, Leslie C. Hawley, Vincent E. McCurdy, Praveen Tyle, Paramita Bandyopadhyay, Satish Kumar Singh
Abstract: The present invention relates to cyclized amide derivatives for treating or preventing neuronal damage associated with neurological diseases. The invention also provides compositions comprising the compounds of the present invention and methods of utilizing those compositions for treating or preventing neuronal damage.
Type:
Application
Filed:
January 3, 2002
Publication date:
August 8, 2002
Inventors:
David Lauffer, Michael Mullican, Brian Ledford
Abstract: Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
Type:
Application
Filed:
February 28, 2001
Publication date:
July 11, 2002
Inventors:
Bing-Yan Zhu, Zhaozhong Jon Jia, Wenrong Huang, Yonghong Song, James Kanter, Robert M. Scarborough
Abstract: This invention relates a to a series of heterocyclic substituted piperazines of Formula I
pharmaceutical compositions containing them and intermediates used in their manufacture. The compounds of the invention selectively inhibit binding to the &agr;-1a adrenergic receptor, a receptor which has been implicated in benign prostatic hyperplasia. As such the compounds are potentially useful in the treatment of this disease.
Type:
Grant
Filed:
October 9, 1998
Date of Patent:
May 7, 2002
Assignee:
Ortho-McNeil Pharmaceutical, Inc.
Inventors:
Richard H. Hutchings, Haripada Khatuya, Gee-Hong Kuo, Xiaobing Li, William V. Murray, Catherine Prouty, Frank Villani, Nelson C. F. Yim, Cynthia Maryanoff
Abstract: This invention relates to urea compounds that are muscarinic receptor antagonists and agonists, pharmaceutical compositions comprising such compounds, and methods of preparing these compounds.
Abstract: The present invention relates to substituted benzothiazole derivitives and to their pharmaceutically acceptable salts useful for the treatment of diseases related to the adenosine receptor.
Type:
Application
Filed:
June 14, 2001
Publication date:
April 18, 2002
Inventors:
Alexander Alanine, Alexander Flohr, Aubry Kern Miller, Roger David Norcross, Claus Riemer
Abstract: Disclosed are methods of treating rheumatoid arthritis by coadministering synergistic effective amounts of pentostatin and methotrexate to a host in need thereof, and kits and compositions that include pentostatin and methotrexate.
Abstract: Compounds of formula I
are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in whose course an increased activity of NF&kgr;B is involved.
Type:
Grant
Filed:
June 22, 2000
Date of Patent:
March 19, 2002
Assignee:
Aventis Pharma Deutschland GmbH
Inventors:
Olaf Ritzeler, Hans Ulrich Stilz, Bernhard Neises, William Jerome Bock, Jr., Armin Walser, Gary A. Flynn, Jörg Habermann, Gerhard Jähne
Abstract: A method of promoting neuronal survival and helping prevent neuronal death administers (di-substituted-phenyl) pyrimidinyl imidazole derivative compounds represented by 1
Type:
Application
Filed:
September 17, 2001
Publication date:
March 14, 2002
Inventors:
Philip LoGrasso, JeanMarie Lisnock-Geissler, Steven Xanthoudakis, John Tam, Sarah J. Harper, James G. Bilsland, Lisa Young
Abstract: The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
Type:
Application
Filed:
March 16, 2001
Publication date:
January 24, 2002
Inventors:
Francesco Salituro, Guy Bemis, Huai Gao, Ghotas Evindar
Abstract: The present application relates to novel acylated 4-amino-pyridine derivatives
in which
R1, R2, R3, R4, A, X1, X2, m and n are as defined in the description,
to process for their separation and to their use for controlling animal pests and as fungicides.
Type:
Grant
Filed:
May 9, 2000
Date of Patent:
January 1, 2002
Assignee:
Bayer Aktiengesellschaft
Inventors:
Thomas Bretschneider, Markus Heil, Bernd Alig, Gerd Kleefeld, Christoph Erdelen, Andreas Turberg, Norbert Mencke
Abstract: One aspect of the present invention relates to novel heterocyclic compounds comprising urea functionality. A second aspect of the present invention relates to the use of the novel heterocyclic compounds comprising urea functionality as ligands for various cellular receptors, including opioid receptors, other G-protein-coupled receptors and ion channels. An additional aspect of the present invention relates to the use of the novel heterocyclic compounds comprising urea functionality as analgesics.
Type:
Application
Filed:
February 23, 2001
Publication date:
December 27, 2001
Inventors:
Brian M. Aquila, Gregory D. Cuny, James R. Hauske, Liming Shao, Xinhe Wu
Abstract: The present invention relates to a novel pyrimidinone compounds and the pharmaceutical acceptable salts thereof having remarkable antagonistic action against angiotensin II receptor, thereby, being useful in treating cardiovascular disease caused by binding angiotensin II to its receptor.
Type:
Grant
Filed:
December 20, 1999
Date of Patent:
September 25, 2001
Assignee:
Boryung Pharmaceutical Co. Ltd.
Inventors:
Jae-hyoung Lee, Kyung-jin Jang, Byoung-wug Yoo, Ji-han Kim, Jae-seog Kang, Sang-lin Kim
Abstract: Compounds of the formula (I):
where X1, A, Ar1, X and R are as defined in the specification, and pharmaceutically-acceptable salts thereof, are new, and are useful as tachykinin inhibitors which act at the NK1, NK2 and NK3 receptors or a combination of two or more thereof.
Type:
Grant
Filed:
November 10, 1999
Date of Patent:
July 17, 2001
Assignee:
Pfizer Inc.
Inventors:
David Alker, Thomas Victor Magee, Graham Nigel Maw, Donald Stuart Middleton