Plural Cyclos Of The Polycyclo Ring System Share Ring Nitrogen Of The Seven-membered Hetero Ring Patents (Class 514/212.05)
  • Particle-forming compositions containing fused pyrrolocarbazoles
    Patent number: 6200968
    Abstract: A non-aqueous, particle-forming, fused pyrrolocarbazole-containing composition is disclosed. Upon contact with an aqueous medium, the particle-forming composition spontaneously disperses into suspended particles, thereby forming a stable suspension that provides greatly improved bioavailability of orally administered fused pyrrolocarbazole compounds.
    Type: Grant
    Filed: August 5, 1999
    Date of Patent: March 13, 2001
    Assignee: Cephalon, Inc.
    Inventors: David A. Dickason, Piyush R. Patel, Vincent Corvari, Efraim Shek, Joseph L. Herman, Jeffry M. Skell
  • Enhancement of return to independent living status with a growth hormone secretagogue
    Patent number: 6194402
    Abstract: A growth hormone secretagogue is useful for enhancing the return of patients to independent living status following acute deconditioning such as that which may result from immobilization, surgery, or major injury such as hip fracture.
    Type: Grant
    Filed: August 31, 1999
    Date of Patent: February 27, 2001
    Assignee: Merck & Co., Inc.
    Inventors: Mark Bach, Vivian Fuh, Jennifer Ng, Alice Taylor
  • Tricyclic compounds for the inhibition of the ICE/ced-3 protease family of enzymes
    Patent number: 6187771
    Abstract: This invention is directed to novel tricyclic ICE/ced-3 family inhibitor compounds. The invention is also directed to pharmaceutical compositions of such tricyclic compounds, plus the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, and for the prevention of ischemic injury.
    Type: Grant
    Filed: June 23, 1999
    Date of Patent: February 13, 2001
    Assignee: Idun Pharmaceuticals, Inc.
    Inventors: Donald S. Karanewsky, Steven D. Linton