Bicyclo Ring System Having The Seven-membered Hetero Ring As One Of The Cyclos Patents (Class 514/212.07)
  • Substituted lactams as inhibitors of A beta protein production
    Publication number: 20020025955
    Abstract: This invention relates to novel lactams of Formula (I): 1
    Type: Application
    Filed: April 11, 2001
    Publication date: February 28, 2002
    Inventors: Qi Han, Hong Liu, Richard E. Olson, Michael G. Yang
  • 5-HT4 receptor antagonists
    Publication number: 20020019386
    Abstract: Compounds of formula (I) and pharmaceutically acceptable salts thereof, and the use of a compound of formula (I) or a pharmaceutically acceptable salt thereof:
    Type: Application
    Filed: August 27, 2001
    Publication date: February 14, 2002
    Applicant: SmithKline Beecham p.l.c.
    Inventors: Francis David King, Laramie Mary Gaster, Keith Raymond Mulholland
  • Vitronectin receptor antagonist
    Publication number: 20020019387
    Abstract: A compound of the formula (I) is disclosed which is a vitronectin receptor antagonist and is useful in the treatment of osteoporosis: 1
    Type: Application
    Filed: September 20, 2001
    Publication date: February 14, 2002
    Applicant: SmithKline Beecham Corporation
    Inventor: William E. Bondinell
  • Vitronectin receptor antagonist
    Publication number: 20010014737
    Abstract: A compound of the formula (I) is disclosed which is a vitronectin receptor antagonist and is useful in the treatment of osteoporosis: 1
    Type: Application
    Filed: March 5, 2001
    Publication date: August 16, 2001
    Inventor: Dirk Heerding
  • Bezazepine derivatives as &agr;v integrin receptor antagonists
    Patent number: 6232308
    Abstract: The present invention relates to benzazepine derivatives and their use as &agr;v integrin receptor antagonists. More particularly, the compounds of the present invention are antagonists of the integrin receptors &agr;v&bgr;3, &agr;v&bgr;5, and/or &agr;v&bgr;6 and are useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting vascular restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation, wound healing, viral disease, tumor growth, and metastasis.
    Type: Grant
    Filed: February 2, 2000
    Date of Patent: May 15, 2001
    Assignee: Merck & Co., Inc.
    Inventor: Ben C. Askew
  • Selective factor Xa inhibitors
    Patent number: 6228854
    Abstract: Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.
    Type: Grant
    Filed: August 11, 1998
    Date of Patent: May 8, 2001
    Assignee: Cor Therapeutics, Inc.
    Inventors: Robert Scarborough, Bing-Yan Zhu
  • Selective factor Xa inhibitors
    Patent number: 6218382
    Abstract: Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are usefull in vitro or in vivo for preventing or treating coagulation disorders.
    Type: Grant
    Filed: August 11, 1998
    Date of Patent: April 17, 2001
    Assignee: COR Therapeutics, INC
    Inventors: Bing-Yan Zhu, Robert Scarborough
  • Vitronectin receptor antagonists, their preparation and use
    Patent number: 6207663
    Abstract: Vitronectin receptor antagonists, their preparation and their use The present invention relates to compounds of the formula I A—B—D—E—F—G   (I) in which A, B, D, E, F and G have the meanings given in the patent claims, to their preparation and to their use as medicaments. The compounds of the invention are used as vitronectin receptor antagonists and as inhibitors of bone resorption.
    Type: Grant
    Filed: October 5, 1999
    Date of Patent: March 27, 2001
    Assignees: Hoechst Atkiengesellschaft, Genentech, Inc.
    Inventors: Volkmar Wehner, Hans Ulrich Stilz, Anuschirwan Peyman, Jochen Knolle, Jean-Marie Ruxer, Denis Carniato, Jean-Michel LeFrancois, Thomas Richard Gadek, Robert McDowell