Hetero Ring Is Six-membered Consisting Of Three Nitrogens And Three Carbon Atoms Patents (Class 514/241)
Asymmetrical (e.g., 1,2,4-triazine, etc.) (Class 514/242)
Hexamethylenetetramines (Class 514/244)
Nitrogen bonded directly to ring carbon of the hetero ring (Class 514/245)
Polycyclo ring system having a 1,3,5-triazine as one of the cyclos (Class 514/246)
  • Vehicle for applying chemical compounds on wood
    Publication number: 20030162781
    Abstract: A vehicle for applying chemical compounds to wood comprises the following components in the indicated approximate percentages by weight of the total: toluene (40-70%), xylene (6-40%), benzophenone (3-18%), butyl glycol (2-9%), cetyl acetate (1-7%) and methanol (0.3-4%). The vehicle has a high wood penetration index and can be used for preparing compositions containing one or more chemical compounds useful for treating wood, for example insecticides and/or fungicides, for the purpose of treating or preventing damage caused by the attack of biological agents harmful for wood.
    Type: Application
    Filed: February 21, 2003
    Publication date: August 28, 2003
    Inventor: Rafael Rodriguez Ramos
  • Carboxylic acid derivatives, their production and use
    Patent number: 6610691
    Abstract: The invention relates to carboxylic acid derivatives of the formula where the radicals have the meanings defined in the description, to the preparation of these compounds and to their use as drugs.
    Type: Grant
    Filed: October 8, 1998
    Date of Patent: August 26, 2003
    Assignee: BASF Aktiengesellschaft
    Inventors: Hartmut Riechers, Dagmar Klinge, Wilhelm Amberg, Andreas Kling, Heinz Hillen, Liliane Unger, Bernd Elger
  • Fused azabicyclic compounds that inhibit vanilloid receptor subtype 1 (VR1) receptor
    Publication number: 20030158198
    Abstract: Compound of formula (I) 1
    Type: Application
    Filed: February 11, 2003
    Publication date: August 21, 2003
    Inventors: Chih-Hung Lee, Erol K. Bayburt, Stanley DiDomenico, Irene Drizin, Arthur R. Gomtsyan, John R. Koenig, Richard J. Perner, Robert G. Schmidt, Sean C. Turner, Tammie K. White, Guo Zhu Zheng
  • Certain alkylene diamine-substituted heterocycles
    Publication number: 20030158197
    Abstract: The present invention also provides a general method to whereby mono-, bi-, or tricyclic heterocycles may be modified to obtain potent antagonists at the NPY1 receptor.
    Type: Application
    Filed: November 8, 2002
    Publication date: August 21, 2003
    Applicant: NEUROGEN CORPORATION
    Inventors: Raymond F. Horvath, Jennifer N. Tran, Stephane De Lombaert, Kevin J. Hodgetts, Philip A. Carpino, David A. Griffith
  • Bisaryl compound and medicament for cancer treatment comprising the same
    Patent number: 6608061
    Abstract: A medicament for treatment of cancer comprising a compound represented by the following general formula (I) or a physiologically acceptable salt thereof: Ar1—S—R1—S—Ar2 wherein R1 represents a nonmetal bridging group; Ar1 and Ar2 independently represent a group selected from the group consisting of an aryl group which has, on its ring, one to three hydroxyl groups optionally substituted with a monovalent group and said aryl group may have one to three substituents other than hydroxyl group on its ring; and a heteroaryl group which has, on its ring, one to three hydroxyl groups optionally substituted with a monovalent group, and said heteroaryl group may have one to three substituents other than hydroxyl group on its ring.
    Type: Grant
    Filed: February 14, 2000
    Date of Patent: August 19, 2003
    Assignees: Kyoma Hakko Kogyo Co., Ltd., Fuji Photo Film Co., Ltd.
    Inventors: Yoshiyuki Yonetani, Takeshi Takahashi, Yuko Kanda, Tamio Mizukami, Tatsuya Tamaoki, Shun-ichi Ikeda, Masanobu Takashima, Naoki Asanuma, Tadashi Inaba, Hiroshi Takeuchi, Hiroshi Kawamoto, Yoshihisa Tsukada, Masato Satomura, Hiroshi Kitaguchi
  • Benzothiazole derivatives
    Publication number: 20030153568
    Abstract: The present invention is directed to a compound of formula (I), 1
    Type: Application
    Filed: February 6, 2001
    Publication date: August 14, 2003
    Applicant: BASF Aktiengesellschaft Ludwigshafen, Germany
    Inventors: Kevin P. Cusack, Barbara Scott, Lee D. Arnold, Anna M. Ericsson
  • Novel pyrazole and pyrazoline substituted compounds
    Publication number: 20030153569
    Abstract: Novel pyridyl and pyrimidinyl substituted pyrazole and pyrazoline compounds and compositions for use in therapy.
    Type: Application
    Filed: February 19, 2003
    Publication date: August 14, 2003
    Applicant: SmithKline Beecham Corporation
    Inventors: Jerry L. Adams, Timothy Gallagher, Irennegbe Kelly Osifo
  • Modulators of peroxisome proliferator activated receptor-gamma, and methods for the use thereof
    Patent number: 6605627
    Abstract: In accordance with the present invention, there is provided a class of compounds which are capable of modulating processes mediated by peroxisome proliferator activated receptor-gamma (PPAR-&ggr;). The identification of such compounds makes it possible to intervene in PPAR-&ggr; mediated pathways.
    Type: Grant
    Filed: May 8, 2002
    Date of Patent: August 12, 2003
    Assignee: The Salk Insitute for Biological Studies
    Inventors: Ronald M. Evans, Barry M. Forman
  • Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants
    Publication number: 20030149040
    Abstract: This invention is directed to poly-hydroxylated monocyclic N-heterocyclic derivatives selected from the following formulae: 1 2
    Type: Application
    Filed: January 24, 2003
    Publication date: August 7, 2003
    Applicant: Berlex Laboratories, Inc.
    Inventor: Gary B. Phillips
  • 5-heteroaryl substituted indoles
    Patent number: 6602889
    Abstract: The present invention relates to compounds having general formula (I) as defined herein, or a pharmaceutically acceptable acid addition salt thereof. The compounds are selective &agr;1-adrenoceptor ligands.
    Type: Grant
    Filed: September 28, 2000
    Date of Patent: August 5, 2003
    Assignee: H. Lundbeck A.S.
    Inventors: Jens Kristian Perregaard, Kim Andersen, Thomas Balle
  • Method for treating fibrotic diseases with azolium chroman compounds
    Patent number: 6596745
    Abstract: Provided is a method of treating or ameliorating hypertension in an animal comprising administering an effective amount of a compound of formula I:
    Type: Grant
    Filed: May 30, 2002
    Date of Patent: July 22, 2003
    Assignee: Alteon, Inc.
    Inventor: Martin Gall
  • Synergistic insecticide mixtures
    Publication number: 20030134857
    Abstract: The invention relates to insecticidal mixtures of fipronil and agonists or antagonists of nicotinic acetylcholine receptors for the protection of industrial materials and plants.
    Type: Application
    Filed: January 21, 2003
    Publication date: July 17, 2003
    Inventors: Hermann Uhr, Hans-Ulrich Buschhaus, Martin Kugler, Franz Kunisch, Heinrich Schrage
  • Method of treating colonic adenomas
    Patent number: 6593361
    Abstract: This invention is directed to a method of retarding or preventing the transformation of a colonic adenoma to a colonic adenocarcinoma comprising the administration to a patient with FAP or a patient with one or more of said adenomas a non-toxic therapeutically effective amount of NSAID, said amount effective to inhibit the PGHS-2 in said adenoma. The preferred method comprises the administration of a specific PGHS-2 inhibiting agent as defined herein.
    Type: Grant
    Filed: October 12, 2001
    Date of Patent: July 15, 2003
    Inventors: Stacia Kargman, Jilly Evans, Thomas J. Simon
  • Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
    Publication number: 20030130282
    Abstract: GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women.
    Type: Application
    Filed: August 2, 2002
    Publication date: July 10, 2003
    Applicant: Neurocrine Biosciences, Inc.
    Inventors: Zhiqiang Guo, Dongpei Wu, Chen Chen, Fabio Tucci, Collin Regan
  • Isoxazolo [4,5-d] pyrimidines as CRF antagonists
    Patent number: 6589958
    Abstract: The present invention describes novel isoxazolo[1,5-a]pyrimidines of formula: wherein R is an aromatic or heteroaromatic ring, or pharmaceutically acceptable salt form thereof, which are useful as CRF antagonists.
    Type: Grant
    Filed: March 27, 2002
    Date of Patent: July 8, 2003
    Assignee: Bristol-Myers Squibb Pharma Company
    Inventor: William Eric Frietze
  • Phthalazine derivatives as phosphodiesterase 4 inhibitors
    Patent number: 6589951
    Abstract: Compounds of formula (I) wherein B is alkylene, amino, CONH or a bond; Cy is optionally substituted phenyl or heteroaryl; R is H, phenyl or (C1-4)alkyl optionally substituted; R1 is (C1-6)alkyl or polyfluoro(C1-6)-alkyl; R2 is (C4-7)cycloalkyl optionally containing an oxygen atom and optionally substituted; and the N→O derivatives and pharmaceutically acceptable salt thereof are PDE 4 and TNF&agr; inhibitors.
    Type: Grant
    Filed: August 10, 2000
    Date of Patent: July 8, 2003
    Assignee: Zambon Group S.p.A.
    Inventors: Mauro Napoletano, Gabriele Norcini, Daniela Botta, Giancarlo Grancini, Gabriele Morazzoni, Francesco Santangelo, Jorge G. Siro Herrero, José Luis Garcia Navaio, Julio G. Alvarez-Builla
  • Substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity
    Publication number: 20030125329
    Abstract: The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases.
    Type: Application
    Filed: May 23, 2002
    Publication date: July 3, 2003
    Applicant: G.D. Searle & Co.
    Inventors: James A. Sikorski, Richard C. Durley, Deborah A. Mischke, Emily J. Reinhard, Yvette M. Fobian, Michael B. Tollefson, Lijuan Wang, Margaret L. Grapperhaus, Brian S. Hickory, Mark A. Massa, Monica B. Norton, William F. Vernier, Barry L. Parnas, Michele A. Promo, Ashton T. Hamme, Dale P. Spangler, Melvin L. Rueppel
  • Substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity
    Publication number: 20030125328
    Abstract: The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases.
    Type: Application
    Filed: May 23, 2002
    Publication date: July 3, 2003
    Applicant: G.D. Searle & Co.
    Inventors: James A. Sikorski, Richard C. Durley, Deborah A. Mischke, Emily J. Reinhard, Yvette M. Fobian, Michael B. Tollefson, Lijuan Wang, Margaret L. Grapperhaus, Brian S. Hickory, Mark A. Massa, Monica B. Norton, William F. Vernier, Barry L. Parnas, Michele A. Promo, Ashton T. Hamme, Dale P. Spangler, Melvin L. Rueppel
  • Probes, systems, and methods for drug discovery
    Publication number: 20030125315
    Abstract: Aspects of the present invention include probes, methods, systems that have stand alone utility and may comprise features of a drug discovery system or method. The present invention also includes pharmaceutical compositions.
    Type: Application
    Filed: April 11, 2002
    Publication date: July 3, 2003
    Inventors: Adnan M. M. Mjalli, Chris Wysong, Jerome Baudry, Thomas Scott Yokum, Rob Andrews, William K. Banner
  • Tricyclic fused xanthine compounds and their uses
    Patent number: 6586429
    Abstract: Novel tricyclic compounds are found to be useful for the treatment or prevention of symptoms or manifestations associated with diseases or disorders affected by cytokine intracellular signaling. The compounds have the following formulas where R1, R2 and R3 are defined in the written description of the invention.
    Type: Grant
    Filed: November 29, 2000
    Date of Patent: July 1, 2003
    Assignee: Cell Therapeutics, Inc.
    Inventors: Baoqing Gong, J. Peter Klein, Michael Coon
  • Substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity
    Publication number: 20030119833
    Abstract: The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases.
    Type: Application
    Filed: May 23, 2002
    Publication date: June 26, 2003
    Applicant: G.D. Searle & Co.
    Inventors: James A. Sikorski, Richard C. Durley, Deborah A. Mischke, Emily J. Reinhard, Yvette M. Fobian, Michael B. Tollefson, Lijuan Wang, Margaret L. Grapperhaus, Brian S. Hickory, Mark A. Massa, Monica B. Norton, William F. Vernier, Barry L. Parnas, Michele A. Promo, Ashton T. Hamme, Dale P. Spangler, Melvin L. Rueppel
  • Compositions and methods of treatment of cancer
    Publication number: 20030119834
    Abstract: The present invention generally relates to compositions useful in the treatment or prevention of cancer, in some cases by limiting or preventing angiogenesis. Other compositions useful for the treatment or prevention of cancer or angiogenesis include homologs, analogs, derivatives, enantiomers or functionally equivalent compositions of the present invention. The present compositions can be packaged in kits. The present invention also relates to the use of compositions useful for the treatment of patients susceptible to or exhibiting symptoms characteristic of cancer, for example, patients with solid tumors.
    Type: Application
    Filed: September 5, 2002
    Publication date: June 26, 2003
    Inventor: Cynthia C. Bamdad
  • Polymorphic form of a tachykinin receptor antagonist
    Patent number: 6583142
    Abstract: This invention is concerned with a novel polymorphic form of the compound 2-(R)-(1-(R)-(3,5-bis(trifluoromethyl)-phenyl)-ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methylmorpholine which is a tachykinin receptor antagonist useful in the treatment or prevention of disorders of the central nervous system, inflammatory diseases, pain or migraine, asthma, and emesis. The instant polymorphic form has advantages over the other known forms of 2-(R)-(1-(R)-(3,5-bis(trifluoro-methyl)-phenyl)ethoxy)-3-(S)-(4-fluoro)phenyl-4-(3-(5-oxo-1H,4H-1,2,4-triazolo)methylmorpholine in terms of thermodynamic stability and suitability for inclusion in pharmaceutical formulations.
    Type: Grant
    Filed: August 12, 2002
    Date of Patent: June 24, 2003
    Assignee: Merck & Co.
    Inventors: Louis Crocker, James McCauley
  • Dermal barrier composition
    Patent number: 6582683
    Abstract: Disclosed is a dermal barrier composition which contains a hydrophilic polymer emulsion and a hydrophobic polymer emulsion. The dermal barrier composition is moisture activated, and remains inert until the hydrophobic and hydrophilic polymer emulsions contact a suitable substrate such as human skin. The dermal barrier composition is itself an emulsion, and can optionally contain a biocidal agent for antimicrobial and antiviral efficacy. The dermal barrier composition can also contain other active agents such as sunscreens, insect repellents and fungicides. The dermal barrier composition can be applied topically to skin, where it forms a protective or barrier layer against a number of pathogenic and chemical irritants.
    Type: Grant
    Filed: January 4, 2000
    Date of Patent: June 24, 2003
    Assignee: Skinvisible Pharmaceuticals, Inc.
    Inventor: Bruce Jezior
  • Novel substituted imidazole compounds
    Publication number: 20030114452
    Abstract: Novel 1,4,5-substituted imidazole compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors.
    Type: Application
    Filed: May 17, 2002
    Publication date: June 19, 2003
    Applicant: SmithKline Beecham Corporation
    Inventors: Jerry L. Adams, Ralph F. Hall
  • Isoxazolo [4,5-d] pyrimidines as CRF antagonists
    Publication number: 20030114451
    Abstract: The present invention describes novel isoxazolo[1,5-a]pyrimidines of formula: 1
    Type: Application
    Filed: March 27, 2002
    Publication date: June 19, 2003
    Inventor: William Eric Frietze
  • Aryl and heteroaryl substituted tetrahydroisoquinolines and use thereof
    Patent number: 6579885
    Abstract: Provided herein are compounds of the formula (I): wherein R1-R8 are as described herein, R4 being aryl or heteroaryl Such compounds are particularly useful in the treatment of a disorder which is created by or is dependent upon decreased availability of serotonin, norepinephrine or dopamine.
    Type: Grant
    Filed: March 6, 2002
    Date of Patent: June 17, 2003
    Assignee: Albany Molecular Research, Inc.
    Inventors: James P. Beck, Matt A. Curry, Mark A. Smith
  • Use of s-triazines for treating Apicomplexan parasitic infections
    Publication number: 20030109529
    Abstract: This invention relates to novel compositions and methods of treating humans and animals infected by Apicomplexan parasites. More specifically, the present invention relates to treating an Apicomplexan infection by administering s-triazines, such as atrazine, to an infected human or animal. The present invention also relates to pharmaceutical compositions containing therapeutically effective amounts of s-triazines, such as atrazine, useful in treating parasitic infections.
    Type: Application
    Filed: October 2, 2002
    Publication date: June 12, 2003
    Applicant: Biomes, Inc.
    Inventors: Miles P. Hacker, Greg Manske, Lori L. Shatney-Leach
  • Substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity
    Publication number: 20030109528
    Abstract: The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases.
    Type: Application
    Filed: May 23, 2002
    Publication date: June 12, 2003
    Applicant: G.D. Searle & Co.
    Inventors: James A. Sikorski, Richard C. Durley, Deborah A. Mischke, Emily J. Reinhard, Yvette M. Fobian, Michael B. Tollefson, Lijuan Wang, Margaret L. Grapperhaus, Brian S. Hickory, Mark A. Massa, Monica B. Norton, William F. Vernier, Barry L. Parnas, Michele A. Promo, Ashton T. Hamme, Dale P. Spangler, Melvin L. Rueppel
  • Pyrimidinylbenzimidazole and triazinylbenzimidazole derivatives and agricultural/horticultural bactericides
    Patent number: 6576631
    Abstract: A pyrimidinylbenzimidazole or triazinylbenzimidazole derivative represented by the general formula (I): wherein A is N or CR3, and R1, R2, R3, X, Y and n are as defined in the disclosure.
    Type: Grant
    Filed: May 8, 2001
    Date of Patent: June 10, 2003
    Assignees: Kumiai Chemical Industry Co., Ltd., Ihara Chemical Industry Co., Ltd.
    Inventors: Masaru Shibata, Kiyoshi Kawai, Takechi Makihara, Norihisa Yonekura, Takehiro Kawashima, Junetsu Sakai, Norimichi Muramatsu
  • Stable liquid antimicrobial suspension compositions containing quarternaries prepared from hexamethylenetetramine and certain halohydrocarbons
    Patent number: 6576633
    Abstract: Anhydrous, liquid antimicrobial compositions comprising quaternaries 1-(benzyl)-3,5,7-triaza-1-azoniaadamantane chloride, 1-(3-chloroallyl)-3,5,7-triaza-1-azoniaadamantane chloride and the cis- and cis/trans-isomers thereof, 1-(&agr;-(2-xylyl))-3,5,7-triaza-1-azoniaadamantane chloride and methyl 1-(3,5,7-triaza-1-azoniaadamantane chloride) acetate in admixture with an anhydrous carrier liquid and a thixotropic material are substantially stable to color changes, physical changes and/or chemical changes while under conventional storage conditions for extended time periods.
    Type: Grant
    Filed: February 22, 1996
    Date of Patent: June 10, 2003
    Assignee: The Dow Chemical Company
    Inventors: Tracy L. Young, Philip J. Brondsema
  • Substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity
    Publication number: 20030105100
    Abstract: The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases.
    Type: Application
    Filed: May 23, 2002
    Publication date: June 5, 2003
    Applicant: G.D. Searle & Co.
    Inventors: James A. Sikorski, Richard C. Durley, Deborah A. Mischke, Emily J. Reinhard, Yvette M. Fobian, Michael B. Tollefson, Lijuan Wang, Margaret L. Grapperhaus, Brian S. Hickory, Mark A. Massa, Monica B. Norton, William F. Vernier, Barry L. Parnas, Michele A. Promo, Ashton T. Hamme, Dale P. Spangler, Melvin L. Rueppel
  • Substituted 7-aza[2.2.1]bicycloheptanes for the treatment of disease
    Publication number: 20030105089
    Abstract: The invention provides compounds of Formula I: 1
    Type: Application
    Filed: September 4, 2002
    Publication date: June 5, 2003
    Inventors: Donn G. Wishka, Daniel Patrick Walker, Jeffrey W. Corbett, Steven Charles Reitz, Mark R. Rauckhorst, Vincent E. Groppi
  • Composition and antiviral activity of substituted indoleoxoacetic piperazine derivatives
    Patent number: 6573262
    Abstract: The invention comprises substituted indoleoxoacetic piperazine derivatives of general Formula I, compositions thereof and their use as antiviral agents, and particularly for treating HIV infection.
    Type: Grant
    Filed: December 19, 2001
    Date of Patent: June 3, 2003
    Assignee: Bristol-Myers Sqibb Company
    Inventors: Owen B. Wallace, Tao Wang, Kap-Sun Yeung, Bradley C. Pearce, Nicholas A. Meanwell, Zhilei Qiu, Haiquan Fang, Qiufen May Xue, Zhiwei Yin
  • Triazole compounds useful in treating diseases associated with unwanted cytokine activity
    Publication number: 20030100558
    Abstract: The present invention relates to 4-aryl triazoles having the formula: 1
    Type: Application
    Filed: April 24, 2002
    Publication date: May 29, 2003
    Inventors: Joshua Spector Tullis, John Charles Van Rens, Michael Philip Clark, Benjamin Eric Blass, Michael George Natchus, Biswanath De
  • Methods for treatment of disorders of cardiac contractility
    Patent number: 6569862
    Abstract: The present invention relates to methods for modulating calcium sensitivity of cardiac muscle. In preferred aspects, the invention provides methods for enhancing myocardial contractility and cardiac performance, and methods for treatment of heart failure and other disorders associated with cardiac contractility by administration of one or more xanthine oxidase inhibitor compounds.
    Type: Grant
    Filed: October 6, 2000
    Date of Patent: May 27, 2003
    Assignee: Johns Hopkins University
    Inventor: Eduardo Marban
  • Isoxazolone compounds useful in treating diseases associated with unwanted cytokine activity
    Publication number: 20030096814
    Abstract: Isoxazolone compounds having the generic structure: 1
    Type: Application
    Filed: May 7, 2002
    Publication date: May 22, 2003
    Inventors: Michael Philip Clark, Jane Far-Jine Djung, Steven Karl Laughlin, Joshua Spector Tullis, Michael George Natchus, Biswanath De
  • Novel compositions and methods for prevention and treatment of protozoal disease
    Publication number: 20030096815
    Abstract: A composition is provided that has been specially adapted for parenteral administration, e.g., intranasal, intramuscular, subcutaneous, transdermal or intraveneous administration, wherein the composition is comprised of at least one anti-protozoal drug in a therapeutically effective amount for the treatment or prevention of protozoan infections in man an in animals. In one embodiment, the anti-protozoal drug is a triazine-based anticoccidial agent, e.g., a triazinedione or triazinetrione such as diclazuril, toltrazuril, sulfonotoltrazuril or water-soluble sodium salts thereof. In a presently preferred embodiment, the triazine-based anticoccidial agent is sulfonototrazuril. Methods of treatment of protozoal infections in man and animals are also provided.
    Type: Application
    Filed: September 3, 2002
    Publication date: May 22, 2003
    Applicant: New Ace Research Company
    Inventors: Bruce E. Hundley, Robert E. Maclin
  • Method for the treatment of Flaviviridea viral infection using nucleoside analogues
    Patent number: 6566365
    Abstract: In accordance with the present invention there is provided a method for treating or preventing a Flaviviridea viral infection in a host comprising administering a therapeutically effective amount of at least one compound of formula (I) or (II) or a pharmaceutically acceptable salts thereof, wherein Ra, R, Z and Y are defined in the application.
    Type: Grant
    Filed: November 3, 2000
    Date of Patent: May 20, 2003
    Assignee: BioChem Pharma Inc.
    Inventor: Richard Storer
  • Substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity
    Publication number: 20030087905
    Abstract: The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases.
    Type: Application
    Filed: May 23, 2002
    Publication date: May 8, 2003
    Applicant: G.D. Searle & Co.
    Inventors: James A. Sikorski, Richard C. Durley, Deborah A. Mischke, Emily J. Reinhard, Yvette M. Fobian, Michael B. Tollefson, Lijuan Wang, Margaret L. Grapperhaus, Brian S. Hickory, Mark A. Massa, Monica B. Norton, William F. Vernier, Barry L. Parnas, Michele A. Promo, Ashton T. Hamme, Dale P. Spangler, Melvin L. Rueppel
  • Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants
    Patent number: 6559147
    Abstract: This invention is directed to poly-hydroxylated monocyclic N-heterocyclic derivatives selected from the following formulae: wherein Z1, Z2, R1, R2, R3, R4, R5, R6, and R7 are defined herein. These compounds are useful as anti-coagulants.
    Type: Grant
    Filed: May 4, 2001
    Date of Patent: May 6, 2003
    Assignee: Berlex Laboratories, Inc.
    Inventor: Gary B. Phillips
  • Pyrazole compounds useful as protein kinase inhibitors
    Publication number: 20030083327
    Abstract: This invention describes novel pyrazole compositions comprising a pharmaceutically acceptable carrier and a compound of formula VIII: 1
    Type: Application
    Filed: September 14, 2001
    Publication date: May 1, 2003
    Inventors: Robert Davies, Pan Li
  • Substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity
    Publication number: 20030083331
    Abstract: The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases.
    Type: Application
    Filed: May 23, 2002
    Publication date: May 1, 2003
    Applicant: G.D. Searle & Co.
    Inventors: James A. Sikorski, Richard C. Durley, Deborah A. Mischke, Emily J. Reinhard, Yvette M. Fobian, Michael B. Tollefson, Lijuan Wang, Margaret L. Grapperhaus, Brian S. Hickory, Mark A. Massa, Monica B. Norton, William F. Vernier, Barry L. Parnas, Michele A. Promo, Ashton T. Hamme, Dale P. Spangler, Melvin L. Rueppel
  • Nad synthetase inhibitors and uses thereof
    Publication number: 20030083269
    Abstract: Disclosed are compounds that inhibit the microbial NAD synthetase enzyme. For example, disclosed are compounds of the formula Ar1—X—Ar2—Y—L—Z—Q, wherein Q is Q1Ar3 or Ar3Q1; Ar1, Ar2, and Ar3 are independently aryl or heteroaryl, optionally substituted with one or more substituents; X, Y, and Z are independently selected from the group consisting of a covalent bond or groups containing one or more of C, H, N, O, S atoms; L is a linker and Q1 is an alkylenyl, alkylenyl carbonyloxy alkyl, or alkylenyl carbonylamino alkyl group, optionally having a substituent; a covalent bond; a group containing amidine or guanidine function wherein the amidine or guanidine may be optionally N-substituted with an alkyl; or a zwitterion; or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: February 22, 2002
    Publication date: May 1, 2003
    Applicant: Virtual Drug Development, Inc.
    Inventors: Wayne J. Brouillette, Lawrence DeLucas, Christie Brouillette, Sadanandan E. Velu, Yong-Chul Kim, Liyuan Mou, R. Stephen Porter
  • Chemical derivatives and their application as antitelomerase agents
    Publication number: 20030078263
    Abstract: The present invention relates to cancer therapy and to novel anticancer agents having a mechanism of action which inhibits telomerase. It also relates to novel chemical compounds as well as their therapeutic application in humans.
    Type: Application
    Filed: January 9, 2002
    Publication date: April 24, 2003
    Inventors: Patrick Mailliet, Jean-Francois Riou, Marcel Alasia, Thomas Caulfield, Gilles Doerflinger, Jean-Louis Mergny, Abdelazize Laoui, Odile Petitgenet, Emmanuelle Renou
  • Antibiofouling method and apparatus for optical sensors
    Patent number: 6551583
    Abstract: An antibiofouling material, a method for making said antibiofouling material, a sensor apparatus employing said antibiofouling material, and a method of making said sensor apparatus. The disclosed antibiofouling material includes one or more biocides and one or more charge transfer compounds are embedded within a copolymer host matrix. Biocides used in the present invention may include, but are not limited to, Halobenzonitriles, Azoles, diuron; and simazine. Among its uses, the antibiofouling material of the present invention can be used in a sensor apparatus. In a preferred embodiment, one or more surfaces of said sensor apparatus are coated with an antibiofouling material comprised of one or more biocides, one or more charge transfer compounds, and a copolymer host matrix.
    Type: Grant
    Filed: April 25, 2001
    Date of Patent: April 22, 2003
    Assignee: Airak, Inc,
    Inventors: Paul G. Duncan, Sean Michael Christian, David M. Orcutt
  • Synergistic analgesic combination of oxycodone and rofecoxib
    Patent number: 6552031
    Abstract: Disclosed is a pharmaceutical composition, comprising a combination of a dose of rofecoxib or a pharmaceutically acceptable salt thereof and a dose of oxcodone or a pharmaceutically acceptable salt thereof, said combination in an amount sufficient to provide an analgesic effect in a human patient. Also disclosed is a method of effectively treating pain in humans or other mammals, comprising administering to the patient a combination of a dose of rofecoxib or a pharmaceutically acceptable salt thereof and a dose of oxycodone or a pharmaceutically acceptable salt thereof such that the dosing interval of the rofecoxib overlaps with the dosing interval of the oxycodone, said combination in an amount sufficient to provide an analgesic effect in a human patient.
    Type: Grant
    Filed: September 17, 1998
    Date of Patent: April 22, 2003
    Assignee: Euro-Celtique S.A.
    Inventors: Ronald M. Burch, Paul D. Goldenheim, Richard S. Sackler
  • Methods for treatment of scleroderma
    Publication number: 20030073711
    Abstract: Substituted condensation products of N-benzyl-3-indenylacetamides with heterocyclic aldehydes and other such inhibitors are useful for the treatment of scleroderma.
    Type: Application
    Filed: August 23, 2001
    Publication date: April 17, 2003
    Inventors: Clark M. Whitehead, Keith A. Earle, Hector W. Alila, W. Joseph Thompson
  • Ultrafine emulsion containing a haloalkynyl derivative
    Publication number: 20030073689
    Abstract: A composition in the form of an ultrafine oil-in-water emulsion in which the mean size of the oil globules ranges from 50 nm to 1000 nm containing a haloalkynyl derivative, preferably 3-iodo-2-propynyl butylcarbamate.
    Type: Application
    Filed: September 26, 2002
    Publication date: April 17, 2003
    Applicant: L'OREAL
    Inventor: Jerome Senee
  • 1-Diphenylmethyl-pyrazole derivatives as opioid receptor ligands
    Publication number: 20030069241
    Abstract: This invention relates to 1-diphenylmethyl-pyrazole derivatives of formula (I): 1
    Type: Application
    Filed: July 23, 2002
    Publication date: April 10, 2003
    Inventors: Stanton F. Mchardy, Michael G. Vetelino