Piperidinyl Or Tetrahydropyridyl Patents (Class 514/266.22)
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Patent number: 6982260Abstract: This invention provides quinazolines that are useful for treating cell proliferative diseases and disorders, such as cardiovascular diseases, infections, cancers, autoimmune diseases, gout, kidney disease, and neurodegenerative diseases and disorders such as Alzheimer's disease. We have now discovered a group of 2-arylamino-7-(alkyl)oxy-8-alkylquinazolines and 8-alkyl-2-arylamino-quinazoline 2,7-diamines that are potent inhibitors of cyclin-dependent kinases (cdks). The compounds are readily synthesized and can be administered by a variety of routes, including orally, and have sufficient bioavailability. This invention also provides pharmaceutical formulations comprising at least one of the quinazoline compounds together with a pharmaceutically acceptable carrier, diluent, or excipient therefor. The invention further provide useful intermediates generated during the production of the quinazoline compounds.Type: GrantFiled: November 3, 2000Date of Patent: January 3, 2006Assignee: Warner-Lambert CompanyInventors: Mark Robert Barvian, Ellen Myra Dobrusin, James Stanley Kaltenbronn, Peter L. Toogood, Roy Thomas Winters, Inderjit S. Sidhu, Rajeshwar Singh, Yadagiri Bathini, Ronald George Micetich
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Patent number: 6949541Abstract: The present invention relates to substituted piperidines of general formula wherein A1, A2, R, R1 and R2 are defined as in claim 1, the tautomers, the diastereomers, the enantiomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable pharmacological properties, particularly CGRP-antagonistic properties, pharmaceutical compositions containing these compounds, their use and processes for preparing them.Type: GrantFiled: December 22, 2000Date of Patent: September 27, 2005Assignee: Boehringer Ingelheim Pharma KGInventors: Klaus Rudolf, Henri Doods, Eckhart Bauer, Rudolf Hurnaus, Wolfgang Eberlein, Alexander Dreyer, Stephan Georg Mueller
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Patent number: 6939870Abstract: A compound represented by the formula I: wherein A represents the following heterocycles: and R1-9 are as defined herein, a composition containing this compound and methods for treating disorders of the serotonin-affected neurological systems utilizing such a compound or composition.Type: GrantFiled: August 29, 2003Date of Patent: September 6, 2005Assignee: WyethInventors: Aranapakam M. Venkatesan, Jamie M. Davis, Yansong Gu
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Patent number: 6930113Abstract: The present invention describes novel nitrosated and/or nitrosylated phosphodiesterase inhibitors, and novel compositions containing at least one nitrosated and/or nitrosylated phosphodiesterase inhibitor, and, optionally, one or more compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, stimulate endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or one or more vasoactive agents. The present invention also provides novel compositions containing at least one phosphodiesterase inhibitor, and one or more compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, stimulate endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or one or more vasoactive agents.Type: GrantFiled: August 13, 2002Date of Patent: August 16, 2005Assignee: Nitromed, Inc.Inventors: David S. Garvey, Inigo Saenz de Tejada, Richard A. Earl, Subhash P. Khanapure
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Patent number: 6900226Abstract: Quinoline and quinazoline derivatives can be used in the form of pharmaceutical preparations as Neuropeptide Y antagonists for the treatment or prevention of arthritis, cardiovascular diseases, diabetes, renal failure, eating disorders and obesity.Type: GrantFiled: August 27, 2001Date of Patent: May 31, 2005Assignee: Hoffman-La Roche Inc.Inventors: Volker Breu, Frank Dautzenberg, Philippe Guerry, Matthias Heinrich Nettekoven, Philippe Pflieger
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Patent number: 6900222Abstract: The present invention concerns compounds of formula (I) a stereochemically isomeric form thereof, an N-oxide form thereof or a pharmaceutically acceptable acid addition salt thereon wherein —Z1—Z2— is a bivalent radical; R1, R2 and R3 are each independently selected from hydrogen, C1-6alkyl, hydroxy, halo and the like; or when R1 and R2 are on adjacent carbon atoms, R1 and R2 taken together may form a bivalent radical of formula; Alk is optionally substituted C1-6alkanediyl; the bivalent radical is a substituted piperidinyl, an optionally substituted pyrrolidinyl, homopiperidinyl, piperazinyl or tropyl; R5 is a radical of formula wherein n is 1 or 2; p1 is 0, and p2 is 1 or 2; or p1 is 1 or 2, and p2 is 0; X is oxygen, sulfur or ?NR9; Y is oxygen or sulfur; R7 is hydrogen, C1-6alkyl, C3-6cycloalkyl, phenyl or phenylmethyl; R8 is C1-6alkyl, C3-6cycloalkyl phenyl or phenylmethyl; R9 is cyano, C1-6alkyl, C3-6cyclo-alkyl, C1-6alkyloxycarbonyl or aminocarbonyl; R10 is hydrogen or C1-6alkyl; and Q is aType: GrantFiled: May 23, 2000Date of Patent: May 31, 2005Assignee: Janssen Pharmaceutica N.V.Inventors: Marcel Frans Leopold De Bruyn, Kristof Van Emelen, Piet Tom Bert Paul Wigerinck, Wim Gaston Verschueren
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Patent number: 6844350Abstract: A febrifugine represented by Formula (A): and an isofebrifugine represented by Formula (B): which exhibit extremely strong activities against tropical malarial protozoan are provided, together with a total synthesis route which enables efficient large scale synthesis of the same.Type: GrantFiled: July 3, 2002Date of Patent: January 18, 2005Assignee: Japan Science and Technology CorporationInventors: Shu Kobayashi, Yusuke Wataya, Hye-Sook Kim
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Patent number: 6844338Abstract: A pharmaceutical compound of the formula (I) in which R1 and R2 are each hydrogen or C1-6 alkyl, R3 is —SR10, —SOR10, —SO2R10, —COR10, —CH2OH or —CONHR11, where R10 is C1-6 alkyl and R11 is hydrogen or C1-6 alkyl, R4, R5, R6 and R7 are each hydrogen or C1-6alkyl, provided that at least one of R4, R5, R6 and R7 is C1-6alkyl, R8 and R9 are each hydrogen, halo, C1-6 alkyl or cyano, n is 0 or 1 and m is 2 or 3, x is a (a) or (b), and y is (c) or (d), wherein R12 and R13 are each hydrogen, C1- alkyl, cyclopropyl or cyclopropyl-C1-6 alkyl; and salts thereof.Type: GrantFiled: May 4, 2001Date of Patent: January 18, 2005Assignee: Eli Lilly and CompanyInventors: John Fairhurst, Peter Gallagher
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Publication number: 20040248890Abstract: The present invention relates to compounds useful as inhibitors of voltage-gated sodium channels and calcium channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.Type: ApplicationFiled: March 3, 2004Publication date: December 9, 2004Inventors: Jesus E. Gonzalez, Dean Mitchell Wilson, Andreas Peter Termin, Peter Diederik Jan Grootenhuis, Yulian Zhang, Benjamin John Petzoldt, Lev Tyler Dewey Fanning, Timothy Donald Neubert, Roger Tung, Esther Martinborough, Nicole Zimmermann
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Publication number: 20040209906Abstract: The use of ketanserin in combination with L-carnitine, some alkanoyl L-carnitines and the pharmacologically acceptable salts thereof is disclosed for the treatment of CRPS.Type: ApplicationFiled: April 28, 2003Publication date: October 21, 2004Applicant: Sigma-Tau industrie Farmaceutiche Riunite S.p.A.Inventors: Claudio Cavazza, Menotti Calvani
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Publication number: 20040209889Abstract: Compounds represented by Formula (I): (I)or pharmaceutically acceptable salts thereof, are effective as NMDA NR2B antagonists useful for relieving pain.Type: ApplicationFiled: July 29, 2003Publication date: October 21, 2004Inventors: Christopher F Claiborne, David A Claremon, Brian E Libby, John W Butcher, John A McCauley, Nigel J Liverton, Peter M Munson, Kevin T Nguyen, Brian Phillips, Wayne Thompson
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Publication number: 20040209907Abstract: The present invention provides a method for the treatment or prevention of thrombocythemia in a patient comprising administering to said patient an effective amount of anagrelide, anagrelide in base form, or a pharmaceutically acceptable salt of anagrelide in a manner whereby first pass liver metabolism is avoided.Type: ApplicationFiled: January 23, 2004Publication date: October 21, 2004Inventor: Richard Franklin
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Publication number: 20040204402Abstract: A compound represented by the formula I: 1Type: ApplicationFiled: August 29, 2003Publication date: October 14, 2004Applicant: WyethInventors: Aranapakam M. Venkatesan, Jamie M. Davis, Yansong Gu
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Publication number: 20040198756Abstract: Piperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly man.Type: ApplicationFiled: May 24, 2004Publication date: October 7, 2004Inventors: David Thomas Davies, Graham Elgin Jones, Roger Edward Markwell, Neil David Pearson
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Publication number: 20040198755Abstract: Piperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly man.Type: ApplicationFiled: May 24, 2004Publication date: October 7, 2004Inventors: Catherine Genevieve Yvette Dartois, Roger Edward Markwell, Guy Marguerite Marie Gerard Nadler, Neil David Pearson
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Patent number: 6800628Abstract: This invention concerns the compounds of formula the N-oxide forms, the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein R1 is C1-6alkyloxy, C2-6alkenyloxy or C2-26alkynyloxy; R2 is hydrogen or C1-6alkyloxy, or when taken together R1 and R2 may form a bivalent radical of formula wherein in said bivalent radicals one or two hydrogen atoms may be substituted with C1-6alkyl, R3 is hydrogen or halo; L is C3-6cycloalkyl, C5-6cycloalkanone, C2-6alkenyl optionally substituted with aryl, or L is a radical of formula —Alk—R4, —Alk—NR5R6, 1-R6-4-piperidinyl, Alk—X—R7, —Alk—Y—C(═O)—R9, or —Alk—Y—C(═O)—NR11R12 wherein each Alk is C1-12alkanediyl; R4 is hydrogen, C1-6alkylsulfonylamino, C3-6cycloalkyl, C5-6cycloalkanone, Ar—, di(Ar)methyl, Ar-oxy- or Het1; R5 is hydrogen or C1-6alkyl; R6 is Het2; R7 is hydrogen, C1-6alkyl, hydroxyC1-6alkyl, C3-6cycloaType: GrantFiled: November 19, 2002Date of Patent: October 5, 2004Assignee: Janssen Pharmaceutica N.V.Inventors: Jean-Paul René Marie Bosmans, Christopher John Love, Marc Gustaaf Celine Verdonck, Joannes Adrianus Jacobus Schuurkes
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Publication number: 20040180886Abstract: This invention relates to peptidyl compounds of the formulas (I) and (II) active as cathepsin S, a cysteine protease, inhibitors. The compounds are selective, reversible inhibitors of the cathepsin S are therefore useful in the treatment of autoimmune and other diseases. The invention also relates to processes for preparing such compounds and pharmaceutical compositions comprising them.Type: ApplicationFiled: March 1, 2004Publication date: September 16, 2004Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.Inventors: Eugene R. Hickey, Wiemen Liu, Sanxing Sun, Yancey David Ward, Erick Richard Roush Young
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Publication number: 20040171627Abstract: The present invention relates to compositions containing quinazolinones. More particularly, the present invention relates to a composition for the treatment of renal fibrosis. This composition includes, as an active ingredient, a quinazolinone derivative such as halofurginone, which is shown herein to slow or prevent progression of renal fibrosis in vivo thereby mitigating or preventing end-stage renal failure.Type: ApplicationFiled: November 24, 2003Publication date: September 2, 2004Applicants: Hadasit, State Of Israel, CollgardInventors: Arnon Nagler, Israel Vlodavsky, Mark Pines, Shai Yarkoni
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Publication number: 20040152707Abstract: Novel compounds of the formula 1Type: ApplicationFiled: January 21, 2004Publication date: August 5, 2004Inventors: Deen Tulshian, Ginny D. Ho, Lisa S. Silverman, Julius J. Matasi, Robbie L. McLeod, John A. Hey, Richard W. Chapman, Ana Bercovici, Francis M. Cuss
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Patent number: 6770641Abstract: The present invention provides a pharmaceutical composition which is useful as a phosphatidylinositol 3 kinase (PI3K) inhibitor and an antitumor agent, and it provides a novel bicyclic or tricyclic fused heteroaryl derivative or a salt thereof which possesses an excellent PI3K inhibiting activity and cancer cell growth inhibiting activity.Type: GrantFiled: June 10, 2003Date of Patent: August 3, 2004Assignees: Yamanouchi Pharmaceutical Co., Ltd., Ludwig Institute for Cancer Research, Imperial Cancer Research Technology Ltd.Inventors: Masahiko Hayakawa, Hiroyuki Kaizawa, Hiroyuki Moritomo, Ken-Ichi Kawaguchi, Tomonobu Koizumi, Mayumi Yamano, Koyo Matsuda, Minoru Okada, Mitsuaki Ohta
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Publication number: 20040147518Abstract: Heterocyclylalkylpiperidine derivatives of general formula (I) 1Type: ApplicationFiled: June 27, 2003Publication date: July 29, 2004Applicant: Aventis Pharma S.A.Inventors: Eric Bacque, Jean-Christophe Carry, Youssef El-Ahmad, Michel Evers, Philippe Hubert, Jean-Luc Malleron, Serge Mignani, Guy Pantel, Michel Tabart, Fabrice Viviani
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Publication number: 20040142949Abstract: Compounds, compositions and methods useful for treating cellular proliferative diseases and disorders, for example, by modulating the activity of KSP, are disclosed.Type: ApplicationFiled: July 23, 2003Publication date: July 22, 2004Inventors: Gustave Bergnes, Whitney W. Smith, Bing Yao, David J. Morgans, Andrew McDonald
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Publication number: 20040138219Abstract: Piperidine derivatives of formula (I) and pharmaceutically derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly in man.Type: ApplicationFiled: January 26, 2004Publication date: July 15, 2004Inventors: David Thomas Davies, Graham Elgin Jones, Roger Edward Markwell, William Miller, Neil David Pearson
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Publication number: 20040138220Abstract: The present invention relates to compounds of the formula I, 1Type: ApplicationFiled: December 23, 2003Publication date: July 15, 2004Applicants: Pfizer, Inc., Pfizer Products, Inc.Inventor: Spiros Liras
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Publication number: 20040132727Abstract: There are provided compounds which can be used in the treatment of diseases mediated by the autophosphorylation of a PDGF receptor, specifically, compounds which can inhibit neointima formation hypertrophy.Type: ApplicationFiled: October 25, 2002Publication date: July 8, 2004Inventors: Teruyuki Sakai, Terufumi Senga, Takayuki Furuta, Atsushi Miwa
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Publication number: 20040132728Abstract: Combinations of atorvastatin and &agr;1 adrenergic receptor antagonists, the use of such combinations in the treatment of benign prostatic hyperplasia (BPH), methods of treating BPH using such combinations and medicaments containing such combinations are described.Type: ApplicationFiled: September 16, 2003Publication date: July 8, 2004Applicant: Pfizer IncInventors: Nicholas Pullen, Richard James Thurlow
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Publication number: 20040116452Abstract: Aminopiperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly in man.Type: ApplicationFiled: November 24, 2003Publication date: June 17, 2004Applicant: SmithKline Beecham p.I.c.Inventors: Roger Edward Markwell, Neil David Pearson
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Publication number: 20040116451Abstract: The use of 4-amino-6,7-dimethoxy-2-(5-methanesulfonamido-1,2,3,4-tetrahydroisoquinol-2-yl)-5-(2-pyridyl)quinazoline, or a pharmaceutically acceptable derivative thereof, for treating LUTS associated with: OAB (with or without concomitant detrusor over activity); pelvic floor dysfunction; or chronic prostatitis, is described.Type: ApplicationFiled: September 17, 2003Publication date: June 17, 2004Applicant: Pfizer Inc.Inventor: Ian William Mills
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Patent number: 6743791Abstract: Described herein are compounds that are useful as protein kinase inhibitors having the formula: wherein Z1 and Z2 are each independently nitrogen or CH and Ring A, TmR1, QR2, UnR3, and Sp are as described in the specification. The compounds are especially useful as inhibitors of ERK2 and for treating diseases in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, diabetes, and cardiovascular disease.Type: GrantFiled: February 8, 2002Date of Patent: June 1, 2004Assignee: Vertex Pharmaceuticals IncorporatedInventors: Jingrong Cao, Jeremy Green, Michael Hale, Francois Maltais, Judy Straub, Qing Tang, Alex Aronov
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Publication number: 20040092524Abstract: The invention concerns compounds corresponding to general formula (I), wherein, in particular: W represents hydrogen, COR6, CSR6, SO2R6, CO(CH2)nR6, (CH2)nR7; X represents CH or N; Y represents (CH2)n, CO, CH2CO, CH═CHCO, CH2CH2CO; Z represents a heterocycle. When Z=pyridine, then Y is other than CO. R1 represents hydrogen, C1-C6 alkyl, halogen OCH3, CF3; R2 and R3, identical or different, represent hydrogen, C1-C6 alkyl; R4 represents a) hydrogen, b) C1-C6 alkyl, c) an aryl, d) a heterocycle; R5 represents hydrogen, COR7R8, SO2R7, CO(CH2)nSR7, CO(CH2)nOR7, CONR7R8, CO(CH2)mCOR7; R6 represents a) a phenyl or a naphthyl, b) a C1-C6 alkyl, a cycloalkyl, c) a heterocycle, d) NR7R8; R7 and R8, identical or different, represent a) hydrogen, C1-C15 alkyl, b) a heterocycle, c) an aryl; n represents 0 to 10; m represents 2 to 10; provided that when Z represents a quinozaline or benzimidazole group, then R5 is other than CH2Ph or methyl and n is other than zero.Type: ApplicationFiled: November 12, 2003Publication date: May 13, 2004Inventors: Michel Perez, Marie Lamothe, Anna Kruczynski, Bridget Hill
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Publication number: 20040067950Abstract: The present invention relates to the method of treating cough with ORL-1 agonists, alone or in combination with additional agents for treating symptoms of cough, allergy or asthma, pharmaceutical compositions comprising the combinations, and to compounds of the formula 1Type: ApplicationFiled: June 17, 2003Publication date: April 8, 2004Applicant: Schering-Plough CorporationInventors: Deen Tulshian, Ginny D. Ho, Lisa S. Silverman, Julius J. Matasi, Robbie L. McLeod, John A. Hey, Richard W. Chapman, Ana Bercovici, Francis M. Cuss
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Publication number: 20040063735Abstract: The present invention relates to compounds of Formula (I) 1Type: ApplicationFiled: May 27, 2003Publication date: April 1, 2004Inventors: Prasad V. Chaturvedula, Ling Chen, Rita Civiello, Charles Mark Conway, Andrew P. Degnan, Gene M. Dubowchik, Xiaojun Han, George N. Karageorge, Guanglin Luo, John E. Macor, Graham Poindexter, Shikha Vig
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Publication number: 20040053928Abstract: Aminopiperidine derivatives and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly in man.Type: ApplicationFiled: September 4, 2003Publication date: March 18, 2004Inventors: David Thomas Davies, Roger Edward Markwell, Neil David Pearson
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Publication number: 20040053950Abstract: Malaria is the most severe tropical parasitic disease that has caused millions of deaths in many countries. The threat of growing drug-resistant parasites requires development of new antimalarial drugs to overcome the emergence of resistance and to control the disease. Febrifugine is the active principle extracted from the Chinese herb Chang Shan (Dichroa febrifuga Lour) that has been used to treat malaria for more than two thousand years. Studies on the efficacy have been hindered due to the emetic effects of febrifugine. The present invention discloses febrifugine, halofuginone and febrifugine derivatives for use as antimalarial agents without the severe emetic effects observed in direct herbal use.Type: ApplicationFiled: June 20, 2003Publication date: March 18, 2004Inventors: Suping Jiang, Thomas Hudson, Wilbur Milhous
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Patent number: 6699861Abstract: Dihydroquinazoline derivatives of the formula where R3 is —(CH2)p—A where p is from 1 to 4 and A is a 5- or 6-membered N-containing heterocyclic ring attached via the N atom or A is —NA′A″ wherein A′ and A″ are the same or different and are each a C1-C4 alkyl group or their pharmaceutically acceptable salts possessing anti-cancer activity.Type: GrantFiled: October 19, 2001Date of Patent: March 2, 2004Assignee: Cancer Research Technology LimitedInventors: Lorraine Skelton, Vassilis Bavetsias, Ann Jackman
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Publication number: 20040039003Abstract: A composition for treating hepatic fibrosis and a method of using and manufacturing the composition are provided. The composition includes a quinazolinone derivative, preferably Halofuginone.Type: ApplicationFiled: March 4, 2003Publication date: February 26, 2004Inventors: Mark Pines, Arnon Nagler
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Publication number: 20040038998Abstract: Aminopiperidine derivatives of formula (I) and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly in man.Type: ApplicationFiled: August 28, 2003Publication date: February 26, 2004Inventors: David Thomas Davies, Graham Elgin Jones, Andrew Peightfoot, Roger Edward Markwell, Neil David Pearson
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Publication number: 20040029901Abstract: Compounds of formula I 1Type: ApplicationFiled: July 3, 2003Publication date: February 12, 2004Inventors: Patrizio Mattei, Werner Mueller, Werner Neidhart, Matthias Heinrich Nettekoven, Philippe Pflieger
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Publication number: 20040029859Abstract: Compounds of formula (I): 1Type: ApplicationFiled: March 12, 2003Publication date: February 12, 2004Applicant: Pfizer Inc.Inventors: Julian Blagg, Michael Jonathan Fray, Mark Llewellyn Lewis, John Paul Mathias, Mark Henryk Stefaniak, Alan Stobie
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Publication number: 20040014755Abstract: Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. These compounds of the present invention are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease.Type: ApplicationFiled: January 10, 2003Publication date: January 22, 2004Inventors: Dhanapalan Nagarathnam, Uday Khire, Davoud Asgari, Jianxing Shao, Xiao-Gao Liu, Chunguang Wang, Barry Hart, Olaf Weber, Mark Lynch, Lei Zhang, Lei Wang
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Publication number: 20040009994Abstract: The present invention provides novel methods of inhibiting pathological conditions related to organ systems which respond to estrogen agonists comprising administering to a mammal in need of such treatment an effective amount of a compound of formula I 1Type: ApplicationFiled: July 7, 2003Publication date: January 15, 2004Applicant: Pfizer Inc.Inventors: David B. MacLean, David D. Thompson
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Publication number: 20040006078Abstract: Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formula (Ia) and (Ib) where R2, R3, R4, R5, R6, R7, R8, Het and X are defined herein. The compounds are useful for treating autoimmune and other diseases. Also disclosed are processes for making such novel compounds.Type: ApplicationFiled: October 1, 2002Publication date: January 8, 2004Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.Inventors: Younes Bekkali, Eugene R. Hickey, Weimin Liu, Usha R. Patel, Denice M. Spero, Sanxing Sun, David S. Thomson, Yancey D. Ward, Erick R. R. Young
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Publication number: 20040006062Abstract: The present application describes sulfonylaminovalerolactams and derivatives thereof of Formula I: 1Type: ApplicationFiled: May 5, 2003Publication date: January 8, 2004Inventors: Joanne M. Smallheer, Donald J. Pinto, Shuaige Wang, Jennifer X. Qiao, Wei Han, Zilun Hu
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Publication number: 20030232826Abstract: Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formula (Ia) and (Ib) where R2, R3, R4, R5, R6, R7, R8, Het and X are defined herein. The compounds are useful for treating autoimmune and other diseases. Also disclosed are processes for making such novel compounds.Type: ApplicationFiled: May 29, 2003Publication date: December 18, 2003Applicant: Boehringer Ingelheim Pharmaciuticals, Inc.Inventors: Younes Bekkali, Eugene R. Hickey, Weimin Liu, Usha R. Patel, Denice M. Spero, Sanxing Sun, David S. Thomson, Yancey D. Ward, Erick R. R. Young
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Publication number: 20030225079Abstract: The present invention relates to the use of specific EGF-receptor antagonists for preparing a pharmaceutical composition for the prevention and/or treatment of benign prostatic hyperplasia and/or prostatic hypertrophy, a method for the treatment or prevention of benign prostatic hyperplasia/prostatic hypertrophy comprising administering an EGF-receptor antagonist of groups (A), (B) or (C), described herein optionally in combination with known compounds for the treatment of benign prostatic hyperplasia/prostatic hypertrophy, as well as associated pharmaceutical compositions.Type: ApplicationFiled: May 8, 2003Publication date: December 4, 2003Applicant: Boehringer Ingelheim Pharma GmbH & CO. KGInventors: Thomas Singer, Stefan Platz, Florian Colbatzky
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Publication number: 20030220338Abstract: This invention relates to compounds that are efflux pump inhibitors and therefore are useful as potentiators of anti-fungal agents for the treatment of infections caused by fungi that employ an efflux pump resistance mechanism.Type: ApplicationFiled: September 12, 2002Publication date: November 27, 2003Inventors: Will J. Watkins, Remy Lemoine, Aesop Cho, Monica Palme
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Publication number: 20030212084Abstract: Piperidine derivatives of formula (I) or a pharmaceutically acceptable derivative thereof and pharmaceutically acceptable derivatives thereof useful in methods of treatment of bacterial infections in mammals, particularly in man.Type: ApplicationFiled: December 20, 2001Publication date: November 13, 2003Inventors: Ian Keith Hatton, Neil David Pearson
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Patent number: 6645971Abstract: A compound given by general formula (1): [wherein T represents oxygen or sulfur atom, Y represents alkyl, cycloalkyl group, etc., ring W represents benzene ring, etc., R1 and R2 represent independently hydrogen atom, lower alkyl group, etc., and R3 represents hydrogen atom, alkyl group, etc. Z represents a group given by formula: {wherein A1 and A2 represent independently hydrogen atom, alkyl group, etc. and G represents straight chain alkylene having 1-6 of the carbon number, etc.} or a group given by formula: {wherein n represents 0, 1 or 2, ring E represents 4-8 membered saturated heterocyclic ring containing nitrogen atom(s), and A3 represents hydrogen atom, alkyl group, etc.}], its prodrug or pharmaceutically acceptable salt thereof is an antagonist against muscarinic receptor that is useful as anticholinergic medicaments, and therefore it is useful as pollakiuria or urinary incontinence remedy.Type: GrantFiled: April 10, 2001Date of Patent: November 11, 2003Assignee: Sumitomo Pharmaceuticals Company LimitedInventors: Masami Muraoka, Kazuki Matsui, Koji Morishita, Naohito Ohashi
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Publication number: 20030191139Abstract: The invention relates to compounds of formula I D—CO—B—A-Het and pharmaceutically acceptable salts thereof where substituents in description have the specified meanings. The compounds are used as thrombin inhibitors.Type: ApplicationFiled: January 31, 2003Publication date: October 9, 2003Inventors: Danijel Kikelj, Lucija Peterlin, Petra Marinko, Matej Breznik, Mojca Stregnar, Bakija Alenka Trampuz, Marjana Fortuna
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Publication number: 20030191110Abstract: The present invention relates to methods for modulating the cholesterol biosynthetic pathway. The level of cholesterol in the body is linked to numerous pathological states. The methods of the present invention alter the transcription levels of genes involved in the cholesterol biosynthesis. The methods of the present invention can used for treating diseases mediated by the cholesterol biosynthetic pathway.Type: ApplicationFiled: November 1, 2002Publication date: October 9, 2003Inventors: Martyn Botfield, Fiona McDonald, Joern Kraetzschmar, Bernhard Lindenthal, Bertold Kreft