Two Of The Cyclos Share At Least Three Ring Members (i.e., Bridged) Patents (Class 514/286)
  • Spartein compounds, their preparation and use
    Patent number: 4755520
    Abstract: Compounds of Formula (I)S--(CH.sub.2).sub.n --A (I)in whichS is a 17-spartein nucleusn is 0 or 1and A is 2-furyl, 2-thienyl or 2-(N-alkyl)pyrryl when n=0, or 3-furyl or 3-thienyl when n=1, or pyridyl or a phenyl group of Formula (II) ##STR1## in which at least one of R.sub.1, R.sub.2 and R.sub.3 is a defined substituent other than hydrogen. Such compounds and corresponding compounds in which A is an unsubstituted phenyl group are useful in pharmaceutical compositions as heart affecting agents. Methods of preparing such compounds and pharmaceutical compositions are also disclosed.
    Type: Grant
    Filed: June 17, 1986
    Date of Patent: July 5, 1988
    Assignee: Kali-Chemie Pharma GmbH
    Inventors: Uwe Schon, Wolfgang Kehrbach, Bernd Hachmeister, Gerd Buschmann, Ulrich G. Kuhl
  • Opiate agonists and antagonists
    Patent number: 4608376
    Abstract: Dihydromorphinone compound of the general formulaHDM.dbd.N--RwhereinHDM is ##STR1## where * indicates binding carbonR1 is an optionally substituted alkyl, alkylene, cycloalkyl, or cycloalkyleneR2 is OH or HR3 is OH or OCH3 andR is N.dbd.R4, N--R4, ##STR2## R4 is an optionally substituted alkyl, alkylene, cycloalkyl, cycloalkylene, aryl, heterocycloalkyl, heterocycloalkylene, or alkenyl, andn is 1-10, and use thereof as an opiate receptor blocker.
    Type: Grant
    Filed: September 30, 1982
    Date of Patent: August 26, 1986
    Assignee: Carolyn McGinnis
    Inventor: Gavril W. Pasternak
  • Substituted and bridged pyridines useful as calcium channel blockers
    Patent number: 4599341
    Abstract: Novel substituted and bridged pyridine compounds useful as calcium channel blockers, pharmaceutical compositions thereof, and methods of treatment are disclosed.
    Type: Grant
    Filed: October 1, 1984
    Date of Patent: July 8, 1986
    Assignee: Merck & Co., Inc.
    Inventors: Wasyl Halczenko, George D. Hartman
  • Bridged pyridine compounds useful as calcium channel blockers and analgesics
    Patent number: 4587253
    Abstract: Novel substituted and bridged pyridine compounds useful as calcium channel blockers and analgesics, pharmaceutical compositions thereof, and methods of treatment are disclosed.
    Type: Grant
    Filed: July 30, 1984
    Date of Patent: May 6, 1986
    Assignee: Merck & Co., Inc.
    Inventors: Wasyl Halczenko, George D. Hartman