Abstract: A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated therein or thereon, or diffusing from the scaffold composition such that the scaffold composition and/or a bioactive composition captures and eliminates undesirable cells from the body a mammalian subject. The devices mediate active recruitment, sequestration, and removal or elimination of undesirable cells from their host.
Type:
Application
Filed:
June 11, 2008
Publication date:
January 27, 2011
Inventors:
David James Mooney, Omar abdel-Rahman Ali
Abstract: The present invention relates to peptides comprising amino acids according to Formula I ((X)l(Y)m)n??(I) wherein l, m and n are integers from 0 to 10; X and Y, which may be the same or different, are an amino acid selected from the group consisting of hydrophobic amino acids and/or cationic amino acids, together with methods for the use of the peptides in the treatment of microbial infections.
Abstract: The present invention relates to compositions and methods for producing therapeutic oligomeric compounds. In one aspect the invention relates to methods for administering the oligomeric compounds for the treatment and prevention of disease, for example, a fungal infection, bacterial infection, or cancer, in a mammal. In particular, the invention relates to medicaments comprising various novel oligomeric compounds and pharmaceutically acceptable salts thereof. The compounds of the invention may optionally be administered with at least one of a pharmaceutically acceptable excipient, pharmacologically active agent or a combination thereof.
Type:
Application
Filed:
February 18, 2010
Publication date:
November 25, 2010
Applicants:
Centre National de la Recherche Scientifique (CNRS), I.B.M.C., ImmuPharma France SA, Technopole
Inventors:
Aude Violette, Jean-Paul Briand, Robert H. Zimmer, Gilles Guichard
Abstract: The present invention relates to a truncated form of the secretory aspartyl proteinase 2 (Sap2), as well as to nucleic acid molecules encoding same. This truncated Sap2 polypeptide (tSap2) is surprisingly stable and devoid of enzymatic activity but retains full immunogenicity upon intravaginal administration and confers full protection against intravaginal challenge by the Candida fungus. The present invention further relates to compositions comprising tSap2 and to the use of tSap2 in the preparation of such compositions.
Type:
Application
Filed:
September 19, 2008
Publication date:
November 11, 2010
Applicants:
Pevion Biotech Ltd., Istituto Superiore di Sanita
Inventors:
Rinaldo Zurbriggen, Flavia De Bernardis, Antonio Cassone, Silvia Rasi
Abstract: The disclosure relates to compounds of the formula (I): wherein R1, R2, R3, and R4 are as defined in the disclosure, or a pharmaceutically acceptable salt thereof; which is formed by the microorganism ST 201196 (DSM 18870); the use thereof for the treatment and/or prophylaxis of fungal disorders; medicaments containing a compound of formula (I); processes for production thereof; and the microorganism ST 201196 (DSM 18870).
Type:
Application
Filed:
December 17, 2009
Publication date:
October 7, 2010
Applicant:
SANOFI-AVENTIS
Inventors:
Holger HOFFMANN, Christine KLEMKE-JAHN, Dietmar SCHUMMER, Herbert KOGLER
Abstract: The invention relates to compositions comprising a compound based on the general formula (I) R1-Arg-R2—NH—CH(R3)—CH2—NH—R4??(I) The composition may be used to eliminate and/or reduce microorganisms such as bacteria, viruses, fungi and protozoa.
Type:
Application
Filed:
March 8, 2010
Publication date:
September 30, 2010
Applicant:
Neobiotics AB
Inventors:
Anders Grubb, Aftab Jasir, Claes Schalén, Franciszek Kasprzykowski, Regina Kasprzykowska