Fungus (e.g., Athlete's Foot, Ringworm, Etc.) Destroying Or Inhibiting Patents (Class 514/3.3)
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Patent number: 12171911Abstract: The present invention provides a multilayer matrix comprising at least two layers in which the first layer comprises a bioresorbable material and the second layer comprises a bioadhesive material, wherein the second layer contains cells. A method for producing a multilayer matrix and the use of a multilayer matrix are also provided.Type: GrantFiled: March 22, 2019Date of Patent: December 24, 2024Assignees: QUEEN MARY UNIVERSITY OF LONDON, KANEKA CORPORATIONInventors: Ken Suzuki, Nobuyoshi Umeda
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Patent number: 12083165Abstract: The present invention concerns Thymosin alpha 1 (T?1) for use in treatment of cystic fibrosis as a CFTR corrector, CFTR potentiator and anti-inflammatory agent.Type: GrantFiled: October 28, 2022Date of Patent: September 10, 2024Assignee: SCICLONE PHARMACEUTICALS INTERNATIONAL (SG) PTE. LTD.Inventors: Luigina Romani, Enrico Garaci
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Patent number: 11999357Abstract: A wellness diagnostic platform installed on a vehicle to identify potential passengers with evident symptoms of a contagious illness is described. The wellness diagnostic platform includes a wellness monitoring unit and a boarding confirmation unit. The wellness monitoring unit includes a camera and/or one or more thermal sensors. The camera may capture physical characteristics of the potential passenger to determine health and the thermal sensors can measure a temperature of the potential passenger prior to boarding the vehicle. The boarding confirmation unit is configured to receive at least a display object identifying a diagnostic result computed by the wellness monitoring unit that the potential passenger is (i) advised to board the vehicle when a temperature of the potential passenger is equal to or below a prescribed temperature threshold or (ii) advised to refrain from boarding the vehicle when the temperature of the potential passenger exceeds prescribed temperature threshold.Type: GrantFiled: December 6, 2021Date of Patent: June 4, 2024Assignee: Endera CorporationInventor: John Joseph Walsh
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Patent number: 11946026Abstract: A fragrance composition composed of a high-performance fragrance component and isopropyl myristate is provided. Use of isopropyl myristate as a solvent provides for an increase in the perceived fragrance intensity of a fabric care product, in particular under dry stage conditions.Type: GrantFiled: June 4, 2021Date of Patent: April 2, 2024Assignee: INTERNATIONAL FLAVORS & FRAGRANCES INC.Inventors: Miguel A. Teixeira, Franco Doro
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Patent number: 11903990Abstract: A method of diminishing the appearance of or effecting the removal or disappearance of seborrheic keratoses by the application of compositions containing a) one or more, preferably a combination of, dietary antioxidants and/or antioxidant sources, b) one or more hydrating agents and c) one or more keratolytic agents.Type: GrantFiled: January 15, 2022Date of Patent: February 20, 2024Inventor: William Van Dover Stoecker
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Patent number: 11860161Abstract: Disclosed herein are methods of treatment of autoimmune diseases such as systemic lupus erythematosus (SLE) as well as clinical assays for detection of autoimmune disease activity in patients utilizing a PD1 ligand.Type: GrantFiled: August 5, 2019Date of Patent: January 2, 2024Assignee: Seattle Children's HospitalInventors: Neelufar Mozaffarian, Anne M. Stevens
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Patent number: 11839686Abstract: RNA encoding an immunogen is delivered in a liposome for the purposes of immunisation. The liposome includes lipids which have a pKa in the range of 5.0 to 7.6 and, preferably, a tertiary amine. These liposomes can have essentially neutral surface charge at physiological pH and are effective for immunisation.Type: GrantFiled: December 22, 2021Date of Patent: December 12, 2023Assignee: GLAXOSMITHKLINE BIOLOGICALS SAInventor: Andrew Geall
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Patent number: 11819584Abstract: Methods and cleaning compositions for reduction of nucleic acid contamination on surfaces, in air, and in solutions using modified pectin are provided.Type: GrantFiled: August 16, 2019Date of Patent: November 21, 2023Assignee: CepheidInventors: Alex I. Kutyavin, Kevin P. Lund, Oliver Z. Nanassy, Alexander A. Gall, William Brabant
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Patent number: 11793858Abstract: Antimicrobial compositions having bactericidal activity are described. Also described is a method of treating bacterial infections using compositions comprising antimicrobial peptides or variants thereof.Type: GrantFiled: April 15, 2019Date of Patent: October 24, 2023Assignee: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATIONInventors: C. Cheng Kao, Antonio Cembellin Prieto, Dean Rowe-Magnus
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Patent number: 11786467Abstract: RNA encoding an immunogen is delivered in a liposome for the purposes of immunisation. The liposome includes lipids which have a pKa in the range of 5.0 to 7.6 and, preferably, a tertiary amine. These liposomes can have essentially neutral surface charge at physiological pH and are effective for immunisation.Type: GrantFiled: December 22, 2021Date of Patent: October 17, 2023Assignee: GLAXOSMITHKLINE BIOLOGICALS SAInventor: Andrew Geall
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Patent number: 11766401Abstract: RNA encoding an immunogen is delivered in a liposome for the purposes of immunisation. The liposome includes lipids which have a pKa in the range of 5.0 to 7.6 and, preferably, a tertiary amine. These liposomes can have essentially neutral surface charge at physiological pH and are effective for immunisation.Type: GrantFiled: December 22, 2021Date of Patent: September 26, 2023Assignee: GlaxoSmithKline Biologicals SAInventor: Andrew Geall
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Patent number: 11766068Abstract: The method includes first adding at least one first chelator to smokeless tobacco, second adding at least one first antioxidant to the smokeless tobacco, the at least one first antioxidant being different than the at least one first chelator, and third adding at least one first flavorant to the smokeless tobacco, wherein the first adding occurs before the third adding.Type: GrantFiled: March 9, 2020Date of Patent: September 26, 2023Assignee: Altria Client Services LLCInventors: Marc W. Fariss, Jeffery Edmiston, Dongmei Xu, Randall Baren, Yahya Kargalioglu, James A. Strickland
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Patent number: 11746111Abstract: In one aspect, the invention provides compounds and methods that are useful for treating bacterial infections:Type: GrantFiled: July 19, 2019Date of Patent: September 5, 2023Assignee: YALE UNIVERSITYInventors: Mark Plummer, Denton Hoyer, Elizabeth Spencer
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Patent number: 11730700Abstract: RNA encoding an immunogen is delivered in a liposome for the purposes of immunisation. The liposome includes lipids which have a pKa in the range of 5.0 to 7.6 and, preferably, a tertiary amine. These liposomes can have essentially neutral surface charge at physiological pH and are effective for immunisation.Type: GrantFiled: December 22, 2021Date of Patent: August 22, 2023Assignee: GLAXOSMITHKLINE BIOLOGICALS SAInventor: Andrew Geall
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Patent number: 11584778Abstract: A fusion protein is provided, comprising i) a biologically active polypeptide; and ii) a half-life extending polypeptide moiety comprising 2-80 units independently selected the amino acid sequences according to SEQ ID NO: 1: X1-X2-X3-X4-X5-X6-D-X8-X9-X10-X11 (SEQ ID NO: 1) in which, independently: X1 is P or absent; X2 is V or absent; X3 is P or T; X4 is P or T; X5 is T or V; X6 is D, G or T; X8 is A, Q or S; X9 is E, G or K; X10 is A, E P or T; and X11 is A, P or T. The half-life extending polypeptide moiety has a generally unfolded conformation and provides a fusion protein with a large hydrodynamic radius that may avoid renal clearance. As a result, the biological half-life of the fusion protein is increased and the biological effect of the biologically active polypeptide may thus be prolonged.Type: GrantFiled: April 16, 2018Date of Patent: February 21, 2023Assignee: Swedish Orphan Biovitrum AB (publ)Inventors: Joakim Nilsson, Erik Nordling, Stefan Svensson Gelius
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Patent number: 11548912Abstract: The present invention relates to a compound of formula (I) AA-AA-AA-R1—R2 (I) wherein, in any order, 2 of said AA (amino acid) moieties are cationic amino acids and 1 of said AA is an amino acid with a lipophilic R group, the R group having 14-27 non-hydrogen atoms; R1 is a N atom, which may be substituted by a branched or unbranched C1-C10 alkyl or aryl group, which group may incorporate up to 2 heteroatoms selected from N, O and S; and R2 is an aliphatic moiety having 2-20 non-hydrogen atoms, said moiety being linear, branched or cyclic. The invention further relates to formulations containing these compounds, solid supports having these compounds attached thereto, the use of these compounds in therapy, particularly as antimicrobial, anti-tumour or anti-biofilm agents and non-therapeutic uses of these compounds, particularly their use in inhibiting biofilm formation or removing a biofilm.Type: GrantFiled: December 9, 2020Date of Patent: January 10, 2023Assignee: Peptide Patents ASInventors: Wenche Stensen, Frederick A. Leeson, Oystein Rekdal, John S. Svendsen
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Patent number: 11517858Abstract: A nanoporous polymer membrane with vertically aligned pore channels can be synthesized through self-assembly of amphiphilic block copolymers on a supporting substrate. The pore surface chemistry can be functionalized for selective anion transport.Type: GrantFiled: June 17, 2020Date of Patent: December 6, 2022Assignee: National Technology & Engineering Solutions of Sandia, LLCInventors: Hongyou Fan, Susan Rempe, Ying-Bing Jiang
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Patent number: 11510822Abstract: An improved therapeutic adhesive patch for application to the heel is described for treating or preventing heel disorders or conditions, such as cracked heel.Type: GrantFiled: December 29, 2017Date of Patent: November 29, 2022Assignee: EUROMED, INC.Inventors: Ljiljana Sakotic, Matthew J. Clemente, Nohora Cárdenas
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Patent number: 11266712Abstract: Aspects of the present invention relate to peptides having antimicrobial activity. In certain aspects, the invention relates to peptides having potent antimicrobial activity, broad-spectrum antimicrobial activity, and/or the ability to kill otherwise antibiotic-resistant microbes, or microbes protected by biofilms.Type: GrantFiled: January 24, 2020Date of Patent: March 8, 2022Assignee: Riptide Bioscience, Inc.Inventors: Jesse M. Jaynes, L. Edward Clemens, Henry Wilfred Lopez, George R. Martin, Kathryn Woodburn
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Patent number: 10946065Abstract: The invention relates to methods of treating a fungal infection in a subject in need thereof comprising administering to the subject a therapeutically effective amount of a composition comprising one or more antifungal peptides selected from the group consisting of BmKn2, dBmKn2, Kn2-7, and dKn2-7. Antifungal pharmaceutical compositions and dosage forms, including field-deployable dosage forms, comprising one or more of these antifungal peptides are also contemplated herein.Type: GrantFiled: December 17, 2019Date of Patent: March 16, 2021Assignee: The United States of America, as Represented by the Secretary of the NavyInventors: Nancy Millenbaugh, Jeremy Wesley Gleaton, Dickson Kiprono Kirui
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Patent number: 10897900Abstract: Disclosed are hypersensitive-response eliciting peptides that exhibit improved solubility, stability, resistance to chemical degradation, or a combination of these properties. Use of these peptides or fusion polypeptides, or DNA constructs encoding the same, for modulating plant biochemical signaling, imparting disease resistance to plants, enhancing plant growth, imparting tolerance to biotic stress, imparting tolerance and resistance to abiotic stress, imparting desiccation resistance to cuttings removed from ornamental plants, imparting post-harvest disease or post-harvest desiccation resistance to a fruit or vegetable, or enhancing the longevity of fruit or vegetable ripeness are also disclosed.Type: GrantFiled: August 23, 2016Date of Patent: January 26, 2021Assignee: PLANT HEALTH CARE, INC.Inventors: Zhongmin Wei, Gregory A. Zornetzer
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Patent number: 10780144Abstract: The disclosure relates to methods of prophylactic and therapeutic treatments of a Pneumocystis infection (i.e., an infection caused by Pneumocystis jirovecii) in a subject by administering to the subject a compound of any of formulas (I)-(III) (e.g., a salt of Compound 1, or a neutral form thereof). The disclosure also relates to methods of inhibiting the replication of a Pneumocystis spp. The methods of the disclosure can be useful in immunocompromised subjects.Type: GrantFiled: August 1, 2019Date of Patent: September 22, 2020Assignee: Cidara Therapeutics, Inc.Inventors: Kenneth Bartizal, Paul Daruwala, Voon Ong, Maureen Roden, Taylor Sandison, Dirk Thye
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Patent number: 10500164Abstract: The present invention provides a nano-particle based structure or composition for a combinational cancer therapy. The structure has a doxorubicin (DOX) physically loaded on core-shell silver polymeric nanoparticles (AgN-Ps) with a ratio of 3.3-5.5% doxorubicin to 1% silver to 2-10% polymer. This structure enhances the cellular uptake of DOX in comparison to the current conventional combination therapy. The DOX-loaded nano-particles result in an improved the therapeutic efficiency of DOX, and reduced its toxicity, which cannot occur in case of adding DOX and AgNPs.Type: GrantFiled: September 18, 2015Date of Patent: December 10, 2019Assignee: The American University in CairoInventors: Nancy Mohamed Elbaz, Wael Mamdouh Sayed Sayed Ahmed, Laila Ziko, Rania Siam
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Patent number: 10478474Abstract: The present invention concerns Thymosin alpha 1 for use in treatment of cystic fibrosis as a CFTR corrector, CFTR potentiator and anti-inflammatory agent.Type: GrantFiled: February 4, 2016Date of Patent: November 19, 2019Assignee: SciClone Pharmaceuticals International, Ltd.Inventors: Luigina Romani, Enrico Garaci
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Patent number: 10085442Abstract: The present invention relates to a composition comprising an aqueous continuous phase; a first dispersed phase which comprises styrene-maleimide copolymer particles; and a second dispersed phase which is either oil droplets, suspended particles or a capsule suspension; and to use of those compositions to control agricultural pests or diseases. It also relates to use of such compositions where rainfastness is important.Type: GrantFiled: April 28, 2015Date of Patent: October 2, 2018Assignee: SYNGENTA PARTICIPATIONS AGInventors: John Henry Nettleton-Hammond, Niall Rae Thomson, Dirk Armand Wim Stanssens
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Patent number: 9745335Abstract: The invention provides semisynthetic N-substituted derivatives of the antifungal antibiotic Amphotericin B and water soluble salts and complexes, pharmaceutical compositions and plant and building treatment products comprising the derivatives and their use as antifungal antibiotics.Type: GrantFiled: June 14, 2013Date of Patent: August 29, 2017Assignee: BLIRT S.A.Inventors: Edward Borowski, Natalia Salewska, Joanna Boros-Majewska, Maria Milewska, Malgorzata Wysocka, Slawomir Milewski, Izabela Chabowska, Michal Sabisz
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Patent number: 9611230Abstract: The present invention relates to methods, compounds, and compositions for treating or preventing diseases associated with nonsense mutations in an mRNA by administering the compounds or compositions of the present invention. More particularly, the present invention relates to methods, compounds, and compositions for suppressing premature translation termination associated with a nonsense mutation in an mRNA.Type: GrantFiled: October 13, 2005Date of Patent: April 4, 2017Assignee: PTC Therapeutics, Inc.Inventors: Neil G. Almstead, Guangming Chen, Gary M. Karp, Ellen Welch, Richard Wilde, Jeffrey A. Campbell
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Patent number: 9580470Abstract: A high purity cyclopeptide crystal has a structure shown by Formula I. R represents H or a cation forming a pharmaceutically acceptable salt. Also disclosed are a preparation method and a use of the high-purity cyclopeptide crystal.Type: GrantFiled: March 29, 2013Date of Patent: February 28, 2017Assignee: Shanghai Techwell Biopharmaceutical Co., LTD.Inventors: Shidong Liu, Zhaoli Zhang, Xiusheng Wang, Xiao Zhang, Zhijun Tang, Xiaoming Ji
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Patent number: 9556223Abstract: The present invention relates to a compound of formula (I) AA-AA-AA-R1—R2 (I) wherein, in any order, 2 of said AA (amino acid) moieties are cationic amino acids and 1 of said AA is an amino acid with a lipophilic R group, the R group having 14-27 non-hydrogen atoms; R1 is a N atom, which may be substituted by a branched or unbranched C1-C10 alkyl or aryl group, which group may incorporate up to 2 heteroatoms selected from N, O and S; and R2 is an aliphatic moiety having 2-20 non-hydrogen atoms, said moiety being linear, branched or cyclic. The invention further relates to formulations containing these compounds, solid supports having these compounds attached thereto, the use of these compounds in therapy, particularly as antimicrobial, anti-tumor or anti-biofilm agents and non-therapeutic uses of these compounds, particularly their use in inhibiting biofilm formation or removing a biofilm.Type: GrantFiled: October 2, 2009Date of Patent: January 31, 2017Assignee: LYTIX BIOPHARMA ASInventors: Wenche Stensen, Frederick Alan Leeson, Øystein Rekdal, John Sigurd Svendsen
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Patent number: 9546197Abstract: Provided is a method for preparing a compound represented by Formula I or a salt thereof, wherein Coleophoma empetri F-11899 (FERM BP2635) and/or a mutant strain thereof is cultured in a medium containing amino acid or a salt thereof, an insoluble organic source, and a sugar alcohol, to produce the compound of Formula I or a salt thereof.Type: GrantFiled: January 31, 2012Date of Patent: January 17, 2017Assignee: Shanghai Techwell Biopharmaceutical Co., Ltd.Inventors: Shidong Liu, Zhaoli Zhang, Yi Chen, Xiusheng Wang, Liangliang Zhou, Xiaoming Ji
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Patent number: 9446091Abstract: Disclosed are a high purity of caspofungin or salts thereof, and a preparation method thereof, and use thereof. Disclosed are a caspofungin or salts thereof with low solvent residue and hyposaline, and a preparation process comprising: dissolving a crude product of caspofungin or salts thereof into a system of water and acetic acid, then mixing with a first organic solvent ethyl alcohol, subsequently mixing with a second organic solvent ethyl acetate, then being subject to filtration and drying together with water, to obtain caspofungin or salts thereof with high stability, low solvent residue and hyposaline.Type: GrantFiled: April 20, 2012Date of Patent: September 20, 2016Assignee: Shanghai Techwell Biopharmaceutical Co., Ltd.Inventors: Bingming He, Ming Li, Zhijun Tang, Xiaoming Ji
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Patent number: 9393307Abstract: The present invention relates to a composition comprising caspofungin or a pharmaceutical acceptable salt thereof and succinate or lactate as a buffering agent.Type: GrantFiled: November 19, 2014Date of Patent: July 19, 2016Assignee: XELLIA PHARMACEUTICALS APSInventors: Swapnil P. Shirode, Piyush Patel, Suresh Gidwani, Neil Parikh, Atul Patil, Anita Bevetek Mochnik
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Patent number: 9217014Abstract: The invention features echinocandin class compounds. The compounds can be useful for the treatment of fungal infections.Type: GrantFiled: April 1, 2014Date of Patent: December 22, 2015Assignee: Cidara Therapeutics, Inc.Inventors: Kenneth Duke James, Jr., Christopher Patrick Laudeman, Navdeep Balkrishna Malkar, Balasingam Radhakrishnan
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Patent number: 9149502Abstract: Disclosed is a low impurity content caspofungin pharmaceutical composition and a method for preparing the low impurity content caspofungin pharmaceutical composition. The caspofungin pharmaceutical composition comprises the compound of formula I and/or a pharmaceutically acceptable salt thereof, in combination with a saccharide protective agent(s) and an amino acid(s). The caspofungin pharmaceutical composition is prepared by dissolving the saccharide protective agent and the amino acid into water or a suitable buffer solution; adding the caspofungin compound and dissolving it; filtering the solution and lyophilizing.Type: GrantFiled: September 25, 2012Date of Patent: October 6, 2015Assignee: Shanghai Techwell Biopharmaceuticals Co., Ltd.Inventors: Yunhai Hong, Ying Xue, Lixin Sha, Xiaoming Ji
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Patent number: 9149435Abstract: Disclosed is a low impurity content caspofungin pharmaceutical composition and a method for preparing the low impurity content caspofungin pharmaceutical composition. The caspofungin pharmaceutical composition comprises the compound of formula I and/or a pharmaceutically acceptable salt thereof, in combination with a saccharide protective agent(s) and an amino acid(s). The caspofungin pharmaceutical composition is prepared by dissolving the saccharide protective agent and the amino acid into water or a suitable buffer solution; adding the caspofungin compound and dissolving it; filtering the solution and lyophilizing.Type: GrantFiled: September 25, 2012Date of Patent: October 6, 2015Assignee: Shanghai Techwell Biopharmaceutical Co., Ltd.Inventors: Yunhai Hong, Ying Xue, Lixin Sha, Xiaoming Ji
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Patent number: 9115180Abstract: The current invention relates to the use of a peptide comprising an amino acid sequence in the preparation of a medicament for the regeneration of tissue, preferably for the treatment of a wound. Further the invention relates to compositions comprising such peptides, and use of said peptides in both medical and nonmedical (cosmetic) applications.Type: GrantFiled: March 14, 2013Date of Patent: August 25, 2015Assignee: Rapid Pathogen Screening, Inc.Inventors: Johannes Gerhardus Maria Bolscher, Arie van Nieuw Amerongen, Engelmundus Cornelis Ignatius Veerman, Menno Johannes Oudhoff, Willem van't Hof, Kamran Nazmi, Petronella Adriana Maria van den Keijbus
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Patent number: 9109039Abstract: A 23 amino acid peptide, AtPep1, plays an important role as a signaling component of the innate immune system of Arabidopsis. The peptide precursor gene is transcribed in response to elicitors generated by pathogens, and AtPep1 is produced to amplify the signaling pathways. Seven paralogs of the AtproPep1 gene have been identified in the Arabidopsis genome, and orthologs have been identified in species of several agriculturally important families. AtPep1 and its paralogs and orthologs play important roles as endogenous signals to amplify innate immunity. The sequences of two AtPep1 receptors from Arabidopsis are also provided.Type: GrantFiled: January 31, 2014Date of Patent: August 18, 2015Assignee: Washington State UniversityInventors: Clarence A. Ryan, Gregory L. Pearce, Alisa Huffaker, Yube Yamaguchi
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Publication number: 20150147283Abstract: The present invention provides methods for limiting development of skin wounds, and also for treatment of one or more of erythemas, blisters, rashes, pruritis, contact dermatitis, psoriasis, eczema, acne, and athlete's foot.Type: ApplicationFiled: March 14, 2013Publication date: May 28, 2015Inventors: Kathleen E. Rodgers, Gere S. diZerega
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Publication number: 20150133365Abstract: A novel polypeptide which has an excellent angiogenesis-inducing activity and an excellent antibacterial activity, and a novel angiogenesis-inducing agent which contains the polypeptide as an effective ingredient or a novel agent for treating a wound(s) which contains the polypeptide as an effective ingredient are disclosed. The polypeptide of the present invention is a polypeptide whose amino acid sequence is shown in any one of SEQ ID NOs:1 to 6, 8 and 10. The angiogenesis-inducing agent which contains the polypeptide of the present invention as an effective ingredient is useful for the prevention, amelioration or treatment of a disease such as a burns, decubitus, wound, skin ulcer, leg ulcer, diabetic ulcer, occlusive arterial disease and arteriosclerosis obliteran.Type: ApplicationFiled: January 23, 2015Publication date: May 14, 2015Applicant: ANGES MG, INC.Inventors: Takefumi Gemba, Hideki Tomioka, Nao Tamura, Ryoko Sata, Akito Maeda, Akiko Tenma, Toshihide Kanamori, Yoshimi Saito, Shintaro Komaba, Ryuichi Morishita
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Publication number: 20150126434Abstract: A composition including an artificially synthesized antimicrobial peptide that is not present as a mature peptide in nature. The composition includes an artificially synthesized peptide that has an antimicrobial activity against at least one strain of bacteria or fungi and includes an amino acid sequence represented by any one of SEQ ID NOs: 1 to 6 or an amino acid sequence formed by substituting, deleting and/or adding one, two or three amino acid residues in/from/to the amino acid sequence, and further including at least one species of pharmaceutically acceptable carrier.Type: ApplicationFiled: May 23, 2013Publication date: May 7, 2015Applicant: TOAGOSEI CO., LTD.Inventors: Nahoko Kobayashi, Tetsuhiko Yoshida
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Patent number: 9017956Abstract: Provided herein are uses of genes for HOG, Ras and cAMP signal transduction pathways to treat fungal infection. To regulate the HOG pathway of Cryptococcus neoformans, roles of SSK1, TCO2, SSK2, PBS2, HOG1, ENA1 and NHA1 genes were investigated to find that a biosynthesis level of ergosterol is increased when these genes are inhibited. When the genes are inhibited, a large amount of ergosterol is distributed on a fungal cell membrane. Accordingly, since there are many working points of an ergosterol-binding antifungal agent, an efficiency of the ergosterol-binding antifungal agent can be considerably improved. To regulate the Ras and cAMP pathways of Cryptococcus neoformans, roles of RAS1, RAS2, CDC24, GPA1, CAC1, ACA1, PKA1, HSP12 and HSP122 genes were investigated to find that a sensitivity to a polyene- or azole-based drug is increased when these genes are inhibited.Type: GrantFiled: April 15, 2013Date of Patent: April 28, 2015Assignee: Nutrex Technology Co., Ltd.Inventors: Yong-Sun Bahn, Young-Joon Ko, Shin-Ae Maeng, Kwang Woo Jung, Gyu Bum Kim
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Publication number: 20150104492Abstract: The present invention provides synthetic antibacterial peptides comprising a sequence at least 80% identical to a sequence shown in SEQ ID NO: 2 or the diastereomer thereof with a sequence shown in SEQ ID NO: 3 or pharmaceutical compositions thereof. Also provided are methods for reducing the severity of microbe-induced inflammation and for stimulating wound healing via the synthetic antibacterial peptides. Further provided is a device having a surface with a coating comprising the synthetic antibacterial peptides.Type: ApplicationFiled: October 3, 2014Publication date: April 16, 2015Inventors: Alison McDermott, Marialuisa Mangoni
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Publication number: 20150080289Abstract: Disclosed are amphiphilic peptides. Also disclosed are methods of treating proliferative disease, bacterial infection, viral infection and fungal infection, endotoxin neutralization and a method of removing biofilm. Also disclosed is the use of the amphiphilic peptides.Type: ApplicationFiled: August 29, 2013Publication date: March 19, 2015Inventors: Yi-Yan Yang, Zhan Yuin Ong
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Publication number: 20150067917Abstract: Provided is a system for protecting plants from attack by pests, including pathogens such as fungi. Specifically, a plant defensin is provided in conjunction with a protease inhibitor protects a plant from pest attack or reduces severity of an attack.Type: ApplicationFiled: November 6, 2014Publication date: March 5, 2015Inventors: Robyn Louise HEATH, Marilyn Anne ANDERSON, Nicole Louise VAN DER WEERDEN, James Anthony MCKENNA, Simon POON
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Publication number: 20150045287Abstract: The invention relates to a method of controlling or combating microbial organism by applying an antimicrobial peptide to the microbial organisms, wherein said antimicrobial peptide derived from Lilium ‘Stargazer’ glycine-rich protein 1. In addition, the present invention provides an antimicrobial composition comprising an antimicrobial peptide of the invention, an additional biocidal agent and pharmaceutically acceptable vehicles, excipients, diluents, and adjuvants.Type: ApplicationFiled: August 9, 2013Publication date: February 12, 2015Applicant: National Taiwan UniversityInventors: Chao-Ying CHEN, Chia-Hua LIN, Min-Wei CHANG
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Patent number: 8951958Abstract: The present invention relates to a method for the purification of cyclopeptides of general formula (3) by means of a silicate.Type: GrantFiled: March 22, 2011Date of Patent: February 10, 2015Assignee: DSM Sinochem Pharmaceuticals Netherlands B.V.Inventor: Robertus Mattheus De Pater
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Publication number: 20150037281Abstract: The present invention relates to novel Prothymosin Alpha (ProT?) variants that are capable of inducing cell-mediated immune responses. These variants lack a nuclear localization signal and the proliferative oncogenic activity previously attributed to ProT?. The variants of the invention are used in methods of treating, for example, viral infections, bacterial infections, fungal infections, cancer, ischemia and myeloproliferative blood disorders. Administration of a ProT? variant to a subject in a therapeutically effective amount treats the infection or disease.Type: ApplicationFiled: March 1, 2013Publication date: February 5, 2015Applicant: Icahn School of Medicine at Mount SinaiInventors: Arevik Mosoian, Avelino Teixeira
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Patent number: 8940684Abstract: The disclosure describes collagen constructs comprising antifungal agents, preferably, copper, and related methods.Type: GrantFiled: March 15, 2013Date of Patent: January 27, 2015Assignee: MiMedx Group, Inc.Inventor: Thomas J. Koob
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Publication number: 20150011389Abstract: The present invention relates to active compound combinations for reducing the damage of plants and plant parts as well as losses in harvested fruits or vegetables caused by insects, nematodes or phytopathogens and which have fungicidal or nematicidal or insecticidal activity including any combination of the three activities, in particular within a composition, which comprises (A) Fluopyram and (B) one biological control agent, in particular bacteria, fungi or yeasts, protozoa, viruses, entomopathogenic nematodes, inoculants, botanicals and products produced by microorganisms including proteins or secondary metabolites. Moreover, the invention relates to a method for curatively or preventively controlling insects, nematodes or phytopathogens on the plant, plant parts, harvested fruits or vegetables, to the use of a combination according to the invention for the treatment of seed, to a method for protecting a seed and not at least to the treated seed.Type: ApplicationFiled: January 22, 2013Publication date: January 8, 2015Inventor: Elke Hellwege
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Publication number: 20150011465Abstract: Novel peptoid oligomers are disclosed that have a formula represented by the following formula I: The peptoids demonstrate antimicrobial activity and may be prepared as pharmaceutical compositions and used for the prevention or treatment of a variety of conditions in mammals including humans where microbial invasion is involved. The present cyclic and linear peptoids are particularly valuable as their effect is rapid, broad in spectrum and mostly indifferent to resistance provoked by standard antibiotics.Type: ApplicationFiled: September 9, 2014Publication date: January 8, 2015Inventors: Kent Kirshenbaum, Sung Bin Shin