Yeast Patents (Class 514/3.5)
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Publication number: 20150080289Abstract: Disclosed are amphiphilic peptides. Also disclosed are methods of treating proliferative disease, bacterial infection, viral infection and fungal infection, endotoxin neutralization and a method of removing biofilm. Also disclosed is the use of the amphiphilic peptides.Type: ApplicationFiled: August 29, 2013Publication date: March 19, 2015Inventors: Yi-Yan Yang, Zhan Yuin Ong
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Patent number: 8889134Abstract: The invention relates to modulation of fungal morphology between yeast-to-hyphal growth transition by controlling muramyl-L-alanine concentration and uses thereof.Type: GrantFiled: January 22, 2013Date of Patent: November 18, 2014Assignee: Agency for Science, Technology and ResearchInventors: Yue Wang, Xiao-Li Xu, Raymond Teck Ho Lee
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Publication number: 20140206601Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of respiratory tract infections. More particularly, the present invention relates to a TLR5 agonist for use in a method for treating a respiratory tract infection.Type: ApplicationFiled: February 20, 2014Publication date: July 24, 2014Applicants: Institut Pasteur de Lille, Institut National de la Sante et de la Recherche Medicale (INSERM)Inventors: Jean-Claude Sirard, Jose A. Chabalgoity
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Publication number: 20140162938Abstract: Peptide compounds based on the CAP37 protein are disclosed, along with methods for treating various infections, wounds, and conditions, and methods of promoting healing and acceptance of grafts, using compositions containing these peptides.Type: ApplicationFiled: December 3, 2013Publication date: June 12, 2014Applicant: The Board of Regents of the University of OklahomaInventor: Heloise Anne Pereira
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Publication number: 20140155318Abstract: Compositions comprising an isolated peptide, which may for example optionally comprise a sequence selected from the group consisting of FDYDWY (SEQ ID NO: 2), SFSQNKSVHSFDYDWYNVSDQADLKN (SEQ ID NO: 3) or CSFSQNKSVHSFDYDWYNVSDQADLKNC (SEQ ID NO: 1), or any cyclized version thereof, and methods of using same, including for treatment of or prevention of formation of microbial biofilms and against adhesion of a cell to a surface.Type: ApplicationFiled: September 3, 2013Publication date: June 5, 2014Applicant: Tel Hashomer Medical Research, Infrastructure and Services Ltd.Inventor: Amir ZLOTKIN
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Publication number: 20140082769Abstract: The present application belongs to the field of functional peptides and more particularly to the field of controlled protein aggregation. The invention discloses molecules of a peptide structure as defined in the claims and methods of using such molecules for therapeutic applications and for diagnostic uses, as well as in other applications such as in the agbio field and in industrial biotechnology. The molecules can be used for curing and/or stabilizing infections such as bacterial, fungal and viral diseases, but are also useful in non-infectious human and veterinary diseases. The molecules can also be used for the detection of protein biomarkers and for the prognosis and diagnosis of a variety of diseases.Type: ApplicationFiled: March 12, 2012Publication date: March 20, 2014Inventors: Joost Schymkowitz, Frederic Rousseau
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Publication number: 20130345119Abstract: The present invention provides an antimicrobial peptide polymer comprising at least one monomer which is digested by pepsin, a multimeric antimicrobial peptide complex comprising the polymer and a cell surface anchoring motif linked to the polymer, an antimicrobial microorganism displaying the multimeric antimicrobial peptide complex, an antimicrobial composition comprising the same, a method of treating an infectious disease caused by bacteria, yeast or fungi by administering the antimicrobial composition, and a method for producing the antimicrobial microorganism. According to the invention, living microorganisms displaying an antimicrobial peptide on the cell surface thereof may be administered in vivo without having to lyse the microbial cell and isolate and purify the antimicrobial peptide, so that the antimicrobial peptide exhibits antimicrobial activity. Thus, the antimicrobial peptide may be produced at significantly reduced costs so that it may have widespread use.Type: ApplicationFiled: December 28, 2010Publication date: December 26, 2013Applicants: INTELLIGENT SYNTHETIC BIOLOGY CENTER, KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGYInventors: Sun-Chang Kim, Ju Ri Shin, Ki Jung Lim, Da Jung Kim, Young Woong Lee, Su A Jang, Bong Hyun Sung
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Publication number: 20130336950Abstract: A material combination is configured to treat or prevent inflammatory and infectious diseases caused by fastidious anaerobic or facultative anaerobic microorganisms, such as bacteria or Candida sp. The material combination includes at least one antimicrobial peptide that can be activated by a reducing substance, and at least one reducing agent.Type: ApplicationFiled: August 19, 2011Publication date: December 19, 2013Inventors: Jan Wehkamp, Bjoern Schroeder, Eduard Stange
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Publication number: 20130288953Abstract: The inventors provide the use of a composition comprising an antimicrobial polypeptide comprising Blad or an active variant thereof to prevent or inhibit spoilage of a foodstuff by a microorganism. Also provided is a method of preventing or inhibiting spoilage of a foodstuff by a microorganism comprising administering to a foodstuff in need thereof an effective amount of a composition comprising an antimicrobial polypeptide comprising Blad or an active variant thereof.Type: ApplicationFiled: October 12, 2011Publication date: October 31, 2013Applicant: CONSUMO EM VERDE-BIOTENOLOGIA DAS PLANTAS S.A. (PT/PT)Inventors: Alexandra Manuela Lourenço Carreira, Sara Alexandra Valadas Da Silva Monteiro, Ricardo Manuel De Seixas Boavida Ferreira
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Publication number: 20130150286Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of respiratory tract infections. More particularly, the present invention relates to a TLR5 agonist for use in a method for treating a respiratory tract infection.Type: ApplicationFiled: June 25, 2010Publication date: June 13, 2013Inventors: Jean-Claude Sirard, Jose A. Chabalgoity
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Publication number: 20130108575Abstract: This invention provides novel antimicrobial peptides and formulations thereof. The peptides and/or formulations are effective to kill or to inhibit the growth and/or proliferation of various bacteria, yeast, and fungi.Type: ApplicationFiled: October 16, 2012Publication date: May 2, 2013Applicant: C3 JIAN, INC.Inventor: C3 Jian, Inc.
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Patent number: 8404633Abstract: The present invention refers to pharmaceutical compositions comprising the soluble CD5 ectodomain and its use for the prevention and/or treatment of fungal infections and/or fungal sepsis, as well as inflammatory disorders of fungal origin.Type: GrantFiled: June 19, 2009Date of Patent: March 26, 2013Assignees: Hospital Clinic I Provincial de Barcelona, Universitat de Barcelona, Fundacio Clinic per a la Recerca BiomedicaInventors: Francisco Lozano Soto, Jorge Vera Fernandez
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Publication number: 20130064809Abstract: A composition for prophylactic and/or therapeutic medicinal applications, or plant protection applications, in particular for the control of microorganisms, either planktonic or organized in biofilms. The composition includes at least one ion selected from hypohalite, at least one compound selected from lactoferrin, lactoferrin peptide, lysozyme, immunoglobulins or a combination thereof, optionally hypothiocyanite, and optionally at least one growth factor.Type: ApplicationFiled: August 6, 2012Publication date: March 14, 2013Inventor: Jean-Paul PERRAUDIN
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Patent number: 8383110Abstract: The invention relates to modulation of fungal morphology between yeast-to-hyphal growth transition by controlling muramyl-L-alanine concentration and uses thereof.Type: GrantFiled: August 21, 2007Date of Patent: February 26, 2013Assignee: Agency for Science, Technology and ResearchInventors: Yue Wang, Xiao-Li Xu, Teck Ho Raymond Lee
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Publication number: 20120295837Abstract: A novel class of antimicrobial polymeric agents, which include a plurality of amino acid residues, such as positively charged amino acid residues, and at least one hydrophobic residue linking therebetween, such as an omega-amino-fatty acid residue, designed to exert antimicrobial activity while being stable, non-toxic and avoiding development of resistance thereto and a process of preparing same are disclosed. Further disclosed are pharmaceutical compositions containing same and a method of treating medical conditions associated with pathological microorganisms, a medical device, an imaging probe and a food preservative utilizing same. Further disclosed are conjugates of an amino acid residue and a hydrophobic moiety residue and a process of preparing same.Type: ApplicationFiled: December 8, 2011Publication date: November 22, 2012Applicant: Technion Research & Development Foundation Ltd.Inventors: Amram MOR, Inna RADZISHEVSKY
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Publication number: 20120189682Abstract: The present invention relates to a product comprising at least two antibiofilm agents wherein at least one of the antibiofilm agents is an antimicrobial peptide. The second antibiofilm agent is generally a dispersant or an anti-adhesive agent. There is also provided the use of the product in the treatment of a microbial infection.Type: ApplicationFiled: March 31, 2010Publication date: July 26, 2012Applicant: Novabiotics LimitedInventors: Deborah O'Neil, Derry Mercer, Cedric Charrier
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Patent number: 8211691Abstract: Cell lines having genetically modified glycosylation pathways that allow them to carry out a sequence of enzymatic reactions, which mimic the processing of glycoproteins in humans, have been developed. Recombinant proteins expressed in these engineered hosts yield glycoproteins more similar to their human counterparts. The lower eukaryotes, which ordinarily produce high-mannose containing N-glycans, including unicellular and multicellular fungi are modified to produce N-glycans such as Man5GlcNAc2 or other structures along human glycosylation pathways.Type: GrantFiled: October 30, 2007Date of Patent: July 3, 2012Assignee: Glycofi, Inc.Inventor: Tillman U. Gerngross
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Publication number: 20120015870Abstract: Compositions comprising an isolated peptide, which may for example optionally comprise a sequence selected from the group consisting of FDYDWY (SEQ ID NO: 2), SFSQNKSVHSFDYDWYNVSDQADLKN (SEQ ID NO: 3) or CSFSQNKSVHSFDYDWYNVSDQADLKNC (SEQ ID NO: 1), or any cyclized version thereof, and methods of using same, including for treatment of or prevention of formation of microbial biofilms and against adhesion of a cell to a surface.Type: ApplicationFiled: December 28, 2009Publication date: January 19, 2012Applicant: TEL HASHOMER MEDICAL RESEARCH, INFRASTRUCTURE AND SERVICES LTD.Inventor: Amir Zlotkin
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Publication number: 20110280920Abstract: Compositions comprising an isolated peptide, which may for example optionally comprise a sequence selected from the group consisting of YDYNWY (SEQ ID NO: 1), YDYNLY (SEQ ID NO: 2), FDYNFY (SEQ ID NO: FDYNLY (SEQ ID NO: 4), FDYNWY (SEQ ID NO: 5), YDWNLY (SEQ ID NO: 6), YDWHLY (SEQ ID NO: 7) and WDYNLY (SEQ ID NO: 8), extracted from organisms such as aquatic organisms and mossor any other sequence described herein, and methods of using same, including for treatment of or prevention of formation of microbial biofilms and against adhesion of a cell to a surface.Type: ApplicationFiled: September 23, 2009Publication date: November 17, 2011Inventors: Amir Zlotkin, Hen Kestenboim
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Publication number: 20110269673Abstract: The present invention relates to peptides comprising amino acids according to Formula I ((X)l(Y)m)n ??(I) wherein l, m and n are integers from 0 to 10; X and Y, which may be the same or different, are an amino acid selected from the group consisting of hydrophobic amino acids and/or cationic amino acids, together with methods for the use of the peptides in the treatment of microbial infections.Type: ApplicationFiled: June 28, 2011Publication date: November 3, 2011Applicant: NOVABIOTICS LIMITEDInventor: Deborah O'Neil
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Publication number: 20110223202Abstract: The invention discloses an amphiphilic antimicrobial substance comprising a hydrophobic portion coupled to a cationic oligopeptide portion. The cationic oligopeptide portion may comprise a protein transduction domain coupled to a cationic oligopeptide group.Type: ApplicationFiled: December 18, 2008Publication date: September 15, 2011Inventors: Yi-Yan Yang, Lihong Liu
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Publication number: 20110039763Abstract: This invention provides novel targeted antimicrobial compositions. In various embodiments chimeric moieties are provided comprising an antimicrobial peptide attached to a peptide targeting moiety that binds a bacterial strain or species.Type: ApplicationFiled: January 6, 2010Publication date: February 17, 2011Applicant: C3 JIAN, INC.Inventors: RANDAL H. ECKERT, CHRIS KAPLAN, JIAN HE, DANIEL K. YARBROUGH, MAXWELL ANDERSON, JEE-HYUN SIM
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Publication number: 20110039761Abstract: This invention provides novel targeted antimicrobial compositions. In various embodiments chimeric moieties are provided comprising an antimicrobial peptide attached to a peptide targeting moiety that binds a bacterial strain or species.Type: ApplicationFiled: January 6, 2010Publication date: February 17, 2011Applicant: C3 JIAN, INC.Inventors: RANDAL H. ECKERT, CHRIS KAPLAN, JIAN HE, DANIEL K. YARBROUGH, MAXWELL ANDERSON, JEE-HYUN SIM
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Publication number: 20110039762Abstract: This invention provides novel targeted antimicrobial compositions. In various embodiments chimeric moieties are provided comprising an antimicrobial peptide attached to a peptide targeting moiety that binds a bacterial strain or species.Type: ApplicationFiled: January 6, 2010Publication date: February 17, 2011Applicant: C3 JIAN, INC.Inventors: RANDAL H. ECKERT, CHRIS KAPLAN, JIAN HE, DANIEL K. YARBROUGH, MAXWELL ANDERSON, JEE-HYUN SIM
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Publication number: 20110028385Abstract: A compound comprising combination of an immunomodulator and to at least one anti-pathogenic agent for treating of facultative or strict infections caused by intracellular microorganisms, the components of the combination or association of substances of the invention, the immunomodulator (proteic aggregate of ammonium and magnesium phospholinoleate-palmitoleate anhydride) and at least one substance with antimicrobial properties can be administered either jointly, simultaneously, consecutively or sequentially, in an appropriate form, according to their chemical properties, and in a dose effective against microorganisms in human and animals.Type: ApplicationFiled: January 27, 2009Publication date: February 3, 2011Inventor: Iseu da Silva Nunes
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Publication number: 20110021415Abstract: The present invention relates to peptides comprising amino acids according to Formula I ((X)l(Y)m)n??(I) wherein l, m and n are integers from 0 to 10; X and Y, which may be the same or different, are an amino acid selected from the group consisting of hydrophobic amino acids and/or cationic amino acids, together with methods for the use of the peptides in the treatment of microbial infections.Type: ApplicationFiled: September 29, 2010Publication date: January 27, 2011Applicant: NOVABIOTICS LIMITEDInventor: DEBORAH O'NEIL
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Publication number: 20100322872Abstract: The present invention provides a method for prophylaxis and therapy of infectious diseases caused by microorganisms present in biofilms adherent to cell surfaces comprising the step of administering to an individual in need thereof a composition comprising a combination of at least one compound chosen from the group of peroxidase, lactoferrin, lactoferrin peptides, lysozyme and immunoglobulins and at least one growth factor.Type: ApplicationFiled: August 3, 2010Publication date: December 23, 2010Inventor: Jean-Paul Perraudin
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Publication number: 20100278807Abstract: A novel class of antimicrobial polymeric agents which are designed to exert antimicrobial activity while being stable, non-toxic and avoiding development of resistance thereto and a process of preparing same are disclosed. Further disclosed are pharmaceutical compositions containing same and a method of treating medical conditions associated with pathological microorganisms, a medical device, an imaging probe and a food preservative utilizing same. Further disclosed are conjugates of an amino acid residue and a hydrophobic moiety residue and a process of preparing same.Type: ApplicationFiled: September 16, 2008Publication date: November 4, 2010Applicant: Technion Research & Development Foundation Ltd.Inventors: Amram Mor, Inna Radzishevsky