The Additional Hetero Ring Consists Of Two Nitrogens And Three Carbons Patents (Class 514/341)
  • Patent number: 10351557
    Abstract: The present invention relates to compounds of the formula (I), to the use of compounds of the formula (I) in electronic devices, and to electronic devices containing one or more compounds of the formula (I). The invention furthermore relates to preparation processes for compounds of the formula (I) and to formulations comprising one or more compounds of the formula (I).
    Type: Grant
    Filed: May 23, 2011
    Date of Patent: July 16, 2019
    Assignee: Merck Patent GmbH
    Inventors: Rocco Fortte, Christof Pflumm, Constanze Brocke, Amir Hossain Parham
  • Patent number: 10347387
    Abstract: Graphene, a composition for preparing graphene, and a method of preparing graphene using the composition are disclosed.
    Type: Grant
    Filed: August 10, 2017
    Date of Patent: July 9, 2019
    Assignee: HANWHA AEROSPACE CO., LTD.
    Inventors: Dukhwa Na, Dongkwan Won, Euisoo Park, Jaechul Ryu
  • Patent number: 10238636
    Abstract: The present disclosure relates to a method of preventing and/or treating liver disease comprising administering an ASK1 inhibitor in combination with a FXR agonist, to a patient in need thereof.
    Type: Grant
    Filed: September 22, 2015
    Date of Patent: March 26, 2019
    Assignee: Gilead Sciences, Inc.
    Inventors: Jamie Geier Bates, David Gordon Clarkson Breckenridge, John T. Liles, William J. Watkins
  • Patent number: 10233182
    Abstract: The present invention relates to compounds according to Formula I and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancer, lymphocyte homing, chronic inflammation, neuropathic pain, fibrotic diseases, thrombosis, and cholestatic pruritus, mediated at least in part by ATX.
    Type: Grant
    Filed: February 14, 2018
    Date of Patent: March 19, 2019
    Assignee: X-Rx, Inc.
    Inventors: Lee Babiss, Matthew Clark, Anthony D. Keefe, Mark J. Mulvihill, Haihong Ni, Louis Renzetti, Frank Ruebsam, Ce Wang, Zhifeng Xie, Ying Zhang
  • Patent number: 10226438
    Abstract: Methods of treating a subject having or at risk of developing a neurodegenerative disease or condition associated with demyelination, insufficient myelination, or underdevelopment of myelin sheath are described. The methods include administration of a therapeutically effective amount of sobetirome, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: February 5, 2014
    Date of Patent: March 12, 2019
    Assignees: Oregon Health & Science University, The United States of America as represented by the Department of Veterans Affairs
    Inventors: Thomas S. Scanlan, Meredith Hartley, Andrew Placzek, Marco Righi, Dennis Bourdette, Gail Marracci, Priya Chaudhary
  • Patent number: 10207996
    Abstract: Compounds having activity as PKM2 activators are disclosed. The compounds have the following structure (I): including stereoisomers, tautomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R3, R4, R5 and R6 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
    Type: Grant
    Filed: June 15, 2016
    Date of Patent: February 19, 2019
    Assignee: Tolero Pharmaceuticals, Inc.
    Inventors: Koc-Kan Ho, Yong Xu, Michael David Saunders, Xiaohui Liu, Scott Albert Pearce, Kevin Bret Wright, Jason Marc Foulks, Kenneth Mark Parnell, Steven Brian Kanner, David Lee Vollmer, Jihua Liu
  • Patent number: 10184134
    Abstract: Soybean plants comprising event SYHT0H2, methods of detecting and using the same, and soybean plants comprising a heterologous insert at the same site as SYHT0H2.
    Type: Grant
    Filed: December 9, 2011
    Date of Patent: January 22, 2019
    Assignee: Syngenta Participations AG
    Inventors: John Daniel Hipskind, Kristina Burgin, Rakesh Jain, Karolyn Terpstra, Marina Sigareva, Annick Jeanne De Framond, Becky Breitinger, Vance Cary Kramer, Weining Gu
  • Patent number: 10125100
    Abstract: There are provided compounds of formulas III and VIIa: or a salt or protected derivative thereof, wherein Z2 represents a structural fragment of formula V, wherein R1A to R1E, R2 to R4, R5a, L and X1 to X3 have meanings given in the description, which compounds have antiinflammatory activity, for example through inhibition of one or more of members of: the family of p38 mitogen-activated protein kinase enzymes; Syk kinase; and members of the Src family of tyrosine kinases) and have use in therapy, including in pharmaceutical combinations, especially in the treatment of inflammatory diseases, including inflammatory diseases of the lung, eye and intestines.
    Type: Grant
    Filed: May 24, 2017
    Date of Patent: November 13, 2018
    Assignees: Topivert Pharma Limited
    Inventors: Thomas Matthew Baker, Matthew Colin Thor Fyfe, Geraint Jones, Stephen Malcolm Thom
  • Patent number: 10092546
    Abstract: The present invention relates to compounds of formula I wherein R1? is CH3; R1 is methyl, ethyl, CF3, CH2OH, cyclopropyl or cyano, or R1? and R1 may form together a 1,1-dioxo-tetrahydro-thiophen-3-yl ring; R2 is hydrogen, methyl, ethyl, isopropyl, tertbutyl, cyclopropyl, hydroxmethyl, or 2-propyl-2-ol; R3 is Cl, F, CF3, methyl, methoxy, isopropyl, cyano or cyclopropyl; R4 is hydrogen, methyl, F or Cl; or to a pharmaceutically acceptable salt or acid addition salt, to a racemic mixture, or to its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof. The compounds of formula I may be used in the treatment of psychiatric disorders such as schizophrenia, bipolar disorder, obsessive-compulsive disorder or autism spectrum disorder.
    Type: Grant
    Filed: January 9, 2018
    Date of Patent: October 9, 2018
    Assignee: Hoffman-La Roche Inc.
    Inventors: Marius Hoener, Juergen Wichmann
  • Patent number: 10093668
    Abstract: Disclosed are substituted aromatic N-heterocyclic compounds. The disclosed compounds typically exhibit kinase inhibition activity, for example, and inhibit Mnk1 kinase and/or Mnk2 kinase. The disclosed compounds may be used in pharmaceutical compositions and methods for treating diseases or disorders associated with Mnk1 kinase activity and/or Mnk2 kinase activity, such as cancers, diabetes, autism, and fragile X syndrome.
    Type: Grant
    Filed: October 28, 2016
    Date of Patent: October 9, 2018
    Assignee: Northwestern University
    Inventors: Gary E. Schiltz, Rama K. Mishra, Leonidas C. Platanias, Javier Izquierdo-Ferrer
  • Patent number: 10047071
    Abstract: A dihydropyrimidinone derivative includes a compound having a chemical structure according to Formula 1: Z is selected from O, S and N; Y is N X is selected from O and S; and R represents aryl, substituted aryl, heteroaryl, or substituted heteroaryl, wherein the substituted aryl or substituted heteroaryl have one or more substituents selected from the group consisting of halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, nitro, hydroxyl, alkylthio, alkylamino, heteroaryl, aryloxy, haloaryloxy, arylthio, arylamino, and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: January 15, 2018
    Date of Patent: August 14, 2018
    Assignee: KING SAUD UNIVERSITY
    Inventors: Mashooq Ahmad Bhat, Mohamed A. Al-Omar
  • Patent number: 10018637
    Abstract: Provided herein are methods for predicting the clinical sensitivity of an inflammatory disease (e.g., ankylosing spondylitis) and a subject's response to treatment with apremilast using the level of a biomarker (e.g., MCP1). Also provided herein are methods for treating an inflammatory disease.
    Type: Grant
    Filed: October 5, 2016
    Date of Patent: July 10, 2018
    Assignee: CELGENE INTERNATIONAL II SARL
    Inventors: Peter H. Schafer, Matthew William Burnell Trotter
  • Patent number: 9988366
    Abstract: Compounds of formula (I), wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoismers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides and can be prepared in a manner known per se.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: June 5, 2018
    Assignee: Syngenta Participations AG
    Inventors: Michel Muehlebach, Ruud Titulaer, Daniel Emery, Andrew Edmunds, Andre Stoller, Pierre Joseph Marcel Jung, Anke Buchholz, Peter Renold
  • Patent number: 9944604
    Abstract: The invention relates to a composition comprising at least one aminobenzamide compound or a salt thereof for controlling animal parasites, veterinary pharmaceutical compositions comprising at least one aminobenzamide of formula (I) for preventing infection with diseases transmitted through parasites, its use for the preparation of a veterinary pharmaceutical for controlling animal parasites, and a method for preventing infection with diseases transmitted through parasites.
    Type: Grant
    Filed: April 26, 2012
    Date of Patent: April 17, 2018
    Assignee: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Ulrich Görgens, Akihiko Yanagi, Kazue Yanagi, Keisuke Yanagi, Kasumi Yanagi, Katsuaki Wada, Tetsuya Murata, Yukiyoshi Watanabe, Jun Mihara, Koichi Araki
  • Patent number: 9931329
    Abstract: Phenyl triazole derivative (specifically, 1-[6-[[5-(2-fluorophenyl)-3-methyl-triazol-4-yl]methoxy]-3-pyridyl]imidazole-4-carbonitrile or a pharmaceutically acceptable salt thereof), pharmaceutical compositions containing this compound, and methods of treatment therewith. The compound is in particular considered useful for the treatment of central nervous system diseases and disorders which are responsive to modulation of GABAA receptors containing the ?5 subunit.
    Type: Grant
    Filed: November 16, 2015
    Date of Patent: April 3, 2018
    Assignee: SANIONA A/S
    Inventors: Janus Schreiber Larsen, Magnus Gustafsson, Carsten Jessen
  • Patent number: 9913835
    Abstract: The present invention relates to methods of inducing the self-renewal of stem/progenitor supporting cells, including inducing the stem/progenitor cells to proliferate while maintaining, in the daughter cells, the capacity to differentiate into hair cells. Specifically, the invention relates to methods of using compounds comprising a N-(1H-pyrazol-4-yl)-nicotinamide moiety having a Formula I: and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: March 13, 2018
    Assignee: Frequency Therapeutics, Inc.
    Inventors: Christopher Loose, Will McLean, Melissa Hill-Drzewi
  • Patent number: 9867801
    Abstract: Provided is an amorphous solid dispersion including a taxane or a pharmaceutically acceptable salt thereof, a pharmaceutically acceptable polymer, and a pharmaceutically acceptable surfactant, which has enhanced solubility. Also provided is a method for preparing the solid dispersion. The present subject matter also provides a tablet having good solubility, bioavailability and stability, which comprises the amorphous solid dispersion, an intragranular excipient, and an extragranular excipient.
    Type: Grant
    Filed: March 20, 2015
    Date of Patent: January 16, 2018
    Assignee: HANMI PHARM. CO., LTD.
    Inventors: Shanmugam Srinivasan, Ho Taek Im, Young Su Yoon, Yong Il Kim, Jae Hyun Park, Jong Soo Woo
  • Patent number: 9844218
    Abstract: Provided herein are compounds that exhibit activity as acetyl-CoA carboxylase modulators (e.g., inhibitors) and are useful, for example, in methods for the control of fungal pathogens in plants.
    Type: Grant
    Filed: June 13, 2014
    Date of Patent: December 19, 2017
    Assignee: Monsanto Technology LLC
    Inventors: Urszula Slomczynska, Matthew W. Dimmic, William P. Haakenson, Jr., Jennifer L. Bennett, Barry J. Shortt, Christina M. Taylor, Deryck Jeremy Williams, Martin Slater
  • Patent number: 9820486
    Abstract: Compositions and processes for controlling nematodes are described herein, e.g., nematodes that infest plants or animals. The compounds include oxazoles, oxadiazoles and thiadiazoles.
    Type: Grant
    Filed: May 5, 2016
    Date of Patent: November 21, 2017
    Assignee: Monsanto Technology LLC
    Inventors: Urszula Slomczynska, Matt W. Dimmic, Al Wideman, William P. Haakenson, Jr.
  • Patent number: 9790202
    Abstract: The present invention relates to novel anthranilamide derivatives of the general formula (I) in which R1, R2, R3, R4, R5, R6, A, Q, Y and n are each as defined in the description—, to the use thereof as insecticides and acaricides for control of animal pests, and to several processes for preparation thereof.
    Type: Grant
    Filed: July 8, 2011
    Date of Patent: October 17, 2017
    Assignee: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Rüdiger Fischer, Ernst Rudolf Gesing, Christoph Grondal, Markus Heil, Heinz-Juergen Wroblowsky, Arnd Voerste, Ulrich Gorgens
  • Patent number: 9771328
    Abstract: The present disclosure provides processes for the preparation of a compound of formula: which exhibits apoptosis signal-regulating kinase (“ASK1”) inhibitory activity and is thus useful in the treatment of diseases such as kidney disease, diabetic nephropathy and kidney fibrosis. The disclosure also provides compounds that are synthetic intermediates.
    Type: Grant
    Filed: January 23, 2017
    Date of Patent: September 26, 2017
    Assignee: GILEAD SCIENCES, INC.
    Inventor: Joshua R. Dunetz
  • Patent number: 9708288
    Abstract: This document discloses molecules having the following formula (“Formula One”): and processes related thereto.
    Type: Grant
    Filed: September 2, 2014
    Date of Patent: July 18, 2017
    Assignee: Dow AgroSciences LLC
    Inventors: Ann M. Buysse, Noormohamed M. Niyaz, David A. Demeter, Yu Zhang, Martin J. Walsh, Asako Kubota, Ricky Hunter, Tony K. Trullinger, Christian T. Lowe, Daniel I. Knueppel, Akshay Patny, Negar Garizi, Paul Renee LePlae, Jr., Frank J. Wessels, Ronald Ross, Jr., Carl DeAmicis, Peter Borromeo
  • Patent number: 9701657
    Abstract: The present invention relates generally to compositions and methods for treating cancer and neoplastic diseases. Provided herein are substituted imidazole-pyridine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of histone demethylase enzymes. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.
    Type: Grant
    Filed: September 11, 2015
    Date of Patent: July 11, 2017
    Assignee: Celgene Quanticel Research, Inc.
    Inventors: Toufike Kanouni, Zhe Nie, Jeffrey Alan Stafford, James Marvin Veal
  • Patent number: 9681658
    Abstract: An agrochemical formulation comprising a penetrant and an agrochemical active. The penetrant is an esterified and/or etherified polyol alkoxylate obtainable by directly esterifying and/or etherifying a polyol alkoxylate. There is also provided a method of making the penetrant comprising alkoxylation of a polyol, and esterification or etherification of the formed poyol alkoxylate. The penetrant is suitable for use in agrochemical formulations to enhance penetration of the active across a leaf cuticle.
    Type: Grant
    Filed: November 19, 2013
    Date of Patent: June 20, 2017
    Assignee: Croda International PLC
    Inventors: Trevor Graham Blease, Kathryn Marie Knight
  • Patent number: 9668480
    Abstract: The invention relates to the use of N-cyclopropyl-N-[substituted-benzyl]-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide or thiocarboxamide derivatives and/or salts thereof for improving growth in crops, comprising preventively and/or curatively controlling resistant strains of fungi, particularly for controlling strains of fungi resistant to SDHI fungicides. The invention further relates to associated methods.
    Type: Grant
    Filed: October 17, 2013
    Date of Patent: June 6, 2017
    Assignee: BAYER CROPSCIENCE AG
    Inventors: Pierre Cristau, Marie-Claire Grosjean-Cournoyer, Anne Lappartient, Andreas Mehl, Valerie Toquin, Francois Villalba
  • Patent number: 9648879
    Abstract: A co-crystal composed of a diamide-based insecticidal-active ingredient and a neonicotinoid-based insecticidal-active ingredient is provided as a co-crystal which exhibits excellent insecticidal effects over a long period of time while reducing the occurrence of chemical damage on useful plants. The co-crystal is obtained by a method including heating and stirring of a suspension obtained by suspending the diamide-based insecticidal-active ingredient and the neonicotinoid-based insecticidal-active ingredient in a solvent such as water.
    Type: Grant
    Filed: October 31, 2014
    Date of Patent: May 16, 2017
    Assignee: Nippon Soda Co., Ltd.
    Inventors: Akihiko Ito, Tomohiro Amano, Rieko Masaki
  • Patent number: 9643953
    Abstract: Compounds of formula (I) and their use as pharmaceutical.
    Type: Grant
    Filed: December 17, 2012
    Date of Patent: May 9, 2017
    Assignees: BAYER INTELLECTUAL PROPERTY GMBH, BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Marion Hitchcock, Anne Mengel, Anja Richter, Hans Briem, Knut Eis, Vera Pütter, Gerhard Siemeister, Stefan Prechtl, Amaury Ernesto Fernández-Montalván, Christian Stegmann, Simon Holton, Mark Jean Gnoth, Cornelia Preuβe
  • Patent number: 9616044
    Abstract: The present invention relates to a long-acting composition for the treatment of an animal in need thereof wherein the composition includes a therapeutically effective amount of a bioactive agent, characterized in that the composition includes a non-aqueous carrier and a solvent system comprising castor oil and at least one cyclic amide.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: April 11, 2017
    Inventors: Fadil Al Alawi, Karthigeyan Nanjan
  • Patent number: 9598361
    Abstract: An amino substituted acetamide derivative can include a compound having the following general formula: wherein R represents (4-Cyano-4-phenyl)piperidinyl hydrochloride, (4-Hydroxy-4-phenyl)piperidine, (4-chlorophenyl)piperidine hydrochloride, 4-Piperidinopiperidine, 4-(Methoxyphenyl)piperidine, 1-(2,3-xylyl)piperazine monohydrochloride, 4-Aminoquinaldine or anthranilic acid, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: April 12, 2016
    Date of Patent: March 21, 2017
    Assignee: KING SAUD UNIVERSITY
    Inventors: Amani Shafeek Awaad, Ahmed Mahmoud Ahmed Alafeefy, Reham Mostafa El-Meligy
  • Patent number: 9556207
    Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of degenerative diseases and disorders.
    Type: Grant
    Filed: October 29, 2014
    Date of Patent: January 31, 2017
    Assignee: MUSC FOUNDATION FOR RESEARCH DEVELOPMENT
    Inventors: Craig C. Beeson, Christopher C. Lindsey, Yuri K. Peterson, Baerbel Rohrer
  • Patent number: 9549560
    Abstract: A pesticidal composition comprises at least one compound selected from a 1-(3-pyridyl-N-oxide) pyrazole compound of formula I, II, or III, or any agriculturally acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, R12, R13, Y, and Q, are as described herein. A method of controlling pests comprises applying the pesticidal composition near a population of pests.
    Type: Grant
    Filed: October 17, 2014
    Date of Patent: January 24, 2017
    Assignee: Dow AgroSciences LLC
    Inventors: Martin J. Walsh, Daniel Knueppel, Noormohamed M. Niyaz, Ann M. Buysse, Negar Garizi, Asako Kubota, Yu Zhang, Ricky Hunter, Tony K. Trullinger
  • Patent number: 9518026
    Abstract: The present disclosure is generally directed to compositions and methods for treating apicomplexan protozoan related disease, such as toxoplasmosis and cryptosporidiosis.
    Type: Grant
    Filed: May 20, 2014
    Date of Patent: December 13, 2016
    Assignee: University of Washington Through its Center For Commercialization
    Inventors: Erkang Fan, Wesley C. Van Voorhis, Zhongsheng Zhang, Wenlin Huang, Kayode K. Ojo
  • Patent number: 9512120
    Abstract: The present invention provides compounds of formula (I) wherein Y1, Y2, Y3, G, V1, V2, V3 and V4 are as defined in the claims. The invention further relates to compositions which comprise these compounds and to their use in agriculture or horticulture for controlling or preventing infestation of plants by phytopathogenic microorganisms, preferably fungi.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: December 6, 2016
    Assignee: Syngenta Participations AG
    Inventors: Kurt Nebel, Martin Pouliot
  • Patent number: 9510595
    Abstract: The present invention relates to pesticidal mixtures comprising a component A and a component B, wherein component A is a compound of formula (I) R2 is group X wherein A is A1 or A2 and X1, X2, X3, B1, B2, B3, Y1, Y2, Y3, Z, k, R1 and R5 are as defined in claim 1 and component B is an insecticide. The present invention also relates to methods of using said mixtures for the control of plant pests.
    Type: Grant
    Filed: October 9, 2013
    Date of Patent: December 6, 2016
    Assignee: Syngenta Participations AG
    Inventors: Jerome Yves Cassayre, Myriem El Qacemi
  • Patent number: 9510596
    Abstract: The present invention relates to novel mixtures, to processes for preparing these compounds, to compositions comprising these mixtures, and to the use thereof as biologically active compounds, especially for control of harmful microorganisms or pests in crop protection and in the protection of materials and for enhancing plant health.
    Type: Grant
    Filed: November 27, 2013
    Date of Patent: December 6, 2016
    Assignee: BAYER CROPSCIENCE AG
    Inventors: Haruko Sawada, Stefan Herrmann, Heiko Rieck, Christophe Dubost
  • Patent number: 9497967
    Abstract: A pesticidal composition comprises a synergistically effective amount of a chloride channel activator compound and a pesticide selected from N-(3-chloro-1-(pyridin-3-yl)-1H-pyrazol-4-yl)-N-ethyl-3-((3,3,3-trifluoropropyl)thio) propanamide (I), N-(3-chloro-1-(pyridine-3-yl)-1H-pyrazol-4-yl)-N-ethyl-3-((3,3,3-trifluoropropyl) sulfinyl)propanamide (II), or any agriculturally acceptable salt thereof. A method of controlling pests comprises applying the pesticidal composition near a population of pests. A method of protecting a plant from infestation and attack by pests comprises contacting the plant with the synergistic pesticidal composition.
    Type: Grant
    Filed: May 28, 2015
    Date of Patent: November 22, 2016
    Assignee: Doe AgroSciences LLC
    Inventors: Luis E. Gomez, Ricky Hunter, Mike Shaw, Tony K. Trullinger, Mary E. Kubiszak, John Herbert
  • Patent number: 9499490
    Abstract: The present invention provides a compound of the Formula: wherein X is selected from the group consisting of, R is selected from the group consisting of H and CH3; R1 is selected from the group consisting of H, CH3, F, Cl, OCH3, C(O)OH, C(O)NH2 or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: December 11, 2014
    Date of Patent: November 22, 2016
    Assignee: Eli Lilly and Company
    Inventors: Kevin Kun-Chin Liu, Yinong Xie, Liang Wu, Guoqiang Zhou
  • Patent number: 9493449
    Abstract: The present disclosure provides substituted pyridyl-, pyrimidinyl-, pyrazinyl-, pyridazinyl-, and triazinyl-based carboxamides of Formula I-A: R10 Z-HET-E I-A and the pharmaceutically acceptable salts and solvates thereof, wherein Z, HET, R10 and E are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I-A to treat a disorder responsive to the blockade of sodium channels. Compounds of the present disclosure are especially useful for treating pain.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: November 15, 2016
    Assignee: Purdue Pharma L.P.
    Inventors: Jiangchao Yao, Laykea Tafesse
  • Patent number: 9485989
    Abstract: The invention relates to a method of controlling insects from the order hemiptera that resistant to neo-nicotinoid insecticides using spiroheterocyclic pyrrolidine dione derivatives.
    Type: Grant
    Filed: May 26, 2011
    Date of Patent: November 8, 2016
    Assignee: Syngenta Participations AG
    Inventors: Russell Slater, Alfred Rindlisbacher, Peter Maienfisch, Phillippe Camblin, Alain Gaume
  • Patent number: 9458139
    Abstract: Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: October 4, 2016
    Assignee: Global Blood Therapeutics, Inc.
    Inventors: Qing Xu, Zhe Li, Brian W. Metcalf
  • Patent number: 9457019
    Abstract: The present invention relates to methods of inhibiting TIE2 kinase useful in the treatment of tumor growth, invasiveness, intravazation, dissemination, metastasis, and immunosuppression. Specifically, the invention relates to methods of using 1-(3-tert-butyl-1-(quinolin-6-yl)-1H-pyrazol-5-yl)-3-(2-fluoro-4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)urea and salts thereof of Formula I.
    Type: Grant
    Filed: November 7, 2014
    Date of Patent: October 4, 2016
    Assignee: Deciphera Pharmaceuticals, LLC
    Inventors: Daniel L. Flynn, Michael D. Kaufman, Bryan D. Smith, Marc Rudoltz
  • Patent number: 9457084
    Abstract: This invention relates to a compound with EP4 antagonistic activity, or a pharmaceutically acceptable salt with EP4 receptor antagonistic activities, which is useful in the treatment of immune disease or allergy. This invention also relates to a compound of formula (I), (II), (III), (IV), (Va) or (Vb), or a pharmaceutically acceptable salt thereof with EP4 receptor antagonistic activities, which is useful in the treatment of immune disease or allergy. This invention also relates to a pharmaceutical composition for the treatment of immune disease or allergy which comprises a therapeutically effective amount of a compound of formula (I), (II), (III), (IV), (Va) or (Vb), or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: February 22, 2011
    Date of Patent: October 4, 2016
    Assignee: RAQUALIA PHARMA INC.
    Inventors: Kiyoshi Kanazawa, Kazuhiko Nonomura, Takako Okumura, Shinichi Koizumi
  • Patent number: 9445593
    Abstract: This invention provides a method for soil systemic control of an invertebrate pest by contacting the soil with a biologically effective amount of a compound of Formula 1, an N-oxide or an agriculturally suitable salt thereof wherein R1, R2, R3, R4a, R4b and R5 are as defined in the disclosure.
    Type: Grant
    Filed: July 15, 2015
    Date of Patent: September 20, 2016
    Assignee: E I DU PONT DE NEMOURS AND COMPANY
    Inventors: George Philip Lahm, Thomas Paul Selby, Thomas Martin Stevenson
  • Patent number: 9422268
    Abstract: Compounds of formula (I) and their use as pharmaceutical.
    Type: Grant
    Filed: December 17, 2012
    Date of Patent: August 23, 2016
    Assignee: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Marion Hitchcock, Anne Mengel, Anja Richter, Hans Briem, Knut Eis, Vera Pütter, Gerhard Siemeister, Stefan Prechtl, Amaury Ernesto Fernández-Montalván, Christian Stegmann, Simon Holton, Mark Jean Gnoth, Cornelia Preuβe
  • Patent number: 9416123
    Abstract: Compounds of the substituted pyrazole class as treatments for cancer are reported. A method of treating cancer in which a compound that inhibits the activity of receptor kinases. Said method is effective and can be provided in addition to standard therapies, notably chemotherapy using cytotoxic drugs and other forms of immune therapy including therapeutic vaccines.
    Type: Grant
    Filed: March 28, 2014
    Date of Patent: August 16, 2016
    Assignee: Synovo GmbH
    Inventors: Michael William Burnet, Bassam Abu Thaher, Jan Ehlert, Michael Kubbutat, Christoph Schaechtele, Frank Totzke
  • Patent number: 9414595
    Abstract: The present invention relates to the use of anthranilic acid diamide derivatives with heteroaromatic and heterocyclic substituents of formula (I) wherein R1, R2, R3, R4, R5, R6, n, A, Q have the meanings as given in the description—for controlling animal pests, such as insects and/or unwanted acarids and/or nematodes in transgenic crops and to methods particularly useful for controlling insects, and/or acarids and/or nematodes and/or increasing crop yield in those crops.
    Type: Grant
    Filed: December 17, 2012
    Date of Patent: August 16, 2016
    Assignees: Bayer CropScience AG, Bayer Intellectual Property GmbH
    Inventors: Rüdiger Fischer, Heike Hungenberg, Bill Striegel, Steven Riniker
  • Patent number: 9408390
    Abstract: Insecticide compositions which comprise one or not less than two kinds of compounds being selected from a compound represented by the formula [I]: or a salt thereof, and a neonicotinoid compound represented by the formula [II]: The insecticide compositions can produce higher insecticidal effects than would be expected when each of the active ingredients is used singly, namely a synergistic effect, thus enabling reductions in the rate or number of application of agrochemicals and pesticides to be realized.
    Type: Grant
    Filed: June 22, 2015
    Date of Patent: August 9, 2016
    Assignee: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventor: Yuichi Ohkawara
  • Patent number: 9365543
    Abstract: N-Thio-anthranilamid compounds of formula (I) wherein A is A1 wherein the variables and the indices are as defined per the description, processes for preparing the compounds I, pesticidal compositions comprising compounds I, use of compounds I for the control of insects, acarids or nematodes, and methods for treating, controlling, preventing or protecting animals against infestation or infection by parasites by use of compounds of formula I.
    Type: Grant
    Filed: June 15, 2015
    Date of Patent: June 14, 2016
    Assignee: BASF SE
    Inventors: Thomas Schmidt, Michael Puhl, Joachim Dickhaut, Henricus Maria Martinus Bastiaans, Michael Rack, Deborah L. Culbertson, Douglas D. Anspaugh, Franz-Josef Braun, Toni Bucci, Henry Van Tuyl Cotter, David G. Kuhn, Hassan Oloumi-Sadeghi
  • Patent number: 9358225
    Abstract: Ataxia-telangiectasia (A-T) is a progressive degenerative disorder that results in major neurological disability. In A-T patients, necropsy has revealed atrophy of all cerebellar cortical layers with extensive Purkinje and granular cell loss. We have previously identified an increase in phospho-p38MAPK levels, which was accompanied by downregulation of Bmi-1 and upregulation of p21, as key components of the mechanism causing defective proliferation of neural stem cells (NSCs) isolated from subventricular zone (SVZ) of Atm-null mice. Our results demonstrate that restoration of NSCs by pharmacologic inhibition of p38MAPK signaling has the potential to treat neurological defects of A-T. This study provides new insights into the therapeutic strategy targeting NSCs rather than replacing impaired neurons not only for A-T, but for other neurodegenerative disorders as well.
    Type: Grant
    Filed: March 17, 2014
    Date of Patent: June 7, 2016
    Assignee: Bach Pharma, Inc.
    Inventor: Paul K. Y. Wong
  • Patent number: 9315498
    Abstract: The present invention relates to ethynyl compounds of formula I-C1 wherein R1, R2, R2?, R3, R3?, R6, U, V and W are as defined herein and to a pharmaceutically acceptable acid addition salts, to a racemic mixtures, or to its corresponding enantiomers and/or optical isomers and/or stereoisomers thereof, which are allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5).
    Type: Grant
    Filed: November 20, 2013
    Date of Patent: April 19, 2016
    Assignee: HOFFMAN-LA ROCHE INC.
    Inventors: Luke Green, Wolfgang Guba, Georg Jaeschke, Synese Jolidon, Lothar Lindemann, Antonio Ricci, Daniel Rueher, Heinz Stadler, Eric Vieira