Nitrogen Attached Indirectly To The Six-membered Hetero Ring By Nonionic Bonding Patents (Class 514/357)
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Patent number: 8741927Abstract: The present invention relates to a novel method for preparing a compound of formula (2) as the intermediate, which can be effectively used for preparation of a compound of formula (1) exhibiting good inhibitory activity against dipeptidyl peptidase IV enzyme.Type: GrantFiled: August 25, 2011Date of Patent: June 3, 2014Assignee: LG Life Sciences Ltd.Inventors: Bong Chan Kim, Kyu Young Kim, Hee Bong Lee, Ji Eun An, Kyu Woong Lee
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Publication number: 20140148453Abstract: Disclosed are sulfonamide compounds of Formula (I): or stereoisomers, N-oxides, prodrugs, or pharmaceutically acceptable salts thereof, wherein ring A, R1, R2, R3, R4 and R5 are defined herein. Also disclosed are methods of using such compounds in the treatment of conditions related to CYP17 enzyme, such as cancer, and pharmaceutical compositions comprising such compounds.Type: ApplicationFiled: July 25, 2011Publication date: May 29, 2014Inventors: Joel Francis Austin, Lisa S. Sharma, James Aaron Balog, Audris Huang, Upender Velaparthi, Chetan Padmakar Darne, Mark George Saulnier
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Process for the production of particles comprising active agrochemical ingredients in amorphous form
Patent number: 8735321Abstract: An object of the present invention is a process for the preparation of particles which comprise two agrochemical active ingredients in amorphous form, where a melt comprising the two molten agrochemical active ingredients is emulsified in an aqueous solution and cooled. A further object is the use of an agrochemical active ingredient for inhibiting the crystallization of another agrochemical active ingredient in a preparation process for particles which comprise the two agrochemical active ingredients in amorphous form, where a melt comprising the two molten agrochemical active ingredients is emulsified in an aqueous solution and cooled. A further object is particles which comprise two agrochemical active ingredients in amorphous form. The use in plant protection is also described.Type: GrantFiled: May 6, 2009Date of Patent: May 27, 2014Assignee: BASF SEInventors: Ulrike Troppmann, Winfried Mayer, Sebastian Koltzenburg, Rafel Israels, Andreas Bauder, Ulf Schlotterbeck -
Patent number: 8734772Abstract: Disclosed herein are cosmetic compositions comprising (a) at least one styrene-maleic anhydride copolymer bearing at least one group chosen from styrylpyridine and styrylpyridinium groups and (b) at least one co-film forming agent and/or at least one plasticizer. The cosmetic composition optionally further comprises at least one pigment and at least one solvent. Also disclosed herein are methods for making up and/or enhancing the appearance of a keratinous substrate comprising (1) forming a film on the keratinous substrate by applying to said keratinous substrate a cosmetic composition comprising (a) at least one styrene-maleic anhydride copolymer bearing at least one group chosen from styrylpyridine and styrylpyridinium groups and (b) at least one co-film forming agent and/or at least one plasticizer and (2) exposing the film to radiation chosen from UV and visible light radiation.Type: GrantFiled: December 28, 2012Date of Patent: May 27, 2014Assignee: L'OrealInventors: XianZhi Zhou, Jean-Thierry Simonnet, Hy Si Bui, Chunhua Li
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Publication number: 20140142074Abstract: The invention relates to inhibitors of the phosphodiesterase 4 (PDE4) enzyme. More particularly, the invention relates to compounds that are derivatives of 1-phenyl-2-pyridinyl alkyl alcohols, methods of preparing such compounds, compositions containing them and therapeutic use thereof.Type: ApplicationFiled: January 27, 2014Publication date: May 22, 2014Applicant: Chiesi Farmaceutici S.p.A.Inventors: Elisabetta ARMANI, Gabriele Amari, Carmelida Capaldi, Oriana Esposito, Ilaria Peretto
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Publication number: 20140135320Abstract: The present invention relates to antimalarial compounds and their use against protozoa of the genus Plasmodium, including drug-resistant Plasmodia strains. This invention further relates to compositions containing such compounds and a process for making the compounds.Type: ApplicationFiled: November 8, 2013Publication date: May 15, 2014Applicant: Jacobus Pharmaceutical Company, Inc.Inventors: Gavin David Heffernan, David Penman Jacobus, Kurt William Saionz, Guy Alan Schiehser, Hong-Ming Shieh, Wenyi Zhao
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Publication number: 20140135301Abstract: Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols are useful as inhibitors of the phosphodiesterase 4 (PDE4) enzyme.Type: ApplicationFiled: January 22, 2014Publication date: May 15, 2014Applicant: Chiesi Farmaceutici S.p.A.Inventors: Maurizio Delcanale, Elisabetta Armani, Gabriele Amari
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Publication number: 20140135362Abstract: N-Substituted (6-haloalkylpyridin-3-yl)alkyl sulfoximines are effective at controlling insects.Type: ApplicationFiled: January 17, 2014Publication date: May 15, 2014Applicant: DOW AGROSCIENCES LLCInventors: Michael R. Loso, Benjamin M. Nugent, Jim X. Huang, Richard B. Rogers, Yuanming Zhu, James M. Renga, Vidyadhar B. Hegde, Joseph J. DeMark
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Publication number: 20140135360Abstract: The present invention relates to antimalarial compounds and their use against protozoa of the genus Plasmodium, including drug-resistant Plasmodia strains. This invention further relates to compositions containing such compounds and a process for making the compounds.Type: ApplicationFiled: November 8, 2013Publication date: May 15, 2014Applicant: Jacobus Pharmaceutical Company, IncInventors: Gavin David Heffernan, David Penman Jacobus, Guy Alan Schiehser, Hong-Ming Shieh, Wenyi Zhao
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Patent number: 8722686Abstract: The invention relates to a compound of formula (I): or a pharmaceutically acceptable salt thereof, thereof, wherein: G is a group of formula (II); and pharmaceutically acceptable salts, prodrugs, hydrates, or solvates, thereof, wherein A, B. L1-L4 A, B, R1-R4 and m are as defined herein. The invention also relates to pharmaceutical compositions comprising the compounds of formula (I) and their use in treating a bacterial infection.Type: GrantFiled: September 1, 2009Date of Patent: May 13, 2014Assignee: Pfizer Inc.Inventors: Matthew F. Brown, Charles F. Donovan, Edmund L. Ellsworth, Denton W. Hoyer, Timothy A. Johnson, Manjinder S. Lall, Chris Lim-Berakis, Sean T. Murphy, Debra A. Sherry, Clarke B. Taylor, Joseph S. Warmus
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Patent number: 8722734Abstract: The present invention relates to the a method of inhibiting bone resorption in a mammal in need thereof with an oral pharmaceutical composition comprising a cathepsin K inhibitor, or a pharmaceutically acceptable salt thereof, or a mixture thereof, according to a continuous schedule having a dosage interval of once weekly, biweekly, twice monthly or once monthly.Type: GrantFiled: February 24, 2006Date of Patent: May 13, 2014Assignees: Merck Sharp & Dohme Corp., Merck Canada Inc.Inventors: Anastasia Daifotis, Selwyn Aubrey Stoch, Basil Avery Ince, Cameron Black
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Patent number: 8722895Abstract: The present disclosure relates to HIF-1? prolyl hydroxylase inhibitors, compositions which comprise the HIF-1? prolyl hydroxylase inhibitors described herein and to methods for controlling, inter alia, Peripheral Vascular Disease (PVD), Coronary Artery Disease (CAD), heart failure, ischemia, and anemia.Type: GrantFiled: April 9, 2013Date of Patent: May 13, 2014Assignee: Akebia Therapeutics, Inc.Inventors: Richard M. Kawamoto, Shengde Wu, Artem G. Evdokimov, Kenneth D. Greis, Angelique Sun Boyer, Namal C. Warshakoon
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Publication number: 20140128408Abstract: Histone deacetylases inhibitors (HDACIs) and compositions containing the same are disclosed. Methods of treating diseases and conditions wherein inhibition of HDAC provides a benefit, like a cancer, a neurodegenerative disorder, a peripheral neuropathy, a neurological disease, traumatic brain injury, stroke, hypertension, malaria, an autoimmune disease, autism, autism spectrum disorders, and inflammation, also are disclosed.Type: ApplicationFiled: January 31, 2012Publication date: May 8, 2014Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOISInventors: Alan Kozikowski, Jay H. Kalin, Kyle V. Butier, Joel Bergman, Wayne W. Hancock
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Patent number: 8716285Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt, ester or stereoisomer thereof, wherein R1 to R3 and X have the significances given herein. The present invention is also directed to processes for making said compounds and uses of said compounds, in particular their use as medicaments, more particularly their use as medicaments in the treatment of cancer.Type: GrantFiled: September 7, 2011Date of Patent: May 6, 2014Assignee: Hoffmann-La Roche Inc.Inventors: Lei Guo, Guozhi Tang, Zhanguo Wang, Jason Christopher Wong, Weixing Zhang
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Patent number: 8710233Abstract: The present invention relates to novel vanilloid receptor ligands, to a process for the production thereof, to pharmaceutical preparations containing these compounds and to the use of these compounds for the production of pharmaceutical preparations.Type: GrantFiled: October 19, 2006Date of Patent: April 29, 2014Assignee: Gruenenthal GmbHInventors: Jeewoo Lee, Hyung Chul Ryu, Robert Frank, Gregor Bahrenberg, Jean De Vry, Thomas Christoph, Derek John Saunders, Klaus Schiene, Bernd Sundermann
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Publication number: 20140113899Abstract: An agro-horticultural agent of the present invention is intended to provide an agro-horticultural agent capable of providing, with a smaller spray amount, the same effect as compared to a conventional agro-horticultural agent. The agro-horticultural agent of the present invention includes a plurality of active ingredients and one of the plurality of active ingredients is an azole derivative represented by the following general formula (I); where: Ra and Rb each represent a predetermined hydrocarbon group and at least one of Ra and Rb has a chlorine atom or a bromine atom substituted for a hydrogen atom; Y represents a chlorine atom or a fluorine atom; and m represents 0 or 1.Type: ApplicationFiled: June 6, 2012Publication date: April 24, 2014Applicant: KUREHA CORPORATIONInventors: Hideaki Tateishi, Nobuyuki Araki, Toru Yamazaki, Taiji Miyake, Keiichi Sudo, Hisashi Kanno
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Publication number: 20140106003Abstract: The present specification provides compositions comprising a thioxanthone-based autophagy inhibitor and/or a cancer therapeutic autophagy inducing compound, pharmaceutical kits comprising these compositions, and methods of treating cancer using such compounds, compositions and kits. Additionally, the present specification provides methods of treating cancer using a thioxanthone-based autophagy inhibitor and a radiotherapy.Type: ApplicationFiled: August 6, 2013Publication date: April 17, 2014Applicant: SPECTRUM PHARMACEUTICALS, INC.Inventors: Steffan Nawrocki, Jennifer Carew, Guru Reddy
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Publication number: 20140100537Abstract: The present invention provides a titratable transdermal drug delivery system comprising an effective dose of an antithrombotic agent, such as tirofiban, or a pharmaceutically acceptable salt thereof. The dosage of the drug delivered is proportional to the size of the patch applied and achieves 60-85% platelet inhibition. The system enables and individualized treatment for patients. Also provided are methods for the treatment of various disorders where platelet inhibition is desired.Type: ApplicationFiled: December 11, 2013Publication date: April 10, 2014Applicant: MEDICURE INTERNATIONAL INC.Inventors: George Roby THOMAS, Dawson James REIMER, Albert D. FRIESEN
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Publication number: 20140100107Abstract: The present invention relates to active compound combinations, in particular within a fungicide composition, which comprises (A) a dithiino-tetracarboximide of formula (I), (B) an inhibitor of the respiratory chain at complex I or II and (C1) an inhibitor of the ergosterol biosynthesis, in particular an azole compound, or (C2) an inhibitor of the respiratory chain at complex III, in particular a strobilurin compound. Moreover, the invention relates to a method for curatively or preventively controlling the phytopathogenic fungi of plants or crops, to the use of a combination according to the invention for the treatment of seed, to a method for protecting a seed and not at least to the treated seed.Type: ApplicationFiled: March 28, 2012Publication date: April 10, 2014Applicant: BAYER INTELLECTUAL PROPERTY GMBHInventors: Ulrike Wachendorff-Neumann, Ingo Wetcholowsky, Anton Kraus, Thomas Seitz, Jose Augusto Geraldes
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Patent number: 8691812Abstract: A composition comprising a carboxamide compound represented by following formula (I), wherein R1 represents a hydrogen atom or a methyl group, and R2 represents a methyl group, a difluoromethyl group or a trifiuoromethyl group, and one or more neonicotinoid compound selected from group (A) consisting of acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram thiacloprid and thiamethoxam possesses an excellent pesticidal effect.Type: GrantFiled: April 25, 2011Date of Patent: April 8, 2014Assignee: Sumitomo Chemical Company, LimitedInventor: Yuichi Matsuzaki
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Publication number: 20140093577Abstract: The present invention includes compositions and methods for the controlled release of active agents in a shelf-stable liquid formulation by blending one or more controlled release microbeads comprising one or more active agents, preparing a dense, thixotropic solution having a density that is at, or about, the density of the one or more microbeads comprising a thixotropic agent, water and one or more preservatives under conditions that reduce bubble formation and mixing the microbeads and the thixotropic solutions in a mixer that lacks scraping paddles.Type: ApplicationFiled: October 3, 2013Publication date: April 3, 2014Applicant: NEOS THERAPEUTICS, LPInventors: Mark TENGLER, Paul Taskey, Daniel Lockhart, Russell McMahen
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Publication number: 20140094455Abstract: Compounds, including 3-carboxy aryl sulfonamide compounds, which agonize or antagonize aquaporin channels and methods of using them to treat disorders or diseases mediated by aquaporins.Type: ApplicationFiled: August 19, 2013Publication date: April 3, 2014Applicant: ARIZONA BOARD OF REAGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONAInventors: Gary A. Flynn, Andrea J. Yool, Elton Rodrigues Migliati, Leslie S. Ritter
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Publication number: 20140094492Abstract: Derivatives of sulindac that lack cyclooxygenase inhibitory activity are provided along with pharmaceutical compositions containing them and use for treatment or prevention of cancer. The derivatives of sulindac are also suitable for treating chronic inflammatory conditions. A method for preparing the derivatives is also provided.Type: ApplicationFiled: March 30, 2012Publication date: April 3, 2014Applicant: Southern Research InstituteInventors: Robert Reynolds, Bini Mathew, Gary A. Piazza
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Publication number: 20140093513Abstract: The invention relates to new methods of modulating cholesterol by inhibiting proprotein convertase subtilisin/kexin type 9 (PCSK9) with fatty acid derivatives; and new methods for treating or preventing a metabolic disease comprising the administration of an effective amount of a fatty acid derivative. The present invention is also directed to fatty acid bioative derivatives and their use in the treatment of metabolic diseases.Type: ApplicationFiled: May 24, 2013Publication date: April 3, 2014Applicant: Catabasis Pharmaceuticals, Inc.Inventors: Jill C. Milne, Michael R. Jirousek, Chi B. Vu
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Patent number: 8686006Abstract: An object of the present invention is to provide a pharmaceutical composition that improves intestinal absorption of a compound having a structure represented by the general formula [1]. The composition containing a compound represented by the general formula [1] or a salt thereof and (b) a lipophilic substance improves intestinal absorption of the compound. In the formula, A represents —(NR4)—, —(CR5R6)— or the like; B represents an alkylene group or an alkenylene group; R1 represents an alkyl group, an alkenyl group or the like; R2 represents an adamantylalkyl group or the like; R3 represents an unsaturated heterocyclic ring; R4, R5 and R6 each represent a hydrogen atom or the like; and X represents an oxygen atom or the like.Type: GrantFiled: October 22, 2009Date of Patent: April 1, 2014Assignee: Santen Pharmaceutical Co., Ltd.Inventors: Masayuki Umeda, Akio Kimura, Kenji Ueda, Koji Sakanaka
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Patent number: 8685423Abstract: The invention disclosed in this document concerns controlling mealybugs.Type: GrantFiled: January 27, 2012Date of Patent: April 1, 2014Assignee: Dow AgroSciences, LLC.Inventors: Mayank Yadav, Suresh Ramachandran, Sanjoy Kundu
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Publication number: 20140088148Abstract: Small molecule inhibitors of XBP1 splicing by IRE1 are provided, as well as methods for their use in treating or preventing cancer (e.g., endocrine resistant breast cancer), diabetes, and obesity.Type: ApplicationFiled: April 4, 2012Publication date: March 27, 2014Applicant: GEORGETOWN UNIVERSITYInventors: Sivanesan Dakshanamurthy, Milton L. Brown, Robert Clarke, Ayesha N. Shahjahan, Jaqueline Smith
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Publication number: 20140088046Abstract: The present invention provides novel phenicol derivatives, their use for the treatment of infections in mammals, pharmaceutical composition containing these novel compounds, and methods for the preparation of these compounds.Type: ApplicationFiled: September 5, 2013Publication date: March 27, 2014Applicant: ZOETIS LLCInventors: Denis Billen, Michael Curtis, Richard Andrew Ewin, Richard M. Goodwin, Paul D. Johnson, Timothy Allan Johnson, Graham M. Kyne, Todd M. Maddux, Susan Mary Kult Sheehan, Rajendran Vairagoundar
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Publication number: 20140088092Abstract: The present invention relates to the use of active substance combinations for controlling animal pests, for example, from the chinch bug family (Lygaeidae), as well as animal pests that has shown resistance to pyrethroids.Type: ApplicationFiled: March 8, 2013Publication date: March 27, 2014Applicant: Bayer CropScience LPInventors: Jeffrey A. MICHEL, Kenneth A. KUKOROWSKI
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Publication number: 20140088157Abstract: Provided are an endoparasite control agent comprising a carboxamide derivative represented by the general formula (I): or a salt thereof as an active ingredient, and a method for controlling endoparasites, comprising orally or parenterally administering the endoparasite control agent.Type: ApplicationFiled: March 1, 2012Publication date: March 27, 2014Applicants: NIHON NOHYAKU CO., LTD., THE UNIVERSITY OF TOKYOInventors: Kiyoshi Kita, Akiyuki Suwa
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Publication number: 20140080800Abstract: The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, wherein U, J, V, X, R2a, R2b, R2c, R5 and t are as described herein. The present invention relates generally to inhibitors of histone deacetylase and to methods of making and using them. These compounds are useful for promoting cognitive function and enhancing learning and memory formation. In addition, these compounds are useful for treating, alleviating, and/or preventing various conditions, including for example, neurological disorders, memory and cognitive function disorders/impairments, extinction learning disorders, fungal diseases and infections, inflammatory diseases, hematological diseases, and neoplastic diseases in humans and animals.Type: ApplicationFiled: October 28, 2013Publication date: March 20, 2014Inventors: Edward Holson, Florence Fevrier Wagner, Michel Weiwer, Li-Huei Tsai, Stephen Haggarty, Yan-Ling Zhang
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Publication number: 20140080820Abstract: The invention relates to novel fungicidally active compound combinations of 2?-cyano-3,4-dichloroisothiazole-5-carboxanilide of the formula and active compounds listed in the disclosure.Type: ApplicationFiled: November 19, 2013Publication date: March 20, 2014Applicant: BAYER CROPSCIENCE AGInventors: Peter DAHMEN, Ulrike WACHENDORFF-NEUMANN, Rolf PONTZEN, Wolfram ANDERSCH, Lutz ASSMANN
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Publication number: 20140080775Abstract: The present invention is directed toward a method of treating a subject for a condition mediated by aberrant Wnt/?-catenin signaling by selecting a subject with a condition mediated by aberrant Wnt/?-catenin signaling and administering to the selected subject at least one compound selected from the group consisting of those set forth in Table 1, Table 2, Table 3, and a pharmaceutically acceptable salt thereof. A method of similarly modulating the Wnt/?-catenin pathway in a subject is also discussed.Type: ApplicationFiled: November 18, 2013Publication date: March 20, 2014Applicants: UNIVERSITY OF WASHINGTON, The General Hospital Corporation, MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: Randall T. Moon, Travis L. Biechele, Nathan D. Camp, Stephen Haggarty, Daniel Fass
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Publication number: 20140080803Abstract: Disclosed herein are modulators of TRPV3 of Formula (I) wherein p is 1, 2, 3, or 4, and G1, X1, X2, X3, X4, X5, G2, Z1, Ra, Rb, and u are as defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also presented.Type: ApplicationFiled: October 23, 2012Publication date: March 20, 2014Applicant: AbbVie Inc.Inventors: Erol K. Bayburt, Bruce Clapham, Phil B. Cox, Jerome F. Daanen, Michael J. Dart, Gregory A. Gfesser, Arthur Gomtsyan, Michael E. Kort, Philip R. Kym, Robert G. Schmidt, Eric A. Voight
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Patent number: 8673946Abstract: This invention relates to novel 4-trimethylammoniobutyrates of the formula wherein A1, R1, m and n are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds inhibit carnitine palmitoyl transferase (CPT) activity, in particular CPT2 activity, and can be used as medicaments.Type: GrantFiled: October 5, 2012Date of Patent: March 18, 2014Assignee: Hoffmann-La Roche Inc.Inventors: Mirjana Andjelkovic, Simona M. Ceccarelli, Odile Chomienne, Patrizio Mattei
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Patent number: 8673918Abstract: The present invention relates to stable compositions comprising a sphingosine 1 phosphate (S1P) receptor modulator, suitable for use as a dosage form. The S1P receptor modulators are typically sphingosine analogues, such as 2-substituted 2-amino-propane-1,3-diol or 2-amino-propanol derivatives, e.g. a compound comprising a group of formula Y.Type: GrantFiled: October 9, 2008Date of Patent: March 18, 2014Assignee: Novartis AGInventors: Colleen Ruegger, Michael Ambühl
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Patent number: 8673903Abstract: The present application relates to novel substituted 8-alkoxy-2-aminotetraline derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders.Type: GrantFiled: May 9, 2011Date of Patent: March 18, 2014Assignee: Bayer Intellectual Property GmbHInventors: Walter Hübsch, Michael Hahn, Alexandros Vakalopoulos, Volkhart Min-Jian Li, Frank Wunder, Johannes-Peter Stasch, Karl-Heinz Schlemmer, Friederike Stoll, Niels Lindner
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Patent number: 8669278Abstract: N-Substituted (6-haloalkylpyridin-3-yl)alkyl sulfoximines are effective at controlling insects.Type: GrantFiled: July 26, 2012Date of Patent: March 11, 2014Assignee: Dow AgroSciences, LLC.Inventors: Michael R. Loso, Benjamin M. Nugent, Jim X. Huang, Richard B. Rogers, Yuanming Zhu, James M. Renga, Vidyadhar B. Hegde, Joseph J. DeMark
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Publication number: 20140057787Abstract: Coating composition for soya bean seed from which roots and shoots are capable of growing, wherein the coating composition comprises an organic carrier material and one or more biological agents that possess an activity against at least one or more pathogens of the soybean plant.Type: ApplicationFiled: April 19, 2012Publication date: February 27, 2014Applicant: EXOSECT LIMITEDInventor: Nicholas Hugh Hylton Jessop
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Patent number: 8658677Abstract: Compounds are provided according to formula I: where R, R?, R3, R4, R5, and R6 are as defined herein. Provided compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, Alzheimer's Disease, Down's syndrome, Parkinson's Disease, and others.Type: GrantFiled: July 6, 2012Date of Patent: February 25, 2014Assignees: Aria Neurosciences Inc., New York UniversityInventors: Bijan Almassian, Martin J. Sadowski, Xu Kevin Lin
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Publication number: 20140051576Abstract: The present invention relates to active compound combinations, in particular within an insecticide or fungicide composition, which comprises (A) a N-cyclopropyl-N-[substituted-benzyl]-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide or thiocarboxamide derivative and a further insecticidally and/or acaricidally and/or nematicidal active compound (B). Moreover, the invention relates to a method for controlling animal pests such as insects and/or unwanted acarids and/or nematodes, to the use of a combination according to the invention for the treatment of seed, to a method for protecting a seed and not at least to the treated seed.Type: ApplicationFiled: April 18, 2012Publication date: February 20, 2014Inventors: Peter Dahmen, Philippe Desbordes, Christophe Dubost, Stephanie Gary, Elke Hellwege, Hendrik Helmke, Heike Hungenberg, Ulrike Wachendorff-Neumann
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Publication number: 20140044806Abstract: The present invention relates to compounds useful in therapy, to compositions comprising said compounds, and to methods of treating diseases comprising administration of said compounds. The compounds referred to are positive allosteric modulators (PAMs) of the nicotinic acetylcholine ?7 receptor.Type: ApplicationFiled: October 16, 2013Publication date: February 13, 2014Applicant: H. Lundbeck A/SInventors: Jørgen Eskildsen, Anette Graven Sams, Ask Püschl
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Publication number: 20140044774Abstract: The present invention generally relates to the transdermal delivery of various compounds. In some aspects, transdermal delivery may be facilitated by the use of a hostile biophysical environment. One set of embodiments provides a composition for topical delivery comprising an H1 antihistamine and/or a salt thereof, and optionally, a hostile biophysical environment and/or a nitric oxide donor. In some cases, the composition may be stabilized using a combination of a stabilization polymer (such as xanthan gum, KELTROL® BT and/or KELTROL® RD), propylene glycol, and a polysorbate surfactant such as Polysorbate 20, which combination unexpectedly provides temperature stability to the composition, e.g., at elevated temperatures such as at least 40° C. (at least about 104° F.), as compared to compositions lacking one or more of these.Type: ApplicationFiled: December 29, 2011Publication date: February 13, 2014Applicant: Strategic Science & Technologies, LLCInventor: Eric T. Fossel
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Patent number: 8648101Abstract: The present invention provides a nematocide containing, as an active ingredient, an N-2-(pyridyl)ethylcarboxamide derivative represented by the formula (I): wherein Ar is a substituted phenyl group having one or more, the same or different substituents selected from a halogen atom, a (C1-C6)alkyl group, a halo(C1-C6)alkyl group, a (C1-C6)alkylthio group, a halo(C1-C6)alkylthio group, a (C1-C6)alkoxy group and a halo(C1-C6)alkoxy group, and the like, X may be the same or different, and is a hydrogen atom, a halogen atom, a (C1-C6)alkyl group, a halo(C1-C6)alkyl group, and the like, and n is the integer 0 to 4, or a salt thereof, and a method of controlling nematodes, including applying the above compound. The present invention can provide a nematocide or a method of controlling nematodes that exerts a reduced impact on the global environment, exhibits a broad nematode control spectrum at low application rates, and has an excellent nematode control effect.Type: GrantFiled: April 11, 2008Date of Patent: February 11, 2014Assignee: Nihon Nohyaku Co., Ltd.Inventor: Akiyuki Suwa
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Patent number: 8648102Abstract: The present invention concerns compounds and their use to treat cell proliferative diseases such as cancer. Compounds of the present invention display significant potency as kinase inhibitors, cause the downregulation of c-myc, and inhibit the growth and survival of cancerous cell lines.Type: GrantFiled: January 13, 2012Date of Patent: February 11, 2014Assignee: Board of Regents, The University of Texas SystemInventors: Waldemar Priebe, Nicholas Donato, Moshe Talpaz, Slawomir Szymanski, Izabela Fokt, Alexander Levitzki
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Patent number: 8648203Abstract: The present invention relates to an improved process for the synthesis and purification of 3-chloro-N-(3-chloro-5-tri-fluoromethyl-2-pyridyl)-?,?,?-trifluoro-2,6-di-nitro-p-toluidine (fluazinam) and other pyridinamines, which implements methyl isobutyl ketone (MIBK) as the reaction solvent. The process of the invention overcomes the drawbacks of prior art methods, by reducing the side reactions such as hydrolysis, eliminating the need for difficult and labor-intensive purification methods, and providing pure products in higher yields. The present invention relates to novel crystalline polymorphic forms fluazinam, and to mixtures of the polymorphs. The present invention also provides methods for preparing the novel polymorphs, as well as pharmaceutical compositions comprising same, and methods of using the polymorphs as pesticidal agents for combating noxious living organisms on agricultural and horticultural crops.Type: GrantFiled: April 11, 2012Date of Patent: February 11, 2014Assignee: Makhteshim Chemical Works Ltd.Inventors: Shlomi Cohen, Sharona Zamir
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Publication number: 20140038823Abstract: The present invention relates to active compound combinations, in particular within a fungicide composition, which comprises (A) a N-cyclopropyl-N-[substituted-benzyl]-3-(difluoromethyl)-5-fluoro-1-methyl-1H-pyrazole-4-carboxamide or thiocarboxamide derivative and a further fungicidally active compound (B). Moreover, the invention relates to a method for curatively or preventively or eradicatively controlling the phytopathogenic fungi of plants or crops, to the use of a combination according to the invention for the treatment of seed, to a method for protecting a seed and not at least to the treated seed.Type: ApplicationFiled: April 18, 2012Publication date: February 6, 2014Inventors: Peter Dahmen, Philippe Desbordes, Christophe Dubost, Stephanie Gary, Frank Goehlich, Hendrik Helmke, Thomas Seitz, Ulrike Wachendorff-Neumann, Ingo Wetcholowsky
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Patent number: 8642775Abstract: Vanilloid receptor ligand compounds corresponding to formula I: a process for producing such compounds, pharmaceutical compositions containing them, and the use of such compounds to treat pain and various other vanilloid receptor mediated conditions.Type: GrantFiled: April 15, 2008Date of Patent: February 4, 2014Assignee: Gruenenthal GmbHInventors: Robert Frank, Gregor Bahrenberg, Thomas Christoph, Klaus Schiene, Jean De Vry, Derek Saunders, Michael Przewosny, Bernd Sundermann, Jewoo Lee
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Patent number: 8642631Abstract: The invention relates to methods of medically treating mammals with Eustachian tube dysfunctions, such as Ménière's disease, vertigo, Otitis Media (including Otitis Media with Effusion (OME), Acute Otitis Media (AOM) and Aerotitis Media (AM)) as well as other disorders which are characterized by ET dysfunction.Type: GrantFiled: May 27, 2009Date of Patent: February 4, 2014Assignee: University of MelbourneInventors: Colin Russell Anderson, Burkhard Franz
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Patent number: RE44874Abstract: The present invention relates to novel compounds of formula (I), to a process for their manufacture, to pharmaceutical compositions containing them, and to their use in therapy, in particular their use in the prophylaxis and treatment of respiratory diseasesType: GrantFiled: December 19, 2012Date of Patent: April 29, 2014Assignee: Glaxo Group LimitedInventors: Philip Charles Box, Diane Mary Coe, Brian Edgar Looker, Panayiotis Alexandrou Procopiou