Plural Ring Chalcogens In The Hetero Ring Patents (Class 514/360)
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Publication number: 20110288136Abstract: Disclosed herein are compounds, compositions and methods for treating or ameliorating flavivirus infections. This is particularly important because the present disclosure provides methods for treating flavivirus infections for which there is no effective vaccine.Type: ApplicationFiled: July 18, 2011Publication date: November 24, 2011Inventor: Eric Barklis
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Patent number: 8022032Abstract: The method set out herein involves identifying the concentration of each of two or more active therapeutics tailored to treat a particular patient's unique metabolism and one or more diseases, communicating that information to a producer who has multiple fixed or variable concentrations of each active available, where the producer then combines the individual concentrations of each active into single units such as a tablets or pills, and distributes those indirectly or directly to the patient.Type: GrantFiled: November 18, 2005Date of Patent: September 20, 2011Assignee: SmithKline Beecham CorporationInventors: Richard L. Kirsh, Steven D. Finkelmeier, Robert Glinecke, Luigi Martini
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Publication number: 20110207781Abstract: Compounds of Formula (I), in which the substituents are as defined in claim 1, are suitable for use as microbiocides.Type: ApplicationFiled: June 9, 2009Publication date: August 25, 2011Applicant: SYNGENTA CROP PROTECTION, INC.Inventors: Daniel Stierli, Harald Walter, Sebastian Wendeborn, Antoine Daina
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Patent number: 8002883Abstract: Use of compositions comprising a) at least one azole and b) at least one amidoalkylamine of the formula (I), a salt and/or acid addition compound thereof, in which R1 represents optionally substituted C1-C40-alkyl or C2-C40-alkenyl, R2, R3 and R4 independently of one another represent hydrogen or C1-C8-alkyl and n represents an integer from 1 to 6 for protecting industrial materials against attack and/or destruction by microorganisms.Type: GrantFiled: June 3, 2010Date of Patent: August 23, 2011Assignee: LANXESS Deutschland GmbHInventors: Bernd Koop, Martin Kugler, Andreas Böttcher, Johannes Kaulen
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Patent number: 8003674Abstract: Disclosed herein are compounds, compositions and methods for treating or ameliorating flavivirus infections. This is particularly important because the present disclosure provides methods for treating flavivirus infections for which there is no effective vaccine.Type: GrantFiled: March 15, 2007Date of Patent: August 23, 2011Assignee: Oregon Health & Science UniversityInventor: Eric Barklis
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Patent number: 8003649Abstract: The invention concerns bicyclic compounds of Formula I wherein the integers X1, X2, X3, Ring A, R4, R5 and m are as defined in the description. The present invention also relates to processes for the preparation of such compounds, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the prevention or treatment of androgen-receptor associated conditions.Type: GrantFiled: December 18, 2008Date of Patent: August 23, 2011Assignee: AstraZeneca ABInventors: Robert Hugh Bradbury, Alfred Arthur Rabow, Neil James Hales
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Patent number: 7977368Abstract: The invention provides compounds of Formula I wherein A, Y, R1, R1a, R2, and R2a are as described in the specification. Compounds of Formula I are useful in treating and/or preventing cognitive disorders, such as Alzheimer's disease. The invention also encompasses pharmaceutical compositions comprising compounds of Formula I, methods of preparing compounds of Formula I, and methods of treating cognitive disorders, such as Alzheimer's disease.Type: GrantFiled: May 21, 2008Date of Patent: July 12, 2011Assignee: Elan Pharmaceuticals, Inc.Inventors: Darren Dressen, Simeon Bowers, Albert W. Garofalo, Roy K. Hom, Matthew N. Mattson
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Patent number: 7968543Abstract: Provided herein are methods of administering N-(5-tert-butyl-isoxazol-3-yl)-N?-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea, or a pharmaceutically acceptable salt or solvate thereof, to human patients. Specifically, dosing, dosing schedules or dosing regimens are provided herein. Further, pharmaceutical formulations are provided. Methods of treating proliferative diseases or FLT-3 mediated diseases in humans are also provided.Type: GrantFiled: November 7, 2008Date of Patent: June 28, 2011Assignee: Ambit Biosciences CorporationInventors: Joyce K. James, Traci L. Savall, Shawn R. Eichelberger
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Publication number: 20110118274Abstract: The present invention relates to proteasome inhibitors and their use in methods of treating a subject for a pathogen infection or cancer. The methods involve administering to the subject a compound of Formula (I). (I) where: Q is Formula or Formula, where the crossing dashed line illustrates the bond formed joining Q to the rest of the compound of Formula (I). The remainder of substituents of the compound of Formula (I) are defined in the present application.Type: ApplicationFiled: August 25, 2008Publication date: May 19, 2011Applicant: CORNELL RESEARCH FOUNDATION, INC.Inventors: Carl Nathan, Gang Lin
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Patent number: 7910606Abstract: The present invention is directed to a compound of formula I, in which R0; R1; R2; R3; R4; Q; V, G and M have the meanings indicated below. The compound of formula I is a pharmacologically active compound. It exhibits a strong anti-thrombotic effect and is suitable, for example, for the therapy and prophylaxis of a cardio-vascular disorder like a thromboembolic disease or restenosis. It is a reversible inhibitor of the blood clotting enzymes factor Xa (FXa) and/or factor VIIa (FVIIa), and can in general be applied in conditions in which an undesired activity of factor Xa and/or factor VIIa is present or for the cure or prevention of which an inhibition of factor Xa and/or factor VIIa is intended. The invention furthermore is directed to a process for the preparation of the compound of formula I, and pharmaceutical preparation comprising it.Type: GrantFiled: September 18, 2009Date of Patent: March 22, 2011Assignee: Sanofi-Aventis Deutschland GmbHInventors: Marc Nazare, Volkmar Wehner, David William Will, Hans Matter
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Publication number: 20110046090Abstract: The instant disclosure describes methods for treating diseases and conditions of the central and peripheral nervous system by stimulating or increasing neurogenesis. The disclosure includes compositions and methods based on use of a GABA agent or GABA analog, in combination with one or more other neurogenic agents, to stimulate or activate the formation of new nerve cells.Type: ApplicationFiled: August 20, 2010Publication date: February 24, 2011Applicant: BrainCells Inc.Inventors: Carrolee BARLOW, Todd Carter, Andrew Morse, Kai Treuner, Kym Lorrain, Jammieson Pires
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Patent number: 7893096Abstract: The invention provides immunostimulatory compositions comprising a small molecule immuno-poteniator (SMIP) compound and methods of administration thereof. Also provided are methods of administering a SMIP compound in an effective amount to enhance the immune response of a subject to an antigen. Further provided are novel compositions and methods of administering SMIP compounds alone or in combination with another agent for the treatment of cancer, infectious diseases and/or allergies/asthma.Type: GrantFiled: March 29, 2004Date of Patent: February 22, 2011Assignee: Novartis Vaccines and Diagnostics, Inc.Inventor: Nicholas M. Valiante, Jr.
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Patent number: 7875644Abstract: Compounds of the formula (I), in which R1, R2, R3a, R3b, R3c and R3d have the meanings indicated in claim 1, are inhibitors of tyrosine kinases, in particular Met kinase, and can be employed, inter alia, for the treatment of tumours.Type: GrantFiled: July 18, 2006Date of Patent: January 25, 2011Assignee: Merck Patent GmbHInventors: Dieter Dorsch, Oliver Schadt, Andree Blaukat
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Publication number: 20100331330Abstract: A method of treating a cerebrovascular accident in a subject includes administering a therapeutically effective amount of at least one PPAR? agonist or a derivative thereof to the subject after onset of ischemia sufficient to a cause the cerebrovascular accident and prior to reperfusion.Type: ApplicationFiled: August 21, 2007Publication date: December 30, 2010Inventors: Gary E. Landerth, Sophia Sundararajan, Colin Combs
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Publication number: 20100292239Abstract: Compounds of the formula (I), in which the substituents are as defined in claim 1 are suitable for use as microbiocides.Type: ApplicationFiled: July 24, 2008Publication date: November 18, 2010Applicant: SYNGENTA CROP PROTECTION, INC.Inventors: Daniel Stierli, Antoine Daina, Harald Walter, Hans Tobler, Ramya Rajan
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Publication number: 20100234434Abstract: Disclosed herein are compounds, compositions and methods for treating or ameliorating flavivirus infections. This is particularly important because the present disclosure provides methods for treating flavivirus infections for which there is no effective vaccine.Type: ApplicationFiled: March 15, 2007Publication date: September 16, 2010Inventor: Eric Barklis
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Patent number: 7790738Abstract: The present invention provides a method of treating or preventing a disorder typified by an immunodificiency (e.g. HIV), wherein the patient is administered a COX-2 inhibitor or derivative or pharmaceutically acceptable salt thereof, preferably diisopropylfluorophasphate. L-745337, rofecoxib, NS 398, SC 58125, etodolac, meloxicam, celecoxib or nimesulide, and compositions and products containing the same or use of the same in preparing medicaments and for treatment.Type: GrantFiled: July 20, 2001Date of Patent: September 7, 2010Assignee: Lauras ASInventors: Kjetil Taskén, Michel Moutschen, Souad Rahmouni-Piette, Einar Martin Aandahl, Pål Aukrust, Stig S. Frøland, Christian C. Johansson, Vidar Hansson, Jo Klaveness
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Patent number: 7786151Abstract: The present invention provides a composition of treating, preventing abnormal splicing caused by the excessive kinase induction, which comprises TG003 and a method using the same of treating, preventing abnormal splicing caused by the excessive kinase induction.Type: GrantFiled: January 6, 2005Date of Patent: August 31, 2010Assignee: KinoPharma, Inc.Inventors: Masatoshi Hagiwara, Masaaki Suzuki
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Publication number: 20100216689Abstract: Disclosed is a substance which has a low molecular weight, can be applied in a simpler manner, and has an immunopotentiating activity against cancer and/or a microorganism-mediated infectious disease. An EP4 agonist exhibits an immunopotentiating activity through the activation of a cytotoxic T cell, and is therefore useful for the prevention and/or treatment of cancer or a microorganism-mediated infection disease.Type: ApplicationFiled: May 7, 2008Publication date: August 26, 2010Applicants: ONO PHARMACEUTICAL CO., LTD.Inventors: Masahiro Takigawa, Naohiro Seo, Kenji Kabashima, Takayuki Maruyama, Toshiya Kanaji
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Patent number: 7781466Abstract: The invention relates to a preservative comprising at least one isothiazolone, at least one quaternary ammonium compound, and at least one stabilizer selected from the group of sulphite salts, hydrogen sulphite salts, sulphite-releasing compounds and hydrogen-sulphite-releasing compounds, the presence of algicidal triazine being ruled out. The preservative inhibits the growth of fungi, algae and bacteria on or in alkaline coating compositions. The invention furthermore relates to a process for the preparation of the preservative, to its use in a coating composition, and to the preserved composition.Type: GrantFiled: September 21, 2006Date of Patent: August 24, 2010Assignee: Air Liquide Sante (International)Inventors: Petra Kolditz, Klaus Weber, Ralf Gradtke, Wolfgang Beilfuss
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Patent number: 7750030Abstract: Methods for treating an individual with a psychiatric order with a pharmacologic agent that enhances learning or conditioning in combination with a session of psychotherapy are provided. These methods of the invention encompass a variety of methods of psychotherapy, and psychodynamically oriented psychotherapy, and psychiatric orders including fear and anxiety disorders, addictive disorders, addictive disorders including substance-abuse disorders, and mood disorders. The pharmacologic agents used for the methods of the present invention are ones that generally enhance learning or conditioning, including those that increase the level of norepinephrine in the brain, those that increase the level of acetylcholine in the brain, and those that enhance N-methyl-D-aspartate (NMDA) receptor transmission in the brain.Type: GrantFiled: March 28, 2002Date of Patent: July 6, 2010Inventors: Michael Davis, Kerry J. Ressler
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Publication number: 20100168189Abstract: Therapeutic compounds, compositions, methods, and medicaments related thereto are disclosed herein.Type: ApplicationFiled: February 8, 2008Publication date: July 1, 2010Inventors: David W. Old, Wha Bin Im, Vinh X. Ngo
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Publication number: 20100130564Abstract: Provided are methods of inhibiting BCL6 repression in a mammalian cell. Also provided are methods of treating cancer in a mammal.Type: ApplicationFiled: November 29, 2007Publication date: May 27, 2010Inventors: Ari Matthew Melnick, Alexander D. MacKerell, JR., Gilbert Gerard Privé
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Patent number: 7678789Abstract: The present invention relates to 5-imino-5H-[1,2,4]-dithiazol-3-yl-amine and [1,2,4]-dithiazolidine-3,5-diylidene-diamine derivatives as inducers of gluthathione-S-transferase (GST) and NADPH quinone oxidoreductase (NQO), to methods for the preparation of these compounds and to novel intermediates useful for the synthesis of said [1,2,4]-dithiazoli(di)ne derivatives. The invention also relates to the use of a compound disclosed herein for the treatment of adverse conditions associated with cytotoxicity in general and apoptosis in particular. The invention relates to compounds of the general formula (I): wherein wherein the symbols have the meanings given in the specification.Type: GrantFiled: February 9, 2006Date of Patent: March 16, 2010Assignee: Solvay Pharmaceuticals B.V.Inventors: Roelof W. Feenstra, Hiskias G. Keizer, Maria L. Pras-Raves, Bernard J Van Vliet, Gustaaf J. M. Van Scharrenburg
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Patent number: 7670416Abstract: A combination of selected substances in paint to prevent the settlement and growth of different bio-fouling organisms with a reduced negative effect on the ecosystems compared to present methods. Useful substances include medetomidine with various copper and zinc formulations, tolylfluanide, diclofluanide, DIURON™ and IRGAROL™, or more general biocides such as SEANINE™ (4,5-dichloro-2-n-octyl-3(2H)-isothiazolone) or ECONEA™ (2-(p-chlorophenyl)-3-cyano-4-bromo-5-trifluoromethyl pyrrole).Type: GrantFiled: August 1, 2006Date of Patent: March 2, 2010Inventor: Lena Mårtensson
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Publication number: 20100022600Abstract: A method of treating a central nervous system tumor in a subject includes administering a therapeutically effective amount of at least one PPAR? agonist or a derivative thereof to the tumor in the subject.Type: ApplicationFiled: August 28, 2007Publication date: January 28, 2010Inventors: Gary E. Landreth, Christian Grommes
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Publication number: 20100010045Abstract: The present invention is directed to a compound of formula I, in which R0; R1; R2; R3; R4; Q; V, G and M have the meanings indicated below. The compound of formula I is a pharmacologically active compound. It exhibits a strong anti-thrombotic effect and is suitable, for example, for the therapy and prophylaxis of a cardio-vascular disorder like a thromboembolic disease or restenosis. It is a reversible inhibitor of the blood clotting enzymes factor Xa (FXa) and/or factor VIIa (FVIIa), and can in general be applied in conditions in which an undesired activity of factor Xa and/or factor VIIa is present or for the cure or prevention of which an inhibition of factor Xa and/or factor VIIa is intended. The invention furthermore is directed to a process for the preparation of the compound of formula I, and pharmaceutical preparation comprising it.Type: ApplicationFiled: September 18, 2009Publication date: January 14, 2010Applicant: sanofi-aventis Deutschland GmbHInventors: Marc NAZARE, Volkmar WEHNER, David W. WILL, Hans MATTER
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Patent number: 7635708Abstract: The present invention is based on the finding that activation of PPAR? plays a key role in inducing growth arrest and differentiation of certain actively proliferating cells. We show that administration of PPAR? agonists, such as thiazolidinedione ligands (TZDs), is effective both in vitro and in vivo at inhibiting the proliferation of such cells.Type: GrantFiled: December 19, 2002Date of Patent: December 22, 2009Assignee: Dana-Farber Cancer InstituteInventors: Bruce M. Spiegelman, Elisabetta Mueller, Pasha Sarraf, Soner Altiok, Peter Tontonoz, Samuel Singer
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Publication number: 20090239914Abstract: The present invention relates to oral compositions which are useful for binding phosphorus in ingesta, and inhibiting absorption of phosphorus from the gastrointestinal tract of subjects. A method for binding phosphorus in ingesta and inhibiting its absorption from the gastrointestinal tract is also provided. The dietary supplements and pharmaceutical products and methods of the present invention are particularly useful in the treatment of hyperphosphatemia of chronic uremia and reducing serum phosphorus levels in patients requiring such therapy.Type: ApplicationFiled: March 20, 2008Publication date: September 24, 2009Inventor: Deanna Jean Nelson
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Patent number: 7582664Abstract: The invention relates to a compound of formula (I): Wherein R1, R2, R2?, R3, R4 and R5 are as defined herein. The invention also relates to the use of said compound in therapeutics.Type: GrantFiled: July 7, 2006Date of Patent: September 1, 2009Assignee: Sanofi-AventisInventors: Sylvie Baltzer, Viviane Van Dorsselaer
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Publication number: 20090170910Abstract: The present invention relates to the use of p38 MAP kinase inhibitors and p38 MAP kinase inhibition to promote wound healing.Type: ApplicationFiled: August 31, 2005Publication date: July 2, 2009Inventor: Stephen M. Gunnigle
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Publication number: 20090156546Abstract: The present invention provides methods and compositions for the prophylaxis of blood cell disorders such as neutropenia, thrombocytopenia, lymphocytopenia, and anaemia. The invention provides methods wherein compositions comprising at least one cytokinin compound are administered either therapeutically or prophylactically. The invention further has utility in methods of DNA repair.Type: ApplicationFiled: May 11, 2007Publication date: June 18, 2009Inventor: Patrick T. Prendergast
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Publication number: 20090118337Abstract: A method of treating a subject with a cystic fibrosis related disorder includes administering a therapeutically effective amount of at least one PPAR? agonist or a derivative thereof.Type: ApplicationFiled: June 2, 2006Publication date: May 7, 2009Inventor: Pamela B. Davis
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Patent number: 7528133Abstract: The present invention provides methods of preventing or reducing oxytocin-mediated action by using a thiazolidinedione, such as troglitazone, or thiazolidinedione-like compounds. These methods describe the employment of these compounds alone or in combination with at least one other agent, such as a tocolytic agent. This offers a novel therapeutic regimen for the treatment of oxytocin-mediated actions, for example induction of uterine contractions, prostaglandin release, and milk letdown. Accordingly, conditions such as preterm labor and labor prior to Caesarian delivery can be treated by these methods.Type: GrantFiled: October 29, 1999Date of Patent: May 5, 2009Assignee: The Board of Regents of The University of Texas SystemInventors: John A. Copland, III, Kirk L. Ives, Melvyn Soloff
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Patent number: 7498327Abstract: The present invention provides a compound of formula I and the use thereof for the therapeutic treatment of disorders relating to or affected by the 5-HT6 receptor.Type: GrantFiled: June 22, 2005Date of Patent: March 3, 2009Assignee: WyethInventors: Youchu Wang, Chia-Cheng Shaw, Ronald Charles Bernotas, Chung-Chiee Paul Wang, Ping Cai, Zhi Wang
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Patent number: 7459473Abstract: This invention relates to novel N-linked sulfonamides of N-heterocyclic carboxylic acid and carboxylic acid isosteres, their preparation, and use for treating neurological disorders including physically damaged nerves and neurodegenerative diseases, and for treating alopecia and promoting hair growth.Type: GrantFiled: December 3, 1998Date of Patent: December 2, 2008Assignee: Glia Med, Inc.Inventors: Gregory S. Hamilton, Mark H. Norman, Yong-Qian Wu
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1-Heterocyclylalkyl-3-sulfonylazaindole or -azaindazole derivatives as 5-hydroxytryptamine-6 ligands
Patent number: 7411064Abstract: The present invention provides a compound of formula I and the use thereof for the treatment of a central nervous system disorder related to or affected by the 5-HT6 receptorType: GrantFiled: February 15, 2006Date of Patent: August 12, 2008Assignee: WyethInventors: Ronald Charles Bernotas, Steven Edward Lenicek, Hassan Mahmoud Elokdah, David Zenan Li -
Patent number: 7407987Abstract: A method for treating hair loss in mammals uses compositions containing prostaglandin F analogs. The compositions can be applied topically to the skin. The compositions can arrest hair loss, reverse hair loss, and promote hair growth.Type: GrantFiled: November 30, 2006Date of Patent: August 5, 2008Assignee: Duke UniversityInventors: Mitchell Anthony deLong, John McMillan McIver, Robert Scott Youngquist
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Publication number: 20080153886Abstract: The invention relates to the use of heterocyclic compounds in the preparation of a medicament for regenerating damaged neuronal tissue. According to a preferred embodiment, formula I compounds are used to produce a medicament for regenerating neuronal tissue in pathologies or conditions that involve neuronal damage or death in the central nervous system or peripheral nervous system.Type: ApplicationFiled: February 10, 2006Publication date: June 26, 2008Applicant: NEUROPHARMA, S.A.Inventors: Ana Martinez Gil, Rosario De Luna Medina, Ana Perez Castillo, Mercedes Alonso Cascon
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Patent number: 7388029Abstract: A method for treating hair loss in mammals uses compositions containing prostaglandin F analogs. The compositions can be applied topically to the skin. The compositions can arrest hair loss, reverse hair loss, and promote hair growth.Type: GrantFiled: May 26, 2005Date of Patent: June 17, 2008Assignee: Duke UniversityInventors: Mitchell Anthony DeLong, John McMillan McIver, Robert Scott Youngquist
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Patent number: 7361687Abstract: The present invention relates to novel arylsulphonamide compounds, defined by formula I and the description, as well as their method of preparation and their therapeutic useType: GrantFiled: June 12, 2003Date of Patent: April 22, 2008Assignee: Laboratoires Fournier SAInventors: Martine Barth, Michel Bondoux, Pierre Dodey, Christine Massardier, Jean-Michel Luccarini
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Patent number: 7348017Abstract: A dithiazole compound or a salt thereof is disclosed. The compound inhibits matrix metalloprotease (MMPs) activity and can be used in pharmaceutical and cosmetic compositions for the treatment of skin conditions.Type: GrantFiled: August 28, 2002Date of Patent: March 25, 2008Assignee: Shiseido Co., Ltd.Inventors: Takuya Hiruma, Koji Kobayashi, Shinji Inomata
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Patent number: 7329761Abstract: Novel imides are inhibitors of tumor necrosis factor alpha and can be used to combat cachexia, endotoxic shock, and retrovirus replication.Type: GrantFiled: November 16, 2004Date of Patent: February 12, 2008Assignee: Celgene CorporationInventors: George W. Muller, Mary Shire, David I. Stirling
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Patent number: 7259179Abstract: A compound of the general formula: or pharmaceutically acceptable salts, hydrates, solvates, crystal forms or diastereomers thereof is described. A method of treating protein kinase-associated disease states using the compound of formula I is also described.Type: GrantFiled: May 23, 2003Date of Patent: August 21, 2007Assignee: Cytopia Research Pty LtdInventors: Christopher John Burns, Xianyong Bu, Andrew Frederick Wilks
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Patent number: 7223780Abstract: The present invention is directed to the compound of formula I which is useful for inhibiting the activity of blood clotting enzyme Factor Xa. The present invention is also directed to compositions containing said compounds, processes for their preparation, their use, such as for inhibiting the formation of thrombin or for therapeutically treating a patient suffering from, or subject to, a disease state associated with a cardiovascular disorder.Type: GrantFiled: May 19, 2004Date of Patent: May 29, 2007Assignee: Sanofi-Aventis Deutschland GmbHInventors: Marc Nazare, Volker Laux, Armin Bauer, Michael Wagner
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Patent number: 7214701Abstract: The invention relates to insecticidal mixtures for protecting plants against attack by pests comprising (a) compounds of the formula (I) ?in which W, X, Y, Z, A, B, D and G are each as defined in the disclosure, and (b) specified agonists or antagonists of nicotinic acetylcholine receptors.Type: GrantFiled: June 25, 2004Date of Patent: May 8, 2007Assignee: Bayer CropScience AGInventors: Reiner Fischer, Christoph Erdelen
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Patent number: 7192940Abstract: The present invention relates to novel ether compounds, compositions comprising ether compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising an ether compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.Type: GrantFiled: July 16, 2004Date of Patent: March 20, 2007Assignee: Esperion Therapeutics, Inc.Inventors: Jean-Louis Henri Dasseux, Carmen Daniela Oniciu
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Patent number: 7129257Abstract: Pyrazolo[3,4-e]benzoxazoles and analogues thereof for lowering intraocular pressure and treating glaucoma are disclosed.Type: GrantFiled: December 15, 2004Date of Patent: October 31, 2006Assignee: Alcon, Inc.Inventors: Anura P. Dantanarayana, Jesse A. May
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Patent number: 7129256Abstract: A compound represented by the formula: wherein A is thiazolyl or the like, X is a bond or the like, m is an integer of 0 to 4, Y is optionally substituted alkyl or the like, Z is a substituent represented by the formula: wherein R3 is hydrogen atom or the like, R4 and R5 are each independently hydrogen atom or the like, W is —(CH2)n— (n is 0, 1, 2 or 3) or the like, a prodrug thereof, its pharmaceutically acceptable salt, or its solvate is useful as a composition for prevention or treatment of Parkinson's disease.Type: GrantFiled: August 29, 2001Date of Patent: October 31, 2006Assignee: Shionogi & Co., Ltd.Inventors: Shunji Shinohaea, Katsumi Koike
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Patent number: 7105556Abstract: Compounds are provided which have the structure wherein Q is C or N, X1 is C or N, and R1, R2, R2a, R2b, R2c, R3, Y, A, m, n, X2, X3 and X4 are as defined herein, which compounds are useful as antidiabetic, hypolipidemic, and antiobesity agents.Type: GrantFiled: May 22, 2002Date of Patent: September 12, 2006Assignee: Bristol-Myers Squibb CompanyInventors: Peter T. Cheng, Yoon Jeon, Wei Wang