1,3-thiazoles (including Hydrogenated) Patents (Class 514/365)
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Patent number: 11613534Abstract: Disclosed herein are compounds effective for activation of Tie-2 and inhibition of HPTP-beta. The compounds can provide effective therapy for vascular disorders that can include, for example, retinopathies, ocular edema, and ocular neovascularization.Type: GrantFiled: October 28, 2020Date of Patent: March 28, 2023Assignee: EyePoint Pharmaceuticals, Inc.Inventor: John M. Janusz
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Patent number: 11607403Abstract: The therapeutic uses of febuxostat or febuxostat derivatives and compositions comprising febuxostat or febuxostat derivatives to promote neurogenesis for the treatment of disease.Type: GrantFiled: November 8, 2016Date of Patent: March 21, 2023Assignee: Morningside Ventures LimitedInventors: Nancy Yuk-Yu Ip, Wing-Yu Fu, Fanny Chui Fun Ip, Kit Yu Fu
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Patent number: 11547698Abstract: The disclosure discloses an aryl hydrocarbon receptor modulators of formula (I), and pharmaceutically acceptable salts, R? is H, CN, CH2(OH)R0, CmH2m+1, CnH2n-1, CnH2n-3, two Ra is independently H, or two Ra together form ?O or ?N—W3—R1; A is a C6 to C10 aromatic ring, or a C2 to C10 heteroaromatic ring containing 1 to 5 heteroatom from N, O and S, or 4 to 7 membered non-aromatic heterocyclic ring containing 1 to 3 heteroatom from N, O and S and C?N, which are with no substituent or substituted by 1 or 3 R; Q is R, or a C6 to C10 aromatic ring or a C2 to C10 heteroaromatic ring containing 1 to 5 heteroatom selected from N, O and S, which are with no substituent or substituted by 1 or 3 R; R is Rc connected with C or RN connected with N.Type: GrantFiled: December 22, 2017Date of Patent: January 10, 2023Assignee: ARIAGEN, INC.Inventors: Luqing Yang, Guodong Li, Suoming Zhang
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Patent number: 11524004Abstract: Peroxisome proliferator activated receptor (PPAR) compounds, and methods of using the same for treating bone fractures, treating osteoporosis and/or metabolic bone diseases, and inducing osteogenesis and/or chondrogenesis, are disclosed.Type: GrantFiled: September 14, 2020Date of Patent: December 13, 2022Assignee: The University of ToledoInventors: Bruce E. Heck, Dong Hyun Kim, Paul W. Erhardt, Brian J. Kress
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Patent number: 11459322Abstract: The present disclosure relates to indole compounds and pharmaceutical compositions thereof, and their use in stimulating the immune system of patients in need thereof and in treating cancer.Type: GrantFiled: November 19, 2018Date of Patent: October 4, 2022Assignee: ARIAGEN, INC.Inventors: Peter Colabuono, Graham Johnson, David Douglas Manning, Mark Allan Wolf
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Patent number: 11427576Abstract: The present disclosure relates to indole compounds and pharmaceutical compositions thereof, and their use in stimulating the immune system of patients in need thereof and in treating cancer.Type: GrantFiled: February 18, 2021Date of Patent: August 30, 2022Assignee: ARIAGEN, INC.Inventors: Peter Colabuono, Graham Johnson, David Douglas Manning, Mark Allan Wolf
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Patent number: 11390621Abstract: The present disclosure relates to indole compounds and pharmaceutical compositions thereof, and their use in stimulating the immune system of patients in need thereof and in treating cancer.Type: GrantFiled: February 18, 2021Date of Patent: July 19, 2022Assignee: ARIAGEN, INC.Inventors: Graham Johnson, Peter Colabuono, Paul Gerard Pearson, David Douglas Manning
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Patent number: 11370787Abstract: Disclosed herein are embodiments of a pyrazole compound according to formula I. Compositions comprising the compound, and a method for making the composition also are disclosed. The composition may comprise a carrier, such as a polymer and/or the composition may be a spray-dried formulation. Also disclosed is a method for using the compound and/or composition. The compound and/or composition may be useful to inhibit an IRAK protein and/or to ameliorate, treat and/or prevent an IRAK-associated disease or condition in a subject.Type: GrantFiled: August 28, 2020Date of Patent: June 28, 2022Assignee: Rigel Pharmaceuticals, Inc.Inventors: Lu Chou, Matt Duan, Ihab Darwish, Simon Shaw, Somasekhar Bhamidipati, Vanessa Taylor, Yan Chen, Dazhong Fan, Zhushou Luo
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Patent number: 11266646Abstract: The present application relates to the use of bicyclic-substituted uracil derivatives, alone or in combinations with other active ingredients for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of inflammatory and fibrotic disorders, for the treatment of endometriosis, of endometriosis-associated fibrosis, of adenomyosis and of pain associated with an endometriosis disorder and also of postoperative peritoneal fibrosis and adhesion formation.Type: GrantFiled: December 13, 2017Date of Patent: March 8, 2022Assignee: Bayer Pharma AktiengesellschaftInventors: Michaele Peters, Markus Koch, Thomas Zollner
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Patent number: 11261179Abstract: Compounds having the general structure A-L-B are presented wherein A and B are independently an E3 ubiquitin ligase protein binding ligand compound of formula 1A or 1B. Pharmaceutical compositions comprising these compounds and methods of use are also presented.Type: GrantFiled: April 13, 2018Date of Patent: March 1, 2022Assignee: University of DundeeInventors: Alessio Ciulli, Chiara Maniaci, Scott J. Hughes, Andrea Testa
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Patent number: 11236058Abstract: The inventive subject matter provides compounds, compositions and methods for lowering serum acid (sUA) for the treatment of gout, and having reduced liver toxicity, associated with CYP2C9 metabolic pathway.Type: GrantFiled: November 14, 2019Date of Patent: February 1, 2022Assignee: ARTHROSI THERAPEUTICS, INC.Inventors: Shunqi Yan, Li-Tain Yeh, Robert Orr
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Patent number: 11191755Abstract: The invention provides compositions and methods for providing a cardioprotective effect in a subject. Specifically, the invention provides compositions and methods for treating cardiovascular ailments, for example, ischemia/reperfusion (I/R) injury, cardiac arrhythmias, oxidative stress, or cardiac failure by administering a retinoic acid receptor-beta (RAR?) agonist.Type: GrantFiled: June 14, 2018Date of Patent: December 7, 2021Assignee: Cornell UniversityInventors: Lorraine J Gudas, Xiao-Han Tang
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Patent number: 11186555Abstract: The present disclosure provides pharmaceutical compositions comprising Gamma-glutamyl cycle inhibitors (GGCI) and certain pharmaceutically acceptable salts thereof, and methods of use.Type: GrantFiled: June 17, 2019Date of Patent: November 30, 2021Assignee: CANCER RESEARCH TECHNOLOGY, LLCInventors: David Rubin, Eyal Rubin
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Patent number: 11161839Abstract: The present invention relates to compounds of formula I that function as inhibitors of BCL6 (B-cell lymphoma 6) activity: Formula I wherein X1, X2, X3, R1, R2, R3, R4 and R5 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which BCL6 activity is implicated.Type: GrantFiled: May 25, 2018Date of Patent: November 2, 2021Assignees: The Institute of Cancer Research: Royal Cancer Hospital, Cancer Research Technology LimitedInventors: Benjamin Richard Bellenie, Kwai Ming Jack Cheung, Owen Alexander Davis, Swen Hoelder, Rosemary Huckvale, Matthew Garth Lloyd
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Patent number: 11160769Abstract: This invention relates to pharmaceutical compositions and methods for treating (including managing) or preventing metabolic syndrome related conditions using one or more RAR e.g., RAR agonists. Such conditions include, but are not limited to, diseases in pancreas, liver, kidney, testes, muscle, or adipose tissue, as well as other organs that are associated with high fat diet and/or vitamin A deficiency, as well as other conditions associated with abnormal level of triglyceride, cholesterol and/or glucose.Type: GrantFiled: January 16, 2015Date of Patent: November 2, 2021Assignee: Cornell UniversityInventors: Lorraine J Gudas, Yannick Benoit, Ronald Perez, Xiao-Han Tang, Steven Trasino
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Patent number: 11040963Abstract: The present invention provides piperazine derivatives exhibiting high affinity to the stem region (viral membrane proximal part) of influenza hemagglutinin as determined through competition binding and high virus neutralization activity while having low cytotoxity. Furthermore, the present invention relates to pharmaceutical compositions comprising said piperazine derivatives, methods of preparing said piperazine derivatives, as well as said piperazine derivatives for use in medical prevention or treatment, especially for preventing or treating influenza.Type: GrantFiled: February 1, 2018Date of Patent: June 22, 2021Assignee: JANSSEN VACCINES & PREVENTION B.V.Inventors: Maria Van Dongen, Jaroslaw Juraszek, Griet Wim Bert Schepens, Charles Edward Lawson, Brian Shook, Maria Tim Hugo Jonckers, Abdellah Tahri, Bernard Pierre Jean-Marie Raboisson, Nestor CHristophe Francis Robert Buyck
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Patent number: 11033601Abstract: Disclosed herein are methods and compositions for treating nonalcoholic fatty liver disease. Specifically exemplified herein is administration of compositions comprising a V1b inhibitor or V1a agonist or V1a stabilizer.Type: GrantFiled: September 14, 2018Date of Patent: June 15, 2021Assignee: The Regents of the University of Colorado, a body corporateInventors: Richard J. Johnson, Miguel A. Lanaspa Garcia, Thomas Jensen
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Patent number: 10981897Abstract: The present invention provides compounds of the formula: (I) wherein: X is O or S; Q1 and Q2 are independently CR5 or N, provided at least one of Q1 and Q2 is N; Y is a direct bond or CH2; R1 is H, optionally substituted alkyl, alkenyl, alkynyl, cycloalkylalkyl, benzyl or oxetan-3-yl-CH2—; R2 is optionally substituted phenyl, pyridine, pyrimidine, pyrazine or pyridazine; R3 is alkyl or haloalkyl; R4 is optionally substituted pyridine, pyrimidine, pyrazine or pyridazine; R5 is H, alkyl, haloalkyl, cycloalkyl, alkoxy, alkoxyC(O)— or (alkoxy)2CH—; or a salt thereof. The compounds are useful for controlling ectoparasites on animals.Type: GrantFiled: April 30, 2019Date of Patent: April 20, 2021Assignee: Elanco Tiergesundheit AGInventors: Paolo Tosatti, Jean-Yves Wach
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Synergistic pharmaceutical combination for the treatment of squamous cell carcinoma of head and neck
Patent number: 10980776Abstract: The present invention relates to a pharmaceutical combination for use in the treatment of squamous cell carcinoma, comprising a CDK inhibitor selected from the compounds of formula (I); or a pharmaceutically acceptable salt thereof and one or more antineoplastic agents selected from sorafenib, lapatinib, erlotinib, cisplatin, 5-fluorouracil, docetaxel or cetuximab or a pharmaceutically acceptable salt thereof. The said pharmaceutical combination exhibits synergy when used in the treatment of squamous cell carcinoma of head and neck (SCCHN). The invention also relates to a pharmaceutical composition comprising the said combination and a method for the treatment of squamous cell carcinoma of head and neck (SCCHN), using a therapeutically effective amount of said combination.Type: GrantFiled: February 8, 2019Date of Patent: April 20, 2021Assignee: PIRAMAL ENTERPRISES LIMITEDInventors: Veena Agarwal, Arun Balakrishnan, Giridharan Periyasamy -
Patent number: 10980782Abstract: The present application discloses a pharmaceutical preparation comprising a de-epoxidized epothilone derivative, and especially relates to a preparation formulation of a compound with reduced allergens and toxicity; and also relates to the use thereof in the treatment of tumours, especially the use thereof in the treatment of solid tumours that are resistant to and fail to respond to other conventional chemotherapeutic agents, as well as the use thereof in the treatment of cancers alone or in combination with other tumour drugs or auxiliary drugs.Type: GrantFiled: February 6, 2017Date of Patent: April 20, 2021Assignees: BEIJING BIOSTAR TECHNOLOGIES, LTD., CHENGDU BIOSTAR PHARMACEUTICALS, LTD.Inventors: Li Tang, Rongguo Qiu
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Patent number: 10968185Abstract: Inhibitor compounds and agents of Cathepsin C, CELA1, CELA3A and/or structurally related molecules thereto, compositions comprising same and uses thereof in the inhibition and/or prevention of cell and/or tissue necrosis are described. The compounds include thiazoles of Formula II, where G1 is an optionally substituted pyrrolidine, an optionally substituted pyridine, an optionally substituted aryl, an optionally substituted piperidine, an optionally substituted piperazine, an optionally substituted imidazolidine, or an optionally substituted pyrazolidine. G3 is or G3 is an optionally substituted alkyl, an optionally substituted aryl or an optionally cyloalkyl. G2 is an optionally substituted alkyl, an optionally substituted aryl, an optionally substituted cyloalkyl or an optionally substituted heterocycle. Various applications for the described compounds, and combination therapies are described as well.Type: GrantFiled: April 7, 2016Date of Patent: April 6, 2021Assignee: ELA PHARMA LTD.Inventors: Ilana Nathan, Boris Khalfin
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Patent number: 10954230Abstract: This invention relates to a method of preparing inhibitors of glucosylceramide synthase (GCS) useful for the treatment metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, and for the treatment of cancer.Type: GrantFiled: February 14, 2020Date of Patent: March 23, 2021Assignee: GENZYME CORPORATIONInventors: Craig S. Siegel, Rayomand Gimi, Michael Reardon, Jin Zhao
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Patent number: 10941125Abstract: Peroxisome proliferator activated receptor (PPAR) compounds, and methods of using the same for treating bone fractures, treating osteoporosis and/or metabolic bone diseases, and inducing osteogenesis and/or chondrogenesis, are disclosed.Type: GrantFiled: July 8, 2019Date of Patent: March 9, 2021Assignee: The University of ToledoInventors: Bruce E. Heck, Dong Hyun Kim, Paul W. Erhardt, Brian Kress
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Patent number: 10927138Abstract: Provided herein are compounds of Formula (I) and uses thereof for inhibiting the activity of D-amino acid oxidase (DAAO) or treating diseases or disorders associated with DAAO, such as a central nervous system (CNS) disorder, obesity, diabetes, or hyperlipidemia. Also provided in the present disclosure are methods of synthesizing the Formula (I) compounds described herein.Type: GrantFiled: May 29, 2018Date of Patent: February 23, 2021Assignee: SYNEURX INTERNATIONAL (TAIWAN) CORP.Inventors: Guochuan Emil Tsai, Ching-Cheng Wang, Ming-Hong Chien, Tien-Lan Hsieh
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Patent number: 10776461Abstract: Peroxisome proliferator activated receptor (PPAR) compounds, and methods of using the same for treating bone fractures, treating osteoporosis and/or metabolic bone diseases, and inducing osteogenesis and/or chondrogenesis, are disclosed.Type: GrantFiled: January 14, 2019Date of Patent: September 15, 2020Assignee: The University of ToledoInventors: Bruce E. Heck, Dong Hyun Kim, Paul W. Erhardt, Brian J. Kress
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Patent number: 10765629Abstract: Described herein is a solid complex comprising (Z)-7-((1R,2R,3R,5S)-2-((S,E)-5-(2,5-dichlorothiophen-3-yl)-3-hydroxypent-1-en-1-yl)-3,5-dihydroxycyclopentyl)hept-5-enamide (hereinafter “Compound 1”) and ?-cyclodextrin, and preparations and uses thereof. Also described herein are certain solid forms, preparations and uses thereof.Type: GrantFiled: July 24, 2018Date of Patent: September 8, 2020Assignee: ALLERGAN, INC.Inventors: Ke Wu, Evgenyi Shalaev, Prem Swaroop Mohanty, Jinping Wan
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Patent number: 10723727Abstract: The present invention is directed to novel cytotoxic tubulysin analogs and derivatives, to antibody drug conjugates thereof, and to methods for using the same to treat medical conditions including cancer.Type: GrantFiled: January 27, 2017Date of Patent: July 28, 2020Assignee: Pfizer Inc.Inventors: Chakrapani Subramanyam, Lawrence N. Tumey, Longfei Xie, Carolyn Leverett, Beth C. Vetelino, Sai Chetan K. Sukuru, Sarah Hudson, Venkata Ramana Doppalapudi, Abhijit S. Bhat
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Patent number: 10675273Abstract: Disclosed herein, inter alia, are compounds and methods for increasing spine density in a neuron, and for treatment of neuronal diseases and cancer.Type: GrantFiled: January 4, 2017Date of Patent: June 9, 2020Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventor: Jerry Yang
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Patent number: 10669588Abstract: This invention relates to a novel approach for the identification and stratification of subtypes of cancer, particularly pancreatic ductal adenocarcinoma (PDAC). The invention furthermore relates to a novel approach with respect to the treatment of cancer, particularly pancreatic ductal adenocarcinoma (PDAC).Type: GrantFiled: September 28, 2015Date of Patent: June 2, 2020Assignee: HI-STEM GGMBHInventors: Andreas Trumpp, Martin Ronald Sprick, Elisa Noll
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Patent number: 10632106Abstract: Provided herein are methods of cancer treatment by administering an effective amount of an endogenous ligand for the aryl hydrocarbon (Ah) receptor (AhR) named ITE or one of its structural analogs to a patient with cancer, for example, prostate, liver, lung, ovarian, breast, skin, colon (or rectum), stomach, pancreatic, kidney, bladder, soft tissue, or cervical cancer.Type: GrantFiled: July 27, 2018Date of Patent: April 28, 2020Assignee: Ariagen, Inc.Inventor: Jiasheng Song
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Patent number: 10617674Abstract: This invention relates to a novel dosage regimen for administration of 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol-1-yl]-N-cyclopropyl-4-methylbenzamide or a pharmaceutically acceptable derivative thereof, namely in the treatment of acute exacerbations of inflammatory conditions.Type: GrantFiled: March 8, 2016Date of Patent: April 14, 2020Assignee: MEREO BIOPHARMA 1 LIMITEDInventors: Colin Orford, Cyril Clarke, Colm Farrell, Jacqueline Parkin, Stefan De Buck
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Patent number: 10464942Abstract: The invention relates to the process of manufacturing Epothilone compounds of Formulas I-IV. The process of the present invention is totally synthetic, utilizes highly pure and crystalline Epothilone B, and produces ixabepilone in high efficiency, purity, and yield.Type: GrantFiled: November 20, 2017Date of Patent: November 5, 2019Assignee: PHARMAREN, LLCInventors: Jalal Haddad, Sourena Nadji
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Patent number: 10450292Abstract: The invention provides compounds that are inhibitors of bacterial RNA polymerase. The invention also provides compositions comprising such compounds, methods of making such compounds, and methods of using said compounds. The invention has applications in control of bacterial gene expression, control of bacterial growth, antibacterial chemistry, and antibacterial therapy.Type: GrantFiled: December 9, 2016Date of Patent: October 22, 2019Assignee: Rutgers, The State University of New JersesyInventors: Richard H. Ebright, Joel Freundlich, Nisha Mittal, Mark Jaskowski, Juan Shen
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Patent number: 10322110Abstract: The present invention relates to therapeutic agents suitable for use in the treatment of microbial infection in mammals. The present invention further relates to the use of pharmaceutical compositions comprising said agents in the treatment of medical conditions in mammals, in particular in the treatment of microbial infection. The agents and pharmaceutical compositions of the invention are of particular relevance in the treatment of diseases associated with antibiotic-resistant microbes. In one particular embodiment, the pharmaceutical composition can have the structural moiety of formula (I) or a pharmaceutically-acceptable salt of said compound: wherein group A is selected from the formulae Group B is aryl, R1 is an optionally substituted aryl ring, an optionally substituted benzyl ring, CH3, or C2 to 6 alkyl, and R2 is hydrogen, an alkyl group, a halogen, or —(CH2)nN(CH3)2 where n is an integer from 1 to 3.Type: GrantFiled: December 3, 2015Date of Patent: June 18, 2019Assignee: Procomcure Biotech GmbHInventors: Kamil Önder, Roelf Datema, Dale Mitchell, Ivan Kondratov
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Patent number: 10315998Abstract: The present invention belongs to the field of fungicides, and relates to an amide compound and the preparation method and use thereof. The amide compound is as shown in general formula I: Each substituent in Formula I is defined in the description. The compound of general formula I of the present invention has an outstanding fungicidal activity, and can be used for controlling fungal diseases.Type: GrantFiled: May 4, 2016Date of Patent: June 11, 2019Assignee: SHENYANG SINOCHEM AGROCHEMICALS R&D CO., LTD.Inventors: Liang Lv, Gang Wang, Zhonggang Shan, Jiyong Liu, Qin Sun, Junfeng Wang, Bin Li
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Patent number: 10272055Abstract: Biguanide compounds and salts thereof are disclosed. Also disclosed are pharmaceutical compositions and therapeutic methods for treating certain diseases including cancer such as breast cancer.Type: GrantFiled: March 6, 2015Date of Patent: April 30, 2019Assignees: Regents of the University of Minnesota, The Regents of the University of CaliforniaInventors: David A. Potter, Zhijun Guo, Elizabeth Amin, Gunda Georg, Tom Poulos, Irina Sevrioukova
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Synergistic pharmaceutical combination for the treatment of squamous cell carcinoma of head and neck
Patent number: 10245251Abstract: The present invention relates to a pharmaceutical combination for use in the treatment of squamous cell carcinoma, comprising a CDK inhibitor selected from the compounds of formula (I); or a pharmaceutically acceptable salt thereof and one or more antineoplastic agents selected from sorafenib, lapatinib, erlotinib, cisplatin, 5-fluorouracil, docetaxel or cetuximab or a pharmaceutically acceptable salt thereof. The said pharmaceutical combination exhibits synergy when used in the treatment of squamous cell carcinoma of head and neck (SCCHN). The invention also relates to a pharmaceutical composition comprising the said combination and a method for the treatment of squamous cell carcinoma of head and neck (SCCHN), using a therapeutically effective amount of said combination.Type: GrantFiled: July 8, 2016Date of Patent: April 2, 2019Assignee: PIRAMAL ENTERPRISES LIMITEDInventors: Veena Agarwal, Arun Balakrishnan, Giridharan Periyasamy -
Patent number: 10221169Abstract: Disclosed ore substituted aminothiazoles, which can be used for, among other things, the treatment of tuberculosis, pharmaceutical compositions containing the same, and methods of using the same.Type: GrantFiled: March 23, 2017Date of Patent: March 5, 2019Assignees: The Broad Institute, Inc., The General Hospital Corporation, The Brigham and Women's Hospital, Inc.Inventors: Deborah Hung, Michael Serrano-Wu, Sarah Grant, Tomohiko Kawate
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Patent number: 10195182Abstract: A method of cancer intervention or eradication by administering an effective amount of an endogenous ligand for the aryl hydrocarbon (Ah) receptor (AhR) named ITE or one of its analogs (the active ingredient) to a subject with cancer is disclosed. An effective dose and dosing frequency of the active ingredient are determined by measuring its blood levels of the subject after dosing. The active ingredient formulated with a carrier system is applied topically, enterally, or parenterally to the subject. The formulated drug can also be administered together with one or more of other cancer therapeutic agents. A maintenance dosing is provided after the subject is free of cancer to insure the cancer eradication. Subjects with cancers of prostate, liver, lung, ovarian, and breast are preferably accepted for treatment.Type: GrantFiled: June 5, 2017Date of Patent: February 5, 2019Assignee: Ariagen, Inc.Inventor: Jiasheng Song
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Patent number: 10188639Abstract: The invention provides enantiopure deuterium-enriched pioglitazone, pharmaceutical compositions, and methods of treating neurological disorders, cancer, respiratory disorders, metabolic disorders, and other disorders using enantiopure deuterium-enriched pioglitazone. A preferred aspect of the invention provides methods of treating Alzheimer's disease, non-small cell lung cancer, hepatocellular carcinoma, and chronic obstructive pulmonary disease using enantiopure deuterium-enriched pioglitazone.Type: GrantFiled: January 15, 2015Date of Patent: January 29, 2019Assignee: DeuteRx, LLCInventors: Sheila DeWitt, Vincent Jacques, Leonardus H. T. van der Ploeg
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Patent number: 10179780Abstract: There are provided: 4-methyl-2-[4-(2-methylpropoxy)-3-(1H-1,2,3,4-tetrazol-1-yl)phenyl]-1,3-thiazole-5-carboxylic acid, a sodium salt thereof and crystals of these, useful as a therapeutic agent and a prophylactic agent for gout, hyperuricemia and the like, and a method for producing the same.Type: GrantFiled: July 29, 2015Date of Patent: January 15, 2019Assignee: Teijin Pharma LimitedInventors: Asahi Kawana, Hisae Nozato, Chikashi Kanazawa
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Patent number: 10138216Abstract: Described herein are analogues of 2-methyl-3-(2-ethynylthiazol-4-yl)cyclopent-2-enol and the corresponding ketone 3-(2-ethynylthiazol-4-yl)-2-methylcyclopent-2-enone, the analogues having terminal alkyne groups at the 2-position of the thiazole ring. These drug-like molecules, referred to as CETZOLE compounds, are useful to treat non-small cell lung cancer and other forms of cancer. Methods of making and using the compounds, methods of treating various diseases, pharmaceutical compositions, and kits are also disclosed.Type: GrantFiled: September 18, 2017Date of Patent: November 27, 2018Assignee: The University of ToledoInventors: Viranga Tillekeratne, William Taylor, Sara Fedorka
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Patent number: 10117877Abstract: Disclosed herein are methods, compounds, and compositions for fat reduction, and in particular fat reduction without significant hair growth and/or additional hair growth.Type: GrantFiled: September 29, 2017Date of Patent: November 6, 2018Assignee: ALLERGAN, INC.Inventors: Neil J. Poloso, Jenny Wang, David F. Woodward, Robert M. Burk
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Patent number: 10092617Abstract: The present invention relates to the field of nanotechnology, in particular, to the production of biodegradable polymeric nanoparticles. The present invention provides a biodegradable polymeric nanoparticle made up of a block copolymer and a process for producing the same. The nanoparticles are produced without the use of any emulsifiers and have a size ranging from 30-120 nm. The methods of controlling the drug loading capacity are disclosed along with the process of producing entity-loaded nanoparticles. Compositions comprising the nanoparticles and their use in therapeutics, diagnostics and theranostics are also disclosed.Type: GrantFiled: April 22, 2013Date of Patent: October 9, 2018Assignee: NANOPROTEAGENInventor: Harpal Singh
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Patent number: 10073072Abstract: This disclosure describes the results of the studies conducted to develop a dissolution method to monitor release profiles of hydrophobic active pharmaceutical ingredients such as ivermectin with or without pyrantel pamoate from a drug product made of complex matrix that includes, but is not limited to beef, tallow, corn cob and soy protein.Type: GrantFiled: October 1, 2015Date of Patent: September 11, 2018Assignee: MERIAL INC.Inventors: Abu M. Rustum, Satish Kumar, Andrew L. McAdoo
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Patent number: 10065950Abstract: [Problem] Provided is a novel 1,3,4,8-tetrahydro-2H-pyrido[1,2-a]pyrazine derivative or a pharmaceutically acceptable salt thereof, or a solvate thereof, which is useful as an anti-HIV agent. [Solving Means] The present invention provides a compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof, or a solvate thereof.Type: GrantFiled: February 25, 2011Date of Patent: September 4, 2018Assignee: Japan Tobacco Inc.Inventors: Susumu Miyazaki, Yuki Bessho, Kaoru Adachi, Seiji Kawashita, Hirotaka Isoshima, Kengo Oshita, Shunichi Fukuda
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Patent number: 10043292Abstract: A computer-controlled system determines attributes of a frexel, which is an area of human skin, and applies a reflectance modifying agent (RMA) at the pixel level to automatically change the appearance of human features based on one or more digital images. The change may be based on a digital image of the same frexel, for as seen in a prior digital photograph captured previously by the computer-controlled system. The system scans the frexel and uses feature recognition software to compare the person's current features in the frexel with that person's features in the digital image. It then calculates enhancements to the make the current features appear more like the features in the digital image, and it applies the RMA to the frexel to accomplish the enhancements. Or the change may be based on a digital image of another person, through the application of RMAs.Type: GrantFiled: September 19, 2016Date of Patent: August 7, 2018Assignee: TCMS Transparent Beauty LLCInventors: Albert D. Edgar, David C. Iglehart, Rick B. Yeager
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Patent number: 10028508Abstract: The invention is in the technical field of vector control as well as insecticide-resistant mosquito and bed bug control. The active compound compositions of this invention are used against mosquitos and bed bugs which transmit disease pathogens or which annoy the well-being of humans and animals. The active compound compositions of this invention are in particular useful to overcome target-specific and/or metabolic-specific resistance of mosquitos and bed bugs and are biologically efficient on a variety of surfaces over an extended period of time.Type: GrantFiled: June 19, 2015Date of Patent: July 24, 2018Assignee: BAYER CROPSCIENCE AKTIENGESELLSCHAFTInventors: Karin Horn, Rainer Sonneck, Arnoldus Vermeer, Sebastian Horstmann, Guenther Nentwig, Frederic Schmitt
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Patent number: 10010535Abstract: Iron overload is associated with pathological conditions such as oxidative stress, transfusional iron overload, thalassemia, primary hemochromatosis, secondary hemochromatosis, diabetes, liver disease, heart disease, cancer, radiation injury, neurological or neurodegenerative disorder, Friedreich's ataxia (FRDA), macular degeneration, closed head injury, irritable bowel disease, and reperfusion injury. The present invention provides methods and pharmaceutical compositions using desferrithiocin analogs of Formulae (A) and (J) for treating and/or preventing these pathological conditions, metal (e.g., iron, aluminum, a lanthanide, or an actinide (e.g., uranium)) overload conditions, and infectious diseases (e.g., malaria).Type: GrantFiled: November 21, 2014Date of Patent: July 3, 2018Assignee: University of Florida Research Foundation, IncorporatedInventor: Raymond J. Bergeron, Jr.
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Patent number: 10000474Abstract: Provided herein are compounds of the formula (I) as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of cancer. Additionally, provided is a method for treating cancer, comprising the step of administering a therapeutically effective amount of a compound according to formula (I), or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier to a patient in need thereof.Type: GrantFiled: November 6, 2015Date of Patent: June 19, 2018Assignee: MUSC FOUNDATION FOR RESEARCH DEVELOPMENTInventors: Patrick M. Woster, Youxuan Li