Polycyclo Ring System Having The Thiazole Ring As One Of The Cyclos Patents (Class 514/373)
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Publication number: 20100233166Abstract: Compounds, compositions and methods for the treatment of malignancy are disclosed.Type: ApplicationFiled: April 13, 2010Publication date: September 16, 2010Inventors: George C. Prendergast, Alexander J. Muller, James B. Duhadaway, William Malachowski
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Publication number: 20100227804Abstract: It is an object of the present invention to provide a gel-forming composition which permits on-site administration and can form a gel exhibiting prescribed strength and sustained drug release, devices for the administration thereof, and a kit for medical use. A gel-forming composition which is composed of the first composition comprising a drug, a first gelling agent represented by the general formula (I) and the like, and the first diluent and the second composition comprising the second gelling agent represented by the general formula (I) and the like and the second diluent; and application devices and kits for medical use, which can hold the gel-forming composition. X1—(OCH2CH2)n—X2 (I) wherein X1 and X2 are each —R1COONHS (wherein R1 is C1-7 alkylene), —COR1COONHS, —NOCOR1—R2 (wherein R2 is maleimido), —R1NH2, —R1SH, or —CO2PhNO2, and n is an integer of 80 to 1000.Type: ApplicationFiled: January 17, 2007Publication date: September 9, 2010Applicants: THE UNIVERSITY OF TOKYO, NEXT21 K.K.Inventors: Nobuo Sasaki, Yuichi Tei, Shigeki Suzuki, Toru Hakukawa
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Patent number: 7790722Abstract: The present invention relates generally to the field of ligands for nicotinic acetylcholine receptors (nAChR), activation of nAChRs, and the treatment of disease conditions associated with defective or malfunctioning nicotinic acetylcholine receptors, especially of the brain. Further, this invention relates to novel compounds for example, indoles, 1H-indazoles, 1,2-benzisoxazoles, and 1,2-benzisothiazoles, which act as ligands for the ?7 nAChR subtype, methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.Type: GrantFiled: May 29, 2008Date of Patent: September 7, 2010Assignee: Memory Pharmaceuticals CorporationInventors: Wenge Xie, Brian Herbert, Jianguo Ma, Truc Minh Nguyen, Richard Schumacher, Carla Maria Gauss, Ashok Tehim
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Publication number: 20100215777Abstract: Compounds of formula (I) wherein the symbols have the meaning given in the specification, as well as processes for preparing the compounds (I), pesticidal compositions and synergistic mixtures comprising compounds (I), methods for the control of insects, acarids or nematodes by contacting the pests or their food supply, habitat or breeding grounds with a pesticidally effective amount of compounds formula (I), and a method for treating, controlling, preventing or protecting animals against infestation or infection by parasites which comprises orally, topically or parenterally administering or applying to the animals a parasiticidally effective amount of compounds of formula (I).Type: ApplicationFiled: June 22, 2007Publication date: August 26, 2010Applicant: BASF SEInventors: Matthias Pohlman, Michael Hofmann, Henricus Maria Martinus Bastiaans, Michael Rack, Deborah L. Culbertson, Hassan Oloumi-Sadeghi, Takeo Hokama, Christopher Palmer
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Patent number: 7781436Abstract: The present invention relates to indol-3-yl-carbonyl-piperidin and piperazin derivatives which act as V1a receptor antagonists and which are represented by Formula I: wherein the residues R1 to R3 are as defined herein. The invention also relates to pharmaceutical compositions containing such compounds, and methods for preparation of the compounds and compositions. The invention further relates to methods for treating dysmenorrhea, hypertension, chronic heart failure, inappropriate secretion of vasopressin, liver cirrhosis, nephrotic syndrome, obsessive compulsive disorder, anxiety and depressive disorders.Type: GrantFiled: July 25, 2006Date of Patent: August 24, 2010Assignee: Hoffmann-La Roche Inc.Inventors: Caterina Bissantz, Christophe Grundschober, Hasane Ratni, Mark Rogers-Evans, Patrick Schnider
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Patent number: 7781466Abstract: The invention relates to a preservative comprising at least one isothiazolone, at least one quaternary ammonium compound, and at least one stabilizer selected from the group of sulphite salts, hydrogen sulphite salts, sulphite-releasing compounds and hydrogen-sulphite-releasing compounds, the presence of algicidal triazine being ruled out. The preservative inhibits the growth of fungi, algae and bacteria on or in alkaline coating compositions. The invention furthermore relates to a process for the preparation of the preservative, to its use in a coating composition, and to the preserved composition.Type: GrantFiled: September 21, 2006Date of Patent: August 24, 2010Assignee: Air Liquide Sante (International)Inventors: Petra Kolditz, Klaus Weber, Ralf Gradtke, Wolfgang Beilfuss
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Patent number: 7772263Abstract: This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF-? or combinations thereof.Type: GrantFiled: February 3, 2009Date of Patent: August 10, 2010Assignee: Schering CorporationInventors: Brian J. Lavey, Joseph A. Kozlowski, Guowei Zhou, Ling Tong, Wensheng Yu, Michael K. C. Wong, Bandarpalle B. Shankar, Neng-Yang Shih, M. Arshad Siddiqui, Kristin E. Rosner, Chaoyang Dai, Janeta Popovici-Muller, Vinay M. Girijavallabhan, Dansu Li, Razia Rizvi, Lei Chen, De-Yi Yang, Robert Feltz, Seong Heon Kim
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Publication number: 20100173959Abstract: A method of controlling or preventing pest damage in a plant propagation material, a plant, and/or plant organs that grow at a later point in time, which comprises applying on the plant propagation material or locus thereof a compound I or II represented by formula (I) and (II) wherein R1 is represented, for example, by H; R6 is represented, for example, by H; R2 is represented, for example, by halogen; R3 to R5 is represented, for example, by H; and n is either 0 or 2; or an enantiomer, diastereomer, or salt, thereof.Type: ApplicationFiled: May 15, 2008Publication date: July 8, 2010Applicant: SYNGENTA CROP PROTECTION, INC.Inventors: Peter Renold, Ottmar Franz Huetter, Peter Maienfisch, Werner Zambach, Thomas Pitterna, Christoph Grimm
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Publication number: 20100167922Abstract: The present invention relates to 3-amino-1,2-benzisothiazole compounds of formula I wherein R1, R2, R3, R4, R5 and n are defined in the description. The present invention relates to insecticidal compounds of formula I and to their isomeric imino derivatives, as well as to the enantiomers, diastereomers and salts thereof and to compositions comprising such compounds. The invention also relates to the use of the 3-amino-1,2-benzisothiazole compounds, of their salts or of compositions comprising them for combating animal pests. Furthermore the invention relates also to methods of applying such compounds.Type: ApplicationFiled: March 22, 2007Publication date: July 1, 2010Applicant: BASF SEInventors: Matthias Pohlman, Wolfgang von Deyn, Florian Kaiser, Ernst Baumann, Michael Rack, Douglas D. Anspaugh, Deborah L. Culbertson, Henry Van Tuyl Cotter
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Publication number: 20100168164Abstract: Phenoxyphenyl and phenoxybenzyl oxazolidine-2,4-diones and thiazolidine-2,4-diones are agonists or partial agonists of PPAR gamma and are useful in the treatment and control of hyperglycemia that is symptomatic of type II diabetes, as well as dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, and obesity that are often associated with type 2 diabetes.Type: ApplicationFiled: June 30, 2006Publication date: July 1, 2010Inventors: James F. Dropinski, Peter T. Meinke, Guo Q. Shi, Yong Zhang
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Publication number: 20100168121Abstract: Compositions and methods for treating disorders of the outer retina with compounds with 5-HT1A agonist activity are disclosed.Type: ApplicationFiled: March 8, 2010Publication date: July 1, 2010Applicant: ALCON, INC.Inventors: Robert J. Collier, JR., Michael A. Kapin, Mark R. Hellberg, Thomas R. Dean
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Publication number: 20100160396Abstract: The present invention comprises 2-cyanobenzenesulfonic acid amides of the formula (I) and isomeric forms thereof (I-A) and (I-B) wherein R1, R2, R3, R4, R5 and A have the aforesaid meaning for the control of animal pests with the use of penetration enhancers and/or ammonium or phosphonium salts.Type: ApplicationFiled: May 21, 2008Publication date: June 24, 2010Applicant: Bayer ScropScience AGInventor: Reiner FISCHER
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Patent number: 7732434Abstract: There is provided a series of heterocyclic-containing macrocyclic acyl guanidines of Formula (I) or a stereoisomer; or a nontoxic pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, n and X as defined herein, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein (APP) by ?-secretase and, more specifically, inhibit the production of A?-peptide. The present disclosure is directed to compounds useful in the treatment of neurological disorders related to ?-amyloid production, such as Alzheimer's disease and other conditions affected by anti-amyloid activity.Type: GrantFiled: April 8, 2008Date of Patent: June 8, 2010Assignee: Bristol-Myers Squibb CompanyInventors: Shuhao Shi, Samuel Gerritz, Shirong Zhu
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Publication number: 20100137298Abstract: The present invention relates to biaryl sulfonamides and their use as, for example, metalloproteinase inhibitors.Type: ApplicationFiled: June 13, 2008Publication date: June 3, 2010Applicant: WyethInventors: Jeremy Ian Levin, Thomas Saltmarsh Rush, III, Frank Lovering, Yonghan Hu, Jianchang Li, Wei Li, Jun Jun Wu, Rajeev Hotchandani, Jason Shaoyun Xiang, Xuemei Du, Derek Cecil Cole, Steve Yikkai Tam
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Publication number: 20100130538Abstract: The present invention provides a compound represented by the formula wherein R1 is a hydrocarbon group optionally having substituent(s), amino optionally having substituent(s), hydroxy optionally having a substituent or a heterocyclic group optionally having substituent(s); R2 is a hydrogen atom or a hydrocarbon group optionally having substituent(s); Xa and Xb are each C, N, O or S; Xc and Xd are each C or N; m is 0-2; n is 1-3; ring A is a 5-membered ring optionally having substituent(s); ring B is a 6-membered ring optionally having substituent(s); and ring C is a 3- to 5-membered ring optionally having substituent(s), provided that when Xa, Xc and Xd are each C, then Xb is N or S, or a salt thereof, which is useful as an agent for the prophylaxis or treatment of a disease relating to an action of melatonin, and the like.Type: ApplicationFiled: April 25, 2008Publication date: May 27, 2010Inventors: Tatsuki Koike, Takafumi Takai, Yasutaka Hoashi
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Patent number: 7714140Abstract: A 1,2-benzoisothiazole derivative or a salt thereof is not harmful to a crop and is remarkably effective against agricultural or horticultural plant diseases such as Pyricularia oryzae, Septoria nodorum, Pseudoperonospora cubensis and Colletotrichum orbiculare, and an agricultural or horticultural plant disease-controlling agent containing the derivative or its salt as an active ingredient. The 1,2-benzoisothiazole derivative is represented by the general formula [I]: (wherein R1 is a hydrogen atom or a halogen atom, and R2 is a methyl group or a halogen atom), or a salt thereof.Type: GrantFiled: April 20, 2007Date of Patent: May 11, 2010Assignees: Kumiai Chemical Industry, Co. Ltd., Ihara Chemical Industry Co., Ltd.Inventors: Toshihiro Nagata, Atsushi Kogure, Isao Kaneko, Norihisa Yonekura, Ryo Hanai
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Patent number: 7714139Abstract: Compounds, compositions and methods for the treatment of malignancy are disclosed.Type: GrantFiled: February 20, 2004Date of Patent: May 11, 2010Assignee: Lankenau Institute for Medcial ResearchInventors: George C. Prendergast, Alexander J. Muller, James B. Duhadaway, William Malachowski
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Publication number: 20100093736Abstract: Biocidal compositions and their use in aqueous media, such as metalworking fluids, the compositions comprising a biocidal agent; and a non-biocidal primary amino alcohol compound of the formula (I); wherein R1, R2, R3, R4, and R5 are as defined herein.Type: ApplicationFiled: December 13, 2007Publication date: April 15, 2010Applicants: ANGUS CHEMICAL COMPANY, DOW GLOBAL TECHNOLOGIES INC.Inventors: Charles E. Coburn, John L. Pohlman, Bonnie A. Pyzowski, Patrick E. Brutto, George David Green, Raymond J. Swedo
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Patent number: 7687527Abstract: This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate, ester or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof.Type: GrantFiled: December 18, 2008Date of Patent: March 30, 2010Assignee: Schering CorporationInventors: Wensheng Yu, Ling Tong, Lei Chen, Joseph A. Kozlowski, Brian J. Lavey, Neng-Yang Shih, Vincent S. Madison, Guowei Zhou, Peter Orth, Zhuyan Guo, Michael K. C. Wong, De-Yi Yang, Seong Heon Kim, Bandarpalle B. Shankar, M. Arshad Siddiqui, Kristin E. Rosner, Chaoyang Dai, Umar Faruk Mansoor, Janeta Popovici-Muller, Vinay M. Girijavallabhan, Dansu Li
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Patent number: 7683085Abstract: This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, TNF- or combinations thereof.Type: GrantFiled: December 18, 2008Date of Patent: March 23, 2010Assignee: Schering CorporationInventors: Wensheng Yu, Ling Tong, Lei Chen, Joseph A. Kozlowski, Brian J. Lavey, Neng-Yang Shih, Vincent S. Madison, Guowei Zhou, Peter Orth, Zhuyan Guo, Michael K. C. Wong, De-Yi Yang, Seong Heon Kim, Bandarpalle B. Shankar
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Patent number: 7674810Abstract: Compounds having the formula i wherein m, R1, R2, R4 and X1 are herein defined are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for inhibiting hepatitis replication, processes for making the compounds and synthetic intermediates used in the process.Type: GrantFiled: April 28, 2006Date of Patent: March 9, 2010Assignee: Roche Palo Alto LLCInventors: James F. Blake, Jay Bradford Fell, John P. Fischer, Robert Than Hendricks, Stacey Renee Spencer, Peter J. Stengel
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Patent number: 7666887Abstract: What is described herein is a neutral pH, VOC-free biocidal composition of 1,2-benzisothiazolin-3-one which is stable at low temperatures for an extended period of time. The compositions are particularly advantageous in use in protecting latex, paint, coating, cosmetic and personal care formulations against microbiological spoilage.Type: GrantFiled: September 12, 2006Date of Patent: February 23, 2010Assignee: ISP Investments, Inc.Inventors: Xianbin Liu, Karen Winkowski
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Patent number: 7655681Abstract: A method of treating or preventing Obstructive Sleep Apnea (OSA) comprises the administration of a pharmacologically effective amount of zonisamide to a patient in need thereof, with the proviso that OSA caused by external mechanical obstruction of the airways, such as by mucus, is excluded. Also disclosed is the use of zonisamide for the manufacture of a medicament useful in the treatment; a protective patch comprising zonisamide and a pharmaceutically acceptable carrier for transdermal or transmucosal administration to a person suffering from OSA; and the use of zonisamide for the manufacture of a diagnostic device, kit or composition for the diagnosis of sleep disordered breathing.Type: GrantFiled: February 15, 2005Date of Patent: February 2, 2010Inventors: Ludger Grote, Kaj Stenlof, Jan Hedner
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Patent number: 7652048Abstract: Highly concentrated, water-based dispersions of certain lipophilic and/or hydrophobic antimicrobially active materials are stabilized to a surprising degree by a surfactant combination including a nonionic acrylic graft copolymer surfactant and a alkoxylated polyarylphenol phosphate ester surfactant. The active materials may be present in dispersion concentrates of the present invention singly or in useful combinations. The active materials are selected from the group of fungicides and bactericides consisting of 1,2-benzisothiazol-3(2H)-one; 2-octyl-2H-isothiazol-3-one; 5-chloro-2-methyl-2H-isothiazol-3-one; 2-methyl-2H-isothiazol-3-one; pyrithione zinc; 3-iodo-2-propynyl butylcarbamate; 2-methylthio-4-ethylamino-6-tert-butylamino-s-triazine; and 3-(4-isopropylphenyl)-1,1-dimethylurea, and mixtures thereof. The dispersion concentrates may be efficiently shipped and stored, and subsequently diluted with water to produce less concentrated dispersions when desired.Type: GrantFiled: May 4, 2007Date of Patent: January 26, 2010Assignee: Troy CorporationInventors: Werner Bussmann, Burkhard Roessler, Wolfgang Lindner
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Publication number: 20100016381Abstract: The present invention provides an emulsion composition comprising (A) a compound stable in an acidic range, and (B) a buffer, wherein the pH is adjusted from about 3.7 to about 5.5.Type: ApplicationFiled: April 27, 2006Publication date: January 21, 2010Applicant: Takeda Pharmaceutical Company LimitedInventors: Naoki Asakawa, Takayuki Doen
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Publication number: 20100016390Abstract: A stable, low VOC, low viscosity biocide formulation comprising an effective amount of at least one biocide, 1,2-benzisothiazolin-3-one (BIT), and a polyglycol liquid carrier of formula (I): R—O-(AO)n—O—R1, wherein n is 4-25, R and R? are hydrogen, C1-C3 alkyl groups, O?C—CH3 group, or O?C—C2H5 group, and AO is a) CH2CH2O, or b) CH2CH2O/CH2CHMe-O block or random copolymer; with proviso that when R and R? are both hydrogen, AO is a block or random copolymer. A method of making such a formulation.Type: ApplicationFiled: July 23, 2007Publication date: January 21, 2010Inventors: Pierre Marie Lenoir, Irene Siegrist
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Patent number: 7649097Abstract: The present invention relates to novel tetracyclic arylsulfonyl indoles, their derivatives, their analogues, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates, novel intermediates described herein and pharmaceutically acceptable compositions containing them. This invention particularly relates to novel tetracyclic arylsulfonyl indoles of the general formula (I), their derivatives, their analogues, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates, novel intermediates described herein and pharmaceutically acceptable compositions containing them. This invention also relates to process/es for preparing such compound/s of general formula (I), composition/s containing effective amount/s of such a compound and the use of such a compound/composition in therapy.Type: GrantFiled: June 19, 2003Date of Patent: January 19, 2010Assignee: Suven Life Sciences LimitedInventors: Venkateswarlu Jasti, Venkata Satya Nirogi Ramakrishna, Rama Sastri Kambhampati, Srinivasa Reddy Battula, Arava Veeraraeddy, Venkata Satya Veerabhadra Vadlamudi Rao
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Publication number: 20100009848Abstract: The invention provides 3-amino-1,2-benzisothiazole compounds of formula (I) wherein n, R1, R2, R3, R4 and A are defined as in the description.Type: ApplicationFiled: January 14, 2008Publication date: January 14, 2010Applicant: BASF SEInventors: Wolfgang von Deyn, Matthias Pohlman, Florian Kaiser, Joachim Dickhaut, Douglas D. Anspaugh, Deborah L. Culbertson, Hassan Oloumi-Sadeghi
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Publication number: 20090312377Abstract: The invention relates to derivatives of benzo[d]isothiazoles as histone deacetylase inhibitors, selected from among compounds of general formula (Ia) and (Ib) or one of the salts thereof, particularly one of the pharmaceutically acceptable salts thereof, or one of the corresponding solvates thereof. These compounds are histone deacetylase enzyme inhibitors and are suitable as pharmacologically active agents in a medicament for the treatment and/or prophylaxis of disorders or diseases associated to histone deacetylases.Type: ApplicationFiled: June 20, 2007Publication date: December 17, 2009Applicant: UNIVERSIDAD DE GRANADAInventors: Jose Antonio Gomez Vidal, Jose Francisco Dominguez Seglar, Mavys Tabraue Chavez
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Publication number: 20090306157Abstract: An antiseptic preparation is provided for the production of wound dressings or bandages. The preparation includes at least one alginate and at least one antiseptically active substance selected from the group biguanide derivatives, octenidine and taurolidine. Processes for the production of the antiseptic preparations, and the use thereof, are also provided.Type: ApplicationFiled: December 22, 2006Publication date: December 10, 2009Applicant: LOHMANN & RAUSCHER GMBH & CO. KGInventors: Christian Rohrer, Helmut Leuprecht, Iulian Corneliu Alupei
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Patent number: 7618650Abstract: The invention concerns the combination of a short-acting hypnotic agent and a compound of formula (I): Wherein X, Y, Z, A, B, D, Ar, R1 and R2 are as defined herein. The combination of this invention is useful in treating a variety of sleep disorders.Type: GrantFiled: February 6, 2008Date of Patent: November 17, 2009Assignee: Aventis Pharmaceuticals IncInventors: Gary Emmons, Sathapana Kongsamut, Craig N. Karson, Corrine M. Legoff
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Patent number: 7615570Abstract: Compounds having formula (I) or a pharmaceutically acceptable salt, prodrug, or salt of a prodrug thereof, wherein L, A, G, R1, R2 and R3 are as defined herein. These compounds are particularly useful in the treatment of pain, inflammatory hyperalgesia, and urinary dysfunctions, such as bladder overactivity and urinary incontinence.Type: GrantFiled: December 5, 2005Date of Patent: November 10, 2009Assignee: Abbott LaboratoriesInventors: Brian S. Brown, Tammie K. Jinkerson, Ryan G. Keddy, Chih-Hung Lee
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Publication number: 20090270460Abstract: Compounds of formula wherein variables are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and related diseases.Type: ApplicationFiled: May 22, 2007Publication date: October 29, 2009Inventors: Michael Gregory Bell, Robert Anthony Doti, Michael James Genin, Peter Ambrose Lander, Tianwei Ma, Peter Rudolph Manninen, Jason Matthew Ochoada, Fucheng Qu, Lindsay Scott Stelzer, Ryan Edward Stites, Alan M. Warshawsky
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Patent number: 7595403Abstract: A novel class of benzisothiazole-3(2H)-one compounds is disclosed together with the use of such compounds for inhibiting hepatic lipase and/or endothelial lipase activity for treatment, amelioration or prevention of hepatic lipase and/or endothelial lipase mediated diseases.Type: GrantFiled: March 25, 2004Date of Patent: September 29, 2009Assignee: Eli Lilly and CompanyInventors: Patrick Irving Eacho, Patricia Sue Foxworthy-Mason, Ho-Shen Lin, Jose Eduardo Lopez, Marian Kazimierz Mosior, Michael Enrico Richett
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Publication number: 20090209532Abstract: Compounds of formula (I) exhibit COMT enzyme inhibiting activity and are thus useful as COMT inhibitors.Type: ApplicationFiled: July 17, 2006Publication date: August 20, 2009Inventors: Marko Ahlmark, Reijo Backstrom, Anne Luiro, Jarmo Pystynen, Eija Tiainen
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Publication number: 20090203756Abstract: The present invention relates to biocidal compositions comprising at least one biocidal active substance and at least one solvent from the group of polyglycol monobutyl ethers, and to their use as preservatives and disinfectants. More specifically, the invention provides compositions comprising a) at least one biocidal active substance b) at least one solvent according to the formula I R—(O—CH2—CH2)x—O—H??(I) in which R is a linear or branched butyl group and x is a number from 3 to 10.Type: ApplicationFiled: September 6, 2006Publication date: August 13, 2009Inventors: Uwe Falk, Michael Marcus Walter
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Publication number: 20090192154Abstract: A sultam derivative of Formula (1) described below having inhibitory action for aggrecanase activity is provided. The sultam derivative of Formula (1) and a salt thereof exhibit strong inhibitory action for aggrecanase activity in a living body of a mammalian animal including human, and is useful, for example, as an active ingredient of a pharmaceutical agent for preventing and/or treating various diseases caused by degradation of aggrecan.Type: ApplicationFiled: December 23, 2008Publication date: July 30, 2009Applicant: Asahi Kasei Pharma CorporationInventors: Naomi MAEKAWARA, Masakazu Atobe, Masashi Kawanishi, Eiichi Tanaka
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Publication number: 20090156546Abstract: The present invention provides methods and compositions for the prophylaxis of blood cell disorders such as neutropenia, thrombocytopenia, lymphocytopenia, and anaemia. The invention provides methods wherein compositions comprising at least one cytokinin compound are administered either therapeutically or prophylactically. The invention further has utility in methods of DNA repair.Type: ApplicationFiled: May 11, 2007Publication date: June 18, 2009Inventor: Patrick T. Prendergast
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Publication number: 20090155176Abstract: The present invention provides compounds and methods for the treatment of diabetic retinopathy. In particular, LFA-1 antagonists are described herein to be used in the treatment of diabetic retinopathy. One aspect of the invention provides for diagnosis of diabetic retinopathy and administration of a LFA-1 antagonist, after the patient is diagnosed with diabetic retinopathy.Type: ApplicationFiled: October 17, 2008Publication date: June 18, 2009Applicant: SARcode CorporationInventors: John Burnier, Thomas Gadek, Charles Semba
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Publication number: 20090137646Abstract: A 1,2-benzoisothiazole derivative or a salt thereof is not harmful to a crop and is remarkably effective against agricultural or horticultural plant diseases such as Pyricularia oryzae, Septoria nodorum, Pseudoperonospora cubensis and Colletotrichum orbiculare, and an agricultural or horticultural plant disease-controlling agent containing the derivative or its salt as an active ingredient. The 1,2-benzoisothiazole derivative is represented by the general formula [I]: (wherein R1 is a hydrogen atom or a halogen atom, and R2 is a methyl group or a halogen atom), or a salt thereof.Type: ApplicationFiled: April 20, 2007Publication date: May 28, 2009Applicant: KUMIAI CHEMICAL INDUSTRY CO., LTD. and IHARA CHEMICAL INDUSTRY CO., LTD.Inventors: Toshihiro Nagata, Atsushi Kogure, Isao Kaneko, Norihisa Yonekura, Ryo Hanai
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Patent number: 7524842Abstract: This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF-? or combinations thereof.Type: GrantFiled: January 16, 2007Date of Patent: April 28, 2009Assignee: Schering CorporationInventors: Brian J. Lavey, Joseph A. Kozlowski, Guowei Zhou, Ling Tong, Wensheng Yu, Michael K. C. Wong, Bandarpalle B. Shankar, Neng-Yang Shih, M. Arshad Siddiqui, Kristin E. Rosner, Chaoyang Dai, Janeta Popovici-Muller, Vinay M. Girijavallabhan, Dansu Li, Razia Rizvi, Lei Chen, De-Yi Yang, Robert Feltz, Seong Heon Kim
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Publication number: 20090105314Abstract: The present invention provides an agent for the prophylaxis or treatment of complications after coronary-artery bypass surgery or cardiac diseases, autoimmune diseases, central nervous system diseases, inflammatory diseases, sepsis, severe sepsis or septic shock in a patient who undergoes coronary-artery bypass surgery, which comprises a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a compound represented by the formula (II): wherein each symbol is as defined in the specification, or a salt thereof or a prodrug thereof, and an agent for the prophylaxis or treatment of sepsis and the like, as well as complications after coronary-artery bypass surgery, which is prepared for administration of ethyl (6R)-6-[(2-chloro-4-fluoroanilino)sulfonyl]-1-cyclohexene-1-carboxylate or a salt thereof or a prodrug thereof in a specific dose at a specific administration time.Type: ApplicationFiled: May 14, 2007Publication date: April 23, 2009Inventors: Masayuki Ii, Hideyasu Matsuda, Kouji Mouri
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Publication number: 20090105320Abstract: This invention relates to biocidal compositions in the form of solutions, containing a) 1,2-benzisothiazolin-3-one (formula I) and/or a salt thereof, preferably its alkali metal or ammonium salt, in particular its lithium, sodium or potassium salt; b) 1,2-dibromo-2,4-dicyanobutane (formula (II)); c) at least one solvent which is a mixture of a compound of the formula III with glycerol (formula (III)); wherein R1 and R2 are each independently hydrogen or a linear or branched, saturated or unsaturated alkyl group having 1 to 8 carbon atoms, (O-A) is an alkoxy group selected from an ethylenoxy group (EO), propylenoxy group (PO), butylenoxy group and/or phenylethoxy group, x represents a number ranging from 1 to 15 and y represents a number ranging from 0 to 10.Type: ApplicationFiled: February 26, 2007Publication date: April 23, 2009Inventors: Uwe Falk, Michael Marcus Walter
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Publication number: 20090093524Abstract: Compounds of formula (I) wherein variables are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and related diseases.Type: ApplicationFiled: May 22, 2007Publication date: April 9, 2009Inventors: Michael Gregory Bell, Robert Anthony Doti, Matthew Scott Dowling, Michael James Genin, Peter Ambrose Lander, Tianwei Ma, Nathan Bryan Mantlo, Jason Matthew Ochoada, Lindsay Scott Stelzer, Ryan Edward Stites, Alan M. Warshawsky
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Patent number: 7504424Abstract: This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate, ester or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof.Type: GrantFiled: January 17, 2006Date of Patent: March 17, 2009Assignee: Schering CorporationInventors: Wensheng Yu, Ling Tong, Lei Chen, Joseph A. Kozlowski, Brian J. Lavey, Neng-Yang Shih, Vincent S. Madison, Guowei Zhou, Peter Orth, Zhuyan Guo, Michael K. C. Wong, De-Yi Yang, Seong Heon Kim, Bandarpalle B. Shankar, M. Arshad Siddiqui, Kristin E. Rosner, Chaoyang Dai, Umar Faruk Mansoor, Janeta Popovici-Muller, Vinay M. Girijavallabhan, Dansu Li
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Publication number: 20090069317Abstract: The invention relates to insecticidal methods using 3-amino-1,2-benzoisothiazole compounds of the formula (I) wherein the variables n and R1 to R6 are as defined in the description. The invention relates to methods of combating or controlling insects, arachnids or nematodes, to methods for protecting growing plants from attack or infestation by insects, arachnids or nematodes, and to methods for the protection of seeds from soil insects and of the seedlings' roots and shoots from soil and foliar insects.Type: ApplicationFiled: November 15, 2006Publication date: March 12, 2009Applicant: BASF SEInventors: Matthias Pohlman, Wolfgang von Deyn, Florian Kaiser, Michael Rack, Henricus Maria Martinus Bastiaans, Douglas D. Anspaugh, Deborah L. Culbertson, Henry Van Tuyl Cotter
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Publication number: 20090062355Abstract: An agent for suppressing the production of various cytokines (IL-8 and the like) and inflammatory mediators, an agent for suppressing the expression of COX-II and the like, or an inhibitor of various phosphorylation enzymes (ATF2 and the like), which contains a TLR signaling inhibitory substance, preferably a compound represented by the formula (I) or the formula (II) wherein each symbol is as defined in the specification, or a salt thereof or a prodrug thereof.Type: ApplicationFiled: April 19, 2007Publication date: March 5, 2009Inventors: Yuji Iizawa, Masayuki Ii, Tomohiro Kawamoto
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Patent number: 7495020Abstract: A class of 2-aryloxy-2-arylalkanoic acids comprises compounds that are potent agonists of PPAR alpha and/or gamma, and are therefore useful in the treatment, control or prevention of non-insulin dependent diabetes mellitus (NIDDM), hyperglycemia, dyslipidemia, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, atherosclerosis, obesity, vascular restenosis, inflammation, and other PPAR alpha and/or gamma mediated diseases, disorders and conditions.Type: GrantFiled: January 18, 2006Date of Patent: February 24, 2009Assignee: Merck & Co., Inc.Inventors: Alan D. Adams, A. Brian Jones, Joel P. Berger, James F. Dropinski, Alexander Elbrecht, Kun Liu, Karen Lamb MacNaul, Guo-Qiang Shi, Derek J. Von Langen, Gaochao Zhou
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Patent number: 7488745Abstract: This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate, ester or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof.Type: GrantFiled: January 16, 2007Date of Patent: February 10, 2009Assignee: Schering CorporationInventors: Wensheng Yu, Ling Tong, Lei Chen, Joseph A. Kozlowski, Brian J. Lavey, Neng-Yang Shih, Vincent S. Madison, Guowei Zhou, Peter Orth, Zhuyan Guo, Michael K. C. Wong, De-Yi Yang, Seong Heon Kim, Bandarpalle B. Shankar, M. Arshad Siddiqui, Kristin E. Rosner, Chaoyang Dai, Janeta Popovici-Muller, Vinay M. Girijavallabhan, Dansu Li, Razia Rizvi, Aneta M. Micula, Robert Feltz
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Patent number: 7482370Abstract: This invention relates to compounds of the Formula (I): or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, TNF- or combinations thereof.Type: GrantFiled: July 13, 2005Date of Patent: January 27, 2009Assignee: Schering CorporationInventors: Wensheng Yu, Ling Tong, Lei Chen, Joseph A. Kozlowski, Brian J. Lavey, Neng-Yang Shih, Vincent S. Madison, Guowei Zhou, Peter Orth, Zhuyan Guo, Michael K. C. Wong, De-Yi Yang, Seong Heon Kim, Bandarpalle B. Shankar