Abstract: The invention relates to a method for extracting mycotoxins from grain and other food products or from feed and its subsequent quantification. Fields of application are the food industry, the animal feed industry or biotechnology. The objective of the present invention is to develop an extraction method with which it is possible to uniformly extract mycotoxins with different dissolving properties. It was found that with the aid of aqueous, buffered naphthyl and/or phenyl compounds or their heterocyclical analogues, both hydrophobic and hydrophilic mycotoxins can be extracted. The method according to the invention is characterized in that the buffered solutions of naphthyl and/or phenyl compounds and/or their heterocyclical analogues, which carry at least one sulphonic acid or at least one carbonate acid group, are brought into contact with the grain or other food products or animal feed, the aqueous solution is then separated and the content of the extracted mycotoxins in the aqueous solution is determined.

Abstract: A method effective in treating a viral infection involves administering a therapeutically effective amount of at least one compound capable of inhibiting expression of at least a portion of a virus genome containing an internal ribosomal entry site, or a pharmaceutically acceptable salt thereof. The compound has an azole moiety comprising a five member heterocyclic ring containing at least one nitrogen atom, a hydrophobic moiety bonded to the heterocyclic ring of the azole, and a donor/acceptor moiety bonded to the heterocyclic ring having at least one of hydrogen bond donor and a hydrogen bond acceptor.

Abstract: Embodiments of the present invention relate to solvents for agricultural applications and pesticide formulations. In one aspect, a solvent for agricultural applications comprises (a) a first component consisting of a polar solvent wherein the polar solvent is a sulfoxide, N-methyl-2-pyrrolidone, ?-butyrolactone, or a combination thereof; (b) a second component consisting of a glycol ether, and (c) a third component consisting of an ether ester of Formula 1: wherein R1 and R2 are each independently one of an alkyl group having 1 to 4 carbon atoms or an aryl group, wherein R3 is hydrogen, methyl, or ethyl, and wherein n is 1 to 6.

Abstract: The present invention relates to a derivative compound in which a biphenyl group is introduced into an aminoalkanoic acid, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof. The compound of the present invention exhibits excellent antifungal and fungicidal effects. Furthermore, the compound of the present invention exhibits a synergistic effect when used in combination with a conventional antifungal agent. Furthermore, the compound of the present invention provides broad-spectrum antifungal activity against a wide range of fungal pathogens. Therefore, the compound of the present invention may be widely used in fields requiring treatment with antifungal or fungicidal agents against human pathogenic fungi and animal pathogenic fungi, and phytopathogenic fungi.

Abstract: A method is provided herein to increase an immune response to an antigen. The method includes administering an agent that inhibits extracellular adenosine or inhibits adenosine receptors. Also disclosed are methods to increase the efficacy of a vaccine and to increase an immune response to a tumor antigen or immune cell-mediated tumor destruction.

Abstract: The present invention comprises methods of treating an infection using a pharmaceutical composition comprising an active ingredient selected from Table 1. In some aspects, the infection can be caused by one or more pathogens, including fungal pathogens. For example, the infection may be Valley Fever.

Abstract: The invention provides novel compounds having the general formula (I) wherein RA, RB, RC, RC1 and W are as defined herein, compositions including the compounds and methods of using the compounds.

Abstract: The decrease in soybean rust control using fungicide mixtures (DMAs+QoIs) reached very low levels for the harvest of 2012/13 (an average of 37% for the three main mixtures). This decrease is due to a decrease in Pp sensitivity to individual DMIs and QoIs, and mixtures thereof. Anti-resistance strategies have not been introduced in Brazil for preventing/delaying the development of resistance of the fungus that is the causal agent of rust (Phakopsora pachyrhizi) in soybean [plant form the family Fabaceae, Glycine max (L.) Merr.] and of the fungus that is the casual agent of yellow leaf spot (Drechslera tritici-repentis) in wheat [plant of the family Triticea, Triticum aestivum L.], as well as other disease complexes that attack the main crop plants in Brazil, such as corn, beans, cotton, inter alia. By means of said method it is possible to recover the efficiency of several mixtures (DMI+QoI and QoI+SDHI) due to a decrease in fungal sensitivity.

Abstract: Disclosed herein, inter alia, are agents having antiviral activity and methods of use thereof.

Abstract: The present invention relates to a method for inhibiting lung diseases in smokers and non-smokers by blocking growth factor signaling using an antihypertensive drug, and more particularly, to a pharmaceutical composition for preventing lung cancer or emphysema, which contains an antihypertensive drug as an active ingredient. The present invention suggests a novel use of an antihypertensive drug which is being used in clinics, to prevent lung diseases, and therefore, may be readily applied to early lung cancer or a lung cancer high-risk group, and particularly may exclude safety concerns accompanying clinical application of novel drugs, thereby increasing clinical applicability. In addition, enormous costs and time needed from development to clinical use of new drugs may be dramatically reduced.

Abstract: Embodiments are directed to a secnidazole formulations and the use of a secnidazole formulation for the treatment of bacterial vaginosis (BV).

Abstract: The present invention relates to the novel use of the pyrazole carboxylic acid amide derivative Pydiflumetofen, compositions comprising this compound and its use in methods for the reduction of mycotoxin contamination in plants. Pydiflumetofen is also useful in increasing yield, in particular in cereals eg. wheat.

Abstract: Embodiments are directed to a secnidazole formulations and the use of a secnidazole formulation for the treatment of bacterial vaginosis (BV).

Abstract: Agents and methods of inhibiting or improving the growth of viruses are provided.

Abstract: A water dispersible granular composition comprising: at least one solid agrochemically active substance; at least one sorptive filler; at least one first agrochemically acceptable excipient; at least one liquid or low melting agrochemically active substance; and, at least one second agrochemically acceptable excipient. The invention further relates to a process of preparing the water dispersible granular composition.

Abstract: Techniques to profile a disease or a disorder (e.g., a tumor) based on a protein activity signature are disclosed herein. An example method can include measuring quantitatively protein activity of a plurality of master regulator proteins in a sample from a disease or disorder; and profiling the tumor from the quantitative protein activity of the master regulator proteins. Also disclosed are methods of identifying a compound or compounds that treats diseases or disorders (e.g., inhibit tumor cell growth).

Abstract: Compounds of Formula (I) and Formula (II), pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and have use in treating cardiovascular and other conditions. Compounds of Formula (I) and Formula (II) have the following structures: (I); (II). Intermediates (V) are also claimed.

Abstract: The present disclosure provides methods for treating a mammal that has endometriosis using a CHRH1 antagonist composition. In some embodiments, the CHRH1 antagonist is antalarmin or an equivalent.

Abstract: The present invention comprises methods of treating an infection using a pharmaceutical composition comprising an active ingredient selected from Table 1. In some aspects, the infection can be caused by one or more pathogens, including fungal pathogens. For example, the infection may be Valley Fever.

Abstract: The invention provides novel compounds having the general formula (I) wherein RA, RB, RC, RC1 and W are as defined herein, compositions including the compounds and methods of using the compounds.

Abstract: Compounds having General Formula (I) or General Formula (II): in which R1 is chosen from C1 to C10 aliphatic or heteroaliphatic groups, optionally substituted with one or more aryl groups, substituted aryl groups, heteroaryl groups, substituted heteroaryl groups, or combination thereof, R2 is chosen from aromatic moieties, substituted aromatic moieties, heteroaromatic moieties, substituted heteroaromatic moieties, and coumarin; R3 is chosen from —H, C1 to C10 aliphatic or heteroaliphatic groups, phenyl, or substituted phenyl, wherein the aliphatic or heteroaliphatic groups are optionally substituted with one or more phenyl groups, aryl groups, heteroaryl groups, substituted heteroaryl groups, or combination thereof, and wherein the aliphatic or heteroaliphatic groups are optionally bonded to R2 to form a ring; X is S or O; and Y is S or NH, may be used in pharmaceutical compositions that modify of biological signaling processes or as reagents for biological assays.

Abstract: The present invention relates to compounds of formula (I): and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the compounds of formula I or their pharmaceutically acceptable salts, and methods of using said compounds, salts and compositions in the treatment of various disorders associated with CRM1 activity.

Abstract: The present invention provides a plant disease control composition that has excellent plant disease controlling effects and that contains a tetrazolinone compound represented by formula (1) [wherein X1 represents a halogen atom or the like and X2 represents a C1-C3 alkyl group or the like] and an azole compound represented by formula (2) [wherein R1 represents a C1-6 alkyl group, R2 represents a hydrogen atom or the like, A represents a nitrogen atom or the like, Y1 represents a halogen atom, and n is 0 or 1]. The present invention also provides a plant disease control method that includes a step for treating a plant or the soil in which a plant is being cultivated with an effective dose of the tetrazolinone compound represented by formula (1) and of the azole compound represented by formula (2).

Abstract: A pharmaceutical combination comprising a platinum-containing anticancer agent, and an Hsp90 inhibitor according to the following formulae (I) & (Ia), a tautomer, or a pharmaceutically acceptable salt thereof, wherein the variables structural formulae are defined herein. Also provided is a method of treating a proliferative disorder such as cancer in a subject in need thereof, using the pharmaceutical combination described herein.

Abstract: The decrease in soybean rust control using fungicide mixtures (DMAs+QoIs) reached very low levels for the harvest of 2012/13 (an average of 37% for the three main mixtures). This decrease is due to a decrease in Pp sensitivity to individual DMIs and QoIs, and mixtures thereof. Anti-resistance strategies have not been introduced in Brazil for preventing/delaying the development of resistance of the fungus that is the casual agent of rust (Phakopsora pachyrhizi) in soybean [plant form the family Fabaceae, Glycine max (L.) Merr.] and of the fungus that is the casual agent of yellow leaf spot (Drechslera tritici-repentis) in wheat [plant of the family Triticea, Triticum aestivum L.], as well as other disease complexes that attack the main crop plants in Brazil, such as corn, beans, cotton, inter alia. By means of said method it is possible to recover the efficiency of several mixtures (DMI+QoI and QoI+SDHI) due to a decrease in fungal sensitivity.

Abstract: A combination comprising a multi-site contact fungicide, a first systemic fungicide and optionally a second systemic fungicide and a method using the same.

Abstract: Methods of controlling the feeding and/or breeding behavior of a target insect are disclosed in which a host plant is provided a substantial distance from a plant of interest, chemical attractant that induces the target insect to lay eggs on the host plant is applied to the host plant, application of the chemical attractant to the host plant is repeated as required to induce residual target-insect populations to lay eggs on the host plant, and wherein the behavior is controlled when a substantial number of offspring belonging to subsequent generations themselves mature and display a preference for laying eggs on the same type of host plant on which they were reared without further application of the chemical attractant is provided. Also disclosed are methods of deterring target insect feeding and breeding on plants of interest by applying toxic plant extract to the plants of interest.

Abstract: The invention relates to solid forms of cenicriviroc mesylate, methods of their preparation, pharmaceutical compositions thereof and methods of their use.

Abstract: Safeners for herbicides are suitable for increasing the microbicidal activity of fungicides.

Abstract: A method of promoting remyelination in a subject in need thereof includes administering to the subject a therapeutically effective amount of at least one (1,3) Diazole compound, wherein the therapeutically effective amount is the amount effective to induce endogenous oligodendrocyte precursor cell (OPC) differentiation in the subject's central nervous system.

Abstract: A matrix composition capable of forming an emulsion/micro-emulsion comprising an emulsifiable matrix, essentially free of alkyl pyrrolidone and alkoxylated alcohol, comprising: (i) a long chain substituted amide; (ii) a surface active agent; and (iii) optionally, an organic diluent.

Abstract: Disclosed are two axially chiral isomers and pharmaceutically available salts thereof, preparation method therefor, and pharmaceutical use of the two axially chiral isomers or pharmaceutical compositions thereof.

Abstract: The present invention relates to compounds of the formula I wherein the variables are defined in the description and claims, their preparation and uses thereof.

Abstract: The present invention relates to a compound represented by formula (E). The present invention also relates to a compound represented by the formula (E) for use in the treatment or prevention of diseases linked to protein aggregation and/or neurodegenerative diseases. Moreover, the present invention relates to pharmaceutical and diagnostic compositions comprising the compound of the invention as well as to a kit. Furthermore, the present invention relates to a method of imaging deposits of aggregated protein. A kit for preparing a detectably labelled compound of the present invention is also disclosed.

Abstract: The present invention provides a new cyclic compound having a CCR antagonist activity, especially a CCR5 antagonist activity, and the use thereof. The compound of the present invention is represented by the formula: wherein, R1 is a 5- to 6-membered ring group which may be substituted; X1 is a bond or the like; ring A is a 5- to 6-membered ring group which may be substituted; ring B is a 8- to 10-membered ring group which may be substituted; X2 is a bivalent group of 1 to 4 atom; Z1 is a bivalent cyclic ring group or the like; Z2 is a bond or the like; and R2 is an amino group, a nitrogen-containing heterocyclic group which may be substituted or the like, or a salt thereof.

Abstract: Methods, compounds and kits relating to treating cancer, reducing kinase inhibitor or resistance, and reducing or preventing diminished ectodomain shedding are described.

Abstract: The present invention relates to the field of reagents for oil and gas wells, and discloses a plugging agent for improving bearing capacity and a preparation method of the plugging agent, wherein, the plugging agent contains water, bridging granules, packing granules, and a cementing material, and, based on 100 parts by weight of water, the content of the bridging granules is 3-15 parts by weight, the content of the packing granules is 5-23 parts by weight, and the content of the cementing material is 4-11 parts by weight. The plugging agent in the present invention can improve the bearing capacity of the formation during well plugging, is applicable to shielded temporary plugging against serious leakage loss during extra-deep well drilling, has efficient and quick plugging performance, and is especially applicable to plugging against serious leakage loss in a formation where the well depth is greater than 3,000 m and conventional plugging agents can't attain a satisfactory plugging effect.

Abstract: Crystalline polymorph forms of 2-(5-bromo-4-(4-cyclopropyl naphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)acetic acid are described. Pharmaceutical compositions and the uses of such compounds, compound forms, and compositions for the treatment of a variety of diseases and conditions are also presented.

Abstract: The present invention relates to novel mixtures, to processes for preparing these compounds, to compositions comprising these mixtures, and to the use thereof as biologically active compounds, especially for control of harmful microorganisms in crop protection and in the protection of materials and for enhancing plant health.

Abstract: The present invention relates to methods and pharmaceutical compositions for the treatment of beta-thalassemias. In particular, the present invention relates to an XPO1 inhibitor for use in a method for treating beta-thalassemia in a subject in need thereof.

Abstract: A preformed concentrate, capable of forming emulsion/micro-emulsion upon dilution with water, for providing peripheral desiccating effect on leaves/crops comprising: (i) a water insoluble film forming polymer; (ii) a long chain substituted amide; and (iii) an oil soluble surfactant.

Abstract: The present invention discloses compounds of Formula I: wherein the variables in Formula I are defined as described herein. Also disclosed are pharmaceutical compositions containing such compounds and methods for using the compounds of Formula I in the prevention or treatment of HCV infection.

Abstract: A fungicidal composition containing, as active ingredients, (a) a benzoylpyridine derivative represented by the following formula or its salt: wherein X is a halogen atom, a nitro group, a substitutable hydrocarbon group, a substitutable alkoxy group, a substitutable aryloxy group, a substitutable cycloalkoxy group, a hydroxyl group, a substitutable alkylthio group, a cyano group, a carboxyl group which may be esterified or amidated, or a substitutable amino group, n is 1, 2, 3 or 4; R1 is a substitutable alkyl group, R2? is a substitutable alkyl group, a substitutable alkoxy group, a substitutable aryloxy group, a substitutable cycloalkoxy group or a hydroxyl group, p is 1, 2 or 3, and R2? is a substitutable alkoxy group or a hydroxyl group, provided that at least two of R2? and R2? optionally form a condensed ring containing an oxygen atom and (b) at least one other fungicide.

Abstract: The present invention provides a method for producing a co-crystal including thiophanate-methyl and a triazole-based compound such as tebuconazole and a method for producing an agricultural and horticultural chemical preparation using the co-crystal as a raw material. As one example, the agricultural and horticultural chemical preparation can be obtained by a method including the steps of obtaining a sol including a co-crystal by stirring a suspension including thiophanate-methyl, a triazole compound such as a tebuconazole, a surfactant, a defoaming agent and water at a mixing degree of 0.1-1.0 while holding the temperature of the suspension at 60° C.; and adding auxiliary components such as silica, calcium carbonate and the like to the sol.

Abstract: The present invention provides a method for producing a co-crystal including thiophanate-methyl and a triazole-based compound such as tebuconazole and a method for producing an agricultural and horticultural chemical preparation using the co-crystal as a raw material. As one example, the agricultural and horticultural chemical preparation can be obtained by a method including the steps of obtaining a sol including a co-crystal by stirring a suspension including thiophanate-methyl, a triazole compound such as a tebuconazole, a surfactant, a defoaming agent and water at a mixing degree of 0.1-1.0 while holding the temperature of the suspension at 60° C.; and adding auxiliary components such as silica, calcium carbonate and the like to the sol.

Abstract: The present invention relates to compounds of formula (I), wherein A, B, R1 and R2 are as defined herein before useful for the treatment of psychiatric disorders.

Abstract: A stable matrix emulsion concentrate of a biocide, e.g. 3-iodopropynyl-2-butyl carbamate (IPBC) and/or a triazole fungicide, and stable aqueous and/or organic solvent formulations thereof, i.e. dilutable in water and/or an organic solvent are provided, which are particularly useful for treating wood products to provide protection against microorganisms and insects.

Abstract: The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.

Abstract: The invention discloses optically active compounds of Formula (1a) or Formula (1b), wherein R1 and R2 are independently selected from the group consisting of hydrogen and a halogen selected from the group consisting of fluorine, chlorine, bromine, and iodine; and wherein (a) R3 and R4 are independently selected from the group consisting of hydrogen and an alkyl group having a linear or branched chain having 1 to 20 carbon atoms, or (b) R3 and R4 together form a cycloalkyl ring having 3 to 10 carbon atoms fused to the thiophene ring; and wherein R5 is CN or COOR?, where R? is methyl or ethyl. The compounds of Formula (1a) or Formula (1b) may be used in pharmaceutical compositions for treating fungal infections.

Abstract: The invention relates to low-dose pharmaceutical compositions comprising the aromatase inhibitor 4,4?-[fluoro-(1-H-1,2,4-triazol-1-yl)methylene]bisbenzonitrile, as the active ingredient in a suitable carrier. The present invention also relates to a process for their preparation and to their use as therapeutic agents.