Divalent Chalcogen Or Acyclic Nitrogen Double Bonded Directly To Ring Carbon Of The Diazole Ring, Or Tautomeric Equivalent Patents (Class 514/404)
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Publication number: 20030219718Abstract: Compounds that bind S100 and inhibit the S100-p53 protein-protein interaction and activate the tumor suppressor activity of p53, and thus which have an antineoplastic effect are disclosed, as well as methods for identifying these compounds, compositions comprising the same, and methods of using the same to treat cancer.Type: ApplicationFiled: March 27, 2003Publication date: November 27, 2003Applicant: UNIVERSITY OF MARYLAND, BALTIMOREInventors: David J. Weber, Joseph Markowitz, France Carrier, Alexander D. MacKerell
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Publication number: 20030212116Abstract: A heterocyclic imino compound of the formula (1) and an agrochemically acceptable salt thereof; and an agricultural chemical, fungicide and insecticide containing at least one member selected from the group of such compounds as an active ingredient: 1Type: ApplicationFiled: June 25, 2002Publication date: November 13, 2003Inventors: Toshio Niki, Takashi Mizukoshi, Hiroaki Takahashi, Jun Satow, Tomoyuki Ogura, Kazuhiro Yamagishi, Hiroyuki Suzuki, Fumio Hayasaka
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Publication number: 20030207874Abstract: Compounds of formula (I), (IIa) or (IIb) wherein R1-R6, Z, Q and n are as defined in claim 1 and their pharmaceutically acceptable salts are ligands at gastrin and/or cholecystokinin receptors. Compositions comprising a compound of formula (I), (IIa) or (IIb) are also described.Type: ApplicationFiled: April 23, 2003Publication date: November 6, 2003Inventors: Iain Mair McDonald, Caroline Minli Rachel Low, Katherine Isobel Mary Steel, John Spencer
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Patent number: 6638956Abstract: The invention relates to novel 1-arylpyrazole oxime derivatives, of general formula (I) or (I bis) These compounds are found to be generally safe systemic insecticides for control of arthropod, nematode, helminth or protozoan pests including compositions and derivatives thereof.Type: GrantFiled: July 18, 2002Date of Patent: October 28, 2003Assignee: Rhone-Poulenc, Inc.Inventors: Tai-Teh Wu, Alain Chene, David Treadway Manning, Peter Wyatt Newsome, Nicholas Charles Ray, Jennifer Lantz Phillips, Patrick Doyle Lowder
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Publication number: 20030199563Abstract: aP2 inhibiting compounds are provided having the formula 1Type: ApplicationFiled: December 17, 2002Publication date: October 23, 2003Inventors: Jeffrey A. Robl, David R. Magnin
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Patent number: 6617342Abstract: This invention provides compounds and their pharmaceutically acceptable salts, pharmaceutical formulation of said compounds and methods for treating hyperglycemia associated with non-insulin dependant diabetes and for treating hyperlipidemia.Type: GrantFiled: April 16, 2002Date of Patent: September 9, 2003Assignee: Eli Lilly and CompanyInventor: Samuel James Dominianni
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Publication number: 20030162775Abstract: The present invention is directed to novel heterocyclic substituted pyrazolones, including pharmaceutical compositions, diagnostic kits, assay standards or reagents containing the same, and methods of using the same as therapeutics. The invention is also directed to intermediates and processes for making these novel compounds.Type: ApplicationFiled: August 22, 2002Publication date: August 28, 2003Applicant: Cephalon, Inc.Inventors: Jasbir Singh, Rabindranath Tripathy
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Patent number: 6608077Abstract: This invention relates to novel compounds of Formula (I) to (VII), and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).Type: GrantFiled: September 5, 2002Date of Patent: August 19, 2003Assignee: SmithKline Beecham CorporationInventors: Katherine Louisa Widdowson, Qi Jin
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Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use
Patent number: 6593347Abstract: The present invention describes novel nitrosated and/or nitrosylated nonsteroidal antiinflammatory compounds, and novel compositions comprising at least one nitrosated and/or nitrosylated nonsteroidal antiinflammatory compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase. The present invention also provides methods for treating, preventing and/or reducing inflammation, pain, and fever; decreasing or reversing the gastrointestinal, renal and other toxicities resulting from the use of nonsteroidal antiinflammatory drugs; treating and/or preventing gastrointestinal disorders; treating inflammatory disease states and disorders; and treating and/or preventing ophthalmic diseases or disorders.Type: GrantFiled: August 27, 2001Date of Patent: July 15, 2003Assignee: NitroMed, Inc.Inventors: Upul K. Bandarage, Qing Dong, Xinqin Fang, David S. Garvey, Gregory J. Mercer, Stewart K. Richardson, Joseph D. Schroeder, Tiansheng Wang -
Patent number: 6589973Abstract: A clear, stable novel pharmaceutical preparation of selective cyclooxygenase II inhibitors (COX 2) inhibitors in the parenteral form for the treatment of pain & inflammatory conditions arising because of cyclooxygenase-2 activity. In particular the pharmaceutical preparation of COX 2 inhibitors comprise of selective active COX 2 inhibitors selected from Celeoxib, Rofecoxib and their analogs dissolved in a selective isosorbide type solvent of following general formula I where R1 and R2 are hydrogen or alkyl chains containing 1-3 carbons or acetate group. Also disclosed is a simple and cost effective process of manufacture of the above novel pharmaceutical preparation.Type: GrantFiled: May 15, 2002Date of Patent: July 8, 2003Assignee: THEMIS Medicare Ltd.Inventors: Dinesh Shantilal Patel, Sachin Dinesh Patel, Shashikant Prabhudas Kurani
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Patent number: 6576632Abstract: The present invention relates to compounds of formula I and to pharmaceutically acceptable salts, hydrates and prodrugs thereof, wherein R1, R2, R3, R4, R5, R10, R11, b, m, n, p and v are as defined herein. The invention also relates to pharmaceutical compositions containing the above compounds and methods of treating hyperproliferative disorders in mammals by administering the above compounds.Type: GrantFiled: April 13, 2000Date of Patent: June 10, 2003Assignee: Pfizer IncInventors: Steven W. Goldstein, Kelly P. Longo, James F. Blake, Mohamed M. A. Awad, Kenneth P. Raiche, Kevin W. Kramer
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Publication number: 20030100585Abstract: The present invention is directed to a genus of non-peptidyl compounds, wherein said compounds are VLA-4 inhibitors useful in treating inflammatory, autoimmune, and respiratory diseases, and wherein said compounds comprise a compound of Formula (1.0.Type: ApplicationFiled: June 12, 2002Publication date: May 29, 2003Inventors: Allen J. Duplantier, Louis S. Chupak, Anthony J. Milici, Wan F. Lau
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Patent number: 6569885Abstract: Pyrazole compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.Type: GrantFiled: October 19, 2000Date of Patent: May 27, 2003Assignee: Icos CorporationInventors: Timothy J. Martins, Kerry W. Fowler, Carmen C. Hertel, Amy Oliver
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Patent number: 6559175Abstract: A method of protecting a corn plant from destructive insects which comprises applying to the seed from which it grows or the soil from which the seed grows a composition comprising an insecticidal 1-arylpyrazole and an insect repellent. A composition comprising the insecticidal 1-arylpyrazole and the repellent.Type: GrantFiled: September 15, 1999Date of Patent: May 6, 2003Assignee: Bayer CropScience Inc.Inventor: Keith A. Holmes
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Patent number: 6559173Abstract: The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.Type: GrantFiled: September 26, 2002Date of Patent: May 6, 2003Assignee: Allergan, Inc.Inventors: Steven W. Andrews, Julie A. Wurster
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Patent number: 6552063Abstract: A formulation for delivery of phenylbutazone for the treatment of equine ailments is disbursed homogeneately in a powdered carrier agent having a flavoring agent and a coloring agent in an amount of from 5 to 49.9 percent by weight of the formulation.Type: GrantFiled: August 3, 2001Date of Patent: April 22, 2003Inventor: George Green
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Patent number: 6552051Abstract: Novel compounds are provided having the structural formula R[—N(NO2)—L—R1]n wherein R, L, R1 and n are defined herein. The compounds are useful in a variety of contexts, but are primarily to be used as high energy oxidizing agents in explosive compositions, propellant formulations, gas-generating compositions and the like. The compounds are also useful as pharmaceutical agents. Compositions containing the compounds are also provided, including energetic compositions, as are methods for using the novel compounds and compositions.Type: GrantFiled: June 7, 2001Date of Patent: April 22, 2003Assignee: SRI InternationalInventors: Jeffrey C. Bottaro, Robert J. Schmitt, Mark A. Petrie, Paul E. Penwell
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Patent number: 6548528Abstract: Process for the protection of a building that has already been built or is going to be built, whereby an effective amount of an insecticidally active compound is spread around or under the said building at discrete locations. The insecticide may be an arylpyrazole.Type: GrantFiled: May 24, 2002Date of Patent: April 15, 2003Assignee: Rhone-Poulenc AgroInventor: Yasuo Kimura
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Patent number: 6538014Abstract: A process for the treatment of grasslands against insects, comprising applying an effective quantity of 1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-3-cyano-4-[(trifluoromethyl)-sulphinyl]-5-aminopyrazole to the grasslands.Type: GrantFiled: January 6, 1995Date of Patent: March 25, 2003Assignee: Bayer CropScience, Inc.Inventors: Ely Vea, Francois Colliot
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Patent number: 6531478Abstract: Amino pyrazole derivatives of the formula: which are ligands for the neuropeptide Y, subtype 5 receptor and pharmaceutical compositions containing an amino pyrazole derivative as the active ingredient are described. The amino pyrazole derivatives are useful in the treatment of disorders and diseases associated with the NPY receptor subtype Y5.Type: GrantFiled: February 22, 2001Date of Patent: March 11, 2003Inventors: Cheryl P. Kordik, Scott L. Dax, Chi Luo, Allen B. Reitz, James J. McNally, Timothy W. Lovenberg
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Patent number: 6531449Abstract: The invention provides metabolites of the compound 2-amino-N-[2-(3a(R)-benzyl-2-methyl-3-oxo-2,3,3a,4,6,7-hexahydro-pyrazolo-[4,3-c]pyridin-5-yl)-1-(R)-benzyl-oxymethyl-2-oxo-ethyl]-isobutyramide, the racemic-diastereomeric mixtures and optical isomers thereof, the prodrugs thereof, and the pharmaceutically acceptable salts of the metabolites, racemic-diastereomeric mixtures, optical isomers, and prodrugs; to pharmaceutical compositions thereof; and to methods of using the metabolites and the compositions in the treatment of diseases associated with reduced levels of growth hormone.Type: GrantFiled: March 8, 2001Date of Patent: March 11, 2003Assignee: Pfizer Inc.Inventors: S. Cyrus Khojasteh, John P. O'Donnell
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Patent number: 6521568Abstract: The present invention relates to a plant diseases controlling composition containing as active ingredients: the pyrazolinone derivative represented by Chemical Formula: wherein R1 represents halogen or methyl optionally substituted with halogen, R2 represents hydrogen, halogen or methyl optionally substituted with halogen, R3 represents isopropyl, sec-butyl, 1-ethylpropyl, 1-methylbutyl, tert-butyl or 1,1-dimethylpropyl, R4 representing oxygen or sulfur, R5 represents C1-C5 alkyl, C2-C5 alkynyl or C3-C5 alkenyl, and at least one imide compound selected from N-(3,5-dichlorophenyl)-1,2-dimethylcyclopropane-1,2-dicarboximide, 3-(3,5-dichlorophenyl)-N-(1-methylethyl)-2,4-dioxo-1-imidazolidinecarboxamide and 3-(3,5-dichlorophenyl)-5-methyl-5-vinyl-1,3-oxazolidine-2,4-dione; and a plant diseases controlling method comprising applying said pyrazolinone derivative with said imide compound. The present invention can effectively control plant diseases.Type: GrantFiled: April 19, 2002Date of Patent: February 18, 2003Assignee: Sumitomo Chemical Company, LimitedInventor: Norio Kimura
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Patent number: 6518266Abstract: The present invention is directed to novel pyrazole derivatives and their use as pesticidal agents. The pyrazole derivatives have Formula I: or a salt thereof, where R1 represents R5O, R5SO2, R5SO or R5S in which R5 is as defined herein; X is halo, cyano, C1-6 alkoxycarbonyl, C2-6 alkynyl, optionally substituted C6-14 aryl or an optionally substituted 5- to 7-membered heteroaromatic ring linked to thiazole via a carbon-carbon bond; R2 is hydrogen, amino, chloro, bromo, iodo, cyano, C1-6 alkoxy, C1-6 alkyl or C6-10 aryl; and R3-R7 each represent hydrogen, halogen, straight- or branched-chain C1-4 alkyl or C1-4 alkoxy, either of which is unsubstituted or substituted by one or more halogen atoms, straight- or branched-chain C1-4 alkylthio or C1-4 alkylsulphinyl, either of which is substituted by one or more halogen atoms, nitro, cyano, or straight- or branched-chain C1-4 alkylsulphonyl group which is unsubstituted or substituted by one or more halogen atoms.Type: GrantFiled: July 21, 2000Date of Patent: February 11, 2003Assignees: 3-Dimensional Pharmaceuticals, Heska CorporationInventors: Daljit S. Dhanoa, Dario Doller, Sanath Meegalla, Richard M. Soll, Nancy Wisnewski, Gary Silver, Dan T. Stinchcomb, R. Lee Seward, Dimitris Agrafiotis, Deyou Sha
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Patent number: 6500850Abstract: The invention relates to novel 1-arylpyrazole oxime derivatives, of general formula (I) or (I bis) These compounds are found to be generally safe systemic insecticides for control of arthropod, nematode, helminth or protozoan pests including compositions and derivatives thereof.Type: GrantFiled: October 5, 2001Date of Patent: December 31, 2002Assignee: Rhone-Poulenc Inc.Inventors: Tai-Teh Wu, Alain Chene, David Treadway Manning, Peter Wyatt Newsome, Nicholas Charles Ray, Jennifer Lantz Phillips, Patrick Doyle Lowder
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Patent number: 6492357Abstract: Compositions and methods for controlling insect populations, in particular, insects which attack rice crops, are disclosed. The compositions include one or more compounds from the Formula 1A and one or more compounds from the formulas 1B-G described in the specification, and optionally but preferably include a suitable carrier.Type: GrantFiled: September 13, 2000Date of Patent: December 10, 2002Assignee: Aventis CropScience, S.A.Inventors: Norihiko Nakakura, Philip R. Timmons
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Patent number: 6475526Abstract: One aspect of the invention relates to anti-viral composition containing at least one zinc compound and at least one phenolic antioxidant (and optionally other ingredients such as at least one analgesic) at least one hydrocarbyl containing compound, and water. Another aspect of the invention relates to a method of treating lesionous symptoms of a viral infection involving applying an effective amount of the zinc containing anti-viral composition to the lesions.Type: GrantFiled: June 5, 2001Date of Patent: November 5, 2002Inventor: Jeffrey B. Smith
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Patent number: 6472417Abstract: The present invention provides an insecticidal composition comprising, as active ingredients, (a) at least one pyrethroid compound and (b) an N-arylpyrazole compound such as 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylsulfmylpyrazole, and an insecticidal method which comprises applying the composition.Type: GrantFiled: June 20, 2002Date of Patent: October 29, 2002Assignee: Rhone-Poulenc AgrochimieInventors: Hiroshi Kodama, Yasuhiro Wada, Rikio Yamaguchi
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Patent number: 6462044Abstract: The present invention describes novel nitrosated and/or nitrosylated phosphodiesterase inhibitors, and novel compositions containing at least one nitrosated and/or nitrosylated phosphodiesterase inhibitor, and, optionally, one or more compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, stimulate endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or one or more vasoactive agents. The present invention also provides novel compositions containing at least one phosphodiesterase inhibitor, and one or more compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, stimulate endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or one or more vasoactive agents.Type: GrantFiled: August 30, 2001Date of Patent: October 8, 2002Assignee: NitroMed, Inc.Inventors: David S. Garvey, Inigo Saenz de Tejada, Richard A. Earl, Subhash P. Khanapure
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Patent number: 6458823Abstract: This invention concerns the treatment of smooth muscle spasticity or excess muscle contraction such as urge urinary incontinence with a compound of the formula wherein: R1 and R2 are independently straight chain alkyl of 1 to 6 carbon atoms, branched alkyl of 3 to 6 carbons atoms, or cycloalkyl of 3 to 6 carbons atoms where R2 may be substituted by F, Cl, Br, I, OH, NH2, cyano, C1-C6 alkoxy, C1-C6alkylthio, COOH or COOC1-C6 alkyl; R3 is an aryl or heteroaryl as defined herein, optionally substituted with 0 to 4 groups selected independently from C1-C6 alkyl, C1-C6 alkoxy, cyano, F, Cl, Br, C1-C6 alkylthio, CO2R1, CONH2, OH, NH2, and NO2; n is 0 or 1; R4 is a straight chain alkyl group of 1 to 10 carbons atoms, a branched alkyl of 3 to 10 carbons, or a cycloalkyl of 3 to 10 carbons; and all crystalline forms and the pharmaceutically acceptable salts thereof.Type: GrantFiled: September 25, 2001Date of Patent: October 1, 2002Assignee: WyethInventors: Adam Matthew Gilbert, Zhen-jia Chen
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Publication number: 20020137759Abstract: The present invention provides an at least quaternary composition for controlling insects or representatives of the order Acarina and microorganisms, which composition comprises: (A) an insecticidally effective amount of at least one neonicotinoid or phenylpyrazole insecticide, and (B) a fungicidally effective amount of at least three fungicides including: (B1) at least one phenylamide (acylalanine type), (B2) at least one phenylpyrrole and (B3) at least one triazole.Type: ApplicationFiled: March 8, 2002Publication date: September 26, 2002Inventors: Ferdinand Martin Schneidersmann, Marian Ladislav Stypa
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Patent number: 6444696Abstract: The present invention relates to certain pyrazole derivatives of Formula (I): that are p-38 MAP kinase inhibitors, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.Type: GrantFiled: July 19, 2001Date of Patent: September 3, 2002Assignee: Syntex (U.S.A.) LLCInventors: David Michael Goldstein, Sharada Shenvi Labadie, David Mark Rotstein, Eric Brian Sjogren, Francisco Xavier Talamas
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Patent number: 6436915Abstract: Pharmaceutical compositions and compounds are provided. The compounds of the invention have anti-proliferative activity, and may promote apoptosis in cells lacking normal regulation of cell cycle and death. In one embodiment of the invention, formulations of the compounds in combination with a physiologically acceptable carrier are provided. The pharmaceutical formulations are useful in the treatment of hyperproliferative disorders, which disorders include tumor growth, lymphoproliferative diseases, angiogenesis. The compounds of the invention are substituted pyrazoles and pyrazolines.Type: GrantFiled: December 22, 2000Date of Patent: August 20, 2002Assignee: Kinetek Pharmaceuticals, Inc.Inventors: Zaihui Zhang, Timothy Scott Daynard, Shisen Wang, Mikhail Chafeev
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Publication number: 20020111374Abstract: Estrogen receptor-modulating pyrazole compounds are described in addition to methods and compositions for treating or preventing estrogen receptor-mediated disorders. The compounds described have been found to have unexpected and surprising activity in modulating estrogen receptor activity. Thus, the compounds of the present invention have utility in preventing or treating estrogen receptor-mediated disorders such as osteoporosis, breast and endometrial cancers, atherosclerosis, and Alzheimer's disease.Type: ApplicationFiled: September 18, 2001Publication date: August 15, 2002Applicant: Chiron CorporationInventors: Verena D. Huebner, Xiaodong Lin, Ian James, Liya Chen, Manoj Desai, Beata Krywult, Rajinder Singh, Liang Wang
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Patent number: 6432997Abstract: The invention relates to new 1-arylpyrazole hydroxylamines and hydrazines of the formula wherein the structural variables are as defined in the specification. The subject compounds are especially useful as pesticides, for controlling arthropods, especially insects, by systemic action.Type: GrantFiled: September 24, 1999Date of Patent: August 13, 2002Assignee: Rhone-Poulenc, Inc.Inventor: Tai-Teh Wu
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Patent number: 6432998Abstract: The present invention provides an insecticidal composition comprising, as active ingredients, (a) at least one pyrethroid compound and (b) an N-arylpyrazole compound such as 5-amino-3-cyano-1-(2,6-dichloro)-4-trifluoromethylphenyl)-4-trifluoromethylsulfinylpyrazole, and an insecticidal method which comprises applying the composition.Type: GrantFiled: April 6, 2001Date of Patent: August 13, 2002Assignee: Rhone-Poulenc AgrochimieInventors: Hiroshi Kodama, Yasuhiro Wada, Rikio Yamaguchi
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Patent number: 6414010Abstract: Process for the protection of a building that has already been built or is going to be built, whereby an effective amount of an insecticidally active compound is spread around or under the said building at discrete locations. The insecticide may be an arylpyrazole.Type: GrantFiled: July 19, 1999Date of Patent: July 2, 2002Assignee: Rhone-Poulenc AgroInventor: Yasuo Kimura
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Publication number: 20020081327Abstract: The direct pour-on skin solution intended to eliminate parasites, in particular Boophilus microplus, from cattle and sheep comprises from 0.05 to 25%, preferably from 0.05 to 10%, and in particular from 0.Type: ApplicationFiled: November 29, 1999Publication date: June 27, 2002Inventors: JEAN-PIERRE ETCHEGARAY, PHILIPPE JEANNIN
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Patent number: 6407140Abstract: Treatment with a cyclooxygenase-2 inhibitor and a leukotriene A4 hydrolase inhibitor is described as being useful in reducing recipient rejection of transplanted organs and for treatment of autoimmnune diseases.Type: GrantFiled: January 21, 2000Date of Patent: June 18, 2002Assignee: G.D. Searle & Co.Inventors: Susan A Gregory, Peter C Isakson, Gary Anderson
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Patent number: 6403628Abstract: The invention relates to 1-phenylpyrazole derivatives of formula (I): wherein R1, R2, R3, R4 and X are as defined in the description, and to their use as insecticides.Type: GrantFiled: May 26, 2000Date of Patent: June 11, 2002Assignee: Rhone-Poulenc AgroInventors: Jennifer Phillips, Michael Pilato, Tai-Teh Wu
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Patent number: 6376527Abstract: The present invention relates to certain pyrazole derivatives of Formula (I): that are p-38 MAP kinase inhibitors, pharmaceutical compositions containing them, methods for their use, and methods for preparing these compounds.Type: GrantFiled: May 5, 1999Date of Patent: April 23, 2002Assignee: Syntex (U.S.A.) LLCInventors: David Michael Goldstein, Sharada Shenvi Labadie, David Mark Rotstein, Eric Brian Sjogren, Francisco Xavier Talamas
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Publication number: 20020045573Abstract: In accordance with the present invention, there is provided a new class of drugs for therapeutic treatment of such indications as cerebral stroke and other ischemia/reperfusion injury. Thus, in accordance with the present invention, dithiocarbamates are linked to the surface of a non-immunogenic, non-targeting macromolecule other than an antibody (e.g., albumin protein) either by using cross-linking reagents or by nonspecific binding to produce polydithiocarbamate-macromolecule-containing compositions, which represent a new class of drugs for therapeutic treatment of such indications as cerebral stroke and other ischemia/reperfusion injury. In accordance with another aspect of the present invention, combinational therapeutic methods have been developed for the in vivo inactivation or inhibition of formation (either directly or indirectly) of species which induce the expression of inducible nitric oxide synthase, as well as reducing nitric oxide levels produced as a result of .NO synthase expression.Type: ApplicationFiled: October 1, 1999Publication date: April 18, 2002Inventor: CHING-SAN LAI
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Patent number: 6372773Abstract: Disclosed are novel aromatic heterocyclic compounds of the formula(I) wherein Ar1,Ar2,L,Q and X are described herein. The compounds are useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are processes of making such compounds.Type: GrantFiled: August 2, 2001Date of Patent: April 16, 2002Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.Inventor: John R. Regan
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METHOD FOR CONTROLLING A POPULATION OF SOCIAL INSECTS USING 1-ARYLPYRAZOLES OR 1-HETEROARYLPYRAZOLES
Publication number: 20020042439Abstract: A method for controlling a population of social insects such as ants, wasps or cockroaches by administering to a minor fraction of the population an effective amount of a composition that includes a bait and a 1-phenylpyrazole-type compound, particularly 5-amino-3-cyano-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulphinyl]-1H-pyrazole.Type: ApplicationFiled: May 27, 1998Publication date: April 11, 2002Inventor: LOUIS ZANGIACOMI -
Publication number: 20020035138Abstract: Compounds represented by formula (I), 1Type: ApplicationFiled: April 30, 2001Publication date: March 21, 2002Applicant: Southern Research InstituteInventors: Joseph A. Maddry, Eric J. Sorscher
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Patent number: 6358988Abstract: Processes for the antiparasitic control of darkling beetles utilizing 1-arylpyrazole insecticides and for applying said insecticides to animal litter, especially for animal rearing, are described. Also described are mixtures of carbaryl and 1-arylpyrazole insecticides.Type: GrantFiled: April 23, 1999Date of Patent: March 19, 2002Assignee: MerialInventors: Philippe Jeannin, James William Smith, Samuel Perry Yenne
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Patent number: 6358945Abstract: Disclosed are novel aromatic compounds which are useful for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases. Also disclosed are pharmaceutical compositions containing and processes of making such compounds.Type: GrantFiled: February 16, 2000Date of Patent: March 19, 2002Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.Inventors: Steffen Breitfelder, Pier F. Cirillo, Thomas A. Gilmore, Eugene R. Hickey, John R. Proudfoot, John R. Regan, Alan D. Swinamer, Hidenori Takahashi
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Publication number: 20020025978Abstract: A formulation for delivery of phenylbutazone for the treatment of equine ailments is disbursed homogeneately in a powdered carrier agent having a flavoring agent and a coloring agent in an amount of from 5 to 49.9 percent by weight of the formulation.Type: ApplicationFiled: August 3, 2001Publication date: February 28, 2002Inventor: George Green
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Patent number: 6350771Abstract: The invention relates to novel 1-arylpyrazole oxime derivatives, of general formula (I) or (I bis) These compounds are found to be generally safe systemic insecticides for control of arthropod, nematode, helminth or protozoan pests including compositions and derivatives thereof.Type: GrantFiled: December 12, 1997Date of Patent: February 26, 2002Assignee: Rhone-Poulenc, Inc.Inventors: Tai-Teh Wu, Alain Chene, David Treadway Manning, Peter Wyatt Newsome, Nicholas Charles Ray, Jennifer Lantz Phillips, Patrick Doyle Lowder
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Patent number: 6346542Abstract: A composition comprising (S)-5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylsulfinylpyrazole and (R)-5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylsulfinylpyrazole, enantiomerically enriched in the (S)-enantiomer.Type: GrantFiled: April 14, 2000Date of Patent: February 12, 2002Assignee: Aventis CropScience S.A.Inventor: Scot Kevin Huber
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Patent number: RE37936Abstract: A compound of formula (I): compositions containing them and methods of use to control pests.Type: GrantFiled: July 13, 2001Date of Patent: December 10, 2002Assignee: Aventis CropScience USA Inc.Inventors: Jamin Huang, Scot Kevin Huber