Additional Hetero Ring Patents (Class 514/422)
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Patent number: 12121509Abstract: Provided herein are methods of improving kidney function in a subject in need thereof.Type: GrantFiled: July 18, 2023Date of Patent: October 22, 2024Assignee: Chinook Therapeutics, Inc.Inventors: Philip Thomas Frohlich, Andrew James King, Chidambaram Ramachandran, Sarah Beth Noonberg
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Patent number: 12064404Abstract: The present invention provides topical dosages and formulations of lidocaine and pharmaceutically acceptable salts thereof, which are efficacious, chemically stable and physiologically balanced for safety and efficacy, particularly for debridement pain, and increase the duration of pain relief, and thereby provide more effective treatment to chronic open wounds, particularly those in non-mucosal tissue.Type: GrantFiled: September 6, 2022Date of Patent: August 20, 2024Inventors: Hemant H. Alur, James A H Harwick
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Patent number: 11998526Abstract: Provided herein are methods of improving kidney function in a subject in need thereof.Type: GrantFiled: July 18, 2023Date of Patent: June 4, 2024Assignee: CHINOOK THERAPEUTICS, INC.Inventors: Philip Thomas Frohlich, Andrew James King, Chidambaram Ramachandran, Sarah Beth Noonberg
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Patent number: 11883380Abstract: Provided herein are compositions and methods for administration of sulcardine to a subject in need thereof.Type: GrantFiled: May 23, 2022Date of Patent: January 30, 2024Assignee: HUYABIO INTERNATIONAL, LLCInventors: Suzanne J. Romano, Gary T. Elliott
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Patent number: 11833146Abstract: There is provided a therapeutic agent for Alzheimer's disease and Lewy body dementia for combined use of (S)-7-(2-methoxy-3,5-dimethylpyridin-4-yl)-1-(tetrahydrofuran-3-yl)-1H-pyrazolo[4,3-c]quinoline-4(5H)-one represented by formula (1): or a pharmaceutically acceptable salt thereof, and donepezil represented by formula (II): or a pharmaceutically acceptable salt thereof.Type: GrantFiled: May 30, 2018Date of Patent: December 5, 2023Assignee: Eisai R&D Management Co., Ltd.Inventors: Mai Miyamoto, Sadaharu Kotani
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Patent number: 11739082Abstract: The present invention relates to novel thiophene compounds of general Formula I, and their stereoisomers (diastereoisomers, enantiomers), pure or mixed, racemic mixtures, geometrical isomers, tautomers, pharmaceutically acceptable salts, hydrates, solvates, solid forms and mixtures thereof along with process for their preparation. The present invention discloses compounds that are useful in the treatment and prevention of autoimmune diseases.Type: GrantFiled: August 31, 2018Date of Patent: August 29, 2023Assignee: Ahammune Biosciences Private LimitedInventors: Kashinath Komirishetty, Mahesh Kumar Verma, Parul Ganju, Sudhanand Prasad
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Patent number: 11707475Abstract: A composition for treating multiple disease causes including a glycocalyx restoring and maintaining compound. A method of treating multiple disease causes, by administering a glycocalyx restoring and maintaining compound to an individual, restoring the glycocalyx, reversing inflammation, and reversing oxidative damage. A method of treating cardiovascular disease. A method of restoring the glycocalyx. A method of reversing inflammation. A method of reversing oxidative damage. A method of treating any disease involving a membrane that has a glycocalyx. A method of treating multiple disease causes. A method of restoring the structural and functional integrity of receptors in the glycocalyx. A method of restoring the glycocalyx and receptors therein and potentiating drug response. A composition for treating disease including the glycocalyx restoring and maintaining compound and an antibody.Type: GrantFiled: September 4, 2019Date of Patent: July 25, 2023Assignee: Arterez, INC.Inventor: Josefino B. Tunac
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Patent number: 11638698Abstract: A composition including an amphiphilic compound capable of self-assembling into liquid crystalline particles and a statin for systemic administration via oral mucosa. A method of lowering blood cholesterol levels in a subject comprising administering the self-assembling liquid crystalline particles and statin via oral mucosa. Preferred dosage forms result in prolonged release of the statin.Type: GrantFiled: April 20, 2018Date of Patent: May 2, 2023Assignee: Zeenar Enterprises Pty LtdInventors: Gregory Yu Foo Szto, Tomer Madmon, David Kannar
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Patent number: 11591284Abstract: The present invention relates to compounds suitable for treating, ameliorating and/or preventing neuromuscular disorders, including the reversal of drug-induced neuromuscular blockade. The compounds as defined herein preferably inhibit the CIC-1 ion channel. The compounds include phenoxy propanoic acid, phenoxy propanoate, and phenoxy butanoate compounds.Type: GrantFiled: December 14, 2017Date of Patent: February 28, 2023Assignee: NMD PHARMA A/SInventors: Lars J. S. Knutsen, Thomas Holm Pedersen, Claus Elsborg Olesen, Marc A. Labelle, Paul Brian Little, Martin E. Cooper, Neerja Saraswat, Dastagiri Dudekula, Rafiq A. Taj
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Patent number: 11564909Abstract: Liquid oral pilocarpine formulations are described herein. Methods of using the liquid oral pilocarpine formulations are also provided.Type: GrantFiled: November 29, 2021Date of Patent: January 31, 2023Assignee: ROMEG Therapeutics LLCInventors: Indu Muni, Naomi Vishnupad
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Patent number: 11491137Abstract: Provided herein are methods of improving kidney function in a subject in need thereof.Type: GrantFiled: May 27, 2022Date of Patent: November 8, 2022Assignee: Chinook Therapeutics, Inc.Inventors: Philip Thomas Frohlich, Andrew James King, Chidambaram Ramachandran, Sarah Beth Noonberg
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Patent number: 11452709Abstract: The invention provides novel compositions and methods for the treatment of Radiation-Induced Bystander Effects (RIBE), resulting from radiation exposure. In one preferred embodiment the inventions includes novel therapeutic agents, including but not limited to quercetin and quercetin analogs, as well as E64, CA074, CA074Me, that interfere with the activity of Cathepsin B.Type: GrantFiled: July 17, 2018Date of Patent: September 27, 2022Assignees: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE, TSINGHUA UNIVERSITY, CHANG GUNG UNIVERSITYInventors: Ding Xue, Yu Peng, Man Zhang, Lingjun Zheng, Qian Liang, Hanzeng Li, Jau-Song Yu, Jeng-Ting Chen
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Patent number: 11345690Abstract: The present invention relates to processes and intermediates for preparing compounds of formula (IA), wherein R1, R4, R5, R6, and L1 are as defined herein. Compounds of formula (IA) have been found useful as EP4 receptor agonists useful in the treatment of glaucoma, osteoporosis, neuropathic pain, and related disorders.Type: GrantFiled: March 12, 2019Date of Patent: May 31, 2022Assignee: Cayman Chemical Company, Inc.Inventors: Stephen Douglas Barrett, Joseph Michael Colombo, Bradlee David Germain, Andriy Kornilov, James Bernard Kramer, Adam Uzieblo
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Patent number: 11180486Abstract: The present invention discloses novel indolylkojyl compounds of formula 1 The invention also provides a one pot, green chemistry method for preparation of indolylkojyl compounds. The compounds of the present invention are selectively toxic towards human breast cancer cells and inhibit tumor growth as well as lung metastasis. The compounds also potentiate the effect of anticancer drugs.Type: GrantFiled: February 5, 2018Date of Patent: November 23, 2021Assignee: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCHInventors: Debaraj Mukherjee, Anindya Goswami, Deepak Sharma, Debasis Nayak, Shreyans Kumar Jain
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Patent number: 11160789Abstract: The present invention relates to the pyrrolidine substituted with flavone derivatives, represented by the compounds of Formula (I) or a pharmaceutically acceptable salt, a solvate, a stereoisomer or a diastereoisomer thereof for use in the treatment of cancers associated with human papillomavirus. The present invention also relates to the pharmaceutical compositions containing the compounds of Formula (I) for the treatment of cancers associated with human papillomavirus.Type: GrantFiled: April 9, 2020Date of Patent: November 2, 2021Assignee: PIRAMAL ENTERPRISES LIMITEDInventors: Swati Ajay Piramal, Muralidhara Padigaru, Veena R. Agarwal, Gandhali Ashwin Deshpande
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Patent number: 11124479Abstract: The invention relates to compounds and pharmaceutical compositions capable of treating amyloid diseases and other diseases characterized by oligomerization and/or fibrillation of amyloidogenic peptides such as islet amyloid polypeptide (IAPP).Type: GrantFiled: July 13, 2018Date of Patent: September 21, 2021Assignee: NEW YORK UNIVERSITYInventors: Andrew D. Hamilton, Sunil Kumar
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Patent number: 10973801Abstract: The present disclosure is directed to methods of using a capsid assembly inhibitor for the treatment of hepatitis B virus infection.Type: GrantFiled: March 13, 2019Date of Patent: April 13, 2021Assignee: Janssen Sciences Ireland Unlimited CompanyInventors: Koen Vandyck, Oliver Lenz, Claire Elisabeth Balmain, Jan Snoeys, Joris Jozef Vandenbossche, Dominique Josiane W. Verstraete, Jeysen Zivan Yogaratnam, Maria Jansens, Frederic Van Dycke
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Patent number: 10888544Abstract: Methods for treating Gaucher disease in patients with renal or hepatic impairment.Type: GrantFiled: December 13, 2018Date of Patent: January 12, 2021Assignee: GENZYME CORPORATIONInventors: Jing Li, M. Judith Peterschmitt, Vanaja Kanamaluru, Jun Chen, Sebastiaan J. M. Gaemers, Dan Rudin
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Patent number: 10752616Abstract: The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain bicycloheteroaryl-heteroaryl-benzoic acid compounds of the following formula (for convenience, collectively referred to herein as “BHBA compounds”), which, inter alia, are (selective) retinoic acid receptor beta (RAR?) (e.g., RAR?2) agonists. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to (selectively) activate RAR? (e.g., RAR?2), to cause or promote neurite development, neurite outgrowth, and/or neurite regeneration, and in the treatment of diseases and conditions that are mediated by RAR? (e.g., RAR?2), that are ameliorated by the activation of RAR? (e.g., RAR?2), etc., including, e.g., neurological injuries such as spinal cord injuries.Type: GrantFiled: August 9, 2019Date of Patent: August 25, 2020Assignee: King's College LondonInventors: Alan David Borthwick, Mark Trevor Mills, Jane Theresa Brown, Jonathan Patrick Thomas Corcoran, Maria Beatriz De Castro Vasconcelos Goncalves, Sarkis Barret Kalindjian
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Patent number: 10688079Abstract: The present invention relates to the pyrrolidine substituted with flavone derivatives, represented by the compounds of Formula (I) or a pharmaceutically acceptable salt, a solvate, a stereoisomer or a diastereoisomer thereof for use in the treatment of cancers associated with human papillomavirus. The present invention also relates to the pharmaceutical compositions containing the compounds of Formula (I) for the treatment of cancers associated with human papillomavirus.Type: GrantFiled: September 7, 2018Date of Patent: June 23, 2020Assignee: Piramal Enterprises LimitedInventors: Swati Ajay Piramal, Muralidhara Padigaru, Veena R. Agarwal, Gandhali Ashwin Deshpande
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Patent number: 10662153Abstract: Thin molecules, compounds producible by cleaving bilirubin at its methylene site in the center of the molecule, methods of making the same, and methods of using the same, are described.Type: GrantFiled: February 27, 2017Date of Patent: May 26, 2020Assignee: The University of ToledoInventors: Terry D. Hinds, Jr., David E. Stec, Christopher J. Trabbic
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Patent number: 10550225Abstract: [Problem] To provide a gel which can be produced in a short time, has controlled properties such as modulus and expansion pressure, and has a low polymer concentration. [Solution] A process for producing a polymer gel in which gel-precursor clusters have been crosslinked with one another to form a three-dimensional network structure, characterized by comprising a) a step in which monomer or polymer units that are present in a concentration less than a critical gelation concentration are crosslinked to form the gel-precursor clusters, the gel-precursor clusters having a storage modulus G? and a loss modulus G? which satisfy the relationship G?<G?, and b) a step in which the gel-precursor clusters are crosslinked with one another by a crosslinking agent to obtain a gel having a three-dimensional network structure.Type: GrantFiled: March 3, 2016Date of Patent: February 4, 2020Assignee: The University of TokyoInventors: Takamasa Sakai, Yuichi Tei
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Patent number: 10500188Abstract: The present invention discloses use of a polyenylpyrrole derivative in preparation of an anti-oral cancer drugs. The polyenylpyrrole derivative synthesized by polyvinylpyrrole, auxarconjugatin A and 12E-isorumbrin inhibits the cell proliferation, migration, tumor sphere formation abilities and xenograft tumorigenicity of oral cancer cells.Type: GrantFiled: April 16, 2019Date of Patent: December 10, 2019Assignee: Tzu Chi UniversityInventors: Jeng-Woei Lee, Chia-Chen Lau, Kuo-Feng Hua, Yulin Lam
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Patent number: 10441574Abstract: The present invention generally relates to a method of treating or preventing an endoplasmic reticulum stress disorder in subjects, such as a method of treating or preventing Wolfram syndrome.Type: GrantFiled: November 13, 2015Date of Patent: October 15, 2019Assignee: Washington UniversityInventors: Fumihiko Urano, Simin Lu
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Patent number: 10413542Abstract: Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.Type: GrantFiled: April 11, 2018Date of Patent: September 17, 2019Assignees: Buck Institute for Research on Aging, Unity Biotechnology, Inc., Mayo Foundation for Medical Education and ResearchInventors: Remi-Martin Laberge, Nathaniel David, Alain Philippe Vasserot, Darren J. Baker, Bennett G. Childs, James L. Kirkland, Tamar Tchkonia, Jan M. A. van Deursen, Yi Zhu
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Patent number: 10413543Abstract: A stable multi-particulate pharmaceutical composition comprising pellets, the pellets comprising a mixture of rosuvastatin or its pharmaceutically acceptable salts as a sole active ingredient, one or more osmotic release modifiers and one or more stabilizers.Type: GrantFiled: February 12, 2016Date of Patent: September 17, 2019Assignee: SUN PHARMA ADVANCED RESEARCH COMPANY LTD.Inventors: Nitin Bhalachandra Dharmadikari, Yashoraj Zala, Ashwini Gadkari
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Patent number: 10385042Abstract: This invention relates to novel inhibitors of UDP-glucose: N-acyl-sphingosine glucosyltransferase and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering inhibitors of UDP-glucose: N-acyl-sphingosine glucosyltransferase.Type: GrantFiled: September 11, 2017Date of Patent: August 20, 2019Assignee: Concert Pharmaceuticals, Inc.Inventor: Scott L. Harbeson
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Patent number: 10385044Abstract: The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain bicycloheteroaryl-heteroaryl-benzoic acid compounds of the following formula (for convenience, collectively referred to herein as “BHBA compounds”), which, inter alia, are (selective) retinoic acid receptor beta (RAR?) (e.g., RAR?2) agonists. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to (selectively) activate RAR? (e.g., RARP?2), to cause or promote neurite development, neurite outgrowth, and/or neurite regeneration, and in the treatment of diseases and conditions that are mediated by RAR? (e.g., RAR?2), that are ameliorated by the activation of RAR? (e.g., RAR?2), etc., including, e.g., neurological injuries such as spinal cord injuries.Type: GrantFiled: June 5, 2018Date of Patent: August 20, 2019Assignee: King's College LondonInventors: Alan David Borthwick, Mark Trevor Mills, Jane Theresa Brown, Jonathan Patrick Thomas Corcoran, Maria Beatriz De Castro Vasconcelos Goncalves, Sarkis Barret Kalindjian
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Patent number: 10385017Abstract: The present invention relates to compositions comprising saroglitazar magnesium wherein the saroglitazar magnesium has a purity of greater than or equal to 99% by weight, and dimer compound of Formula (IV) present in an amount relative to saroglitazar magnesium less than about 0.3% by weight by area percentage of HPLC. The present invention also related to the process for the preparation thereof and pharmaceutical compositions comprising the same.Type: GrantFiled: October 13, 2016Date of Patent: August 20, 2019Assignee: Cadila Healthcare LimitedInventors: Sanjay Jagdish Desai, Ramesh Chandra Singh, Daya Ram Pal, Dharmendra Arvindbhai Darji
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Patent number: 10369145Abstract: Coumarin derivative compounds and methods for the treatment of hyperproliferative diseases, such as cancer, polycystic kidney disease, and fibrosis of different tissues (e.g., idiopathic pulmonary fibrosis), are provided. The methods include administering to a subject a compound as described herein. Also provided are methods for inhibiting the interaction between two or more heat shock protein chaperones in a cell.Type: GrantFiled: March 14, 2014Date of Patent: August 6, 2019Assignee: DISCOVERYBIOMED, INC.Inventors: Erik Schwiebert, John Streiff, John Dixon, Hongwu Gao, Joseph P. Ritchie, Eric C. Seales, Deborah Mai
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Patent number: 10328051Abstract: A pharmaceutical compositions including proline or proline derivatives is provided. A method for the treatment of dementia, Alzheimer's and neurodegenerative diseases with the compositions is also provided.Type: GrantFiled: September 22, 2015Date of Patent: June 25, 2019Inventor: Zoser B. Salama
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Patent number: 10227323Abstract: Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions associated with the enzyme glucosylceramide synthase (GCS).Type: GrantFiled: September 19, 2014Date of Patent: March 12, 2019Assignee: BIOMARIN PHARMACEUTICAL INC.Inventors: Bing Wang, Daniel Chu, Alexander James Bridges
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Patent number: 10227312Abstract: Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions associated with the enzyme glucosylceramide synthase (GCS).Type: GrantFiled: March 10, 2016Date of Patent: March 12, 2019Assignee: BIOMARIN PHARMACEUTICAL INC.Inventor: Bing Wang
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Patent number: 10188606Abstract: This disclosure relates to polymersomes comprising a crosslinked polymer and their use as drug delivery vehicles. Specifically, polymersomes comprising a polymer of Formula I: wherein each R is independently C1-6 alkyl; and n is an integer between 1 and 50.Type: GrantFiled: October 9, 2017Date of Patent: January 29, 2019Assignee: Mayo Foundation for Medical Education and ResearchInventors: Xifeng Liu, Michael J. Yaszemski, Lichun Lu
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Patent number: 10125097Abstract: The present invention relates to 1-[1-(benzoyl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carbonitrile derivatives having pharmacological activity to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy and/or prophylaxis of a cognitive disorder.Type: GrantFiled: November 11, 2013Date of Patent: November 13, 2018Assignees: UNIVERSITAT DE BARCELONA, FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA), IPROTEOS S.L.Inventors: Ernest Giralt Lledó, Teresa Tarragó Clua, Roger Prades Cosano, Soledad Royo Gracia
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Patent number: 10098869Abstract: The present invention relates to the pyrrolidine substituted with flavone derivatives, represented by the compounds of Formula (I) or a pharmaceutically acceptable salt, a solvate, a stereoisomer or a diastereoisomer thereof for use in the treatment of cancers associated with human papillomavirus. The present invention also relates to the pharmaceutical compositions containing the compounds of Formula (I) for the treatment of cancers associated with human papillomavirus.Type: GrantFiled: August 8, 2016Date of Patent: October 16, 2018Assignee: PIRAMAL ENTERPRISES LIMITEDInventors: Swati Ajay Piramal, Muralidhara Padigaru, Veena R. Agarwal, Gandhali Ashwin Deshpande
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Patent number: 10086071Abstract: Methods are provided for treating a subject for at least one condition that includes inflammation, a blood clotting condition and autonomic nervous system dysfunction such as adrenergia, e.g., simultaneously. Also provided are kits for use in practicing the subject methods.Type: GrantFiled: September 24, 2013Date of Patent: October 2, 2018Assignee: Palo Alto InvestorsInventors: Anthony Joonkyoo Yun, Patrick Yuarn-Bor Lee
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Patent number: 10028918Abstract: Nanoparticles are provided that comprise S-nitrosothiol (SNO) groups covalently bonded to the nanoparticles and/or S-nitrosothiol containing molecules encapsulated within the nanoparticles, as well as methods of making and using the nanoparticles. The invention also provides methods of preparing nanoparticles comprising Snitrosothiol (SNO) groups covalently bonded to the nanoparticles, where the methods comprise a) providing a buffer solution comprising chitosan, polyethylene glycol, nitrite, glucose, and hydrolyzed 3-mercaptopropyltrimethoxysilane (MPTS); b) adding hydrolyzed tetramethoxysilane (TMOS) to the buffer solution to produce a sol-gel; and c) lyophilizing and ball milling the sol-gel to produce nanoparticles of a desired size.Type: GrantFiled: May 1, 2013Date of Patent: July 24, 2018Assignees: Albert Einstein College of Medicine, Inc., La Jolla Bioengineering InstituteInventors: Parimala Nacharaju, Adam J. Friedman, Joel M. Friedman
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Patent number: 9994542Abstract: The invention provides compounds of formula (I) or salts thereof: wherein: A, B, C, D, W, X, Y and Z are as defined in the specification, and at least one of A, B, C, D, W, X, Y and Z is OR1; each R1 being independently H or C(?O)R2, and at least one R1 group being C(?O)R2; where each R2 is selected from: CHR3NHR4, where R4 is H and R3 is a group selected from CH3, CH2CH(CH3)2, CH(CH3)CH2CH3, CH2Ph, CH2-3-(1H-indole), CH2CH2SCH3, CH2OH, CHOHCH3, CH2SH, CH2SeH and CH2PhpOH, wherein said R3 group can optionally be substituted by one or more groups selected from halogen, cyano, nitro, ORA or C1-C4 alkyl; or R3 and R4 together with the C and N atoms to which they are attached form a 5-membered heteroalkyl ring, wherein said heteroalkyl ring can optionally be substituted by one or more groups selected from halogen, cyano, nitro, ORA or C1-C3 alkyl, wherein RA is C1-C4 alkyl optionally substituted with one or more halogen, cyano or nitro groups.Type: GrantFiled: December 23, 2014Date of Patent: June 12, 2018Assignee: Amazentis SAInventors: Christopher Lawrence Rinsch, Rune Andreas Ringom
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Patent number: 9988376Abstract: A compound of formula (I): or a pharmaceutically acceptable salt thereof, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, for example as inhibitors of the activity of the estrogen receptor, including degrading the estrogen receptor, the treatment of diseases and conditions mediated by the estrogen receptor.Type: GrantFiled: July 1, 2014Date of Patent: June 5, 2018Assignee: GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITEDInventors: Sebastien Andre Campos, John David Harling, Afjal Hussain Miah, Ian Edward David Smith
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Patent number: 9981018Abstract: A method of promoting hair growth of a subject includes administering to follicle cells of the subject a therapeutically effective amount of a TLR2 agonist that promotes TLR2 activation and hair growth of the subject.Type: GrantFiled: December 10, 2012Date of Patent: May 29, 2018Assignee: The Cleveland Clinic FoundationInventor: Tatiana Byzova
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Patent number: 9956260Abstract: Provided herein are compositions and methods for the treatment of a patient having an HIV-1 infection and/or AIDS. More specifically this invention provides treatment of an HIV-1 infection and/or AIDS using small molecule compounds, such as inhibitors for the activation and/or activity of caspase-1. Inhibitors for the activation and/or activity of caspase-1 also prevent the cell death of CD4 T-cells in a population of CD4 T-cells comprising HIV-1 infected CD4 T-cells and uninfected CD4 T-cells, In addition, caspase-1 inhibitors inhibit inflammation, and pyroptosis.Type: GrantFiled: July 23, 2012Date of Patent: May 1, 2018Assignee: The J. David Gladstone InstitutesInventors: Warner C. Greene, Gilad Doitsh, Orlando Zepeda, Nicole Galloway
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Patent number: 9815824Abstract: Provided are compounds of Formula I; and pharmaceutically acceptable salts and solvates thereof. The present disclosure relates to novel compounds and to their use as agonists of the kappa opioid receptor. The disclosure also relates to methods for preparation of the compounds and to pharmaceutical compositions containing such compounds. Kappa opioid agonists that exhibit full agonist properties at the kappa opioid receptor have been widely shown to be efficacious in preclinical models of pain, particularly visceral pain.Type: GrantFiled: June 27, 2014Date of Patent: November 14, 2017Assignee: Nektar TherapeuticsInventors: Neel K. Anand, Franco J. Duarte, Wen Zhang, Zhongxu Ren
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Patent number: 9783528Abstract: This invention relates to novel inhibitors of UDP-glucose: N-acyl-sphingosine glucosyltransferase and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering inhibitors of UDP-glucose: N-acyl-sphingosine glucosyltransferase.Type: GrantFiled: September 14, 2015Date of Patent: October 10, 2017Assignee: Concert Pharmaceuticals, Inc.Inventor: Scott L. Harbeson
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Patent number: 9701630Abstract: Disclosed herein are compositions and methods of treating osteroporosis, bone fracture, bone loss, and increasing bone density by administration of compounds of formula (I) or compositions comprising a compound of formula (I) and a pharmaceutically acceptable carrier, wherein L1, L2, L4, R1, R4, R5, R6, and s are as defined in the specification.Type: GrantFiled: August 2, 2016Date of Patent: July 11, 2017Assignees: Cayman Chemical Company, Inc., Myometrics, LLCInventors: Stephen Douglas Barrett, Fred Lawrence Ciske, Joseph Michael Colombo, Gregory William Endres, Bradlee David Germain, Andriy Kornilov, James Bernard Kramer, Adam Uzieblo, Thomas Allen Owen, James Paul O'Malley
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Patent number: 9693988Abstract: An aqueous formulation for topical application to the skin comprising water, a water-miscible organic solvent, and benzoyl peroxide, wherein the concentration of the organic solvent is sufficient to provide a stable suspension of benzoyl peroxide in the aqueous formulation without the inclusion of a surfactant in the formulation, wherein the ratio of concentrations of water and organic solvent in the formulation is sufficient to maintain the benzoyl peroxide in saturated solubility in the formulation following, application to the skin, and wherein the concentration of benzoyl peroxide in the formulation is less than 5.0% and at least 1.0% w/w. The formulation may further contain a chemical compound in addition to benzoyl peroxide that is effective in the treatment of acne. The aqueous formulations of the invention are useful in the treatment of acne and acne rosacea.Type: GrantFiled: September 13, 2012Date of Patent: July 4, 2017Assignee: DOW PHARMACEUTICAL SCIENCES, INC.Inventors: Yunik Chang, Gordon J. Dow
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Patent number: 9671688Abstract: Disclosed are a monomer represented by the following Chemical Formula 1 for a hardmask composition, a hardmask composition including the monomer, and a method of forming patterns using the same. In the above Chemical Formula 1, A, A?, L, L?, X and n are the same as defined in the specification.Type: GrantFiled: October 2, 2013Date of Patent: June 6, 2017Assignee: Cheil Industries, Inc.Inventors: Seung-Wook Shin, Yun-Jun Kim, Hea-Jung Kim, Youn-Jin Cho, Yoo-Jeong Choi
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Patent number: 9637476Abstract: The present disclosure relates to: (a) mandelate salts of atrasentan, (b) pharmaceutical compositions comprising an atrasentan mandelate salt, and, optionally, one or more additional therapeutic agents; (b) methods of using an atrasentan mandelate salt to treat nephropathy, chronic kidney disease, and/or other conditions; (c) kits comprising a first pharmaceutical composition comprising an atrasentan mandelate salt, and, optionally, a second pharmaceutical composition comprising one or more additional therapeutic agents; (d) methods for the preparation of an atrasentan mandelate salt; and (e) atrasentan mandelate salts prepared by such method.Type: GrantFiled: January 12, 2015Date of Patent: May 2, 2017Assignee: AbbVie Inc.Inventors: Yuchuan Gong, Geoff G. Zhang
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Patent number: 9556155Abstract: The disclosure provides methods for treating fatty liver disease and associated conditions by inhibiting the synthesis of glucosphingolipids, as exemplified by the use of glucosylceramide synthase substrate analogs.Type: GrantFiled: April 8, 2014Date of Patent: January 31, 2017Assignee: Genzyme CorporationInventors: Hongmei Zhao, Nelson S. Yew, Seng H. Cheng, Canwen Jiang, Cynthia Marie Arbeeny
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Patent number: 9532976Abstract: The invention provides methods of treating a diabetic subject comprising administering a glucosylceramide synthase inhibitor to the subject.Type: GrantFiled: August 20, 2014Date of Patent: January 3, 2017Assignee: Genzyme CorporationInventors: Seng H. Cheng, Nelson S. Yew, Ronald K. Scheule, Hongmei Zhao