Nitrogen Bonded Directly To The Five-membered Hetero Ring By Nonionic Bonding Patents (Class 514/426)
  • Patent number: 4567190
    Abstract: Substituted phenylhydrazonopyrrolidine derivatives of the formula ##STR1## wherein R is halogen or C.sub.1 -C.sub.4 -alkyl,n is zero, 1 or 2, andR* is the group --CH.dbd.N--R.sub.1 or ##STR2## in which R.sub.1 is a pyridine group which is bound by way of a carbon atom, and which is unsubstituted or substituted by a methyl group, or is a 2-thiazolyl group, andR.sub.2 is methyl or ethyl,R.sub.3 is C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.2 -alkoxy or C.sub.1 -C.sub.4 -alkylthio, andX is oxygen or sulfur,have valuable properties for controlling pests, such as phytoparasitic and zooparasitic insects and acarids, including in particular ectoparasites.
    Type: Grant
    Filed: June 21, 1984
    Date of Patent: January 28, 1986
    Assignee: Ciba-Geigy Corporation
    Inventors: Jean-Claude Gehret, Walter Traber
  • Patent number: 4559357
    Abstract: Compounds of the formula ##STR1## and of the isomeric formulae ##STR2## wherein R is alkyl or halogen, R.sub.1 is hydrogen, optionally substituted alkyl or optionally substituted alkenyl, R.sub.2 is hydrogen or methyl, R.sub.3 is hydrogen, alkyl or alkenyl, and X is oxygen or sulfur, including their acid salts, are insecticidally and acaricidally active.
    Type: Grant
    Filed: June 6, 1983
    Date of Patent: December 17, 1985
    Assignee: Ciba-Geigy Corporation
    Inventors: Jean-Claude Gehret, Walter Traber
  • Patent number: 4556674
    Abstract: This invention relates to therapeutically useful compounds, particularly in the cardiovascular field, having the formula: ##STR1##
    Type: Grant
    Filed: January 17, 1984
    Date of Patent: December 3, 1985
    Assignee: Laboratoires Jacques Logeais
    Inventors: Jacques G. Maillard, Tri V. Van, Jacky M. Legeai, Marguerite M. Benharkate
  • Patent number: 4548928
    Abstract: Compounds of the structure: ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, and R.sub.6 are hydrogen, alkyl, alkenyl, alkynyl, phenyl-alkyl, or cycloalkyl,n is an integer from 0 to 4 inclusive,M is heterocyclic or heterocyclic alkyl,Y is hydroxy, alkoxy, amino, or substituted amino, amino-alkanoyl, aryloxy, aminoalkoxy, or hydroxyalkoxy, andR.sub.7 is hydrogen, alkanoyl, carboxylalkanoyl, hydroxyalkanoyl, amino-alkanoyl, cyano, amidino, carbalkoxy, ##STR2## wherein Z is hydrogen, alkyl, hydroxyalkyl, aminoalkyl or the radical ##STR3## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, n, M and Y are as described above; and where Y is hydroxy their nontoxic, pharmaceutically acceptable alkali metal, alkaline earth metal, and amine salts.
    Type: Grant
    Filed: November 19, 1984
    Date of Patent: October 22, 1985
    Assignee: USV Pharmaceutical Co.
    Inventors: John T. Suh, Jerry W. Skiles, Bruce E. Williams, Alfred Schwab
  • Patent number: 4544654
    Abstract: Novel substituted sulfonamidobenzamides are described as useful antiarrhythmic agents. Their use in the treatment of cardiac arrhythmias, especially re-entrant arrhythmias, via the prolongation of the action potential of cardiac tissue is provided. Pharmaceutical formulations containing such compounds are also disclosed.
    Type: Grant
    Filed: March 20, 1984
    Date of Patent: October 1, 1985
    Assignee: Schering A.G.
    Inventors: David D. Davey, William C. Lumma, Jr., Ronald A. Wohl
  • Patent number: 4535087
    Abstract: The N-substituted phenoxyacetamides of this invention are effective fungicides. In particular, these compounds are particularly effective against Tomato Late Blight.
    Type: Grant
    Filed: November 19, 1982
    Date of Patent: August 13, 1985
    Assignee: Chevron Research Company
    Inventor: David M. Spatz
  • Patent number: 4510139
    Abstract: Novel 2-(hydroxyphenylamino)benzamides and oxidation products thereof, useful as inhibitors of lipoxygenase, are of the formulas ##STR1## wherein R is hydrogen, lower-alkyl, halo or lower-alkoxy; R' is hydrogen or lower-alkyl; R" is hydrogen, lower-alkyl or halo; and N.dbd.Z is amino or substituted amino. The compounds of Formula I are prepared by de-etherification of the corresponding alkyl or benzyl ethers; and the compounds of Formula II are prepared by oxidation of the compounds of Formula I where R' is hydrogen and OH is in the 4-position.
    Type: Grant
    Filed: January 6, 1984
    Date of Patent: April 9, 1985
    Assignee: Sterling Drug Inc.
    Inventor: Denis M. Bailey
  • Patent number: 4507291
    Abstract: This invention relates to a method of using compounds of the formula: ##STR1## wherein R.sup.1 is hydrogen, alkyl or alkenyl; R.sup.2 is hydrogen, alkyl, cycloalkyl or mononuclear aryl or R.sup.1 and R.sup.2, taken together with the carbon atom to which they are attached, form a cycloalkyl or cycloalkoxyalkyl; R.sup.3 is hydroxy, alkyl, alkoxycarbonyl, hydroxy lower alkyl or a radical of the formula: --C(.dbd.Y)NR.sup.4 R.sup.5 wherein R.sup.4 is hydrogen, alkyl, alkenyl, R.sup.5 is alkyl, alkenyl, alkoxyalkyl, carbalkoxy, mononuclear aryl, or R.sup.4 and R.sup.5 may be joined together with the nitrogen atom to which they are attached to form a 5 to 7 membered heterocyclic ring having from 1 to 3 hetero atoms; Y is O or S; X is alkyl, alkoxycarbonylalkyl or cyano; m is an integer of 0 to 2 and n and n' are integers each having a value of 1 to 2 and the dotted line indicates an optional double bond anywhere in the ring, compositions containing said compounds as insect repellents and to novel compounds.
    Type: Grant
    Filed: July 15, 1982
    Date of Patent: March 26, 1985
    Assignee: Rohm and Haas Company
    Inventor: Joel R. Smolanoff