Two Double Bonds Between Ring Members Of The Five-membered Hetero Ring (e.g., Pyrrole, Etc.) Patents (Class 514/427)
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Patent number: 6337345Abstract: The invention relates to an insecticidal and miticidal composition which contains as active ingredients 4-bromo-2-(4-chlorophenyl)-1-(ethoxymethy)-5-(trifluoromethyl)pyrrole-3-carbonitrile in combination with one or more compounds selected from the group consisting of formamidine-type insecticidal and miticidal agents, organosulfur-type insecticidal and miticidal agents, thiocarbamate-type insecticidal and miticidal agents, phenisobromolate, pyrimidifen, milbemectin and dinitromethylheptylphenyl crotonate. The insecticidal and miticidal composition of the invention is effective against pests and mites having resistance to commercial insecticidal and miticidal agents.Type: GrantFiled: May 24, 1999Date of Patent: January 8, 2002Assignee: American Cyanamid Co.Inventor: Toshiki Fukuchi
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Patent number: 6329419Abstract: This invention relates to an insecticidal and miticidal composition which contains as active ingredients chlorfenapyr [4-bromo-2-(chlorophenyl)-1-(ethoxymethyl)-5-(trifluoromethyl)pyrrole-3-carbonitrile] in combination with asynergistic amount of at least one of a carbamate-type insecticidal compound.Type: GrantFiled: June 1, 1999Date of Patent: December 11, 2001Assignee: American Cyanamid Co.Inventor: Toshiki Fukuchi
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Patent number: 6319939Abstract: The present invention is concerned with compounds of formula the N-oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein X represents O, S or NR3; R1 represents hydrogen, hydroxy, C1-6alkyl or aryl; R2 represents hydrogen; optionally substituted C1-12alkyl; C3-7cycloalkyl; C2-8alkenyl; aryl; Het1; or R1 and R2 taken together may form a bivalent radical of formula —(CH2)n— wherein n is 2, 3, 4, 5 or 6; R3 represents hydrogen, optionally substituted C1-6alkyl, aryl, Het1; R4 represents hydrogen; hydroxy; mercapto; C1-6alkyloxy; C1-6alkylthio; aryloxy; arylthio; Het1-oxy; Het1-thio; optionally substituted C1-12alkyl; optionally substituted C2-8alkenyl; optionally substituted C2-8alkynyl; optionally substituted C3-7cycloalkyl; optionally substituted C5-7cycloalkenyl; aryl; Het1; or -Alk-NR3R5 (i) or —NR3R5 (ii) wherein Alk represents C1-6alkanediyl; and R5 represents hydrogen, C1-6alkyl, aryl, Het1, (aryl or Het1)C1-6alkType: GrantFiled: June 1, 2000Date of Patent: November 20, 2001Assignee: Janssen Pharmaceutica N.V.Inventors: Dominique Mabire, Christophe Denis Adelinet, Imré Christian Csoka, Marc Gaston Venet
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Patent number: 6316430Abstract: The invention relates to an insecticidal and miticidal composition which contains as active ingredients chlorfenapyr in combination with one or more organophosphoric acid ester-type compounds and to a method for controlling insecticidal or miticidal pests which have acquired resistance to commercial insecticidal and miticidal agents.Type: GrantFiled: June 1, 1999Date of Patent: November 13, 2001Assignee: American Cyanamid Co.Inventor: Toshiki Fukuchi
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Patent number: 6316459Abstract: O-Benzyloxime ethers of the formula I where X is substituted or unsubstituted CH2, NOalkyl Y is O, S, NR5 R1, R2, R5 are H, alkyl Z1, Z2 are H, halogen, methyl, methoxy, cyano R3, R4 are hydrogen, cyano, substituted or unsubstituted alkyl, alkenyl, cycloalkyl, cycloalkenyl, alkynyl, alkoxy, haloalkoxy, alkylthio, benzylthio, alkylcarbonyl, substituted or unsubstituted phenylcarbonyl, substituted or unsubstituted benzylcarbonyl, alkoxycarbonyl, substituted or unsubstituted phenoxycarbonyl, substituted or unsubstituted benzyloxycarbonyl, N(R6)2, where R6 is H, alkyl, substituted or unsubstituted phenyl, —CO—N(R7)2, where R7 is H, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted aryloxy, substituted or unsubstituted arylthio, substituted or unsubstituted hetaryl, substituted or unsubstituted hetaryloxy, substituted or unsubstituted hetarylthio, substituted or unsubstituted heterocyclyl, substituted or unsubstituted heterocyType: GrantFiled: October 25, 1994Date of Patent: November 13, 2001Inventors: Siegbert Brand, Uwe Kardorff, Reinhard Kirstgen, Bernd Mueller, Klaus Oberdorf, Hubert Sauter, Gisela Lorenz, Eberhard Ammermann, Christoph Kuenast, Albrecht Harreus
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Patent number: 6316480Abstract: A fungicidal mixture, comprising a) a carbamate of the formula I, where T is CH or N, n is 0, 1 or 2 and R is halogen, C1-C4-alkyl or C1-C4-haloalkyl, it being possible for the radicals R to be different if n is 2, and b) at least one compound of the formula II or III, in a synergistically effective amount.Type: GrantFiled: November 17, 1999Date of Patent: November 13, 2001Assignee: BASF AktiengesellschaftInventors: Klaus Schelberger, Maria Scherer, Hubert Sauter, Bernd Müller, Erich Birner, Joachim Leyendecker, Eberhard Ammermann, Gisela Lorenz, Siegfried Strathmann
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Publication number: 20010029263Abstract: This invention relates to methods of treating hair loss, through hair revitalization and germination, by administering non-immunosuppresive pyrrolidine carboxylate compounds.Type: ApplicationFiled: April 5, 2001Publication date: October 11, 2001Applicant: GPI NIL Holdings, Inc.Inventors: Joseph P. Steiner, Gregory S. Hamilton
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Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use
Patent number: 6297260Abstract: The present invention describes novel nitrosated and/or nitrosylated nonsteroidal antiinflammatory compounds, and novel compositions comprising at least one nitrosated and/or nitrosylated nonsteroidal antiinflammatory compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase. The present invention also provides methods for treating, preventing and/or reducing inflammation, pain, and fever; decreasing or reversing the gastrointestinal, renal and other toxicities resulting from the use of nonsteroidal antiinflammatory drugs; treating and/or preventing gastrointestinal disorders; treating inflammatory disease states and disorders; and treating and/or preventing ophthalmic diseases or disorders.Type: GrantFiled: October 29, 1999Date of Patent: October 2, 2001Assignee: NitroMed, Inc.Inventors: Upul K. Bandarage, Qing Dong, Xinqin Fang, David S. Garvey, Gregory J. Mercer, Stewart K. Richardson, Joseph D. Schroeder, Tiansheng Wang -
Patent number: 6297263Abstract: Compositions which contain compounds of the general formula (I) wherein X represents═CH— or ═N—, E represents an electron-withdrawing radical, R represents optionally substituted hetarylalkyl, A represents hydrogen, alkyl, or a bifunctional group which is linked to the radical Z, Z represents alkyl, —NH—alkyl, —N(alkyl)2 or a bifunctional group which is linked to the radical A, in mixtures with fungicidal active compounds, excluding cyclopropylcarboxamide derivatives and azolylmethylcycloalkanes. These compositions are useful to control fungi and insects.Type: GrantFiled: June 1, 2000Date of Patent: October 2, 2001Assignee: Bayer AktiengesellschaftInventors: Stefan Dutzmann, Christoph Erdelen, Wolfram Andersch, Heinz-Wilhelm Dehne, Jürgen Hartwig, Klaus Stenzel, Wolfgang Krämer
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Patent number: 6294568Abstract: The present invention provides compounds represented by the general formula (I): and a salt thereof, and anti-inflammatory agents and antitumor agents containing the compounds as the active ingredients.Type: GrantFiled: June 26, 2000Date of Patent: September 25, 2001Assignee: Nissin Food Products Co., Ltd.Inventors: Toshihiro Yamada, Yoichi Nobuhara, Kazuhiro Kobayashi, Satoshi Hirano, Takanobu Sakurai, Hiroshi Mikami, Ayako Miyake
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Publication number: 20010020035Abstract: Disclosed are compounds of the formula 1Type: ApplicationFiled: June 1, 1998Publication date: September 6, 2001Inventors: PAMELA ALBAUGH, GANG LIU, ALAN HUTCHISON
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Publication number: 20010020013Abstract: This invention relates to compounds, pharmaceutical compositions, and methods of using compounds of the formula; 1Type: ApplicationFiled: December 26, 2000Publication date: September 6, 2001Applicant: GUILFORD PHARMACEUTICALS, INC.Inventors: Jie Zhang, Larisa E. Serdyuk, Jia-He Li
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Patent number: 6277833Abstract: Substituted triols are prepared by reducing appropriately substituted carboxylic esters. The substituted triols can be used as active substances in medicaments.Type: GrantFiled: September 24, 1998Date of Patent: August 21, 2001Assignee: Bayer AktiengesellschaftInventors: Rolf Angerbauer, Peter Fey, Walter Hübsch, Thomas Philipps, Hilmar Bischoff, Hans-Peter Krause, Jörg Petersen von Gehr, Delf Schmidt
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Patent number: 6277849Abstract: The invention relates to novel pesticidally active compounds of the general formula I as well as possible isomers and isomeric mixtures thereof, wherein n is a number zero or one; and R1 is C1-C12alkyl that is unsubstituted or may be substituted by C1-C4alkoxy, C1-C4alkylthio, C1-C4alkylsulfonyl, C3-C8acycloalkyl, cyano, C1-C6alkoxycarbonyl, C3-C8alkenyloxycarbonyl, C1-C5alkynyloxycarbonyl; C3-C8cycloalkyl; C2-C12alkenyl: C2-C12alknyl; C1-C12haloalkyl or a group NR11R12; wherein R11, and R12 are each independently of the other hydrogen, C1-C6alkyl or together are tetra- or penta-methylene; R2 and R3 are each independently of the other hydrogen; C1-C8alkyl; C1-C8alkyl substituted by hydroxy, C1-C4alkoxy, mercapto or by C1C4alkylthio; C3-C8alkenyl; C3-C8alkynyl; C3-C8cycloalkyl; C3-C8acycloalkyl-C1-C4alkyl or wherein the two groups R2 and R3 together with the carbon atom to which they are bonded form a three- to eight-membered ring; R4, R5, R6 and R7 are identical or different and are eacType: GrantFiled: August 24, 1999Date of Patent: August 21, 2001Assignee: Syngenta Crop Protection, Inc.Inventor: Martin Zeller
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Patent number: 6268361Abstract: The present invention is related to methods for treating pathological conditions resulting from an estrogen deficiency, such as cardiovascular disease and osteoporosis, and is further related to methods for treating estrogen-dependent cancer, such as breast and uterine cancer, employing compounds of formula IType: GrantFiled: June 6, 1995Date of Patent: July 31, 2001Inventor: Alan D. Palkowitz
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Patent number: 6265433Abstract: The present invention provides compounds having the structure: and pharmaceutically acceptable salts and stereoisomers thereof that are useful in the treatment of inflammatory diseases which are mediated by LTB4 production, such as psoriasis, ulcerative colitis, IBD, and asthma.Type: GrantFiled: May 14, 1999Date of Patent: July 24, 2001Assignee: G. D. Searle & CompanyInventors: Barbara Baosheng Chen, Helen Chen, Mark Andrew Russell, Julie Marion Miyashiro, James Malecha, Thomas Dale Penning
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Patent number: 6258822Abstract: Compounds having the formula are inhibitors of urokinase and are useful in the treatment of diseases in which urokinase plays a role. Also disclosed are urokinase-inhibiting compositions and a method of inhibiting urokinase in a mammal.Type: GrantFiled: August 6, 1998Date of Patent: July 10, 2001Assignee: Abbott LaboratoriesInventors: Andrew G. Geyer, William J. McClellan, Todd W. Rockway, Kent D. Stewart, Moshe Weitzberg, Michael D. Wendt
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Patent number: 6255327Abstract: The invention relates to new diphenyl-substituted 5-ring heterocycles of general formula (I) wherein A, X and the groups R1, R2, R3, R4 and R5 are defined as in the claims, processes for preparing them and their use as pharmaceutical compositions.Type: GrantFiled: April 13, 1999Date of Patent: July 3, 2001Assignee: Boehringer Ingelheim Pharma KGInventors: Michael Brenner, Wolf-Dietrich Bechtel, Rainer Palluk, Marion Wienrich, Thomas Weiser, Enzo Cereda, Maura Bignotti, Carlo Maria Pellegrini
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Publication number: 20010005505Abstract: The present invention provides prophylactic and therapeutic methods of treating the ductal epithelium of an exocrine gland, in particular a mammary gland, for disease, in particular cancer. The methods comprise contacting the ductal epithelium of the exocrine gland with an epithelium-destroying gent, preferably by ductal cannulation, so as to realize a prophylactic or therapeutic effect.Type: ApplicationFiled: January 29, 1999Publication date: June 28, 2001Inventor: SARASWATI VAIDYANATHAN SUKUMAR
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Patent number: 6239164Abstract: This invention relates to methods of treating hair loss, through hair revitalization and germination, by administering non-immunosuppresive pyrrolidine carboxylate and pyrrolidine amide compounds.Type: GrantFiled: August 9, 1999Date of Patent: May 29, 2001Assignee: GPI NIL Holdings, Inc.Inventors: Joseph P. Steiner, Gregory S. Hamilton
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Patent number: 6221896Abstract: This invention relates to an insecticidal and miticidal composition which contains as active ingredients chlorfenapyr in combination with one or more compounds selected from the group consisting of benzoepin, nereistoxin-type insecticidal agents and diafenthiuron.Type: GrantFiled: May 24, 1999Date of Patent: April 24, 2001Assignee: American Cyanamid Co.Inventor: Toshiki Fukuchi
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Patent number: 6218423Abstract: This invention relates to pharmaceutical compositions and methods for treating a vision disorder, improving vision, treating memory impairment, or enhancing memory performance using pyrrolidine derivatives.Type: GrantFiled: August 14, 1998Date of Patent: April 17, 2001Assignee: GPI NIL Holdings, Inc.Inventors: Douglas T. Ross, Hansjörg Sauer, Gregory S. Hamilton, Joseph P. Steiner
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Patent number: 6218419Abstract: The subject application concerns novel compounds with useful biological properties. For example, these compounds can be used as antinflammatory, anti-proliferative, immunomodulatory, and/or neuroprotective agents. Specific examples of the compounds of the subject invention include Secobatzelline A and Secobatzelline B, which can be isolated from marine sponges.Type: GrantFiled: July 8, 1999Date of Patent: April 17, 2001Assignee: Harbor Branch Oceanographic Institution, Inc.Inventors: Sarath P. Gunasekera, Peter J. McCarthy, Ross E. Longley, Shirley A. Pomponi, Amy E. Wright
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Patent number: 6201008Abstract: The present invention provides a pesticidal composition which comprises 4-bromo-2-(4-chlorophenyl)-1-ethoxymethyl-5-trifluromethylpyrrole-3-carbonitrile and at least one pyrethroidal compound as active ingredients, and an inert carrier, and an insecticidal/acaricidal method applying 4-bromo-2-(4-chlorophenyl)-1-ethoxymethyl-5-trifluoromethylpyrrole-3-carbonitrile and at least one pyrethroidal compound to noxious insects, acarina, or the locus where noxious insects or acarina inhabit.Type: GrantFiled: June 29, 1999Date of Patent: March 13, 2001Assignee: Sumitomo Chemical Co. Ltd.Inventors: Yoji Takada, Izumi Fujimoto
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Patent number: 6191159Abstract: The present application describes disubstituted pyrazolines and triazolines of formulae I and II: or pharmaceutically acceptable salt forms thereof, wherein one of M1 and M2 maybe N and D may be a variety of N-containing groups, which are useful as inhibitors of factor Xa.Type: GrantFiled: March 26, 1999Date of Patent: February 20, 2001Assignee: Dupont Pharmaceuticals CompanyInventor: Donald J. P. Pinto
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Patent number: 6191142Abstract: Aroyl aminoacyl pyrroles are pharmaceutically useful in treating neuropathic pain, which includes utility for the treatment of neuropathic pain.Type: GrantFiled: February 17, 2000Date of Patent: February 20, 2001Assignee: Ortho-McNeil Pharmaceutical, Inc.Inventors: John R. Carson, Philip M. Pitis, Kathryn E. Rogers
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Patent number: 6174923Abstract: Compounds characterized generally as ethynyl alanine amino diol derivatives are useful to treat disorders mediated by plasma renin activity.Type: GrantFiled: January 28, 1999Date of Patent: January 16, 2001Assignee: G. D. Searle & Co.Inventors: Gunnar J. Hanson, John S. Baran
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Patent number: 6172087Abstract: This invention relates to pharmaceutical compositions and methods for treating alopecia and promoting hair growth using N-oxides of heterocyclic esters, amides, thioesters, or ketones.Type: GrantFiled: June 3, 1998Date of Patent: January 9, 2001Assignee: GPI NIL Holding, Inc.Inventors: Joseph P. Steiner, Gregory S. Hamilton
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Patent number: 6172083Abstract: A composition comprising effective amounts of a) a compound of the formula I or an N-oxide or salt thereof, wherein R1, R2, R3 and R4 are hydrogen, hydroxyl, nitro, halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio or haloalkylthio; R5, R6 and R7 are hydrogen, hydroxyl, cyano, nitro, halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio, hydroxyalkyl, acyl, aryl or aryloxy, wherein the aryl groups are optionally substituted, and e) a compound of the formula V wherein R10 is fluorine or chlorine; R11 is trifluoromethyl or chlorine, or R10 and R11 together are a group —OCF2O—, exhibits a synergisitc fungicidal effect.Type: GrantFiled: January 18, 2000Date of Patent: January 9, 2001Assignee: BASF AktiengesellschaftInventors: Oliver Wagner, Karl Eicken, Herbert Bayer, Hubert Sauter, Eberhard Ammermann, Gisela Lorenz
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Patent number: 6172091Abstract: Compounds of Formula I wherein the substituents are as described in the specification or pharmaceutically acceptable salts or stereochemically isomeric forms thereof, useful for treating diseases related to calcium imbalance and metabolism.Type: GrantFiled: October 13, 1999Date of Patent: January 9, 2001Assignee: Ortho-McNeil Pharmaceutical, Inc.Inventors: Judith Hope Cohen, Donald Ward Combs, Philip James Rybczynski
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Patent number: 6162830Abstract: The present invention provides compounds and pharmaceutical compositions thereof, and methods of using same in the treatment of diseases whose treatment benefits from the inhibition of phosphodiesterase (PDE-IV) or Tumor Necrosis Factor (TNF) including asthma, allergic diseases, rheumatoid arthritis, osteoarthritis, septic shock. The compounds provided by this invention have formula (I) wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 are as defined herein.Type: GrantFiled: February 7, 2000Date of Patent: December 19, 2000Assignee: Warner-Lambert CompanyInventors: David Thomas Connor, Joseph Peter Menetski
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Patent number: 6159995Abstract: Compounds of formula (I) ##STR1## are suitable for the production of pharmaceuticals for the prophylaxis and therapy of disorders in the course of which an increased activity of matrix-degrading metalloproteinases is involved.Type: GrantFiled: May 8, 1998Date of Patent: December 12, 2000Assignee: Aventis Pharma Deutschland GmbHInventors: Werner Thorwart, Wilfried Schwab, Manfred Schudok, Burkhard Haase, Bernhard Neises, Gunter Billen
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Patent number: 6156796Abstract: The present invention is directed to fungicidal compositions for agricultural and horticultural use, characterized in that the composition comprises a benzamidoxime composed represented by a general formula [I]: ##STR1## wherein R.sup.1 represents alkyl, alkenyl, etc., R.sup.2 represents phenyl, heterocycle, etc., X.sup.1 represents haloalkyl, X.sup.2, X.sup.3, X.sup.4 and X.sup.5 each independently represent hydrogen, halogeno, alkyl, etc., r.sub.1 and r.sub.2 each independently represent hydrogen, halogeno, alkyl, etc., and a so-called acrylate fungicide as the active ingredients. The fungicidal compositions according to the present invention are combination compositions of fungicidal components, which can improve fungicidal activity obtainable with each component in the combination with a less dose in total of each components.Type: GrantFiled: December 4, 1998Date of Patent: December 5, 2000Assignee: Nippon Soda Co., Ltd.Inventors: Shinsuke Sano, Homare Yamanaka
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Patent number: 6156784Abstract: Disclosed are compositions containing compounds of the formula (I) below wherein A,B,C,G,Q and R are defined herein. The compounds are useful as phosphotyrosine mimics that, when incorporated into an appropriate molecular structure, inhibit the binding of tyrosine kinase-dependent regulatory proteins to their native phosphotyrosine-containing ligands or receptors. Also disclosed are methods for preparing the compounds of the formula (I).Type: GrantFiled: December 7, 1999Date of Patent: December 5, 2000Assignee: Boehringer Ingelheim Pharmaceuticals, Inc.Inventors: Rajashekhar Betageri, Jean-Marie Ferland, Montse Llinas-Brunet, Neil Moss, John R. Proudfoot
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Patent number: 6133303Abstract: The present invention provides compounds of Formula (I). The present invention also provides a method of treating cancer and treating or preventing restenosis or atherosclerosis. Also provided by the present invention is a pharmaceutically acceptable composition containing a compound of Formula (I).Type: GrantFiled: August 2, 1999Date of Patent: October 17, 2000Assignee: Warner-Lambert CompanyInventors: Jack Bikker, Ellen Myra Dobrusin, Annette Marian Doherty, Matthew Drowns, James Stanley Kaltenbronn, Juergen Kleinschroth, Dennis Joseph McNamara, John Quin, III, Joseph Thomas Repine, Marcin Stasiak
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Patent number: 6110958Abstract: Compounds of formula (I) ##STR1## wherein the substituents are as defined herein, are antiparasitic agents.Type: GrantFiled: December 1, 1999Date of Patent: August 29, 2000Assignee: Pfizer Inc.Inventors: Bernard Joseph Banks, Nathan Anthony Logan Chubb
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Patent number: 6107331Abstract: The present invention provides novel methods of inhibiting pathological conditions related to organ systems which respond to estrogen agonists comprising administering to a mammal in need of such treatment an effective amount of a compound of formula I ##STR1##Type: GrantFiled: February 21, 1997Date of Patent: August 22, 2000Assignee: Pfizer Inc.Inventors: David B. MacLean, David D. Thompson
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Patent number: 6103733Abstract: An HDL cholesterol level inducing compound and a method of administering the compound having the structural formula I. ##STR1## wherein n is 1 or 2;R.sub.1 is a heteroaromatic substituent independently selected from a five-membered heteroaromatic ring having at least one N heteroatom, a six-membered heteroaromatic ring having at least one N heteroatom, or a fused ring system having at least one five-membered heteroaromatic ring having at least one N heteroatom;R.sub.2 is independently selected from --H or phenyl; andR.sub.3 is independently selected from --H, --CH.sub.3, --OH, phenyl, phenyl substituted with Cl, OCH.sub.3, CH.sub.3, or F, fused phenyl ring system, or six-membered heteroaromatic ring having at least one N heteroatom.Type: GrantFiled: September 9, 1998Date of Patent: August 15, 2000Inventors: Kenneth A. Bachmann, James T. Slama
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Patent number: 6096747Type: GrantFiled: May 28, 1996Date of Patent: August 1, 2000Assignee: Celltech Therapeutics LimitedInventors: Nigel Robert Arnold Beeley, Thomas Andrew Millican
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Patent number: 6083965Abstract: Compounds of formula (I): ##STR1## wherein the substituents are as defined herein, are antiparasitic agents.Type: GrantFiled: May 12, 1999Date of Patent: July 4, 2000Assignee: Pfizer IncInventors: Bernard Joseph Banks, Nathan Anthony Logan Chubb
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Patent number: 6077863Abstract: The present invention provides a method for the protection of wood, wood products and wooden structures from wood-eating insect attack and infestation which comprises treating said wood, wood product or wooden structure or the soil surrounding said wood, wood product or wooden structure with an insecticidally effective amount of an arylpyrrole compound of formula I.Type: GrantFiled: August 7, 1998Date of Patent: June 20, 2000Assignee: American Cyanamid CompanyInventors: Byron L. Reid, Robert A. Farlow
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Patent number: 6071947Abstract: The present invention relates to substituted (1H-indol-2-yl)-5[(2H-pyrrol-2-ylidene) methyl]-1H-pyrrole compounds and their use as immunomodulating agents, to the preparation of the compounds and to pharmaceutical compositions comprising them.Type: GrantFiled: November 12, 1998Date of Patent: June 6, 2000Assignee: Pharmacia & Upjohn S.p.A.Inventors: Roberto D'Alessio, Marcellino Tibolla, Alberto Bargiotti, Anna Maria Isetta, Mario Ferrari, Francesco Colotta
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Patent number: 6071951Abstract: The present invention provides a method for the control of subterranean termite populations which comprises applying to the soil a termiticidally effective amount of an arylpyrrole compound of formula I.Type: GrantFiled: August 7, 1998Date of Patent: June 6, 2000Assignee: American Cyanamid CompanyInventors: Byron L. Reid, Robert A. Farlow
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Patent number: 6066634Abstract: Substituted condensation products of N-benzyl-3-indenylacetamides with heterocyclic aldehydes are useful for inducing or promoting apotosis and for arresting uncontrolled neoplastic cell proliferation, and are specifically useful in the arresting and treatment of neoplasias, including precancerous and cancerous lesions.Type: GrantFiled: December 7, 1998Date of Patent: May 23, 2000Assignees: Cell Pathways, Inc., University of ArizonaInventors: Gerhard J. Sperl, Paul Gross, Klaus Brendel, Gary A. Piazza, Rifat Pamukcu
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Patent number: 6057342Abstract: The present application describes amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof of formula I: ##STR1## or pharmaceutically acceptable salt forms thereof, wherein one of D and D' may be C(.dbd.NH)NH.sub.2 and the other H, and J.sup.1 and J.sup.2 may be O or CH.sub.2, which are useful as inhibitors of factor Xa.Type: GrantFiled: July 7, 1997Date of Patent: May 2, 2000Assignee: Dupont Pharmaceutical Co.Inventors: John Matthew Fevig, Donald Joseph Phillip Pinto, Mimi Lifen Quan, Petrus Fredericus Wilhelmus Stouten
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Patent number: 6057358Abstract: Novel amine derivatives of the following general formula (I): ##STR1## (wherein) A may denote --(CH.sub.2)--O--, --(CH.sub.2).sub.2 --O--, or --(CH.sub.2).sub.2 --NH--;B may denote --(CH.sub.2).sub.2 --;R.sub.1 may denote a hydrogen atom, a halogen atom, a nitro group, a 1-pyrrolyl group, an acetamido group, an amino group or a dimethylamino group;R.sub.2 may denote a hydrogen atom or a nitro group;R.sub.3 and R.sub.4 may denote a hydrogen atom;R.sub.8a and R.sub.8b which are the same may denote a chlorine atom or a methoxy group;R.sub.9 may denote a hydrogen atom or an amino group;R may denote a methyl group; andX may denote a methanesulfonamido group, a 1-imidazolyl group or a nitro group or a salts thereof are useful as antiarrhythmic drugs.Type: GrantFiled: May 27, 1997Date of Patent: May 2, 2000Assignee: C&C Research Labs.Inventors: You Sup Chung, Hak Yeop Kim, Kyung Yun Jung, Jae Ki Min, Shigeru Tanabe
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Patent number: 6054457Abstract: This invention relates to new benzamide derivatives having a vasopressin antagonistic activity, etc, and represented by general formula (I): ##STR1## wherein R.sup.1 is aryl optionally substituted with lower alkoxy, etc., R.sup.2 is lower alkyl, etc.,R.sup.3 is hydrogen, etc.,R.sup.4 is lower alkoxy, etc.,R.sup.5 is hydrogen, etc.,A is NH, etc.,E is ##STR2## etc., X is --CH.dbd.CH--, --CH.dbd.N--, or S, andY is CH or N,and pharmaceutically acceptable salts thereof, to processes for preparation thereof and to a pharmaceutical composition comprising the same.Type: GrantFiled: December 9, 1997Date of Patent: April 25, 2000Assignee: Fujisawa Pharmaceutical Co., Ltd.Inventors: Hiroyuki Setoi, Takehiko Ohkawa, Tatsuya Zenkoh, Hitoshi Sawada, Kentaro Sato, Hirokazu Tanaka
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Patent number: 6051573Abstract: Compositions of non-steroidal glucocorticoid antagonists for treating GLC1A glaucoma and methods for their use are disclosed.Type: GrantFiled: December 19, 1997Date of Patent: April 18, 2000Assignee: Alcon Laboratories, Inc.Inventor: Abbot F. Clark
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Patent number: 6030985Abstract: The present invention relates to methods and compositions useful for treating and preventing conditions in which inhibition of nitric oxide synthetase is beneficial. These conditions include stroke, schizophrenia, anxiety, and pain.Type: GrantFiled: July 8, 1998Date of Patent: February 29, 2000Assignee: Astra AktiebolagInventors: Robert James Gentile, Robert John Murray, James Edwin MacDonald, William Calvin Shakespeare
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Patent number: 6028098Abstract: A compound of the general formula (I): Q--R--X wherein Q is a substituted or unsubstituted furanyl, imidazolyl, pyrrolyl or thiopheneyl group, R is CR.sup.1.sub.2 --Cr.sup.2.sub.2, (cis)CR.sup.1 .dbd.CR.sup.2, or (trans)-CR.sup.1 .dbd.CR.sup.2, X is COOR.sup.3 or NR.sup.1 R.sup.4, and R.sup.1 -R.sup.4 are each, independently, H, an alkyl or an aryl group and pharmaceutically acceptable salts thereof, are described for use in topical treatments of skin conditions which involve an overactive immune response, or which are responsive to UV irradiation. Pharmaceutical compositions of the compound of general formula (I) are also described.Type: GrantFiled: February 9, 1996Date of Patent: February 22, 2000Assignee: Bioglan Ireland (R&D) LimitedInventors: Michael Goodman, James Ferguson