Additional Hetero Ring Patents (Class 514/444)
  • C7 carbonate taxane compositions
    Publication number: 20040138267
    Abstract: Taxanes having a carbonate substituent at C(7), a hydroxy substituent at C(10), and a range of C(2), C(9), C(14), and side chain substituents.
    Type: Application
    Filed: December 22, 2003
    Publication date: July 15, 2004
    Applicant: FSU Research Foundation Inc.
    Inventor: Robert A. Holton
  • Active substance combinations having insecticidal and acaricidal properties
    Patent number: 6762183
    Abstract: The invention relates to novel active compound combinations of certain cyclic ketoenols and certain active compounds that together have unexpectedly good insecticidal and acaricidal properties.
    Type: Grant
    Filed: October 7, 2002
    Date of Patent: July 13, 2004
    Assignee: Bayer Aktiengesellschaft
    Inventors: Reiner Fischer, Christoph Erdelen, Thomas Bretschneider
  • Modulation of anxiety through blockade of anandamide hydrolysis
    Publication number: 20040127518
    Abstract: Fatty acid amide hydrolase inhibitors of the Formula: 1
    Type: Application
    Filed: October 7, 2003
    Publication date: July 1, 2004
    Applicant: The Regents of the University of California
    Inventors: Daniele Piomelli, Andrea Duranti, Andrea Tontini, Marco Mor, Giorgio Tarzia
  • Antiviral compounds
    Patent number: 6756391
    Abstract: The present invention is drawn to novel antiviral compounds, pharmaceutical compositions and their use. More specifically this invention is drawn to derivatives of monocyclic polyamines which have activity in standard tests against HIV-infected cells as well as other biological activity related to binding of ligands to chemokine receptors that mediate a number of mammalian embryonic developmental processes.
    Type: Grant
    Filed: May 9, 2002
    Date of Patent: June 29, 2004
    Assignee: AnorMed, Inc.
    Inventors: Gary James Bridger, Eva Maria Boehringer, Zhongren Wang, Dominique Schols, Renato Tony Skerlj, David Earl Bogucki
  • C10 carbonate taxane compositions
    Publication number: 20040122055
    Abstract: Taxanes having a carbonate substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.
    Type: Application
    Filed: November 24, 2003
    Publication date: June 24, 2004
    Applicant: FSU Research Foundation Inc.
    Inventor: Robert A. Holton
  • C7 carbamate substituted taxanes
    Patent number: 6750245
    Abstract: Taxanes having a carbamoyloxy substituent at C(7), a hydroxy substituent at C(10, and a range of C(2), C(9), C(14), and side chain substituents.
    Type: Grant
    Filed: February 6, 2002
    Date of Patent: June 15, 2004
    Assignee: FSU Research Foundation, Inc.
    Inventor: Robert A. Holton
  • Potassium channel inhibitors and method
    Publication number: 20040058931
    Abstract: Indanes, benzopyrans and analogues thereof are potassium channel inhibitors and blockers of IKur and have the structure 1
    Type: Application
    Filed: November 15, 2002
    Publication date: March 25, 2004
    Inventors: John Lloyd, Heather J. Finlay, Wayne Vaccaro, Karnail S. Atwal, Michael F. Gross, Kerry L. Spear
  • 5-Substituted-3(2H)-furanones useful for inhibition of farnesyl-protein transferase
    Patent number: 6710078
    Abstract: Compounds of Formula (I): wherein R1, R2, R3, X, Y, Z and Q are as defined in the specification which compounds are inhibitors of Ras farnesyl-protein transferase enzyme (FPTase), and useful in treating ras oncogene-dependent tumors, such as cancers of the pancreas, colon, bladder, and thyroid and processes for the preparation of said compounds of Formula (I).
    Type: Grant
    Filed: August 23, 2002
    Date of Patent: March 23, 2004
    Assignee: Wyeth Holdings Corporation
    Inventors: Semiramis Ayral-Kaloustian, Irwin Hollander, Ann Aulabaugh
  • Anti-cancer compounds
    Patent number: 6699854
    Abstract: The present invention relates to 2-substituted 4-heteroaryl-pyrimidines, their preparation, pharmaceutical compositions containing them and their use as inhibitors of cyclin-dependent kinases (CDKs) and hence their use in the treatment of proliferative disorders such as cancer, leukaemia, psoriasis and the like.
    Type: Grant
    Filed: December 20, 2002
    Date of Patent: March 2, 2004
    Assignee: Cyclacel Limited
    Inventors: Shudong Wang, Peter M. Fischer
  • Aromatic sulfone hydroxamates and their use as protease inhibitors
    Patent number: 6689794
    Abstract: This invention is directed to aromatic sulfone hydroxamates (also known as “aromatic sulfone hydroxamic acids”) and salts thereof that, inter alia, inhibit matrix metalloproteinase (also known as “matrix metalloprotease” or “MMP”) activity and/or aggrecanase activity. This invention also is directed to a prevention or treatment method that comprises administering such a compound or salt in an MMP-inhibiting and/or aggrecanase-inhibiting effective amount to an animal, particularly a mammal having (or disposed to having) a pathological condition associated with MMP and/or aggrecanase activity.
    Type: Grant
    Filed: May 10, 2002
    Date of Patent: February 10, 2004
    Assignee: Pharmacia Corporation
    Inventors: John N. Freskos, Yvette M. Fobian, Thomas E. Barta, Daniel P. Becker, Louis J. Bedell, Terri L. Boehm, Jeffery N. Carroll, Gary A. DeCrescenzo, Susan L. Hockerman, Darren J. Kassab, Steve A. Kolodziej, Joseph McDonald, Deborah A. Mischke, Monica B. Norton, Joseph G. Rico, John J. Talley, Clara I. Villamil, Lijuan Jane Wang
  • Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
    Publication number: 20040023999
    Abstract: Compounds of Formula (IA) and Formula (IB) 1
    Type: Application
    Filed: March 21, 2003
    Publication date: February 5, 2004
    Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Younes Bekkali, Rajashehar Betageri, Mario G. Cardozo, Thomas A. Gilmore, Christian Hanke Justus Joachim Harcken, Thomas M. Kirrane, Daniel Kuzmich, John Robert Proudfoot, Doris Riether, Hidenori Takahashi, David S. Thomson, Ji Wang, Renee Zindell, Hossein Razavi
  • Nf-kb inhibitors
    Publication number: 20040024047
    Abstract: The present invention provides novel compounds and methods for treating diseases with aminothiophene inhibitors of IKK-&bgr; phosphorylation of I&kgr;B.
    Type: Application
    Filed: April 10, 2003
    Publication date: February 5, 2004
    Inventors: James F. Callahan, Amy K. Roshak
  • Cryptophycin compounds
    Patent number: 6680311
    Abstract: The present invention provides cryptophycin compounds of Formula I that are useful in the treatment of neoplasms.
    Type: Grant
    Filed: February 25, 1998
    Date of Patent: January 20, 2004
    Assignees: Eli Lilly and Company, Wayne State University, University of Hawaii
    Inventors: Rima S Al-Awar, William J Ehlhardt, Subbaraju V Gottumukkala, Michael J Martinelli, Eric D Moher, Richard E Moore, John E Munroe, Bryan H Norman, Vinod F Patel, James E Ray, Chuan Shih, John E Toth, Venkatraghavan Vasudevan
  • Novel thiophene amidines, compositions thereof, and methods of treating complement-mediated diseases and conditions
    Publication number: 20040009995
    Abstract: Disclosed is a method for treating the symptoms of an acute or chronic disorder mediated by the classical pathway of the complement cascade, comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound of Formula I 1
    Type: Application
    Filed: May 28, 2003
    Publication date: January 15, 2004
    Applicant: 3-Dimensional Pharmaceuticals, Inc.
    Inventors: Nalin Subasinghe, Ehab Khalil, Kristi Leonard, Farah Ali, Heather Rae Hufnagel, Jeremy M. Travins, Shelley K. Ballentine, Kenneth T. Wilson, Maxwell D. Cummings, Wenxi Pan, Joan Gushue, Sanath Meegalla, Mark Wall, Jinsheng Chen, M. Jonathan Rudolph, Hui Huang
  • (R)-Chiral halogenated substituted heteroaryl benzyl aminoalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity
    Patent number: 6677341
    Abstract: The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases. Novel high yield, stereoselective processes for the preparation of the chiral substituted alkanol compounds from chiral and achiral intermediates are described. Preferred (R)-Chiral 1-Substitutedamino-(n+1)-Alkanol compounds are substituted (R)-Chiral heteroaryl aminoalcohols.
    Type: Grant
    Filed: December 12, 2001
    Date of Patent: January 13, 2004
    Assignee: Pharmacia Corporation
    Inventors: James A. Sikorski, Richard C. Durley, Margaret L. Grapperhaus, Mark A. Massa, Emily J. Reinhard, Yvette M. Fobian, Michael B. Tollefson, Lijuan Wang, Brian S. Hickory, Monica B. Norton, William F. Vernier, Deborah A. Mischke, Michele A. Promo, Ashton T. Hamme, Dale P. Spangler, Melvin L. Rueppel
  • C7 heterosubstituted acetate taxanes
    Patent number: 6673833
    Abstract: Taxanes having a heterosubstituted acetate substituent at C(7), a hydroxy substituent at C(10), and a range of C(2), C(9), C(14), and side chain substituents.
    Type: Grant
    Filed: February 2, 2001
    Date of Patent: January 6, 2004
    Assignee: FSU Research Foundation, Inc.
    Inventor: Robert A. Holton
  • Sulfoxide and bis-sulfoxide compounds and compositions for cholesterol management and related uses
    Patent number: 6673780
    Abstract: The present invention relates to novel sulfoxide and bis-sulfoxide compounds, compositions comprising sulfoxide and bis-sulfoxide compounds, and methods useful for treating and preventing cardiovascular diseases, dyslipidemias, dysproteinemias, and glucose metabolism disorders comprising administering a composition comprising an ether compound. The compounds, compositions, and methods of the invention are also useful for treating and preventing Alzheimer's Disease, Syndrome X, peroxisome proliferator activated receptor-related disorders, septicemia, thrombotic disorders, obesity, pancreatitis, hypertension, renal disease, cancer, inflammation, and impotence. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
    Type: Grant
    Filed: October 11, 2001
    Date of Patent: January 6, 2004
    Assignee: Esperion Therapeutics, Inc.
    Inventors: Jean-Louis Henri Dasseux, Carmen Daniela Oniciu
  • GlyT-1 inhibitors
    Patent number: 6667336
    Abstract: The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of the formula: or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: February 15, 2002
    Date of Patent: December 23, 2003
    Assignees: NPS Allelix Corp., Allelix Neuroscience, Inc.
    Inventors: Zhaoqing Wang, William Delaney, Ashok Tehim, Shawn Maddaford, Ian Egle, Richard Schumacher, Allen T. Hopper
  • C10 heterosubstituted acetate taxanes
    Patent number: 6664275
    Abstract: Taxanes having a heterosubstituted acetate substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.
    Type: Grant
    Filed: February 2, 2001
    Date of Patent: December 16, 2003
    Assignee: FSU Research Foundation, Inc.
    Inventor: Robert A. Holton
  • Pharmaceuticals for neurogenic pain
    Patent number: 6664283
    Abstract: This invention relates to pharmaceuticals for neuropathic pains comprising an mGluR1 receptor antagonist for systemic administration. Drugs efficacious in treating various neuropathic pain can be provided by the invention.
    Type: Grant
    Filed: May 15, 2002
    Date of Patent: December 16, 2003
    Assignee: Yamanouchi Pharmaceutical Co., Ltd.
    Inventors: Masamichi Okada, Yukinori Nagakura, Tetsuo Kiso, Takashi Toya, Satoshi Hayashibe
  • C10 carbonate substituted taxanes
    Patent number: 6660866
    Abstract: Taxanes having a carbonate substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.
    Type: Grant
    Filed: February 2, 2001
    Date of Patent: December 9, 2003
    Assignee: PSU Research Foundation, Inc.
    Inventor: Robert A. Holton
  • Compounds useful in the complement, coagulat and kallikrein pathways and method for their preparation
    Patent number: 6653340
    Abstract: The present invention is concerned with new compounds, and particularly those having a fused bicyclic ring substituted with an amidine moiety. These compounds are each potent inhibitors of Factor D of the alternate pathway of complement, C1s of the classical pathway of complement, Factors Xa, XIIa, VIIa and thrombin of the coagulation pathway, plasmin in the fibrinolytic pathway, and kallikrein and high molecular weight kininogen in the inflammatory pathways. These proteases, which have serine in their active site, are called serine proteases and they are pivotal to most of the processes of inflammation and coagulation. In fact, these various systems are interactive with one another and it is difficult to activate one pathway without it influencing the others.
    Type: Grant
    Filed: September 27, 2000
    Date of Patent: November 25, 2003
    Assignee: BioCryst Pharmaceuticals, Inc.
    Inventors: Yarlagadda S. Babu, J. Claude Bennett, Shri Niwas, R. Scott Rowland
  • C10 ester substituted taxanes
    Patent number: 6649632
    Abstract: Taxanes having an ester substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.
    Type: Grant
    Filed: February 2, 2001
    Date of Patent: November 18, 2003
    Assignee: FSU Research Foundation, Inc.
    Inventor: Robert A. Holton
  • Method of treating colonic adenomas
    Patent number: 6649649
    Abstract: This invention is directed to a method of retarding or preventing the transformation of a colonic adenoma to a colonic adenocarcinoma comprising the administration to a patient with FAP or a patient with one or more of said adenomas a non-toxic therapeutically effective amount of NSAID, said amount effective to inhibit the PGHS-2 in said adenoma. The preferred method comprises the administration of a specific PGHS-2 inhibiting agent as defined herein.
    Type: Grant
    Filed: March 2, 1999
    Date of Patent: November 18, 2003
    Assignees: Merck & Co., Inc., Merck Frosst Canada, & Co.
    Inventors: Stacia Kargman, Thomas J. Simon, Jilly Evans
  • Methods of treating infection by drug resistant bacteria
    Publication number: 20030199516
    Abstract: Methods are provided for treating an infection by Gram-positive bacteria in a mammal, by administering to the mammal an effective amount of a compound that binds noncovalently in the minor groove of duplex DNA, the compound being identified by a number of DNA binding parameters and, in many instances, being a polyaromatic compound.
    Type: Application
    Filed: September 12, 2002
    Publication date: October 23, 2003
    Applicant: Genesoft, Inc.
    Inventors: Heinz E. Moser, Eldon E. Baird, Roland W. Burli, Yigong Ge, Sarah White
  • Method of treatment with compounds having retinoid-like activity and reduced skin toxicity and lacking teratogenic effects
    Patent number: 6624188
    Abstract: A process and pharmaceutical compositions for treating several diseases and conditions which are normally treatable with retinoid like compounds are disclosed where the compound used for the treatment are substantially non-teratogenic and not irritant to the skin. The process is useful for treating female mammals, including humans, who are pregnant or in the child bearing age. An important partial structural feature of the compounds which provides the non-teratogenic effect and lack of irritation of skin is shown by the formula where the partially drawn ring signifies an aromatic ring which may be carbocyclic or heteroaromatic, 6-membered or 5-membered, and may be condensed with another ring. R1 is lower alkyl, Cl, Br, or I, R2 is H, lower alkyl, Cl, Br, or I, and R3 is lower alkyl, Cl, Br, I, or is an ether, thioether, ester, thioester, amine or substituted amine group.
    Type: Grant
    Filed: March 23, 1994
    Date of Patent: September 23, 2003
    Assignee: Allergan, Inc.
    Inventor: Roshantha A. S. Chandraratna
  • GLYT-1 INHIBITORS
    Publication number: 20030176489
    Abstract: The invention provides a pharmaceutical for treatment of neurological and neuropsychiatric disorders comprising a compound of the formula: 1
    Type: Application
    Filed: February 15, 2002
    Publication date: September 18, 2003
    Inventors: Zhaoqing Wang, William Delaney, Ashok Tehim, Shawn Maddaford, Ian Egle, Richard Schumacher, Allen T. Hopper
  • Substituted 6H-DiBenzo[c,h]chromenes as estrogenic agents
    Publication number: 20030176491
    Abstract: This invention provides estrogen receptor modulators of formula I, having the structure 1
    Type: Application
    Filed: December 11, 2002
    Publication date: September 18, 2003
    Applicant: Wyeth
    Inventors: Richard E. Mewshaw, Richard J. Edsall, Stephen T. Cohn, Heather A. Harris, James C. Keith, Leo M. Albert
  • Selenophene anti-tumor agents
    Patent number: 6620804
    Abstract: Novel selenophene compounds useful as anti-tumor agents are described. Preferred compounds include compounds of formula I: wherein R1 and R2 are independently selected from the group consisting of; H, CHO, CH2OH and CH2NH2; and X and Y are independently selected from the group consisting of Se, S, O, NCH3 and NH. Pharmaceutical compositions and a method for treating patients having tumors utilizing the disclosed selenophene compounds are also described.
    Type: Grant
    Filed: February 1, 2002
    Date of Patent: September 16, 2003
    Assignee: Purdue Research Foundation
    Inventors: Ching-jer Chang, Curtis L. Ashendel, Darrick Kim
  • Small organic molecule regulators of cell proliferation
    Patent number: 6613798
    Abstract: The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as the compounds depicted in FIGS. 32 and 33. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: September 2, 2003
    Assignee: Curis, Inc.
    Inventors: Jeffrey Porter, Oivin M. Guicherit, Lee Rubin, Anthony David Baxter, Edward Andrew Boyd, Stephen Price
  • Heterocyclic sulfonamide inhibitors of beta amyloid production
    Patent number: 6610734
    Abstract: Compounds of Formula (I), wherein R1, R2, R3, R4, R5, R6, T, W, X, Y and Z are as defined herein are provided, together with pharmaceutically acceptable salt, hydrates and/or prodrugs thereof. Methods of using these compounds for inhibiting beta amyloid production and for treatment of Alzheimer's Disease and Down's syndrome are described.
    Type: Grant
    Filed: December 11, 2001
    Date of Patent: August 26, 2003
    Assignees: Wyeth, ArQule Inc.
    Inventors: Anthony F. Kreft, Derek C. Cole, Kevin R. Woller, Joseph R. Stock, George Diamantidis, Dennis M. Kubrak, Kristina M. Kutterer, William J. Moore, David S. Casebier, Lynn Resnick
  • Non-psychotropic cannabinoids
    Patent number: 6610737
    Abstract: Novel non-psychotropic cannabinoids are disclosed and pharmaceutical compositions comprising these novel compounds are described for preventing neurotoxicity, neuroinflammation, immune or inflammatory disorders comprising as active ingredient the stereospecific (+) enantiomer, having (3S,4S) configuration of &Dgr;6 tetrahydrocannabinol type compounds. The compositions are particularly effective in alleviating and even preventing neurotoxicity due to acute injuries to the central nervous system, including mechanical trauma, compromised or reduced blood supply as may occur in cardiac arrest or stroke, or poisonings. They are also effective in the treatment of certain inflammatory disorders and chronic degenerative diseases characterized by neuronal loss and chronic pain including neuropathic pain.
    Type: Grant
    Filed: November 26, 2002
    Date of Patent: August 26, 2003
    Assignee: Pharmos Corporation
    Inventors: Aaron Garzon, George Fink
  • Antibiotic oxazolidinone derivatives
    Patent number: 6605630
    Abstract: The invention concerns a compound of the formula (I): wherein, for example: T is of the formula (IA), (IB), or (IC); R1 is of the formula —NHC(═O)Rb wherein Rb is (1-4C)alkyl; R2 and R3 are hydrogen or fluoro; >A—B— is >C═CH— (but not when T is (IA)) or >CH—CH2—; wherein when T is of the formula (IA) or (IB); R6 is, for example, (1-4C)alkyl; R5 is hydrogen, R10CO—, R10SO2— or R10CS— wherein R10 is, for example, optionally substituted phenyl, or (1-10C)alkyl, or when T is of the formula (IA), (IB); or (IC): R5 and R6 are linked to give a 5- or 6-membered ring which is fused to the ring shown in (IA), (IB), or (IC) so as to give an optionally substituted bicyclic ring; and pharmaceutically acceptable salts thereof, processes for their preparation, pharmaceutical compositions containing them, and their use as antibacterial agents.
    Type: Grant
    Filed: February 18, 2000
    Date of Patent: August 12, 2003
    Assignee: Syngenta Limited
    Inventor: Michael Barry Gravestock
  • Substituted cyclic compounds, preparation method and pharmaceutical compositions containing them
    Patent number: 6605632
    Abstract: The invention concerns compounds of formula (I): R—A—R′ wherein: A is as defined in the description; R represents a group (V), (VI), (VII) or (VIII), where E, Q, R1, R2, R3, v and R4 are as defined in the description; R′ represents a —(CH2)t—R5 group wherein t and R5 are as defined in the description
    Type: Grant
    Filed: November 10, 2000
    Date of Patent: August 12, 2003
    Assignee: Les Laboratoires Servier
    Inventors: Daniel Lesieur, Frédérique Klupsch, Gérald Guillaumet, Marie-Claude Viaud, Michel Langlois, Caroline Bennejean, Pierre Renard, Philippe Delagrange
  • C10 carbamoyloxy substituted taxanes
    Patent number: 6596737
    Abstract: Taxanes having a carbamoyloxy substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.
    Type: Grant
    Filed: February 2, 2001
    Date of Patent: July 22, 2003
    Assignee: FSU Research Foundation, Inc.
    Inventors: Robert A. Holton, Weishuo Fang
  • Method for treating fibrotic diseases with azolium chroman compounds
    Patent number: 6596745
    Abstract: Provided is a method of treating or ameliorating hypertension in an animal comprising administering an effective amount of a compound of formula I:
    Type: Grant
    Filed: May 30, 2002
    Date of Patent: July 22, 2003
    Assignee: Alteon, Inc.
    Inventor: Martin Gall
  • Method of treating colonic adenomas
    Patent number: 6593361
    Abstract: This invention is directed to a method of retarding or preventing the transformation of a colonic adenoma to a colonic adenocarcinoma comprising the administration to a patient with FAP or a patient with one or more of said adenomas a non-toxic therapeutically effective amount of NSAID, said amount effective to inhibit the PGHS-2 in said adenoma. The preferred method comprises the administration of a specific PGHS-2 inhibiting agent as defined herein.
    Type: Grant
    Filed: October 12, 2001
    Date of Patent: July 15, 2003
    Inventors: Stacia Kargman, Jilly Evans, Thomas J. Simon
  • Methods of treating cytokine mediated diseases
    Publication number: 20030130309
    Abstract: Disclosed are methods of treating certain cytokine mediated diseases or conditions using novel aromatic heterocyclic compounds of the formula(I) wherein Ar1,Ar2,L,Q and X are described herein.
    Type: Application
    Filed: July 1, 2002
    Publication date: July 10, 2003
    Applicant: Boehringer Ingelheim Pharmaceuticals, Inc.
    Inventors: Neil Moss, John Robinson Regan
  • Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
    Publication number: 20030130279
    Abstract: The present invention relates to compounds with the formula (I) 1
    Type: Application
    Filed: November 22, 2002
    Publication date: July 10, 2003
    Inventors: Guido Kurz, Marianne Nilsson, Jerk Vallgarda, Meredith Williams
  • Substituted aminoalkylamide derivatives as antagonists of follicle stimulating hormone
    Patent number: 6583179
    Abstract: The present invention is directed to a series of novel substituted aminoalkylamide derivatives, pharmaceutical compositions containing them and their use in the treatment of reproductive disorders and affective conditions. Further, the compounds of the invention are antagonists of follicle stimulating hormone, a hormone associated with the human reproductive system.
    Type: Grant
    Filed: December 21, 2000
    Date of Patent: June 24, 2003
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Steven J. Coats, Louis J. Fitzpatrick, Dennis J. Hlasta, Carolina L. Lanter, Mark J. Macielag, Ke Pan, Ralph A. Rivero, Stephen S. Palmer
  • C10 carbonate substituted taxanes
    Publication number: 20030114493
    Abstract: Taxanes having a carbonate substituent at C(10), a hydroxy substituent at C(7), and a range of C(2), C(9), C(14), and side chain substituents.
    Type: Application
    Filed: February 2, 2001
    Publication date: June 19, 2003
    Inventor: Robert A. Holton
  • Method for treating allergies using substituted pyrazoles
    Patent number: 6579896
    Abstract: A method for the treatment of an allergic condition, including an an atopic allergic conditions, using substituted pyrazoles.
    Type: Grant
    Filed: September 5, 2001
    Date of Patent: June 17, 2003
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Hui Cai, James P. Edwards, Yin Gu, Lars Karlsson, Steven P. Meduna, Barbara A. Pio, Siquan Sun, Robin L. Thurmond, Jianmei Wei
  • Active substance combinations having insecticidal and acaricidal properties
    Publication number: 20030100604
    Abstract: The novel active compound combinations of certain cyclic ketoenols and the active compounds (1) to (43) listed in the description have very good insecticidal and acaricidal properties.
    Type: Application
    Filed: September 20, 2002
    Publication date: May 29, 2003
    Inventors: Reiner Fischer, Christoph Erdelen, Thomas Bretschneider
  • 5,6,7-trinor-4,8-inter-m-phenylene PGI2, derivative and drugs containing the same
    Patent number: 6555559
    Abstract: The present invention provides novel PGI2 derivatives and an anti Helicobacter agent, a platelet function potentiating agent or a cervical ripening agent containing any of the derivatives.
    Type: Grant
    Filed: August 1, 2000
    Date of Patent: April 29, 2003
    Assignee: Toray Industries, Inc.
    Inventors: Hisanori Wakita, Naohiro Yamada, Hitoshi Hatakeyama, Takeshi Ishigaki, Noriyuki Hirano, Takeshi Mori
  • Sulfonamide lactam inhibitors of FXa and method
    Patent number: 6555542
    Abstract: Sulfonamide lactams of the following formula wherein X, R1, R2, R3, R4, R4a, R5, R5a, R6, R6a, R7 and R8 are as described herein, are provided which inhibitors of Factor Xa and are useful as anticoagulants in the treatment of cardiovascular diseases associated with thromboses.
    Type: Grant
    Filed: January 29, 2002
    Date of Patent: April 29, 2003
    Assignee: Bristol-Myers Squibb Company
    Inventors: Stephen P. O'Connor, Michael Lawrence, Yan Shi, Philip D. Stein
  • Synergistic analgesic combination of oxycodone and rofecoxib
    Patent number: 6552031
    Abstract: Disclosed is a pharmaceutical composition, comprising a combination of a dose of rofecoxib or a pharmaceutically acceptable salt thereof and a dose of oxcodone or a pharmaceutically acceptable salt thereof, said combination in an amount sufficient to provide an analgesic effect in a human patient. Also disclosed is a method of effectively treating pain in humans or other mammals, comprising administering to the patient a combination of a dose of rofecoxib or a pharmaceutically acceptable salt thereof and a dose of oxycodone or a pharmaceutically acceptable salt thereof such that the dosing interval of the rofecoxib overlaps with the dosing interval of the oxycodone, said combination in an amount sufficient to provide an analgesic effect in a human patient.
    Type: Grant
    Filed: September 17, 1998
    Date of Patent: April 22, 2003
    Assignee: Euro-Celtique S.A.
    Inventors: Ronald M. Burch, Paul D. Goldenheim, Richard S. Sackler
  • Pharmaceutical compounds and methods of use thereof
    Publication number: 20030055084
    Abstract: The present invention provides substituted benzofuran, indene, thianaphthene and oxidized thianaphthene compounds and methods of treatment and pharmaceutical compositions that comprise such compounds. Preferred compounds of the invention contain benzofuran, indene or thianaphthene group substituted with a tetrahydrofuran or other alicyclic group.
    Type: Application
    Filed: July 30, 2002
    Publication date: March 20, 2003
    Applicant: Millennium Pharmaceutical, Inc.
    Inventors: Gurmit Grewal, Ralph Scannell, Xiong Cai, Michelle Young, Aberra Fura
  • Bromonitrothienyldioxanes
    Publication number: 20030040540
    Abstract: The invention relates to novel 5-bromo-5-nitro-2-thienyl-1,3-dioxanes of the formula (I) 1
    Type: Application
    Filed: July 3, 2002
    Publication date: February 27, 2003
    Inventors: Hermann Uhr, Karl-Heinz Kuck, Martin Kugler, Peter Wachtler
  • N-substituted sulfonamide derivatives
    Patent number: 6525099
    Abstract: The present invention provides certain N-substituted sulfonamide derivatives useful for potentiating glutamate receptor function in a mammal and therefore, useful for treating a wide variety of conditions, such as psychiatric and neurological disorders.
    Type: Grant
    Filed: January 23, 2001
    Date of Patent: February 25, 2003
    Assignee: Eli Lilly and Company
    Inventors: Macklin Brian Arnold, Winton Dennis Jones, Paul Leslie Ornstein, Hamideh Zarrinmayeh, Dennis Michael Zimmerman
  • 3?-alkyl substituted taxanes and pharmaceutical compositions containing them
    Patent number: 6521660
    Abstract: Taxane derivatives having an alkyl substituted C13 side chain.
    Type: Grant
    Filed: April 29, 2002
    Date of Patent: February 18, 2003
    Assignee: Florida State University
    Inventors: Robert A. Holton, Ki-Byung Chai, Hamid Idmoumaz, Hossain Nadizadeh, Yukio Suzuki