Chalcogen Bonded Directly To Ring Carbon Of The Hetero Ring Patents (Class 514/455)
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Patent number: 5374653Abstract: Iridoid derivatives synthesized using genipin, which is an aglycon of geniposide, as the starting material are useful as an anti-hyperlipemia agent and as a cholagogue.Type: GrantFiled: August 17, 1993Date of Patent: December 20, 1994Assignee: Tsumura & Co.Inventors: Yuichi Fujii, Ichiro Arai, Akira Hatta, Akemi Tatsugi, Hiroshi Mitsuhashi, deceased, Mieko Mitsuhashi, legal representative, Hiroyuki Mitsuhashi, legal representative, Tomoaki Mitsuhashi, legal representative, Masaharu Kigawa
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Patent number: 5371104Abstract: The invention relates to a process for the solubilzation of forskolin, to the pharmaceutical compositions based on such solubilized forskolin and to the use of these in the treatment of various diseases and disorders and maladies in mammals, including human. Forskolin is 7-beta-acetoxy-8,13-epoxy-1-alpha,6-beta,9-alpha-trihydroxylabd-14-en-11-o ne.Type: GrantFiled: February 18, 1994Date of Patent: December 6, 1994Inventor: Jeffery J. Feigenbaum
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Patent number: 5360816Abstract: A pharmaceutical formulation comprising 5-methoxy psoralen, which is useful in the treatment of psoriasis and other skin disorders, is disclosed herein. 5-methoxy psoralen may be synthesized from phloroglucinol by a five step process which is also disclosed.Type: GrantFiled: May 4, 1992Date of Patent: November 1, 1994Inventor: Jean-Jacques Goupil
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Patent number: 5356929Abstract: The invention features phototherapeutic compositions comprising Type 1, Type 2, or Type 3 psoralens and methods of using such compounds for treatment of proliferative diseases of skin, blood and bone marrow.Type: GrantFiled: April 23, 1993Date of Patent: October 18, 1994Assignee: Lehigh UniversityInventors: Ned D. Heindel, Jeffrey D. Laskin
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Patent number: 5354774Abstract: A method for inhibiting smooth muscle cell proliferation in an injured blood vessel includes the steps of administering a photoactivatable psoralen to a patient in an amount to achieve local arterial tissue levels of psoralen suitable for light-dependent inhibition of smooth muscle cell growth, and delivering radiation in the visible wavelength range to the injured region of the blood vessel at a level sufficient for photoactivation of the psoralen. The psoralen is preferably 8-methoxypsoralen and can be delivered systemically or locally. The method of the invention can be used for preventing restenosis in a blood vessel following transluminal angioplasty. Both the psoralen and the visible light can be delivered with a laser balloon catheter having a porous balloon. The method of the invention may also be used for inhibiting proliferation of other undesired cell types in a patient's body.Type: GrantFiled: December 24, 1992Date of Patent: October 11, 1994Assignee: Yale UniversityInventors: Lawrence I. Deckelbaum, Francis P. Gasparro, Bauer K. Sumpio
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Patent number: 5346917Abstract: 1-[[(Dialkylamino)alkyl]amino]-4-substituted-thioxanthen-9-ones are disclosed as antitumor agents. Compositions containing the thioxanthenones and methods of treating tumors and cancer in mammals with the thioxanthenones are also disclosed.Type: GrantFiled: April 8, 1993Date of Patent: September 13, 1994Assignee: Sterling Winthrop Inc.Inventors: Theodore C. Miller, Joseph C. Collins, Kenneth C. Mattes, Mark P. Wentland, Robert B. Perni, Thomas H. Corbett, Joseph W. Guiles
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Patent number: 5336685Abstract: A method of inhibiting the growth of multidrug resistant cancer cells which comprises contacting multidrug resistant cancer cells with an effective amount of a flavonoid compound. Also, a composition for inhibiting the growth of multidrug resistant cancer cells which comprises a physiologically acceptable carrier and an amount of a flavonoid compound.Type: GrantFiled: April 12, 1993Date of Patent: August 9, 1994Assignee: Sloan-Kettering Institute for Cancer ResearchInventors: Hans J. Prochaska, Kathleen W. Scotto
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Patent number: 5320949Abstract: The present invention relates to an aglucone isoflavone enriched vegetable protein fiber wherein a vegetable protein material is extracted to form a slurry of protein, fiber and glucone isoflavones. The pH of the slurry is adjusted to about 6 to 8 and the slurry reacted with a beta glucosidase to convert the glucone isoflavones in said slurry to aglucone isoflavones. The fiber fraction is then recovered from the slurry by centrifugation or similar means to provide an aglucone enriched fiber.Type: GrantFiled: October 12, 1993Date of Patent: June 14, 1994Assignee: Protein Technologies International, Inc.Inventor: Jerome L. Shen
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Patent number: 5284868Abstract: A pharmaceutical compound of the formula ##STR1## in which n is 0, 1 or 2 and R.sup.1 is attached at any of the positions 5, 6, 7, 8, 9 or 10, and each R.sup.1 is halo, trifluoromethyl, C.sub.1-4 alkoxy, hydroxy, nitro, C.sub.1-4 alkyl, C.sub.1-4 alkylthio, hydroxy-C.sub.1-4 alkyl, hydroxy-C.sub.1-4 alkoxy, trifluoromethoxy, carboxy, --COOR.sup.5 where R.sup.5 is an ester group, --CONR.sup.6 R.sup.7 or --NR.sup.6 R.sup.7 where R.sup.6 and R.sup.7 are each hydrogen or C.sub.1-4 alkyl; R.sup.2 is phenyl, naphthyl or heteroaryl selected from thienyl, pyridyl, benzothienyl, quinolinyl, benzofuranyl or benzimidazolyl, said phenyl, naphthyl and heteroaryl groups being optionally substituted, or R.sup.2 is furanyl optionally substituted with C.sub.1-4 alkyl; R.sup.3 is nitrile, carboxy, --COOR.sup.8 where R.sup.8 is an ester group, --CONR.sup.9 R.sup.10 where R.sup.9 and R.sup.10 are each hydrogen or C.sub.1-4 alkyl, or R.sup.11 SO.sub.2 -- where R.sup.11 is C.sub.1-4 alkyl or optionally substituted phenyl; and R.Type: GrantFiled: September 25, 1992Date of Patent: February 8, 1994Assignees: Eli Lilly and Company, Lilly Industries LimitedInventors: Colin P. Dell, Jai P. Singh, Colin W. Smith
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Patent number: 5284869Abstract: The occurence of restenosis following percutaneous transluminal coronary angioplasty is prevented or inhibited using a photopheresis treatment method. In accordance with the photopheresis treatment method, a photoactive compound such as 8-methoxypsoralen is administered to the patient's blood or affected tissue, or some fraction thereof, in vitro or in vivo using conventional administration routes. A portion of the patient's blood or affected tissue is then treated (preferably, extracorporeally) using photopheresis, which comprises subjecting the blood or affected tissue to electromagnetic radiation in a wavelength suitable for activating the photoactive compound, such as ultraviolet light, preferably long wavelength ultraviolet light in the wavelength range of 320 to 400 nm, commonly called UVA light. The treated blood or affected tissue, or a fraction thereof, is returned to the patient (in the case of extracoporeal photopheresis) or remains in the patient (following in vivo photopheresis).Type: GrantFiled: December 17, 1991Date of Patent: February 8, 1994Inventors: Emil Bisaccia, Albert S. Klainer
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Patent number: 5281620Abstract: The novel class of xanthenone-4-acetic acids represented by the general formula (I) ##STR1## where R.sub.1 represents up to two of the groups lower alkyl, halogen, CF.sub.3, CN, NO.sub.2, NH.sub.2, CH.sub.2 COOH, OR.sub.2, OH, NHCOR.sub.2, NHSO.sub.2 R.sub.2, SR.sub.2, SO.sub.2 R.sub.2, CH.sub.2 CONHR.sub.2 or NHR.sub.2 (where R.sub.2 is lower alkyl optionally substituted with hydroxy, amino or methoxy functions), at any of the positions 1-8 which are available, R.sub.1 may also represent the substitution of an aza (--N.dbd.) group for one or two of the methine (--CH.dbd.) groups in the carbocyclic rings and two of R.sub.1 on any two available adjacent positions may also represent the grouping --CH.dbd.CH--CH.dbd.CH-- to form an additional fused benzene ring;and basic addition salts thereof, possess antitumour and antibacterial properties.Type: GrantFiled: July 13, 1992Date of Patent: January 25, 1994Assignee: Cancer Research Campaign Technology LimitedInventors: William A. Denny, Bruce C. Baguley, Graham J. Atwell, Gordon W. Rewcastle
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Patent number: 5276053Abstract: A novel series of polycyclic amines, derivatives, methods of making the compounds, novel intermediates, compositions containing them, and methods for using them in the treatment and prevention of cerebrovascular disorders are disclosed.Type: GrantFiled: October 6, 1992Date of Patent: January 4, 1994Assignee: Warner-Lambert CompanyInventor: Graham Johnson
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Patent number: 5276054Abstract: Substituted hexahydrobenzopyran derivatives of the Formulae A, B, or C are useful as angiotensin II antagonists: ##STR1##Type: GrantFiled: October 16, 1992Date of Patent: January 4, 1994Assignee: Merck & Co., Inc.Inventors: Maria T. Diez, Michael A. Goetz, Robert A. Giacobbe, Otto D. Hensens, Leeyan Huang, Isabel Martin, E. Tracy T. Jones, Siobhan Stevens-Miles, Yu L. Kong
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Patent number: 5273998Abstract: The present invention provides an industrially valuable method for preparing an optically active 3,4-dihydro-3,4-epoxy-2H-1-benzopyran compound which is useful as a starting material for an optically active benzopyran compound with antihypertensive, coronary blood flow-increasing activities and the like, provides a diastereomeric ester compound which is useful as an intermediate for said epoxy compound and also provides a use of said diastereomeric ester compound in making of said epoxy compound, and further an optically active benzopyran compound which is useful as medicine.Type: GrantFiled: October 19, 1992Date of Patent: December 28, 1993Assignee: Yoshitomi Pharmaceutical Industries, Ltd.Inventor: Tsutomu Yamanaka
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Patent number: 5264454Abstract: Novel heterocyclic compound of the general formula: ##STR1## wherein ring A and ring B each means a benzene ring which is substituted or unsubstituted; X means a group of the formula: ##STR2## wherein R.sup.2 is hydrogen, an alkyl or an alkoxy; m is 0 or 1, the formula: ##STR3## wherein R.sup.3 is hydrogen or an alkyl, or the formula: --O--CO--; Y means a bond, --NH--, an C.sub.1 or 2 alkylene group or --CH.dbd.CH--; R.sup.1 means a hydrocarbon group which is substituted or unsubstituted; and n means a whole number of 3 through 6, or a salt thereof, having excellent acyl-CoA:cholesterol acyltransferase inhibitory activity, and a method for preparing it and its use.Type: GrantFiled: September 25, 1991Date of Patent: November 23, 1993Assignee: Takeda Chemical Industries, Ltd.Inventors: Kanji Meguro, Hiroyuki Tawada, Hitoshi Ikeda
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Patent number: 5259701Abstract: Certain furan compounds are disclosed as being useful as marine or fresh water antifoulant compounds to be used in protective carrier compositions such as film forming polymer to protect fish nets, boats, pilings, and piers.Type: GrantFiled: October 22, 1992Date of Patent: November 9, 1993Assignee: Rohm and Haas CompanyInventors: Donald L. Gerhart, Daniel Rittschof, Irving R. Hooper, Anthony Clare
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Patent number: 5256648Abstract: A method of inhibiting the function of targeted DNA in a viable cell comprising administering to a viable cell containing targeted DNA a therapeutically effective amount of a photoactivatable composition comprising the UVA irradiation product of a compound that has two photoactivatable functional groups, and an oligonucleotide of DNA whose sequence of bases (a) contains at least one TA or AT sequence and (b) is substantially complementary to a segment of cellular DNA of the targeted DNA in the cell, and irradiating the cell with UVA light.Type: GrantFiled: September 21, 1989Date of Patent: October 26, 1993Assignee: Yale UniversityInventors: Francis P. Gasparro, Richard L. Edelson
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Patent number: 5252598Abstract: The present invention relates to labdane-derivatives of the formula ##STR1## a process for their preparation and the use of these substances as medicaments, preferably as medicaments having a positive ionotropic effect, an effect of lowering intraocular pressure and lowing blood pressure.Type: GrantFiled: May 4, 1992Date of Patent: October 12, 1993Assignee: Hoechst AktiengesellschaftInventors: Yatendra Khandelwal, Greta Moraes, Bansi Lal, Vijay A. Aroskar, Alihussein N. Dohadwalla, Richard H. Rupp
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Patent number: 5248221Abstract: Certain gamma lactones are disclosed as being useful as marine or fresh water antifoulant compounds to be used in protective carrier compositions such as film forming polymer to protect fish nets, boats, pilings, and piers.Type: GrantFiled: October 22, 1992Date of Patent: September 28, 1993Assignee: Rohm and Haas CompanyInventors: Donald J. Gerhart, Daniel Rittschof, Irving R. Hooper
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Patent number: 5232942Abstract: The present invention relates to Q-2819 substance represented by formula described below and a process for production thereof as well as a novel microorganism capable of producing the substance: ##STR1##Type: GrantFiled: November 29, 1990Date of Patent: August 3, 1993Assignee: Yamanouchi Pharmaceutical Co., Ltd.Inventors: Harumitsu Imai, Hidenori Yazawa, Koji Nagai, Takeshi Saito, Shu F. Liang
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Patent number: 5232943Abstract: Antibiotic Mer-AF1032A represented by the following formula (I) and its isomer antibiotic Mer-AF1032B are disclosed. Also disclosed are a method for preparing the antibiotics comprising the cultivation of a strain belonging to genus Penicillium and a pharmaceutical composition comprising one of these antibiotics and useful as an antifungal agent.Type: GrantFiled: May 20, 1992Date of Patent: August 3, 1993Assignee: Mercian CorporationInventors: Hitosi Agematu, Yoshio Watanabe, Hiroyuki Chiba, Rei Kaneto, Norio Shibamoto, Takeo Yoshioka, Toshihiko Kumamoto, Hiroshi Nishida, Rokuro Okamoto
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Patent number: 5229123Abstract: The compound of the formula ##STR1## and its tautomer are obtained from cultures of Eupenicillium sp. The compound has antifungal activity.Type: GrantFiled: September 18, 1992Date of Patent: July 20, 1993Assignee: Hoffmann-La Roche Inc.Inventors: Miyako Masubuchi, Toru Okuda, Hisao Shimada
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Patent number: 5221608Abstract: Method for treating nucleic acid that is to be amplified such that the nucleic acid is, after amplification, subsequently unamplifiable. Nucleic acid amplification is performed in a reaction containing means in the presence of an isopsoralen. The reaction is thereafter irradiated to render the amplified nucleic acid substantially unamplifiable.Type: GrantFiled: October 26, 1989Date of Patent: June 22, 1993Inventors: George D. Cimino, John E. Hearst, Stephen T. Isaacs, Kenneth C. Metchette, John W. Tessman
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Patent number: 5219882Abstract: A method is provided for treating human patients who have Lymes disease by using a psoralen compound, preferably administered in a dosage of 0.3 to 0.7 mg/kg, and activating same either in vitro or in vivo using electromagnetic radiation of a prescribed activating wavelength. The activation of the psoralen compound in the presence of a blood fraction from a patient suffering from Lymes disease produces a composition which will stimulate an effective immune response to the Lymes disease on the part of the patient.Type: GrantFiled: October 24, 1991Date of Patent: June 15, 1993Inventors: Emil Bisaccia, Albert S. Klainer
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Patent number: 5216014Abstract: The present invention provides novel furocoumarinsufonamide derivatives having the formula ##STR1## wherein R.sub.1, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are independently H or lower alkyl; m, n and p are independently 2, 3, 4, 5 or 6; A is NR.sub.4 (CH.sub.2).sub.P NR.sub.5, NR.sub.6, O or S; R.sub.2 is independently H, lower alkyl or a moiety of the formula ##STR2## useful for inhibiting protein kinase C and treating conditions related to, or affected by inhibition of protein kinase C, particularly cancer tumors, inflammatory disease, reperfusion injury, and cardiac dysfunctions related to reperfusion injury.Type: GrantFiled: September 10, 1991Date of Patent: June 1, 1993Assignee: Sphinx Pharmaceuticals CorporationInventors: Jack B. Jiang, Mary G. Johnson
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Patent number: 5206241Abstract: Labdanes of the formula ##STR1## a process for their manufacture, pharmaceutical preparations containing an effective amount of these compounds and their use for the manufacture of a pharmaceutical preparation for treatment of cardiovascular diseases and high intraocular pressure.Type: GrantFiled: March 14, 1991Date of Patent: April 27, 1993Assignee: Hoechst AktiengesellschaftInventors: Yatendra Khandelwal, Rajeshwari Kannan, Bansi Lal, Ramanujam Rajagopalan, Vijay A. Aroskar, deceased AliHussein N. Dohadwalla, Rashida A. Dohadwalla, Anis S. Dohadwalla, Samina A. Dohadwalla, Richard H. Rupp
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Patent number: 5204368Abstract: The present invention relates to compounds of the class of coal-derived fulvic acid or a salt or a derivative thereof as active ingredient in a suitable carrier, useful as a bactericidal or bacteriostatic agent. The carrier is preferably water.Type: GrantFiled: May 7, 1991Date of Patent: April 20, 1993Assignee: National Energy CouncilInventors: Izak J. Cronje, Thomas E. Cloete, Johannes Dekker, Hendrik Swart
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Patent number: 5200425Abstract: This invention relates to improvements to drugs containing as an active substance the 5-methoxypsoralene of formula: ##STR1##Type: GrantFiled: November 1, 1990Date of Patent: April 6, 1993Inventor: Jean-Jacques Goupil
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Patent number: 5198462Abstract: A novel heterocyclic amine derivative of the general formula: ##STR1## wherein a ring A and a ring B stand independently for an optionally substituted benzene ring, Z.degree. stands for O or S or ##STR2## stands for --CH.sub.2 --, X stands for O, S or NR.sup.1 wherein R.sup.1 stands for hydrogen atom or an alkyl group, Y stands for NH, O or (CH.sub.2).sub.n wherein n denotes 0 to 2, and R.sup.2 stands for an optionally substituted hydrocarbon group, or their salts.Type: GrantFiled: October 16, 1991Date of Patent: March 30, 1993Assignee: Takeda Chemical Industries, Ltd.Inventors: Hideaki Natsugari, Hiroyuki Tawada, Hitoshi Ikeda
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Patent number: 5192765Abstract: Amines of the following formula: ##STR1## where the variables are defined in the specification are useful in the treatment of diseases associated with altered motility and/or tone of smooth muscle.Type: GrantFiled: June 6, 1991Date of Patent: March 9, 1993Assignee: Pfizer Inc.Inventors: David Alker, Robert J. Bass, Peter E. Cross
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Patent number: 5182298Abstract: This invention relates to compounds of structural formula (I) ##STR1## which are useful as Cholestrol lowering agents.Type: GrantFiled: March 18, 1991Date of Patent: January 26, 1993Assignee: Merck & Co., Inc.Inventors: Gregory L. Helms, Wendy S. Horn, E. Tracy T. Jones, David L. Linemeyer
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Patent number: 5180717Abstract: Bivalent ligand compounds synthesized from a tether composition joining two heterocyclic groups comprising furochromones, furobenzoxazinones, and benzobisdifurans. These compounds show pharmacological activity in blocking ACAT enzymes which are major regulators of cholesterol metabolism. The compounds also show activity in lowering plasma triglycerides and elevating HDL cholesterol. They are useful in the prevention or treatment of the constriction or obstruction of arterial vessels, atherosclerosis, hyperlipidemia, hypertriglyceridemia, chylomicronemia, and pancreatitis.Type: GrantFiled: May 7, 1991Date of Patent: January 19, 1993Assignee: The Upjohn CompanyInventors: Ronald B. Gammill, Frank P. Bell
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Patent number: 5180736Abstract: A novel series of polycyclic amines, derivatives, methods of making the compounds, novel intermediates, compositions containing them, and methods for using them in the treatment and prevention of cerebrovascular disorders are disclosed.Type: GrantFiled: May 17, 1991Date of Patent: January 19, 1993Assignee: Warner-Lambert CompanyInventor: Graham Johnson
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Patent number: 5176919Abstract: Pharmaceutical and cosmetic compositions comprising extracts of Ammi visnaga and Ammi majus or the vasoactive agents contained therein are described.Type: GrantFiled: September 20, 1990Date of Patent: January 5, 1993Assignee: Indena, S.p.A.Inventors: Sergio Bertini Curri, Ezio Bombardelli
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Patent number: 5166217Abstract: This invention relates to methods for inhibiting fungal growth employing compounds of formula (I) ##STR1##Type: GrantFiled: November 26, 1991Date of Patent: November 24, 1992Assignee: Merck & Co., Inc.Inventors: Kenneth F. Bartizal, Walter Rozdilsky, Wendy S. Horn
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Patent number: 5145855Abstract: Novel forskolin derivatives, intermediates and processes for the preparation thereof, and methods for treating cardiac failure and memory deficit utilizing compounds or compositions thereof are disclosed.Type: GrantFiled: November 15, 1991Date of Patent: September 8, 1992Assignee: Hoechst Roussel Pharmaceuticals, Inc.Inventors: Raymond W. Kosley, Jr., Bettina Spahl
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Patent number: 5141942Abstract: Pharmaceutical compositions comprising labdane diterpenoid derivatives and pyrimido(6,1-a)-isoquinolin-4-one derivatives when administered to the skin of a mammal or of the man increase the rate of terminal hair growth, stimulate the conversion of vellus hair to growth as terminal hair and arrest hair loss. They can be used for the treatment of several kinds of alopecia.Type: GrantFiled: November 17, 1989Date of Patent: August 25, 1992Assignee: Hoechst AktiengesellschaftInventors: Bansi Lal, Jurgen Blumbach, Alihussein N. Dohadwalla, Noel J. de Souza
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Patent number: 5141953Abstract: Use of the antibiotic purpuromycin for the topical treatment of infectious vaginitis and topical dosage forms containing said product. The antibiotic purpuromycin is simultaneously active against the main causative agents of infectious vaginitis i.e.: Candida vaginalis, Trichomonas vaginalis and Gardnerella vaginalis.Type: GrantFiled: March 22, 1990Date of Patent: August 25, 1992Assignee: Gruppo Lepetit S.p.A.Inventors: Francesco Parenti, Beth P. Goldstein, Luigi Simioni
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Patent number: 5139940Abstract: The invention is directed to isopsoralen compound compositions that contain a variety of substitutions which yet permit their binding to nucleic acid polymers. Reaction conditions that activate these bound isopsoralens results in covalent crosslinking to the nucleic acid polymers. The resultant complex is inhibited from being a template for the template-directed enzymatic synthesis of a complementary nucleic acid polymer. Beside the isopsoralens compositions, the invention includes their synthesis, the nucleic acid complex production and detection, and the above inhibitory method of use of the isopsoralens.Type: GrantFiled: October 26, 1989Date of Patent: August 18, 1992Inventors: Stephen T. Isaacs, Goerge D. Cimino, Kenneth C. Metchette, John W. Tessman
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Patent number: 5130332Abstract: Novel oxolabdanes, intermediates and processes for the preparation thereof, and methods for reducing intraocular pressure utilizing compounds or compositions thereof are disclosed.Type: GrantFiled: February 11, 1991Date of Patent: July 14, 1992Assignee: Hoechst Roussel Pharmaceuticals Inc.Inventor: Nicholas J. Hrib
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Patent number: 5118705Abstract: Water soluble salts of purpuromycin, their use for the topical treatment of infectious vaginitis and topical dosage forms containing said products. Oral and parenteral formulations for administration of the water soluble purpuromycin salts. The water soluble salts of purpuromycin are simultaneously active against the main causative agents of infectious vaginitis i.e.: Candida vaginalis, Trichomonas vaginalis and Gardnerella vaginalis.Type: GrantFiled: February 25, 1991Date of Patent: June 2, 1992Assignee: Gruppo Lepetit S.p.A.Inventors: Aldo Trani, Sergio Bellini, Beth P. Goldstein, Luigi Simioni
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Patent number: 5118494Abstract: Pharmaceutical suspension aerosol formulations using one or more perfluorinated carboxylic acids or esters thereof as surface-active dispersing agents and 1,1,1,2-tetra-fluorethane or 1,1,1,2,3,3,3-heptafluoropropane as the propellant are described.Type: GrantFiled: March 13, 1991Date of Patent: June 2, 1992Assignee: Minnesota Mining and Manufacturing CompanyInventors: Robert K. Schultz, Stephen N. Quessy
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Patent number: 5116864Abstract: Restenosis following vascular recanalization is prevented by administering a photoactivatable psoralen and, in conjunction with recanalization, delivering ultraviolet radiation to the region of said recanalization.Type: GrantFiled: April 9, 1991Date of Patent: May 26, 1992Assignee: Indiana University FoundationInventors: Keith L. March, David R. Hathaway, Robert L. Wilensky, Brian L. Patton
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Preparation of T-cell and T-cell membrane for use in prevention and treatment of autoimmune diseases
Patent number: 5114721Abstract: Pharmaceutical preparations are provided for preventing or treating autoimmune diseases in which the active principle is activated T-lymphocyte cells, specific for the autoimmune disease to be treated, which cells have been treated by incubation with a photoactivatable psoralen cross-linking agent, such as 8-methoxypsoralen, and then photoactivated. The active principle may also be the membrane fraction of such cells. Such preparations may be formulated into pharmaceutical compositions and administered to prevent or treat autoimmune disesases.Type: GrantFiled: March 15, 1989Date of Patent: May 19, 1992Assignee: Yeda Research and Development Co. Ltd.Inventors: Irun R. Cohen, Meir Shinitzky, Richard L. Edelson -
Patent number: 5104894Abstract: Synthetic novel ellagic acid congeners of the formula: ##STR1## wherein: R.sub.1 is --H, --OH or --OR';R.sub.2 is --H, --OH or --OR';R.sub.3 is --H, --OH or --OR';R.sub.4 is --H, --OH or --OR';R.sub.5 is --H, --OH or --OR';R.sub.6 is --H, --OH or --OR';R' is lower alkyl having 1 to 8 carbon atoms or --CH.sub.2 --Ar;Ar is phenyl or substituted phenyl, and at least one of R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 is other than --H. The above compounds and 6H-dibenzo[b,d]pyran-6-one are useful for inhibiting mutagenic activity in living cells.Type: GrantFiled: March 8, 1988Date of Patent: April 14, 1992Assignee: University of GuelphInventors: Philip D. Josephy, Victor A. Snieckus
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Patent number: 5093106Abstract: The present invention is used for diagnosis, including early diagnosis, of malignant growths, for assessment as of the extent of malignant infection, for determining of the required volume for surgical intervention, for finalizing diagnoses under clinical and dispensary conditions, for control during the process of treatment of malignant tumors, and for detection of post-operative relapses.The contrasting composition according to the present invention is characterized in that, in addition to the contrasting composition, namely, fluorescein, or salts thereof, it comprises sugar.Type: GrantFiled: February 23, 1990Date of Patent: March 3, 1992Inventors: Nikolai N. Dzbanovsky, Viktor I. Polsachev, Elena V. Potemkina, Alexandr T. Rakhimov, Leonid B. Rubin, Alexandr S. Osipov
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Patent number: 5093331Abstract: The present invention relates to polyoxygenated labdane-derivatives of the formula ##STR1## a process for their preparation and the use of these substances as medicaments, preferably as medicaments having a positive inotropic effect, an effect of lowering intraocular pressure and lowering blood pressure.Type: GrantFiled: October 9, 1990Date of Patent: March 3, 1992Assignee: Hoechst AktiengesellschaftInventors: Bansi Lal, Ashok K. Gangopadbya, Alihussein N. Dohadwalla, Ramanujam Rajgopalan, Richard H. Rupp
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Patent number: 5093336Abstract: Novel forskolin derivatives, intermediates and processes for the preparation thereof, and methods for treating cardiac failure and memory deficit utilizing compounds or compositions thereof are disclosed.Type: GrantFiled: July 6, 1989Date of Patent: March 3, 1992Assignee: Hoechat-Roussel Pharmaceuticals, Inc.Inventors: Raymond W. Kosley, Jr., Bettina Spahl
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Patent number: 5071853Abstract: A novel series of polycyclic amines, derivatives, methods of making the compounds, novel intermediates, compositions containing them, and methods for using them in the treatment and prevention of cerebrovascular disorders are disclosed.Type: GrantFiled: February 27, 1990Date of Patent: December 10, 1991Inventors: Christopher F. Bigge, Sheryl J. Hays, Graham Johnson, Perry M. Novak, Daniel F. Ortwine
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Patent number: 5047412Abstract: The invention describes novel (2-styryl-, 2-naphthyl- and 2-phenethyl-4-o-hydroxyphenyl-1,3-dioxan-5-yl)alkenoic acids and related tetrazoles and sulphonamides, of the formula I wherein Q completes a benzene or pyridine ring, Y is vinylene, Z is carboxy, 1(H)-tetrazol-5-yl or a group of the formula --CO.NHSO.sub.2 R.sup.6, and R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, A.sup.1, A.sup.2, n and m have the meanings defined in the specification, and pharmaceutically acceptable salts thereof, for use in conjunction with their pharmaceutical compositions in treating certain pulmonary and/or vascular disorders. The invention also describes various processes and intermediates for the manufacture of the novel compounds.Type: GrantFiled: February 1, 1989Date of Patent: September 10, 1991Assignee: Imperial Chemical Industries PLCInventors: George R. Brown, Michael J. Smithers