Spiro Ring System Patents (Class 514/462)
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Publication number: 20090018176Abstract: The present invention relates to a fungicide composition comprising a N2-phenylamidine derivative and two other fungicide compounds, at least, as well as and the corresponding methods of protection by application of the said composition. This composition is intended for protecting crops against fungal diseases.Type: ApplicationFiled: September 12, 2006Publication date: January 15, 2009Applicant: Bayer CropScience AGInventors: Peter Dahmen, Thomas Seitz, Ulrike Wachendorff-Neumann
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Publication number: 20080317737Abstract: A topical treatment for skin disorders and diseases comprising a combination of at least one antifungal agent and at least one hydroxy acid agent formulated into shampoos, creams, lotions, gels, sprays, foams, pads, films, patches, and solutions for treatment of skin disorders and diseases in both humans and animals.Type: ApplicationFiled: June 19, 2008Publication date: December 25, 2008Inventors: Bhiku Patel, D. Craig Woodward, Philip J. Gordon
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Publication number: 20080305955Abstract: The invention relates to novel spiroketal-substituted cyclic ketoenols of the formula (I) in which A, B, Q1, Q2, D, G, W, X, Y, and Z are as defined above, to processes and intermediates for their preparation and to their use as pesticides and/or microbicides and/or herbicides. Moreover, the invention relates to selective herbicidal compositions comprising, firstly, spiroketal-substituted cyclic ketoenols and, secondly, a crop plant compatibility-improving compound.Type: ApplicationFiled: February 8, 2006Publication date: December 11, 2008Applicant: Bayer CropScience AGInventors: Thomas Bretschneider, Reiner Fischer, Oliver Gaertzen, Stefan Lehr, Mark Wilhelm Drewes, Dieter Feucht, Olga Malsam, Udo Reckmann, Christian Arnold, Thomas Auler, Waltraud Hempel, Martin Jeffrey Hills, Heinz Kehne, Christopher Hugh Rosinger, Erich Sanwald
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Publication number: 20080306013Abstract: The present invention provides illudin analogs of the general formula (I): where R1 is (CH2)n—X—Y or H; n is 0 to 4; X is O or S or N or absent; and Y is an optionally substituted (C1-C8)alkyl, (C6-C10)aryl, (C6-C10)aryl(C1-C4)alkyl or cyclo(C3-C6)alkyl optionally comprising one or more heteroatoms; a monosaccharide, an amino acid residue, or H when n is 2-4; R2 is absent; or R1 and R2 together comprise a 5-7 membered cyclic ring; R3 is (C1-C4)alkyl or H; R4 is H, SCH2CO2(C1-C4)alkyl, O—(C5-C12)aryl or —S—(C5-C12)aryl; R5 is H, OH or absent; R6 is (C1-C4)alkyl or absent; R7 is OH or OSi((C1-C4)alkyl)3; or R6 and R7 together are ethylenedioxy; R8 is optionally substituted (C1-C4)alkyl; and the bonds represented by --- are individually present or absent. The invention further provides dimers comprising analogs of formula (I).Type: ApplicationFiled: December 12, 2007Publication date: December 11, 2008Inventors: Trevor C. McMorris, Michael J. Kelner
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Publication number: 20080274893Abstract: The present invention relates to novel phenyl-substituted 4-ketolactams and -lactones of the formula (I) in which A, B, Q, G, W, X, Y, Z and R3 are as defined above, to processes and intermediates for their preparation and to their use as pesticides, microbicides and herbicides.Type: ApplicationFiled: July 8, 2008Publication date: November 6, 2008Inventors: Reiner Fischer, Astrid Ullmann, Thomas Bretschneider, Mark Wilhelm Drewes, Christoph Erdelen, Angelika Lubos-Erdelen, Dieter Feucht, Udo Reckmann
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Publication number: 20080255061Abstract: Disclosed a class of phthalide derivatives and the use of which to manufacture the sensitizer or reverser of the antineoplastic agent.Type: ApplicationFiled: September 30, 2005Publication date: October 16, 2008Inventors: Fei Chen, Tao Wang
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Publication number: 20080249088Abstract: A topical formula for treatment of antifungal infections of the skin and nails comprises: (a) a therapeutically effective amount of a benzylamine or morpholine antifungal compound; (b) an aliphatic alcohol substituted with an aromatic substituent in which the antifungal compound is soluble to a degree that a therapeutically effective concentration of the antifungal compound can be applied topically in solution; and (c) a distribution solvent or mixture of solvents in which the solvent mixture of parts (a) and (b) is soluble, and which has a boiling point that is less than about 110.degree.C. The benzylamine compound can be butenafine. The morpholine compound can be amorolfine. The aliphatic alcohol substituted with an aromatic substituent can be benzyl alcohol, or phenethyl alcohol. The distribution solvent mixture can include ethyl alcohol, water, or isopropyl alcohol. Alternatively, the formula can include a second antifungal compound.Type: ApplicationFiled: April 9, 2007Publication date: October 9, 2008Inventor: William L. Sherrett
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Publication number: 20080234283Abstract: This invention relates to compositions and methods for the treatment of neurodegenerative, pulmonary and inflammatory diseases described herein with glutathione peroxidase and its mimetics.Type: ApplicationFiled: February 19, 2008Publication date: September 25, 2008Inventor: Noah Berkowitz
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Publication number: 20080227855Abstract: A stable composition of an amorphous component (such as a bioactive) and a carrier polymer is formed by mixing a bridging polymer with the bioactive and the carrier polymer, wherein the bridging polymer is a hydrogen bond donor to both the bioactive and the carrier polymer, thereby forming a composition in which the bioactive and the carrier polymer have less of a tendency to crystallise than if the bridging polymer were not present.Type: ApplicationFiled: February 10, 2006Publication date: September 18, 2008Inventors: Graham Buckton, Stephen Brocchini, John Fletcher, Hisham Al-Obaidi
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Publication number: 20080207537Abstract: Application of a reducing agent followed by an oxidising agent to a nail substantially increases the permeability thereof, thereby enabling the passage of drugs across the nail.Type: ApplicationFiled: June 6, 2006Publication date: August 28, 2008Applicant: MedPharm LimitedInventors: Robert Turner, Marc Barry Brown, Stuart Allen Jones
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Patent number: 7417156Abstract: In only two steps and in 65% overall yield, natural trioxane artemisinin (I) was converted on gram scale into C-10-carba trioxane dimer (3). This new, very stable dimer was then transformed easily in one additional step into four different dimers (4-7). Alcohol and diol dimers (4 and 5) and ketone dimer (7) are 10 times more antimalarially potent in vitro than artemisinin (I), and alcohol and diol dimers (4 and 5) are strongly inhibitory but not cytotoxic toward several human cancer cell lines. Water-soluble carboxylic acid derivatives (8a-10c and 12) were easily prepared from dimers (4-6); they are thermally stable even at 60° C. for 24 hours, are more orally efficacious as antimalarials than either artelinic acid or sodium artesunate, and have potent and selective anticancer activities.Type: GrantFiled: September 26, 2003Date of Patent: August 26, 2008Assignee: Johns Hopkins UniversityInventors: Gary H. Posner, Theresa A. Shapiro, Surojit Sur, Tanzina Labonte, Kristina Borstnik, Ik-Hyeon Paik, Andrew J. McRiner
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Publication number: 20080200539Abstract: The present invention is a topical skin preparation for treatment of fungal infections of the skin and nails. The preparation comprises triacetin in combination with one or more antifungal agents. In a preferred form, the preparation comprises a combination of the antifungal agents tolnaftate and grisiofulvin are used in combination with triacetin. The concentrations of these constituents are 40 to 50% concentration triacetin, 30 to 50% acetone, 0.5-3.0% concentration tolnaftate and 0.5-4.0% concentration grisiofulvin, in one preferred embodiment. Other compounds, such as ethyl alcohol, acetone, amino acids such as n-acetylcysteine, and herbal additives may also be added to the preparation. Further, other antifungal agents such as nystatin, clortimazole, econazole, ketoconazole, miconazole, solconazole, oxiconizole, naftifine, terbinafine, and butenafine, for example, may be substituted for the antifungal agents tolnaftate and grisiofulvin.Type: ApplicationFiled: April 18, 2008Publication date: August 21, 2008Inventor: Alexander A. Bommarito
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Publication number: 20080171788Abstract: The invention relates to a medicament for IBS, which comprises a dual antagonist for 5-HT2B and 5-HT7 receptors having selective binding affinities for 5-HT2B and 5-HT7 receptors. The pharmaceutical composition of the invention is useful as a drug which is excellent in the therapeutic effect on IBS and shows lessened side effects occurring in the existing remedies for IBS, because it showed good pharmacological actions in comparison with the case of independently using a 5-HT2B receptor antagonist having selective binding affinity for 5-HT2B receptor or a 5-HT7 receptor antagonist having selective binding affinity for 5-HT7 receptor.Type: ApplicationFiled: February 7, 2006Publication date: July 17, 2008Inventors: Shinobu Akuzawa, Hiroyuki Ito, Toshihiro Watanabe, Hiroyoshi Yamada
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Publication number: 20080125411Abstract: A means and method for treating malaria, schistosomiasis, and cancer using a spiro or dispiro 1,2,4-trioxolane is described. The preferred 1,2,4-trioxolanes include a spiroadamantane group on one side of the trioxolane group, and a spirocyclohexyl on the other side of the trioxolane group. In comparison to artemisinin semisynthetic derivatives, the compounds of this invention are structurally simple, easy to synthesize, non-toxic, and potent against malarial parasites. The compounds of the invention unexpectedly provide a single-dose cure for malaria, as well as prophylactic activity against the same. The compounds are also active against schistosomiasis and cancer.Type: ApplicationFiled: October 31, 2007Publication date: May 29, 2008Applicant: MEDICINES FOR MALARIA VENTURE MMVInventors: JONATHAN L. VENNERSTROM, YUXIANG DONG, SUSAN A. CHARMAN, SERGIO WITTLIN, JACQUES CHOLLET, DARREN J. CREEK, XIAOFANG WANG, KAMARAJ SRIRAGHAVAN, LIN ZHOU, HUGUES MATILE, WILLIAM N. CHARMAN
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Publication number: 20080125441Abstract: A means and method for treating malaria, schistosomiasis, and cancer using a Spiro or dispiro 1,2,4-trioxolane is described. The preferred 1,2,4-trioxolanes include a spiroadamantane group on one side of the trioxolane group, and a spirocyclohexyl on the other side of the trioxolane group, whereby the spirocyclohexyl ring is preferably substituted at the 4-position. In comparison to artemisinin semisynthetic derivatives, the compounds of this invention are structurally simple, easy to synthesize, non-toxic, and potent against malarial parasites.Type: ApplicationFiled: October 31, 2007Publication date: May 29, 2008Applicant: MEDICINES FOR MALARIA VENTURE MMVInventors: JONATHAN L. VENNERSTROM, YUXIANG DONG, SUSAN A. CHARMAN, SERGIO WITTLIN, JACQUES CHOLLET, XIAOFANG WANG, KAMARAJ SRIRAGHAVAN, LIN ZHOU, HUGUES MATILE, WILLIAM N. CHARMAN
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Publication number: 20080119439Abstract: The present invention is directed to the use of lipoxin A4 analogs as therapeutic agents in the treatment and/or prevention of intestinal fibrosis.Type: ApplicationFiled: August 21, 2007Publication date: May 22, 2008Inventors: John Parkinson, Stefano Fiorucci
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Publication number: 20080112899Abstract: The present invention refers to cooling compounds of formula I wherein R1, R2, R3, X, Y, Z, and m have the same meaning as given in the specification. The present invention refers furthermore to a process for their production and to product compositions comprising them.Type: ApplicationFiled: November 21, 2005Publication date: May 15, 2008Inventors: Christophe C. Galopin, Stefan Michael Furrer, Jay Patrick Slack, Pablo Victor Krawec, Lucienne Cole
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Publication number: 20080114058Abstract: The present invention relates to the use of lignan compounds for treating or preventing an inflammatory disease. More particularly, it relates to a pharmaceutical composition for the treatment or prevention of an inflammatory disease, comprising a lignan compound represented by Formula I, as well as a treating method and the use of an inflammatory disease using the lignan compound. The lignan compound has the effect of inhibiting inflammatory reactions by inhibiting the production or expression of inflammation mediators NO, iNOS, PGE2, COX-2 and TNF-?. Accordingly, the lignan compound or a Myristica fragrans extract will be highly useful for the treatment or prevention of an inflammatory disease.Type: ApplicationFiled: January 6, 2006Publication date: May 15, 2008Inventors: Jae-Kwan Hwang, Do-Un Kim, Jae-Youn Chung, Hee-Chul Chung, Kyu-Lee Han
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Patent number: 7371778Abstract: A means and method for treating malaria, schistosomiasis, and cancer using a spiro or dispiro 1,2,4-trioxolane is described. The preferred 1,2,4-trioxolanes include a spiroadamantane group on one side of the trioxolane group, and a spirocyclohexyl on the other side of the trioxolane group, whereby the spirocyclohexyl ring is preferably substituted at the 4-position. In comparison to artemisinin semisynthetic derivatives, the compounds of this invention are structurally simple, easy to synthesize, non-toxic, and potent against malarial parasites.Type: GrantFiled: May 4, 2005Date of Patent: May 13, 2008Assignee: Medicines for Malaria Venture MMVInventors: Jonathan L. Vennerstrom, Yuxiang Dong, Jacques Chollet, Hugues Matile, Xiaofang Wang, Kamaraj Spiraghavan, William N. Chapman
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Patent number: 7354936Abstract: The present invention relates to 2-(4-sulphonylphenyl)pyran-4-one derivatives of general formula processes for their preparation, pharmaceutical compositions containing them, and their medical uses.Type: GrantFiled: September 16, 2002Date of Patent: April 8, 2008Assignee: Almirall AGInventors: Maria Isabel Crespo Crespo, Juan Miguel Jimenez Mayorga, Josep Lluis Matallana Julia, Joan Feixas Gras
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Patent number: 7332485Abstract: Novel PDF inhibitors and novel methods for their use are provided.Type: GrantFiled: July 8, 2004Date of Patent: February 19, 2008Assignee: SmithKline Beecham CorpInventors: Kelly M. Aubart, Siegfried Benjamin Christensen, IV, Chaya Duraiswami, Joseph M. Karpinski
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Patent number: 7297691Abstract: The present invention is concerned with treatment of sleep disorders by administering a cholinesterase inhibitor, and in particular, by administering galantamine or a pharmaceutically acceptable salt thereof. Also in particular, cholinesterase inhibitors that are active at nicotinic receptors and that are selective for acetylcholinesterase over butylcholinesterase are used in treating sleep disorders.Type: GrantFiled: August 11, 2004Date of Patent: November 20, 2007Assignee: Janssen Pharmaceutica N.V.Inventor: Michael Gold
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Publication number: 20070232689Abstract: The present invention is directed to novel 3,4-diamino-3-cyclobutene-1,2-dione derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders related to potassium channel.Type: ApplicationFiled: March 29, 2007Publication date: October 4, 2007Inventors: James C. Lanter, Zhihua Sui
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Patent number: 7276533Abstract: This invention features the use of the spirolaxine of formula (I) for the treatment of those pathologies responding to the activation of the PPAR? receptor, such as the Type 2 insulin-resistant diabetes. This invention also features a pharmaceutical composition in which the spirolaxine of formula (I) acts as active principle in association with the all-trans retinoic acid of formula (II) for the treatment of those pathologies responding to the activation of the PPAR? receptor, such as the acute malignant haemopathies.Type: GrantFiled: July 13, 2004Date of Patent: October 2, 2007Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.Inventors: Claudio Pisano, Teresa Riccioni
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Patent number: 7244750Abstract: The invention relates to novel active compound combinations of certain cyclic ketoenols and certain active compounds that together have unexpectedly good insecticidal and acaricidal properties.Type: GrantFiled: March 30, 2006Date of Patent: July 17, 2007Assignee: Bayer CropScience AktiengesellschaftInventors: Reiner Fischer, Christoph Erdelen, Thomas Bretschneider
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Patent number: 7241741Abstract: The present invention provides methods for the treatment of respiratory tract mucositis in individuals in need of such treatment, the method comprising the systemic administration to the individual of therapeutically effective amounts of at least one anti-fungal agent and at least one anti-bacterial agent, wherein the treatment does not involve the cessation of use of emollients by the individual. The present invention also provides compositions suitable for use in the treatment of respiratory tract mucositis.Type: GrantFiled: July 23, 2004Date of Patent: July 10, 2007Assignee: Atopic Pty. Ltd.Inventor: Thomas J. Borody
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Patent number: 7232845Abstract: The invention relates to novel active compound combinations of certain cyclic ketoenols and certain insecticidally active compounds that together have very good insecticidal and acaricidal properties.Type: GrantFiled: February 8, 2006Date of Patent: June 19, 2007Assignee: Bayer CropScience AGInventors: Reiner Fischer, Thomas Bretschneider, Christoph Erdelen
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Patent number: 7211694Abstract: Substituted 4-aminocyclohexanols, processes for their preparation, pharmaceutical compositions comprising these compounds and to the use of substituted 4-aminocyclohexanols in the preparation of pharmaceutical compositions for the treatment of various indications, especially pain as well as the treatment of these indications.Type: GrantFiled: September 23, 2004Date of Patent: May 1, 2007Assignee: Gruenenthal GmbHInventors: Bernd Sundermann, Hagen-Heinrich Hennies, Werner Englberger, Babette-Yvonne Koegel
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Patent number: 7208612Abstract: A crystal comprising LuxP is obtained, and a binding site for autoinducer-2 (AI-2) identified. The X-ray crystallographic data for LuxP and a LuxP-AI-2 complex is determined and used in a drug discovery method. Pharmaceutical compositions comprising ligands identified by such drug discovery methods are used to treat bacterial infections.Type: GrantFiled: August 22, 2002Date of Patent: April 24, 2007Assignee: Princeton UniversityInventors: Bonnie L. Bassler, Stephan Schauder, Xin Chen, Frederick M. Hughson, Stephen R. Cooper
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Patent number: 7205417Abstract: Compounds of the formula (I): (wherein A is an optionally substituted straight-chain hydrocarbon having 1 to 6 carbon atoms, which is optionally intervened by oxygen or nitrogen atom; Ar1 is aryl or heteroaryl, any of which is optionally substituted; n is 0 or 1; R0 is hydrogen, or lower alkylene attached to an arbitrary, bondable position of A; T, U, V and W are independently nitrogen atom or optionally substituted methine, and at least two of T, U, V and W are said methine group; X is —N(SO2R1)—, —N(COR2)— or —CO—; Y is —C(R3)(R4)—, —O— or —N(R5)—; Z is methine or nitrogen atom) exhibit NPY antagonistic activities and are useful as agents for the treatment of various diseases related to NPY, for example, cardiovascular disorders such as hypertension, nephropathy, heart disease, vasospasm, arteriosclerosis, etc., central nervous system disorders such as bulimia, depression, anxiety, seizure, epilepsy, dementia, pain, alcoholism, drug withdrawal, circadian rhythm disorders, schizophrenia, etc.Type: GrantFiled: August 2, 2002Date of Patent: April 17, 2007Assignee: Banyu Pharmaceutical Co., Ltd.Inventors: Takehiro Fukami, Katsumasa Nonoshita, Takeshi Sagara, Hiroyuki Kishino
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Patent number: 7205289Abstract: The invention relates to novel active compound combinations of certain cyclic ketoenols and certain insecticidally active compounds that together have very good insecticidal and acaricidal properties.Type: GrantFiled: January 27, 2004Date of Patent: April 17, 2007Assignee: Bayer AktiengesellschaftInventors: Reiner Fischer, Christoph Erdelen, Thomas Bretschneider
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Patent number: 7183436Abstract: Substituted 4-aminocyclohexanols, methods of producing the same, pharmaceuticals containing these compounds, the use of substituted 4-aminocyclohexanols for producing pharmaceutical compositions for the treatment of various indications, in particular pain, and for related treatment methods.Type: GrantFiled: January 16, 2004Date of Patent: February 27, 2007Assignee: Gruenenthal GmbHInventors: Bernd Sundermann, Hagen-Heinrich Hennies, Werner Englberger, Stephan Wnendt
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Patent number: 7169940Abstract: NST 400 compounds consisting of a unit for partial coordination of Ca2+ ions (CPCU). The NST 400 compounds are optionally conjugated to another pharmaceutically active compound. The compounds and conjugates can be used for affinity filters and for binding negative charged phospholipids. The compounds and conjugates can also be used for treating diseases involving changes of cell membrane asymmetry.Type: GrantFiled: October 31, 2000Date of Patent: January 30, 2007Assignee: NST Neurosurvival Technologies Ltd.Inventor: Ilan Ziv
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Patent number: 7163957Abstract: The invention provides compounds of the formula: wherein (a) is a single or double bond; W is CH, CH2, CHCH3, CCH3, C(CH3)2, C(CH2)2 or C(CH2)3, provided that when (a) is a double bond, then W is CH or CCH3, and when (a) is a single bond, then W is CH2, CHCH3, C(CH3)2, C(CH2)2 or C(CH2)3; X is CH or N; and Y is H or F, and salts, hydrates, tautomers, pure enantiomers, and enantiomeric mixtures; and a method of treating schizophrenia comprising administering same.Type: GrantFiled: October 16, 2003Date of Patent: January 16, 2007Assignee: Pierre Fabre MedicamentInventors: Bernard Vacher, Stéphane Cuisiat, Wouter Koek, Francis Colpaert
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Patent number: 7141603Abstract: The present invention provides compounds of general formula I or II: wherein R1, R2, R3, R4, R5, R6, and R7 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions comprising compounds of formula I or II, intermediates and processes useful for preparing compounds of formula I or II, and methods comprising inhibiting tumor growth or treating cancer by administering one or more compounds of formula I or II.Type: GrantFiled: June 13, 2005Date of Patent: November 28, 2006Assignee: The Regents of The University CaliforniaInventors: Trevor C. McMorris, Michael J. Kelner
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Patent number: 7098225Abstract: The invention relates to novel active compound combinations of certain cyclic ketoenols and certain active compounds that together have unexpectedly good insecticidal and acaricidal properties.Type: GrantFiled: May 10, 2004Date of Patent: August 29, 2006Assignee: Bayer AktiengesellschaftInventors: Reiner Fischer, Christoph Erdelen, Thomas Bretschneider
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Patent number: 6992093Abstract: Methods of inhibiting lipofibroblast to myofibroblast transdifferentiation in a mammal are disclosed comprising administering a PPAR gamma ligand when said mammal is exposed to a hyperoxic condition.Type: GrantFiled: January 27, 2003Date of Patent: January 31, 2006Assignee: Los Angeles Biomedical Research Institute at Harbor UCLA Medical CenterInventors: John S. Torday, Virender K. Rehan
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Patent number: 6977270Abstract: A description is given of the use of at least one compound of the formula I where R1, R2, R3 and R4 independently of one another are H or C1-C6-alkyl; and the use of a compound of the formula I for medical use.Type: GrantFiled: July 13, 2001Date of Patent: December 20, 2005Assignee: BASF AktiengesellschaftInventors: Kai-Uwe Baldenius, Hartwig Schröder, Klaus Krämer, Karin Schein, Rainer Stürmer
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Patent number: 6962894Abstract: A selectively herbicidal composition for controlling grasses and weeds in crops of useful plants, comprising a) a herbicidally effective amount of a compound of formula I or a salt or diastereoisomer of a compound of formula I, and b) an amount, which is effective for antagonism of the herbicide, of a compound of formula IIaType: GrantFiled: September 5, 2000Date of Patent: November 8, 2005Assignee: Syngenta Crop Protection, Inc.Inventor: Jutta Glock
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Patent number: 6962938Abstract: The present application describes novel spiro-cyclic ?-amino acid derivatives of formula I: or pharmaceutically acceptable salt forms thereof, wherein ring B is a 3-13 membered carbocycle or heterocycle, ring C forms a 3-11 membered spiro-carbocycle or spiro-heterocycleon ring B, and the other variables are defined in the present specification, which are useful as as matrix metalloproteinases (MMP), TNF-? converting enzyme (TACE), and/or aggrecanase inhibitors.Type: GrantFiled: December 18, 2003Date of Patent: November 8, 2005Assignee: Bristol-Myers Squibb Pharma CompanyInventors: Gregory R. Ott, Xiao Tao Chen, Jingwu Duan, Matthew E. Voss
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Patent number: 6933261Abstract: The invention relates to new phenyl-substituted cyclic ketoenols of the formula (I) in which Het represents one of the groups wherein A, B, D, G, X, Y and Z have the meaning given in the description, several processes and intermediate products for their preparation and their use as pest control agents and herbicides.Type: GrantFiled: September 19, 2002Date of Patent: August 23, 2005Assignee: Bayer AktiengesellschaftInventors: Folker Lieb, Hermann Hagemann, Arno Widdig, Michael Ruther, Reiner Fischer, Thomas Bretschneider, Christoph Erdelen, Ulrike Wachendorff-Neumann, Hans-Joachim Santel, Markus Dollinger, Alan Graff, Norbert Mencke, Andreas Turberg, Peter Dahmen
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Patent number: 6919090Abstract: The invention relates to novel active combinations of certain cyclic ketoenols and certain active compounds that together have unexpectedly good insecticidal and acaricidal properties.Type: GrantFiled: April 2, 2001Date of Patent: July 19, 2005Assignee: Bayer AktiengesellschaftInventors: Reiner Fischer, Christoph Erdelen, Thomas Bretschneider
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Patent number: 6908918Abstract: The present invention provides compounds of general formula I or II: wherein R1, R2, R3, R4, R5, R6, and R7 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions comprising compounds of formula I or II, intermediates and processes useful for preparing compounds of formula I or II, and methods comprising inhibiting tumor growth or treating cancer by administering one or more compounds of formula I or II.Type: GrantFiled: April 14, 2003Date of Patent: June 21, 2005Assignee: Regents of the University of CaliforniaInventors: Trevor C. McMorris, Michael J. Kelner
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Patent number: 6906205Abstract: A means and method for treating malaria, schistosomiasis, and cancer using a spiro or dispiro 1,2,4-trioxolane is described. The preferred 1,2,4-trioxolanes include a spiroadamantane group on one side of the trioxolane group, and a spirocyclohexyl on the other side of the trioxolane group, whereby the spirocyclohexyl ring is preferably substituted at the 4-position. In comparison to artemisinin semisynthetic derivatives, the compounds of this invention are structurally simple, easy to synthesize, non-toxic, and potent against malarial parasites.Type: GrantFiled: December 19, 2003Date of Patent: June 14, 2005Assignee: Medicines for Malaria Venture MMVInventors: Jonathan L. Vennerstrom, Yuxiang Dong, Jacques Chollet, Hugues Matile, Maniyan Padmanilayam, Yuangqing Tang, William N. Charman
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Patent number: 6900190Abstract: The invention relates to novel active compound combinations of certain cyclic ketoenols and certain active compounds that together have unexpectedly good insecticidal and acaricidal properties.Type: GrantFiled: March 15, 2001Date of Patent: May 31, 2005Assignee: Bayer AktiengesellschaftInventors: Reiner Fischer, Christoph Erdelen, Thomas Bretschneider
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Patent number: 6894074Abstract: The invention relates to insecticidal mixtures comprising compounds of the formula (I) in which X?, Y?, Z?, n, G?, A? and B? are as defined above and agonists and/or antagonists of nicotinic acetylcholine receptors, for protecting plants against attack by pests.Type: GrantFiled: September 29, 2003Date of Patent: May 17, 2005Assignee: Bayer AktiengesellschaftInventors: Thomas Bretschneider, Reiner Fischer, Christoph Erdelen, Ernst Brück
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Patent number: 6893651Abstract: The invention relates to insecticidal and acaricidal mixtures comprising certain cyclic ketoenols and agonists or antagonists of nicotinic acetylcholine receptors for protecting plants against attack by pests.Type: GrantFiled: September 25, 2000Date of Patent: May 17, 2005Assignee: Bayer AktiengesellschaftInventors: Reiner Fischer, Christoph Erdelen
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Patent number: 6863902Abstract: The invention relates to oral pharmaceutical compositions useful as aldosterone receptor blockers comprising the active agent micronized eplerenone in an amount of about 10 mg to about 1000 mg and one or more carrier materials.Type: GrantFiled: November 6, 2002Date of Patent: March 8, 2005Assignee: G. D. Searle & Co.Inventors: Shilpa S. Thosar, Rajeev D. Gokhale, Dwain S. Tolbert
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Patent number: 6861391Abstract: Trifluoromethyl-substituted spirocyclic ketoenols of the formula (I) are provided wherein Het represents one of the groups and G, V, W, X, Y, and Z are as defined in the specification. Also provides are processes for the preparation of the compounds. The compounds of formula (I) find use as pesticides.Type: GrantFiled: September 19, 2000Date of Patent: March 1, 2005Assignee: Bayer AktiengesellschaftInventors: Reiner Fischer, Alan Graff, Thomas Bretschneider, Christoph Erdelen, Mark Wilhelm Drewes, Dieter Feucht
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Patent number: 6846837Abstract: Methods and topical pharmaceutical formulations are provided for the treatment of nail fungus (onychomycosis). The invention involves a pharmacologically active antifungal agent, plus a pharmaceutically acceptable base in a formulation having a pH of 7.5 to about 13.0, preferably about 8.0 to 11.5, and most preferably about 8.5 to 10.5. These basic formulations permeate the nail and are effective in treating fungal infections of the nail and surrounding tissues.Type: GrantFiled: June 21, 2002Date of Patent: January 25, 2005Inventors: Howard I. Maibach, Eric C. Luo, Tsung-Min Hsu