With An Additional Active Ingredient Patents (Class 514/479)
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Patent number: 5938825Abstract: This invention is directed to stabilized antimicrobial compositions which have been stabilized using mixture of at least one halopropynyl compound, and particularly a halopropynyl carbamate fungicide such as IPBC and an effective UV absorber.Type: GrantFiled: May 21, 1998Date of Patent: August 17, 1999Assignee: Troy Technology Corporation Inc.Inventors: Kamlesh D. Gaglani, Meihua Yang
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Patent number: 5932609Abstract: This invention is a pharmaceutical composition that inhibits the growth of cancers and tumors in mammals, particularly in human and warm blooded animals. The composition contains N-chlorophenylcarbamates and N-chlorophenylthiocarbamates along with a chemotherapeutic agent and optionally a potentiator. A composition for treating viral infections in animals or humans comprising a safe and effective amount of N-chlorophenylcarbamates and the N-chlorophenylthiocarbamates and a potentiator is also disclosed.Type: GrantFiled: June 16, 1997Date of Patent: August 3, 1999Assignee: The Procter & Gamble CompanyInventor: James Berger Camden
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Patent number: 5922761Abstract: In accordance with the present invention, there are provided methods for the in vivo reduction of free iron ion levels in a mammalian subject. The present invention employs a scavenging approach whereby free iron ions are bound in vivo to a suitable physiologically compatible scavenger. The resulting complex renders the free iron ions harmless, and is eventually excreted in the urine of the host. Further in accordance with the present invention, there are provided compositions and formulations useful for carrying out the above-described methods. An exemplary scavenger contemplated for use in the practice of the present invention is a dithiocarbamate-containing composition. This material binds to free iron ions, forming a stable, water-soluble dithiocarbamate-iron complex.Type: GrantFiled: September 6, 1996Date of Patent: July 13, 1999Assignee: Medinox, Inc.Inventor: Ching-San Lai
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Patent number: 5916930Abstract: This invention is directed towards stabilizing the biocidal activity of an alkyd composition containing a halopropargyl compound and a transition metal drier by use of a chelating agent.Type: GrantFiled: November 20, 1996Date of Patent: June 29, 1999Assignee: Troy CorporationInventors: Kamiesh Gaglani, Meihua Yang, Bernard Magier
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Patent number: 5886031Abstract: Disclosed herein is hair-care cosmetic compositions comprising iodopropynyl butylcarbamate and/or a solution of zinc pyrithione in N-acyl ethylenediamine triacetate.Type: GrantFiled: May 22, 1997Date of Patent: March 23, 1999Assignee: Pacific CorporationInventors: Moon Sam Shin, Sang Cho Choi, Yong Duk Kwak, Seong Hwan Seo, Han Il Jeong, Kyung Hee Seo
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Patent number: 5877220Abstract: The present invention provides amide-based oligomeric cationic lipids. The present invention further provides compositions of these amide-based cationic lipids with anionic macromolecules, methods for interfering with protein expression in a cell utilizing these compositions and a kit for preparing the same.Type: GrantFiled: March 6, 1997Date of Patent: March 2, 1999Assignee: Genta, IncorporatedInventors: David Aaron Schwartz, Brian Patrick Dwyer, William J. Daily, Kumar Srinivasan, Bob Dale Brown
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Patent number: 5866514Abstract: A pesticidal composition to noxious organisms which comprises a diarylalkane and an active component effective for killing or repelling noxious organisms and the diarylalkane is at least one member selected from the group consisting of butyl diphenylmethane, butyl-1,1-diphenylethane and butyl-1,2-diphenylethane. The used diarylalkane has a high dissolving power to the effective component, a high boiling point and a high flash point with low unpleasant smell and does not deteriorate the effective component in the pesticidal composition.Type: GrantFiled: July 10, 1996Date of Patent: February 2, 1999Assignee: Nippon Petrochemicals Company, LimitedInventors: Kunio Sugisawa, Yasuo Togami, Toshikatsu Shouko
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Patent number: 5855654Abstract: Disclosed is a method of inhibiting the growth of marine organisms on a marine structure, by applying dihydropyridazinone and pyridazinone compounds onto or into the marine structure. These compounds may be directly incorporated into the marine structure during manufacture, directly applied to the structure, or applied to the structure by means of a coating.Type: GrantFiled: December 9, 1997Date of Patent: January 5, 1999Assignee: Rohm and Haas CompanyInventors: Gary Lewis Willingham, Samuel Eugene Sherba, Barry Clifford Lange, Enrique Luis Michelotti
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Patent number: 5853463Abstract: Disclosed is a method of inhibiting the growth of marine organisms on a marine structure, by applying diphenyldiones. These compounds may be directly incorporated into the marine structure during manufacture, directly applied to the structure, or applied to the structure by means of a coating.Type: GrantFiled: July 1, 1998Date of Patent: December 29, 1998Assignee: Rohm and Haas CompanyInventors: Gary Lewis Willingham, Linda Marguerite Oltman
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Patent number: 5849958Abstract: Pesticidal 1,4-diaryl-2-fluoro-2-butene compounds having the structural formula I ##STR1## and compositions and methods comprising those compounds for the control of insect and acarid pests.Type: GrantFiled: March 17, 1997Date of Patent: December 15, 1998Assignee: American Cyanamid CompanyInventors: Keith D. Barnes, Yulin Hu
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Patent number: 5846959Abstract: A method for the treatment of cardiovascular diseases and noncardiovascular inflammatory diseases that are mediated by VCAM-1 is provided that includes the removal, decrease in the concentration of, or prevention of the formation of oxidized polyunsaturated fatty acids, or interferes with a complex formed between a polyunsaturated fatty acid or an oxidized polyunsaturated fatty acid and a protein or peptide that mediates the expression of VCAM-1. A method is also provided for suppressing the expression of a redox-sensitive gene or activating a gene that is suppressed through a redox-sensitive pathway, that includes administering an effective amount of a substance that prevents the oxidation of the oxidized signal, and typically, the oxidation of a polyunsaturated fatty acid, or interferes with a complex formed between the oxidized signal and a protein or peptide that mediates the expression of the redox gene.Type: GrantFiled: June 6, 1995Date of Patent: December 8, 1998Assignee: Emory UniversityInventors: Russell M. Medford, R. Wayne Alexander, Sampath Parthasarathy, Bobby V. Khan
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Patent number: 5843974Abstract: A method of inhibiting melanoma comprising administering to a human in need thereof an effective amount of a compound having the formula ##STR1## wherein R.sup.1 and R.sup.3 are independently hydrogen, ##STR2## wherein Ar is optionally substituted phenyl; R.sup.2 is selected from the group consisting of pyrrolidine, hexamethyleneamino, and piperidino, or a pharmaceutically acceptable salt of solvate thereof; alone or in combination with one or more melanoma-inhibiting agents.Type: GrantFiled: June 6, 1995Date of Patent: December 1, 1998Assignee: Eli Lilly and CompanyInventor: Robert A. Swift
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Patent number: 5833742Abstract: Disclosed is a method of inhibiting the growth of marine organisms on a marine structure, by applying onto or into the marine structure a phenylamide compound. These compounds may be directly incorporated into the marine structure during manufacture, directly applied to the structure, or applied to the structure by means of a coating.Type: GrantFiled: October 9, 1997Date of Patent: November 10, 1998Assignee: Rohm and Haas CompanyInventors: Gary Lewis Willingham, Samuel Eugene Sherba, Barry Clifford Lange
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Patent number: 5821260Abstract: Dithiocarboxylates, and in particular, dithiocarbamates, block the induced expression of the endothelial cell surface adhesion molecule VCAM-1, and are therefor useful in the treatment of cardiovascular disease, including atherosclerosis, post-angioplasty restenosis, coronary artery diseases, and angina, as well as noncardiovascular inflammatory diseases that are mediated by VCAM-1.Type: GrantFiled: June 7, 1995Date of Patent: October 13, 1998Assignee: Emory UniversityInventors: Russell M. Medford, Margaret K. Offermann, R. Wayne Alexander, Sampath Parthasarathy
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Patent number: 5814659Abstract: The present invention comprises a topical analgesic composition comprising an analgesic agent, an alcohol, a chaotropic agent and an unsaturated fatty acid. The composition is preferably in the form of a stable gel and may further comprise a pharmaceutically acceptable emulsifier, a pharmaceutically acceptable gelling and/or thickening agent, and a pharmaceutically acceptable preservative. The pH of the composition is adjusted to 7.5-8.0 by the addition of a pharmaceutically acceptable organic base, such as triethanolamine.The invention also comprises a method for inducing topical analgesia. The composition is absorbed on an absorbent material, for example a cotton strip inserted into typical skin-wipe packet; brought in contact with the skin of a person in need of such an analgesia; and maintained in contact with the skin for a period of time sufficient to induce and maintain topical analgesia.Type: GrantFiled: April 23, 1996Date of Patent: September 29, 1998Assignee: DTR Dermal Therapy (Barbados) Inc.Inventor: Harry Richardson Elden
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Patent number: 5807891Abstract: Antiretroviral compounds (which are effective, for example, against HIV) of the formula I ##STR1## in which R.sub.Type: GrantFiled: April 8, 1997Date of Patent: September 15, 1998Assignee: Novartis AGInventors: Guido Bold, Hans-Georg Capraro, Alexander Fassler, Marc Lang, Shripad Subray Bhagwat, Satish Chandra Khanna, Janis Karlis Lazdins, Jurgen Mestan
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Patent number: 5807957Abstract: A mixture of lipophilic and amphiphilic/hydrophilic film-forming polymers of the formula (I)R--(CO).sub.m Y.sup.1 --(CH.sub.2 CHR.sup.1 O).sub.n --?CONH--Z--NHCO(OCH.sub.2 CHR.sup.2).sub.n' --Y.sup.2 --(CH.sub.2 CHR.sup.2 O).sub.n" !.sub.p --CONH--Z--NHCO--(OCH.sub.2 CHR.sup.1).sub.n --Y.sup.1 (CO).sub.m R (I)where R represents (i) an alkyl, alkenyl or alkaryl group of from 1 to 30 carbon atoms or (ii) a polypropylene oxide group or polybutylene oxide group; R.sup.1 and R.sup.2, each, independently, represent a hydrogen atom, or a methyl or ethyl group; Z represents a divalent linking hydrocarbyl group; m is 0 or 1; when m=0, Y.sup.1 represents O, NR.sup.3 or N.sup.+ R.sup.3 R.sup.4 X.sup.- and when m=1 Y.sup.1 represents O; Y.sup.2 represents O, NR.sup.3, N.sup.+ R.sup.3 R.sup.4 X.sup.-, (R.sup.3 NCH.sub.2 CH.sub.2).sub.t, or ?(R.sup.3 R.sup.4 N.sup.+ CH.sub.2 CH.sub.2)X.sup.- !.sub.t ; R.sup.3 and R.sup.4, independently, represent C.sub.1 -C.sub.Type: GrantFiled: December 23, 1996Date of Patent: September 15, 1998Assignee: MacroChem CorporationInventors: Carlos M. Samour, Scott F. Krauser
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Patent number: 5807884Abstract: A method for the treatment of cardiovascular diseases and noncardiovascular inflammatory diseases that are mediated by VCAM-1 is provided that includes the removal, decrease in the concentration of, or prevention of the formation of oxidized polyunsaturated fatty acids, or interferes with a complex formed between a polyunsaturated fatty acid or an oxidized polyunsaturated fatty acid and a protein or peptide that mediates the expression of VCAM-1. A method is also provided for suppressing the expression of a redox-sensitive gene or activating a gene that is suppressed through a redox-sensitive pathway, that includes administering an effective amount of a substance that prevents the oxidation of the oxidized signal, and typically, the oxidation of a polyunsaturated fatty acid, or interferes with a complex formed between the oxidized signal and a protein or peptide that mediates the expression of the redox gene.Type: GrantFiled: October 4, 1994Date of Patent: September 15, 1998Assignee: Emory UniversityInventors: Russell M. Medford, R. Wayne Alexander, Sampath Parthasarathy, Bobby V. Khan
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Patent number: 5792787Abstract: Dithiocarboxylates, and in particular, dithiocarbamates, block the induced expression of the endothelial cell surface adhesion molecule VCAM-1, and are therefor useful in the treatment of cardiovascular disease, including atherosclerosis, post-angioplasty restenosis, coronary artery diseases, and angina, as well as noncardiovascular inflammatory diseases that are mediated by VCAM-1.Type: GrantFiled: June 7, 1995Date of Patent: August 11, 1998Assignee: Emory UniversityInventors: Russell M. Medford, R. Wayne Alexander, Margaret K. Offermann
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Patent number: 5783596Abstract: Dithiocarboxylates, and in particular, dithiocarbamates, block the induced expression of the endothelial cell surface adhesion molecule VCAM-1, and are therefor useful in the treatment of cardiovascular disease, including atherosclerosis, post-angioplasty restenosis, coronary artery diseases, and angina, as well as noncardiovascular inflammatory diseases that are mediated by VCAM-1.Type: GrantFiled: June 7, 1995Date of Patent: July 21, 1998Assignee: Emory UniversityInventors: Russell M. Medford, Margaret K. Offermann, R. Wayne Alexander, Sampath Parthasarathy
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Patent number: 5776976Abstract: New active compound combinations of valinamide derivatives of the formula (I) ##STR1## in which R.sup.1 and R.sup.2 has the meaning given in the description, with known fungicidal active substances, and their use for combating phytopathogenic fungi are described.Type: GrantFiled: February 19, 1997Date of Patent: July 7, 1998Assignee: Bayer AktiengesellschaftInventors: Heinz-Wilhelm Dehne, Wilhelm Brandes, Karl-Heinz Kuck, Thomas Seitz
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Patent number: 5773231Abstract: A method for the treatment of cardiovascular diseases and noncardiovascular inflammatory diseases that are mediated by VCAM-1 is provided that includes the removal, decrease in the concentration of, or prevention of the formation of oxidized polyunsaturated fatty acids, or interferes with a complex formed between a polyunsaturated fatty acid or an oxidized polyunsaturated fatty acid and a protein or peptide that mediates the expression of VCAM-1. A method is also provided for suppressing the expression of a redox-sensitive gene or activating a gene that is suppressed through a redox-sensitive pathway, that includes administering an effective amount of a substance that prevents the oxidation of the oxidized signal, and typically, the oxidation of a polyunsaturated fatty acid, or interferes with a complex formed between the oxidized signal and a protein or peptide that mediates the expression of the redox gene.Type: GrantFiled: June 7, 1995Date of Patent: June 30, 1998Assignee: Emory UniversityInventors: Russell M. Medford, R. Wayne Alexander, Sampath Parthasarathy, Bobby V. Khan
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Patent number: 5773209Abstract: A method for the treatment of cardiovascular diseases and noncardiovascular inflammatory diseases that are mediated by VCAM-1 is provided that includes the removal, decrease in the concentration of, or prevention of the formation of oxidized polyunsaturated fatty acids, or interferes with a complex formed between a polyunsaturated fatty acid or an oxidized polyunsaturated fatty acid and a protein or peptide that mediates the expression of VCAM-1. A method is also provided for suppressing the expression of a redox-sensitive gene or activating a gene that is suppressed through a redox-sensitive pathway, that includes administering an effective amount of a substance that prevents the oxidation of the oxidized signal, and typically, the oxidation of a polyunsaturated fatty acid, or interferes with a complex formed between the oxidized signal and a protein or peptide that mediates the expression of the redox gene.Type: GrantFiled: June 7, 1995Date of Patent: June 30, 1998Assignee: Emory UniversityInventors: Russell M. Medford, R. Wayne Alexander, Sampath Parthasarathy, Bobby V. Khan
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Patent number: 5750351Abstract: A method for the treatment of cardiovascular diseases and noncardiovascular inflammatory diseases that are mediated by VCAM-1 is provided that includes the removal, decrease in the concentration of, or prevention of the formation of oxidized polyunsaturated fatty acids, or interferes with a complex formed between a polyunsaturated fatty acid or an oxidized polyunsaturated fatty acid and a protein or peptide that mediates the expression of VCAM-1. A method is also provided for suppressing the expression of a redox-sensitive gene or activating a gene that is suppressed through a redox-sensitive pathway, that includes administering an effective amount of a substance that prevents the oxidation of the oxidized signal, and typically, the oxidation of a polyunsaturated fatty acid, or interferes with a complex formed between the oxidized signal and a protein or peptide that mediates the expression of the redox gene.Type: GrantFiled: June 7, 1995Date of Patent: May 12, 1998Assignee: Emory UniversityInventors: Russell M. Medford, R. Wayne Alexander, Sampath Parthasarathy, Bobby V. Khan
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Patent number: 5733362Abstract: This invention is directed to a bactericidal composition which comprises a synergistic mixture of 2-methyl-4,5-trimethylene-4-isothiazoline-3-on; 3-iodo-2-propynyl butyl carbamate and 2-phenoxyethanol.Type: GrantFiled: December 2, 1996Date of Patent: March 31, 1998Assignee: Troy CorporationInventor: Lothar Hahn
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Patent number: 5733935Abstract: A hydroxylamine derivatives of formula (I): ##STR1## wherein R represents ##STR2## in which R.sup.1 and R.sup.2 represents alkyl group, alkenyl group, alkynyl group, cycloalkyl group, haloalkyl group, haloalkynyl group, alkoxy - alkyl group, phenoxy - alkyl group, alkylthio - alkyl group, alkylsulfonyl - alkyl group, alkylamino - alkyl group, phenyl group, benzyl group, phenethyl group, cinnamyl group, pyridyl group, furyl group, thienyl group, X represents CO.sub.2, CO or SO.sub.2, and R.sup.3, R.sup.4, R.sup.5 and R.sup.6 represent a hydrogen atom or a lower alkyl group, and n represents 0 or 1, and fungicides contain said compound as an active ingredient.The compounds of the present invention have excellent effects for controlling wood-rot fungi, plant diseases and fungi of humans and animals, and are useful as industrial, agricultural and medical fungicides.Type: GrantFiled: June 17, 1996Date of Patent: March 31, 1998Assignee: Nihon Nohyaku Co., Ltd.Inventors: Nobuharu Andoh, Tsutomu Nishiguchi, Katsutoshi Endo
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Patent number: 5709890Abstract: An insecticide composition is enhanced from the standpoint of its ability to be absorbed by insects, such as red fire ants, particularly dithiophosphate ester pesticides by the addition of a small amount of a water soluble non-aromatic polyorganic acid or salt form thereof such as polyaspartic acid, particularly preferred with a molecular weight in the range of about 3000 to 40,000.Type: GrantFiled: March 20, 1997Date of Patent: January 20, 1998Assignee: Donlar CorporationInventor: J. Larry Sanders
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Patent number: 5707929Abstract: This invention is directed to a broad spectrum fungicide/algaecide composition which comprises a mixture of (a) at least one halopropynyl compound and (b) at least one sulfur-containing s-triazine, said mixture provided in an amount to prevent and/or protect a substrate from attack by one or more fungal and/or algael organisms. The composition can be used broadly in industrial systems and more particularly with substrates such as paints, coatings, stucco, concrete, stone, cementaceous surfaces, wood, caulking, sealants, textiles, and the like.Type: GrantFiled: May 8, 1995Date of Patent: January 13, 1998Assignee: Troy Chemical CorporationInventors: Eeva-Liisa Kuusisto, Kurt Laurits Hansen
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Patent number: 5663200Abstract: Antiretroviral compounds (which are effective, for example, against HIV) of the formula I ##STR1## in which R.sub.Type: GrantFiled: October 19, 1995Date of Patent: September 2, 1997Assignee: Ciba-Geigy CorporationInventors: Guido Bold, Hans-Georg Capraro, Alexander Fassler, Marc Lang, Shripad Subray Bhagwat, Satish Chandra Khanna, Janis Karlis Lazdins, Jurgen Mestan
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Patent number: 5650423Abstract: New active compound combinations of valinamide derivatives of the formula (I) ##STR1## in which R.sup.1 and R.sup.2 has the meaning given in the description,with known fungicidal active substances, and their use for combating phytopathogenic fungi are described.Type: GrantFiled: November 6, 1995Date of Patent: July 22, 1997Assignee: Bayer AktiengesellschaftInventors: Heinz-Wilhelm Dehne, Wilhelm Brandes, Karl-Heinz Kuck, Thomas Seitz
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Patent number: 5646133Abstract: An insecticide composition is enhanced from the standpoint of its ability to be absorbed by insects, such as red fire ants, particularly dithiophosphate ester pesticides by the addition of a small amount of a water soluble non-aromatic polyorganic acid or salt form thereof such as polyaspartic acid, particularly preferred with a molecular weight in the range of about 3000 to 40,000.Type: GrantFiled: March 14, 1996Date of Patent: July 8, 1997Assignee: Donlar CorporationInventor: J. Larry Sanders
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Patent number: 5631273Abstract: A water soluble preservative antimicrobial composition for addition to commercial use products at predetermined use levels to provide synergistic biocidal activity against a wide range of fungi and gram-negative and gram-positive bacteria, comprising an active liquid blend of(1) an admixture of(a) one or more methylol compounds selected from the group consisting of N-[1,3-bis (hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]-N,N'-bis (hydroxymethyl) urea; 1,3-dimethylol-5,5-dimethyl hydantoin; sodium hydroxymethyl glycinate; 1,1-methylene bis[3-[3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]urea]; and glycine anhydride dimethylol; and(b) 3-iodo-2-propynylbutyl carbamate, in a weight ratio of (a):(b) of 100:1 to 2000:1, and(2) propylene glycol or 1,3-butylene glycol.Type: GrantFiled: May 23, 1996Date of Patent: May 20, 1997Assignee: ISP Chemicals Inc.Inventor: John J. Merianos
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Patent number: 5612372Abstract: Dispersant pesticide compositions which comprise a pesticide and a salt or partial salt of an alkyl substituted amine and a phosphonic acid.Type: GrantFiled: September 4, 1990Date of Patent: March 18, 1997Assignee: IBC Manufacturing CompanyInventor: Michael H. West
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Patent number: 5599836Abstract: A pharmaceutical product is disclosed which interferes with pathologies of human sensitivity and of the motor system. This product comprises parasympathomimetic drugs, in particular carbachol, methacholine or bethanechol and it has a broad application in the medical and neurological clinical fields.Type: GrantFiled: September 16, 1994Date of Patent: February 4, 1997Inventor: Maurizio Santini
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Patent number: 5552425Abstract: A water soluble preservative antimicrobial composition for addition to commercial use products at predetermined use levels to provide synergistic biocidal activity against a wide range of fungi and gram-negative and gram-positive bacteria, comprising an active liquid blend of(1) an admixture of(a) one or more methylol compounds selected from the group consisting of N-[1,3-bis (hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]-N,N'-bis (hydroxymethyl) urea; 1,3-dimethylol-5,5-dimethyl hydantoin; sodium hydroxymethyl glycinate; 1,1-methylene bis[3-[3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]urea]; and glycine anhydride dimethylol; and(b) 3-iodo-2-propynylbutyl carbamate, in a weight ratio of (a):(b) of 100:1 to 2000:1, and(2) propylene glycol or 1,3-butylene glycol.Type: GrantFiled: March 30, 1995Date of Patent: September 3, 1996Assignee: ISP Chemicals Inc.Inventor: John J. Merianos
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Patent number: 5496842Abstract: A water soluble preservative admixture of biocidal compounds for addition to commercial use compositions at predetermined use levels, and uniformly distributed therein, to provide long-time synergistic biocidal activity against a wide range of fungi and both gram-negative and gram-positive bacteria, which comprises powders of(a) one or more methylol compounds, or their equivalents, and(b) iodopropynyl alcohol, or its ester, carbamate or ether derivative thereof, in a weight ratio of (a):(b) of 100:1 to 2000:1.Type: GrantFiled: February 22, 1995Date of Patent: March 5, 1996Assignee: ISP Chemicals Inc.Inventor: John J. Merianos
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Patent number: 5491165Abstract: New active compound combinations of valinamide derivatives of the formula (I) ##STR1## in which R.sup.1 and R.sup.2 has the meaning given in the description,with known fungicidal active substances, and their use for combating phytopathogenic fungi are described.Type: GrantFiled: February 4, 1994Date of Patent: February 13, 1996Assignee: Bayer AktiengesellschaftInventors: Heinz-Wilhelm Dehne, Wilhelm Brandes, Karl-Heinz Kuck, Thomas Seitz
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Patent number: 5482965Abstract: A method and compositions for enhancing absorption of topically administered physiologically active agents through the skin and mucous membranes of humans and animals in a transdermal device or formulation for local or systemic use, comprising a therapeutically effective amount of a pharmaceutically active agent and a non-toxic, effective amount of penetration enhancing agent of the formula I or a physiologically acceptable salt thereof: ##STR1## wherein: R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are as defined herein.Type: GrantFiled: September 3, 1993Date of Patent: January 9, 1996Inventor: Vithal J. Rajadhyaksha
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Patent number: 5470875Abstract: A water soluble, antimicrobial composition having antifungal activity useful for disinfecting a contact lens comprise (a) polyhexamethylene biguanide and (b) iodopropynylbutyl carbamate, in a weight ratio of (a):(b) of at least 100:1.Type: GrantFiled: January 6, 1995Date of Patent: November 28, 1995Assignee: ISP Chemicals Inc.Inventors: John J. Merianos, Todd Elder, Paul Garelick
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Patent number: 5428050Abstract: A water soluble preservative admixture of biocidal compounds for addition to commercial use compositions at predetermined use levels, and uniformly distributed therein, to provide long-time synergistic biocidal activity against a wide range of fungi and both gram-negative and gram-positive bacteria, which comprises powders of(a) one or more methylol compounds, or their equivalents, and(b) iodopropynyl alcohol, or its ester, carbamate or ether derivative thereof,in a weight ratio of (a):(b) of 100:1 to 2000:1.Type: GrantFiled: April 28, 1994Date of Patent: June 27, 1995Assignee: ISP Chemicals Inc.Inventor: John J. Merianos
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Patent number: 5416109Abstract: A microbial inhibiting composition and method is disclosed. The composition comprises an amount, effective for the intended purpose of 3-iodo-2-propynyl-butyl carbamate and n-alkyl dimethyl benzyl ammonium chloride. The method comprises administering an amount of this combined treatment to the particular water containing system for which treatment is desired.Type: GrantFiled: January 19, 1994Date of Patent: May 16, 1995Assignee: Betz Laboratories, Inc.Inventors: Deborah K. Donofrio, Wilson K. Whitekettle
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Patent number: 5385926Abstract: New synergistic microbicidal active compound combinations, and the use thereof, comprising an azole fungicide, such as hexaconazole, and an iodopropargyl derivative, such as IPBC, if appropriate with the addition of other active compounds.Type: GrantFiled: October 26, 1993Date of Patent: January 31, 1995Assignee: Bayer AktiengesellschaftInventors: Georg-Wilhelm Ludwig, Otto Exner, Wilfried Paulus, Karl-Heinz Buchel, Graham Holmwood
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Patent number: 5374631Abstract: Synergistic combinations of iodopropargyl compounds and hexahydro-1,3,5-tris(2-hydroxyethyl)-s-triazine for use in controlling the growth of microorganisms, such as fungi and bacteria in aqueous fluids, such as metalworking fluids.Type: GrantFiled: January 27, 1993Date of Patent: December 20, 1994Assignee: Buckman Laboratories International, Inc.Inventors: David Oppong, S. Rao Rayudu
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Patent number: 5356931Abstract: Alpha-Arylacrylic acid derivatives of the general formula I ##STR1## where X is ethylene or ethenylene; n is 0 or 1;m is 0, 1, 2, 3 or 4;R.sup.1 is cyano, cyanato, thiocyanato, nitro, hydroxyl, carboxyl, haloalkyl, haloalkoxy, unsubstituted or substituted cycloalkyl, cycloalkenyl, cycloalkadienyl, alkenyl, alkynyl or amino, alkylcarbonyl, alkoxycarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, unsubstituted or substituted benzyloxycarbonyl, benzoyl, phenylalkyl, phenylalkoxy or phenoxyalkyl,or R.sup.1 together with one of the radicals R.sup.2 forms an unsubstituted or substituted 1,3-butadiene-1,4-diyl group or an unsubstituted or substituted chain consisting of carbon members and an oxygen member, andR.sup.2 is halogen, unsubstituted or substituted alkyl, alkoxy, alkenyloxy, alkynyloxy, alkadienyloxy, benzyloxy or benzylthio, are used for controlling pests.Type: GrantFiled: January 4, 1993Date of Patent: October 18, 1994Assignee: BASF AktiengesellschaftInventors: Reinhard Kirstgen, Rainer Otter, Christoph Kuenast, Uwe Kardorff, Wolfgang Steglich, Gunda Bertram
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Patent number: 5328926Abstract: Synergistic combinations of iodopropargyl compounds and 1,2-benzisothiazolin-3-one for use in controlling the growth of at least one microorganism, such as fungi and bacteria in aqueous fluids, such as metalworking fluids.Type: GrantFiled: March 1, 1993Date of Patent: July 12, 1994Assignee: Buckman Laboratories International, Inc.Inventor: David Oppong
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Patent number: 5304567Abstract: Synergistic microbicidal compositions are disclosed, comprising 4,5-dichloro-2-cyclohexyl-3-isothiazolone and one or more known microbicides for more effective, and broader control of microorganisms in various systems.Type: GrantFiled: October 5, 1993Date of Patent: April 19, 1994Assignee: Rohm and Haas CompanyInventor: Jemin C. Hsu
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Patent number: 5300520Abstract: A wood preservative composition which comprises a wood preservative in an amount of 0.01-10% by weight and a diphenylalkane compound represented by the general formula ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are independently hydrogen or an alkyl, in an amount of not less than 1% by weight and in an amount of 1-1000 parts by weight in relation to one part by weight of the wood preservative.Type: GrantFiled: April 24, 1991Date of Patent: April 5, 1994Assignee: Takeda Chemical Industries, Ltd.Inventors: Akira Igarashi, Koh Ogura, Masayuki Asai, Kazuya Okubo, Yosei Kuwazuru
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Patent number: 5254595Abstract: Aryloxypropanolaminotetralins with beta-antagonist activity of the formula ##STR1## wherein R is hydrogen, hydroxy or methoxy and Ar is an optionally substituted aromatic or heteroaromatic group, in optically active or inactive form as well as their acid addition salts are described.A process for their preparation and pharmaceutical compositions containing the compounds of formula (i) or their pharmaceutically acceptable acid addition salts, are also described.Type: GrantFiled: January 9, 1992Date of Patent: October 19, 1993Assignee: Elf SanofiInventors: Umberto Guzzi, Marco Baroni, Sergio Boveri, Luciano Manara, Alberto Bianchetti
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Patent number: 5219875Abstract: A synergistic antimicrobial composition comprising 1,2-benzisothiazolin-3-one and iodopropargyl butylcarbamate in a ratio to each other which exhibits synergism is disclosed.Type: GrantFiled: November 27, 1990Date of Patent: June 15, 1993Assignee: Rohm and Haas CompanyInventors: Samuel E. Sherba, Raj J. Mehta, Barry C. Lange
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Patent number: 5216016Abstract: A novel synergistic insectidical composition that comprises, in addition to carriers and/or other adjuvants or diluents, a componentA consisting of an insecticidal compound of formula I ##STR1## wherein R.sub.1 is C.sub.1 -C.sub.3 alkyl, R.sub.2 is halogen and R.sub.3 is hydrogen or halogen, and also a componentB consisting of one or more insecticidal compounds selected from the group consisting of the compounds of formulae II to XV ##STR2## wherein R.sub.1 is hydrogen, methyl or ethyl and R.sub.2 is hydrogen or methyl; ##STR3## The composition is suitable especially for controlling sucking insects.Type: GrantFiled: March 6, 1992Date of Patent: June 1, 1993Assignee: Ciba-Geigy CorporationInventors: William Vorley, Friedrich Karrer, Francois Bourgeois